Orlistat (Orlistat)

Munkhaniyi, mutha kuwerengera malangizo ogwiritsira ntchito mankhwalawa Orlistat. Amapereka ndemanga kuchokera kwa alendo omwe amabwera patsamba lino - ogwiritsa ntchito mankhwalawa, komanso malingaliro a akatswiri azachipatala pakugwiritsa ntchito Orlistat machitidwe awo. Chopempha chachikulu ndikuti muwonjezere ndemanga zanu za mankhwalawa: mankhwalawo adathandizira kapena sanathandizire kuchotsa matendawa, ndizovuta ziti zomwe zimawoneka ndi zotsatirapo zake, zomwe mwina sizinalengezedwe ndi wopanga. Ma Analogs a Orlistat pamakhala ma analogues omwe amapezeka. Gwiritsani ntchito mankhwalawa kunenepa kwambiri, kuchepa thupi komanso kuchepa thupi kwa anthu akuluakulu, ana, komanso pa nthawi ya bere. The zikuchokera mankhwala.

Orlistat - lipase inhibitor. Mukamamwa pakamwa, orlistat imalepheretsa chapamimba ndi kapamba. Zotsatira zake, kuwonongeka kwa mafuta azakudya kumasokonekera ndipo kuyamwa kwawo kuchokera m'mimba kumachepetsedwa. Ndi kugwiritsa ntchito mwadongosolo, izi zimapangitsa kutsika kwa thupi mwa odwala omwe ali ndi kunenepa kwambiri. Orlistat sikuti imangomizidwa m'matumbo am'mimba motero alibe mphamvu iliyonse.

Kupanga

Omwe amachokera ku Orlistat.

Pharmacokinetics

Odzipereka omwe ali ndi thupi lozama komanso kunenepa kwambiri, zomwe zimapangitsa mankhwalawa ndizochepa. Pambuyo pakamwa kamodzi pakumwa mankhwala osokoneza bongo a 360 mg, orlistat yosasinthika mu plasma sinathe kutsimikizika, zomwe zikutanthauza kuti mayikidwe ake ali pansi pa 5 ng / ml. Panalibe zizindikiritso, zomwe zimatsimikizira kuti kuyamwa kwa mankhwalawo ndizochepa. Pochulukirapo, orlistat imatha kulowa m'magazi ofiira. Poyerekeza ndi zomwe zapezedwa poyesera nyama, kagayidwe ka orlistat kamachitika makamaka m'mimba mwa matumbo. Kafukufuku mwa anthu omwe ali ndi vuto labwinobwino komanso onenepa kwambiri awonetsa kuti njira yayikulu yochotsera ndikuchotsa mankhwalawa omwe sangatengeke ndi ndowe. Ndi ndowe, pafupifupi 97% ya mlingo wovomerezeka wa mankhwalawa adachotsedwa, ndi 83% mu mawonekedwe a orlistat osasinthika. Kutupa kwathunthu kwa impso pazinthu zonse zomwe zimapangidwa ndi orlistat ndizochepera 2% ya mlingo wotengedwa. Nthawi yoti mumalize kuthetsa mankhwalawa m'thupi (ndowe ndi mkodzo) ndi masiku 3-5.

Zizindikiro

• kunenepa kwambiri (kuphatikiza ndi zakudya zopatsa mphamvu zopatsa mphamvu).

Kutulutsa Mafomu

Makapisozi 120 mg (nthawi zina amatchedwa mapiritsi molakwika).

Malangizo ogwiritsira ntchito ndi regimen

Imwani mankhwalawa 120 mg pakudya kali konse kapena mkati mwa ola limodzi mutatha kudya, nthawi zambiri osapitirira katatu pa tsiku. Ngati chakudya chanu ndichoperewera, mutha kudumpha orlistat.

Zotsatira zoyipa

• Kutulutsa kwamafuta kuchokera ku rectum,
• chisangalalo
• kusintha kwa mpweya ndi zotulutsa zina
• ukufalikira
• chopondapo mafuta:
• pafupipafupi matumbo
• chilimbikitso chofuna kunyoza,
• fecal kulephera.

Contraindication

• aakulu malabsorption syndrome,
• cholestasis
• Hypersensitivity to Orlistat.

Mimba komanso kuyamwa

Orlistat imagwiritsidwa ntchito mosamala kwambiri panthawi yoyembekezera komanso mkaka wa m'mawere.

Pophunzira za poizoni mu nyama, teratogenic ndi embryotoxic zotsatira za mankhwala sizinachitike. Pokhapokha ngati teratogenic zotsatira mu nyama, zofanana mu anthu sayenera kuyembekezera.

Gwiritsani ntchito ana

Malangizo apadera

Tiyenera kukumbukira kuti pafupipafupi komanso kuopsa kwa mavuto amakula ndikuwonjezera mafuta m'zakudya. Ndi kuchepa kwamafuta m'zakudya, zovuta zake zoyipa zimachepa. Ndikulimbikitsidwa kuti kuchuluka kwa mafuta omwe amagwiritsidwa ntchito patsiku kumagawidwa mokwanira pazakudya zonse.

Mankhwala, pamene thupi limachepa, ndizotheka kusintha njira zama pathological zomwe nthawi zambiri zimagwirizanitsidwa ndi kunenepa, kuphatikiza ochepa matenda oopsa, matenda ashuga, matenda a lipid metabolism.

Kuyanjana kwa mankhwala

Orlistat yawonetsedwa kuti ikuchepetsa mayamwidwe am'mimba a betacarotene, alpha-tocopherol.

Panalibe kuyanjana ndi amitriptyline, atorvastatin, biguanides, digoxin, fibrate, fluoxetine, losartan, phenytoin, njira zakulera pakamwa, phentermine, pravastatin, warfarin, nifedipine GITS (dongosolo la mankhwala oledzera m'mimba) kapena nibbutin pakati pa mankhwala). Komabe, ndikofunikira kuyang'anira momwe MNO imagwirira ntchito ndi warfarin kapena anticoagulants pakamwa.

Ndi munthawi yomweyo makonzedwe a orlistat ndi antiepileptic, milandu ya kukomoka idawonedwa. Ubale wapakati pakati pa kukhazikika kwa khunyu ndi mankhwala a orlistat sunakhazikitsidwe. Komabe, odwala ayenera kuwunikidwa kuti azisintha pafupipafupi komanso / kapena kuopsa kwa matenda opatsirana.

Mndandanda wa mankhwala Orlistat

Zofanana muzochitika zamagulu:

• Allie
• Xenalten
• Kuwala kwa Xenalten,
• Xenalten Slim,
• Xenical
• Mndandanda
• Mndandanda wa Miniata,
• Orlimax
• Kuwala kwa Orlimax,
• Orlistat Canon
• Orsoten
• Orsotin Slim.

Analogs for the achire zotsatira (ndalama zochizira kunenepa):

• Aknekutan,
• Bacteria usawa
• Zakudya zomanga thupi
• Garcilin
• Garcinia forte
• Golidi
• Kutonthoza Zakudya
• Dietol compositum,
• Zakudya zamagetsi
• Zakudya zachilengedwe,
• Dr. Theiss Nova Chithunzi,
• Zabwino
• Coenzyme Q10 ndi Ginkgo,
• Lamisplat
• Lindax,
• Magnesium Complex,
• Meridia
• Metformin
• Mukofalk,
• Normoflorin
• Oxodoline,
• Orsoslim
• Reduxin
• Polysorb
• Sibutramine,
• Wofatsa,
• Slim Plus,
• Trimex,
• Phenotropil,
• Mkuyu
• Fitolaks,
• Phytomucil,
• Moyo wa Hoodia,
• Hoodia Slim
• Fomula ya Ziprimax Plus,
• Choprosept
• Shugafri.

Gulu la mankhwala

Mankhwala

A inhibitor yeniyeni ya m'mimba lipases. Amapanga mgwirizano wolumikizana ndi gawo loyeserera la serine m'matumbo ndi ma pancreatic lipases mu lumen pamimba ndi matumbo ochepa. Ma enzyme osayatsidwa amatha kutaya mafuta mu chakudya cha mtundu wa triglycerides (TG). Ma TG osagwiritsidwa ntchito samayamwa, ndipo kutsika kwa kashiamu kumabweretsa kuchepa kwa thupi. Amawonjezera kuchuluka kwa mafuta mu ndowe 24-48 maola atamwa. Amapereka kuyendetsa bwino kwa thupi, kuchepetsa mafuta malo.

Ngati chiwonetsero cha ntchito, kuyamwa kwa orlistat sikofunikira; pa mlingo woyenera wa mankhwala (120 mg katatu patsiku), umaletsa kuyamwa kwa mafuta omwe amapezeka ndi pafupifupi 30%.

Pharmacokinetics

Mafuta akumwa ndi ochepa, maola 8 atamwa, orlistat yosasinthika mu plasma sinatsimikizidwe (ndende pansipa 5 ng / ml).

Kuwonetsedwa mwadongosolo kwa orlistat ndizochepa. Pambuyo pakumeza kwa 360 mg ya radioactively yolembedwa 14 C-orlistat, chiwonetsero cha peresenti mu plasma chinafikiridwa patatha pafupifupi maola pafupifupi 8, kuzungulira kwa orlistat yosasinthika kunali pafupi ndi malire kuti adziwe (osakwana 5 ng / ml). M'maphunziro othandizira, omwe amaphatikiza kuyang'anira zitsanzo za plasma za odwala, orlistat yosasinthika idatsimikizika mopitilira muyeso m'magazi a plasma, ndipo magwiritsidwe ake anali otsika (osakwana 10 ng / ml), osakhala ndi zizindikiro zakudzikundikira, zomwe zimagwirizana ndi kuyamwa kochepa kwa mankhwalawa.

Mu vitro orlistat yoposa 99% imamangilira mapuloteni a plasma, makamaka okhala ndi lipoproteins ndi albumin. Orlistat imalowa m'magazi ofiira. Amapangidwa makamaka khoma la m'mimba thirakiti ndikupanga ma cellacologically osagwira metabolites M1 (hydrolyzed anayi lactone mphete) ndi M3 (M1 yokhala ndi zotsalira za N-formylleucine). Pakufufuza kwa odwala onenepa omwe adamwa 14 C-orlistat, 2 metabolites, M1 ndi M3, adawerengera pafupifupi 42% ya kuchuluka kwa madzi am'magazi. M1 ndi M3 ali ndi mphete ya beta-lactone yotseguka ndikuwonetsa ntchito yofooka kwambiri yolimbana ndi lipases (poyerekeza ndi orlistat, ali 1000 ndi 2500 nthawi zochepa, motsatana). Popeza ntchito yotsika komanso kuchepa kwa plasma metabolites (pafupifupi 26 ng / ml ndi 108 ng / ml ya M1 ndi M3, motsatana, maola 2-5 mutatha orlistat mu Mlingo wothandizira), ma metabolites awa amawonedwa ngati achuma. M1 metabolite yayikulu imakhala ndi T yochepa_1/2 (pafupifupi 3 maola), metabolite yachiwiri imachotsedwedwa pang'onopang'ono (T_1/2 - maola 13.5). Mu Odese Odwala C_ss metabolite M1 (koma osati M3) imawonjezeka molingana ndi mlingo wa orlistat. Pambuyo pakukonzekera kamodzi pamlomo kwa 360 mg ya 14 C-orlistat ndi odwala omwe ali ndi vuto lozolimbitsa thupi ndipo akuvutika ndi kunenepa kwambiri, kumasulidwa kwa orlistat yosagwiritsa ntchito m'matumbo inali njira yayikulu yotsatsira. Orlistat ndi metabolites ake M1 ndi M3 nawonso amathandizidwa ndi bile. Pafupifupi 97% ya zinthu zomwe zimalembedwa mothandizidwa ndi ma radio zimapezeka ndi ndowe, kuphatikiza 83% - osasinthika.

Kutupa kwathunthu kwa impso kwa radioactivity yonse ndi 360 mg ya 14 C-orlistat kunali kochepera 2%. Nthawi yakuchotsedwa kwathunthu ndi ndowe ndi mkodzo ndi masiku 3-5. Excretion ya orlistat idapezeka kuti ndi yofanana kwa odwala omwe ali ndi thupi lozama komanso kunenepa kwambiri. Kutengera ndi data zochepa, T_1/2 orlistat yodziwika bwino imachokera ku maola 1-2.

Zisonyezo za Orlistat ya mankhwala

Chithandizo cha kunenepa, kuphatikiza kuchepetsa ndi kukonza thupi, kuphatikiza zakudya zamagulu ochepa.

Kuchepetsa chiopsezo chopezanso kulemera kwa thupi pambuyo pakuchepa kwake koyamba.

Orlistat imawonetsedwa kwa odwala onenepa kwambiri omwe ali ndi index ya body mass (BMI) ya ≥30 kg / m 2 kapena ≥28 kg / m 2 pamaso pazinthu zina zowopsa (matenda ashuga, matenda oopsa, dyslipidemia). (Kuwerenga BMI: BMI = M / P 2, pomwe M - kulemera kwa thupi, kg, P - kutalika, m.)

Mimba komanso kuyamwa

Orlistat imatsutsana panthawi yomwe ali ndi pakati chifukwa chosowa deta yachipatala yodalirika yotsimikizira chitetezo chazomwe imagwiritsidwa ntchito.

Sizinakhazikitsidwe ngati orchidat imadutsa mkaka wa m'mawere, chifukwa chake kugwiritsa ntchito Xenalten ® panthawi yoyamwitsa sikulimbikitsidwa.

Zotsatira zoyipa

Pafupipafupi pazovuta zomwe zili pansipa zimatsimikiziridwa molingana ndi izi: nthawi zambiri (> 1/10), nthawi zambiri (> 1/100, 1/1000, 1/10000, GIT: Nthawi zambiri - Mafuta amadzimadzi kuchokera ku rectum, mpweya wokhala ndi zotulutsa zina, kufunikira kodzikuza, kuwotcha, kuyenda matumbo pafupipafupi, mapando otayirira, kukhumudwa, kupweteka kapena kusasangalala pamimba.

Monga lamulo, izi zoyipa zimachitika yofatsa komanso yochepa, zimachitika m'magawo oyambira (mu miyezi 3 yoyambirira). Pafupipafupi izi zimachitika ndikutulutsa mafuta ochulukirapo m'zakudya. Odwala ayenera kudziwitsidwa za kuthekera kwa kukhalapo kwa izi zoyipa ndikuti aphunzitsidwe momwe angazichotsere pakudya bwino, makamaka poyerekeza kuchuluka kwa mafuta omwe amapezeka. Nthawi zambiri - zofewa, kupweteka kapena kusapeza bwino mu rectum, fecal incontinence, bloating, dzino kuwonongeka, matenda a chingamu.

Kuchokera pakapumidwe, m'chifuwa ndi ziwalo zam'mimba: kwambiri kupuma thirakiti matenda, nthawi zambiri m'munsi kupuma thirakiti matenda.

Kuchokera ku chitetezo chamthupi: kawirikawiri - kuyabwa, urticaria, zidzolo, angioedema, bronchospasm, anaphylaxis.

Kuchokera ku dongosolo lamanjenje: nthawi zambiri - kupweteka mutu.

Pa mbali ya chiwindi ndi biliary thirakiti: kawirikawiri - kuchuluka kwa transaminases ndi zamchere phosphatase, hepatitis.

Kuchokera ku impso ndi kwamkodzo thirakiti: Nthawi zambiri kwamikodzo thirakiti matenda.

Zina: pafupipafupi - chimfine, nthawi zambiri - dysmenorrhea, nkhawa, kufooka.

Ngati mavuto aliwonse omwe atchulidwa mu malangizowo adakulirakulira kapena mavuto ena omwe sanatchulidwe mu malangizo awonedwa, muyenera kudziwitsa dokotala.

Kuchita

Orlistat sichikhudzanso pharmacokinetics ya ethanol, digoxin (yodziwika mu mlingo umodzi) ndi phenytoin (zotchulidwa muyezo umodzi wa 300 mg), kapena bioavailability wa nifedipine (mapiritsi olanditsidwa otulutsidwa). Ethanol sikukhudza pharmacodynamics (mafuta am'mimbamo okhala ndi ndowe) komanso mawonekedwe a orlistat mwadongosolo.

Pogwiritsa ntchito munthawi yomweyo orchidat ndi cyclosporine, gawo lotsiriza la plasma limatsika (orlistat ndi cyclosporine sayenera kumwedwa panthawi imodzimodzi, kuti muchepetse kugwiritsidwa ntchito kwa mankhwala, cyclosporine iyenera kutengedwa maola 2 asanafike kapena maola awiri mutatha kumwa orlistat.

Pogwiritsa ntchito munthawi yomweyo warfarin kapena anticoagulants ena osagwirizana ndi orlistat, kuchuluka kwa prothrombin kungachepe ndipo phindu la chidziwitso cha INR lingasinthe, kotero kuwunika kwa INR ndikofunikira. Orlistat imachepetsa kuyamwa kwa beta-carotene mu zakudya zowonjezera ndi 30% ndipo imalepheretsa kuyamwa kwa vitamini E (mu mawonekedwe a tocopherol acetate) ndi pafupifupi 60%.

Iwo kumawonjezera bioavailability ndi hypolipidemic zotsatira za pravastatin, kuwonjezera ndende yake mu plasma ndi 30%.

Ndi makonzedwe munthawi yomweyo ndi orlistat, kuyamwa kwa mavitamini A, D, E ndi K kumachepetsedwa. Ngati multivitamini amalimbikitsidwa, ayenera kumwedwa osachepera maola 2 mutatha Xenalten ® kapena musanagone.

Kuchepetsa thupi kumatha kukonza kagayidwe kachakudya kwa odwala matenda a shuga, chifukwa chake ndikofunikira kuchepetsa kuchuluka kwa mankhwala am'mlomo a hypoglycemic.

Kugwiritsira ntchito nthawi yomweyo kwa acarbose sikulimbikitsidwa chifukwa chakuchepa kwa data pamayendedwe a pharmacokinetic. Pogwiritsa ntchito munthawi yomweyo ndi orlistat, kuchepa kwa mlingo wa amiodarone mu plasma pambuyo podziwika kamodzi. Kugwiritsa ntchito nthawi yomweyo kwa orlistat ndi amiodarone kumatheka pokhapokha ngati dokotala akuwalimbikitsa.

Orlistat imatha kuchepetsa bioavailability ya kulera kwapakamwa, yomwe ingayambitse kutenga pakati posakonzekera. Ndikulimbikitsidwa kugwiritsa ntchito mitundu ina ya njira zakulera pobayira m'mimba.

Zokhudzana mwadongosolo kwambiri ndi digoxin, amitriptyline, phenytoin, fluoxetine, sibutramine, atorvastatin, pravastatin, losartan, glibenclamide, kulera kwapakamwa, nifedipine, furosemide, capopril, atenolol ndi ethanol sizinadziwike.

Bongo

Milandu ya mankhwala osokoneza bongo sichinafotokozedwe.

Mlingo umodzi wa 800 mg wa orlistat kapena Mlingo wambiri mpaka 400 mg katatu pa tsiku kwa masiku 15 ndi anthu omwe ali ndi thupi labwino komanso kunenepa kwambiri sizinachitike ndi zovuta zina.

Ngati mankhwala osokoneza bongo atapezeka, wodwalayo ayenera kuyang'aniridwa kwa maola 24. Malinga ndi kafukufuku wa nyama ndi anthu, zovuta zomwe zimagwirizana ndi lipase-inhibiting katundu wa orlistat ziyenera kusinthidwa mwachangu.

Malangizo apadera

Munthawi yamankhwala, ndikofunikira kutsatira zakudya zopatsa thanzi, zopatsa mphamvu zochepa zopatsa mphamvu zopitilira 30% mu mafuta ndi kupatsidwa zipatso ndi ndiwo zamasamba.

Musanapereke mankhwala a orlistat, zomwe zimayambitsa kunenepa kwambiri, monga hypothyroidism, ziyenera kulembedwa.

Kuwonongeka kwa zotsatira zoyipa kuchokera m'matumbo am'mimba kumawonjezeka ndi mafuta ambiri mu chakudya (zoposa 30% ya zopatsa mphamvu tsiku ndi tsiku). Zakudya za tsiku ndi tsiku za mafuta, chakudya komanso mapuloteni ziyenera kugawidwa pakati pazakudya zitatu zazikuluzikulu. Popeza orlistat imachepetsa mayamwidwe mavitamini ena osungunuka, odwala ayenera kutenga makonzedwe a multivitamin okhala ndi mavitamini osungunuka a mafuta kuti atsimikizire kuchuluka kwawo. Kuphatikiza apo, zomwe zili ndi mavitamini D ndi beta-carotene mwa odwala onenepa kwambiri zitha kutsika kuposa anthu omwe si onenepa kwambiri. Ma multivitamini amayenera kumwedwa ma 2 maola asanafike kapena maola awiri mutatha kumwa orlistat, mwachitsanzo, musanagone. Odwala omwe sanalandire prophylactic vitamini zowonjezera, pakapita maulendo awiri kapena angapo motsatizana kwa dokotala mkati mwa zaka zoyambirira ndi zachiwiri zamankhwala ndi orlistat, kuchepa kwa kuchuluka kwa mavitamini mu plasma kunalembedwa. Popeza mayamwidwe a Vitamini K akamatenga orlistat amatha kuchepa, odwala omwe amalandila orlistat motsutsana ndi maziko a nthawi yayitali ya warfarin, magawo a coagulation wamagazi amayenera kuyang'aniridwa.

Kulandila kwa orlistat mu Mlingo wopitilira 120 mg katatu patsiku sikuthandizira zowonjezera.

Ngati kuphatikiza ndi munthawi yomweyo orchidat yokhala ndi cyclosporine sikungapeweke, kuyang'anira zochitika za cyclosporin mu plasma ndikofunikira.

Odwala ena, motsutsana ndi orchidat, zomwe zili mu oxalates mu mkodzo zimatha kuchuluka. Monga ndimankhwala ena ochepetsa thupi, m'magulu ena a odwala (mwachitsanzo, anorexia manthaosa kapena bulimia), pali mwayi wovutitsidwa ndi orlistat.

Orlistat kuphatikizidwa kwa kuchepa thupi kumatha kuphatikizidwa ndi kusintha kwa kagayidwe kachakudya ka shuga. Ngati, pambuyo pa milungu 12 yochizira ndi Xenalten ®, kuchepa kwa thupi kunali kosakwana 5% ya koyambirira, dokotala amayenera kuthandizidwa kuti adziwe ngati apitiliza kulandira chithandizo ndi orlistat.

Kuchiza sikuyenera kupitilira zaka 2.

Xenalten ® sanapangidwe kuti adzagwiritse ntchito ana.

Kukopa pa kuyendetsa magalimoto ndi kayendedwe kosuntha. Siziwononga kuthekera koyendetsa magalimoto ndikukhala ndi makina oyenda.

Malangizo ogwiritsira ntchito Orlistat, mlingo

Makapisozi amatengedwa pakamwa pakudya, kutsukidwa ndi madzi. Malangizo ogwiritsira ntchito Orlistat amalimbikitsa kumwa mankhwalawa katatu patsiku, pachakudya chilichonse.

Ngati chakudya mulibe mafuta, mutha kudumphira kumwa mankhwalawo.

Malangizo apadera

Kuti muwonetsetse kuti zakumwa zonse zakudya zimafunikiridwa, imalimbikitsidwa kumwa ma multivitamini ambiri (imwani 2 maola mutamwa mankhwalawo kapena pogona).

Wodwala amayenera kulimbikitsidwa kuti azikhala ndi zakudya zamafuta ochepa, chifukwa kufalikira kwa m'mimba kumatha kuchuluka ngati Orlistat atengedwa mukudya zakudya zamafuta ambiri (mwachitsanzo, 2000 kcal / tsiku, omwe oposa 30% ali mu mawonekedwe a mafuta, omwe amafanana ndi 67 g )

Zotsatira zoyipa

Malangizowa amachenjeza za mwayi wokhala ndi zotsatirapo zoyipa mukamapereka Orlistat:

• Kutulutsa kwamafuta kuchokera ku rectum,
• Zachisangalalo
• Kutulutsa kwamagesi ndi zotulutsa zina,
• Kufalikira
• Steatorrhea
• Kuyenda kwamatumbo pafupipafupi
• Kulakalaka kopanda chilungamo,
• Fecal kulephera.

Contraindication

Orlistat imatsutsana pazochitika zotsatirazi:

• Cholestasis
• Malabsorption syndrome,
• Osakwana zaka 18
• Mimba ndi kuyamwitsa,
• Ntchito mogwirizana ndi cyclosporine,
• Hypersensitivity pazinthu zilizonse za mankhwala.

Fotokozerani mosamala:

• Nephrolithiasis (kukhalapo kwa miyala ya calcium oxalate),
• Mbiri ya hyperoxaluria.

Bongo

Mankhwala osokoneza bongo, monga lamulo, amawonetsedwa ndi zotsatira zoyipa kuchokera m'mimba. Ndikofunikira kuyang'ana momwe wodwalayo alili, chithandizo chamankhwala.

Ma Analogs a Orlistat, mtengo pama pharmacies

Ngati ndi kotheka, m'malo mwa Orlistat, izi zitha kuchitika ndi analogue yogwira - mankhwala:

Mukamasankha analogues, ndikofunikira kumvetsetsa kuti malangizo ogwiritsira ntchito Orlistat, mtengo ndi zowunikira sizikugwira ntchito ndi mankhwalawa ofanana. Ndikofunikira kupeza upangiri wa dokotala komanso kuti usasinthe popanda mankhwala.

Mtengo m'mafakitoreti aku Russia: Orlistat 60 mg 42 makapisozi - kuchokera 430 mpaka 550 rubles, 120 mg 42 makapisozi - kuchokera pa 1048 mpaka 1200 rubles, malinga ndi ma pharmacies a 793.

Pewani patali ndi ana, mutetezedwe ku kuwala ndi chinyezi, kutentha osapitirira 25 ° C. Moyo wa alumali ndi zaka 2.

Zoyenera kufalitsa kuchokera ku mafakitala zimalembedwa ndi mankhwala.

Ndemanga 4 za "Orlistat"

Anatenga theka la chaka Orlistat. Munthawi imeneyi, adataya 28 kg. Poyamba ndimazunzidwa ndi ndowe zamadzimadzi, kenako ndidalekerera mankhwalawa mwachizolowezi. Pofuna kuchepetsa thupi moyenera, mwachidziwikire, ndidatsata chakudya. Patsiku - zosaposa 1200 kcal.

Ngati simukudya mafuta, ndiye kuti simufunikira mankhwalawa. Sadzachotsa mafuta anu, amachotsa zomwe zidyedwa.

Ndachepa thupi, ndipo kwambiri. Mwezi woyamba uli pafupifupi 8kg ... ndiye pafupifupi 5 ... sindinanama mu gramu ndipo sindinawerenge masiku. Chachikulu ndikulolera sabata yoyamba ndikudya mavitamini.

Kutulutsa mawonekedwe ndi kapangidwe kake

Mankhwalawa amapangidwa mwanjira ya makapisozi: kukula No. 1, gelatin yolimba, thupi ndi chivindikiro ndi mtundu wa buluu, zomwe zimapezeka m'mabotolo ndizovala zoyera kapena zoyera (ma PC 7 kapena 21. M'matumba, pamatumba a makatoni 1, 2, 3, 4, 6 , Mapaketi 12).

1 kapisozi muli:

• yogwira mankhwala: orlistat - 120 mg,
• zina zowonjezera: sodium carboxymethyl wowuma (sodium starch glycolate), cellcosestalline cellulose, povidone, talc, sodium lauryl sulfate,
• chipolopolo: titanium dioxide (E171), gelatin, utoto wa utoto.

Zizindikiro zogwiritsidwa ntchito

• Chithandizo cha kunenepa kwambiri, kuphatikiza kuonetsetsa kuchepetsa ndi kukonza thupi, kuphatikiza zakudya zamagulu ochepa.
• kuchepetsa kuopseza kukonzanso thupi pambuyo pakuchepa kwake koyamba.

Mankhwalawa amalimbikitsidwa kwa odwala onenepa kwambiri omwe ali ndi index ya misa (BMI) ≥ 30 kg / m² kapena odwala omwe ali ndi BMI ≥ 28 kg / m obes pamaso pa zinthu zomwe zimayambitsa kunenepa kwambiri monga matenda oopsa, matenda oopsa a dyslipidemia, ndi matenda a shuga.

Kuwerengera kwa BMI kumachitika malinga ndi njira yotsatira: M (M - kulemera kwa thupi mu kg) / P 2 (P - kutalika mu m).

Contraindication

• cholestasis
• malabsorption syndrome,
• wazaka 18
• mimba ndi kuyamwitsa,
• ntchito ndi cyclosporine,
• Hypersensitivity ku zilizonse za mankhwala.

Wachibale (gwiritsani ntchito mosamala):

• nephrolithiasis (kukhalapo kwa miyala ya calcium oxalate),
• mbiri ya hyperoxaluria.

Mimba komanso kuyamwa

Pa nthawi yoyembekezera, kutenga Orlistat kumatsutsana, chifukwa palibe deta yodalirika yazachipatala yotsimikizira kutetezeka kwa kugwiritsidwa ntchito kwake kwa amayi apakati.

Sizikudziwika ngati mankhwalawa amuchotsa mkaka waumunthu, motero amakanizidwa kuti amwe mankhwalawa panthawi yoyamwa.

Kuyanjana kwa mankhwala

• phenytoin, amitriptyline, digoxin, sibutramine, fluoxetine, losartan, pravastatin, atorvastatin, pakamwa kulera, glibenclamide, furosemide, nifedipine, ethanol, atenolol, capopril - palibe zochitika zamankhwala zofunika kudziwa
• ethanol, phenytoin (pa mlingo wa 300 mg), digoxin (wogwiritsidwa ntchito mu mlingo umodzi) - pharmacokinetics yazinthu izi sizisintha, mphamvu ya ethanol pakuwonekera kwantchito ndi pharmacodynamics (kuchuluka kwa mafuta okhala ndi ndowe) ya orlistat sikunachitike,
• nifedipine (mawonekedwe a mapiritsi otulutsidwa) - kukhudzana kwa mankhwalawa sikusintha,
• cyclosporin - kuchuluka kwake kwa plasma kumachepa, simuyenera kumwa mankhwalawa nthawi yomweyo, ngati kuli kotheka, kugwiritsa ntchito pamodzi kwa cyclosporine ndikulimbikitsidwa kugwiritsidwa ntchito maola 2 musanayambe kapena mutatha kumwa orlistat (kuwunikira pafupipafupi kuchuluka kwa cyclosporine mu plasma ndikofunikira),
• acarbose - palibe data pakukhudzana kwa pharmacokinetic, kugwiritsa ntchito nthawi yomweyo sikulimbikitsidwa,
• amiodarone - ndi kuphatikiza uku, kuchepa kwa zinthu zam'madzi za amiodarone kumadziwika, mlingo wophatikizana ndi orlistat umatheka pokhapokha ngati akuwongolera dokotala,
• anticoagulants osaphatikizidwa (kuphatikizapo warfarin) - ndizotheka kuchepetsa kuchuluka kwa prothrombin ndikusintha mtengo wa chizindikiro cha kuchuluka kwa mayiko wamba (INR), chifukwa cha izi, kuyang'anira INR ndikofunikira
• beta-carotene - mayamwidwe ake amachepetsa 30%,
• pravastatin - imawonjezera plasma ndende ya zinthuzi (pofika 30%) ndi bioavailability, zomwe zimabweretsa kuchuluka kwa lipid-kutsitsa,
• Vitamini E (mu mawonekedwe a tocopherol acetate) - mayamwidwe ake amachepetsedwa pafupifupi 60%,
• mankhwala antidiabetesic mankhwala (sulfonylurea / metformin zotumphukira), insulin - zingakhale zofunikira kuchepetsa kuchuluka kwa mankhwalawa chifukwa cha kusintha kwa kagayidwe kachakudya kwa odwala matenda a shuga.
• kulera kwapakamwa - ndikotheka kuti achepetse kubereka kwawo (chifukwa chosakhudzidwa ndi orlistat), motsutsana ndi maziko am'mimba opweteka kwambiri, tikulimbikitsidwa kugwiritsa ntchito njira zina zakulera.

Zofanizira za Orlistat ndi: Listata Mini, Orsoten, Listata, Xenalten Slim, Orsoten Slim, Xenical, Xenalten Logo, Orliksen 120, Orliksen 60, Alli, Xenalten Light.

Ndemanga ya Orlistat

Odwala omwe amamwa mankhwalawo amapita ku ndemanga zabwino za Orlistat. Ambiri amati atatha kuphunzira chithandizo adatha kuchepetsa kwambiri thupi, pomwe palibe mawonekedwe apadera amtundu wa mankhwala. Mankhwala, malinga ndi mawunikidwe, amagwira ntchito pang'onopang'ono koma molimbika, amakulolani kuchepa 10 makilogalamu kulemera pafupifupi miyezi isanu ndi umodzi. Odwala amalimbikitsanso kuti munthawi ya chithandizo, onetsetsani kusintha momwe mumadyera ndikusankha pulogalamu yoyenera yolimbana ndi kunenepa moyang'aniridwa ndi katswiri wazodziwa.

Komabe, palinso ndemanga za odwala osakhutira, zomwe zimawonetsa kusakwanira kwa mankhwalawo kapena kusapezeka kwathunthu pazotsatira zabwino. Palinso madandaulo angapo onena za kukhazikika kwa zotsatira zoyipa za orlistat, monga lamulo, mu mawonekedwe a kusakhazikika kwa m'mimba, kusanja, kuwumba kosasunthika, komanso kufooka kwambiri. Zimadziwika kuti kumachitika kawirikawiri pazovuta zina zomwe zapangitsa kuti mankhwalawa asiye.