Kodi glucophage amachepetsa bwanji ntchito?

Hypoglycemic (wotsitsa magazi glucose) wothandizira.

France, Spain, kusakhazikika ndi kuwongolera kwapamwamba - RF "Nanolek".

Imapezeka mu mawonekedwe a mapiritsi ozungulira omwe amaphimbidwa ndi chipolopolo (chopyapyala), biconvex. Gawo likuwonetsa yunifolomu yoyera.

• metformin hydrochloride (500/850 / 1000mg).

• povidone
• magnesium wakuba,
• hypromellose (membrane wamafilimu).

Makatoni oikidwa, mapiritsi amtundu wa blasters.

Pharmacological zochita za glucophage

The yogwira zigawo zikuluzikulu za mankhwala Glucophage kumalimbikitsa shuga, kuwonjezera zotumphukira zolandilira sensulin, kuchepetsa hyperglycemia ndi ziletsa hepatic gluconeogeneis. Kumwa mankhwalawa kumachepetsa kuchuluka kwa triglycerides, cholesterol yathunthu, lipoprotein yotsika kwambiri ndikuchepetsa kuyamwa kwa matumbo m'mimba.

Glucophage metroformin yayitali, yomwe ndi gawo la Glucophage, imakhudza mwachindunji glycogen synthetase, yomwe imapangitsanso kaphatikizidwe ka glycogen ndikuwonjezera kuthekera kwa mayendedwe a glucose membrane.

Fomu lamasulidwe a Glucophage

Malinga ndi malangizowo, Glucofage imapangidwa ngati mapiritsi oyera okhala ndi biconvex yoyera yozungulira yokhala ndi mawonekedwe oyera oyera pamtanda. Piritsi limodzi la Glucofage lili ndi:

• Povidone - 20 mg kapena 34 mg,
• Metformin hydrochloride - 500 mg kapena 850 mg,
• Magnesium stearate - 5.0 mg kapena 8.5 mg.
• Nembanemba wamafilimu amakhala ndi 6.8 mg wa hypromellose.

Glucophage imapangidwanso ngati mapiritsi okhala ndi biconvex yoyera yoyera yokhala ndi notch mbali zonse ziwiri, zolembedwa ndi "1000" mbali imodzi ndikuyera loyera paliponse pamtanda.

Piritsi limodzi la Glucofage lili ndi:

• Metformin hydrochloride - 1000 mg,
• Povidone - 40 mg
• Magnesium stearate - 10 mg.
• Utoto wamafilimu umakhala ndi 90.90% ya hypromellose, 4.550% ya macrogol 400 ndi 4.550% ya macrogol 8000.

Glucophage yayitali imapangidwa ngati mapiritsi oyera a biconvex oyera kapena ofunikira ngati "500" mbali imodzi, 15 ma PC. ma cell muma contour mumapaketi a makatoni.

Piritsi limodzi lalitali la Glucophage lili ndi:

• Metformin hydrochloride - 500 mg,
• Hypromellose 2208,
• Carlone sodium
• Microcrystalline mapadi,
• Hypromellose 2910,
• Magnesium wakuba.

Glucophage yayitali imapangidwanso mawonekedwe a biconvex yoyera kapena yoyera yokhala ngati biconvex ya nthawi yayitali polemba "750" yokhala ndi chimodzi ndi cholembedwa "Merck" mbali inayo, 15 ma PC. ma cell muma contour mumapaketi a makatoni.

Piritsi limodzi lalitali la Glucophage lili ndi:

• Metformin hydrochloride - 750 mg,
• Hypromellose 2208 - 294.24 mg,
• Magnesium stearate - 5.3 mg,
• Sodium Carmellose - 37,5 mg.

Glucophage analogues

Glucophage ndi Glucophage kutalika kwa kanthu kogwira ntchito ndi:

• Bagomet,
• Forin Pliva,
• Glyformin
• Diaformin,
• Nova Met
• Langerine
• Sofamet
• Methadiene
• Fomu,
• Metfogamma,
• Metformin teva
• NovoFormin,
• Siofor 1000,
• Metformin MV-Teva.

Zisonyezero zogwiritsira ntchito glucophage

Malinga ndi malangizo, Glucophage imagwiritsidwa ntchito ngati matenda a shuga 2 mwa akulu ndi ana azaka zopitilira 10 (kuphatikiza insulin), komanso kunenepa kwambiri ndi kukana kwa insulin.

Mapiritsi a Glucophage amatchulidwa kuti apatsidwe matenda a shuga a 2 komanso osagwiritsa ntchito mankhwala olimbitsa thupi mwa akulu, osakanikirana ndi insulin komanso monotherapy.

Chomwe chimadziwikanso ndikugwiritsa ntchito Glucofage pakuchepetsa thupi, yomwe kuphatikiza ndi zakudya zochepa zopatsa mphamvu komanso zolimbitsa thupi zimakuthandizani kuti mukwaniritse zotsatira mwachangu kwakanthawi. Komabe, mutha kugwiritsa ntchito Glucofage kuti muchepetse thupi kokha pazolinga zomwe mukuyang'anira komanso moyang'aniridwa ndi katswiri wazakudya.

Njira yogwiritsira ntchito Glucofage ndi mlingo

Malinga ndi malangizo, Glucophage imatengedwa pakamwa, kutsukidwa ndi madzi musanadye kapena nthawi ya chakudya ndi monotherapy ndikumaphatikizira pamodzi ndi othandizira ena a hypoglycemic.

Mlingo woyambirira wa mankhwalawa mu achikulire ndi 500 mg kawiri patsiku ndi kuwonjezeka kwa mlingo, kutengera kuchuluka kwa shuga m'magazi. Mulingo wambiri watsiku ndi tsiku sayenera kupitirira 3000 mg patsiku ndipo agawikidwe pazigawo zitatu.

Mapiritsi a Glucophage amatengedwa pakamwa, osafuna kutafuna, pakudya ndi monotherapy komanso kuphatikiza mankhwala ndi othandizira ena a hypoglycemic. Mlingo wa mankhwalawa amawerengedwa potengera zomwe zimapangidwa ndi shuga m'magazi am'magazi. Mlingo woyambirira wa mankhwalawa ndi 500 mg kamodzi patsiku.

Contraindication

Malinga ndi malangizo, Glucophage ndi Glucophage nthawi yayitali amalembedwa mu:

• Matenda ashuga ketoacidosis,
• Matenda a shuga
• Matenda a shuga
• Matenda a impso,
• Kuthetsa madzi m'thupi
• Thupi
• Matenda opatsirana owopsa,
• Matenda omwe angayambitse kukula kwa minofu hypoxia,
• Kuchepa kwa chiwindi,
• Uchidakwa wambiri
• Lactic acidosis
• Kutsatira zakudya zamafuta ochepa
• Mimba komanso kuyamwa,
• Hypersensitivity pamagawo a mankhwala.

Zotsatira zoyipa za glucophage

Malinga ndi ndemanga, Glucophage ikhoza kuyambitsa mavuto osiyanasiyana machitidwe osiyanasiyana amthupi, awa:

• Kuwonongeka Kwa Matenda (CNS),
• Kusanza, kupweteka kwam'mimba, kusowa kudya komanso kusanza (kugaya chakudya),
• Rash, pruritus, ndi erythema (matupi awo sagwirizana),
• Lactic acidosis ndi vitamini B12 hypovitaminosis (metabolism),
• Kuchepa kwa chiwindi ndi hepatitis (hepatobiliary system).

Komanso, malinga ndi ndemanga, Glucophage ngati mankhwala osokoneza bongo amatsogolera chizungulire, kupweteka kwa minofu, kusokonezeka kwa chikumbumtima, kutsegula m'mimba, kutentha thupi komanso kupuma mofulumira.

Malinga ndi ndemanga, Glucophage yayitali imayambitsa zotsatirapo zomwezo monga Glucofage.

Pharmacokinetics wa mankhwala.

Mutatha kumwa mankhwalawo mkati, metformin imatenga gawo lonse la chakudya. Ndi kuyamwa kwa munthawi yomweyo, kuyamwa kwa metformin kumachepetsedwa ndikuchedwa. Mtheradi bioavailability ndi 50-60%. Cmax mu plasma imakhala pafupifupi 2 μg / ml kapena 15 μmol ndipo imafikiridwa pambuyo maola 2,5.

Metformin imagawidwa mwachangu mu minofu ya thupi. Sizikugwirizana ndi mapuloteni a plasma.

Amachepetsa pang'ono ndi kupukusidwa ndi impso.

Kuvomerezeka kwa metformin mwa anthu athanzi ndi 440 ml / min (kanthawi kuposa KK), komwe kumawonetsa katulutsidwe ka tubular.

T1 / 2 ndi pafupifupi 6.5 maola.

Mlingo ndi njira ya mankhwala.

Monotherapy ndi kuphatikiza mankhwalawa ndi ena othandizira pakamwa

Akuluakulu, mlingo woyambirira ndi 500 mg 2-3 nthawi / tsiku mutatha kapena mukudya. Kuwonjezereka kwapang'onopang'ono kwa mlingo kumatha kutengera kuchuluka kwa shuga m'magazi.

Njira yokonza tsiku ndi tsiku ndi 1500-2000 mg / tsiku. Kuti muchepetse mavuto kuchokera m'matumbo, mankhwalawa amayenera kugawidwa pakamwa katatu. Mlingo wapamwamba wa tsiku ndi tsiku ndi 3000 mg / tsiku, logawidwa pazigawo zitatu.

Kuchepetsa pang'ono kwa mankhwalawa kungathandize kusintha kulolerana kwa m'mimba.

Odwala omwe atenga metformin mu Mlingo wa 2000-3000 mg / tsiku amatha kusamutsidwa kupita ku Glucofage 1000 mg. Mlingo woyenera kwambiri ndi 3000 mg / tsiku, womwe umagawidwa pazigawo zitatu.

Ngati mukufuna kusintha kuti muthane ndi mankhwala a Glucofage ndi wothandizanso wina wa hypoglycemic, muyenera kusiya kumwa mankhwalawa ndikuyamba kumwa Glucophage muyezo womwe tafotokozawu.

Kuphatikiza kwa insulin

Kukwaniritsa bwino glycemic control, metformin ndi insulin zitha kugwiritsidwa ntchito ngati mankhwala ophatikiza.

Mlingo woyambirira wa mankhwala Glucofage mu mlingo wa 500 mg ndi 850 mg ndi 1 tabu. 2-3 nthawi / tsiku, Mankhwala Glucofage muyezo wa 1000 mg ndi 1 tabu. 1 nthawi / tsiku Mlingo wa insulin umasankhidwa potengera zotsatira za kuyeza magazi.

Mwa ana opitirira zaka 10, glucophage angagwiritsidwe ntchito onse mu monotherapy komanso kuphatikiza insulin. Mlingo woyambirira ndi 500 mg katatu / tsiku mukatha kudya kapena musanadye. Pambuyo masiku 10-15, mlingo uyenera kusinthidwa kutengera zotsatira za kuyeza magazi. Mulingo wambiri watsiku ndi tsiku ndi 2000 mg, wogawidwa pamitundu iwiri.

Odwala okalamba, chifukwa cha kuchepa kwa ntchito yaimpso, mlingo wa metformin uyenera kusankhidwa poyang'aniridwa nthawi zonse owonetsa aimpso (kuwunika kwa serum creatinine osachepera 2-4 pachaka). Sitikulimbikitsidwa kugwiritsa ntchito mankhwalawa kwa odwala azaka zopitilira 60 omwe amagwira ntchito zolimbitsa thupi.

Zotsatira zoyipa Glucophage:

Pafupipafupi zotsatira zoyesazi zimawerengedwa motere: pafupipafupi (1/10), nthawi zambiri (1/100, contraindication:

Kuwonongeka kwa impso (CC Gwiritsani ntchito pakati ndi pakati.

Mankhwalawa amayesedwa kuti agwiritse ntchito panthawi yoyembekezera komanso panthawi yoyamwitsa.

Mukakonzekera kapena poyambitsa kutenga pakati, glucophage iyenera kusiyidwa ndipo mankhwala a insulin atchulidwa. Wodwala ayenera kuchenjezedwa za kufunika kodziwitsa dokotala ngati ali ndi pakati. Amayi ndi mwana ayenera kuyang'aniridwa.

Sizikudziwika ngati metformin yachotsedwa mkaka wa m'mawere. Ngati ndi kotheka, ntchito mankhwalawa pa mkaka wa m`mawere ayenera kusiya kuyamwitsa.

Malangizo apadera ogwiritsira ntchito glucophage.

Wodwalayo ayenera kuchenjezedwa za kufunika kosiya kumwa mankhwalawo ndikuwonana ndi dokotala ngati kusanza, kupweteka kwam'mimba, kupweteka kwa minofu, kufooka kwapafupipafupi ndi kuonekera kwambiri. Zizindikiro izi zitha kukhala chizindikiro cha kulowerera lactic acidosis.

Glucophage iyenera kuyimitsidwa maola 48 isanachitike komanso mkati mwa maola 48 atawunika X-ray (kuphatikiza urography, intravenous angiography) ogwiritsa ntchito ma radiopaque othandizira.

Popeza metformin imachotsedwa mu mkodzo, milingo ya serum creatinine iyenera kutsimikizika musanayambe chithandizo ndi mankhwalawa komanso pafupipafupi.

Kusamala makamaka kuyenera kuchitika ngati vuto laimpso likuwonekera, mwachitsanzo, munthawi ya chithandizo cha antihypertensive mankhwala, okodzetsa, NSAIDs.

Mudziwitse wodwalayo za kufunika kofunsa dokotala ngati zikuoneka kuti muli ndi matenda a bronchopulmonary kapena matenda opatsirana a genitourinary.

Potengera momwe mankhwalawa amagwiritsidwira ntchito mankhwalawa Glucofage, munthu ayenera kupewa kumwa mowa.

Kugwiritsa Ntchito Kwa Ana

Mwa ana opitirira zaka 10, glucophage angagwiritsidwe ntchito onse mu monotherapy komanso kuphatikiza insulin.

Kukopa pa kuyendetsa magalimoto ndi kayendedwe kazinthu

Monotherapy yokhala ndi Glucophage sichimayambitsa hypoglycemia chifukwa chake sichikhudza kuthekera koyendetsa galimoto ndikugwira ntchito ndi zida. Komabe, odwala ayenera kusamala za chiopsezo cha hypoglycemia mukamagwiritsa ntchito metformin molumikizana ndi othandizira ena a hypoglycemic (kuphatikizapo zotumphukira za sulfonylurea, insulin, repaglinide).

Mankhwala osokoneza bongo:

Zizindikiro: mukamagwiritsa ntchito Glucofage pa mlingo wa 85 g, hypoglycemia siinawoneke, komabe, lactic acidosis idadziwika. Zizindikiro zoyambirira za lactic acidosis ndi mseru, kusanza, kutsegula m'mimba, kutentha thupi, kupweteka m'mimba, kupweteka kwa minofu, mtsogolomo kumatha kuwonjezera kupuma, chizungulire, chikumbumtima chovuta, komanso kupweteka.

Chithandizo: Kutha msanga kwa Glucofage, kuchipatala mwachangu, kutsimikiza ndende ya lactate m'magazi, ngati kuli kotheka, kuchita mankhwala. Kuchotsa lactate ndi metformin m'thupi, hemodialysis imakhala yothandiza kwambiri.

Glucophage mogwirizana ndi mankhwala ena.

Ndi munthawi yomweyo kugwiritsa ntchito mankhwala Glucofage ndi danazole, kukula kwa vuto la hyperglycemic ndikotheka.Ngati mankhwala a danazol akufunika ndipo atayimitsa, kusintha kwa Glucofage kumafunika muulamuliro wa glycemia.

Ndi munthawi yomweyo kugwiritsa ntchito mankhwala Glucofage ndi zakumwa zoledzeretsa ndi ethanol, chiopsezo chotenga lactic acidosis panthawi yoledzera ya mowa umachulukirachulukira, makamaka mukasala kudya kapena kutsatira zakudya zochepa zopatsa mphamvu, komanso ngati chiwindi chikulephera.

Kuphatikiza komwe kumafunikira chisamaliro chapadera

Chlorpromazine mu Mlingo wambiri (100 mg / tsiku) amachepetsa kutulutsa insulin ndikuwonjezera kuchuluka kwa shuga m'magazi. Pogwiritsa ntchito munthawi yomweyo ma antipsychotic ndipo atayimitsa makina awo, kusintha kwa Glucofage kumafunika muulamuliro wa glycemia.

GCS (yogwiritsidwa ntchito mwa makina ndi apakhungu) imachepetsa kulolera kwa shuga ndikuwonjezera kuchuluka kwa shuga m'magazi ena, amachititsa ketosis. Ngati mukufunika kugwiritsa ntchito kuphatikiza koteroko, ndipo mutayimitsa kuyendetsa gCS, kusintha kwa Glucofage kumafunikira motsogozedwa ndi glucose level.

Pogwiritsa ntchito munthawi yomweyo mankhwala a "loop" okodzetsa komanso Glucofage, pamakhala chiopsezo cha lactic acidosis chifukwa chowoneka ngati kulephera kwaimpso. Glucophage sayenera kufotokozedwa ngati QC ndi mikhalidwe yogulitsa m'masitolo.

Mankhwala ndi mankhwala.

Migwirizano yosungirako ya mankhwala Glucofage.

Mankhwalawa amayenera kusungidwa kuti ana asawatenthe pa kutentha osaposa 25 ° C. Alumali moyo mapiritsi a 500 mg ndi 850 mg ndi zaka 5. Moyo wa alumali wa mapiritsi a 1000 mg ndi zaka zitatu.

Masiku ano, anthu ambiri akakhala kuntchito komanso kuntchito atangokhala moyo wovuta, vuto la kunenepa kwambiri mdziko latha. Popeza alibe mphamvu kapena kuthekera kuchezerako masewera olimbitsa thupi ndi kudya moyenera, amadalira zakudya zopatsa thanzi zingapo komanso mankhwala omwe amati amathandizanso kulemera.

Ndipo Glucophage ndi amodzi mwa mankhwala otere. Koma kodi ndiwothandiza ngati momwe amatsatsa amasonyezera? Ndipo kodi kudya kwake kudzasandulika mavuto akulu mtsogolo? Tiyeni tiyese kuzindikira.

Glucophage. Mlingo

Mapiritsi oyendetsera pakamwa (pakamwa).

Amagwiritsidwa ntchito ngati monotherapy kapena mankhwala ophatikiza (poika ena othandizira a hypoglycemic).

Gawo loyamba ndi 500 mg ya mankhwalawa, nthawi zina 850 mg (m'mawa, masana, ndi madzulo pamimba yonse.

M'tsogolomu, mlingo umakulitsidwa (monga momwe amafunikira komanso pokhapokha mukaonana ndi dokotala).

Kuti mukhalebe achire mothandizidwa ndi mankhwalawa, tsiku lililonse mlingo umafunikira - kuyambira 1500 mpaka 2000 mg. Mlingo woletsedwa kupitirira 3000 mg ndi pamwamba!

Kuchuluka kwa tsiku ndi tsiku kumagawika katatu kapena kanayi, komwe ndikofunikira kuti muchepetse zovuta.

Zindikirani Ndikofunikira kuwonjezera kuchuluka kwa tsiku lililonse kwa sabata, pang'onopang'ono, kuti mupewe zoipa. Kwa odwala omwe adamwa kale mankhwala ophatikizika ndi Metformin ochulukirapo kuyambira 2000 mpaka 3000 mg, mapiritsi a Glucofage ayenera kumwedwa pa mlingo wa 1000 mg patsiku.

Ngati mukufuna kukana kumwa mankhwalawa omwe amakhudza mafupa a hypoglycemic, muyenera kuyamba kumwa mapiritsi a Glucofage muyezo wochepetsedwa, momwe mungapangire monotherapy.

Tulutsani mitundu ndi ma fanizo

Mu 2017, Glucophage imagulitsidwa ngati mapiritsi oyera a biconvex ozungulira ndi mulingo wa chinthu chogwira (metformin hydrochloride): 500, 850 ndi 1000 mg. Amadzaza zidutswa 10 chilichonse m'matumba, pomwe 10, 15 kapena 20 akhoza kukhala mu katoni imodzi. Alumali moyo wa mankhwalawa ndi zaka 3, kutentha kosaloledwa kovomerezeka ndi 15 ° -25 ° C.

Mankhwala mumatha kupeza Glucofage Long - mtundu wa mankhwala omwe ali ndi mphamvu yayitali (yayitali). Mlingo wa metformin mmenemo ndi 500 mg, ndipo gawo la opezawo ndi sodium carmellose, magnesium stearate, hypromellose 2208 ndi 2910, komanso cellcrystalline cellulose. Zomwe zimapangidwira zimathandizira kuti ziwalo zogaya chakudya zimatenga nthawi yochulukirapo kuti zimveke zomwe zimagwira, zomwe zikutanthauza kuti zidzakhala zokwanira komanso zochepa zomwe zingatenge.

Mwa zina mwazofanana za Glucofage, otchuka kwambiri ndi:

Ndi mankhwala ati oti musankhe? Ngati tikuwona mankhwalawa ngati mankhwala a hypoglycemic, ndiye kuti lingaliro lomaliza lidzakhala kwa adotolo. Ngati zotsatira za kuchepetsa thupi zili patsogolo, ndiye kuti ndibwino kuti musankhe, kuyambira pazotsatira zochepa zoyipa za mankhwalawo komanso kuuma kwawo.

Ngakhale kuphatikiza kwa kukonzekera kwa analog kuli pafupifupi kofanana (metformin imayambitsa kuchepa kwa mphamvu zonsezo), zokutira zingapo za shuga, utoto, ndi zina zothandizira (zomwe sizimagwira gawo lofunikira monga zowonjezera) zimatha kukhala ndi magawo osiyanasiyana a kuyeretsa, motero zotsatira zina zoyipa.

Mfundo yogwira ntchito

Glucophage amatanthauza mankhwala a hypoglycemic. Chifukwa cha kapangidwe kake Metformin, mankhwalawa amachepetsa chiwonetsero cha hyperglycemia m'thupi, osathandizira pakukula kwa hypoglycemia.

• imakhazikitsa kagayidwe ka lipid pochepetsa milingo ya triglycerides, cholesterol yathunthu ndi LDL (lipensens lipotroteins),
• zimawonjezera kukhudzika kwa zotumphukira zolandilira kumankhwala angapo achire (mwachitsanzo, insulin),
• imalimbitsa maselo a minyewa kuti ayambe kutulutsa shuga,
• Amachepetsa mayamwidwe am'mimba ndi matumbo ndi gluconeogene omwe amapezeka m'chiwindi.

Ichi ndi mankhwala othandiziridwa. Chifukwa chake, adokotala ndi adotolo ayenera kudziwa kuchuluka kwa mankhwalawo komanso njira yomwe ili yoyenera kwa thupi lanu. Kudziimira pawokha pazinthu izi kuli ndi zowawa kwambiri (mpaka imfa).

Malangizo apadera omwe angagwiritsidwe ntchito pa matenda ashuga ndi awa:

1. Mankhwalawa amaloledwa kumwa, onse osakanikirana ndi mankhwala ena, popanda kudziyimira pawokha.
2. Kumwa glucophage ndikwabwino kwambiri pakudya, kumwa madzi ambiri owiritsa osakhala ndi mpweya wambiri m'chipinda.
3. Pofuna kuchepetsa chiwopsezo cha mavuto komanso kuthana ndi njira yogwiritsa ntchito mankhwala am'mimba kuti apatsidwe mankhwala, kuwonjezereka kwa mlingo kuyenera kuchitidwa mwadongosolo. Kumayambiriro kwa maphunzirowa munthu wamkulu, mlingo (nthawi imodzi) sayenera kupitirira 500 mg.
4. Tsiku lililonse, wodwalayo ayenera kumwa pafupifupi 1,500 mpaka 2,000 mg wa mankhwalawo. Mulingo wovomerezeka tsiku lililonse ndi 3000 mg.
5. Kuti tikwaniritse kuchuluka kwa glucose m'magazi, ndikofunikira kuphatikiza glucophage ndi insulin.
6. Odwala omwe ndi okalamba kapena sanakwanitse kukhala achikulire, sizikulimbikitsidwa kumwa mankhwalawo. Komabe, ngati pakufunika izi, ndikofunika kuyang'aniridwa kwambiri ndi ntchito ya impso ndi serum creatinine.

Tikukumbutsani kuti Glucophage ndi mankhwala amphamvu, chifukwa chake kufunikira koyambirira ndi dokotala ndikofunikira!

Zisonyezero zogwiritsira ntchito glucophage

Glucophage cholinga chake ndikugwiritsa ntchito osati kungochepetsa thupi, komanso kukonza thanzi, kupewa komanso kupewa kukula kwa kunenepa kwambiri ndi matenda ena. Ndizofunikira kudziwa kuti chida ichi sichikhudzanso kuwonongeka kwa minofu ya adipose, koma zimathandizira kuchepetsa mafuta amthupi pochepetsa chilimbikitso, kuletsa kuyamwa kwa mafuta, komanso kuchepetsa kuchuluka kwa shuga m'misempha yam minofu.

Kugwiritsa ntchito shuga kumawonetsedwa kwa anthu omwe akufuna:

• shuga wamagazi
• matenda kagayidwe
• kusintha mayamwidwe a michere ndi thupi,
• chotsani mapaundi owonjezera,
• cholesterol yotsika.

Kuphatikiza apo, kugwiritsa ntchito chida ichi kumathandizira kupewa kukula kwa matenda monga matenda a shuga, stroke, kugunda kwa mtima, kuwopsa kwa magazi ndi matenda ena amtima. Komabe, chifukwa cha izi, glucophage iyenera kutengedwa mosamalitsa ndi madokotala.

Momwe mungamwere glucophage kuti muchepetse kunenepa

Masiku ano, glucophage yayitali ndi njira imodzi yotchuka kwambiri yochepetsera kunenepa.Uwu ndi mtundu wina wa mankhwala omwe amapezeka ndi dzina lomweli, lomwe lili ndi zovuta komanso lalitali pochita, lomwe limasiyana ndi zida zamakono. Mutha kuphunzira momwe mungatengere glucophage kutalika kwa thupi mwa kuphunzira malangizo a mapiritsi. Poganizira kuti chinthu chachikulu chomwe chimapangidwira kumtengowu chimatengedwa nthawi yayitali, piritsi imangotengedwa kamodzi 1 patsiku. Mutha kudziwa kuchuluka kwa mankhwalawa pa intaneti, koma ziyenera kukumbukiridwa kuti mtengo wa mapiritsi oterowo ukwera pang'ono.

Tcherani khutu! Mapiritsi amayenera kudyedwa mosamalitsa ndi zakudya, kutsukidwa ndi madzi pang'ono. Mukamagwiritsa ntchito mankhwalawa pamimba yopanda kanthu, chiopsezo cha zotsatira zoyipa chikuwonjezereka, mwanjira iyi, mapiritsi amawonongeka ndipo amatengedwa nthawi yayitali.

Kuphatikiza apo, ziyenera kudziwika kuti pali mitundu ingapo ya ndalama zomwe zidafotokozedwazi. Glucophage yochepetsa thupi imatha kukhala ndi mitundu yosiyanasiyana: 850, 500, 750, 1000 mg. Mulingo woyenera kwambiri wa kunenepa ndi 500, 750 ndi 850 mg. Mlingo wa 1000 mg ndi chida champhamvu ndipo amalimbikitsidwa kuti azigwiritsidwa ntchito pokhapokha ngati dokotala ali ndi vuto ngati mlingo wa tsiku lililonse wa chinthu uyenera kukhala 2000 mg kapena kupitilira.

Ndemanga za kuchepetsa kunenepa

Tatyana wazaka 30: Ine ndekha sindinkakumana ndi kufunika koonda, koma amayi anga anali ndi vuto lolemera. Zidachitika kuti, potengera tsogolo lazakudya zambiri, adapezeka kuti adakweza shuga, adotolo adapereka shuga kuti itsike magazi. Zinapezeka kuti mankhwalawa amakhudzanso njira yochepetsera thupi, chifukwa nthawi yomwe amatenga makapisozi, amayi anga adataya pafupifupi 20 kg! Adapeza izi pafupifupi miyezi 4. Shuga wabwerera mwakale, kunenepa kwambiri kumatha, amayi akumva bwino. Ndakhuta!

Evgeny Pavlovich, wa zaka 52: Glucophage adandiuza adotolo atapeza shuga wokwera m'magazi. Ndinkakwiya komanso ndimawopa matenda ashuga, kupatula ine ndinalipo onenepa kwambiri. Mwina motsutsana ndi izi, pali ngozi ya matenda ashuga. Pambuyo pakupita makapu, shuga adatsika ndikubwinobwino, koma kunenepa kwambiri kunachepa kwambiri. M'malo mwa mimba yayikulu, ndangotsala khungu, kuyenda kumakhala kosavuta, magawo a chakudya adachepera. Ndine wokondwa kuti glucophage sanandithandizenso kuwonjezera thanzi langa, komanso kuchepa thupi.

Tonsefe timafuna kukhala okongola komanso oonda. Tonsefe timayesetsa kuchita izi - wina mwadongosolo komanso pafupipafupi, winawake nthawi ndi nthawi, pomwe kulakalaka kulowa mu mathalauza okongola kumakulitsa chikondi cha makeke komanso sofa yofewa. Koma nthawi ndi nthawi, ayi, ayi, ndipo panali lingaliro lopenga: ndizachisoni kuti simungatenge piritsi yamatsenga ndikuchotsa mavitamini owonjezera osachita masewera olimbitsa thupi ndi zakudya ... Koma bwanji ngati piritsi loterolo lilipo kale, ndipo limatchedwa Glucofage? Poyerekeza ndi ndemanga zina, mankhwalawa amagwira ntchito ngati zozizwitsa zenizeni zakuchepetsa!

Glucophage - mankhwala a shuga kapena njira yochepetsera kunenepa?

Ndizachisoni, koma owerenga amayenera kukhumudwitsa nthawi yomweyo, omwe atha kusintha magwiridwe osavuta ndi kulemera kambiri: Glucofage sinapangidwe konse kuti aliyense athe kukwaniritsa zomwe zingatheke posachedwa, koma ngati njira yothandizira matenda ashuga. Ntchito yake yayikulu ndikuchepetsa kupanga kwa insulin mthupi, kusintha matendawa m'magazi ndikonzanso njira za metabolic. Zowona, Glucophage imaperekabe vuto lina lochepa thupi, chifukwa limasokoneza mayamwidwe am'madzi ndikuwachepetsa chidwi cha kudya. Koma musaiwale kuti, choyambirira, ndi njira yokonzekera zamankhwala, ndipo muyenera kuigwiritsa ntchito mozama.

Kodi mankhwalawa amagwira ntchito bwanji?

Tisanamve zomwe zochita za Glucophage zimakhazikika, tiyeni tikumbukire chifukwa chake kunenepa kwambiri kumachitika.

Zakudya zamagalimoto zikafika m'mimba yathu limodzi ndi chakudya ndikugaya mashupi osavuta, kenako zimatengedwa m'magazi kudzera m'matumbo a m'mimba, chiwindi chimawatenga.Mothandizidwa ndi iwo, ma monosaccharides amasinthidwa kukhala glucose ndipo amagawidwa kudzera mu maselo amthupi ndi mtsempha wamagazi, komwe amalumikizidwa ndi insulin yomwe imapangidwa ndi kapamba. Ndi chithandizo chake, glucose amasinthidwanso - nthawi ino kukhala mphamvu yofunikira pamoyo. Ngati titha kuwononga ndalama, ndizodabwitsa: machitidwe onse amagwira ntchito moyenera, minyewa imagwirizananso, ndipo thupi limakhala ndi thanzi komanso thanzi. Koma ngati timadya zoposa zomwe tikhoza kudya, chamoyo champhamvu chimayambira, mophiphiritsa, kukankha mphamvu zochulukirapo kudzera muming'alu yonse momwe muli mawonekedwe osanjikiza. Choyamba, minyewa ya chiwindi ndi minofu imakhala malo ake osungira, kenako zotchinga zosavuta m'mbali, pamimba, kumbuyo, ndi kulikonse komwe zingatheke. Zipatso za ntchito zosaletseka zomwe timaziwona pagalasi.

Kodi glucophage imagwira ntchito bwanji? Chifukwa cha metformin yake, imathetsa njirayi mwachangu, mongoletsa kuyamwa kwa monosaccharides m'magazi. Popeza chiwindi chiribe chilichonse chotulutsa shuga kuchokera panonso, thandizo la insulini silifunikiranso ndipo mtengo wake wopangira ukuchepa. Mphamvu sizipanga kuchuluka komweko, koma thupi zimafunikirabe! Atataya zomwe zimafunikira mwanjira zonse, pakapita kanthawi amayamba "kumasula" malo ake osungirako ndikutulutsa mphamvu kumankhwala am'mafuta omwe amapezeka kwa iye. Njira yochepetsera thupi imayamba, momasuka, koma molimba mtima, koma m'njira:

• shuga wamagazi ochepa
• zombo zimayeretsedwa pama cholesterol,
• ngozi ya matenda amtima yachepa,
• lipid metabolism imakulitsidwa,
• chilala chimagwa.

Zikumveka zabwino? Osathamangira kukondwa, mbiya ya uchi yotchedwa "Glucophage" pali zigawo zingapo za phula.

Choyamba, muyenera kukhalabe ndi zakudya. Menyu wokhala ndi zakudya zambiri umapangitsa ntchito yonse ya Glucophage kuti mukhalebe komwe muli - shuga, shuga ndi mafuta.

Kachiwiri, tikukumbutsaninso: simulimbana ndi zakudya zamavuto, koma mankhwala azovuta omwe ali ndi zotsatila zambiri. Mwa njira, tiyeni tikambirane za iwo padera.

Contraindication ndi zoyipa

Glucophage ndi yoletsedwa kugwiritsidwa ntchito:

• anthu odwala matenda ashuga a mtundu 3
• kwa omwe apezeka ndi vuto lililonse la impso,
• odwala omwe ali ndi vuto la m'mimba,
• azimayi pa nthawi yoyembekezera komanso pakubala,
• anthu omwe akudwala mowa (mowa ndi Glucofage sugwirizana),
• kumwa mankhwalawa kumapangitsa kuti zikhale zosatheka komanso tsankho la munthu pazigawo zake.

Koma ngakhale simuli m'gulu lililonse la izi, sizitanthauza kuti thupi lanu lidzamwa mankhwalawo “ndi manja otseguka”. Glucophage nthawi zambiri imabweretsa zotsatira zosasangalatsa mwa anthu athanzi kwathunthu:

• kukoma kunali mkamwa mwanga
• nseru
• kusanza
• chizungulire
• kupuma movutikira
• ukufalikira
• kudula m'mimba
• kutsegula m'mimba
• kutopa,
• kupweteka kwa minofu
• makamaka muzovuta - kusokonezeka kwa chikumbumtima.

Kodi mungapewe bwanji zonsezi? Yankho lake ndi losavuta: pangana ndi dokotala ndikutsatira mosamalitsa malangizo ake.

Ngati kulandira kwa Glucofage kumayambitsidwa ndi matenda aliwonse, kuchuluka kwake ndi nthawi ya chithandizo zimatsimikiziridwa ndi dokotala payekhapayekha komanso kangapo kasinthidwe mogwirizana ndi thanzi la wodwalayo. Chithandizo chotere chimatenga nthawi yayitali - kuyambira miyezi ingapo mpaka chaka kapena kupitirira apo.

Ngati mankhwalawa adangogwiritsidwa ntchito kuti muchepetse thupi ... komabe musakhale aulesi kuyang'ana endocrinologist. Ndizotheka kuti dokotalayo sangakane lingaliro lanu ndikukuthandizani kusankha mlingo womwe ndi wabwino kwa thanzi lanu. Koma ngati akana kukupatsani malangizo a Glucophage kwa inu, adzayenera kutero - adotolo amadziwa bwino.

Kodi mwasankha, mwakuwopsa kwanu komanso pachiwopsezo, kuchita popanda thandizo la katswiri? Ngakhale zili choncho, samalani kutsatira malamulo oyamba achitetezo.

• Tengani Glucophage mosamalitsa mukamadya kapena mukangomaliza kudya.
• Osakaniza kuphatikiza kwa mankhwalawa ndi zakumwa zoledzeretsa, komanso mankhwala othandizira okodzetsa komanso ayodini.
• Osatafuna phukusi kapena kumeza piritsi, kumeza lonse ndikumwa kumwa ndi madzi ochepa (100-200 ml) a madzi wamba.
• Osamayeserera kuchita masewera olimbitsa thupi - izi zimatha kuyambitsa matenda oyamba omwe amatchedwa lactic acidosis. Koma osanama pabedi - yambani kuyenda, muzitsuka pafupipafupi, m'mawu amodzi, kusuntha.
• Sinthani ku chakudya chamafuta ochepa. Atsikana ena, atazindikira kuti Glucophage ndi mtundu wa "kumira m'madzi", nthawi imeneyi amayamba kutsamira kwambiri maswiti - akuti, bwanji osadziletsa ngati piritsi lozizwitsa litulutsa chilichonse! Kodi ndikofunikira kunena kuti chogwirizira chokwanira cha zomwe nthawi zambiri chimakhala chofanana ndi zero?
• Ngati kulekanitsidwa ndi kulemera kochepa mpaka 5 makilogalamu kukonzekera, njira ya kumwa mankhwalawa imayambira masiku 18 mpaka 22. Kuwerengeredwa kilo kukafika pa makumi, nthawi yakuvomerezedwa imapitilira miyezi iwiri. Chulukitsani chiwerengero ichi, ngakhale simunafikire kulemera kumene mukufuna, simungathe.

Mukamamwa mankhwalawa, muyenera kuwunikira nthawi zonse momwe mukusinthira thanzi lanu. Ngati zotsatirapo zoyipa zimatchulidwa kwambiri ndikupangitsa vuto lalikulu, ndibwino kukana kugwiritsa ntchito Glucofage. Kwa wolimbikitsa wogwira ntchito yochepetsa thupi, zinthu zitha kutha mosavuta ndi ambulansi!

Munthawi imeneyi, ndibwino kukhala ndi mita ya glucose yakumanja yowunikira kuchuluka kwa shuga m'magazi. Kapenanso perekani mayeso ofunikira musanayambe kuchepera thupi. Kumbukirani kuti ntchito yayikulu ya Glucophage ndikuchepetsa kuchuluka kwa insulin m'magazi. Mankhwala ake azichitira nawo zoyamba, ngakhale mutakhala kuti mukuyembekezera chiyani.

Yambani kudziwana ndi Glucofage pang'onopang'ono, ndi Mlingo wocheperako: izi zimachepetsa mwayi wazotsatira zoyipa. Nthawi zambiri njira yovomerezeka ya "woyamba" ndi 500-1000 mg patsiku (mapiritsi 1-2 a 500 mg omwe amamwa m'mawa ndi madzulo). Ngati thupi limatenga modekha, pakatha sabata sabata iliyonse imakwezedwa 1500 mg, ndipo sabata lina mpaka 2000 mg. Ndikwabwino kutsatira kumapeto kwa mankhwalawa, ngakhale muzochitika zina zimachulukitsidwa mpaka 3000 mg (mapiritsi atatu okhala ndi chipembedzo cha 1000 mg amatengedwa kawiri kapena katatu masana). Mlingo uwu umatengedwa kuti ndi wokwera kwambiri, sungathe kupitirira.

Nkhani yapadera ndi Glucophage Long-Act. Poyerekeza ndi mankhwala omwe amagwiritsidwa ntchito masiku onse, amakamwa pang'onopang'ono ndipo amalowa m'magazi pang'ono ndi pang'ono, chifukwa chake zochita za piritsi limodzi zimatha tsiku lonse, ndipo zotsatirapo zake sizachilendo. Mlingo wa Glucophage Long umatsimikiziridwa chimodzimodzi monga momwe zimakhalira ndi mankhwala "apamwamba".

Chilichonse chomwe ma epic anu a "matsenga" amatha pamapeto, mutatha kumwa, onetsetsani kuti mupumula kwa miyezi 1.5-2, osachepera. Kulibwino pitani muzakudya chamagulu, ndipo simuyenera kubwerera ku Glucophage.

Malingaliro a madotolo

Madokotala nthawi zonse amalimbikitsa Glucophage osati kwa eni “osangalala” omwe ali ndi matenda a shuga 2, komanso kwa anthu omwe ali ndi cholesterol yambiri, komanso omwe ali ndi kunenepa kwambiri. Koma panthawi imodzimodzi, ali osavomerezeka pamalingaliro ogwiritsa ntchito mankhwalawa kuti achepetse thupi pazokha, popanda kukhala ndi umboni wazachipatala.

Sikuti ndizopusa kugwiritsa ntchito mankhwala oopsa osafunsa dokotala - Glucofage imatha kupondereza kaphatikizidwe ka insulin yanu kwa nthawi yayitali, kusokoneza chiwindi ndi impso komanso kupereka munthu wopanda nkhawa wambiri ndi gulu lonse la matenda owopsa - sizothandiza nthawi zonse. Ndiye kuti, mutha kudzipereka pang'onopang'ono kuti thupi lanu likhale pachiwopsezo chachikulu komanso osamva chilichonse.

Pomaliza, ngakhale mankhwala omwe atchulidwa ataphunziridwa kwathunthu ali ndi mwayi wosokoneza wodwalayo.Ndiye chifukwa chake Glyukofazh ndi wotchuka kwambiri chifukwa cha "mavuto" ake osangalatsa kwambiri! Koma ngati chithandizo chikuchitika moyang'aniridwa ndi katswiri, zoyipa sizingachitike. Dokotala amasintha machitidwe a kuvomereza, kusintha mlingo wa mankhwalawo kapena kuikonzanso ina. Kupita kukasambira pawokha, mumatenga udindo wonse, ndipo ndani adziwa komwe kuyesedwa koyeserera komwe kumakupatsani thanzi lanu? Mwina molunjika pabedi la chipatala?

Kanema: zabwino za metformin, gawo lalikulu la glucophage

"- mankhwala omwe amalembera odwala matenda a shuga a mtundu II. Kugwiritsa ntchito mankhwalawa kumakhala kothandiza kwambiri makamaka ngati matenda oyambitsidwa ndi matendawa amatenga kunenepa.

Unali chuma chomaliza cha mankhwalawo chomwe chidapangitsa kuti Gulcofage igwiritsidwe ntchito kuwonda. Ma pharmacological wothandizila ndi mapangidwe ake angagwiritsidwe ntchito ngati mitundu ya mankhwala a monotherapy, komanso osakanikirana ndi mankhwala ena. Kuwerengera kwabwino ambiri kumabweretsa chikhumbo cha anthu ambiri kuti azigwiritsa ntchito polimbana ndi kunenepa kwambiri, koma dziwani kuti kutenga Glucofage popanda upangiri wa dokotala kungayambitse ngozi yayikulu.

Ndemanga za Odwala

Odwala ambiri omwe amathandizidwa ndi Glucofagem ali ndi mayeso abwino a mankhwala othandizira.

Pofuna kukhala ndi cholinga, zotsatirazi ndizowunika komanso zabwino za anthu omwe amamwa mankhwalawa kuti achepetse thupi:

Lena - "... nditatha miyezi itatu nditatenga Glucophage 500, ndidataya ma kilogalamu atatu. Panalibe zovuta zam'mimba, koma masiku oyamba kusanza pang'ono, koma posakhalitsa mseru unayima. Ndinamwa piritsi katatu patsiku. ”

Ada - "... Ndinkangotenga miyezi itatu ndipo Glyukofazh amathandiza kwambiri. Anasiya kudya soseji ndi soseji, anasinthana ndi masamba ndipo anataya 10 kilogalamu. Patatha mwezi umodzi, kulemerako kunabwereranso, makamaka chifukwa chodya kwambiri mafuta. Ndikuopa kuti, ngati kumwa mankhwalawo nthawi zonse, zimadalira iye. ”

Marta "" ... Ndakhala ndikuyang'ana Glucophage 850 kwa masiku 4. Kulakalaka kwatsika ndipo ndikuyenda tsiku lililonse kwa kilomita osachepera 5.0. Kwa masiku anayi, kulemera kwake kunachepa kuchoka pa 84,5 mpaka 81.8 kilogalamu. Zotsatira zake zoyipa, ndimakhala ndi nseru pang'ono, zomwe sizibweretsa mavuto ambiri. "

Denis - "Kwa zaka 1.5 ndimamwa mankhwalawa, ndidachepetsa 121.0 mpaka 87.0 kilogalamu. Simudziwa kuti chisangalalo ndi chiyani. ".

Alenka "" ... ndimamwa ndikufunsidwa ndi endocrinologist wa matenda a shuga. " Kumayambiriro kwa chithandizo, samaganiziranso kuti Glucofage ingathandizenso kuchepetsa thupi, ndipo adokotala sananene chilichonse chokhudza izi. Tsopano ndimangolandira zodwala zokha komanso kuchepa thupi, sindionanso. Kuti ndichepe thupi, ndimalimbikitsa kuchita masewera olimbitsa thupi komanso kusiya kudya zakudya zopanda pake. ”

Irina "Ndidamwa mankhwala awa ndipo ndazindikira kuti nditha kuchepetsa thupi - kunenepa kwambiri kumatha mofulumira. Adataya ma kilogalamu 8.0 m'miyezi iwiri yopanda chakudya kapena kumenya kwanyonga. Nthawi yomweyo, kunalibe kuwonongeka m'moyo wabwino. Tsopano ndinakana kutero - zotsatira zake zakwaniritsidwa, koma thupi mulibenso poizoni. "

Nika - "... mzanga adatenga Glucophage kuti achepetse kulemera, ndipo kulemera kwake kunachepa ndi 26.0 kilogalamu kuposa miyezi inayi. Mnzake anasangalala kwambiri ndi mankhwalawo ndipo sanawonetsetse zotsatirapo zake. ”

Irina - "... Mwamuna wake anali wolemera kilogalamu 120, dotolo adamulembera" Glucophage "ndipo osachita. Amuna anga anasiya kumwa mapiritsi ndi mowa, adapita kumasewera ndikupitiliza kudya. Kwa theka la chaka adaponya ma kilogalamu 31.0. ”

Vlada "" ... Ndimamwa mankhwalawo nthawi zonse, ndipo ndimawakonda. " M'chaka chamankhwala, pang'onopang'ono adachotsa kunenepa kwambiri. Chopweteketsa mtima ndichakuti kuchepa thupi kumachepera ... "

Irina - "Ndamwa mankhwalawo kwa masiku 12. Zadolbali zoyipa - makamaka kutsekula m'mimba ndi mseru pafupipafupi. Palibe chilakolako cha thupi konse, ndipo kulemera sikumachepetsedwa. Kufooka mu mzimu ndi thupi ndi lingaliro lotere lomwe lidatha zaka zana limodzi.Mankhwalawa adapangidwa ndi dokotala wazamankhwala. Ndikuganiza kuti chemistry yonseyi yochepetsa thupi ndi yopanda pake. Tiyenera kuwunika m'mamawa m'mawa ndipo chilichonse chidzakhala "Chabwino" ... ".

Njira yamachitidwe

Mankhwala "Glucophage" amathandizira kuchepetsa kuchuluka kwa ma sakramenti osiyanasiyana m'magazi, ndipo ndi katundu uyu ndiye maziko a matenda a matenda ashuga.

Ndi kuchepa kwa shuga, glucose sasintha kukhala minofu ya adipose, chifukwa chake sichithandiza kukulitsa kulemera kwa thupi. Chifukwa cha izi, osewera ambiri amagwiritsa ntchito mankhwalawa kuti "aume" matupi awo.

Kumwa mankhwala pafupipafupi kumakuthandizani kuti muchepetse cholesterol m'thupi.

Mphamvu yochepetsera thupi imakonzedwa bwino ngati kudya Glucofage kumaphatikizidwa ndi kumwa kwa carb wotsika komanso zakudya zotsekemera. Chifukwa chake, mankhwala osokoneza bongo amayenera kuthandizidwa ndi chakudya chomwe cholinga chake ndi kuchepetsa kunenepa kwambiri.

"Glucophage" samangochepetsa kuchuluka kwa shuga, komanso imakweza mulingo wosiyanasiyana wa ma cell enaake ndi insulin, potero imapangitsa kuti kagayidwe kachakudya kazigawo ka thupi.

Zotsatira zake, kuchuluka kwa mafuta m'thupi sikumachitika, ndipo mafuta omwe adalipo kale "amawotchedwa" kwambiri. Odwala ambiri omwe alandila chithandizo choyambirira ndi Glucofage amadandaula kuti khungu lonyansa pamimba ndi matako.

Malinga ndi ofufuza akunja ochokera ku Cardiff University (Cardiff University), kutsika kwa kuchuluka komwe kunachitika atamwa mankhwalawo Metformin (analogue ya ku Britain ya Glucofage) kumachepetsa chiopsezo cha kuphwanya myocardial ndi 38% ndikuwoneka kuti akutha ndi 40%.

Kuchepetsa thupi kwa odwala matenda ashuga kumawonedwa mu 41% ya milandu.

Komabe, anthu omwe ali ndi kulemera kowonjezereka ayenera kugwiritsa ntchito mankhwalawa pokhapokha atakumana ndi dokotala komanso kupimidwa. Ngati kumwa mankhwalawa ndikofunikira kwa odwala matenda ashuga, ndiye kuti munthu wodzipaka yekha, yemwe amadzimangiriza yekha, akhoza kuyipitsa thanzi lake.

Madokotala ambiri aku Russia sakonda kumwa mankhwalawa, omwe amangofuna kuchepetsa thupi. M'malingaliro awo, Glucophage adapangidwira zolinga zosiyana kwathunthu ndipo kugwiritsa ntchito mosalamulirika kumatha kuvulaza thanzi la munthu. Ndipo

Ndizachidziwikire chifukwa chake mankhwalawa omwe amapezeka m'mafamu aku Russia angathe kupezeka ndi malangizo a dokotala, ndipo omwe amadya zakudya zambiri amakana kuti odwala awongoleredwe ngati wotsiriza akufuna kugwiritsa ntchito kokha kuwonda.

Makina ogwiritsira ntchito

"Glucophage", monga mankhwala aliwonse ochepetsa thupi, ayenera kumwedwa pokhapokha mukaonana ndi dokotala ndikupereka mayeso oyenera a thupi komanso mayeso odutsa.

Nthawi yomweyo, munthu ayenera kukhala wokonzekera zomwe endocrinologist ikhoza kuletsa kumwa mankhwalawa, kupereka njira zina zothandizira m'malo mwake, ndipo wogulitsa zakudya, akuvomereza "Glucofage".

Nthawi zambiri, njira yodziwika imodzi yotsatirira kumwa imatenga masiku 10 ... masiku 21. Ndi zabwino komanso kusakhalapo kwa zovuta, kukonzanso kwa mankhwalawa kumayamba pakatha miyezi iwiri.

Ndi kugwiritsidwa ntchito pafupipafupi kwa Glucophage, pakhala pali zovuta zina zokhudzana ndi thupi, pomwe kagayidwe kokwanira mthupi kamafuna kukhazikitsidwa kwina kwa Mlingo wa metformin.

Kwa wodwala aliyense yemwe akufuna kuchepa thupi, mankhwalawa amasankhidwa payekha. Zimatengera zaka za munthu, kulemera kwake, kudziwiratu kwake matenda ena. Poyamba, kumwa kamodzi kwa mapiritsi a Glucophage 500 amaperekedwa usiku wonse. Pokhapokha ngati pali zovuta zina ndikuwonjezera kuchuluka kwa mankhwalawa, tiyeni titenge piritsi lachiwiri - piritsi la 500 milligram musanadye nkhomaliro komanso musanakagone.

Mukamalandira chithandizo, wodwala ayenera kukana kumwa ma muffin, madzi otsekemera, zakudya zopatsa mphamvu zamagetsi zomwe zimapezeka mosavuta.Zakudya za Instant, makamaka chimanga ndi pasitala, siziyenera kuyikidwa kunja. Palibe choletsa pazomwe zili ndimchere komanso zonunkhira mu zakudya. Nthawi zambiri, mukamamwa mankhwalawa, simupatsidwa zakudya zapadera, komabe, akatswiri azakudya amalimbikitsa kuti pakhale chakudya chamagulu ochepa.

Zotsatira zoyipa

Malinga ndi zotsatira zofalitsidwa za kafukufuku waposachedwa wa malonda ndi kafukufuku wazakudya zomwe zachitika kuzipatala za Health ndi zipatala zamankhwala monga zotsatira zoyipa, mawonetsedwe otsatirawa a zotsatira za Glucofage adadziwika kwambiri, omwe nthawi zambiri amapezeka nthawi yoyambirira yamankhwala.

1. Kuchokera ku dongosolo lamanjenje lamkati kuyanʻanila kumverera kwa kukoma kumadziwika.
2. Matumbo oyenda Momwe timatha kuwonekera ndi mawonekedwe a kusanza, maonekedwe a mseru komanso kupweteka kwam'mimba, ndikudontha.
3. Thupi lawo siligwirizana amawonetsedwa kawirikawiri ndipo amawonetsedwa ndi mawonekedwe a zotupa, kuyabwa pakhungu, mwapadera mwa mawonekedwe a eczema.
4. Mwa omwe ali ndi vuto la chiwindi Zizindikiro za hepatitis zitha kuchitika.

Ngati chimodzi mwazizindikirozi chikuwoneka, muyenera kufunsa dokotala yemwe ayenera kudziwa ngati angagwiritsenso ntchito mankhwalawo kapena kupereka mankhwala ochepetsa.

Ngakhale ndemanga zabwino ndi malingaliro ambiri omwe adatumizidwa pa intaneti, musadzichepetse pogwiritsa ntchito Glucofage. Kulumikizana ndi katswiri, dokotala woyenera sangakuthandizireni kudziwa mulingo woyenera komanso kusankha njira yoyenera yamankhwala, komanso kukupulumutsani ku zotsatira zosayembekezereka.

Zofananira, zogwirizana kwambiri ndi mankhwalawa ndi awa:

1. Bagomet (Bagomet) , opanga Quimica Montpelfer - Argentina, kampani ya Valeant Limited Liability - Russia,
2. "Metfogamma" ("Metfogamma") - "Woerwag Pharma" - Germany,
3. Nova Met - "Novartis Pharma" - Switzerland, "LEK" - Poland,
4. Siofor - "Berlin-Chemie / Menarini Pharma" - Germany,
5. "Formetin" ("Formetin") - "Pharmstandard-Leksredstva" - Russia.

Mu kanema "Sportloto-82" ngwazi ya Mikhail Kokshonov anafunsa: "Kodi mungadye zipatsozi?" . Omwe San Sanych Murashka, ngwazi ya Mikhail Pugovkin, adayankha: "Mutha kupangidwapo chiphe" . Sitinanene pachabe mwambowu. Chowonadi ndi chakuti Glucofage 500, 850 ndi 1000 mg sanapangidwe kuti achepetse thupi, koma kuti athandize odwala matenda ashuga. Komabe, anthu onenepa kwambiri anayamba kumwa mankhwalawa. Mankhwalawa amatha kupweteka. Kuphatikiza pa lead. Komabe, Glucophage pakuchepa kwa izi sikuti amasiya kumwa. Funso nkulondola "Kodi ungatero kapena ayi?" . Tiyesera kuyankha.

Kuthandiza odwala matenda ashuga, Mankhwala Glucofage adapangidwa, omwe, kuphatikiza pakuchepetsa kuthamanga kwa shuga m'magazi, amakhala ndi zotsatira zoyipa - amawotcha mafuta. Inde, pakati pa odwala matenda ashuga, kunenepa kumachitika kawirikawiri. Tsopano tiyeni tikambirane magwero a kutchuka kwa mankhwalawa pakati pa kuchepetsa thupi.

Pakati pazabwino za mankhwalawa, ndikofunikira kuwonetsa:

• kubwezeretsa kagayidwe ka lipid,
• Kuchepetsa kuchepa kwa mafuta, ndipo, potero, kutembenuka kwamafuta amthupi lawo,
• Malangizo a kuchuluka kwa cholesterol yoyipa m'magazi ndi shuga,
• kuponderezana ndi chidwi cha chakudya chifukwa cha kuchepa kwa mankhwala a insulin.

Chofunikira pa mankhwalawa ndikuti imapondereza chizolowezi chofuna kudya maswiti.

Komabe, sikuti Glucophage amangogwiritsidwa ntchito kuchepetsa thupi. Makamaka, ma analogu ake amadziwika, omwe amakhalanso ndi chinthu chachikulu chogwira ntchito. Zina mwa izo ndi:

Tengani Glucophage molondola komanso mosamala.

Tazindikira kale kuti mankhwalawa sikuti ndizotheka, koma amangofunika kwa odwala matenda ashuga.Komabe, kodi ndizotheka kugwiritsa ntchito Glucofage pakuchepetsa thupi? Ndizotheka, koma chifukwa cha izi, malangizo apadera ogwiritsira ntchito ayenera kupangidwa.

Poyamba, mudzakumana ndi kufunika kosintha zakudya zanu, komanso zochita zanu za tsiku ndi tsiku. Ponena za kutsatira zakudya, pamenepa, mukafuna kumwa mankhwalawa, ndizovomerezeka ndipo ziyenera kukwaniritsa izi:

• kukana zinthu zomwe zimachulukitsa shuga m'magazi,
• zokometsera zokometsera kupatula
• kukanidwa kwa chakudya champhamvu kwambiri,
• Zakudya ziyenera kukhala ndi zakudya zamafuta ambiri.

M'malo ovomerezeka, chakudyacho chiyenera kukhala chamagulu ochepa ndi otsika-kalori ndipo chizikhala 1800 kcal, koma osachepera 1000 patsiku.

Iyenera kutsatiridwa mosamalitsa popanda kupatuka. Ngati mumaganiza kuti awa ndi ovuta kwambiri, ndiye kuti mukulakwitsa kwambiri. Kukana kwathunthu zakumwa zokhala ndi mowa ndi fodya kumafunikira. Kutenga glucophage kuti muchepetse thupi, ndizoletsedwa kumwa ngakhale mankhwala okhala ndi mowa.

Komabe, simuyenera kungotsatira malangizo ogwiritsira ntchito, komanso masewera olimbitsa thupi ayenera kuchuluka. Popeza kukhalabe ndi moyo wogwira ntchito kumangokulitsa njira zomwe zikukakamizidwa kuti muchepetse thupi.

Mapiritsi a Glucophage a 500, 850, ndi 1000 mg amagulitsidwa kuma pharmacies. Kuti muchepetse kunenepa, muyenera kumwa mankhwalawo mosagwirizana ndi 500 mg. Kutalika kwa maphunzirowa kuyambira masiku 18 mpaka 20, osatinso. Potere, ziyenera kumwedwa katatu patsiku musanadye.

Gawo ili ndilofunika kuti metroformin iwonetse mphamvu zake zowyaka m'mphamvu yonse.

Zotsatira zoyipa ndi contraindication

Chifukwa chake tafika yankho lofunikira komanso lofunikira kwambiri. Mankhwala monga Glucofage, kuchepetsa thupi, mutha kumwa, koma pokhapokha atakhala mapiritsi a 500 mg, ndipo atachepetsa thupi amangomwa monga momwe amafunikira malangizo omwe ali pamwambawa. Ngati sichingaphwanyidwe, ndiye kuti, mankhwalawo sangawononge thupi.

Poterepa, awa si mawu chabe. Glucophage, monga chida chachipatala chomwe chimagwiritsidwa ntchito pakuchepetsa thupi, mu muyezo wa 500 mg, pazochitika zonse zachipatala ndi zasayansi, sanawonetse zotsatira zoyipa. Komabe, kafukufukuyu sangasonyeze kuti ngati mumwa mankhwalawa kuti muchotse kulemera kwakukulu, sikungayambitse mavuto. Kalanga, Glucophage, ngakhale pa mlingo wa 500 mg, ali ndi zotsutsana.

Chifukwa chake, tiyeni tiwone pamene simungathe kumwa mapiritsi awa kuti muchepetse thupi:

• ndi matenda a shuga 1
• pa mkaka wa pakati kapena pakati,
• munthawi zowawa kapena /
• ndi matenda a mtima
• ndi chidakwa,
• vuto la impso kapena mtundu wina wa matenda a impso.

Nthawi zambiri, mapiritsi a glucophage mu mlingo wa 500 mg wa kuchepetsa thupi amatha kumwa ndi aliyense. Komanso, tsopano mukudziwa malangizo ogwiritsa ntchito ndipo mankhwalawa siowopsa kutenga. Komabe, mulimonsemo, kuchepa thupi kuyenera kudziwa zovuta zomwe zingatsatire.

Dziwani kuti zizindikiritso zoyipa ndizofanana kwambiri ndi zomwe zimawonetsa poizoni.

Chifukwa chake, ngati mumamwa mapiritsi a Glucofage chifukwa cha kuchepa thupi, ndiye kuti mutha kukumana ndi:

• mutu
• kusanza
• nseru
• malungo
• kufooka koopsa
• kukulira m'mimba
• kupanga gasi bwino,
• matumbo colic.

Pakuchepetsa thupi kuthandizira kulemera kwamankhwala, mavuto onse omwe afotokozedwa pamwambapa amatha kuphatikizidwa, ngati sichoncho ndi mankhwala osokoneza bongo, ndiye ndi zakudya zopanda pake, zomwe zimakhala ndi chakudya chochuluka.

Zikatero, ndikofunikira kuti muchepetse mlingo wa mankhwalawo.Ngati zizindikirazo sizikusowa, muyenera kupeza chithandizo chamankhwala mwachangu.

Tikukulimbikitsani kuti muyang'ane mwachidule owotcha mafuta, kuphatikiza Metformin.

Ndipo osapereka zotsatira zoyenera.

Chakudya cholowa m'thupi chimabweretsa shuga. Amayankha mwa kuphatikiza insulin, ndikupangitsa kusintha kwa glucose kukhala maselo amafuta ndi mawonekedwe awo mu minofu. Mankhwala a antiidiabetesic Glucofage amatha kuwongolera, kusintha magazi a shuga.

Gawo lomwe limagwiritsa ntchito mankhwalawa ndi metformin, limachepetsa kusefukira ndikupanga matenda a lipid metabolism:

• oxidizing mafuta zidulo
• kukulitsa chidwi cha receptors ku insulin,
• kuletsa kaphatikizidwe ka shuga m'chiwindi ndikuwongolera kulowa kwake minofu yamitsempha,
• yambitsa njira yowonongera maselo amafuta, kutsitsa cholesterol.

Kugwiritsa ntchito glucophage kuphatikiza kumapereka zotsatira zabwino zoonda. Ngati simutsatira zoletsedwa za carb zazikulu, zotsatira za kuchepa thupi zimakhala zofatsa kapena ayi.

Mukamagwiritsa ntchito mankhwalawa pokhapokha kuchepa thupi, imagwiritsidwa ntchito pakadutsa masiku 18 mpaka 22, ndipo ndikofunikira kutenga nthawi yayitali kwa miyezi 2-3 ndikubwereza maphunzirowo. Mankhwala amatengedwa ndi zakudya - katatu patsiku, kumwa kwambiri.

Ubwino ndi kuipa

Kutenga Glucophage kumachenjeza pamene kumachepetsa zizindikiro. Sichikukhudza kuchuluka kwa insulini yomwe imapangidwa ndipo sikubweretsa zotsatira za hypoglycemic mwa odwala athanzi.

Glucophage 1000 mapiritsi

Malinga ndi kafukufuku wazachipatala, kugwiritsa ntchito mankhwalawa kwa prophylactic kumalepheretsa kukula kwa matenda ashuga a 2.

Zotsatira za kutenga Glucofage zitha kuwonetsedwa ndi:

• Matumbo . Monga lamulo, zizindikiro zam'mbali zimawonekera m'magawo oyamba a makonzedwe ndikupita pang'ono pang'ono. Yofotokozedwera ndi nseru kapena kutsegula m'mimba, kusadya bwino. Kulekerera kwa mankhwalawa kumakhala bwino ngati mlingo wake ukuwonjezeka pang'onopang'ono,
• dongosolo lamanjenje , yowonetsedwa ngati kuphwanya kukoma,
• bile ducts ndi . Amawonetsedwa ndi kukomoka kwa ziwalo, hepatitis. Ndi kutha kwa mankhwalawo, zizindikirizo zimazimiririka.
• kagayidwe - kuchepa kwa mayamwidwe a vitamini B12, chitukuko,
• khungu mawonekedwe . Itha kuwoneka pakhungu ndi zotupa, kuyabwa, kapena ngati erythema.

Mankhwala osokoneza bongo amatsogolera pakupanga lactic acidosis. Chithandizo chidzafunika kuchipatala mwachangu, maphunziro kuti akhazikitse mulingo wa lactate m'magazi, ndi chithandizo chamankhwala.

Cholepheretsa kutenga Glucophage ndiko kukhalapo kwa wodwala:

amodzi mwa mitundu ya kusakwanira -, chiwindi, - QC Kutenga?

Glucophage imapangidwira kukonzekera pakamwa kwamasiku onse ndi akulu ndi ana. Mlingo wa tsiku ndi tsiku umatsimikiziridwa ndi dokotala.

Glucophage nthawi zambiri amalembera achikulire omwe ali ndi kuchuluka kwa 500 kapena 850 mg, piritsi limodzi kawiri kapena katatu patsiku panthawi yakudya kapena pambuyo pake.

Ngati mukufuna kutenga Mlingo wapamwamba, tikulimbikitsidwa kuti musinthe pang'ono pang'onopang'ono kupita ku Glucofage 1000.

Njira yothandizira tsiku ndi tsiku ya Glucofage, mosasamala kanthu za kuchuluka kwa mankhwalawa - 500, 850 kapena 1000, omwe amagawidwa pawiri Mlingo masana, ndi 2000 mg, malire ndi 3000 mg.

Kwa anthu achikulire, Mlingo umasankhidwa payekha, poganizira momwe impso zimafunikira, kawiri pachaka, kuchititsa maphunziro paine. Glucophage imagwiritsidwa ntchito mu mono-komanso mankhwala ophatikiza, amatha kuphatikizidwa ndi mankhwala ena a hypoglycemic.

Kuphatikiza, mawonekedwe a 500 kapena 850 mg nthawi zambiri amalembedwa, omwe amatengedwa mpaka katatu patsiku, mlingo woyenera wa insulin amawerengedwa payekha, kutengera kuwerengera kwa glucose.

Kwa ana osaposa zaka 10, mankhwalawa amamuika ngati 500 kapena 850 mg, 1 piritsi 1 nthawi patsiku ngati monotherapy kapena insulin.

Pambuyo pakudya kwa milungu iwiri, mlingo woyenera umatha kusintha poganizira kuchuluka kwa shuga m'magazi. Mlingo woyenera kwambiri wa ana ndi 2000 mg / tsiku.Amagawidwa pawiri Mlingo wambiri kuti musayambitse kukhumudwa.

Glucophage Long, mosiyana ndi mitundu ina yamtunduwu, imagwiritsidwa ntchito mosiyana pang'ono. Amatengedwa usiku, ndichifukwa chake shuga m'mawa nthawi zonse amakhala wabwinobwino. Chifukwa chakuchedwa, sioyenera kudya kawirikawiri tsiku lililonse. Ngati pakuyikidwa kwa masabata 1-2 kufunika komwe sikukwaniritsidwa, ndikulimbikitsidwa kusinthana ndi glucophage yanthawi zonse.

Kunyumba »Kubala mwana» Momwe glucophage imagwirira ntchito pofuna kuchepetsa thupi. Ubwino ndi kuvulaza kwa mapiritsi a Glucophage: zoyipa, mawonekedwe ndi contraindication

Momwe mungadziwire komanso zomwe muyenera kuchita?

Ngakhale mankhwalawa amaperekedwa mosamalitsa malinga ndi zomwe wapangidwira, anthu ena (chifukwa cha opanga mankhwala osavomerezeka) amatha kugula popanda mankhwala. Zikatero, regimen imakokedwa ndi wodwalayo ndipo, monga lamulo, sizikugwirizana ndi zosowa kapena kuthekera kwa thupi. Zotsatira zamachitidwe oterewa nthawi zambiri zimakhala mankhwala osokoneza bongo, omwe amakhala ndi zotsatirazi:

• kusowa kwamadzi (kusowa kwamadzi),
• mseru, kusanza ndi kutsegula m'mimba,
• kupumira msanga, kutentha thupi, matenda obvutika,
• maonekedwe a ululu m'mimba ndi minofu.

Mukapanda kuchita zinthu zofunikira, kuchepa kwa thupi kumayambitsa ngozi ya lactic acidosis, hyperlactacidemic coma, hypoglycemia (osowa kwambiri), ngakhale kufa. Zingothandiza pamenepa:

• kukana kwathunthu kwa Glucophage panthawi yowonetsera zizindikiritso zoyambirira za kuwonongeka kwa moyo wabwino,
• kuchipatala mwachangu ndikuwonetsetsa magazi ake ali lactate,
• hemodialysis ndi symptomatic mankhwala.

Simuyenera kuchita kuyembekezera kuti malangizo ogwiritsira ntchito angakuthandizeni kupanga maphunzirowa. Komabe, adapangira anthu omwe akulimbana ndi matendawa, osati mapaundi owonjezera ndi masentimita.

Kodi pali zotsatira?

Chinthu chachikulu chomwe chimakondweretsa wodwala aliyense, ndizotsatira zomaliza. Kuti muone kuyipa kwa mankhwalawa, mutha kuyang'ana ku mabwalo azachipatala ndi malo omwe anthu omwe amamwa kale amagawana zomwe akumana nazo. Kuziwerenga, zikuwonekeratu kuti mankhwalawa azitha kukhala othandizira odwala matenda ashuga komanso anthu omwe kunenepa kwambiri kuposa koyambirira, ndipo BMI yafika pa 30 kg / m² kapena kupitirira apo.

Iwo omwe akufuna kugwiritsa ntchito "mapiritsi a zozizwitsawa" kuti athandize kuwonda (mwachitsanzo, kudzipanga dongosolo lisanafike nthawi yamakampani) ayenera kusiya ntchito zawo, chifukwa pamodzi ndi kulemera kwawo amatha kutaya gawo lalikulu laumoyo wawo.

Kodi Glucophage ingaperekedwe kwa ana?

Ngati ndemanga za ogwiritsa ntchito zimakopedwa komanso kukondera, ziwerengero zamankhwala zimangotengera zotsatira za zoyesa zosiyanasiyana komanso mayeso amapereka chidziwitso chomveka bwino pafunso lomwe layankhidwa. Chifukwa chake, makamaka, asayansi ochokera ku Yunivesite ya Oregon adayesa mayeso azachipatala mu 2014, momwe adawunikira momwe kuli koyenera kugwiritsa ntchito Glucofage ndi mankhwala ena angapo a metformin pochiza kunenepa kwambiri kwa ana ndi achinyamata.

Mayesowo anachitika miyezi isanu ndi umodzi. Pafupifupi odwala pafupifupi chikwi azaka zapakati pa 10 mpaka 16 okhala ndi cholozera chachikulu cha 26 mpaka 41 kg / m² ndipo osadwala matenda ashuga adatenga nawo mbali. Nthawi yomweyo, kulolera kwa glucose kunali mkati mwa malire oyenera kwa maphunziro onse.

Zotsatira zakuwonetsa kuti kwa ana, mankhwalawa siothandiza kwenikweni. Kugwiritsa ntchito limodzi ndi ntchito zolimbitsa thupi komanso chithandizo chamankhwala sizinali zothandiza kwenikweni kuposa kugwiritsa ntchito njira izi zokha. Zotsatira zabwino zinali kuchepa kwa BMI yamayuniti 1.38, omwe mawu akuti siopitilira 5%.

Kuti mupeze mankhwala omwe ali ndi mndandanda wazotsatira zoyipa, chizindikiro choterocho sichikukhumudwitsa chabe. Ndipo izi zikutanthauza kuti ndibwino kuti musazigwiritse ntchito pakuchepetsa thupi kwa achinyamata achinyamata omwe ali ndi vuto la kunenepa kwambiri koma alibe matenda a shuga.

Zochita Zamankhwala

Mlingo woyenera uli kutali ndi chokhacho chokhacho chomwe chimakhudza kugwira ntchito kwa Glucophage. Ngati muphatikiza kumwa ndi mankhwala ena, zotsatira zake nthawi zambiri zimakhala zosayembekezeka.

1. Kugwiritsa ntchito limodzi ndi mowa komanso mankhwala osokoneza bongo pazambiri zimatha kulephera. Wodwala amapeza woyamba hypoglycemia, kenako amagwa ndi hypoglycemic coma ndipo (pakalibe chithandizo chadzidzidzi) amwalira.
2. Ngati pa nthawi yomwe mumamwa mankhwalawo simumadziletsa pakudya zakudya zamagulu a shuga (mwachitsanzo, shuga kapena maswiti), kuyesa kwanu kuonda kudzakhala ngati kumenyanirana ndi magesi.
3. Ma ayodini okhala ndi ayodini omwe ali ndi radiopaque nawonso sagwirizana. Chifukwa chake, ngati simukufuna kupeza lactic acidosis, muyenera kukana kumwa mankhwalawa masiku 2 asanafike maphunziro a radiology ndi x-ray. Maphunzirowa ayeneranso kuyambitsidwanso pasanathe maola 48 (bola ngati pakuwunika sikunawonekere zozunzika mkati mwa ziwalo zamkati).
4. Zakudya zophatikiza pamodzi ndi kumwa mankhwalawa zimawopseza kuti zingayambitse kusokonezeka kwamphamvu mkati mwa ziwalo zamkati. Panthawi yamankhwala (kuchepa thupi) - thupi liyenera kulandira mchere ndi mavitamini onse ofunikira.

Kuphatikiza kumene kumafunikira kuchenjeza:

1. Ngati mukufuna kuphatikiza kugwiritsa ntchito mankhwalawa ndi ma diuretics ndi mankhwala osokoneza bongo mwachindunji, khalani okonzekera kuti mudzayang'anitsitsa kuchuluka kwa shuga m'magazi mosamala kwambiri komanso nthawi zambiri.
2. Kuphatikizika "Glucophage + loop diuretics" motsutsana ndi kumbuyo kwaimpso kapena kugwira ntchito kwa chiwindi kulephera kukuwopseza kukhala lactic acidosis.
3. Poyesa kuphatikiza ndi insulin, ma salicylates ndi mankhwala a sulfonylurea, wodwalayo wapezeka kale ndi hypoglycemia.
4. Mankhwala a Cationic ndi antihypertensive angapangitse kusintha kwakukulu kwa mankhwala ndi momwe amagwiritsidwira ntchito.
5. Nifedipine, chlorpromazine, ndi zingapo za beta 2 - adrenomimetics zimachulukitsa kuchuluka kwa shuga m'magazi, chifukwa chake, pamlingo wambiri, amatha kusintha momwe mankhwalawa amathandizira kutsika kwake ndikuyambitsa kupatsidwa insulin.
6. Simuyenera kutenga Glucophage palimodzi, osakambilana kaye ndi dokotala. Ngakhale mankhwalawa ali ndi mfundo zofananira, zotsatira zake kuphatikiza kwawo zimatha kukhala kuwombera kawiri mkati mwa thupi.

Msika wa mankhwalawa ukupita patsogolo kwambiri komanso mwachangu chaka chilichonse. Chifukwa chake, ngati simunapeze mankhwala ena omwe mukutenga pamndandandawu, izi sizitanthauza kuti kugwiritsa ntchito kwawo molumikizana ndi Glucofage sikungakhale ndi zotsatirapo zoyipa. Kuteteza thupi lanu ku ngozi zosafunikira, zonse zimatheka kokha mwa kulumikizana ndi dokotala. Chifukwa chake simudzasokoneza mlingo, ndipo muphunzira za zovuta zamtundu wovuta, zodziwika kokha kwa katswiri wodziwa.

Kupanga ndi mawonekedwe a kumasulidwa

Glucophage ndi wozungulira, piritsi la biconvex loyera, utoto wamafuta, wopangidwira pakamwa. Mankhwala omwe ananyamula pamatumbo a 10 kapena 20 ma PC. Phukusi la makatoni 1 lili ndi mapiritsi 30 kapena 60, malangizo ogwiritsira ntchito. Wopanga amapereka 3 Mlingo wa Glucofage ndi zomwe zili pompo - 500, 850 ndi 1,000 mg patebulo limodzi. Zomwe zimapangidwira mankhwala:

Kusintha kofunikira pakudya

Zakudya mutatenga Glucofage imafunika. Komanso, muyenera kutsatira izi ngakhale mutamaliza maphunziro a mankhwalawa.Chilimbikitso chokhacho kwa iwo omwe amakonda chakudya chamtengo wapatali ndi chofunda kuposa kusala kapena kudya chakudya.

Mutha kusankha mndandanda woyenera komanso wopanda malire. Poyamba, thupi lidzalandira zonse zofunikira kuchokera ku chakudya, pomwe kuchuluka kwa zopatsa mphamvu kumachepa. Njira yachiwiri imayang'ana pa zakudya zomwe zimakhala ndi chakudya chamagulu ambiri, koma zimachotsa kwathunthu lipids kuzakudya.

M'magawo onse awiriwo, menyu anu ayenera kuphatikizanso zakudya zomwe zimakhala ndi masamba ambiri (nyemba, mbewu, nandolo). Koma zokhudzana ndi shuga ndi zinthu zomwe zili ndi shuga ziyenera kuyiwaliratu.

Glucophage ndi amodzi mwa mankhwala amphamvu ndipo ali ndi mndandanda waukulu wa zotsutsana ndi zotsatira zoyipa. Chifukwa chake, kumwa iwo ngati njira yochepetsera kunenepa sikuyenera kwa anthu athanzi (omwe alibe zina zina kuposa kukhala onenepa kwambiri). Zotsatira zake zimakhala zakanthawi kochepa, koma zotsatira zake zimakhala zovuta.

Ngati mukufunabe kuchepetsa kulemera pamapiritsi, funsani dokotala wanu ndikuwapempha kuti akulemberereni mitundu kapena alangize othandizira pazakudya zanu. Ndipo siyani mankhwalawa kwa iwo omwe amafunikira.

Kuti mumve mankhwala ena omwe amathandizira kuchepetsa thupi:

Glucophage ndi Glucophage Long: phunzirani zonse zomwe mukufuna. Kumvetsetsa momwe amwe mapiritsi amtundu wa shuga wachiwiri komanso kuwonda. Amagwiritsidwanso ntchito (monga panobe mosavomerezeka) kuti achepetse ukalamba ndi kupewa matenda okhudzana ndi zaka, makamaka omwe ali ndi kunenepa kwambiri. Patsamba ili mupezako olembedwa mchilankhulo chomveka. Phunzirani kuwonetsa, contraindication, Mlingo ndi zoyipa. Ndemanga zambiri za odwala zimaperekedwanso.

Werengani mayankho a mafunso:

Glucophage ndi Glucophage Long: Nkhani zatsatanetsatane

Mvetsetsani kusiyana pakati pa Glucofage Long ndi mapiritsi wamba. Yerekezerani ndemanga za odwala za mankhwalawa ndi anzawo aku Russia otsika mtengo.

Malangizo ogwiritsira ntchito

Kutenga Glucophage (metformin), muyenera kutsatira zakudya.

Pansipa pali mayankho a mafunso omwe odwala matenda ashuga nthawi zambiri amafunsa okhudza mankhwalawa.

Kodi pali kusiyana kotani pakati pa glucophage ndi metformin?

Glucophage ndilo dzina lamalonda lamankhwala, ndi zomwe zimagwira. Glucophage si mtundu wokhawo wapiritsi womwe umagwira ndi metformin. Pamankhwala mutha kugula mankhwalawa a matenda a shuga komanso kuti muchepetse kunenepa pansi pa mayina osiyanasiyana. Mwachitsanzo, Siofor, Glformin, Diaformin, etc. Komabe, Glucofage ndi mankhwala ochokera kunja omwe amagulitsidwa kunja. Siotsika mtengo kwambiri, koma amaonedwa kuti ndi wapamwamba kwambiri. Mankhwalawa ali ndi mtengo wotsika mtengo kwambiri, ngakhale kwa nzika zapamwamba, chifukwa tsambalo silikulimbikitsa kuyesa anzawo otsika mtengo.

Kodi pali kusiyana kotani pakati pa glucophage nthawi zonse ndi glucophage yayitali? Ndi mankhwala ati omwe ali bwino?

Glucophage Long - ichi ndi piritsi lomwe limamasulidwa pang'onopang'ono pazomwe zimagwira. Amayamba kuchita mochedwerapo kuposa Glucophage yokhazikika, koma zotulukapo zawo zimakhala motalikitsa. Izi sizikutanthauza kuti mankhwala ena ndi abwino kuposa enawo. Amapangidwira zolinga zosiyanasiyana. Mankhwala otulutsidwa nthawi zambiri amatengedwa usiku kuti m'mawa wotsatira pakhale shuga wamba wamagazi.Komabe, mankhwalawa ndi oyipa kuposa glucofage wokhazikika, oyenera kuwongolera shuga tsiku lonse. Anthu omwe mapiritsi a metformin okhazikika amayambitsa matenda otsegula m'mimba amalangizidwa kuti ayambe kumwa mankhwalawa osathamanga kuti awonjezere. Ngati izi sizikuthandizani, ndiye kuti muyenera kusinthira ku kudya kwa tsiku ndi tsiku kwa mankhwala Glucofage Long.

Kodi ndiyenera kudya zakudya ziti mukamamwa mankhwalawa?

Ili ndiye njira yoyenera yothetsera odwala omwe ali ndi kunenepa kwambiri, prediabetes ndi matenda a shuga 2. Afufuzeni ndikuwachotseratu pachakudya chanu. Idyani zabwino komanso zathanzi, zomwe mungagwiritse ntchito. Zakudya zama carb ochepa ndizo chithandizo chachikulu cha matenda ashuga amtundu wa 2. Iyenera kuthandizidwa ndikugwiritsa ntchito mankhwalawa Glucophage, ndipo, ngati pakufunika,, jekeseni wa insulini wochepa. Kwa anthu ena, zakudya zamafuta ochepa zimakuthandizani kuti muchepetse thupi, pomwe ena, sichoncho. Komabe, iyi ndi chida chabwino kwambiri chomwe tili nacho. Zotsatira za kudya kwamafuta ochepa, zamafuta ochepa kwambiri ndi zoyipa kwambiri. Mwa kusinthira ku chakudya chamafuta ochepa, muthanso shuga wanu wamagazi, ngakhale ngati simungathe kuchepetsa thupi kwambiri.

Werengani mwatsatanetsatane zamalonda:

Kodi glucophage imachulukitsa kapena kuchepetsa magazi?

Glucophage sikuchulukitsa magazi. Zimawonjezera pang'ono zotsatira zamapiritsi oopsa - okodzetsa, beta-blockers, ACE inhibitors ndi ena.

Kwa odwala matenda ashuga omwe amathandizidwa molingana ndi njira zamasamba, kuthamanga kwa magazi kumatsikira mwachangu. Chifukwa zimachita monga choncho. Amachotsa madzimadzi owonjezera kuchokera mthupi, amachotsa edema ndikuwonjezera nkhawa pamitsempha yamagazi. Glucophage ndi mankhwala osokoneza bongo oonjezera amathandizira pang'ono zomwe zimachitika wina ndi mnzake. Ndi kuthekera kwakukulu, mudzafunika kusiyiratu mankhwala omwe amachepetsa kuthamanga kwa magazi. Izi sizokhumudwitsa :).

Kodi mankhwalawa amagwirizana ndi mowa?

Glucophage imagwirizana ndi kumwa moyenera. Kumwa mankhwalawa sikutanthauza kukhala ndi moyo wopanda nkhawa. Ngati palibe zotsutsana pakutenga metformin, ndiye kuti simukuletsedwa kumwa pang'ono. Werengani nkhaniyo "", ili ndi zambiri zothandiza. Mwawerengera pamwambapa kuti metformin ili ndi zowopsa koma zosowa kwambiri - lactic acidosis. Nthawi zambiri, mwayi wokhala ndi vutoli ndi pafupifupi zero. Koma imakwera ndi kuledzera kwambiri. Chifukwa chake, potengera maziko akumatenga metformin sayenera kuledzera. Anthu omwe sangakhale odziletsa ayenera kupewa mowa.

Zoyenera kuchita ngati glucophage sichithandiza? Ndi mankhwala ati omwe ali ndi mphamvu?

Ngati Glucophage atatha kudya masabata ochepa a 6-8 osathandiza kuti muchepetse makilogalamu angapo onenepa kwambiri, tengani mayeso a magazi a mahomoni a chithokomiro, kenako mukaonane ndi endocrinologist. Ngati hypothyroidism (kusowa kwa mahomoni a chithokomiro) akapezeka, muyenera kuthandizidwa ndi mapiritsi a mahomoni omwe dokotala wanu wakupatsani.

Mwa odwala ena omwe ali ndi matenda a shuga a 2, glucophage samachepetsa shuga ya magazi konse. Izi zikutanthauza kuti kapamba watha, kupanganso insulin yake kwatha, matendawa akusintha ngati matenda ashuga akulu amodzi. Mosakhalitsa muyenera kuyamba kubaya insulin. Amadziwikanso kuti mapiritsi a metformin sangathe kuthandiza odwala matenda ashuga. Odwala otere amafunika mwachangu, osasamala mankhwalawo.

Kumbukirani kuti cholinga chamankhwala othandizira odwala matenda ashuga ndi kusunga shuga nthawi zonse mkati mwa 4.0-5,5 mmol / L. Ambiri mwa odwala matenda ashuga, Glucophage amatsitsa shuga, koma osakwanira kuti abwezeretse mwakale. Ndikofunikira kudziwa kuti ndi nthawi yanji ya kapamba yomwe singathe kuthana ndi katundu, ndikuthandizira ndi jakisoni wa insulini yochepa. Musakhale aulesi kugwiritsa ntchito insulin kuwonjezera pa kumwa mankhwala ndi kudya. Kupanda kutero, zovuta za shuga zidzachitika, ngakhale ndi shuga za 6.0-7.0 ndi apamwamba.

Ndemanga ya anthu omwe amamwa Glucofage kuti achepetse thupi komanso chithandizo chamankhwala a shuga 2 amatsimikizira kuti mapiritsiwa ndi othandizira. Amathandizira bwino kuposa mitengo yamtengo wapatali yopanga Russian. Zotsatira zabwino zimapezeka ndi odwala omwe amayang'ana kumbuyo kwa mapiritsi. Odwala omwe ali ndi matenda a shuga a mtundu wachiwiri amatha kuchepetsa shuga kuti akhale bwino monga momwe amakhalira anthu athanzi. Ambiri m'mawunikidwe awo amadzitamandanso kuti amatha kutaya makilogalamu 15 mpaka 20 owonjezera. Ngakhale chitsimikizo cha kuchepetsa kulemera sichingaperekedwe pasadakhale. Tsamba limatsimikizira odwala matenda ashuga kuti azitha kuyang'anira matenda awo, ngakhale zitakhala kuti sizikuyenda bwino amachepetsa thupi.

Anthu ena amakhumudwitsidwa kuti Glucophage sikuti imayambitsa kuwonda msanga. Zowonadi zake, momwe zimakhalira pakuwonekera zimawonekera pasanathe milungu iwiri, makamaka mukayamba kulandira chithandizo chochepa. Mukamachepetsa thupi, mumakhala ndi mwayi wokulirapo zotsatira zazitali. Mankhwala Glucophage Long ndiwocheperako kuposa mankhwala ena onse a metformin kuyambitsa matenda am'mimba komanso zotsatira zina zoyipa. Kwa anthu omwe akufuna kuchepa thupi, zimathandiza kwambiri. Koma mankhwalawa siabwino kwenikweni kuwongolera shuga m'magazi odwala matenda ashuga pambuyo kudya masana.

Ndemanga zoyipa zam'mapiritsi a Glucofage amasiyidwa ndi odwala omwe ali ndi matenda amtundu wa 2 omwe sakudziwa zakudya zamafuta ochepa kapena safuna kusintha. , wadzaza ndi chakudya chamafuta, umawonjezera shuga m'magazi ndikukhala bwino. Kukonzekera kwa Metformin ngakhale jakisoni wa insulin sangabwezele zolakwika zawo. Mwa odwala matenda ashuga omwe amatsatira zakudya zamagulu ochepa zopatsa mphamvu, zotsatira za chithandizo chake sizabwino. Siyenera kulingaliridwa kuti izi zimachitika chifukwa cha kufooka kwa mankhwalawa.

Chipatso cha Matenda A shuga

Ndemanga 53 pa "Glucophage ndi Glucophage Long"

1. Julia
   
2. Yuri Stepanovich
   
3. Oksana
   
4. Natalya
   
5. Rimma
   
6. GALINA
   
7. Irina
   
8. Natalya
   
9. Natalya
   
10. Irina
    
11. Svetlana
    
12. Victoria
    
13. Irina
    
14. Irina
    
15. Natalya

Mapiritsi ali ndi zomwe zimagwira - metformin hydrochloride500, 850, 1000 mg aliyense.

Zosakaniza zina: povidone ndi magnesium stearate.

Utoto wamafilimuwo umakhala ndi hypromellose, ndipo mapiritsi a 1000 mg amapezekanso ndi Opadry Kli, macrogol 400 ndi 8000.

Glucophage ndi insulin

Ngati mukufunikira insulin yowonjezera, yotsirizayo imagwiritsidwa ntchito kokha pa mlingo womwe adotolo adatenga.

Mankhwala othandizira omwe ali ndi metamorphine ndi insulin amafunika kuti akwaniritse kuchuluka kwa shuga m'magazi. Algorithm yokhazikika ndi piritsi ya 500 mg (nthawi zambiri imakhala 850 mg) kawiri kapena katatu patsiku.

Mlingo wa ana ndi achinyamata

Kuyambira azaka khumi ndi akulu - ngati mankhwala odziyimira pawokha, kapena ngati gawo limodzi la mankhwala (pamodzi ndi insulin).

Mlingo woyenera (woyamba) wosakwatiwa tsiku lililonse ndi piritsi limodzi (500 kapena 850 mg.), Lomwe limatengedwa ndi zakudya. Amaloledwa kumwa mankhwalawa kwa theka la ola mutatha kudya.

Kutengera kuchuluka kwa shuga m'magazi, mlingo wa mankhwalawo umasinthidwa pang'onopang'ono (mizere - osachepera sabata imodzi kapena ziwiri). Mlingo wa ana waletsedwa kuchuluka (kupitirira 2000 mg). Mankhwalawa agawidwe m'magawo atatu, osachepera awiri.

Kuphatikiza komwe sikuloledwa mwanjira iliyonse

Othandizira kusiyanitsa ndi X-ray (yokhala ndi ayodini). Kuunika kwa radiology kumatha kukhala chothandizira pakukula kwa lactic acidosis kwa wodwala yemwe ali ndi matenda a shuga.

Glucophage amasiya kutengedwa masiku atatu kafukufukuyu asanatengere masiku atatu pambuyo pake (kwathunthu, sabata limodzi ndi tsiku la phunziroli). Ngati ntchito yaimpso malinga ndi zotsatira zake sizinakhutire, nthawi imeneyi imawonjezeka - mpaka thupi litabwezeretseka kwathunthu.

Chingakhale chanzeru kukana kugwiritsa ntchito mankhwalawa ngati pali kuchuluka kwa ethanol mthupi (kuledzera kwakumwa).Kuphatikiza uku kumayambitsa mapangidwe a machitidwe kuti awonetsere zizindikiro za lactic acidosis. Zakudya zama calorie otsika kapena vuto la kuperewera kwa zakudya m'thupi, makamaka motsutsana ndi maziko a kulephera kwa chiwindi, zimawonjezera ngoziyi.

Pomaliza Ngati wodwala amwa mankhwalawa, ayenera kusiyiratu kumwa mowa uliwonse, kuphatikizapo mankhwala omwe amaphatikizapo ethanol.

Kuphatikiza komwe kumafuna kusamala

Danazole Kugwiritsa ntchito nthawi yomweyo kwa Glucofage ndi Danazole sikofunikira. Danazole ndi wowopsa ndi hyperglycemic effect. Ngati ndizosatheka kukana pazifukwa zosiyanasiyana, kusintha kwapadera kwa Glucofage ndikuwunika pafupipafupi kuchuluka kwamagazi pamafunika.

Chlorpromazine mu mlingo waukulu wa tsiku ndi tsiku (woposa 100 mg), womwe umathandiza kuwonjezera kuchuluka kwa shuga m'magazi ndipo umachepetsa mwayi wokhala ndi insulini. Kusintha kwa mlingo kuyenera.

Ma antipsychotic. Chithandizo cha odwala omwe ali ndi antipsychotic chiyenera kuvomerezedwa ndi dokotala. Kusintha kwa mlingo wa Glucofage ndikofunikira malinga ndi kuchuluka kwa shuga m'magazi.

GCS (glucocorticosteroids) imasokoneza kulekerera kwa glucose - kuchuluka kwa glucose m'magazi kumakwera, komwe kungayambitse ketosis. Zikatero, Glucophage iyenera kumwedwa kutengera kuchuluka kwa shuga m'magazi.

Zochita kupukutira m'mimba pamene zimatengedwa nthawi yomweyo ndi glucophage zimabweretsa chiopsezo cha lactic acidosis. Ndi CC kuchokera pa 60 ml / mphindi ndi pansi, glucophage sinafotokozedwe.

Adrenomimetics. Mukamamwa ma Beta 2-adrenergic agonists, kuchuluka kwa shuga m'thupi kumawukanso, komwe nthawi zina kumafunanso Mlingo wa insulin wina wodwala.

Ma inhibitors a ACE ndi mankhwala onse a antihypertensive amafuna kusintha kwa mlingo wa metformin.

Sulfonylurea, insulin, acarbose ndi salicylates akaphatikizidwa pamodzi ndi glucophage angayambitse kukula kwa hypoglycemia.

Mimba komanso kuyamwa. Zinthu Zakutha

Glucophage sayenera kumwedwa panthawi yomwe ali ndi pakati.

Matenda akulu a shuga amatha kubadwa kwatsopano kwa mwana wosabadwayo. Pakapita nthawi - umunthu wangozi. Ngati mayi akufuna kubereka kapena ali m'magawo oyamba a kubereka, ndikofunikira kukana kumwa mankhwala Glucofage. M'malo mwake, chithandizo cha insulin chimayikidwa kuti chikhale ndi kuchuluka kwa shuga.

Kwa odwala. Chidziwitso Chofunikira cha Lacticosis

Lactic acidosis si matenda wamba. Komabe, njira zonse zofunikira ziyenera kuchitidwa kuti athetse chiwonetsero chake, popeza matenda amtunduwu amadziwika ndi zovuta zambiri komanso kufa kwakukulu.

Lactic acidosis nthawi zambiri imawonekera mu odwala omwe amatenga metamorphine omwe anali ndi vuto lalikulu laimpso chifukwa cha matenda a shuga.

Zina zomwe zimayambitsa ngozi ndi izi:

• Zizindikiro za matenda ashuga.
• Mawonekedwe a ketosis.
• Kutalika kwa vuto la kuperewera kwa thupi.
• Magawo owopsa a chidakwa.
• Zizindikiro za hypoxia.

Ndikofunikira. Ndikofunika kulabadira zizindikiro za gawo loyambirira la lactic acidosis. Ichi ndi chizindikiro cha kuwonekera, kuwonekera minofu kukokana, kukomoka, kupweteka kwam'mimba komanso asthenia yayikulu. Acidotic dyspnea ndi hypothermia, ngati zizindikiro isanachitike chikomokere, amasonyezanso matendawa. Zizindikiro zilizonse za metabolic acidosis ndizomwe zimapangitsa kuti mankhwalawo athe kaye komanso kufunafuna chithandizo chamankhwala mwachangu.

Mankhwala

Mankhwala Glucophage amasonyezedwa kwa odwala omwe samadalira insulin, pomwe kuchita masewera olimbitsa thupi komanso zakudya zapadera sizithandiza kutsika kwamisempha. Malangizowo akuti othandizira odwala matenda ashuga amatha kugwira ntchito ngati kunenepa kwambiri kumachitika. Pochita, zimaphatikizidwa ndi zonse insulin mankhwala ndi mitundu ingapo yochepetsera shuga.

Wopanga amatulutsa Glucophage antidiabetesic wothandizira mu mapiritsi a mitundu yosiyanasiyana: 500, 850 ndi 1000 mg. Chomwe chimagwiritsa ntchito mankhwalawa ndi metformin hydrochloride - woimira kalasi yayikulu. Piritsi lililonse la mankhwalawa limaphatikizapo zinthu monga povidone, macrogol (4000, 8000), hypromellose ndi magnesium stearate.

Mtundu wapadera wamasulidwa ndi mankhwala omwe akhala akuchita kwa nthawi yayitali. Mapiritsi amapangidwa mosiyanasiyana Mlingo (Glucofage Long 500 ndi Glucofage Long 750).

Glucophage siyikutsogolera kukula kwa hypoglycemia, ndipo palibenso kulumikizana kowongoka kuzidziwitso zamagulu a shuga. Mukamatenga Glucofage mwa anthu athanzi, palibe kuchepa kwa glycemia yomwe ili pansi pa malire a 3.3-5.5 mmol / L. Matenda a shuga amakwaniritsidwa chifukwa cha mankhwala otsatirawa:

1. Kupanga insulin kwa beta maselo a beta.
2. Kuchuluka kwa chiwopsezo cha "maselo chandamale" mapuloteni ndi adipose minofu ya insulin.
3. Kupititsa patsogolo kwa kukonza kwa dzuwa ndi minyewa.
4. Kuchepetsa chakudya cham'mimba mwa chimbudzi.
5. Kutsitsa kuchuluka kwa shuga chiwindi.
6. Kupititsa patsogolo kagayidwe.
7. Kuchepetsa kuzama kwa cholesterol, otsika ochepa lipoproteins ndi triglycerides.
8. Kuchepetsa thupi kwa odwala omwe ali ndi kunenepa kwambiri (Glucofage acidifying acid acid).

Pogwiritsidwa ntchito pakamwa pa Glucofage metformin, hydrochloride imalowa mwachangu m'matumbo am'mimba, ndipo mawonekedwe ake apamwamba amawonekera pambuyo pa maola awiri ndi theka. Glucophage Long, mmalo mwake, imamizidwa nthawi yayitali, chifukwa chake imangotengedwa kamodzi kokha pa tsiku.

Gawo logwira ntchito silikugwirizana ndi mapuloteni, omwe amafalikira mwachangu kuzinthu zonse zama cell a thupi. Metformin imakumbidwa limodzi ndi mkodzo.

Anthu omwe ali ndi vuto la impso ayenera kudziwa kufunikira kwa kuletsa kwa mankhwala mu minofu.

Pharmacodynamics ndi pharmacokinetics

Mapiritsi a Glucophage okhala ndi hypoglycemic yotchulidwa amathandizira chidwi cha insulin zolandirira, potero kusintha kukhathamira kwa glucose. Metformin, pokhala biguanide pakupanga mankhwala, amachepetsa gluconeogeneis m'maselo a chiwindi - hepatocytes, activate lipid metabolism, akuchedwa kuyamwa kwa chakudya cham'mimba, komanso amachepetsa kuchuluka kwa glycemia ndi glycated hemoglobin.

Chithandizo chogwira ntchito chimapangitsanso kapangidwe ka glycogen, pomwe sichikhudza kutulutsidwa kwa insulin ndi maselo a kanyumba kogulitsa matumba a kapamba. Chiwopsezo cha kukhala ndi hypoglycemia ndi chocheperako. Pogwiritsa ntchito nthawi yomweyo ndi chakudya, mayamwidwe a glucophage amachepetsa. Mndandanda wa bioavailability ndi 50-60%. Mankhwalawa amadzaza msanga m'mimba, amafika pamtunda wa plasma wambiri atatha maola 2,5. Metabolism imachitika m'chiwindi, theka la moyo ndi maola 6.5. Mankhwalawa amachotsa impso ndi mkodzo osasinthika.

Contraindication hypoglycemic mankhwala

Kafukufuku waposachedwa awonetsa kuti kumwa mankhwala ndikothandiza pakubala. Kuphatikiza apo, imatengedwa ndi polycystosis, yomwe idapangitsa kuti 57% ya zolephera kukhala ndi ana. Izi zitha kupezeka chifukwa cha metabolic syndrome kapena kukana insulin.

Poyamba, odwala ambiri amakhala ndi zizindikiro monga kuchedwa, kusakhazikika, komanso cystitis. Zizindikirozi sizikhala bwino ndipo zimafunikira kulumikizidwa mwachangu ndi dokotala wazamankhwala.

Kuphatikiza kwa Glucophage ndi Duphaston kumathandizira kukhazikika kwamadzi.

Mtengo, kuwunika ndi zofanana

Glucophage imadabwitsa osati ndi ntchito yake, komanso mitengo yosangalatsa. Chifukwa chake, mtengo wa 1 phukusi la Glyukofage umasiyana ndi ma ruble a 105 mpaka 310, ndikuchitapo kanthu kwa nthawi yayitali - kuchokera pa ma ruble 320 mpaka 720, kutengera mtundu wa kumasulidwa.

Ndi hyperglycemia, endocrinologists amakupatsani Glucofage 500 - malangizo ogwiritsira ntchito mankhwalawa amaphatikiza chidziwitso cha kudya kwake nthawi yomweyo ndi chakudya, kuti matenda a shuga akhale magazi. Katundu wa mankhwalawa kuti athane ndi mafuta adayambitsa kuti mankhwalawo adayamba kugwiritsidwa ntchito pakuchepetsa thupi. Onani zomwe zikuwoneka ngati zingatheke kuchepetsa thupi ndi mapiritsi awa, komanso momwe mungapangidwire kuchuluka kwa shuga m'magawo 2 a shuga.

Mapiritsi a Glucophage

Malinga ndi gulu la pharmacological, mankhwala a Glucofage ndi a gulu la othandizira pakamwa omwe amachepetsa shuga ya magazi mwa odwala omwe ali ndi matenda a shuga. Mankhwalawa ali ndi kulekerera kwabwino m'matumbo, chinthu chomwe chimapangidwira ndikupangidwa ndi metformin hydrochloride, yomwe ndi gawo la gulu la Biguanides (zomwe zimachokera).

Glucophage Long 500 kapena Glucophage 500 - awa ndiwo mitundu yayikulu yotulutsira mankhwala. Loyamba limadziwika ndi kuchitapo kanthu kwanthawi yayitali. Mapiritsi ena okhala ndi mitundu yosiyanasiyana ya metformin hydrochloride nawonso amakhala pawokha. Makonda awo:

The ndende ya yogwira thunthu, mg 1 pa pc.

500, 850 kapena 1000

Choyera, chozungulira (chozungulira cha 1000, cholemba)

Povidone, hypromellose, magnesium stearate, koyera opadra (hypromellose, macrogol)

Carlone sodium, magnesium stearate, hypromellose

10, 15 kapena 20 zidutswa pachimake

30 kapena 60 ma PC. mu paketi

Mankhwala a Glucophage a shuga

Mankhwalawa amathandizira chidwi cha zolandilira kuti apange insulin komanso imathandizira kukonzanso shuga m'mitsempha, zomwe zimapangitsa kutsika kwa shuga m'magazi. Izi zimathandiza kupewa hyperglycemia, yomwe itha kutsagana ndi matenda amtundu wa 2 shuga. A single (kwa Glucofage Long) kapena kawiri mlingo wa mankhwalawo amathandizira wodwala matenda ashuga.

Glucofage 500 yakuonda

Kuphatikiza popanga shuga m'magazi, Glucofage imagwiritsidwa ntchito pakuchepetsa thupi. Malinga ndi madotolo, ndikosayenera kumwa mapiritsi a anthu athanzi, chifukwa nthawi zambiri pamakhala kuwonetsa kosiyanasiyana. Mankhwala amachepetsa cholesterol yoyipa ndipo amatulutsa matenda a metabolism mwa odwala matenda ashuga okha. Ena samvera zonena za madokotala ndipo amamwa mapiritsi azakudya. Poterepa, kufunsira ndikutsatira malangizowo ndikufunika:

• kumwa mlingo wa 500 mg musanadye katatu patsiku, mlingo waukulu wa metformin tsiku lililonse ndi 3000 mg,
• Ngati mulingo wambiri (chizungulire ndi mseru zimayang'aniridwa), muchepetse ndi theka.
• Maphunzirowa atenga masiku 18-22, mutha kubwereza mlingo pambuyo miyezi ingapo.

Momwe mungatenge Glucophage

Malinga ndi malangizo ogwiritsira ntchito, mankhwalawa Glucophage amatengedwa pakamwa. Kwa achikulire, mlingo woyambirira wa monotherapy ndi 500 mg kapena 850 mg 2-3 kawiri pa tsiku mukatha kudya kapena nthawi yomweyo. Mlingo wokonza ndi 1500-2000 mg patsiku, womwe umagawidwa pazigawo zitatu, ndipo kuchuluka kwa tsiku lililonse ndi 3000 mg. Akaphatikizidwa ndi insulin, mlingo woyambirira ndi 500-850 mg 2-3 kawiri pa tsiku.

Kwa ana opitilira zaka zopitilira 10, mlingo woyambirira ndi 500-850 mg kamodzi patsiku pambuyo chakudya kapena pakudya. Pambuyo masiku 10-15, mlingo umasinthidwa, pazofika tsiku lililonse ndi 2000 mg mumagawo awiri. Mwa anthu achikulire, chifukwa cha kuchepa kwa ntchito ya impso, mlingo umatsimikiziridwa kutengera zomwe zili serum creatinine. Mankhwala Glucofage Akuluakulu opitirira 18 amatenga kamodzi patsiku chakudya chamadzulo, mlingo woyambirira ndi piritsi 1, pambuyo masiku 10-15 amasinthidwa kukhala 1.5 g (mapiritsi 2) kamodzi / tsiku. Ngati izi sizokwanira, mpesa wokwanira ukhale 2.25 g (mapiritsi atatu) kamodzi patsiku.

Malangizo apadera

Mu malangizo ogwiritsira ntchito, pali gawo la malangizo apadera omwe ayenera kuphunziridwa mosamala:

• chifukwa cha kukokomeza kwa metformin, nthenda yachilendo koma yowopsa yokhala ndi vuto lalikulu lactic acidosis imatha kuchitika (kulephera kwa impso, ketosis, kufa ndi njala, chakudya chamagulu owonjezera, uchidakwa ndi omwe angayambitse)
• kumwa mankhwalawa kuyenera kuyimitsidwa masiku awiri asanachitike opareshoni,
• Ndi monotherapy, mankhwalawa sangathe kuyambitsa hypoglycemia,
• mankhwalawa sasokoneza kukhudzidwa kwa chidwi ndi kuthamanga kwa zochitika zama psychomotor, chifukwa chake, zitha kutengedwa pakuwongolera njira.

Glucophage pa nthawi yapakati

Kugwiritsa ntchito mankhwalawa kumayesedwa panthawi yomwe muli ndi pakati, koma, malinga ndi ndemanga zochepa za amayi apakati, komabe amakakamizidwa kuti amwe, palibe chitukuko cha zolakwika zatsopano mwa akhanda. Mukakonzekera kutenga pakati kapena pakachitika, chithandizo chamankhwala chikuyenera kutha, insulini iyenera kukhazikitsidwa. Metformin amamuchotsa mkaka wa m'mawere;

Kuyanjana kwa mankhwala osokoneza bongo

Malangizo ogwiritsira ntchito Glucofage akuwonetsa kuyanjana kwake ndi mankhwala ena:

• ndizoletsedwa kuphatikiza mankhwalawa ndi ayodini okhala ndi radiopaque kuti asayambitse lactic acidosis ndi zovuta za matenda ashuga,
• mosamala, kuphatikiza ndi Danazole kumagwiritsidwa ntchito kupewa kupewa hyperglycemic,
• Chlorpromazine amachulukitsa kuchuluka kwa shuga m'magazi, kuchepetsa kutulutsa kwa insulin,
• mankhwalawa antipsychotic amafuna kusintha kwa glucophage,
• glucocorticosteroids amachepetsa kulolera kwa shuga, kuwonjezera kuchuluka kwake m'magazi, angayambitse ketosis,
• ndi diuretic mankhwala, lactic acidosis imayamba,
• jakisoni wa beta-adrenergic agonist amalimbikitsa kuchuluka kwa shuga, ACE zoletsa ndi antihypertensive mankhwala amachepetsa chizindikiro ichi,
• Akaphatikizidwa ndi mankhwala a sulfonylurea, acarbose, salicylates, hypoglycemia
• Amylord, Morphine, Quinidine, Ranitidine amatsogolera kukuwonjezeka kwa kuchuluka kwa ntchito.

Kuyamwa kwa mowa

Kuphatikizidwa komwe kumaphatikizidwa ndi kuphatikiza kwa glucophage ndi mowa. Ethanol mu zakumwa zoledzeretsa zam'mimba zimawonjezera chiopsezo cha lactic acidosis, yomwe imapangidwira ndi zakudya zochepa zopatsa mphamvu, zakudya zama calorie ochepa, kulephera kwa chiwindi. Munthawi yonse ya chithandizo chamankhwala, zakumwa zokhala ndi zakumwa zoledzeretsa ndi mankhwala, kumwa mowa kuyenera kupewedwa.

Migwirizano yogulitsa ndikusunga

Glucophage ikhoza kugulidwa kokha ndi mankhwala. Mankhwalawa amasungidwa kutali ndi ana m'malo amdima pa kutentha mpaka madigiri 25, moyo wa alumali ndi zaka 3-5, kutengera kuchuluka kwa metformin hydrochloride pamapiritsi.

Pali mitundu ingapo yachindunji ndi yosatchulika ya Glucofage. Zoyambazo zikufanana ndi mankhwalawa pophatikizika ndi zina zomwe zimagwira, zomwe zimatengera zomwe zimawonetsedwa. Patsamba lazamankhwala mumatha kupeza zotsatirazi zamafuta omwe amapangidwa m'mafakitale ku Russia ndi mayiko ena:

Mtengo Glucofage 500

Mutha kugula mankhwalawa kudzera pa intaneti kapena m'madipatimenti opanga mankhwala pamtengo, momwe mumakhudzidwira ndi malonda, kuchuluka kwa zinthu zogwiritsidwa ntchito pamapiritsi, kuchuluka kwake phukusi. Mitengo yoyandikira ya mapiritsi idzakhala:

Kukumana kwa metformin hydrochloride, mg

Chiwerengero cha mapiritsi pa paketi iliyonse

Mtengo wa intaneti, ma ruble

Mtengo wa mankhwala mu ruble

Glucophage: malangizo ogwiritsa ntchito ndi kuwunikira

Glucophage ndi mankhwala okhala ndi hypoglycemic effect.

Kutulutsa mawonekedwe ndi kapangidwe kake

Glucophage amapangidwa monga mapiritsi:

• 500 kapena 850 mg: filimu yokutira, yoyera, biconvex, yozungulira, yopingasa - yoyera yoyera (500 mg: ma PC 10. M'matumba, matuza atatu kapena asanu mumakatoni, ma 15 ma PC. 2 kapena matuza a mu bokosi la makatoni, ma PC 20. M'matumba, matuza atatu kapena asanu pamakatoni, 850 mg: ma PC 15. M'matumba, matuza awiri kapena anayi mu bokosi la makatoni, ma PC 20. 3 kapena matuza m'makhadi a makatoni),
• 1000 mg: yokutidwa ndi filimu, yoyera, biconvex, chowulungika, chokhala ndi notch mbali zonse ziwiri ndi cholembedwa "1000" mbali imodzi, gawo lamtundu wa yunifolomu yoyera (zidutswa 10 m'matuza, 3, 5, 6 kapena Zotulutsa 12 pamatoni okhala ndi makatoni, ma PC 15. M'matumba, matuza 2, 3 kapena 4 mu mtolo wa makatoni).

Piritsi limodzi lili ndi:

• Mphamvu yogwira: metformin hydrochloride - 500, 850 kapena 1000 mg,
• Zothandiza zothandizirana (motengera): povidone - 20/34/40 mg, magnesium stearate - 5 / 8.5 / 10 mg.

Zomwe zimapangidwa ndi chipolopolo:

• 500 ndi 850 mg mapiritsi (motero): hypromellose - 4 / 6.8 mg,
• Mapiritsi a 1000 mg: opadray oyera (macrogol 400 - 4.55%, hypromellose - 90.9%, macrogol 8000 - 4.55%) - 21 mg.

Glucophage pa opareshoni

Ngati wodwala wakonzekera kuchitidwa opaleshoni, metformin iyenera kuthetsedwa masiku atatu lisanachitike tsiku la opareshoni. Kuyambiranso kwa mankhwalawa kumachitika pokhapokha atatha kuphunzira za impso, ntchito yomwe idapezeka kuti ikukhutiritsa. Pankhaniyi, Glucofage imatha kutengedwa tsiku lachinayi atachitidwa opaleshoni.

Mimba komanso kuyamwa

Matenda osawerengeka omwe ali ndi shuga panthawi yoyembekezera amawonjezera ngozi ya kubadwa kwa mwana wosabadwa ndi infinatal infa. Umboni woperewera kuchokera ku kafukufuku wazachipatala umatsimikizira kuti kutenga Metformin mwa odwala omwe ali ndi pakati sikungakulitse chiwopsezo chodziwika bwino mwa akhanda.

Pokonzekera kukhala ndi pakati, komanso ngati mimba imachitika pakumwa mankhwala a Glucofage ngati muli ndi matenda osokoneza bongo a prediabetes, mtundu wa mankhwala uyenera kuthetsedwa. Odwala omwe ali ndi matenda a shuga a 2 amapatsidwa mankhwala a insulin. Madzi a glucose a plasma amayenera kusungidwa pamlingo woyandikira kwambiri kuti achepetse chiopsezo cha kusokonezeka kwa kubereka kwa mwana wosabadwayo.

Metformin imatsimikiziridwa mu mkaka wa m'mawere. Zotsatira zoyipa za akhanda pakubwera pakumwa ma Glucofage sizinawoneke. Komabe, popeza chidziwitso chogwiritsira ntchito mankhwalawa m'gululi pakadali pano sichokwanira, kugwiritsa ntchito metformin panthawi yotsekemera sikulimbikitsidwa. Lingaliro la kusiya kapena kupitiriza kuyamwitsa limapangidwa pambuyo pabwino la kuyamwitsa ndi chiopsezo chotengera zovuta zomwe zimayambira khanda.

Glucophage kuwonda

Tiyenera kudziwa kuti mankhwalawa ndiwodziwika kwambiri pakati pa anthu oonda. Komabe, ndemanga za madotolo amati njira iyi yothetsera kunenepa kwambiri ndi yowopsa ndipo ingayambitse zovuta zazikulu. Komabe, njirayi imakambidwa m'malo osiyanasiyana momwe ogwiritsa ntchito ali ndi chidwi ndi momwe angatenge Glucophage kuti achepetse thupi.

Nthawi yomweyo, anthu ena amalimbikitsa kutenga Glucofage 500 mg, ndikufotokozera kuti mlingo wotere ungakhale wokwanira "kuyamba njira za metabolic". Ena, m'malo mwake, alangize Glucofage 850 mg, popeza mlingo wapamwamba "ungofulumizitsa ntchitoyi."

Chosangalatsa ndichakuti, kuwerengetsa kunenepa pogwiritsa ntchito mankhwalawa kulibe tanthauzo la zotsatira zina. Koma nthawi imodzimodziyo, pamakhala malipoti akucheperachepera kwamunthu, kupweteka kwam'mimba, nseru, ngakhale kusanza. Chifukwa chake, akatswiri amalangizidwa kuti ayang'anire kuwunika kwawo, komwe kuyenera kukhala kwathunthu. Ndikofunikira kupatula lokoma, ufa ndi mafuta pazakudya ndikuwonjezera zolimbitsa thupi.

Ndemanga za Glucofage

Nthawi zambiri, kukambirana za mankhwalawa kumalumikizidwa ndi kugwiritsidwa ntchito kwake pakuchepetsa thupi. Nthawi yomweyo, ndemanga zina za omwe amachepetsa thupi za Glucofage akuti adokotala adalimbikitsa njira iyi kwa iwo, popeza kudya zakudya komanso kuchita masewera olimbitsa thupi sizinathandize kuthetsa kunenepa kwambiri. Ogwiritsa ntchito ena ali ndi chidwi ndi momwe angamwe mankhwalawa kuti achepetse thupi mofulumira. Kuphatikiza apo, wina akhoza kupeza nkhani za odwala omwe adamwa mapiritsi awa kuti abwezeretse ntchito yobereka.

Komabe, kugwiritsa ntchito mankhwalawa pazolinga zoterezi sikothandiza konse. Komanso, kuwunika konse kwa madotolo ndi odwala kumakhala ndi chidziwitso pakukula kwa zovuta zazikulu za maziko a kuyesayesa kumeneku.

Ndemanga za Glucofage kuti muchepetse kunenepa sikufotokozanso zotsatira zenizeni. Ngakhale odwala omwe amamwa mankhwalawo, muwone kugwira kwake ntchito ndi kuchepa pang'onopang'ono m'thupi.

Kuyesa kwa impso

Metformin imakumbidwa ndi impso, kotero kuyamba kwa chithandizo kumagwirizanitsidwa nthawi zonse ndi kuyesedwa kwa labotale (kuwerengera kwa creatinine). Kwa iwo omwe ntchito ya impso yake siili ndi vuto, ndizokwanira kuchititsa maphunziro azachipatala kamodzi pachaka. Kwa anthu omwe ali pachiwopsezo, komanso odwala okalamba, kutsimikiza kwa QC (kuchuluka kwa creatinine) kuyenera kuchitidwa kangapo pachaka.

Ngati ma diuretics ndi mankhwala a antihypertensive amaperekedwa kwa anthu okalamba, kuwonongeka kwa impso kumatha kuchitika, zomwe zimangotanthauza kufunikira kokawunika mosamala madokotala.

Glucophage mwa ana

Kwa ana, mankhwalawa amadziwitsidwa pokhapokha ngati mayesowo awatsimikizira pakutsimikizira kwawo.

Maphunziro azachipatala ayeneranso kutsimikizira chitetezo cha mwana (kukula ndi kutha msinkhu). Kuyang'aniridwa kwachipatala pafupipafupi pochiza ana ndi achinyamata kumafunika.

Njira zopewera kupewa ngozi

Muziwongolera zakudya zomwe zakudya zimayenera kudyedwa mokwanira komanso moyenera.

Ngati ndinu onenepa kwambiri, mutha kupitiliza kudya kwa hypocaloric, koma pokhapokha pazoyambira 1000 - 1500 kcal tsiku lililonse.

Ndikofunikira. Kuyeserera pafupipafupi kwa maulamuliro kuyenera kukhala lamulo lovomerezeka kwa onse omwe amamwa mankhwalawa Glucofage.

Glucophage ndi kuyendetsa

Kugwiritsa ntchito mankhwalawa nthawi zambiri sikugwirizana ndi vuto loyendetsa kapena magwiridwe antchito. Koma chithandizo chovuta kwambiri chimatha kukhala pachiwopsezo cha hypoglycemia. Pankhaniyi, muyenera kufunsa dokotala.

LIPHA-SANTE Merck KGaA / Merck Sante SAAS Merck Sante SAA.S. Merck Sante SAAS / Nanolek LLC Nycomed Austria GmbH / Merck Sante SAA Nycomed Oranienburg GmbH

Kufotokozera za mtundu wa kipimo

• Mapiritsi otetezedwa osasunthika Mapiritsi otulutsidwa amtundu woyera kapena pafupi ndi utoto, woboola kapisozi, wa biconvex, wolemba "500" mbali imodzi. Mapiritsi okhala ndi manja nthawi yayitali kapena oyera, pafupifupi kapangidwe kake, biconvex, wolemba "500" mbali imodzi. Mapiritsi okhala ndi manja nthawi yayitali kapena pafupifupi oyera, okhala ndi kapisozi, biconvex, wokhala ndi zolemba "750" mbali imodzi ndi "Merck" mbali inayo. Mapiritsiwa ndi zokutira-zoyera, zokhala ndi filimu, kuzungulira, biconvex, pamtanda - wopepuka wazoyera. biconvex. Mapiritsiwa ndi zokutira-zoyera, zokhala ndi filimu, kuzungulira, biconvex, pamtanda - wopepuka wazoyera. Mapiritsiwa ndi zokutira-oyera, opaka mafilimu, oval, biconvex, omwe ali ndi notch mbali zonse ziwiri ndipo amalemba ndi "1000" mbali imodzi, ndi choyera choyera pamtanda.

Mikhalidwe yapadera

• 1 tabu metformin hydrochloride 500 mg Othandizira: sodium carmellose - 50 mg, hypromellose 2910 - 10 mg, hypromellose 2208 - 358 mg, microcrystalline cellulose - 102 mg, magnesium stearate - 3.5 mg. Piritsi limodzi lili: metformin hydrochloride 750 mg Othandizira: sodium carmellose - 37,5 mg, hypromellose 2208 - 294.24 mg, magnesium stearate - 5.3 mg. metformin hydrochloride 1000 mg Othandizira: povidone, magnesium stearate. Zomwe zimapangidwa ndi membrane wa kanema: opadray oyera (hypromellose, macrogol 400, macrogol 8000). metformin hydrochloride 500 mg Othandizira: povidone, magnesium stearate. Zomwe zimapangidwa ndi nembanemba wa filimu: hypromellose. metformin hydrochloride 500 mg Othandizira: sodium carmellose, hypromellose 2910, hypromellose 2208, microcrystalline cellulose, magnesium stearate. metformin hydrochloride 750 mg Othandizira: sodium carmellose - 37,5 mg, hypromellose 2208 - 294.24 mg, magnesium stearate - 5.3 mg. metformin hydrochloride 850 mg Othandizira: povidone, magnesium stearate. Kuphatikizidwa kwamafilimu: hypromellose

Glucophage mavuto

• Zotsatira zoyipa zimaperekedwa kuti muchepetse kufunika kwake: Kuchokera kumbali yamanjenje: kawirikawiri - kusokonezedwa kwa kukomoka (kulawa kwazitsulo mkamwa - 3%).Kuchokera pamatumbo am'mimba: pafupipafupi - nseru, kusanza, kutsegula m'mimba, kupweteka kwam'mimba komanso kusowa kwa chakudya. Nthawi zambiri zimachitika nthawi yoyamba ya chithandizo ndipo nthawi zambiri zimadutsa zokha. Popewa Zizindikiro, tikulimbikitsidwa kumwa metformin nthawi yakudya kapena itatha, kugawa mlingo wa tsiku ndi tsiku mu 2 Mlingo / Kuchepa kwa mlingo kungapangitse kulolerana kwamatumbo. Ngati zizindikiro zikupitilira kwa nthawi yayitali, muyenera kusiya kumwa mankhwalawo ndi kupita kwa dokotala. Dermatological zimachitika: kawirikawiri - erythema, pruritus, urticaria. Kuchokera kumbali ya kagayidwe: kawirikawiri - lactic acidosis. Odwala omwe amathandizidwa ndi metformin kwa nthawi yayitali amatha kumva kuchepa kwa vitamini B12, limodzi ndi kuchepa kwake. Ngati matenda am'madzi a megaloblastic apezeka, mwayi wa etiology wotere uyenera kuganiziridwa. Zizindikiro zoyambirira za lactic acidosis ndi mseru, kusanza, kutsegula m'mimba, kuchepa kwa kutentha kwa thupi, kupweteka kwam'mimba, kupweteka kwa minofu, mtsogolo kungakhale kupuma kwambiri, chizungulire, chikumbumtima chosautsa komanso kukula kwa chikomokere. Kumbali ya dongosolo la hepatobiliary: pali malipoti ochepa a chiwindi chodwala kapena chiwindi, atatha kufooka kwa metformin, zotsatira zosafunikira zikazimiririka.

Malo osungira

• sitolo firiji 15-25 madigiri
• osayandikira ana
• sungani pamalo amdima

• Bagomet, Vero-Metformin, Gliminfor, Glformin, Glucofag, Dianormet, Dormin retard, Metfogamma 500, Metfogamma 850, Metformin, Metformin-BMS, Siofor 500, Siofor 850, Fomu Pliva

Glucophage 850 ndi mankhwala okhala ndi katundu wa hypoglycemic. Mankhwalawa amapangidwira pakamwa. Mankhwalawa ndi a gulu la Biguanides.

Glucophage imathandizira kuchepetsa kuchuluka kwa hyperglycemia ndipo sikumapangitsa kuti thupi la wodwalayo lizioneka ngati ali ndi vuto la hypoglycemia. Chimodzi mwa mankhwalawa ndiko kusowa kwa mphamvu ya yogwira popanga njira zama insulin.

Kugwiritsa ntchito mankhwalawa kumathandiza kupewetsa kayendedwe ka gluconeogenesis ndi glucogenolysis. Kugwiritsa ntchito mankhwala kungathandize kuchepetsa kuyamwa kwa glucose kuchokera m'matumbo a lumen kulowa m'magazi.

Kudya kwa Glucofage 850 mg m'thupi kumabweretsa kukondoweza kwa magwiritsidwe amtundu wa glycogen pogwiritsa ntchito mankhwala omwe amagwira pa glucogen synthetase enzyme. Kugwiritsa ntchito shuga kumapangitsanso mayendedwe amtundu uliwonse wamatenda a glucose oyenda.

Kugwiritsa ntchito mankhwalawa kumawonjezera zina zabwino. Glucophage imatha kukopa metabolidi ya lipid. Ndi kuyambitsa ntchito yogwira mankhwala m'thupi, kuchuluka kwa cholesterol, LDL ndi TG m'thupi kumachepa.

Kumwa mankhwala kumathandizira kuchepetsa kulemera kwa thupi la wodwalayo ngati chizolowezi chadutsa kapena chikakhazikika pamlingo womwewo.

Migwirizano ndi magwiritsidwe akusungidwa

Pewani kufikira ana pa kutentha mpaka 25 ° C.

• 500 ndi 850 mg mapiritsi - zaka 5,
• Mapiritsi a 1000 mg - zaka 3.

Ndani mwa achinyamata amakono omwe safuna kukhala wocheperako komanso wokhala ndi mawonekedwe okongola? Koma kupanga zakudya zoyenera ndi kuchita masewera olimbitsa thupi nthawi zonse kumakhala kovuta, chifukwa muyenera kukhala ndi mphamvu kuti muwone cholinga ndikukwaniritsa zotsatira. Ndiosavuta kumwa mankhwala ozizwitsa ndikuchepetsa mphamvu yokhala pa sofa kukumbatirana ndimakoko ndi tchipisi.

Nthawi zambiri anthu amadzisankhira okha mankhwala omwe angagulidwe ku pharmacy, ndikuyamba kumwa poyembekezera kuti ataya pafupifupi 10 kg pa sabata.Nthawi zambiri, iwo amene akufuna kuchepa thupi alibe chidwi ndi cholinga chachikulu cha mankhwala omwe adagula. Lero tikulankhula za mankhwala monga Glucofage. Ndemanga yakuchepetsa thupi amanenapo za iye ngati njira yothandiza kwambiri yochepetsera thupi, pomwe mankhwalawa amapangidwira odwala omwe ali ndi matenda a shuga a mtundu wachiwiri.

The kapangidwe ndi kumasulidwa mawonekedwe a mankhwala "Glucofage

Metformin hydrochloride ndiye chinthu chogwira ntchito cha mankhwalawo. Zothandiza ndi izi: magnesium stearate, povidone, hypromellose (2910 ndi 2208). Mankhwalawa amapezeka mu mawonekedwe am'mapiritsi omwe ali ndi Mlingo wothandizirana ndi kuchuluka kwa 500, 850 ndi 1000 mg. Mapiritsi a Biconvex ndiwotupa. Amatetezedwa ndi chovala choyera cha filimu. Pali zoopsa kumbali zonse za piritsi, pa imodzi mwa izo mwawonetsedwa.

Komanso ogula amapatsidwa wothandizira kuti amasulidwe - Glucofage Long. Ndemanga za ogwiritsa ntchito mankhwalawa zimawonekera pamankhwala abwino. Mankhwala omwe amafunsidwa kawirikawiri m'mafakisoni ndi 500 ndi 750 mg ya metformin.

Kugwirizana kwa "Glucophage" ndi kuwonda: mfundo yofunikira

Gawo lalikulu la mankhwalawa, metformin, limapangidwa kuti muchepetse kuchuluka kwa shuga m'magazi, omwe amawonjezereka atatha kudya (njira yachilengedwe yachilengedwe) yamoyo. Kenako kapamba amalumikizidwa ndi njirayi, ntchito zomwe zimaphatikizapo kupanga, kenako, kusintha glucose kukhala maselo amafuta.

Mwa zabwino zazikulu za mankhwala "Glucofage Long" chifukwa cha kuwonda, zotsatirazi zitha kudziwika:

• matenda a lipid metabolism osagwirizana ndi matenda a shuga,
• kuletsa kuwonongeka kwa mafuta omwe amalandiridwa ndi chakudya, ndipo, potero, kusintha kwawo kukhala mafuta amthupi,
• kuwunikira komanso kusintha matenda a shuga ndi mafuta “oyipa” omwe ali m'magazi,
• kuchepa kwachilengedwe pachilakolako ndi kusilira kwa maswiti, komwe kumalumikizidwa ndi kubereka kwa kapangidwe ka insulin.

Zinthu zonsezi pamodzi zimathandizira odwala matenda ashuga kuwongolera kuchuluka kwa shuga ndikuwongolera kwambiri moyo wawo potengera njira za endocrine.

Mphamvu ya metformin imayambitsa kutsika kwa glucose wamagazi, ndipo mamolekyulu a shuga amayenda molunjika kumtunda. Ndi pomwepo kuti shuga amawotcha kwambiri, kuyamwa kwa michere kumachitika ndikuchepetsa (mwachitsanzo, kuchuluka ndi kuchuluka kwa maselo amafuta sikumachitika).

Kuphatikiza apo, mankhwala a Glyukofazh ndi Glyukofazh Long, kuwunika kwa iwo omwe achepetsa thupi kumawapatsa mwayi wochepetsa kudya, chifukwa chomwe palibe kudya kwambiri ndipo, chifukwa chake, insulin imatulutsidwa m'magazi.

Mlingo komanso dongosolo la momwe mungagwiritsire ntchito

Mankhwala "Glucofage Long" samalimbikitsa kutenga malangizo ogwiritsa ntchito popanda mankhwala a dokotala. Ngakhale kuchuluka kokwanira kwa ogwira ntchito yazaumoyo ali ndi chiyembekezo chogwiritsa ntchito zopangidwa ndi metformin kuti muchepetse kunenepa.

Mitundu yovomerezeka ndi njira yochizira kuyambira masiku 10 mpaka 22, ndiye kuti muyenera kupuma kwa miyezi iwiri. Pakapita kanthawi, maphunzirowo atha kubwerezedwa. Pogwiritsa ntchito pafupipafupi, pamakhala mwayi kuti thupi lizisinthasintha (kugwiritsa ntchito) mankhwalawa ndikuchepetsa mphamvu, zomwe zikutanthauza kuti metformin imataya mwayi wowonetsa bwino mawonekedwe owotchera mafuta.

Dokotala amasankha mulingo woyenera aliyense payekha kwa wodwala aliyense, kutengera mtundu waumoyo komanso magawo a anthropometric (kulemera, kutalika, msinkhu). Kuchuluka kwa tsiku lililonse kwa mankhwalawa ndi 500 mg. Nthawi zambiri kumwa mapiritsi usiku. Komabe, nthawi zambiri "Glucofage 500" yochepetsa thupi imayikidwa kawiri masana, nthawi ya nkhomaliro komanso madzulo. Pafupipafupi, mlingo ungathe kuwonjezeredwa mpaka 3 Mlingo - 1,500 mg patsiku (mwachilengedwe, osati palokha, koma monga momwe adanenera dokotala).Pankhaniyi, ndizomveka kuyang'anira magwiridwe anthawi yayitali "Glucofage Long 750" kuti muchepetse kunenepa. Kuunika kwa madotolo ndi odwala kumawonetsa chida ichi kukhala chothandiza komanso chosavuta kugwiritsa ntchito (1500 mg mu Mlingo iwiri). Mapiritsi aledzera musanadye kapena nthawi ya chakudya.

Mlingo wapamwamba wa tsiku lililonse wa mankhwalawa (apanso, monga momwe adanenera dokotala) sangadutse 3000 mg. Ndi kumwa motere, ndibwino kuti muthe kutenga Glucofage 1000 kuti muchepetse thupi (katatu patsiku piritsi lokhala ndi metformin mu 1000 mg).

Kuchepetsa pang'onopang'ono kwa mankhwalawa kungakhudze kukonzekera kwa m'mimba kwa mankhwalawa.

Ndani ayenera kupewa kugwiritsa ntchito mankhwalawa?

Popeza Glucofage sikuti ndi vitamini kapena zakudya zowonjezera, koma adapangira kuti azigwiritsidwa ntchito ndi odwala omwe ali ndi matenda amtundu wa 2, ali ndi mndandanda wochititsa chidwi wa zotsutsana.

Anthu athanzi omwe amamwa mankhwala a metformin amakhala ndi chiopsezo chokhala ndi vuto la kuperewera kwa thupi, lomwe limadziwonetsa pang'onopang'ono momwe thupi la munthu limayendera insulin yake. Izi zimadzetsa chitukuko cha matenda ashuga.

Kupitilira apo, onse Glucofage ndi Glucofage Long amaletsa kugwiritsa ntchito malangizo kwa anthu omwe ali ndi chidwi chochulukirapo pazigawo zina. Kupatuka kulikonse pakugwira ntchito kwa impso, chiwindi, mtima ndi zifukwa zokwanira zokanira kugwiritsa ntchito mankhwalawa. Matenda aliwonse omwe ali pachimake kwambiri, nthawi yokonzanso ntchito, kupweteka kwa thupi, mkaka - izi zonse zimaletsa kugwiritsa ntchito "Glucofage" kuchepetsa thupi.

Musamwe mankhwala kwa odwala omwe ali ndi vuto lililonse la matenda ashuga: odwala matenda amtundu 1, komanso mtundu uwu wa matenda ashuga 2, pomwe wodwalayo alibe insulin mthupi. Sizoletsedwa kutenga Glucophage kwa anthu omwe ali ndi magazi m'thupi, matenda oopsa a bronchopulmonary, mavuto amtundu wa hematological momwe magazi acid apamwamba kuposa abwinobwino.

Mawonetsero osayenera

Popeza mankhwalawa adapangidwa kuti athane ndi matenda oopsa monga matenda a shuga, sangalephere kukhala ndi zotsatirapo zilizonse. Nthawi zambiri, pamakhala zotsatira zoyenera kumwa mankhwalawa "Glucophage". Ndemanga ya kuchepetsa kulemera imafunsa mitundu yosiyanasiyana yamatumbo am'mimba.

Ngati, motsutsana ndi maziko ogwiritsa ntchito mankhwala okhala ndi metformin kuti muchepetse kunenepa, kutsekula m'mimba kumapangika kapena kupanga magesi m'matumbo kumachulukitsa, ndiye chifukwa chake chingakhale chakudya chochuluka cha chakudya. Muyenera kuwerengera zomwe mumadya tsiku lililonse. Ngati mukusanza mukamwa mankhwalawa, muyenera kuchepetsa kuchuluka kwa mankhwalawa. Nthawi zambiri mumatha kumva za ma spasms m'matumbo ndi mutu womwe umachoka mwachangu.

Popereka mankhwala a Glucophage ndi Glucophage Long slimming kwa odwala, kuwunika kuyeneranso kukumbukiridwa. Ogwira ntchito zachipatala ati kuchuluka kwa zotsatirapo zake kumazimiririka lokha patatha masiku ochepa chiyambireni mankhwalawa kapena atangomaliza kumwa.

Pamaso pa zinthu zomwe zimayambitsa vuto, lactic acidosis imayamba. Kuchita koteroko kumawonedwa kukhala koopsa kwambiri. Chofunikira chake ndikukulitsa maphunziro komanso kagayidwe kosayenera m'thupi. Zizindikiro zotsatirazi zikuwonetsa kukhalapo kwa mankhwalawa "Glucophage": kusanza, kutsegula m'mimba, kupumira mwachangu, kupweteka m'mimba, kusazindikira. Kukula kwa zotere kumafunika kuchotsedwa kwa mankhwalawo, kuchipatala mwachangu kuti mupeze mulingo wa lactate m'magazi komanso molingana ndi zotsatira za chithandizo chamankhwala. Pochotsa metformin ndi mkaka wa mthupi, chithandizocho chikhala chothandiza kwambiri.

Kukhazikika kosagwiritsidwa ntchito kwa mankhwalawa pogwiritsa ntchito metformin kumatha kuyambitsa zovuta mu ubongo.

Ngakhale odwala omwe amamwa mankhwala mu Mlingo wocheperako (kuyambira Glucofage 500) chifukwa cha kuchepa thupi amatha kukhala ndi malingaliro olakwika kwambiri ngati malangizo osagwiritsidwa ntchito satsatiridwa. Muyenera kusiya zakudya zomwe zili ndi chakudya chochuluka: zipatso zouma, koloko, maswiti ndi zakudya zina zokhala ndi shuga. Zosathandiza kwambiri panthawiyi azikhala kudya chimanga, mbatata, pasitala ndi mpunga woyera.

Kugwiritsa ntchito mankhwala okhala ndi metformin motsutsana ndi zakudya zama calorie otsika (zakudya zosaposa 1000 kcal) zomwe zimakhala ndi zakumwa zoledzeretsa ndi zakumwa sizigwirizana kwenikweni.

Palibe zakudya zapadera mukamagwiritsa ntchito Glucofage. Palibe zoletsa zapadera pa zonunkhira ndi mchere mwina.

Kuchita ndi mankhwala ena

Zambiri pazomwe mungatengere "Glucophage" zili m'malangizo ogwiritsira ntchito mankhwalawa. Kudya limodzi ndi danazol kungapangitse kukula kwa vuto la hyperglycemic. Kugwiritsa ntchito munthawi yomweyo kukonzekera kwa metformin ndi zinthu za ethanol kumatha kuyambitsa lactic acidosis panthawi yamkati poyizoni wakumwa. Kuthekera kotenga gawo lotereli kumakulirakulira ndi njala, zakudya zopatsa mphamvu pang'ono komanso kulephera kwa chiwindi.

Odwala omwe ali ndi matenda ashuga ayenera kusamala akamagwiritsa ntchito Glucofage ndi antipsychotic kapena glucocorticosteroids (GCS). Zikatero, mlingo wa mankhwala omwe ali ndi metformin uyenera kusinthidwa malinga ndi kuchuluka kwa shuga m'magazi. Kuphatikiza kwa Glucophage ndi loopback diuretics kumafunikanso chisamaliro chapadera. Zikatero, pamakhala chiopsezo pakupatuka kwa impso ndipo, chifukwa chake, kukula kwa zizindikiritso za lactic acidosis.

Mankhwala othandizira magazi amatha kuchepetsa magazi. Chifukwa chake, pakafunika "mdera" lotere, muyeso wa metformin uyenera kusinthidwa.

Fomu lamasulidwe a Glucofage

• Izi zimapezeka mosiyanasiyana mu mawonekedwe a piritsi, kukhala ndi mtundu wina
• Mapiritsiwo ndi ozungulira kapena ozungulira, amapota. Mlingo 500 mg, 850 mg ndi 100 mg
• Chidachi chimalowetsedwa mwachangu kulowa m'magazi ndikufalikira kudzera mu minofu, pomwe sichimamanga kumapuloteni amwazi. Mankhwalawa amachotsa impso ndipo pafupifupi samaphwanya

Glucophage ndi zolimbitsa thupi

Osati kale kwambiri, ponena za kuchita zolimbitsa thupi komanso kugwiritsa ntchito mankhwala a Glucofage, kuwunika kwa kunenepa kwambiri ndipo ogwira ntchito zachipatala adavomereza kuti muzochitika zoterezi zimathandizira kwambiri, chifukwa lactic acid imatulutsidwa m'mitsempha, yomwe imanyalanyaza mphamvu ya mankhwalawa chifukwa cha kuchuluka kwa acidity magazi. Komabe, kafukufuku waposachedwa m'derali watsimikizira zokayikitsa. Komanso, tsopano zikuwonekeratu kuti Glucophage ndi moyo wokangalika pamodzi zimathandizira njira yochepetsera thupi.

Ngakhale mutatenga mankhwala ochepa a metformin (mwachitsanzo, Glucofage 500), kuwunikira kwa kuchepetsa thupi (omwe saiwala zolimbitsa thupi) nthawi zambiri kumakhala koyenera. Chowonadi ndi chakuti gawo lalikulu la mankhwalawo limathandizira kuperekera shuga mwachindunji m'matumbo, komwe amawotcha bwino, ngati munthu amene akufuna kuchepa thupi saayiwala za masewera olimbitsa thupi. Kupanda kutero, ma metabolic a thupi "amayendetsa" glucose mozungulira mpaka atatembenuka kukhala glycogen ndipo sasintha kukhala mafuta.Chifukwa chake, mathedwe amadzitsimikizira okha: Asanatenge "Glucophage", ndikofunikira kupanga pulogalamu yochita zolimbitsa thupi ndikutsatira mosamalitsa. Ndi pokhapo izi pomwe zotsatira zabwino zingayembekezeredwe.

Kodi lingaliro la ogwira ntchito yazaumoyo ndi chiyani pa Glucofage?

Pakadali pano, madokotala alibe mgwirizano pa kutha ndi chitetezo cha metformin pakuchepetsa thupi. Chithandizo chamankhwala sichimaletsa kugwiritsa ntchito Glucophage ndi Glucophage Long pochizira kunenepa. Ndemanga za akatswiri ambiri azachipatala ndi zabwino. Ngakhale gawo lina la madokotala silimawona kuti chithandizo chotere sichobvomerezeka, chifukwa mankhwalawa angapangitse kupatuka mu kayendedwe ka car metabolic metabolism, amachititsa kukula kwa matenda a shuga ndi lactic acidosis, omwe amawopseza moyo wa wodwalayo.

Pofuna kumveketsa chowonadi mmaiko ambiri padziko lapansi, maphunziro oyenerera akuchitika pankhaniyi. Chifukwa chake, mu 2014, maphunziro adachitika pamaziko a Cardiff University, momwe anthu pafupifupi 180,000 adatenga nawo gawo. Zotsatira zake, zidatsimikiziridwa kuti metformin ndi kukonzekera komwe kuli nako kumatha kuwonjezera kuchuluka kwa moyo osati mwa anthu omwe ali ndi matenda ashuga okha, komanso mwa iwo omwe sazindikira. Kuphatikiza apo, zidapezeka kuti kugwiritsa ntchito metformin kumachepetsa kukalamba mthupi.

Malingaliro odwala

Popeza makambirano sakukhudzana ndi zowonjezera mavitamini kapena mavitamini, koma za mankhwala oopsa, sizachilengedwe kuti pamakhala malingaliro osiyanasiyana za iwo pakati pa ogula.

Kumbali imodzi, odwala omwe adamwa ngakhale mankhwala ochepa kwambiri (mwachitsanzo, nthawi imodzi yotsatila Glucofage 500), ndemanga zimasiya zabwino kwambiri pamankhwala. Ndipo kuchepa kwa njala kumawonekera, ndipo kulemera kwamthupi kumachepa. Zowona, ena amakhulupirira kuti kulemera kumachepetsedwa pang'onopang'ono, 2-3 kg kupitilira mwezi. Komabe, ogwira ntchito yazaumoyo amawona kuti mlingo uwu ndiwopeza bwino kwambiri thupi lonse. Chofunika kwambiri, musadzipangire nokha. Onetsetsani kuti mukumana ndi dokotala yemwe amayesa momwe wodwalayo alili, aganize kutalika kwake, kuchuluka kwake, msinkhu wake, sankhani mlingo woyenera kwambiri ndikukhala ndi njira yabwino yokwanira.

Pali odwala omwe anayesera kutenga Glucofage (okha, chifukwa katswiri woyenera wamankhwala sangapange nthawi yoikidwiratu) kuti apange minofu pomanga thupi. Apa muyenera kudziwa kuti limagwirira a anabolic, yomwe ndiyofunikira kwambiri kuti minofu ikule, imayambitsa mndandanda wonse wa zinthu, kuphatikizapo glucose ndi insulin. Ndipo "Glucophage" ndi mankhwala aliwonse okhala ndi Metformin amapangitsa kuti thupi lipangike, lofanana ndi njala, lomwe limabwera atatha kulimbitsa thupi. Chifukwa chake, kuwunikira kwa odwala kotere kuti mankhwalawa sanathandize.

Pali zovuta zokwanira zogwiritsa ntchito mankhwalawa "Glucofage." Ndemanga ya kuchepa thupi lipoti la kuchepa mphamvu, kakulidwe kazotsatira zoyipa. Zikatero, wina sakanakhoza kulekerera kwa masiku angapo mpaka thupi litazungulira ku Glucofage. Kwa ena, kukhalapo kwa matenda othandizirana kumadzetsa mavuto ambiri, ndipo simungathe kuchita kalikonse pano - muyenera kulabadira mankhwala ena kuti muchepetse kunenepa. Ndipo wina sanalandire malingaliro a malangizo omwe angagwiritsidwe ntchito pakuchepetsa kudya kwa zakudya zamagulu ochulukirapo, kusakanikirana kophatikiza metformin ndi zakudya zama calorie ochepa, zinthu zakumwa zoledzeretsa, okodzetsa, antipsychotic ndi zinthu zina.

Nthawi zambiri, ndemanga zoyipa zokhudza Glucofage zitha kunenedwa pokhapokha ngati mankhwalawa akumwa, omwe amachokera ku gulu lalikulu, amapangidwira makamaka odwala matenda a shuga, ndipo amatha kusokoneza kagayidwe kazakudya mwa munthu wathanzi.

Ubwino wa mankhwalawa ndikuti Glucofage ndi yotsika mtengo kwambiri ndipo imagulitsidwa pa intaneti yopanda mankhwala popanda mankhwala, zomwe zimapangitsa kuti anthu athe kupeza ndalama iliyonse.

Mulimonsemo, musanapitirize ndi kulandira Glucofage kuti muchepetse kunenepa, muyenera kufunsa uphungu wa akatswiri azachipatala omwe ali ndi mbiri yoyenera. Iyi ndiye njira yokhayo yopezera zotsatira zabwino popanda kuyika thupi lanu pangozi.

Mapiritsi ali ndi zomwe zimagwira - metformin hydrochloride500, 850, 1000 mg aliyense.

Zosakaniza zina: povidone ndi magnesium stearate.

Utoto wamafilimuwo umakhala ndi hypromellose, ndipo mapiritsi a 1000 mg amapezekanso ndi Opadry Kli, macrogol 400 ndi 8000.

Kufotokozera kwathunthu kwa mankhwalawa, mawonekedwe ake ndi mawonekedwe ake omasulidwa

Mu mapiritsi Glucofage, mankhwala othandizira omwe amapanga kwambiri ndi metformin, yomwe imakonzekera mawonekedwe a hydrochloride.

Mankhwalawa amapangidwa ngati mapiritsi, omwe amaphatikizidwa ndi zokutira filimu.

Kuphatikiza pazomwe zimagwiritsidwa ntchito popanga mankhwala, kapangidwe kazinthu kameneka kamagwiritsanso ntchito zinthu zina zomwe zimapatsidwa ntchito zothandizira.

Izi zothandiza zomwe zimapanga glucophage ndi:

Utoto wamafilimu wa mankhwalawo umaphatikizanso mu mawonekedwe ake monga hypromellase.

Mapiritsiwo amakhala ndi mawonekedwe a biconvex. Mukuwoneka, gawo lamtanda la phale ndi unyinji wowoneka bwino wokhala ndi khungu loyera.

Mankhwalawa amadzaza m'matumba a 20 mapiritsi. Mapaketi atatu amtunduwu amaikidwa m'matumba, omwe amakhalanso ndi malangizo ogwiritsira ntchito mankhwalawa.

Mankhwalawa amagwiritsidwa ntchito pochiza matenda amishuga amitundu iwiri, monga monotherapy komanso pochita zovuta za mtundu wa matenda a shuga 2.

Kugwiritsa ntchito glucophage pamaso pa matenda a shuga m'magonedwe kumatha kuchepetsa matendawa. Kugwiritsa ntchito mankhwalawa popewa matenda ashuga kupezeka kwa matenda a prediabetes m'thupi kungathandize kuchepetsa mwayi wokhala ndi matenda ashuga.

Kugwiritsa ntchito mankhwalawa kumakuthandizani kuti muzitha kuyendetsa bwino.

Pharmacokinetics ndi pharmacodynamics a mankhwalawa

Mutamwa mankhwalawo, gawo lalikulu la mankhwalawo limatsitsidwa kuchokera kumimba. Mankhwala amaphatikizidwa bwino. The bioavailability wa mankhwala mthupi la munthu pafupifupi 50-60%.

Pizere kwambiri ya mankhwalawa imapezeka pafupifupi maola 2,5 mutatha kumwa mankhwalawa. Mukamamwa mankhwalawa pakudya, kuchuluka kwa mayamwidwe kumachepa. Pambuyo polowera m'magazi, gawo loyeserera lamankhwala limagawidwa mwachangu mthupi lonse la wodwalayo.

Pokonzekera kugwiritsira ntchito metformin hydrochloride pazopaka thupi, sizigwirizana ndi mapuloteni okhala m'madzi a m'magazi.

Metformin sikuti imapukusidwa. Ndipo kutulutsa kwa ntchito yogwira kumachitika ndi impso.

Hafu ya moyo wa yogwira thupi kuchokera kwa thupi ndi pafupifupi 6.5 maola.

Ngati wodwala walephera, impsoyo imakulitsidwa kwambiri, zomwe zimatha kupangitsa kuti thupi lizikundana.

Mukamamwa mankhwalawa monga gawo la zovuta mankhwala, muyenera kuwalandira mosamala pazomwe mankhwala Glucofage amatengedwa. Izi ndichifukwa choti mukamamwa mankhwala ena ndi glucophage, mwayi wokhala ndi vuto la hypoglycemic ukuwonjezeka.

Kuyanjana koteroko pakati pa mankhwala kumafuna kusintha kwa mankhwalawa.

Zizindikiro ndi contraindication ntchito mankhwala

Mankhwalawa amaloledwa kugwiritsidwa ntchito ndi onse akulu ndi ana omwe ali ndi zaka 10.

Monga chida chothandizira kupewa, mankhwalawa amayenera kugwiritsidwa ntchito ngati kusintha kwa moyo ndi zakudya sizikulola kukwaniritsa kukonza shuga mu madzi a m'magazi.

Monga mankhwala aliwonse, Glucophage imakhala ndi zotsutsana zingapo kuti zigwiritsidwe.

Milandu ikuluikulu pakugwiritsa ntchito mankhwalawa ndi iyi:

1. kukhalapo kwa hypersensitivity pazinthu zazikulu kapena zowonjezera zomwe zimapanga mankhwala.
2. Kukhalapo kwa thupi la wodwala wodwala matenda ashuga, matenda ashuga ketoacidosis, diabetes kapena matenda atangoyamba kumene.
3. Kukhalapo kwa wodwala ndi kulephera kwa impso kapena kugwira bwino ntchito kwa impso.
4. The zimachitika pachimake zinthu zomwe zimachitika mthupi ndi kuoneka ngati chiwopsezo cha kusokonezeka kwa impso. Zinthu ngati izi zimaphatikizapo kusowa kwamadzi, kutsegula m'mimba, kapena kusanza.
5. Kukula kwa matenda opatsirana owopsa komanso opatsirana m'thupi komwe kumakhudza kugwira ntchito kwa impso.
6. Kukhalapo kwa wodwala kwamawonekedwe owopsa kapena matenda opweteka kwambiri omwe angayambitse matenda a minofu hypoxia, mwachitsanzo, kulephera kwa mtima, kulephera kwa mtima komwe kumachitika chifukwa cha kusakhazikika kwa magawo a hemodynamic, kupuma, kugunda kwa mtima.
7. Kuchita zodzionetsera zambiri pakagwiritsidwe ntchito ka mankhwala a insulin.
8. Kukhalapo kwa chiwindi kulephera ndi chiwindi cell ntchito.
9. Kukhalapo kwa uchidakwa woperewera kwa wodwala, poyizoni wazakumwa ndi zakumwa zoledzeretsa.
10. Nthawi ya bere ndi kuyamwitsa.
11. Kafukufuku wokhudzana ndi kugwiritsa ntchito mankhwala okhala ndi ayodini monga gulu lina.
12. Kugwiritsa ntchito zakudya zamafuta ochepa.

Zotsatira zoyipa mukamamwa mankhwalawa

Zotsatira zoyipa zomwe zimachitika pakumwa mankhwalawa zimatha kugawidwa m'magulu angapo kutengera kupezeka kwawo.

Nthawi zambiri, mthupi la wodwala mukamagwiritsa ntchito mankhwala Glucofage, zosokoneza zimatulukira mu kagayidwe kachakudya ka kagayidwe kake ndi kagwiritsidwe ntchito ka chakudya m'mimba. Mwina kukula kwa lactic acidosis.

Kugwiritsa ntchito mankhwalawa kwakanthawi kumabweretsa kuchepa kwa mayamwidwe a vitamini B12 wodwala.

Wodwala akaulula zizindikiro za kuchepa kwa magazi m'thupi la megaloblastic, njira zonse zofunika ziyenera kutengedwa nthawi yomweyo kuti muchepetse vuto.

Nthawi zambiri, odwala omwe amagwiritsidwa ntchito ngati mankhwala ochiritsira amakhala akusokoneza malingaliro awo.

Kuchokera m'mimba, mawonekedwe a zoyipa monga:

1. Kumva kupusa.
2. Kubweza.
3. Ululu m'mimba.
4. Anachepetsa chilako.

Nthawi zambiri, zotsatira zoyipazi zimachitika poyambira kumwa mankhwalawo ndipo nthawi zambiri, zotsatira zake zimatha pang'onopang'ono ndikugwiritsanso ntchito mankhwalawa.

Nthawi zina, mukamamwa mankhwalawa, khungu limakhudzika m'njira zosiyanasiyana zotupa ndi kuyabwa.

Matenda a shuga ndi kupsinjika kudzakhala chinthu chakale

Matenda a shuga ndi omwe amayambitsa pafupifupi 80% yonse yamikwingwirima ndi kuduladula. Anthu 7 mwa anthu 10 amafa chifukwa cha mitsempha ya mtima kapena ubongo. Pafupifupi nthawi zonse, chifukwa chomaliza chomaliza ndi chimodzimodzi - shuga wamwazi.

Shuga akhoza ndipo amayenera kugwetsedwa, apo ayi. Koma izi sizichiritsa matendawa, koma zimangothandiza kulimbana ndi kufufuza, osati zomwe zimayambitsa matendawa.

Mankhwala okhawo omwe amavomerezeka pamankhwala othandizira odwala matenda ashuga komanso amagwiritsidwa ntchito ndi ma endocrinologists pantchito yawo ndi awa.

Kugwiritsa ntchito bwino kwa mankhwalawa, kuwerengera malinga ndi njira yokhazikika (kuchuluka kwa odwala omwe achiwonjezere kuchuluka kwa odwala omwe ali pagulu la anthu 100 omwe adachitiridwa chithandizo):

• Matenda a shuga - 95%
• Kuthetsa kwa mitsempha thrombosis - 70%
• Kuthetsa kwa kugunda kwamtima kwamphamvu - 90%
• Kuthana ndi kuthamanga kwa magazi - 92%
• Kuwonjezeka kwa mphamvu masana, kukonza kugona usiku - 97%

Opanga si bungwe lazamalonda ndipo amalipidwa ndi chithandizo cha boma. Chifukwa chake, tsopano wokhala aliyense ali ndi mwayi.

Glucophage kapena Siofor

Siofor ndiye kholo la kampani yaku Germany Berlin-Chemie, mpikisano waukulu wa Glucofage. Kusiyana kwa mankhwala:

1. Chifukwa cha ndondomeko ya wopanga, Siofor nthawi zambiri amalembera anthu omwe ali ndi metabolic syndrome kuti achepetse thupi.
2. Maphunziro a chitetezo ndi luso anali kuchitidwa kokha ndi oyambirirawo.
3. Siofor adayesedwa kokha kuti apeze bioequivalence ndi Glucofage.
4. Mankhwala osokoneza bongo amasiyana pang'ono pakupanga kwa zinthu zofunika kupanga piritsi.
5. Siofor alibe mawonekedwe atali.

Ndemanga za odwala matenda ashuga za mankhwalawa ndizosiyana. Odwala ena amati Siofor amalekeredwa bwino, ena akutsimikiza kuti Glucofage ndiyabwino. Enanso samawona kusiyana kulikonse ndikugula mapiritsi omwe ali mufiriji yapafupi.

Zokhudza impso ndi chiwindi

Popeza glucophage amathandizidwa ndi impso, kayendetsedwe ka ntchito zawo ndikofunikira pakukhazikitsa. Kuti muchite izi, ndikofunikira kuti onse odwala matenda ashuga azitha kuyesa mkodzo ndi magazi chaka chilichonse. Okalamba, odwala matenda a shuga a nephropathy, ogwiritsira ntchito mankhwalawa kwa nthawi yayitali kukakamiza, okodzetsa, NSAIDs - patatu. Metformin ilibe vuto pa impso. M'malo mwake, kuteteza zombo, kumachepetsa chiopsezo cha nephropathy.

Glucophage imalimbikitsidwa kuti muchepetse kunenepa kwambiri mwa anthu omwe ali ndi vuto logona m'mimba kwambiri, lomwe limatsimikiziridwa ndi hyperinsulinemia (yotsimikiziridwa ndi kapena), "nkhandwe" yosalamulira. Kulandila kuyenera kuphatikizidwa ndi chakudya cha 1200 kcal. Udindo wa Glucophage ndi kukankhira njira yochepetsera thupi, popanda kusintha mphamvu kulibe mphamvu. Malinga ndi ndemanga, pa metformin yopanda chakudya, simungataye kuposa 3 kg. Ngati kunenepa kwambiri kumayambitsidwa chifukwa cha kudya komanso zizolowezi zolakwika, kukana insulini kulibe kapena kopanda tanthauzo, mankhwalawa sangathandize.

Kuti mutenge molondola Glucophage ndi fanizo la kuchepa thupi, muyenera kuwerenga malangizo a anthu odwala matenda ashuga. Ngakhale shuga atakhala wabwinobwino, mankhwalawa aledzera muyeso womwewo: yambani ndi 500 mg ndikuwonjezera pang'onopang'ono mapiritsi anu muyeso wabwino.

Glucophage kuchokera ku ukalamba

Pakadali pano, zolemba zokhudzana ndi mitundu yapadera ya metformin zimapezeka kwambiri m'mabuku azachipatala. Amaganizira kuti amalepheretsa kukalamba, kusokoneza thupi kwathunthu:

• imapangitsa kukula kwa mitsempha,
• imathandizira kubwezeretsa minofu yamitsempha,
• Amathandizanso kuonetsa ziwopsezo zambiri za matenda amisempha,
• imachepetsa kutupa,
• amateteza mtima ndi mitsempha yamagazi,
• amachepetsa chiopsezo cha oncology,
• kuchuluka wamphamvu,
• bwino potency
• kuchedwetsa mafupa
• kumalimbitsa chitetezo chathupi.

Mwanjira ina, mapiritsi a Glucofage amaikidwa ngati mankhwala padziko lonse lapansi pamavuto onse okalamba. Zowona, maphunziro odalirika sanatchulidwe, kotero pakadali pano maloto chabe amtsogolo osangalatsa popanda kukalamba.

Malamulo Ovomerezeka

Lamulo lalikulu la kutenga Glucophage ndiwonjezereka pang'onopang'ono mu mlingo. Mlingo woyambira ndi 500 mg. Amamwa mpaka milungu iwiri, uku akulamulira glycemia. Mwazi wamagazi panthawiyi uyenera kuchepa pang'onopang'ono. Masiku onse 10 mpaka 10, mlingo umakulitsidwa ndi 250-500 mg mpaka zolinga za shuga zitheke.

Kutalika kwa mankhwala

Ngati zikuwonetsedwa, nthawi ya chithandizo ndi Glucofage ndi yopanda malire. Pomwe mankhwalawa akugwira ntchito, muyenera kupitiliza kuumwa. Mukasiya kaye kwakanthawi, kuwonongeka kwa matenda ashuga kumachitika. Poyerekeza ndemanga za odwala, ndikotheka kukana mapiritsi osowa kwambiri, ngati wodwala yemwe ali ndi matenda oyamba omwe amadwala matenda ochepa a carb, amachita masewera olimbitsa thupi pafupipafupi ndipo amatha kuthana ndi kunenepa kwambiri. Ngati cholinga chofuna kudya chinali kutsika thupi, mutha kuletsa metformin mutangofika muyezo womwe mukufuna.

Mndandanda wa mankhwalawa, umawunikira za mtengo wake

Kugulitsidwa kwa Glucophage kuchokera ku matenda a shuga kungapangike ku malo aliwonse opanga mankhwala, malinga ngati wodwalayo ali ndi mankhwala omwe adalembedwa ndi adokotala. Mtengo wa mankhwalawa ku Russia umachokera pa 124 mpaka 340 rubles pa phukusi, kutengera dera lomwe lili mdzikolo.

Pambuyo poika ndi kugula mankhwala a Glucofage, malangizo ogwiritsira ntchito adzaphunzitsanso wodwalayo mwatsatanetsatane ndi katundu, zochita, zotsutsana ndi zotsatirapo za mankhwala.

Glucophage amalembedwa kwa anthu omwe apezeka ndi matenda a shuga a 2. Matendawa ndi chifukwa chakuchepa kwa chidwi cha minyewa pakuchitanso insulin, yopangidwa ndi thupi lokwanira komanso kuchuluka. Kuti thupi likhale labwinobwino, wodwalayo amapatsidwa chithandizo, chomwe chimaphatikizapo kumwa mankhwala omwe amalimbikitsa chidwi cha maselo kuti apatsidwe insulini, kuchepetsa kuchepa kwa shuga m'matumbo am'mimba.

Asanayambe mankhwala osokoneza bongo, wodwalayo adayikiridwa kuti adye zakudya zomwe zimapangitsa kuti achepetse kulemera kwathunthu ndikukula kwa kagayidwe kazakudya. Nthawi zambiri izi zimabweretsa thupi kukhala labwinobwino, koma anthu ena amayamba kuvutika ndi kutopa kwa kapamba, yemwe amachititsa kuti timadzi timene timapanga. Zotsatira zake, kupanga mahomoni achilengedwe kuyimitsidwa kwathunthu, ndipo wodwalayo sangathenso kuchita popanda jakisoni wa insulin.

Aliyense amadziwa kuti vuto lalikulu la odwala omwe ali ndi matenda a shuga ndikuwonjezereka msanga, ndipo pamapeto pake kunenepa kwambiri. Mukakhala kuti mukulemera kwambiri kuti mapiritsi a Glucofage ndi amodzi othandiza kwambiri. Kuchita kwawo ndikulinganiza kubwezeretsa kagayidwe ka lipid, kuletsa kuwonongeka kwa mafuta omwe amalowa mthupi kudzera mu chakudya, kuphatikiza shuga ndi magazi, komanso kuchepetsa chidwi chofuna kusintha kwa insulin.

Ndi chifukwa cha izi kuti pali milandu yambiri yowonjezereka yogwiritsa ntchito Glucofage ndi anthu athanzi omwe akuyesera kuti achepetse thupi. Izi zimachitika chifukwa cha mphamvu ina ya mankhwalawa - kuchepa kwa shuga wamagazi. Zotsatira zake, shuga amalowa mwachindunji m'matumbo, pomwe amawotcha kwathunthu, amakuphatikizira oxidation wamafuta achilengedwe ndikuchepetsa pang'onopang'ono pakuyamwa kwa zakudya zamafuta. Zotsatira zake zonse ndi kuchepetsedwa kwa kufalikira ndi kuchuluka kwa maselo amafuta.

Zochita zofooka

Ndi matenda a shuga, mlingo wosaposa 2000 mg ndi wabwino. Kusinthana ndi kuchuluka kwa mlingo kumawonjezera chiopsezo cha mavuto, koma pang'ono pa glycemia. Kuchulukanso kwina kwa mankhwalawa sikuthandiza komanso kupundana ndi lactic acidosis.

Mlingo wosinthidwa ukhoza kuchuluka pakapita nthawi. Izi sizikusonyeza kusuta, koma kusintha kwa matendawo kukhala gawo lina. Ndi shuga wambiri, kapamba amatuluka msanga, ndi metformin, muyenera kumwa mapiritsi owonjezera a shuga, kenako ndi insulin. Kuti muchepetse kaphatikizidwe ka insulin yanu, muyenera kutsatira mosamala chithandizo chomwe mumalandira, kuphatikizapo masewera ndi zakudya.

Mtundu, zikuchokera ndi gulu la mankhwala

Glucophage imapezeka mu mawonekedwe a mapiritsi oyera a biconvex pakamwa. Chithandizo chogwira mankhwalawa ndi metformin hydrochloride, zotulutsa ndi povidone ndi magnesium stearate. Mapiritsiwo amayikidwa mchimake cha filimu ya hypromellose.

Pogulitsa, mankhwalawa amapezeka m'mabokosi a makatoni. Mapaketi osiyanasiyana amatha kukhala ndi matuza a pulasitiki a mapiritsi 10, 15 ndi 20. Kutengera kuchuluka kwa zomwe zimagwira, mapiritsi amagawidwa mu Glucofage 500, Glucofage 850 ndi Glucofage 1000.

Mankhwalawa atalowa mthupi, njira yoyamwa ya m'mimba imachitika, ziyenera kukumbukiridwa kuti kudya kwambiri kumachepetsa. Kuphatikizika kwakukulu kwa metformin kumachitika maola a 2,5 atamwa, pomwe 60% yazinthu zonse zomwe zimagwira.Izi zili choncho chifukwa chakuti kumwa mapiritsi kumalimbikitsa. Mankhwala amathandizidwa ndi impso komanso m'mimba.

Pambuyo pakulowa m'thupi, metformin imalowa m'magazi, komwe imamangilira ma cell ofiira am'magazi, nthawi yomweyo pamakhala gawo lotsika loti lipangidwe ndi mapuloteni a plasma.

Kutulutsa mafomu ndi kapangidwe kake

Mankhwala ali ngati mawonekedwe a mapiritsi ozungulira pakamwa. Amakutidwa ndi chipolopolo choyera. Mapiritsi amatsekedwa mu ma contour cell - 20 ma PC aliyense. m'modzi aliyense. Atatu mwa maselowa ali m'matumba okhala ndi makatoni, omwe amaperekedwa m'mafakisi.

Mapiritsiwo ali ndi zigawo zingapo, zomwe zimagwira ntchito zomwe ndi metformin hydrochloride. Glucofage 500 ya zinthu iyi ili ndi 500 mg. Zothandiza zothandizira ndi povidone ndi magnesium stearate. Amathandizira kuchiritsa kwa mankhwalawa.

Kuchepetsa thupi

Mukamagwiritsa ntchito Glucofage 500 kuti muchepetse thupi, muyenera kumwa piritsi limodzi 1 nthawi patsiku kwa masiku 3-5. Ngati mankhwalawa amalekeredwa bwino, ndiye kuti mlingo umaloledwa kuwonjezeka mpaka 1000 mg patsiku. Koma izi zimaloledwa kwa odwala okha omwe kulemera kwawo kupitilira muyeso wopitilira 20 kg.

Mankhwalawa amatha milungu itatu. Pambuyo pa izi, yopuma ya miyezi iwiri imafunika. Ngati maphunziro oyamba sanapereke zovuta, ndiye kuti amaloledwa kuwonjezera Mlingo wachiwiri. Koma simungathe kutenga zoposa 2000 mg patsiku. Kuchuluka kwake kumagawidwa 2 times. The pakati pakati Mlingo ndi 8 maola kapena kupitirira.

Munthawi ya mankhwalawa, ndikofunikira kumwa madzi ambiri kuti mupewe mavuto: mankhwalawa amathandiza impso kuti zichotse msanga zopweteka za mankhwala.

Kukonzanso zakudya

Mapiritsi a Glucophage amagwira ntchito limodzi kuphatikiza ndi zakudya. Anthu odwala matenda ashuga nthawi zonse amakhala ochepetsedwa ndi chakudya pang'ono komanso osakhalitsa othamanga. Chiwerengero cha shuga pang'onopang'ono chololedwa tsiku lililonse chimatsimikiziridwa ndi adokotala. Zakudya zochepetsetsa kwambiri, zimalola mafuta okwana 300 g patsiku. Zovuta kwambiri ndizopendekera zotsika kwambiri zomwe zimakhala ndi malire mpaka 100 g ndi pansi. Mulimonsemo, chakudya chimayenera kukhala chamagulu azakudya zomanga thupi komanso zobiriwira. Chakudya chimayenera kudyedwa nthawi 5-6, zakudya zimagawidwa chimodzimodzi tsiku lonse.