Dalacin C.

Munkhaniyi, mutha kuwerengera malangizo ogwiritsira ntchito mankhwalawa Dalacin. Amapereka ndemanga kuchokera kwa alendo omwe amabwera patsamba lino - ogula mankhwalawa, komanso malingaliro a akatswiri azachipatala pakugwiritsa ntchito mankhwala a Dalacin oletsa mankhwalawa machitidwe awo. Chopempha chachikulu ndikuti muwonjezere ndemanga zanu za mankhwalawa: mankhwalawo adathandizira kapena sanathandizire kuchotsa matendawa, ndizovuta ziti zomwe zimawoneka ndi zotsatirapo zake, zomwe mwina sizinalengezedwe ndi wopanga. Dalacin analogue pali kupezeka kwa analogue. Gwiritsani ntchito mankhwalawa ziphuphu (ziphuphu), kutentha thupi, kutupa kwamatoni komanso matenda ena akuluakulu, ana, komanso panthawi yoyembekezera komanso mkaka wa m`mawere. The zikuchokera mankhwala.

Dalacin - anti-semisynthetic antibayotiki wa gulu la linkosamide, wopangidwa kuchokera ku lincomycin pomwe gulu la 7 (R) - hydroxyl limasinthidwa ndi 7- (S) -chlor, yogwira motsutsana ndi tizilombo tating'onoting'ono ta aerobic gramu komanso mabakiteriya osiyanasiyana a anaerobic. Mabakiteriya ambiri a grob-negative aerobic, kuphatikizapo Enterobacteriaceae, amagonjetsedwa ndi clindamycin.

Lincosamides, monga macrolides (mwachitsanzo, erythromycin), amamangiriza mpaka gawo la 50S la ribosome la bakiteriya ndi kaphatikizidwe kaphatikizidwe ka mapuloteni koyambirira. Kutengera kuzindikira kwa tizilombo tating'onoting'ono komanso kuchuluka kwa mankhwalawa, clindamycin amatha kuchita bacteriostically (makamaka) kapena bactericidal (pamatayala akulu).

Ma tizilombo totsatirawa omwe ali ndi chidwi ndi clindamycin mu vitro:

1. Aerobic gram-cocci-cocci, kuphatikiza: Staphylococcus aureus, Staphylococcus epermidis (zotulutsa osati kupanga penicillinase). Zinadziwika (mu vitro) kukula msanga kwa kukana clindamycin ena staphylococcal erythromycin kugonjetsedwa tizilombo ta. Streptococcus spp. (kupatula Streptococcus faecalis), Pneumococcus spp.

2. Bacer ya Anaerobic gram-hasi, kuphatikiza: Bacteroides spp. (kuphatikiza gulu la B. fragilis, B. disiens, B. bivius ndi B. melaninogenicus), Fusobacterium spp.

3. Anaerobic gram-positive, non-spore kupanga bacilli, kuphatikiza Propionibacterium spp., Eubacterium spp., Actinomyces spp.

4. Anaerobic ndi microaerophilic gram-positive cocci, kuphatikiza Peptococcus spp., Peptostreptococcus spp., Microaerophilic Streptococcus spp., Clostridia spp: Clostridia imalephera kwambiri clindamycin kuposa anaerobes ena ambiri. Ma Clostridium perfringens amakhudzidwa kwambiri ndi clindamycin, koma mitundu ina, monga C. sporogenes ndi C. tertium, nthawi zambiri imaletsa clindamycin, kotero kuyesa kwamvekedwe kuyenera kuchitidwa.

5. Tizilombo tambiri, kuphatikizapo Chlamydia trachomatis, Toxoplasma gondii, Plasmodium falciparum ndi Pneumocystis carinii (kuphatikiza ndi primaquin), Gardnerella vaginalis, Mobiluncus mulieris, Mobiluncus pelaisii, Mycoplasma hominis.

Ma tizilombo totsatirawa nthawi zambiri amakhala osagwirizana ndi clindamycin: aerobic gram-negative bacilli Streptococcus faecalis, Nocardia spp., Neisseria meningitidis, mavuto a methicillin osagwira Staphylococcus aureus ndi mavuto a Haemophilus fuluwenza. Kutsutsa kwamtanda kumakhalapo pakati pa lincomycin ndi clindamycin.

Kupanga

Clindamycin + oyambitsa.

Pharmacokinetics

Pambuyo pakukonzekera pakamwa, mayankho a dalacin amodzi mofulumira komanso pafupifupi. Mukamamwa pakamwa, mayamwidwe a clindamycin (ochulukitsa) samatengera gawo lalikulu pakudya nthawi yomweyo, koma kumeza chakudya ndi kuchepa. Pali ubale womwe ulipo pakati pa kuchuluka kwa mankhwalawa clindamycin mu seramu ndi mlingo wa mankhwalawa. 40-90% ya mankhwala omwe amalumikizidwa amamangidwa kumapuloteni mthupi. Clindamycin simalowa mu magazi otchinga-ubongo (BBB) ​​(ngakhale ndi kutupa kwamitsempha, zilolezo zimawonjezeka pang'ono). Mwanjira yosasinthika, pafupifupi 10% ya mankhwalawa amachotsedwa m'thupi ndi impso, 3,6% - ndi ndowe. Zotsalazo zimapukusidwa ngati ma metabolites osagwira, makamaka ndi ndulu ndi ndowe. Clindamycin samachotsedwa ndi hemodialysis ndi peritoneal dialysis.

Zizindikiro

Matenda opatsirana komanso otupa omwe amayamba chifukwa cha mabakiteriya okhala ndi vuto la ana amtundu wa clindamycin kapena ma bacteria a gram-aerobic, monga Streptococcus spp., Staphylococcus spp. ndi Pneumococcus spp., komanso clindamycin yovuta ya Chlamydia trachomatis serovars:

• chapamwamba kupuma thirakiti matenda, kuphatikizapo tonillitis, pharyngitis, sinusitis,
• kutupa kwamakutu kwa pakati, malungo ofiira,
• matenda a m'munsi kupuma thirakiti, kuphatikizapo bronchitis, chibayo, mankhwala a pleura ndi mapapo,
• matenda opatsirana a pakhungu ndi minofu yofewa, kuphatikiza ziphuphu (ziphuphu), furunculosis, matenda a subcutaneous mafuta, impetigo, zilonda zam'mimba, mabala omwe ali ndi kachilomboka, njira zina zotupa pakhungu ndi minofu yofewa yomwe imayamba chifukwa cha tizilombo toyambitsa matenda omwe amatenga mankhwalawa, monga erysipelas ndi paronychia (panaritium),
• matenda opatsirana amafupa ndi mafupa, kuphatikiza osteomyelitis ndi nyamakazi ya septic,
• matenda opatsirana a gynecological, kuphatikizapo endometritis, matenda a subcutaneous mafuta, matenda a minofu ozungulira nyini, zotupa za fallopian machubu ndi thumba losunga mazira, salpingitis ndi matenda otupa a ziwalo za pelvic, kuphatikiza ndi antibacterial mankhwala omwe amagwira motsutsana ndi gram-negative aerobic pathogens (mwachitsanzo, glamicin),
• monotherapy matenda amchiberekero oyambitsidwa ndi Chlamydia trachomatis,
• matenda opatsirana a m'mimba, kuphatikizapo peritonitis ndi m'mimba, komanso mankhwala ena a antibacterial omwe amagwira mabakiteriya a grob-aerobic),
• septicemia ndi endocarditis,
• matenda amkamwa, monga periodontal abscess ndi periodontitis,
• toxoplasma encephalitis odwala AIDS (osakanikirana ndi pyrimethamine mwa odwala omwe ali ndi tsankho la muyezo),
• Pneumocystis chibayo mwa odwala AIDS (osakanikirana ndi primaquine mwa odwala osalolera kapena osagwirizana ndi chithandizo chamankhwala),
• malungo, incl. chifukwa cha plasmodium falciparum, onse mu mawonekedwe a monotherapy, komanso kuphatikiza quinine kapena chloroquine,
• kupewa endocarditis odwala ndi kuchuluka kudziwa penicillins,
• bakiteriya vaginosis.

Kutulutsa Mafomu

Makapisozi 150 mg ndi 300 mg (nthawi zina amatchedwa mapiritsi olakwika).

Suppositories ukazi 100 mg No. 3.

Gel yogwiritsira ntchito kunja 1% (Dalacin T).

Vaginal kirimu 3% (nthawi zina amatchedwa mafuta onunkhira).

Njira yothetsera mtsempha wa intravenous and intramuscular management (Dalacin Ts phosphate) (jakisoni m'mapiritsi a jakisoni).

Malangizo ogwiritsira ntchito ndi mtundu wa mankhwala

Pofuna kupewa zovuta, gwiritsani ntchito mosamalitsa monga adokotala amafunsa.

Akuluakulu: 600-1800 mg / tsiku pakamwa mu 2, 3 kapena 4 Mlingo wofanana.

Ana: 8-25 mg / kg thupi / tsiku pakamwa mu 3-4 Mlingo wofanana.

Pofuna kupewa kukwiya kwa esophagus, makapisozi amayenera kumwedwa ndi kapu yodzaza ndi madzi.

Ngati mlingo wowerengeka ndi mlingo umodzi wotsika kuposa zomwe zimapezeka m'mapapo kapena pali mavuto akumeza, njira zovomerezeka za makolo ziyenera kuvomerezedwa.

Matenda oyambitsidwa ndi beta-hemolytic streptococcus: Mlingo akuwonetsedwa pamwambapa, chithandizo chikuyenera kupitilizidwa kwa masiku osachepera 10.

Matenda opatsirana komanso otupa a ziwalo za m'chiberekero: 900 mg iv clindamycin maola 8 aliwonse + iv. Ma antibacterial oyenera omwe amagwira motsutsana ndi gram-negative aerobic pathogens (mwachitsanzo, ma glamicin pa mlingo wa 2.0 mg / kg wotsatiridwa ndi 1.5 mg / kg ndikutsatira 1.5 mg / kg maola asanu ndi atatu alionse kwa odwala omwe ali ndi vuto la impso), kwa masiku osachepera anayi, ndipo mkhalidwe wa wodwalayo utasintha, kwa maola osachepera 48. Kenako amayamba kutenga clindamycin mkati ndi 450-600 mg maola 6 aliwonse tsiku lililonse. Njira yonse yothandizira ndi masiku 10-14.

Chlamydia trachomatis matenda amchiberekero uster: 450-600 mg pakamwa kanayi pa tsiku kwa masiku 10-14.

Toxoplasmosis encephalitis mwa odwala a AIDS: odwala omwe ali ndi vuto loti amalephera kulandira chithandizo chokwanira, clindamycin amagwiritsidwa ntchito limodzi ndi pyrimethamine malinga ndi chiwembu chotsatira: 600-1200 mg pamlomo pakadutsa maola 6 aliwonse kwa milungu iwiri, ndiye kuti 300-600 mg pamlomo pakadutsa maola 6 aliwonse. -75 mg pakamwa tsiku lililonse. Nthawi zambiri, njira yochizira ndi masabata 8-10. Mukamagwiritsa ntchito milingo yayikulu ya pyrimethamine, folic acid iyenera kutumikiridwa pa 10 mg mg / tsiku.

Ziphuphu za chibayo za chibayo mwa odwala omwe ali ndi Edzi: 300-450 mg pakamwa maola 6 aliwonse kwa masiku 21 ndipo primaquine 15-30 mg pamlomo kamodzi patsiku kwa masiku 21.

Pachimake streptococcal tonsillitis / pharyngitis: 300 mg pakamwa kawiri pa tsiku kwa masiku 10.

Malungo: 10-20 mg / kg / tsiku pakamwa kwa akulu ndi 10 mg / kg / tsiku kwa ana maola 12 aliwonse Mlingo wa masiku 7 monga monotherapy, kapena kuphatikiza ndi quinine (12 mg / kg maola 12 aliwonse) kapena chloroquine (15-25 mg maola 24 aliwonse) kwa masiku atatu.

Kupewa kwa endocarditis mwa odwala omwe ali ndi chidwi chachikulu cha penicillin: 600 mg pamlomo wa akulu ndi 20 mg / kg kwa ana ola limodzi asanachitidwe opaleshoni ya mano kapena mano kapena njira ina iliyonse yokhudzana ndi chiopsezo cha endocarditis.

Odwala okalamba: palibe chifukwa chosinthira mlingo mwachilungamo (kwa zaka zinazake) chiwindi ndi impso.

Kunja. Gawo loonda la gel limayikidwa m'malo omwe akhudzidwa ndi khungu loyera 2 kawiri pa tsiku. Kuti mupeze zotsatira zogwira mtima, mankhwalawa amayenera kupitilizidwa kwa milungu 6, ndipo ngati ndi kotheka, mutha kupitiliza mpaka miyezi 6.

Mlingo umodzi (wowonjezera 1 wa kirimu (5 g ya kirimu, pafupifupi 100 mg ya clindamycin)) umayendetsedwa mu nyini, makamaka nthawi yogona, kwa masiku atatu kapena 7 otsatizana.

Phukusi lomwe lili ndi 20 g ya kirimu muli omwe amaikapo mapulasitiki atatu, ndipo paphukusi lokhala ndi 40 g pali ofunsira 7 omwe cholinga chake ndi kuyambitsa kirimuyo mu nyini.

Malangizo ogwiritsira ntchito mankhwalawa

1. Chotsani kapu ya chubu cha zonona. Skani piritsi ya pulasitikiyo pakhosi la chubu.
2. Mukakungunulira chubu kuchokera mbali ina, pofinyira zonona ndikuziyika. Wopemphayo amakhala atadzaza pomwe piston yake ikafika.
3. Chotsani wolembetsa ku chubu ndikukulunga chipewa.
4. Mutagona kumbuyo kwanu, kokerani mawondo anu pachifuwa chanu.
5. Kugwira cholembapo, ndikuyiyika mosamala mu nyini mozama momwe mungathere, osayambitsa zosasangalatsa.
6. Pang'onopang'ono kukankhira pisitoni njira yonse, ikani kirimu munyini.
7. Chotsani wofunsayo mosamala kuchokera kumaliseche ndikuchotsa.

Zotsatira zoyipa

• kupweteka kwam'mimba
• kusanza, kusanza,
• kutsegula m'mimba
• esophagitis
• zilonda zam'mimba
• pseudomembranous colitis,
• dysbiosis,
• maculopapular zidzolo,
• urticaria
• kuyabwa
• kuchuluka kwa nyemba zazing'ono kwambiri mpaka pang'ono.
• erythema multiforme,
• exfoliative and vesiculo-bullous dermatitis,
• toxic epidermal necrolysis,
• anaphylactoid zimachitika
• milandu ya neutropenia (leukopenia) ndi eosinophilia yachilengedwe yapita;
• vaginitis
• kukula kwa umunthu wapamwamba.

Contraindication

• Hypersensitivity kuti clindamycin, lincomycin kapena chigawo chilichonse cha mankhwala.

Mimba komanso kuyamwa

Clindamycin amadutsa chikhodzodzo. Pambuyo pa kukhazikitsa zingapo Mlingo wa mankhwalawa, ndende mu amniotic madzimadzi anali pafupifupi 30% ya ndende mu magazi a mayi. Clindamycin iyenera kugwiritsidwa ntchito mwa amayi apakati pokhapokha ngati phindu lomwe limaperekedwa kwa mayi limaposa chiwopsezo cha mwana wosabadwayo. Clindamycin imapezeka mkaka wa m'mawere pamtunda wa 0.7-3.8 μg / ml.

Ngati ndi kotheka, nthawi yoikidwiratu panthawi yoyamwitsa iyenera kusiya kuyamwa.

Malangizo apadera

Pankhani ya matenda amchiberekero a Chlamydia trachomatis, clindamycin monotherapy imathandiza kuchira kwathunthu.

Milandu ya pseudomembranous colitis yamitundu yosiyanasiyana mpaka kuopseza moyo inawonedwa ndikugwiritsa ntchito pafupifupi mankhwala onse a antibacterial, kuphatikiza Dalacin, motero, pazochitika zonse za matenda am'mimba atatha kumwa mankhwala a antibacterial, kuthekera kwa matenda kuyenera kuganiziridwanso. Mankhwala ochepetsa mphamvu ya antibacterial amachepetsa maluwa oyamba a m'matumbo, omwe angathandizire kukulitsa kubzala kwa clostridia. Zatsimikiziridwa kuti poizoni wopangidwa ndi Clostridium Hardile ndiye chifukwa chachikulu cha colitis yokhudzana ndi mankhwala othandizira. Pseudomembranous colitis imatha kuchitika onse atatenga clindamycin, ndipo patatha masabata awiri atayimitsa chithandizo, akuwonetseredwa ndi matenda am'mimba, leukocytosis, malungo, kupweteka kwam'mimba (nthawi zina kumayendera limodzi ndi kupukusira kwa magazi ndi mafinya). Pambuyo pa matenda a pseudomembranous colitis atapezeka mu milandu yofatsa, chithandizo ndi kugwiritsa ntchito ma ion exchange resins (colestyramine, colestipol) ndizokwanira kuzimitsa, pazovuta kwambiri komanso milandu yayikulu, kubwezeretsa kwa kutayika kwa madzimadzi, ma electrolyte ndi mapuloteni, kuyika kwa antibacterial mankhwala othandiza pa matenda a Clostridium, vancomycin mu mlingo wa 125-500 mg, kapena bacitracin muyezo wa 25,000 IU mkati 4 pa tsiku kwa masiku 7, kapena metronidazole 250-500 mg katatu pa tsiku. Mankhwala omwe amachepetsa m'mimba motility sayenera kutumikiridwa nthawi imodzi ndi clindamycin.

Mukamagwiritsa ntchito mankhwala onse a antibacterial, kuphatikiza clindamycin, kukula kwachilengedwe kakang'ono kosaganizira mankhwalawa, makamaka bowa ngati yisiti. Ndi kukula kwamphamvu, njira zoyenera ziyenera kutengedwa kutengera ndi mankhwalawa.

Clindamycin sayenera kutumikiridwa pochizira matenda a meningitis, chifukwa amalowa bwino kudzera mu magazi chotchinga cha magazi (BBB).

Popereka mankhwala muyezo waukulu, ndikofunikira kuwongolera ndende ya plindamycin mu plasma. Ngati chithandizo chikuchitika kwa nthawi yayitali, ndiye kuti kuyesa kwa chiwindi ndi impso kuyenera kuchitidwa pafupipafupi.

Odwala omwe ali ndi vuto la chiwindi ndi impso, palibe chifukwa chosinthira mankhwalawa, popeza clindamycin kwenikweni siziwunjikana m'thupi ngati mankhwalawa atengedwa pakamwa ndi pakadutsa maola 8.

Kuyanjana kwa mankhwala osokoneza bongo

Zakhazikitsidwa kuti mu vitro antagonism pakati pa dalacin ndi erythromycin amawonekera. Popeza kuti kukokomeza kumeneku kungakhale kwakufunika kwakadwala, mankhwalawa sayenera kumwa nthawi yomweyo. Pali umboni wa mgwirizano wofanana ndi chloramphenicol.

Kukhazikitsidwa kuti Dalacin amasokoneza kufalitsa kwa neuromuscular ndipo, chifukwa chake, amatha kupititsa patsogolo mphamvu za ena opuma a minyewa, motero, mankhwalawa ayenera kugwiritsidwa ntchito mosamala odwala omwe amalandila mankhwala a gululi.

Kugwiritsa ntchito nthawi yomweyo opioid (narcotic) analgesics, omwe ali ndi vuto linalake lamphamvu pakupuma, kungayambitse kupsinjika kwakanthawi kokwanira mpaka chifuwa.

Munthawi yomweyo makonzedwe antidiarrheal mankhwala amene amachepetsa m'mimba motility kumaonjezera ngozi ya pseudomembranous colitis.

Aminoglycosides amakulitsa mawonekedwe a antimicrobial zochita za clindamycin.

Mndandanda wa mankhwala Dalacin

Zofanana muzochitika zamagulu:

• Dalacin C phosphate,
• Zerkalin,
• Klimitsin,
• Clindamycin,
• Klindatop,
• Klindafer
• Clindacin
• Klines,
• Klindovit.

Zizindikiro zogwiritsidwa ntchito

Matenda oyambitsidwa ndi bakiteriya omwe amayambitsidwa ndi tizilombo tating'onoting'ono: matenda a ziwalo za ENT (kuphatikiza tonsillitis, pharyngitis, sinusitis, otitis media), matenda opumira (bronchitis, chibayo, zotupa zam'mapapo, kupweteka kwa mafupa, mafupa a khungu osteomyelitis, nyamakazi ya septic), matenda opatsirana a pakhungu ndi minofu yofewa (kuphatikiza ziphuphu, zithupsa, phlegmon, impetigo, panaritium, mabala opatsirana, zotupa, erysipelas), sepsis (makamaka anaerobic), matenda amkati ndi matenda okhudzana ndi intraperitoneal ( kuphatikizaperitonitis, abscesses yam'mimba ziwalo ndi munthawi yomweyo kugwiritsa ntchito mankhwala motsutsana gram-alibe aerobic tizilombo ting'onoting'ono, matenda amkati (endometritis, adnexitis, colpitis, abscesses wa fallopian machubu ndi mazira, salpingitis, pelvic peritonitis, matenda amkamwa abscess), toxoplasma encephalitis, malungo (oyambitsidwa ndi Plasmodium falciparum), chibayo (chifukwa cha Pneumocystis carinii), sepsis, endocarditis, chlamydia, malungo ofiira, diphtheria.

Mlingo

Makapisozi 150 mg, 300 mg

Makapu amodzi ali:

ntchito yogwira - clindamycin hydrochloride 177.515 mg kapena 355.030 mg (ofanana ndi clindamycin 150 mg kapena 300 mg),

zokopa: magnesium yakuwotcha, wowuma chimanga, talc, lactose monohydrate,

kapisozi kapisozi: titanium dioxide (E 171), gelatin.

Makapisozi olimba a gelatin olimba okhala ndi chivindikiro ndi thupi loyera, inki yakuda yosindikizidwa "Pfizer" ndi code "Clin 150". Zomwe zili m'mabotolo ndi ufa woyera (wa mulingo wa 150 mg).

Makapisozi olimba a gelatin olimba okhala ndi chivindikiro ndi thupi loyera, inki yakuda yosindikizidwa "Pfizer" ndi code "Clin 300". Zomwe zili m'mabotolo ndi ufa woyera (wa 300 mg).

Mankhwala

Pharmacokinetics

Pambuyo pakamwa, clindamycin imathamanga ndipo imafikika kwathunthu (90% ya mlingo womwe umamwa).

Zakudya zomwezi munthawi yomweyo sizikhudzanso kuchuluka kwa mankhwalawa m'madzi a m'magazi.

Kuzindikira kwa Serum

Mwa achikulire athanzi, kuchuluka kwa plasma wozungulira kumakhala pafupifupi 2 mg / L ndipo kumawonekera ola limodzi pambuyo pakukonzekera kwa 150 mg ya clindamycin hydrochloride kapena 4-5 mg / L pambuyo pakamwa 300 mg. Kenako, ndende ya plasma imatsika pang'onopang'ono, yotsalira pamwamba pa 1 mg / L kwa maola opitilira 6. Kuzunzidwa kwa plasma kumawonjezeka motsatana malinga ndi kuchuluka kwa mlingo womwe umamwa. Kuzungulira kwa Serum kumanenedwa kuti kumachepera pang'ono kwa odwala matenda ashuga kuposa odwala athanzi. Wachilengedwe wamba theka la moyo wa clindamycin ku seramu ndi maola 2,5.

Kumanga Mapuloteni a Plasma

Kulumikizira mapuloteni a plasma ndikuyambira 80 mpaka 94%.

Kufalitsidwa mu minyewa ndi madzi amthupi

Clindamycin imagawidwa kwambiri m'mazinthu azambiri kwambiri mumadzi am'magulu am'madzi am'mimba komanso amtundu wambiri. Kusiyanitsa mu madzi a cerebrospinal ndizochepa.

Clindamycin imapukusidwa mu chiwindi.

Pafupifupi 10% ya mankhwalawa amagwiritsidwa ntchito mu mkodzo ndipo 3,6% imachotsedwa ndowe. Chotsalacho chimachotseredwa ngati ma metabolites osagwira.

Serum clindamycin wozungulira sasintha monga hemodialysis kapena peritoneal dialysis.

Mankhwala

Malingaliro akumva otsatirawa osachepera mphamvu ya zoletsa (MIC) amagwiritsidwa ntchito kusiyanitsa pakati pazinthu zomwe zikuwoneka, zinthu zomwe zimakhala ndi gawo lapakati, komanso zokhala ndi zofunikira pakati pazinthu zosagwirizana:

S ≤ 2 mg / L ndi R> 2 mg / L.

Kuchuluka kwa kukana kumene kungatengedwe kungasiyane kwa mitundu inayake malingana ndi dera komanso nthawi, ndipo ndikofunikira kuti mukhale ndi chidziwitso pazigawo za kuchuluka kwa kukana, makamaka pochiza matenda oopsa. Chidziwitsochi chimangotipatsa lingaliro lokhazikika la kuthekera kwa chamoyo cha maantibayotiki.

Grram-cocci cocci, kuphatikiza:

-Streptococcus osakhala agulu lililonse

Gram-alibe bacilli, kuphatikiza:

Zabwinoaerobicmabakiteriya

-Yopanda mphamvugram alibebacilli

Clindamycin amawonetsa ntchito mu vitro ndi mu vivo motsutsa Toxoplasma gondii.

* Kuchuluka kwa kukana kwa methicillin pafupifupi 30 mpaka 50% kwa staphylococci onse ndipo kumachitika kwambiri kuchipatala.

Mlingo ndi makonzedwe

Mankhwalawa amagwiritsidwa ntchito mkati, pofuna kupewa kukhumudwa, makapisozi akuyenera kutsukidwa ndi kapu yonse ya madzi (250 ml).

Mankhwala tsiku lililonse ndi 600-1800 mg / tsiku, logawidwa 2, 3 kapena 4 waukulu. Mlingo wambiri watsiku ndi tsiku ndi 2400 mg.

Odwala odwala

Mlingo wa 8-25 mg / kg pa tsiku, logawidwa mu 3 kapena 4 Mlingo wofanana.

Gwiritsani ntchito mwa ana akuwonetsedwa ngati angathe kumeza kapisozi yonse.

Odwala okalamba

Kafukufuku wa Pharmacokinetic atagwira pakamwa kapena kudzera m'mitsempha yamitsempha kapena m'mitsempha yake sanawonetse zofunika zakusiyana pakati pa achinyamata ndi okalamba omwe ali ndi vuto lofanana ndi chiwindi komanso zabwinobwino. Pankhaniyi, kusintha kwa okalamba odwala omwe ali ndi chiwindi chokwanira komanso chobwinobwino (poganizira zaka zapambuyo) ntchito yaimpso siyofunika.

Odwala ndi mkhutu aimpso ntchito

Odwala aimpso kulephera, kusintha kwa clindamycin sikofunikira.

Odwala omwe ali ndi vuto la chiwindi

Odwala ndi hepatic kusowa, kusintha kwa clindamycin sikofunikira.

Mlingo wa zisonyezo zapadera

Chithandizo cha Matenda a Beta Hemolytic Streptococcus

Malingaliro a Mlingo ofanana ndi Mlingo wa pamwambapa wa akulu ndi ana. Chithandizo ziyenera kupitilizidwa kwa masiku osachepera 10.

Chithandizo cha pachimake streptococcal tonsillitis kapena pharyngitis

Mlingo woyenera ndi 300 mg kawiri tsiku lililonse kwa masiku 10.

Kulimbikitsa matenda a kutupa matenda a m'chiuno ziwalo

Mankhwalawa amayenera kuyamba ndi njira yothetsera mtsempha wa magazi Dalacin C Phosphate (pafupifupi 900 mg maola 8 aliwonse osakanikirana ndi ma intravenous antibiotic) mwachitsanzo, ndi gramu-aerobic tizilombo tating'onoting'ono, mwachitsanzo, ndi gramuicin ya 2.0 mg / kg, ndikutsatira. Mlingo wa 1.5 mg / kg maola 8 aliwonse omwe ali ndi matenda abwinobwino aimpso. Kulowetsa mankhwala osokoneza bongo kuyenera kupitilizidwa kwa masiku osachepera 4 komanso maola 48 atadwala.

Kenako, muyenera kupitiliza kumwa Dalacin ® pakumwa 450-600 mg maola 6 aliwonse tsiku lililonse mpaka kumaliza maphunziro onse ndi masiku 10-14.

Mafupa ndi mafupa olowa

Mlingo woyenera ndi 7.5 mg / kg maola 6 aliwonse.

Kupewa kwa endocarditis mwa odwala omwe ali ndi vuto la penicillin

Odwala achikulire, mlingo woyenera ndi 600 mg 1 ola limodzi asanatero, ana: 20 mg / kg 1 ola limodzi asanatero.

Kutulutsa mawonekedwe ndi kapangidwe kake

Dalacin akupezeka mu mitundu yotsatsa iyi:

• Gel yogwiritsira ntchito kunja 1%: yowoneka bwino, yopanda utoto, yowoneka bwino (30 g iliyonse machubu, 1 chubu 1 mtolo wa makatoni),
• Vaginal kirimu 2%: yoyera (20 kapena 40 g iliyonse mwa machubu a polyethylene kapena zojambula zotayidwa zokhala ndi ofunsira atatu kapena 7 (motsatira), 1 yokhazikitsidwa pabokosi la makatoni),
• Makapisozi: gelatinous, kolimba, yokhala ndi thupi ndi chivindikiro choyera, cholembedwa "P&U 225" (150 mg iliyonse) kapena "P&U 395" (300 mg iliyonse), zomwe zili m'mapilogalamuwa ndi ufa woyera (ma 8 kapena 10 ma PC. M'matumba, 2 kapena matuza awiri m'bokosi la katoni),
• Vaginal suppositories: mawonekedwe owoneka ngati torpedo, olimba, okhala ndi mawonekedwe osalala, pafupifupi oyera kapena oyera (ma PC 3. M'mizere ya foil lamonedwe ndi popanda kapena wofunsira, 1 mzere mu chikwama cha makatoni).

Muli ndi 1000 mg wa gel osakaniza:

• The yogwira thunthu: clindamycin (munthawi ya phosphate) - 10 mg,
• Zothandiza: methyl paraben - 3 mg, allantoin - 2 mg, polyethylene glycol - 100 mg, propylene glycol - 50 mg, carbomer 934P - 7.5 mg, yankho la 40% sodium hydroxide - mokwanira, madzi oyeretsedwa - okwanira mpaka 1000 mg .

Kuphatikizidwa kwa kirimu wa chikazi wa 1000 mg:

• The yogwira thunthu: clindamycin (munthawi ya phosphate) - 20 mg,
• Zothandiza: cetyl Palmitate - 32.1 mg, stearic acid - 21.4 mg, polysorbate 60 - 50 mg, sorbitan monstearate - 20 mg, propylene glycol - 50 mg, mowa wa benzyl - 10 mg, mowa wa cetstearyl - 32.1 mg, mchere mafuta - 64.2 mg, madzi oyeretsedwa - okwanira.

Kaphatikizidwe 1 kapisozi:

• Zogwira ntchito: clindamycin (mu mawonekedwe a hydrochloride) - 150 kapena 300 mg,
• Zothandiza: talc, lactose, wowuma chimanga, mphamvu ya magnesium, gelatin, titanium dioxide.

Kuphatikizidwa 1

• Zogwira ntchito: clindamycin (munthawi ya phosphate) - 100 mg,
• Zothandiza: mafuta olimba (Witepsol H-32, osakaniza a monoglycerides, diglycerides ndi triglycerides) - pafupifupi 2400 mg.

Contraindication

Dalacin amatsutsana pamaso pa hypersensitivity kuti clindamycin, lincomycin kapena othandizira pazinthu za mankhwalawa.

Mankhwala mu mawonekedwe a makapisozi ayenera kumwedwa mosamala odwala matenda am'mimba (mbiri), makamaka ndi ulcerative colitis, myasthenia gravis (mwina kusokonezeka kwa kufalikira kwa chiwindi), kufooka kwambiri kwa chiwindi.

Kuphatikiza apo, Dalacin mu mitundu ina ya mankhwala amatsutsana zotsatirazi matenda:

• Mbiri ya colitis yokhudzana ndi maantiotic,
• M'badwo: mpaka zaka 18 zothandizira kirimu chachikazi ndi zowonjezera, mpaka zaka 12 za gel kuti zitha kugwiritsidwa ntchito kunja (palibe zomwe zikuwonetsa kuchuluka ndi chitetezo cha Dalacin m'gululi la odwala),
• Hypersensitivity to lincomycin kapena clindamycin mu anamnesis (wa gel kuti mugwiritse ntchito kunja).

Mlingo ndi makonzedwe

Dalacin mu kapisozi kapiritsi amatengedwa pakamwa. Pofuna kupewa zovuta, tikulimbikitsidwa kuti muzigwiritsa ntchito mosamalitsa monga adanenera dokotala.

Popewa kukwiyitsa mucous membrane wa esophagus, makapisozi amayenera kumwedwa ndi kapu yodzaza ndi madzi.

Mankhwala nthawi zambiri amatengedwa:

• Akuluakulu: 600-1800 mg patsiku, pafupipafupi makonzedwe - 2-4 zina (Mlingo wofanana),
• Ana: 8-25 mg / kg ya kulemera kwa thupi patsiku, pafupipafupi makonzedwe ake ndi katatu (mulingo wofanana).

Pochizira matenda obwera chifukwa cha beta-hemolytic streptococcus, Dalacin amagwiritsidwa ntchito mu Mlingo tafotokozazi. Kutalika kwa njira ya achire ndi masiku osachepera 10.

Chithandizo cha matenda opatsirana komanso otupa a m'chiberekero chimayamba ndi mtsempha wa magazi wa clindamycin, pa 900 mg maola 8 aliwonse, munthawi yomweyo ndi antibacterial woyenera kwa masiku osachepera anayi. Matenda a wodwalayo atatha, mankhwala amapitirirabe kwa masiku ena awiri, pambuyo pake Dalacin amamuika ngati mawonekedwe a makapisozi kamodzi mu 450-600 mg. Mankhwala amatengedwa tsiku lililonse maola 6 aliwonse. Njira yonse ya chithandizo ndi masiku 10-14.

Kutengera ndi umboni, Dalacin adalembedwa:

• Toxoplasmosis encephalitis mu odwala a AIDS: vuto la kulephera kulandira chithandizo chokwanira, mankhwalawa amatengedwa nthawi yomweyo ndi pyrimethamine malinga ndi chiwembu chotsatira: Dalacin - 600-1200 mg maola 6 aliwonse masiku 14, ndiye 300-600 mg ndi pafupipafupi kugwiritsa ntchito, pyrimethamine - tsiku lililonse 25 -75 mg. Monga lamulo, kosi ya chithandizo ndi masabata 8-10. Mukamagwiritsa ntchito pyrimethamine mu Mlingo wapamwamba, 10-20 mg wa folic acid patsiku uyenera kutumikiridwa,
• Matenda a khansa pachifuwa chifukwa cha Chlamydia trachomatis: 450-600 mg tsiku lililonse, mlingo 4 pa tsiku, nthawi ya masiku 10 mpaka 14,
• Acute streptococcal pharyngitis / tonsillitis: kwa masiku 10, 300 mg 2 pa tsiku,
• Pneumocystis chibayo mwa odwala AIDS: masiku 21, 300-450 mg maola 6 amodzi nthawi yomweyo ndi primaquine, 15-30 mg kamodzi patsiku,
• Malungo: achikulire - 10-20 mg / kg patsiku, ana - 10 mg / kg patsiku. Mankhwala amatengedwa chimodzimodzi Mlingo uliwonse 12 maola, nthawi ya maphunzirowa ndi masiku 7. Ndizothekanso kugwiritsa ntchito Dalacin nthawi imodzi ndi quinine (maola 12 aliwonse pa 12 mg / kg) kapena chloroquine (maola 24 aliwonse ali ndi 15-25 mg), kutalika kwa maphunzirowa ndi masiku 3-5.

Pofuna kupewa endocarditis odwala omwe ali ndi hypersensitivity ku penicillin, Dalacin ndi mankhwala: akulu - 600 mg, kwa ana - 20 mg / kg. Mankhwala ayenera kumwedwa ola limodzi musanayambe mano kapena opaleshoni yocheperako, kapena njira ina iliyonse yomwe mungathe kutenga endocarditis.

Okalamba okalamba omwe ali ndi vuto laimpso komanso kwa chiwindi kwa zaka zochepa, komanso odwala omwe ali ndi vuto la chiwindi ndi impso, sayenera kusintha mlingo.

Mankhwalawa bakiteriya vaginosis, zotchulidwa:

• Kirimu wamphesa: 5000 mg ya kirimu (1 wofunsira wathunthu, pafupifupi 100 mg ya clindamycin) ayenera kuyikiridwa mu nyini. Njirayi imachitika bwino nthawi yogona. Kutalika kwa maphunziro - masiku atatu kapena 7,
• Vaginal suppositories: 1 suppository imathandizidwa nthawi imodzi tsiku lililonse patsiku, makamaka asanagone. Maphunzirowa amatenga masiku atatu.

Dalacin mu mawonekedwe a gelisi amagwiritsidwa ntchito kunja pochiza ziphuphu zakumaso. Mankhwalawa amawaika m'mbali yopyapyala kumalo owonongeka (khungu lowuma, loyera). Kuchulukana kwa ntchito - 2 pa tsiku. Kutalika kwa maphunziro kumeneku ndi masabata a 6-8. Malinga ndi zikuwonetsa, kugwiritsa ntchito Dalacin ndikotheka kwa miyezi 6. Ngati, mutatha kugwiritsa ntchito gel osakaniza ndi miyezi ingapo, kugwiritsa ntchito bwino mankhwala kumachepa, yopuma imafunikira kwa masabata anayi.

Zotsatira zoyipa

Mukamagwiritsa ntchito Dalacin mkati, zotsatirazi zimakhala zotsatirazi:

• Matumbo a pakhungu: nseru, m'mimba kupweteka, m'mimba, kusanza, kupweteka pachifuwa cham'mimba, zilonda zam'mimba, jaundice, dysbiosis, kusowa kwa chiwindi, kuphatikizapo hyperbilirubinemia,
• Hematopoiesis (hematopoietic system): zochitika za eosinophilia zodutsa chilengedwe ndi leukopenia (neutropenia), komanso milandu ya thrombocytopenia ndi agranulocytosis, zidadziwika, komabe, palibe mgwirizano pakati pa kayendetsedwe ka Dalacin ndi zochitika izi
• Thupi lawo siligwirizana: pruritus, urticaria, maculopapular, nthawi zambiri zotupa zotupa zolimbitsa kwambiri komanso modekha, kawirikawiri - vesiculobulous and exfoliative dermatitis, erythema multiforme, anaphylactoid reaction,
• Zina: vaginitis.

Komanso mukamalandira chithandizo, zotsatirapo zoyipa zimatha kuchitika: Kukula kwa mphamvu, kufooka kwa mitsempha.

Pochiza bakiteriya vaginosis ndi Dalacin mu mawonekedwe a kirimu wamkati ndi ma suppositories, ndizotheka kukulitsa zovuta m'machitidwe ena a thupi:

• Ntchito yobereka: vulvovaginitis, vagidi candidiasis, kutulutsa magazi mu chiberekero, kukwiya kwa mucous membrane wamkati ndi chala, matenda am'kati, trichomonias vaginitis, kupweteka kwamkati, kubala kosawerengeka, kusamba kwamiseche, kumaliseche, endometriosis,
• Urinary system: kwamikodzo thirakiti matenda, dysuria, proteinuria,
• Matumbo ochita kupindika: kulawa kupota, kusweka, kusanza, kutsegula m'mimba, kusanza, kudzimbidwa, halitosis, kusokonezeka m'mimba,
• Khungu: erythema, kuyabwa, zotupa, khungu, zotupa za maculopapular, urticaria,
• Pakati mantha dongosolo: chizungulire, kupweteka mutu, vertigo,
• Dongosolo la Endocrine: hyperthyroidism, glucosuria,
• Njira yothandizira kupumula: Matenda apamwamba am'mapapo, ma mphuno,
• Thupi lonse: matenda oyamba ndi fungus, mabakiteriya, kumatulutsa, kupweteka kwapakatikati ndi / kapena kupweteka kwam'mimba, kupweteka kwam'mimba, kukokana kwam'mimba, kupatuka kwa zotsatira za kusanthula kwa micobiological kuchokera ku chizolowezi, kupweteka kwakumbuyo, zovuta zina.
• Zomwe zimachitika m'deralo: edema yotupa ndi kuyabwa pamalo a jakisoni.

Mukamagwiritsa ntchito gel osakaniza a kunja, zotsatirapo zoyipazi zingachitike:

• Matumbo a pakhungu: colitis, kupweteka kwam'mimba, matenda am'mimba, matenda am'mimba (kusekera, kutsegula m'mimba, kusanza),
• Gulu la masomphenya: kutentha m'maso,
• Misempha: nthawi zambiri - khungu lowuma, kuchuluka kwa ziwengo za sebaceous, mkwiyo wa pakhungu, urticaria, dermatitis yolumikizana,
• Zina: folliculitis chifukwa cha gram alibe maluwa.

Malangizo apadera

Ndi chitukuko cha matenda otsegula m'mimba mutagwiritsa ntchito Dalacin pakamwa kapena kudzera m'mitsempha, ayenera kuganizira za pseudomembranous colitis. Matendawa amatha kuonekanso patatha masabata awiri atachotsedwa. Zizindikiro zake zazikulu ndi monga: kutsekula m'mimba, leukocytosis, kutentha thupi, kupweteka kwam'mimba (nthawi zina kumayenderana ndi kubisala kwa ntchofu ndi magazi okhala ndi ndowe). Ngati ndi kotheka, njira zoyesera ndi zochiritsira ziyenera kumwedwa.Pogwiritsa ntchito mankhwalawa, mankhwalawa a colitis ndi osowa, komabe, chisamaliro chimayenera kutengedwa ndipo, ngati pakapita nthawi yayitali kapena matenda oopsa, kugwiritsa ntchito mankhwala osokoneza bongo ayenera kusiyidwa.

Pa matenda amchiberekero omwe amayamba chifukwa cha Chlamydia trachomatis, kapisozi kokhala ndi Dalacin ndi othandiza pakumuchiritsa kwathunthu.

Mukamamwa Dalacin mkatikati, kukula kwambiri kwa tizilombo tosakhudzana ndi mankhwalawa ndikotheka, makamaka bowa ngati yisiti. Pankhani yakukondweretsedwa, kutengera matendawo, njira zoyenera ziyenera kuchitidwa.

Clindamycin sayenera kutumikiridwa pochizira matenda a meningitis.

Mukapereka mankhwala a Dalacin muyezo waukulu, muyenera kuwongolera kuchuluka kwa matenda a m'magazi a plindamycin. Ndi chithandizo cha nthawi yayitali, kuyesedwa kwa impso ndi chiwindi kuyenera kuchitidwa.

Tizilombo toyambitsa matenda totsatirawa tiyenera kuyikonza tisanapange mankhwala a Dalacin pochiza matenda a vulvovaginitis: Chlamydia trachomatis, Trichomonas vaginalis, Candida albicans, Neisseria gonorrhoeae ndi Herpes simplex virus.

Tiyenera kudziwa kuti kugwiritsa ntchito mankhwala mosokoneza bongo kungapangitse kukula kwa ma tizilombo ochepa osaganizira zochita zake, makamaka bowa ngati yisiti.

Pogwiritsa ntchito mankhwalawa intravaginal, kuyenera kupewa kupewa, komanso kugwiritsa ntchito mitundu ina ya mankhwala omwe amaperekedwa kudzera mu intravaginally (mwachitsanzo, syringes, tampons).

Kugwiritsa ntchito Dalacin ngati kirimu kapena supplementory pa nthawi ya msambo osavomerezeka. Chiyambireni chamankhwala pamilandu iyi iyenera kukhazikitsidwa mpaka kumapeto kwa msambo.

Dalacin imakhala ndi zinthu zomwe zimakhudza kulimba kwa mphira kapena zopangira ma fakitala (kulera modumphira m'mimba, makondomu). Kugwiritsa ntchito zinthu zoterezi munthawi ya mankhwala ndipo pakatha masiku atatu mutatha kugwiritsa ntchito mankhwalawa osavomerezeka.

Pewani kulumikizana ndi gel kuti mugwiritse ntchito michere pakamwa ndi m'maso. Mukatha kugwiritsa ntchito mankhwalawa, sambani m'manja mosamba. Ngati mwakumana mwangozi ndi zoteteka pamalo (abrasions pakhungu, maso, mucous nembanemba), muzimutsuka bwino ndi madzi ozizira.

Kuyanjana kwa mankhwala osokoneza bongo

Clindamycin sayenera kumwedwa pakamwa nthawi yomweyo ndi erythromycin ndi chloramphenicol.

Pali mtanda wotsutsana ndi tizilombo tating'onoting'ono tambiri to lincomycin ndi clindamycin.

Clindamycin iyenera kugwiritsidwa ntchito mosamala mu odwala omwe amalandila zopuma zina za minofu.

Ndi kugwiritsa ntchito pamodzi kwa Dalacin mkati ndi opioid (narcotic) analgesics omwe ali ndi vuto linalake lakulepheretsa kupuma, kukhazikika kwa kupuma komwe kumanenedwa mpaka kupumira.

Chiwopsezo chotenga pseudomembranous colitis chimawonjezeka ndi kugwiritsa ntchito pamodzi kwa Dalacin ndimankhwala osokoneza bongo omwe amachepetsa m'mimba.

Kuwonekera kwa antimicrobial kwa clindamycin kumakulitsidwa ndi aminoglycosides.

Kugwiritsa ntchito munthawi yomweyo zonona zamkati mwa mayi ndi zina ndi mankhwala ena osokoneza bongo sizikulimbikitsidwa.

Ma Analogs a Dalacin ndi awa: Klindatsin, Klindes, Klindamitsin, Klindovit, Klindatop.

Makapisozi Dalacin C

Mtengo wa makapisozi - kuyambira 1324 p.

Makapisozi amakhala ndi talc, lactose ndi magnesium stearate ngati zida zothandizira. Chipolopolocho chinagwiritsa ntchito wowuma, titanium dioxide ndi gelatin.

Yoyamba ndi makapu. Amatha kukhala unyinji wa 150 kapena 350 mg. Makapisozi ndi olimba, khungu la thupi ndi chivindikiro ndi lofiirira kapena loyera, utoto wa ufa womwe mkati umayera.

Yankho la jakisoni

Mtengo wa Dalacin C mwa njira yothetsera jakisoni umachokera pa 587 r pa mulingo wokwanira.

Pothetsera jakisoni, zinthu zina ndi madzi a jekeseni, disodium edetate, benzyl mowa.

Ampoules akhoza kukhala ndi 2, 4 kapena 6 ml ya yankho. Amadzimadzi alibe mtundu. Ili m'mipanda yopangidwa ndigalasi lopanda utoto la kalasi yoyamba.

Kuchita ndi njira zina

Malangizo a mankhwalawa akuti akhoza kukhudza ma pharmacokinetics a mankhwala ena.

Chifukwa chake, imatha kukweza kwambiri zotsatira za minofu yopumula thupi. Chifukwa chake, kugwiritsa ntchito mankhwalawa kumachitika nthawi yomweyo kuyang'aniridwa ndi dokotala. Mlingo wa mankhwalawa onse umasinthidwa payekhapayekha.

Ngati mumagwiritsa ntchito mankhwala othana ndi matenda a m'mimba komanso a Dalacin C nthawi imodzi, ndiye kuti chiwopsezo cha colitis chikuwonjezeka.

Ndi zoletsedwa kugwiritsa ntchito mankhwalawa, malangizo omwe amafotokozedwa m'nkhaniyi, kuphatikizapo calcium gluconate, barbiturates, erythromycin, aminophylline, ampicillin, magnesium sulfate.

Zotsatira zoyipa

Mukamamwa mankhwalawa, zizindikiro zambiri zosasangalatsa zimatha kuchitika.

Kuchiza ndi antibayotiki kungayambitse:

• Kupweteka kwam'mimba
• Kusanza ndi kusanza
• Kutsegula m'mimba
• Esophagitis
• Dysbacteriosis
• Supombocytopenia
• Leukopenia
• Agranulocytosis
• Eosinophilia
• Vaginitis
• Zotupa pakhungu, ming'oma, ndi kuyabwa
• Kufooka kwa thupi
• Chizungulire
• Apnea
• Kuthamanga kwa magazi

Pogwiritsa ntchito makapisozi kwa nthawi yayitali, zilonda zam'mimba zimayamba.

Nthawi zina, maantibayotiki amatha kupweteketsa vuto la khungu.

Momwe thupi lawo siligwirizana ndi mankhwalawa limatha kuwoneka ngati mantha anaphylactic.

Mutha kuphunzira zambiri za momwe mungaimitsire kutsegula m'mimba m'nkhaniyi: kulimbana ndi matenda am'mimba.

Bongo

Milandu yama bongo osokoneza bongo sanalembetsedwe.

Komabe, ngati simutsatira mlingo, chiopsezo cha anaphylactic chikuwonjezeka kwambiri. Kuti athetse izi, mankhwala a antihistamines ndi glucocorticoid amagwiritsidwa ntchito, komanso adrenaline. Mphamvu ya hemodialysis pochitika anaphylactic zimachitika ndi zero. Palibe mankhwala enaake a Dalacin C.

Migwirizano ndi magwiritsidwe akusungidwa

Malangizo a mankhwalawa akuti muyenera kuyika malo amdima ndi chinyezi chokhazikika. Kutentha kosungirako kumatha kukhala madigiri 15 mpaka 25 Celsius.

Moyo wa alumali mu mawonekedwe a capule ndi miyezi 60.

Mankhwala mu mawonekedwe a yankho la jakisoni amatha kugwiritsa ntchito miyezi 24 kuyambira tsiku lopangira.

Akrikhin OJSC (RF) kapena Pharmaprim LLC (Moldova)
Mtengo - kuchokera 207 r

Zomwe zimagwiritsidwa ntchito ndizofanana ndi mankhwala omwe amafunsidwa. Amapezeka mu mawonekedwe a ukazi suppositories kapena zonona.

Ubwino:

• Yothandiza kwambiri ku bacteric vaginosis, chifukwa imagwiritsidwa ntchito mopangika
• Kirimu ndi mawonekedwe omwe ndi osavuta kugwiritsa ntchito.

Chuma:

• Kugwiritsa ntchito zowonjezera sikothandiza kwa aliyense
• Sipapezeka piritsi.

Clindamycin

Nizhpharm (Serbia)
Mtengo - kuchokera 167 r

Zomwe zimagwiritsidwa ntchito ndizofanana mankhwala. Amapezeka mu kapisozi kapamwamba.

Ubwino:

• Fomu ya Mlingo (makapisozi) ndi yosavuta kugwiritsa ntchito.
• Mtengo ndi wotsika.

Chuma:

• Contraindified mu mimba
• Zotsatira zoyipa zofanana ndi Dalacin C.

Momwe mungagwiritsire ntchito: Mlingo ndi njira ya chithandizo

Mkati, akulu: 150 mg maola 6 aliwonse, m'matenda oopsa, mlingo umodzi umatha kuwonjezeka mpaka 300-450 mg wa mankhwalawa. Ana: 8-25 mg / kg / tsiku (kutengera zovuta za matendawa), logawidwa pakati Mlingo wa 3-4.

Mankhwalawa colpitis chifukwa Chlamydia trachomatis, 450 mg zotchulidwa 4 pa tsiku kwa masiku 10-14.

Mu / m kapena mu / mu: akulu - 300 mg kawiri pa tsiku. Kwa matenda opatsirana - 150-300 mg 2-4 kawiri pa tsiku, kwa matenda oopsa - 1.2-2.7 g / tsiku la jakisoni a 2-4. Ndi matenda oopsa m'moyo, mlingo wa iv umatha kuchuluka mpaka 4,8 g / tsiku.

Ana analamula 10-40 mg ya mankhwala / kg / tsiku, ogaŵikana 3-4 Mlingo.

Kwa iv makonzedwe, onjezerani ku ndende yosaposa 6 mg / ml, yankho limayendetsedwa limaperekedwa kwa iv pakukanda kwa mphindi 10-60.

Dilution dongosolo ndi nthawi ya kulowetsedwa: mlingo, kuchuluka kwa zosungunulira ndi nthawi ya kulowetsedwa (motero): 300 mg - 50 ml - 10 min, 600 mg - 100 ml - 20 min, 900 mg - 150 ml - 30 min, 1200 mg - 200 ml - Mphindi 45 Kukhazikitsidwa kwa oposa 1.2 g pa ola limodzi la kulowetsedwa sikulimbikitsidwa.

Njira yothetsera vutoli imagwiritsidwa ntchito mkati mwa maola 24 kuchokera tsiku lokonzekera. Mankhwalawa colitis oyambitsidwa ndi Clostridium zovuta, nthawi yomweyo kuphatikiza ndi vancomycin kwa masiku 10 500 mg - 2 g patsiku, logawidwa 3 kapena 4 Mlingo wofanana.

Odwala omwe ali ndi vuto lambiri laimpso / kwa chiwindi amafunika kusintha kwa mlingo.

Zotsatira za pharmacological

Antibiotic a gulu la lincosamides. Ili ndi mawonekedwe ambiri ochitira, bacteriostatic, yomwe imamangiriza mpaka gawo la 50S la membrane wa ribosomal ndipo imalepheretsa kuphatikizika kwa mapuloteni mu cell yaying'ono. Poyerekeza ndi cocci zingapo zabwino za cocci, zotsatira za bactericidal ndizotheka. Yogwira motsutsana ndi Staphylococcus spp. (kuphatikiza penicillinase yotulutsa Staphylococcus epidermidis), Streptococcus spp. (kupatula Enterococcus spp), Streptococcus pneumoniae, Corynebacterium diphtheriae, spore- komanso-spore-form anaerobes, ndi microaerophilic gram-positive cocci (kuphatikiza Peptococcus spp. ndi Peptostreptococcus spp. Clostridium perfrinrate. (kuphatikizapo Bacteroides fragilis ndi Prevotella melaninogenica), Fusobacterium spp., Propionibacterium spp., Eubacter spp., Actinomyces spp.

Mitundu yambiri ya Clostridium perfringens imakhudzidwa ndi mankhwalawa, komabe, popeza mitundu ina ya clostridia (Clostridium sporogenes, Clostridium tertium) imagwirizana ndi mankhwalawa, kutsimikiza kwa maantibayotiki kumalimbikitsidwa chifukwa cha matenda omwe amayamba chifukwa cha Clostridium spp.

Matenda osagwirizana ndi Mycoplasma chibayo, Haemophilus fuluwenza, Helibacter pylori, Neisseria meningitidis, Neisseria gonorrhoeae, Ureaplasma urealyticum.

Kutsutsa kwamtanda kumakhalapo pakati pa Dalacin C ndi lincomycin. Kuthandiza mankhwalawa asymptomatic diphtheria (mlungu uliwonse maphunziro, pakamwa).