Protamine insulin mwadzidzidzi: malangizo ogwiritsa ntchito ndi kuwunika

Ngati muli ndi pakati kapena mukukonzekera kutenga pakati, muyenera kufunsa dokotala kuti akuuzeni kuchuluka kwa insulin yomwe ingafunike kuti muchepetse shuga komanso kupewa hyperglycemia (shuga wambiri wamagazi) ndi hypoglycemia (shuga wochepa kwambiri wamagazi), chifukwa zonsezi kuvulaza mwana wanu wosabadwa. Kuyamwitsa panthawi ya mankhwala a insulin sikuyambitsa ngozi kwa mwana wanu. Komabe, ndizotheka kuti mlingo wa insulini ndi zakudya uyenera kusintha.

Mlingo ndi makonzedwe

ES protamine-insulin imapangidwira makonzedwe a subcutaneous. Mankhwala sangathe kutumikiridwa kudzera m'mitsempha.

Mlingo wa mankhwalawa umatsimikiziridwa ndi dokotala aliyense payekhapayekha malinga ndi kuchuluka kwa shuga m'magazi. Pafupifupi, tsiku lililonse mlingo wa mankhwalawa umachokera ku 0,5 mpaka 1 IU / kg thupi, kutengera mtundu wa wodwalayo komanso kuchuluka kwa shuga.

Kutentha kwa insulin yoyenera kuyenera kukhala kutentha kwambiri.

ES protamine-insulin nthawi zambiri amabailidwa mosatentheka mu ntchafu. Mankhwalawa akapaka kulowetsedwa mosunthira m'chiuno, mankhwalawa amawamwa pang'onopang'ono komanso moyenera kuposa momwe amapaka jekeseni malo ena.

Zilonda zitha kupangidwanso m'chigawo cha minofu ya m'mapewa.

Kupanga jakisoni pakhungu kumachepetsa chiopsezo cholowera minofu. Ndikofunikira kusintha malo a jekeseni mkati mwa anatomical dera kuti muchepetse kukula kwa lipodystrophy.

Pogwiritsa ntchito insulin kwambiri, chitetezo cha Protamine-Insulin Emergency chitha kugwiritsidwa ntchito ngati basal insulin nthawi 1-2 patsiku (madzulo ndi / kapena makonzedwe a m'mawa) osakanikirana ndi insulin yochepa, yomwe imayendetsedwa musanadye.

Mtundu wachiwiri wa matenda a shuga, matenda a Protamine-Insulin Emergency amatha kugwiritsidwa ntchito limodzi ndi mankhwala a hypoglycemic omwe amatengedwa pakamwa pomwe anthu sangadzipetse okha matenda a shuga.

Zotsatira za pharmacological

Kutalika kwapakati pa insulin yaumunthu yomwe imagwiritsidwa ntchito pogwiritsa ntchito ukadaulo wa DNA. Imalumikizana ndi cholandirira chapadera pa cell ya cytoplasmic maselo ndikupanga insulini-receptor zovuta zomwe zimapangitsanso njira zina, kuphatikizapo

kaphatikizidwe angapo ofunikira a michere (hexokinase, pyruvate kinase, glycogen synthetase). Kutsika kwa glucose m'magazi kumachitika chifukwa cha kuchuluka kwa kayendedwe kazinthu zosafunikira, kuchuluka kwa mayamwa komanso kusokonekera kwa minofu, kukondoweza kwa lipogenesis, glycogenogeneis, ndi kuchepa kwa kuchuluka kwa shuga m'magazi.

Kutalika kwa nthawi ya kukonzekera kwa insulin kumachitika makamaka chifukwa cha kuchuluka kwa mayamwidwe, zomwe zimatengera zinthu zingapo (mwachitsanzo, pa mlingo, njira ndi malo oyang'anira), chifukwa chake zochitika za insulin zimasinthasintha kwambiri, mwa anthu osiyanasiyana komanso chimodzimodzi munthu.

Pafupifupi, pambuyo pa utsogoleri wa sc, insulin iyi imayamba kugwira ntchito pambuyo maola 1.5, kutalika kokwanira kumakhala pakati pa maola 4 ndi maola 12, nthawi yayitali mpaka maola 24.

Pharmacokinetics

Kukwanira kwathunthu ndi kuyambika kwa mphamvu ya insulin kumadalira malo a jakisoni (m'mimba, ntchafu, matako), mlingo (kuchuluka kwa insulin), komanso kuchuluka kwa insulin pokonzekera.

Imagawidwa mosiyanasiyana munsiyo, simalowerera chotchinga ndi mkaka wa m'mawere. Amawonongedwa ndi insulinase makamaka m'chiwindi ndi impso. Amachotsa impso (30-80%).

Type 1 shuga mellitus, mtundu 2 shuga mellitus: gawo la kukana kwamlomo hypoglycemic wothandizila, kukana pang'ono kwa mankhwalawa (munthawi yophatikiza mankhwala), matenda wamba, mtundu wachiwiri wa matenda ashuga a akazi apakati.

Contraindication

Hypoglycemia, kukulitsa chidwi cha munthu ndi insulin.

Kwa sc makonzedwe okha. Mlingo wa mankhwalawa umatsimikiziridwa ndi dokotala aliyense payekhapayekha, potengera kuchuluka kwa shuga m'magazi.

Pafupifupi, tsiku lililonse mlingo umachokera ku 0,5 mpaka 1 IU / kg kulemera kwa thupi (kutengera umunthu wa wodwalayo komanso kuchuluka kwa shuga).

Zotsatira zoyipa chifukwa cha kagayidwe kazachilengedwe: Hypoglycemic zinthu (pallor of the khungu, thukuta kwambiri, palpitations, kugwedeza, njala, kukwiya, paresthesia wa m`kamwa mucosa, kupweteka kwa mutu, chizungulire, utachepa kuwona acuity). Matenda oopsa a hypoglycemia angayambitse kukula kwa chikomokere kwa hypoglycemic.

Zotsatira zoyipa: zotupa pakhungu, edema ya Quincke, kuwopsa kwa anaphylactic.

Zomwe zimachitika: Hyperemia, kutupa ndi kuyabwa pamalowo jekeseni, ndikugwiritsa ntchito nthawi yayitali - lipodystrophy pamalo opangira jekeseni.

Zina: kutupa, kuchepa kwakanthawi pang'onopang'ono mu mawonekedwe acuity (nthawi zambiri kumayambiriro kwa chithandizo).

Kuyanjana kwa mankhwala

Hypoglycemic zotsatira za insulin patsogolo mankhwala m'kamwa hypoglycemic, Mao zoletsa, zoletsa Ace, carbonic zoletsa anhydrase, kusankha beta-blockers, bromocriptine, octreotide, sulfonamides, anabolic mankhwala, tetracyclines, clofibrate, ketoconazole, mebendazole, pyridoxine, theophylline, cyclophosphamide, fenfluramine, kukonzekera lifiyamu kukonzekera kokhala ndi Mowa.

Hypoglycemic zotsatira za insulin zimaphatikizidwa ndi glucagon, somatropin, estrogens, njira zakulera zamkati, corticosteroids, mankhwala okhala ndi chithokomiro, thiazide diuretics, "loop" diuretics, heparin, tricyclic antidepressants, graconid clonine, clonidine clonidine clon. , diazoxide, morphine, phenytoin, chikonga.

Mothandizidwa ndi reserpine ndi salicylates, onse ofooketsa ndikuwonjezera zochita za insulin ndizotheka.

Imachepetsa kulolera kwa ethanol.

Malangizo apadera

Potengera maziko a mankhwala a insulin, kuyang'anira kuchuluka kwa shuga m'magazi ndikofunikira.

Zomwe zimayambitsa hypoglycemia kuwonjezera pa insulin yochulukirapo imatha kukhala: kuthana ndi mankhwala, kudumpha chakudya, kusanza, kutsegula m'mimba, kuchuluka kwa zochitika zolimbitsa thupi, matenda omwe amachepetsa kufunikira kwa insulin (chiwindi ndi matenda a impso, hypofunction ya adrenal cortex, pituitary kapena chithokomiro cha chithokomiro), kusintha kwa jekeseni wa jekeseni, komanso kuyanjana ndi mankhwala ena.

Dosing yolakwika kapena kusokonezedwa mu kayendetsedwe ka insulin, makamaka kwa odwala omwe ali ndi matenda amtundu wa 1, angayambitse matenda a hyperglycemia. Nthawi zambiri zizindikiro zoyambirira za hyperglycemia zimayamba pang'onopang'ono kwa maola angapo kapena masiku.

Izi zikuphatikiza mawonekedwe a ludzu, kukodza mwachangu, nseru, kusanza, chizungulire, khungu komanso kuwuma pakhungu, pakamwa pouma, kusowa chilimbikitso, kununkhira kwa acetone mu mpweya wotuluka.

Ngati sanalandire, hyperglycemia mu mtundu 1 wa shuga angayambitse kukula kwa matenda ashuga a ketoacidosis.

Mlingo wa insulin uyenera kusinthidwa kuti matenda a chithokomiro asokonekera, matenda a Addison, hypopituitarism, chiwindi ndi impso, komanso matenda oopsa a shuga kwa odwala azaka zopitilira 65.

Poona chiwopsezo cha mtima ndi chithokomiro chamatenda a hypoglycemia, kukonzekera kwa insulini kuyenera kugwiritsidwa ntchito mosamala kwa odwala omwe ali ndi vuto lalikulu la mitsempha ya m'mimba ndi matenda amitsempha.

Mosamala odwala omwe ali ndi proliferative retinopathy, makamaka osalandira chithandizo ndi Photocoagulation (laser coagulation) chifukwa choopsa cha amaurosis (khungu lathunthu).

Wodwalayo akachulukitsa mphamvu zolimbitsa thupi kapena asintha zakudya zomwe amakonda, kusintha kwa insulin kungafunike.

Matenda onga, makamaka matenda ndi machitidwe omwe amatsatana ndi malungo, amalimbikitsa kufunika kwa insulini.

Kusamutsa wodwala ku mtundu wina wa insulin kapena kukonzekera kwa insulin kwa wopanga wina kuyenera kuchitika moyang'aniridwa ndi dokotala.

Mukamagwiritsa ntchito insulin pokonzekera limodzi ndi mankhwala a gulu la thiazolidinedione, odwala omwe ali ndi matenda a shuga 2 amatha kudwala kwamadzimadzi, zomwe zimawonjezera chiopsezo chotukuka ndikupitilira patsogolo kulephera kwa mtima, makamaka kwa odwala omwe ali ndi matenda amtima komanso kupezeka kwa chiopsezo chodwala. kulephera kwa mtima. Odwala omwe amalandila chithandizo chotere ayenera kuunikiridwa pafupipafupi kuti adziwe zizindikiro za kulephera kwa mtima. Ngati kulephera kwa mtima kumachitika, mankhwalawa akuyenera kuchitika molingana ndi momwe mankhwalawa alili. Poterepa, ndikofunikira kulingalira kuthekera kochotsa kapena kuchepetsa mlingo wa thiazolidatedione.

Mimba komanso kuyamwa

Palibe choletsa pa chithandizo cha matenda osokoneza bongo a shuga ndi insulin panthawi yapakati, chifukwa insulin siyidutsa chotchinga. Mukakonzekera kukhala ndi pakati komanso panthawi imeneyi, ndikofunikira kulimbikitsa chithandizo cha matenda ashuga. Kufunika kwa insulin nthawi zambiri kumachepera mu trimester yoyamba ya kutenga pakati ndipo kumawonjezeka pang'onopang'ono kwachiwiri komanso kachitatu.

Nthawi yobadwa pambuyo pokhapokha ndipo mwayamba kubadwa, zofunika za insulin zimatha kugwa kwambiri. Pambuyo pobadwa, kufunikira kwa insulin kumabwereranso msanga momwe kunaliri asanakhale ndi pakati.

Kufotokozera kwa mankhwala PROTAMIN-INSULIN ES kutengera malangizo ovomerezeka ovomerezeka ndi opanga.

Mwapeza cholakwika? Sankhani ndikusindikiza Ctrl + Lowani.

PROTAMIN-INSULIN CHS 100ME / ML 10ML SUSP P / K FLAK

Kuyimitsidwa ndi koyera. Mukayimirira, kuyimitsidwa kumafanana ndikupanga chopanda utoto kapena chosakhala ndi utoto komanso choyera choyera, chomwe chimatha kukhala ndi zigamba zomwe zimayambitsidwa mosavuta ndikuyambitsa.

1 ml ya mankhwala ali: yogwira mankhwala: anthu chibadwa cha insulin 100 IU,

excipients: protamine sulfate 0,35 mg, sodium hydrogen phosphate dihydrate 2.4 mg, zinc chloride 0.018 mg, phenol 0.65 mg, metacresol 1.5 mg, glycerol (glycerin) 16,0 mg, madzi a jakisoni mpaka 1 ml .

PROTAMIN-INSULIN HS (PROTAMIN-INSULIN HS)

Poyerekeza ndi maziko a mankhwala a insulin, kuyang'anira kuchuluka kwa shuga m'magazi ndikofunikira.

Zomwe zimayambitsa hypoglycemia kuwonjezera pa insulin yochulukirapo imatha kukhala: kuthana ndi mankhwala, kudumpha chakudya, kusanza, kutsegula m'mimba, kupsinjika kwa thupi, matenda omwe amachepetsa kufunikira kwa insulin (chiwindi ndi matenda a impso, hypofunction ya adrenal cortex, pituitary kapena chithokomiro cha chithokomiro), komanso kusintha kwa jekeseni, komanso kucheza ndi mankhwala ena.

Kulephera kapena kusokoneza kwa insulin makonzedwe, makamaka kwa odwala omwe ali ndi matenda amtundu wa 1, angayambitse matenda a hyperglycemia. Nthawi zambiri, zizindikiro zoyambirira za hyperglycemia zimayamba pang'onopang'ono kwa maola angapo kapena masiku.

Izi zikuphatikiza ludzu, kukodza kwambiri, nseru, kusanza, chizungulire, khungu ndi kuwuma pakhungu, pakamwa pouma, kusowa chilimbikitso, kununkhira kwa acetone mu mpweya wotuluka.

Ngati sanalandire, hyperglycemia mu mtundu 1 wa shuga angayambitse kukula kwa matenda ashuga a ketoacidosis.

Mlingo wa insulin uyenera kukonzedwa kuti matenda a chithokomiro asokonezeka, matenda a Addison, hypopituitarism, chiwindi ndi impso komanso odwala omwe ali ndi zaka zopitilira 65.

Matenda onga, makamaka matenda ndi machitidwe omwe amatsatana ndi malungo, amalimbikitsa kufunika kwa insulini.

Kuwongolera mlingo wa insulin kungafunikenso ngati wodwala akuwonjezera kuchuluka kwa zochitika zolimbitsa thupi kapena asintha zakudya zomwe amakonda.

Kusintha kuchokera ku mtundu kapena mtundu wa insulin kupita ku wina kuyenera kuchitika moyang'aniridwa ndi dokotala. Kusintha kwa ndende, dzina la chida (wopanga), mtundu (waufupi, wapakati komanso wautali wa insulini, ndi zina zambiri.

,, mtundu (wa munthu, chinyama) ndi / kapena njira yopangira (kuyambitsa nyama kapena ma genetic) ingafune kusintha kwa insulin.

Kufunika kwa kusintha kwa mankhwala a insulin kumatha kuwonekera pambuyo pa ntchito yoyamba, komanso pakatha milungu ingapo kapena miyezi ingapo.

Pakusintha kuchokera ku insulin yochokera ku nyama kupita ku Protamine-insulin mwadzidzidzi, odwala ena adawona kusintha kapena kufooka kwa Zizindikiro zakutsogolo kwa hypoglycemia.

Milandu yolipirira chakudya cha kagayidwe kachakudya, mwachitsanzo, chifukwa cholimbitsa insulin, Zizindikiro zomwe zimakhazikitsidwa ndi hypoglycemia zimatha kusintha, zomwe odwala ayenera kuchenjezedwa.

Milandu yakulephera kwa mtima yanenedwa pamodzi ndi kuphatikiza kwa insulin ndi thiazolidatediones, makamaka kwa odwala omwe ali ndi chiopsezo cha mtima. Izi ziyenera kukumbukiridwa pakugawa kuphatikiza uku.

Ngati kuphatikiza pamwambapa kumayikidwa, ndikofunikira kuzindikira zizindikiritso za mtima wake, kulemera kwake, edema. Kugwiritsa ntchito pioglitazone kuyenera kuyimitsidwa ngati zizindikiro za mtima zizikulirakulira.

Kukopa pa kuyendetsa magalimoto ndi kayendedwe kazinthu

Kuthekera kwa odwala kulolera komanso kuchuluka kwa zomwe zimachitika amatha kulemala panthawi ya hypoglycemia ndi hyperglycemia, zomwe zimakhala zowopsa, mwachitsanzo, poyendetsa magalimoto kapena kugwira ntchito ndi makina ndi makina.

Odwala ayenera kulangizidwa kuti achitepo kanthu popewa kukulitsa kwa hypoglycemia ndi hyperglycemia poyendetsa galimoto ndikugwiritsa ntchito njira.

Izi ndizofunikira kwambiri kwa odwala omwe alibe kapena kuchepa kwa zizindikiro zakutsogolo kwa hypoglycemia kapena akuvutika ndi zochitika zapafupipafupi za hypoglycemia. Zikatero, kuyendetsa bwino kuyenera kuganiziridwa.

Protamine-insulin mwadzidzidzi: malangizo ogwiritsira ntchito

Kudzipatsa nokha mankhwala kungavulaze thanzi lanu.
Ndikofunikira kufunsa dokotala, komanso kuwerenga malangizo musanayambe kugwiritsa ntchito.

Muli 1 ml: ntchito: genetic engineering insulin - 100 ME, zokopa: protamine sulfate, disodium phosphate dihydrate, zinc chloride, phenol, metacresol, glycerin, madzi a jekeseni.

kuyimitsidwa kwa jekeseni 100 IU / ml.

Zopangidwa ku Belarus - moyo pamitu ya insulin

Svetlana KAZACHONOK, Minsk, mtundu wa matenda ashuga omwe ndimakumana nawo - zaka 45

Kupambana pochiza matenda a shuga kumatengera zinthu zambiri, koma chofunikira kwambiri ndikupezeka kwa insulini yabwino. Uku ndikumaliza kwanga, kutengera zaka 45 zokumana nazo - kuyambira wazaka 12, kuchokera ku 1963, ndidasintha moyo wanga ndikumatha "nsonga" za insulini ...

Ndinkamaliza sukulu, koleji ndipo kwa zaka zambiri ndakhala ndikugwira ntchito ku Minsk Porcelain Factory. Matenda a shuga pafupifupi sanandilande chisangalalo cha moyo, zinangokhala zochitika za tsiku ndi tsiku. Koma funso la insulin nthawi zonse limakhala lowawa.

Monga munthu aliyense wodwala matenda ashuga wazaka zapitazi, ndayesa mitundu yambiri - nkhumba, ng'ombe, maumboni opanga majini. Mu zaka za sukulu adalandira imodzi mwazabwino kwambiri nthawi imeneyo - insulin-B. Koma mpaka atazolowera, sanazolowere, mankhwalawo adabweretsa mavuto ambiri.

Kenako insulin iyi inasowa, ina inaonekanso - ICCA (amorphous zinc - kuyimitsidwa kwa insulin). Anasiya mawonekedwe osangalatsa kwambiri - mutu, nseru, kukhumudwa. Pomwe ankaphunzira ku BPI, anali kuchipatala kangapo chifukwa cha tsankho ku ICCA.

Kenako idasinthidwa ndi protamine - zinc - insulini kuphatikiza yosavuta, ndipo shuga inachepetsedwa bwino, mutu umamupweteka, komanso unayipidwa. Wopulumutsa wachinyamata. Kubwera kwa monotard, adamva bwino, koma zovuta zidawonekera. Ndipo nthawi zambiri monotard amatha.

Chiwonetsero chakuchezera kwa endocrinologist mu 80s chinali chophweka kwambiri: adokotala adalengeza zowonjezera za insulin (modekha kwambiri), ndipo ndidasankha yowonjezera. Anayesa kangapo kusinthana ndi insulin ya Belarusi, koma sizinathandize. Ngakhale kuchuluka kwa mlingo sikunayambitse kuchepa kwa shuga.

Kuyambira mwezi mpaka mwezi kwa pafupifupi zaka 25, sindinadziwe kuti ndi ma insulin ati mawa. Koma sanakayikire zam'tsogolo.

Nthawi zovuta kwambiri kwa odwala matenda ashuga a ku Belarus ali pazaka za perestroika. Mu 1996, ndi leapfrog ndimatenda a insulin, ndinayamba kukhala ndi matenda a mafupa am'madzi, ndinagona kuchipatala pafupifupi miyezi itatu. Madokotala anayesera, koma sanathe kuletsa njira yotupa.

Sathanso kuyenda, analira ndi ululu, mwendo wake unasanduka chipika, ndipo kwa pafupifupi chaka kutentha. Kupulumutsidwa kunachokera kwa bwenzi lomwe limatulutsa insulin ya Danish yabwino komanso glucometer yokhala ndi zingwe zoyeserera.

Kuwongolera shuga, osalola kuti ikhale pamwamba pa 7-8 mmol / l, adachita bwino, adafika pamapazi ake.

Ndimakumbukira bwino mu June 2001, pamene ndidakumana ndi endocrinologist ku chipatala changa ndidazindikira kuti palibe insulin ya odwala konse. Ndi zovuta adadzikoka pamodzi, kukakamiza kutaya mtima (momwe zinaliri, mlongo anali kunyumba atamuchita opaleshoni yovuta, amafunikira thandizo langa). Apanso anzanga anathandiza.

Kuyambira nthawi imeneyo, ndinasiya kupita kwa dotolo ndipo ndinalandira chithandizo pandekha. Ndinasinthira majakisoni angapo, ndikupeza ma insulin ochokera kumayiko ena ogulitsa. Koma kumapeto kwa 2008. Ndipo panali kusokonezeka nawo ku Minsk.

Ndidafunikira kupita ku disensary ya mzindawo, komwe adandiuza za insulin yatsopano yopanga ma Belarusian ndipo adadzipereka kuti ndiyesere.

Popeza sindinasankhe, ndinavomera, koma osachita chidwi.

Tsiku lotsatira, ma insulin aku Belarus adayamba kubaya. Mlingo wapitawu sunasinthe. Sabata inadutsa, iwiri, itatu ... sindinasinthe ma doses, chifukwa

Zizindikiro za shuga zamagazi zinali zofanana ndi iwo omwe ali ndi mankhwala ochokera kunja. Mwachitsanzo, magawo 10 a insulin osakhalitsa amachepetsa shuga yanga pafupifupi 3 mmol / L, chimodzimodzi zomwe zinachitika ndi ES protamine - insulin.

Palibe zochitika zoyipa (kupweteka mutu, nseru) zomwe zidawoneka. Ndikumva bwino.

Kodi zimachitidwadi?! Genulin insulin yapamwamba kwambiri yopanga zoweta yawonekera! Kupatula apo, izi zikutanthauza kuti ambiri odwala matenda ashuga ku republic athu amatha kulandira chithandizo moyenera, kukhazikitsa mapulani awo osamwalira pasadakhale chifukwa cha zovuta.

Ndikuthokoza kwambiri anthu omwe anakwanitsa ntchito yofunikayi. Pomaliza, odwala matenda ashuga adamva chisamaliro cha boma. Njira yomwe yatitsogolera yatenga chiyembekezo, sindikuti komaliza!

ZOYENELA

Akatswiri a zamankhwala ku Belarus apanga mtundu watsopano wa insulin yopanga ma genetically yochokera ku kampani ya Scandinavia yapadziko lonse lapansi. Zaka ziwiri zapitazo, Belmedpreparaty LLC inatumiza katundu woyamba kuzipatala.

Kuyankha kwa anthu odwala matenda ashuga kunali kawiri. Mbali imodzi, zachidziwikire, chisangalalo ndi chiyembekezo: pamapeto pake "inshuwaransi" yawo

Pazinsinsi za boma, izi ndizosungirako ndalama zambiri, ndipo kwa odwala matenda ashuga ndikutsimikiza kuti ma insulin amakono (amatchedwanso "anthu") tsopano akupezeka osati kwa ana okha, komanso kwa achikulire odwala, kuti musawope kupereka chisokonezo ndikusintha mokakamizidwa kuchokera ku insulin imodzi mbali inayo (izi nthawi zambiri zimayambitsa kuwonongeka kwa matenda ashuga).

Koma panthawi imodzimodziyo, anthu anali ndi nkhawa: momwe mankhwala apamwamba kwambiri komanso ogwira mtima amagwiritsira ntchito? Ambiri, monga wolemba kalatayo, adapatsidwa zifukwa zodzidzimutsa chifukwa cha zomwe adakumana nazo kale.

Poganizira za nkhondo iyi, mfundo zosatsimikizika zomwe zidasinthidwa mwachangu zidasanduka "mpira wamatalala" - mphekesera zomwe zidakulirakulira pakati pa anthu odwala matenda ashuga: "Ndipo ma inshuwaransi am'nyumba ndi oyipa!" Posachedwa, pamakhala kutsutsana kwambiri komanso kufalitsa nkhani pankhaniyi.

Pakadali pano, akatswiri - madokotala, asayansi, akatswiri opanga zida - anali mwakachetechete, m'njira ngati bizinesi, kuthetsa vutoli.

Ntchito ya endocrinology ya republic idawululira ndikuwunikira chilichonse chosakwanira kapena zoyipa zoyipa zatsopano zaku Belarus, komanso kupezeka kwa matope oyera m'mabotolo, omwe samachotsedwa pokonzekera njira yoyendetsera.

Zochitika zomalizazi zinali chifukwa chakuwongolera kwakukulu kwaukadaulo wopanga insulini masiku ano, malinga ndi opanga ndi madokotala, nkhaniyi yathetsa, palibe "banja". Komabe, wodwalayo ayenera kutsatira mosamalitsa malangizo osungira ndikugwiritsa ntchito mankhwalawa kuti apeze mphamvu zambiri.

Ponena za kagwiritsidwe ka ntchito ka Belarus insulin, odwala eni ake amadziwa bwino: pano zambiri zimatengera mawonekedwe amunthu, pali odwala matenda ashuga omwe ngakhale mankhwala omwe amagwiritsidwa ntchito kale kwambiri "sapita nawo". Chifukwa chake, m'malo osungirako muli zofananira zamakampani ena - kuthekera kwa kusankha payekha.

Koma pali mbali yolandila ndalama.

Kuti insulini "igwire ntchito" zana limodzi, munthu wodwala matenda ashuga ayenera kuchita moyenera: kuyeza shuga m'magazi, kuwerengera kuchuluka kwa mafuta omwe adwedwa, kudziwa kuchuluka kwa jakisoni wa insulin molingana ndi zofunikira za thupi. Muyenera kuphunzira izi - kuchokera m'mabuku, ku "sukulu ya shuga", mothandizidwa ndi dokotala. Ndipo gwiritsani ntchito chidziwitso chomwe mumapeza m'moyo watsiku ndi tsiku. Koma si onse, makamaka achikulire, omwe amachita.

Natalia Mikhailovna LIKHORAD, wamkulu wa dipatimenti yachipatala ya City Clinical Hospital No 1 ku Minsk, anati: "Tidazindikira zomwe zimayambitsa kubwereza matenda a shuga pogwiritsa ntchito insulin zatsopano za Belarus, tinasanthula bwino za wodwalayo aliyense.

Ndipo anali pafupifupi otsimikiza nthawi zonse: kubwezeredwa kunali kale, pazinthu zina. Cholinga chake ndikuchepa kwa kuwerenga kwa matenda ashuga, kusafuna kudzipangira.

Udindo waukulu udachitika chifukwa cha malingaliro omwe odwala ali nawo pakuwona zolakwika zatsopano za insulin. "

Kupanga chatsopano chogulitsa mankhwala, kudziwa kutulutsidwa kwake ndi bizinesi yovuta kwambiri, yodula komanso yayitali. Sikuti zonse zimachitika nthawi yomweyo. Izi ziyenera kumvetsedwa. Masiku ano, ma endocrinologists atsimikiza kuti palibe mavuto ndi mtundu wa insulin ya Belarusi. Ndipo ali ndi chitsimikizo kuti chifukwa cha inshuin zatsopano ku republic padzakhala zovuta zochepa ndi chithandizo cha matenda ashuga.

Malingaliro a akatswiri adaperekedwa ndi Olga SVERKUNOVA

Protafan: malangizo ogwiritsa ntchito. Momwe mungasinthire, choti mubweze

Mediulin Insulin Protafan: Phunzirani Zonse Zomwe Mukufuna. Pansipa mupeza malangizo ogwiritsira ntchito olembedwa m'chinenerochi.

Mvetsetsani momwe mungasankhire mulingo woyenera wa anthu akuluakulu ndi ana odwala matenda ashuga, kangati patsiku kuti mupeze jakisoni, zabwino ndi zovuta zake.

Werengani zithandizo zothandiza zomwe zimapangitsa kuti magazi anu akhale ndi shuga 3.9-5,5 mmol / L khola maola 24 patsiku, monga momwe zimakhalira ndi anthu athanzi. Dongosolo la Dr. Bernstein, amene akhala ndi matenda ashuga kwa zaka zoposa 70, amathandiza kuteteza ku zovuta zoopsa.

Protafan ndi insulin yomwe imagwira ntchito pakati yomwe imagwiritsidwa ntchito pochiritsa odwala matenda ashuga ambiri mdziko lolankhula Russia. Zimapangidwa ndi kampani yotchuka yapadziko lonse Novo Nordisk. Insulin yapakatikati imatulutsidwanso komanso kukonzekera kwanyumba Humulin NPH, Insuman Bazal, Biosulin N, Rinsulin NPH ndi ena. Tsambali lidzakhala lothandiza kwa odwala matenda ashuga omwe amathandizidwa ndi mankhwalawa.

Mediulin Insulin Protafan: Nkhani Yotsimikizika

Odwala ambiri ali ndi chidwi ndi zomwe Protafan ikhoza kusintha. Pansipa mupeza yankho la funso ili. Kwambiri ndi kufananizira kwa insulin yochita pakati komanso mankhwala atsopano a Levemir.

Malangizo ogwiritsira ntchito

Mukabaya insulin Protafan, Humulin NPH, Insuman Bazal, Biosulin N kapena Rinsulin NPH, muyenera kutsatira zakudya.

Mtundu wa matenda a shuga a 2 Mtundu woyamba wa shuga Zakudya tebulo No. 9 Masamba a sabata: Zitsanzo

Anthu ambiri odwala matenda ashuga omwe amathandizidwa ndi insulin sawona kuti ndizotheka kupewa kukhala ndi vuto la hypoglycemia. M'malo mwake, izi siziri choncho. Mutha kusunga shuga wokhazikika ngakhale ndi matenda oopsa a autoimmune.

Ndipo makamaka, ndi matenda a shuga a 2 ochepa. Palibe chifukwa chakuwonjezera kuchuluka kwa shuga m'magazi anu kuti mudzilimbitse nokha motsutsana ndi hypoglycemia yoopsa. Onerani kanema pomwe Dr. Bernstein akufotokoza nkhaniyi.

Maso (retinopathy) Impso (nephropathy) Matenda a shuga Atsitsi: miyendo, mafupa, mutu

Otsatirawa ndiwowonjezera pazakudya zamakina a insulin.

Kodi protafan ndi mankhwala a kanthu?

Protafan ndi insulin yomwe imagwiritsa ntchito pakati. Amayamba kutsika magazi 60-90 patatha mphindi jakisoni.

Ili ndi chiwongola dzanja chodziwika bwino, mosiyana ndi mankhwala ataliatali a Levemir, Tresiba, Lantus ndi Tujeo. Izi zimatheka pambuyo maola 3-5.

Monga lamulo, insulini yapakatikati iyenera kugwiritsidwa ntchito limodzi ndi mankhwala afupikitsa kapena a ultrashort. Werengani zambiri mu nkhani "Mitundu ya Insulin ndi Zotsatira Zawo".

Mungamayike bwanji?

Kutalika kwa jakisoni aliyense ndi maola 12-18. Chifukwa chake, Protafan ndikulimbikitsidwa kuti jekeseni katatu patsiku. Komabe, odwala matenda ashuga omwe amatsata zakudya zama carb ochepa amafunika Mlingo wa insulin 2-8 nthawi yotsika kuposa muyezo.

Mlingo wotere, Protafan imagwira ntchito osaposa maola 8, ndipo iyenera kuperekedwa katatu patsiku. Mwambiri, jakisoni wamadzulo sangakhale wokwanira usiku wonse.

Kuti mupewe mavuto m'mawa m'mimba yopanda kanthu, komanso kuti muchepetse zovuta zoyipa, ndibwino kuti muthetse Protafan ndi imodzi mwa mankhwalawa Levemir, Tresiba, Lantus kapena Tujeo.

Kodi Protafan ikhoza kugawidwa panjakisoni 3 patsiku?

Chabwino ndikubwezeretsani insulin yapakatikati ndi Levemir, Lantus, Tujeo kapena Tresiba.

Tiyerekeze, pazifukwa zina, muyenera kupitiliza kugwiritsa ntchito Protafan, Humulin NPH, Insuman Bazal, Biosulin N kapena Rinsulin NPH. Poterepa, ndizomveka kugawanitsa m'magulu atatu a jekeseni patsiku.

Nthawi yoyamba imayendetsedwa m'mawa, atangodzuka. Jekeseni wachiwiri - pa nkhomaliro, mlingo wochepera. Nthawi yachitatu - usiku musanagone, mochedwa momwe mungathere.

Mavuto akulu amakumana ndi mlingo wa usiku. Chifukwa choti insulin ya sing'anga imatha posachedwa, sikokwanira usiku wonse. Kuwonjezeka kwa mlingo womwe umaperekedwa asanagone kumayambitsa usiku hypoglycemia.

Kuwombera kwa insulin Protafan kapena kufananiza kwake pakapakati, komwe sikumayambitsa hypoglycemia yausiku, kumapangitsa shuga kukhala m'mawa kwambiri pamimba yopanda kanthu.

Vutoli lilibe yankho labwino, kupatula kusinthana ndi mtundu wina wa insulin.

Kodi insulin yamtunduwu imayendetsedwa musanadye kapena pambuyo chakudya?

Protafan sanapangidwe kuti chakudya chiziwayika. Komanso, sioyenera kukhala ndi malo omwe mumafunika kuti muchepetse shuga msanga. Iyenera kumanidwa, ngakhale zakudya, nthawi zambiri tsiku lililonse. Nthawi zambiri, limodzi ndi izo, kukonzekera kwina kwapadera kapena kwa ultrashort kumagwiritsidwa ntchito, komwe kumayendetsedwa musanadye.

Kodi mlingo wovomerezeka watsiku ndi tsiku ndi uti?

Mwauli, mulingo wovomerezeka wa tsiku ndi tsiku wa insulin Protafan sunakhazikitsidwe. Ndikulimbikitsidwa kupaka jekeseni momwe ndingafunikire kuti shuga m'magazi a odwala matenda ashuga asatuluke kwambiri.

Komabe, milingo yayikulu ya insulin imadumphira m'magulu a shuga, pafupipafupi komanso pafupipafupi matenda a hypoglycemia. Chifukwa chake, muyenera kufunafuna kunyengerera kwabwino kwambiri.

Werengani zambiri mu nkhani "Kuwerengera kwa Insulin Dose: Mayankho a Mafunso Awaga".

Protafan kapena Levemir: ndi insulin iti yabwino? Kodi amasiyana bwanji?

Levemir ndiyabwino kuposa Protafan chifukwa imatenga nthawi yayitali. Mulibe mapuloteni a protamine, omwe nthawi zambiri amayambitsa ziwopsezo zonse.

Koma Protafan, ngati ndi kotheka, imatha kuchepetsedwa ndi saline, yomwe imagulitsidwa ku pharmacy. Izi ndizofunikira pakulipira shuga kwa ana omwe amafuna inshuwaransi yochepa.

Levemir amalowetsanso ana mu mawonekedwe osakanikirana, koma wopanga sanavomereze izi.

Ndingatchule chiyani Protafan?

Insulin yapakatikati imalimbikitsidwa mwamphamvu kuti isinthidwe ndi imodzi mwamankhwala: Levemir, Tresiba (yabwino kwambiri, koma yodula), Lantus kapena Tujeo.

Zitha kuchitika kuti mupatsidwa Protafan kwaulere, ndipo mudzayenera kugula mitundu ina ya insulin yayitali ndalama zanu. Ngakhale zili choncho, mukufunikabe kusintha mankhwalawo.

Chifukwa kuchiza matenda ashuga omwe ali ndi insulini yapakati kumakhala ndi zovuta zina. Werengani zambiri za iwo apa.

Insulin Protafan: ndemanga za anthu odwala matenda ashuga

Kodi azimayi oyembekezera amatha kumwetulira?

Kugwiritsa ntchito mitundu yachiwiri ya insulin Protafan, Humulin NPH, Insuman Bazal, Biosulin N ndi Rinsulin NPH panthawi yapakati komanso yoyamwitsa ndikovomerezeka. Imavomerezedwa ndi Unduna wa Zaumoyo. Komabe, ndibwino kugwiritsa ntchito imodzi mwazosankha za insulin yayitali (yowonjezera) yomwe yatchulidwa pamwambapa. Kuwongolera matenda a shuga kwa amayi apakati, Levemir nthawi zambiri amadziwika.

Protamine-insulin ES - Insulin (yaumunthu), zikugwiritsira ntchito, kufotokoza, katundu. Hypoglycemic wothandizila, wokhala nthawi yayitali insulin - Protamine-insulin mwadzidzidzi

Wopanga: RUE Belmedpreparaty Republic of Belarus

Khodi ya PBX: A10AC01

Gulu la Alimi:
Mankhwala ochiza matenda ashuga

Kutulutsa Fomu:
Mitundu yamadzi yamankhwala. Kuyimitsidwa kwa jakisoni.

Zisonyezero zogwiritsidwa ntchito:
Shuga wokoma.

Makhalidwe

Mankhwala Pambuyo pakukhazikitsidwa pansi pa khungu (mu mafuta onunkhira), Protamine-insulin mwadzidzidzi imayamba kugwira ntchito mkati mwa maola 1.5 ndipo imakhala ndi zotsatira zazikulu pakati pa 4th ndi 12 ora, nthawi ya mankhwalawa imafika mpaka maola 24. Chifukwa cha nthawi yayitali yochita, chitetezo cha Protamine-insulin nthawi zambiri chimafotokozedwa mu nyimbo ndi insulin kukonzekera kwakanthawi.

Njira yogwiritsira ntchito ndi kumwa:

Mosasunthika. Zosakhala bwino, momwe hyperglycemia ndi glucosuria sizichotsedwa ndi zakudya kwa masiku atatu, pamlingo wa 0.5-1 U / kg, ndiye kuti mlingo umasinthidwa malinga ndi mbiri ya glycemic ndi glucosuric.

Kutalika kwa kayendetsedwe kake kuyenera kukhala kosiyana (nthawi zambiri 3-5 amagwiritsidwa ntchito posankha mlingo), pomwe mpesa wonse wagawidwa m'magawo angapo, molingana ndi mphamvu ya chakudya chomwe chatengedwa.

Jekeseni ikuchitika mphindi 15 chakudya chisanafike.

Zomwe Mungagwiritse Ntchito:

Zokhudza mphamvu pakuyendetsa magalimoto ndi kayendedwe kazinthu.

Pokhudzana ndi cholinga choyambirira cha insulin, kusintha kwa mtundu wake kapena kukhalapo kwa kupsinjika kwakukulu kwakuthupi kapena kwamaganizidwe, kukhoza kuchepa kwa kuyendetsa galimoto kapena kuwongolera njira zosiyanasiyana, komanso kuchita zina zomwe sizingakhale zotetezeka zomwe zimafuna chisamaliro chapadera komanso kuthamanga kwa zochitika zamagetsi ndi zamagalimoto.

Zotsatira zoyipa:

ES protamine-insulin ikhoza kuyambitsa hypoglycemia, redness, kutupa ndi kuyabwa kumatha kuoneka pamalo opangira jakisoni (omwe amadziwika kuti ndi mziwopsezo). Nthawi zambiri, mukapitiliza kugwiritsa ntchito mankhwalawa, zizindikirazi zimazimiririka patangopita milungu yochepa.

Nthawi yoyamba yomwe idayamba ndi chithandizo cha insulin, imatha kusokoneza kuwonongeka kwa mawonekedwe kapena kutupa miyendo.

Kubayidwa pafupipafupi pamalo amodzi kumatha kubweretsa kukula kwa khungu kapena minofu ya m'mimba (lipodystrophy).

Mogwirizana ndi mankhwala ena:

Pali mitundu ingapo ya mankhwala yomwe imakhudza kufunika kwa insulin:

Othandizira a hypoglycemic othandizira, ma monoamine oxidase inhibitors (MAO), osagwiritsa ntchito beta-blockers, angiotensin kutembenuza ma enzyme (ACE) zoletsa, salicylates, anabolic steroids ndi glucorticoids, njira zakulera pakamwa, mahomoni a diazitrate, mahomoni a chithokomiro.

Bongo

Zizindikiro: Ngati mankhwala osokoneza bongo atha kukhala pali hypoglycemia.

Chithandizo: wodwalayo amatha kuchotsa yekha hypoglycemia yekha, kutenga shuga kapena zakudya zamagulu ena owonjezera mkati. Chifukwa chake, tikulimbikitsidwa kunyamula shuga, maswiti, ma cookie kapena msuzi wa zipatso zotsekemera ndi iyo nthawi zonse mu shuga yotsekemera yopanda thanzi.

Mwa languid milandu, pamene wodwala ataya chikumbumtima, 40% njira ya glucose imalowetsedwa kudzera m'mitsempha, intramuscularly, subcutaneally, kudzera m'mitsempha - glucagon. Pambuyo pozindikira, wodwalayo amalangizidwa kuti azidya zakudya zokhala ndi mchere wambiri kuti alepheretse kukonzanso kwa hypoglycemia.

Malo osungirako:

Botolo lomwe lili ndi mankhwala a Protamine-Insulin Emergency, omwe mukugwiritsa ntchito pakadali pano, amatha kusungidwa kutentha kwafitimu (mpaka 25 ° C) kwa milungu isanu ndi umodzi.

Mbale za Protamine-Insulin Emergency siziyenera kuwonekera kutenthedwa kapena kuwotcha dzuwa ndipo siziyenera kuzizira konse. Sungani chitetezo cha Protamine-Insulin Emergency m'malo osafikirika ndi ana.

Osamagwiritsanso ntchito insulini tsiku lomaliza lisanathe. Osamagwiritsanso ntchito Protamine-Insulin Emergency ngati yankho silikhala lomveka, lonyezimira kapenanso labwinobwino.

Kutulutsa mawonekedwe, kapangidwe kake ndi ma CD

Kuyimitsidwa kwa jakisoni ndikuyera, pomwe kuyimirira, kuyimitsidwa kwakhazikika, madzi amtunda wopendekera bwino ndi owoneka bwino, opanda mtundu kapena pafupifupi, osachedwa kupindika.

Othandizira: protamine sulfate, disodium phosphate dihydrate, zinc chloride, phenol, metacresol, glycerol, madzi a ndi.

10 ml - mabotolo (1) - ma CD.

Kodi insulini yokhala ndi protamine imagwira ntchito bwanji?

Chinthu chapadera chomwe chimatchedwa protamine chimawonjezeredwa ndi ma insulin omwe amagwiritsa ntchito pakati kuti achepetse kuyamwa kwa mankhwalawo pamalo a jekeseni. Chifukwa cha protamine, kuyamba kwa kuchepa kwa shuga m'magazi kumayambira maola awiri kapena anayi pambuyo pa kuperekedwa.

Kuchuluka kwake kumachitika pambuyo pa maola 4-9, ndipo nthawi yonseyi imachokera ku maola 10 mpaka 16. Magawo oterewa a kuchuluka kwa nthawi yomwe hypoglycemic imayamba imapangitsa kuti ma insulin m'malo mwatsopano azilandira kubisala kwachilengedwe.

Protamine imayambitsa mapangidwe a makulidwe a insulin mwanjira ya ma flakes, chifukwa chake mawonekedwe a protamine insulin ndi amtambo, ndipo kukonzekera konse kwa insulin kumakhala kowonekera. Kapangidwe ka mankhwalawa kumaphatikizanso zinc chloride, sodium phosphate, phenol (yosungirako) ndi glycerin. Mmililita imodzi ya kuyimitsidwa kwa protamine-zinc-insulin ili ndi ma PISCES a 40.

Kukonzekera kwa protamine insulin kopangidwa ndi RUE Belmedpreparaty kumakhala ndi dzina la malonda Protamine-Insulin ChS. The limagwirira ntchito ya mankhwala akufotokozera ndi izi:

1. Kuchita ndi receptor pa nembanemba.
2. Mapangidwe a insulin receptor zovuta.
3. M'maselo a chiwindi, minofu ndi adipose minofu, kaphatikizidwe ka michere imayamba.
4. Kuwala kumalumikizidwa ndikugwidwa ndi minofu.
5. Intracellular glucose transport imathandizira.
6. Mapangidwe a mafuta, mapuloteni ndi glycogen amakondweretsedwa.
7. Mu chiwindi, mapangidwe a mamolekyulu atsopano a shuga amachepetsa.

Njira zonsezi zimapangidwa kuti muchepetse kuchuluka kwa shuga m'magazi ndikugwiritsa ntchito kuti ipange mphamvu mkati mwa selo. Mlingo woyambira komanso nthawi yayitali ya Protamine insulin ESD imatengera mlingo womwe umaperekedwa, njira ndi malo a jakisoni.

Mwa munthu yemweyo, magawo awa amatha kusiyana pamasiku osiyanasiyana.

Zisonyezero zogwiritsidwa ntchito ndi mlingo wa mankhwalawa

Kukonzekera kwa Protamine-zinc-insulin kumawonetsedwa kwa odwala omwe ali ndi mtundu woyamba wa matenda a shuga, ndipo amathanso kulimbikitsidwa kuti azikhala ndi shuga wambiri mumtundu wachiwiri wa matenda.

Izi zimatha kukhala kukana kwa mapiritsi ochepetsa shuga a magazi, ndi kuwonjezera kwa matenda opatsirana kapena matenda ena aliwonse, komanso panthawi yapakati. Odwala omwe ali ndi mtundu wachiwiri wa matenda osokoneza bongo amathandizidwanso kukalandira mankhwala a insulin ngati matenda a shuga akuphatikizidwa ndi zovuta kapena kuvulala kwamitsempha.

Mankhwala osokoneza bongo monga protamine-zinc-insulin amasonyezedwa ngati opaleshoni ndiyofunikira ngati matenda a shuga ayamba kupezeka ndipo manambala a glycemic ndi okwera kwambiri kapena ngati pali mapiritsi.

ES protamine-insulin imayang'aniridwa mosiyanasiyana, mlingo wake umatengera hyperglycemia payokha ndipo amawerengedwa pafupifupi pa kilogalamu imodzi yakulemera kwa thupi. Kuwongolera tsiku ndi tsiku kumayambira ku 0,5 mpaka 1 unit.

Zomwe amapangira mankhwalawa:

• Imayendetsedwa yokha pokhapokha. Mtsempha wa magazi kuyimitsidwa kwa insulin ndi oletsedwa.
• Botolo lotsekedwa limasungidwa mufiriji, ndikugwiritsa ntchito kutentha mpaka madigiri 25 kwa milungu isanu ndi umodzi.
• Sungani insulin vial yomwe imagwiritsidwa ntchito kutentha kutentha kwa mpaka 25 ° C kwa milungu isanu ndi umodzi.
• Kutentha kwa insulin ndi kuyambitsa kuyenera kukhala kutentha kwa chipinda.
• Mothandizidwa ndi kutentha, dzuwa mwachindunji, kuzizira, insulin imataya katundu.
• Asanapereke protamine zinc, insulin zinc imafunikira kuti ikulungike m'manja mwake mpaka yosalala komanso mitambo. Ngati izi sizingachitike, ndiye kuti mankhwalawo sanaperekedwe.

Webusayiti ya jakisoni imatha kusankhidwa kutengera chikhumbo cha wodwalayo, koma ziyenera kukumbukiridwa kuti imatengedwa mwachilungamo komanso pang'onopang'ono kuyambira ntchafu. Malo achiwiri omwe ali pabwino ndi dera lamapewa (minyewa). Nthawi iliyonse mukasankha malo atsopano mkati mwake momwemo kuti musawononge minofu yaying'ono.

Ngati wodwala watchulidwa kuti ayendetse machitidwe a insulin, ndiye kuti protocol zinc insulin imachitika m'mawa kapena madzulo, ndipo akasonyezedwa, kawiri (m'mawa ndi madzulo). Asanadye, pali mtundu wina wa insulin womwe umagwiritsidwa ntchito.

Mtundu wachiwiri wa matenda ashuga, nthawi zambiri Protamine-insulin ES imalembedwa limodzi ndi mankhwala a glypoglycemic, omwe amaperekedwa pakamwa pakulimbikitsa, kuti athandizike.

Mavuto a Insulin

Vuto lalikulu kwambiri la insulin mankhwala ndi kuchepa kwamagazi a shuga m'magazi wamba. Izi zimathandizidwa ndi kuperewera kwa zakudya zamagulu pang'ono ndi chakudya chambiri komanso inshuwaransi yayikulu, kudumpha chakudya, kupsinjika kwa thupi, kusintha malo a jekeseni.

Hypoglycemia imayamba chifukwa cha matenda omwe amakhalapo, makamaka omwe ali ndi kutentha kwambiri, kutsegula m'mimba, kusanza, komanso kugwiritsa ntchito mankhwala othandizira omwe amapangitsa kuti insulini iyambe.

Kuyambika kwadzidzidzi kwa zizindikiro za hypoglycemia kumachitika mwachithandizo cha insulin. Nthawi zambiri, odwala amakhala ndi nkhawa, chizungulire, thukuta lozizira, manja akunjenjemera, kufooka kwachilendo, kupweteka mutu komanso palpitations.

Khungu limakhala lotumbululuka, njala imakulirakulira nthawi yomweyo mseru ukayamba. Kenako chikumbumtima chimasokonezeka ndipo wodwala amagwa. Kuchepetsa kwa shuga m'magazi kumasokoneza bongo ndipo ngati sanapatsidwe, odwala ali pachiwopsezo cha kufa.

Ngati wodwala yemwe ali ndi matenda ashuga akudziwa, ndiye kuti mutha kuchepetsa nkhawa pogwiritsa ntchito shuga kapena msuzi wokoma, makeke. Ndi hypoglycemia wambiri, njira yokhazikika ya glucose ndi glucagon ya intramuscular imathandizidwa kudzera m'mitsempha. Pambuyo pakuwongolera thanzi, wodwalayo ayenera kudya kwambiri kuti asadzachitenso chipongwe.

Kusankhidwa kwa mlingo wosagwirizana kapena makonzedwe osayenerera kungayambitse matenda a hyperglycemia odwala omwe amadalira insulin. Zizindikiro zake zimachulukana pang'onopang'ono, chodziwika kwambiri ndi mawonekedwe ake patatha maola ochepa, nthawi zina mpaka masiku awiri. Thupi limachuluka, kutuluka kwa mkodzo kumawonjezeka, kulakalaka kufooka.

Ndipo pali mseru, kusanza, fungo la acetone kuchokera mkamwa. Popanda insulini, wodwalayo amagwera wodwala matenda ashuga. Chisamaliro chodzidzimutsa cha odwala matenda ashuga ndi gulu la ambulansi amafunika.

Kuti musankhe mlingo woyenera wa mankhwalawa, ndikofunikira kukumbukira kuti pamene wodwala kapena matenda ena asintha, kusintha kwa chithandizo kumafunika. Amawonetsedwa muzochitika zotere:

1. Mavuto a chithokomiro.
2. Matenda a chiwindi kapena impso, makamaka ukalamba.
3. Matenda opatsirana ndi ma virus.
4. Kuchulukitsa zolimbitsa thupi.
5. Kusinthana ndi chakudya china.
6. Kusintha kwa mtundu wa insulin, wopanga, kusintha kuchokera ku nyama kupita ku munthu.

Kugwiritsa ntchito inulin ndi mankhwala ochokera ku gulu la thiazolidinediones (Aktos, Avandia) kumawonjezera chiopsezo cha mtima. Chifukwa chake, odwala omwe ali ndi vuto la mtima amalangizidwa kuti azilimbitsa thupi kuti athe kudziwa edema.

Thupi lawo siligwirizana limatha kukhala lamderalo m'njira yotupa, redness, kapena pakhungu pakhungu. Nthawi zambiri zimakhala zazifupi ndipo zimangoyendera zokha. Mawonetseredwe ofala a ziwengo amayambitsa matenda otupa: kuzungulira thupi, nseru, angioedema, tachycardia, kupuma movutikira. Zikachitika, chithandizo chapadera chimachitika.

Protamine-insulin yodzidzimutsa imayesedwa ngati munthu ali ndi hypersensitivity ndi hypoglycemia.

Insulin Protamine pa mimba ndi mkaka wa m`mawere

Popeza insulin siyidutsa placenta, nthawi ya pakati imatha kugwiritsidwa ntchito kulipiritsa matenda a shuga. Mukakonzekera kutenga pakati, kuwunika kwathunthu kwa amayi omwe ali ndi matenda a shuga akuwonetsedwa.

Woyamba trimester akutsutsana ndi maziko a kuchepa kwa kufunika kwa insulin, ndipo chachiwiri ndi chachitatu ndi kuwonjezeka pang'onopang'ono kwa mankhwala omwe amaperekedwa. pambuyo pobadwa, insulin mankhwala ikuchitika mwachizolowezi Mlingo. Panthawi yobereka, kuchepa kwakukulu kwa mlingo wa mankhwalawa omwe angagwiritsidwe ntchito kumachitika.

Kuchepetsa ndi kuyang'anira insulin kuphatikiza, chifukwa insulin imalowa mkaka wa m'mawere. Koma kusintha kwa mahomoni azimayi kumafuna muyeso wa glycemia komanso kusankhidwa kwa Mlingo woyenera.

Kuchita kwa insulin ndi mankhwala ena

Kuchita kwa insulin kumalimbikitsidwa ndikuphatikizidwa ndi mapiritsi ochepetsa shuga, beta-blockers, sulfonamides, tetracycline, kukonzekera kwa lithiamu, vitamini B6.

Bromocriptine, anabolic steroids. Hypoglycemia imatha kupezeka ndi kuphatikiza kwa insulin ndi ketokenazole, clofibrate, mebendazole, cyclophosphamide, ndi mowa wa ethyl.

Odwala ali ndi chidwi chofuna kuchepetsa insulin m'magazi. Nicotine, morphine, clonidine, danazole, kulera mapiritsi, heparin, thiazide okodzetsa, glucocorticosteroids, antidepressants ofanana, mahomoni a chithokomiro, sympathomimetics ndi calcium antagonists amatha kuchepetsa insulin.

Kanema yemwe ali munkhaniyi amafotokoza nthawi yomwe insulin ingafunikire komanso momwe mungabayire.

Zizindikiro zogwiritsidwa ntchito

• lembani matenda a shuga 1 mellitus (wodalira insulin),
• lembani matenda a shuga a 2 a mellitus (osadalira insulini): gawo la kukana kwa othandizira a hypoglycemic, osagwirizana ndi mankhwalawa (panthawi yophatikiza mankhwalawa), matenda osagwirizana, pakati.

Mlingo

Emeramine protamine-insulin adapangira utsogoleri wa SC. Mankhwala sangathe kulowa / kulowa.

Dokotalayo amawona mlingo wa mankhwalawa payekhapazokha, malinga ndi kuchuluka kwa shuga m'magazi. Pafupifupi, tsiku lililonse mlingo wa mankhwalawa umachokera ku 0,5 mpaka 1 IU / kg thupi, kutengera mtundu wa wodwalayo komanso kuchuluka kwa shuga.

Kutentha kwa insulin yoyenera kuyenera kukhala kutentha kwambiri. Emeramine protamine-insulin nthawi zambiri imayendetsedwa mwachangu mu ntchafu. Pamene s / c ikalowetsedwa mu ntchafu, mankhwalawa amamwiridwa pang'onopang'ono komanso moyenera kuposa jekeseni m'malo ena.

Zilonda zitha kupangidwanso m'chigawo cha minofu ya m'mapewa. Kupanga jakisoni pakhungu kumachepetsa chiopsezo cholowera minofu. Ndikofunikira kusintha malo a jekeseni mkati mwa anatomical dera kuti muchepetse kukula kwa lipodystrophy.

Pogwiritsa ntchito insulin kwambiri, chitetezo cha Protamine-Insulin Emergency chitha kugwiritsidwa ntchito ngati insal insulin 1-2 kawiri patsiku (madzulo ndi / kapena makonzedwe a m'mawa) osakanikirana ndi insulin yochepa, yomwe imayendetsedwa musanadye.

Mtundu wachiwiri wa matenda a shuga, matenda a Protamine-Insulin Emergency amatha kugwiritsidwa ntchito limodzi ndi mankhwala amkamwa a hypoglycemic ngati anthu sangadzipetse okha matenda ashuga.

Mimba komanso kuyamwa

Palibe choletsa pa chithandizo cha matenda osokoneza bongo a shuga ndi insulin panthawi yapakati, chifukwa insulin siyidutsa chotchinga. Mukakonzekera kukhala ndi pakati komanso panthawi imeneyi, ndikofunikira kulimbikitsa chithandizo cha matenda ashuga. Kufunika kwa insulin nthawi zambiri kumachepera mu trimester yoyamba ya kutenga pakati ndipo kumawonjezeka pang'onopang'ono kwachiwiri komanso kachitatu.

Nthawi yobadwa pambuyo pokhapokha ndipo mwayamba kubadwa, zofunika za insulin zimatha kugwa kwambiri. Pambuyo pobadwa, kufunikira kwa insulin kumabwereranso msanga momwe kunaliri asanakhale ndi pakati.

Palibe choletsa pa chithandizo cha matenda osokoneza bongo a shuga ndi insulin panthawi yoyamwitsa, monga Mankhwala a insulin kwa mayi amakhala otetezeka kwa mwana. Komabe, zingakhale zofunikira kuchepetsa mlingo wa insulini, chifukwa chake, kuyang'anira mosamala ndikofunikira mpaka pakufunika kwa insulin kukhazikika.

Protamine-insulin mwadzidzidzi, kuyimitsidwa kwa jekeseni 100me / ml - mndandanda - rup Belmedpreparaty

kanthu, insulin, mankhwala

Protamine insulin mwadzidzidzi: malangizo ogwiritsira ntchito ndi kuwunika - Against Diabetes

Kuyimitsidwa ndi koyera. Mukayimirira, kuyimitsidwa kumafanana ndikupanga chopanda utoto kapena chosakhala ndi utoto komanso choyera choyera, chomwe chimatha kukhala ndi zigamba zomwe zimayambitsidwa mosavuta ndikuyambitsa.

1 ml ya mankhwala ali: yogwira mankhwala: anthu chibadwa cha insulin 100 IU,

excipients: protamine sulfate 0,35 mg, sodium hydrogen phosphate dihydrate 2.4 mg, zinc chloride 0.018 mg, phenol 0.65 mg, metacresol 1.5 mg, glycerol (glycerin) 16,0 mg, madzi a jakisoni mpaka 1 ml .

Protamin insulinum

Kuchepetsa kuchuluka kwa shuga m'magazi, odwala matenda ashuga omwe ali ndi vuto lachiwiri la shuga amalimbikitsidwa kuti amwe mankhwala omwe angagwiritsidwe ntchito "Protamine-Insulin", omwe amathandiza kulimbana ndi glycemia. Mankhwalawa ali ndi zovuta komanso amathandizira thupi panthawi yamavuto yomwe amadumphadwala wama glucose ndipo amathandizira kupewa zovuta.

Kodi mankhwalawa ndi chiani?

Mankhwalawa adalandidwa ndi ukadaulo wama DNA obwerezabwereza ndipo ndi a ma insulin apakati. White jekeseni wamadzi amatha kukhala ndi mpweya womwe umasungunuka mosavuta ndikugwedezeka.

Mankhwala ndi oyenera omvera ambiri odwala.

Chifukwa cha kufatsa kwa mankhwalawa, mankhwala a insulin omwe ali ndi othandizira okhala ndi protamine amalola ana ndi akulu kuti azikhala ndi shuga wabwinobwino nthawi zingapo.

Zimagwira bwanji?

Kuchita kwa mankhwalawa kumadalira kuchuluka kwa kayendedwe ka glucose, chifukwa komwe kuchepa kwa shuga mumagazi kumachitika.

"Protamine-insulin" imayamba kugwira ntchito ola limodzi kapena awiri pambuyo pa utsogoleri ndipo zotsatira zake zimakhala mpaka maola 10-15. Mwa odwala ena, izi zitha kupitilira tsiku limodzi.

Popeza nthaka ndi gawo la mankhwala, mankhwalawo amatchedwa "Protamine-zinc-insulin." 1 ml yankho lili ndi magawo 40 a mahomoni.

Zisonyezero zogwiritsira ntchito "Protamine-Insulin"

Mankhwalawa atha kumwa anthu omwe ali ndi matenda amtundu uliwonse.

Mankhwalawa amalembedwa mtundu wa 2 ndi matenda ashuga 2. Ndikulimbikitsidwa kuti chitengedwe musanachite opareshoni, komanso kwa odwala omwe amadziwika kuti ali ndi matenda osokoneza bongo ndipo kusankhidwa kwa mankhwalawa kumachitika kuyambira pachiwopsezo.

"Insulin Zinc" imagwiritsidwa ntchito moyenera kuchepetsa shuga ndipo ndi yoyenera kwa anthu osowa kwenikweni kuthamanga kwa mankhwalawo. Ngati ndi kotheka, onjezerani mphamvu ya insulin yochepa, onse awiri amapaka jekeseni malinga ndi chiwembu chosankhidwa kuchipatala.

Momwe mungagwiritsire ntchito ndi kumwa?

Mankhwalawa amathandizidwa mosiyanasiyana mosagwirizana ndi malangizo a dokotala. Mlingo amawerengedwa payekhapayekha ndipo amatha kusintha pa nthawi ya chithandizo. Chizindikiro chapakati chimakhazikitsidwa pamlingo wa magawo a 0,5-1.0 patsiku. Kwa odwala matenda ashuga okhala ndi vuto laimpso komanso kwa chiwindi ndi odwala okalamba, Mlingo umadulidwa kuti mupewe zovuta.

Jekeseni amalimbikitsidwa mu ntchafu, m'mimba, kutsogolo, kapena matako. Ngati ndi kotheka, kuti mukwaniritse izi mwachangu, sankhani malo pamimba kapena ntchafu. Kuchepetsa machitidwe a mankhwalawa, imayikidwa m'manja. Zingwe ndizosavuta kuchitira nokha kunyumba. "Protamine" mukamayang'anira iyenera kukhala kutentha.

Kuti yankho lithe kutsamwa bwino komanso kusungunuka, ma bulou ayenera kugwedezeka asanalowe madziwo mu syringe.

"Protamine" imatha kubayidwa ndi ma insulin osakhalitsa kuti uthandizire kwambiri komanso kuwonjezera nthawiyo.

Kugwiritsa Ntchito Yapakati Ndi Unamwino

Mankhwalawa ndi otetezeka amayi oyembekezera.

"Protamine-insulin" ndiotetezeka kwa amayi omwe amabereka mwana chifukwa samadutsa placenta ndipo amangogwira thupi la mayi.

Njira ya mankhwala ndi mankhwala tikulimbikitsidwa kukula mu kukonzekera kutenga pakati ndi kubereka. Mu trimester yoyamba, Mlingo umachepetsedwa, monga mahomoni achilengedwe ochulukirapo amapangidwa.

Kenako kufunikira kwa insulin kumawonjezeka.

Panthawi yokonzanso pambuyo pathupi ndi mkaka wa m'mawere, mankhwalawo alibe zoletsa kuvomereza. Mlingo umasinthidwa ndi dokotala. Zinthu zomwe sizigwira ntchito sizimavulaza mwana wakhanda, koma chithandizo cha mayi chimayang'aniridwa ndi achipatala kuti apewe kupasuka komanso zovuta. Pakatha miyezi yochepa, kuchuluka kwa insulini ngakhale kutuluka.

Zovuta zotheka

Kafukufuku wachipatala amatsimikizira chitetezo cha mankhwalawa, zovuta zimachitika chifukwa cha kuphwanya kwa mulingo komanso chifukwa cha zomwe zimachitika pakhungu. Zotsatira zoyipa zimakhudza ma kupuma ndi endocrine.

Odwala amatha kukumana ndi kagayidwe kazakudya ndi zovuta mu kagayidwe kachakudya ka thupi, kusawona bwino. Chovuta chofala kwambiri ndikutupa pamalo a jakisoni. Kuti muchepetse iwo, ndikofunikira kusintha jakisoni wa mankhwalawo.

Zizindikiro zotsatirazi zingathenso kuchitika:

Vuto mutatha kumwa mankhwalawa limatha kukhala eczema.

• zotupa za pakhungu, chizungulire, zotupa za khungu,
• kuwoneka kupuma pang'ono, edema ya Quincke,
• palpitations, arrhythmia,
• mutu, kugwedeza, khungu lotuwa, njala ndi ludzu,
• hypoglycemia.

Kugwirizana kwina ndi zinthu zina

Mankhwala ena amathandizira kapena kufooketsa mphamvu ya mankhwalawo, zomwe zingayambitse kugwirira ntchito bwino. Kulimbitsa kumawonekera mukamatenga "Protamine" ndi othandizira ena a hypoglycemic, ma inhibitors ndi beta-blockers.

Zofananazo zimachitika mutatenga zosakaniza zomwe zimakhala ndi ethanol ndi lithiamu. Pofuna kuti pasakhale zovuta, wodwalayo ayenera kuyang'anira kuchuluka kwa shuga.

Ngati mukufuna kugwiritsa ntchito chinthu chosagwirizana pachiwopsezo, muyenera kufunsa dokotala.

Kudya zakudya zonunkhira kumakhudza mphamvu ya mankhwalawa.

Mphamvu ya hypoglycemic ya mankhwalawa imachepa limodzi ndi munthawi yomweyo kugwiritsa ntchito njira zakulera zam'mimba komanso estrogens, mankhwala okodzetsa, glucocorticosteroids, nikotini ndi morphines, komanso zinthu zina zingapo, mndandanda wathunthu wa zomwe zikuwonetsedwa mu malangizo a mankhwala. Zakudya zonunkhira ndi mowa zimatha kuthamanga ndikuyenda bwino kwa mankhwalawa. Zomwe zimakhudza chakudya zimakhudza munthu payekha.

Mitu ya mankhwalawa

Posinthira kwakanthawi kapena kwathunthu kwa mankhwala, ma insulin ofanana omwe amagwiritsidwa ntchito amagwiritsidwa ntchito, monga Iletin II NPH, Neosulin NPH, Monodar B.

Kulowa m'malo mwa mankhwala ochiritsira kumachitika pang'onopang'ono. Kuphatikiza mankhwala awiri kapena angapo ofanana pa mlingo umodzi ndiwothandiza kupewa. Dokotala ayenera kusankha choloweza mmalo.

Kusintha kosaloledwa kuchokera ku chinthu chimodzi chamankhwala kupita kwina kumakhala pachiwopsezo cha zovuta ndi thupi lonse.

Protamine insulin mwadzidzidzi: malangizo ogwiritsa ntchito ndi kuwunika

Chithandizo cha matenda a shuga chimachitika pogwiritsa ntchito mankhwala omwe, pakakhala kuti apanga mahomoni awoawo (insulin), amatha kutsika magazi kwambiri komanso kupewa mavuto a matendawa.

Mankhwala onse amatha kugawidwa m'magulu awiri akuluakulu: ma insulini osiyanasiyana olimbitsa thupi ndi mankhwala oikidwa. Mtundu woyamba wa matenda ashuga, odwala amafunikira insulin, chithandizo cha odwala omwe ali ndi matenda a shuga 2 chimaphatikizira kuphatikizidwa kwa mankhwalawa pamaso pa anthu omwe akuwonetsa.

Kuchita mankhwala a insulini kumaberekanso mtundu wina wachilengedwe wopanga ndi kumasulidwa kwa timadzi tating'onoting'ono ta zikondamoyo, motero, mankhwala omwe ali ndi yochepa, yapakati komanso yayitali amachita.