Kukonzekera kwa Thioctic acid: mndandanda, mayina, mawonekedwe omasulidwa, cholinga, malangizo, ntchito, zisonyezo ndi zotsutsana

M'nkhaniyi, tikambirana za kukonzekera kwa thioctic acid.

Thioctic (α-lipoic) acid imatha kumanga ma radicals omasuka. Kapangidwe kake m'thupi kumachitika nthawi ya oxidative decarboxylation ya α-keto acid. Imagwira nawo mu oxidative ndondomeko ya decarboxylation ya α-keto acid ndi pyruvic acid monga enzyme ya mitochondrial multienzyme complexes. Mwakuchita kwake kwachilengedwe, zinthuzi zili pafupi ndi mavitamini a B. Kukonzekera kwa Thioctic acid kumathandizira kusintha ma neurophylon, kutsika kwa glucose, kuonjezera kuchuluka kwa glycogen mu chiwindi, kuchepa kwa insulin, kusintha chiwindi, komanso kuchita nawo mwachindunji pakumanga kwa lipid ndi carbohydrate metabolism.

Pharmacokinetics

Mukamamwa pakamwa, thioctic acid imatengedwa mwachangu. Mu mphindi 60, imafika poipa kwambiri m'thupi. The bioavailability wa chinthu 30%. Pambuyo mtsempha wa magazi mankhwala thioctic acid 600 mg pambuyo mphindi 30, pazotheka plasma ambiri.

Metabolism imachitika m'chiwindi kudzera makutidwe ndi ma oxide am'mbali ndi kuphatikizika. Mankhwala ali ndi vuto loyambanso kulowa m'chiwindi. Hafu ya moyo ndi mphindi 30-50 (kudzera impso).

Kutulutsa Fomu

Thioctic acid imapangidwa mumitundu yosiyanasiyana ya mitundu, makamaka mwanjira ya mapiritsi ndi kulowetsedwa. Mlingo umasiyananso kwambiri kutengera mtundu wa mankhwalawo amasulidwe komanso mtundu wa mankhwalawo.

Zizindikiro zogwiritsira ntchito kukonzekera kwa thioctic acid zimafotokozedwa mwatsatanetsatane mu malangizo. Amalembera odwala matenda ashuga ndi mowa.

Contraindication

Mndandanda wa zotsutsana ndi chida ichi chikuphatikiza:

• lactose kusalolera kapena kulephera,
• galactose ndi shuga malabsorption,
• kuyamwa, kutenga pakati,
• osakwana zaka 18
• chidwi chachikulu pazigawo.

Mothandizidwa ndi mtsempha wa magazi amayenera kuchitika mosamala kwa anthu atatha zaka 75.

Malangizo ogwiritsira ntchito

Kukonzekera kwa Thioctic acid mu mawonekedwe a mapiritsi kumatha, mphindi 30 musanadye kadzutsa, ndi madzi. Mlingo woyenera ndi 600 mg kamodzi tsiku lililonse. Mapiritsi amayamba pambuyo pa makolo awo 2-2 milungu. Njira yayitali kwambiri yodalirika yopitilira masabata 12. Chithandizo chautali chitha kuchitika malinga ndi dokotala.

The kuganizira kwambiri kulowetsedwa njira imayendetsedwa kukapanda kuleka m`nsinga pang'onopang'ono. Njira yothetsera vutoli iyenera kukonzedwa nthawi yomweyo isanakwane kulowetsedwa. Zomwe zakonzedwerazi ziyenera kutetezedwa ku dzuwa, pamenepa zitha kusungidwa mpaka maola 6. Njira yogwiritsira ntchito mankhwalawa ndi masabata 1 mpaka 4 kenako mutasinthira piritsi.

Ndi njira iti yokonzekera thioctic acid yomwe ili bwinonso yosangalatsa kwa ambiri.

Zotsatira zoyipa

Zochitika zotsatirazi zam'magazi zimawoneka ngati zoyipa mukamagwiritsa ntchito mankhwalawa:

• kusanza, kusanza, kutsegula m'mimba, kupweteka pamimba, kutentha kwa mtima,
• thupi lawo siligwirizana (zotupa pakhungu, kuyabwa), mantha anaphylactic,
• kuphwanya kukoma
• hypoglycemia (thukuta kwambiri, cephalalgia, chizungulire, masomphenya osalongosoka),
• thrombocytopathy, phenura, petechial kukha kwa mucous nembanemba ndi khungu, hypocoagulation,
• autoimmune insulin syndrome (mwa anthu odwala matenda ashuga),
• kutentha kwa moto, kukokana,
• kuchuluka kwa michere yokugaya,
• kupweteka mu mtima, ndi kuyambitsa mwachangu kwa pharmacological wothandizira - kuchuluka kwa mtima,
• thrombophlebitis
• diplopia, masomphenya osalala,
• kusapeza bwino pa jekeseni malo, hyperemia, kutupa.

Ndi makonzedwe achangu a mankhwalawa, kupanikizika kwa intracranial (kudutsa palokha) kumatha kuchuluka, kupuma movutikira komanso kufooka kumachitika.

Mankhwala okhala ndi Acid iyi

Mankhwala otsatirawa ndi omwe amakonda kwambiri thioctic acid:

• Mgwirizano.
• "Lipothioxone."
• Oktolipen.
• "Thioctacid."
• "Neyrolipon".
• Sitimay.
• "Ndale".
• Tielepta.
• Espa Lipon.

Mankhwala "Berlition"

Chofunikira kwambiri pamankhwala awa ndi alpha-lipoic acid, chomwe ndi chinthu chokhala ndi Vitamini chomwe chimagwira ntchito ya coenzyme pakupanga kwa oxidative decarboxylation wa alpha-keto acid. Ili ndi antioxidant, hypoglycemic, neurotrophic. Kuchepetsa kuchuluka kwa sucrose m'magazi ndikuwonjezera kuchuluka kwa glycogen m'chiwindi, kumachepetsa insulin. Kuphatikiza apo, gawoli limayendetsa kagayidwe ka mafuta ndi chakudya, limalimbikitsa kagayidwe ka cholesterol.

Odwala omwe ali ndi matenda osokoneza bongo a mtundu uliwonse, asidi wa thioctic amasintha kuchuluka kwa asidi m'magazi, amalepheretsa kutsika kwa glucose wama protein mapuloteni komanso kupanga mapangidwe omaliza a glycosation. Kuphatikiza apo, asidiyo amalimbikitsa kupanga glutathione, imapangitsa ntchito ya chiwindi kwa odwala omwe ali ndi hepatic pathologies ndi mawonekedwe a zotumphukira dongosolo la odwala omwe ali ndi matenda a shuga a polyneuropathy. Kutenga nawo kagayidwe ka mafuta, thioctic acid imatha kulimbikitsa kupanga ma phospholipids, chifukwa chomwe ma membrane am'mimba amabwezeretsedwa, mphamvu ya metabolism ndi kutumiza kwa mitsempha imakhazikika.

Mankhwala "Lipothioxone"

Kukonzekera kwa thioctic acid ndi mtundu wa antioxidant wam'mbuyo womwe umamangirira zopitilira muyeso. Thioctic acid imagwira ntchito kwambiri mu mitochondrial metabolism mu cell, ndipo imagwira ngati coenzyme pakusintha kwa zinthu ndi zotsatira za antitoxic. Amateteza maselo ku ma radicals omwe amapezeka pakasinthanitsidwa kapena kuwonongeka kwa zinthu zakunja, komanso pogwiritsa ntchito zitsulo zolemera. Kuphatikiza apo, chinthu chachikulu ndi synergistic pokhudzana ndi insulin, yomwe imalumikizidwa ndi kuwonjezeka kwa kugwiritsira ntchito shuga. Mu odwala matenda ashuga, thioctic acid amalimbikitsa kusintha kwa kuchuluka kwa magazi a pyruvic acid.

Mankhwala "Oktolipen"

Awa ndi mankhwala ena omwe amachokera ku thioctic acid - coenzyme yamagulu angapo a mitenzondime a multenzyme, omwe amatenga nawo gawo la oxidative decarboxylation a α-keto acid ndi pyruvic acid. Ndi antioxidant wamkati: amachotsa zopitilira muyeso, kubwezeretsa milingo yama glutathione mkati mwa maselo, kumawonjezera magwiridwe a superoxide dismutase, axonal conductivity ndi trophic neurons. Imagwira gawo lofunikira mu metabolism ya mphamvu, imakhala ndi lipotropic, ndikuwongolera ntchito ya chiwindi. Imakhala ndi mphamvu pobweretsa poizoni wazitsulo komanso kuledzera.

Malangizo apadera ogwiritsira ntchito mankhwala

Pa chithandizo cha mankhwala osokoneza bongo a thioctic acid, munthu ayenera kupewa kumwa mowa. Odwala omwe ali ndi matenda ashuga amafunika kuwunika pafupipafupi kuchuluka kwa shuga m'magazi, makamaka munthawi ya kugwiritsa ntchito mankhwala enaake. Pofuna kupewa kukula kwa hypoglycemia, kusintha kwa insulini kapena mankhwala a pakamwa a hypoglycemic kungakhale kofunikira. Ngati zizindikiro za hypoglycemia zikuchitika, kugwiritsa ntchito asidi wa thioctic kuyenera kuyimitsidwa nthawi yomweyo. Amathandizanso pa milandu ya hypersensitivity reaction, mwachitsanzo, kuyabwa pakhungu ndi khungu.

Kugwiritsa ntchito mankhwala pa mimba, mkaka wa m`mawere ndi ana

Malinga ndi kufotokozeredwa kwa kugwiritsa ntchito mankhwala okhala ndi thioctic acid, mankhwalawa amatsutsana panthawi yapakati komanso mkaka wa m`mawere. Kukhazikitsidwa kwa ndalama izi muubwana kumapangidwanso.

Kuyanjana kwa mankhwala osokoneza bongo

Ndikofunikira kuti muzisunga nthawi yochepera maola 2 mukamagwiritsa ntchito mankhwala a thioctic acid omwe ali ndi zitsulo, komanso zinthu zamkaka. Kugwiritsa ntchito kwambiri kwa asidi kumayesedwa ndi zinthu zotsatirazi:

• cisplatin: mphamvu yake imachepa
• glucocorticosteroids: kukulitsa mphamvu yawo yotsutsa-kutupa,
• Mowa ndi metabolites: kuchepetsa kukhudzana ndi thioctic acid,
• m`kamwa hypoglycemic mankhwala ndi insulin: zotsatira zake zimatheka.

Mankhwalawa mu mawonekedwe amomwe amathandizira pakukonzekera kulowetsedwa sikugwirizana ndi mayankho a dextrose, fructose, yankho la Ringer, komanso ndi mayankho omwe amachitika ndi magulu a SH- komanso osagwirizana.

Mtengo wa mankhwalawa

Mtengo wamankhwala okhala ndi thioctic acid umasiyana mosiyanasiyana. Mtengo wa mapiritsi 30 ma PC. Mlingo wa 300 mg ndi wofanana - ma ruble 290, ma 30 ma PC. Mlingo wa 600 mg - 650-690 rubles.

Kukonzekera kwabwino kwa thioctic acid kumathandiza dokotala kusankha.

Ndemanga za mankhwala

Ndemanga za mankhwalawa zabwino. Akatswiri amayamikirira kwambiri momwe amathandizira ngati opatsirana komanso antioxidant ndipo amalimbikitsa kugwiritsa ntchito anthu omwe ali ndi matenda ashuga komanso mitundu yama polyneuropathies. Odwala ambiri, nthawi zambiri azimayi, amamwa mankhwalawa kuti achepetse thupi, koma malingaliro amagawidwa pazoyenera za mankhwalawa kuti achepetse thupi. Mtengo wokwera wa mankhwalawa umawonedwanso.

Malinga ndi ogula, mankhwala amasunthidwa bwino kwambiri, zotsatira zoyipa sizichitika kawirikawiri, ndipo pakati pawo zimachitika kawirikawiri zimawonedwa, zomwe nthawi zambiri zimakhala zofatsa, zizindikiro zimatha paokha atayimitsa mankhwalawo.

Tinakambirana mndandanda wa kukonzekera kwa thioctic acid.