Alpha Lipoic Acid wa Matenda A shuga

-1 '£ pi ® Kuchita Endocrinologist

1-1 / Kuchita Endocrinologists /

Nyuzipepala yapadziko lonse ya endocrinology

Chiyukireniya cha Sayansi Yothandiza ndi Chiwonetsero cha Endocrine Opaleshoni, Kuthana kwa Endocrine Organs ndi Matupi a Ministry of Health of Ukraine, Kiev

ALPHA-LIPOIC ACID MU DIABETIC NEUROPATHY

Kuzindikira ndi pathogenesis ya matenda ashuga

Diabetesic neuropathy (DN) ndi zovuta pama syndromes azachipatala komanso amtundu uliwonse, womwe umadziwika ndi zotupa kapena zotumphukira za zotumphukira chifukwa cha matenda osokoneza bongo a mellitus.

Kuzindikira koyambirira komanso chithandizo chokwanira cha matenda ashuga a m'mimba ndikofunikira kwambiri chifukwa cha zinthu zingapo. Neuropathy ndi imodzi mwazinthu zofunikira kwambiri zowonjezera chiwopsezo cha matenda a shuga (SDS), omwe, pomwepo, angayambitse kufunika kokadula malekezero akumunsi. Nthawi zambiri, DN imakhala asymptomatic, koma imadziwiratu microtraumatization ndi kapangidwe kakang'ono ka zilonda zapambuyo. Zinawonetsedwa kuti 80% ya odwala omwe ali ndi matenda ashuga omwe amadulidwa kumapeto ochepa anali ndi mbiri yovulala kapena zilonda zamapazi.

Odwala omwe ali ndi matenda ashuga, kukulira kwa ma neuropathies osachokera ku matenda ashuga ndi kotheka, komwe kumapangitsa kufunikira kwa kuzindikira koyenera.

Mitundu yodziwika bwino ya DN ndi sensory-motor distal symmetric polyneuropathy ndi autonomic (visceral, autonomic) neuropathy. Tanthauzo lotsatira la matenda ashuga polyneuropathy (DPN) amadziwika ponseponse: kupezeka kwa zizindikiro ndi / kapena cholinga chakuwonongeka kwa mitsempha mwa anthu omwe ali ndi matenda ashuga popanda zifukwa zina. Chifukwa chake, si odwala onse omwe ali ndi zowonongeka m'mitsempha yamagazi chifukwa cha matenda ashuga. Ndiye kuti, kupezeka kwa matenda ashuga ndi kudziwa kupatulidwa. Komabe, DN imatha kupezeka mwa odwala popanda chiwonetsero chilichonse chachipatala. Pankhaniyi, kuzindikira kuyenera kuzindikiritsa zisonyezo zowonongeka mu zotumphukira zamanjenje.

Mawonetseredwe a kuchipatala a sensor-mota DPN ndi awa: ululu (womwe nthawi zambiri umakhala ukuyaka kwambiri usiku,

stesia, hyperesthesia, kuchepa kwa chidwi - kugwedezeka, kutentha, kupweteka, matalala, kuchepa kapena kuchepa kwa zinthu zolimbitsa thupi, khungu lowuma, kutentha kapena kuchepa, kukhalapo kwa osadandaula m'malo opsinjika kwambiri. Iyenera kutsimikiziridwa kuti madandaulo a neuropathy amawonetsedwa mu theka la odwala, ndipo mwa odwala omwe atsala, neuropathy ndi asymptomatic.

Kuzindikiritsa kwa DPN kumapangidwa pamaziko a zidziwitso zamankhwala popanda kupatula zina zomwe zimapangitsa kuwonongeka kwamanjenje (makamaka kusowa kwa vitamini B12, hypothyroidism, kulephera kwa aimpso. DN ndi zovuta kwambiri zamtundu 1 wa matenda ashuga.

The pafupipafupi neuropathy odwala matenda a shuga, malinga ndi ofufuza osiyanasiyana, kuyambira 5 mpaka 90%, kutengera zaka, nthawi yayitali ya matenda, kuopsa kwa matenda ashuga komanso njira zodziwikira. Chifukwa chake, pamene electromyography imagwiritsidwa ntchito pozindikira zotumphukira sensorimotor DN, kuchuluka kwa DN kumawonjezeka ndikufika 70-90%. Komabe, zotsutsana zotsutsana ndi DNs zimapezeka kawiri kawiri m'mabuku, kutsimikiza kwake komwe kumakhala chifukwa chazidziwitso zosiyanasiyana komanso zosakwanira zomwe zimapezeka ndi mitundu yosiyanasiyana yazachipatala, kusapezeka kwa njira zogwirizana zopezera zotumphukira za neuropathy, komanso kufufuza kwa odwala osiyanasiyana.

Zina mwazinthu zomwe zimatchedwa DN, matenda a hyperglycemia ndi ofunika kwambiri. Udindo wotsogola wa hyperglycemia umatsimikiziridwa ndikuti pafupipafupi ma neuropathy odwala omwe ali ndi matenda amtundu wa 1 ndi mtundu wa 2 ali ofanana. Ngakhale pathogenesis yamtunduwu wa shuga ndi yosiyana, mawonekedwe awo wamba ndi hyperglycemia ndikuchepetsedwa

Adilesi yolumikizirana ndi wolemba:

Pankiv Vladimir Ivanovich Imelo: [email protected]

ny mphamvu ya insulin. Kubwezeretsedwa kwa shuga kwa nthawi yayitali kumayendetsa bwino njira ya DM ndikuthandizira kutsika kwakukulu pamafupipafupi a izi. Izi zikuwatsimikiziridwa motsimikizika ndi zotsatira za kafukufuku woyembekezeredwa wazaka zambiri ndi DCCT (The Diabetes Control and Complication T kesi), pomwe odwala omwe amalipidwa ndi matenda amtundu wa shuga wa 1 adakwanitsa kuchepetsa kwakukulu muzochitika za DN (pofika 70%) poyerekeza ndi odwala omwe anali kubwezeredwa kwa matenda ashuga.

Masiku ano, kuchokera pa lingaliro la pathogenetic, DN iyenera kuonedwa ngati gawo lophatikizika la zochitika zomwe zimapangitsa kukula kwa glucose kukhala gawo lalikulu. Matenda amitsempha yamagazi am'mimba chifukwa cha microangiopathy, kuperewera kwa oxidative, kuperewera kwa njira ya polyol glucose ndi mapangidwe a sorbitol, mowa woopsa womwe umawononga mafupa am'mitsempha, komanso kutupa kosatha ndi ma genetic (Mollo R. et al., 2012) akuphatikizidwa ndi pathogenesis ya DN. .

Kuphatikiza apo, zomwe zimayambitsa chitukuko cha DN zonsezi ndi kuwonongeka kwa kagayidwe kazakudya komanso nthawi yayitali ya matendawa, ukalamba, mbiri ya chikomokere, kunenepa kwambiri, matenda oopsa, hypercholesterolemia, proteinuria. Kulephera kwa impso ndi uremia, komanso matenda ena ophatikizika (chiwindi, hypothyroidism, kuchepa kwa magazi, zotupa, kuchepa kwa Vitamini B, matenda amtundu wamatenda ndi matenda ena obadwa nawo) ndi kuledzera (uchidakwa) kungayambitse kukula kwa kuwonongeka kwa dongosolo lamanjenje mu shuga.

Mwambiri, titha kuwaona ngati DN ndi matenda omwe amachitika ndi matenda ashuga, omwe amatsogolera kuwonongeka m'moyo wamtundu ndikuwonjezera kufa kwa odwala. Mtengo wokwera kuchiritsa anthu ndi zotupa zotere umachitika chifukwa cha matenda osadziwika bwino, chifukwa nthawi zambiri ma DN amadziwika kale pamasinthidwe osasinthika komanso zizindikiro zotchulidwa. Chifukwa chake, chithandizo cha DN chiyenera kuyamba kuyambira nthawi yayitali isanayambike zizindikiro zake zoyambirira.

Pali lingaliro lakale kuti shuga imayambitsa chitukuko cha DN pokhapokha patatha zaka zambiri za hyperglycemia. Komabe, malinga ndi malembawa, pafupifupi wodwala aliyense wachisanu yemwe wapezeka ndi matenda ashuga tsopano amapezeka ndi DN malinga ndi zotsatira za kafukufuku wamagetsi, pomwe matenda ashuga retinopathy ndi nephropathy palibe.

Chithandizo cha matenda ashuga a Neuropathy

American Pharmacological Committee (FDA - Food and Drug Administration) yakonza njira zina zamankhwala zomwe zingalembetsedwe ngati mankhwala othandizira DN: zotsatira pamachitidwe a pathogenetic, kuchepetsedwa kwa zizindikiro za neuropathy, kusintha kwa ntchito ya mitsempha, kusowa kwa zotsatira zoyipa, kuchepetsa chiopsezo cha kufa kwa mitsempha ya mitsempha .

Mpaka pano, m'maiko ambiri, mankhwala a mzere woyamba wochizira DN, malinga ndi protocol, kuchipatala, ndi thioctic, kapena alpha-Li-poic acid (ALA).

Ichi ndi chimodzi mwazinthu zomwe zidagwiritsidwa ntchito bwino kuthana ndi mavuto omwe afotokozedwa pamwambapa. Kukhala mwachilengedwe metabolite wachilengedwe (mankhwala a metabolic), ALA imakhudzidwa ndi njira zambiri zokhudzana ndi metabolism, ndipo ndi njira yothandiza kwambiri ya pharmacotherapy yogwiritsira ntchito metabolism. ALA ili ndi zotsatirapo zosiyanasiyana zachilengedwe komanso zamankhwala. Ichi ndi chifukwa chake kutenga nawo mbali monga gawo lofunika la mphamvu ya kapangidwe kazinthu pakusintha ma organic acid, zomwe zimathandiza kuchepetsa kuchuluka kwa acid m'maselo. Polimbikitsa mapangidwe a coenzyme A (CoA), imakhudzidwa ndi metabolism yamafuta acids.Izi limodzi ndi kuchepa kukula kwa mafuta kuwonongeka kwa chiwindi maselo, kutsegula kwa kagayidwe kachakudya ntchito ya chiwindi ndi bile katulutsidwe, amene amapereka hepatoprotective kwambiri. Kuphatikiza apo, ALA imathandizira kukhathamiritsa kwa mafuta acids, kuchepetsa kuchuluka kwa ma lipids am'magazi, kumakhala ndi antioxidant katundu, ndiye kuti, imalepheretsa ma radicals aulere omwe amawononga khungu. Amachepetsa kukananso kwa insulin kwa maselo amthupi, omwe amafunikira kwambiri shuga.

Zoposa theka la zaka zapita kuchokera pomwe lipoti loyamba mu 1955 lidagwiritsidwa ntchito pochiritsa ALA ku Tokyo. Zomwe zikuchitika padziko lonse lapansi komanso kugwiritsa ntchito mankhwala a ALA popita ku zipatala zotsogola zapangitsa kuti anthu azindikire kuti ndi othandiza kwambiri matenda ambiri omwe amapezeka mu endocrinology, urology, toxology, sexopathology, gastroenterology, opaleshoni ndi hepatology. Maphunziro azachipatala ambiri atsimikizira kukwera kwambiri kwa ALA pochiza zotupa za matenda ashuga - matenda am'mimba a shuga a shuga. Kuchita bwino kwa mankhwalawa kwa mankhwala a ALA mu zotupa zam'mimba za chiwindi kumachitika chifukwa choganizira momwe amapangira matendawa komanso kuthekera kokuchulukana kwambiri pakuphatikizika kwamitsempha yamitsempha. Kuphatikiza pa metabolic neuropathy, mphamvu yotchulidwa ya ALA imadziwika mu mitundu yosiyanasiyana ya zakumwa zoledzeretsa (zakumwa zoledzeretsa, zakunja, zamkati) komanso matenda ena angapo.

Maziko a neuroprotective (kuteteza minofu ya mitsempha) ndichakuti ALA "imathandizira kusintha kagayidwe kamatenda m'maselo amitsempha ndipo imathandiza pa kayendedwe ka axonal.

ALA ndi mankhwala achilengedwe oletsa antioxidant komanso othandizira antioxidant omwe amagwira ntchito pa membrane komanso cell cytoplasm. Ndi kutenga nawo mbali

ALA imasinthanso ndikubwezeretsa ma antioxidants ena mthupi kudzera pakukhudzana ndi minyewa glutathione ndi ubiquinone. Kupadera kwapangidwe kamapangidwe amakanidwe a ALA kumalola kuti kukonzanso kukonzanso kwa ma cell aokha mosasamala, osatenga nawo mbali pazinthu zina.

ALA amathanso kuchita ngati coenzyme ya maofesi a multenzyme a oxidative decarboxylation a pyruvic ndi alpha-keto acid (alpha-ketoglutarate ndi nthambi za alpha-keto). ALA imayendetsa pyruvate dehydrogenase ndipo imalepheretsa carboxylase, imagwira ntchito yofunika kwambiri pakupanga mphamvu (adenosine triphosphate), potero kuchepetsa kuchepa kwa mphamvu mu minofu.

Kuchepa kwa kuopsa kwa zizindikiro za DN panthawi yamankhwala omwe ali ndi ALA kungakhale chifukwa chakuyenda bwino kwa magazi m'magazi amkati pamankhwala.

Zotsutsa-zotupa za ALA zimatsimikiziridwa pano. Chifukwa chake, ALA imalepheretsa zochitika ndi cytotoxicity ya maselo a NK, chithandizo ndi ALA chimachepetsa kuchuluka kwa ma interleukin-6 ndi -17 (IL-6, IL-17), kuchuluka kwa T-cell (pofika 90%).

Katundu wachilendo wa ALA anali luso lotha kugwiritsa ntchito minofu ya minyewa. Izi zimayenderana ndi phosphorylation ya tyrosine zotsalira za insulin receptors, kutsegula kwa glucose onyamula GLUT-1 ndi GLUT-4, ndi zovuta zina zingapo pazovuta zodalira insulin. Pakufufuza koyendetsedwa ndi placebo, S. Jacob et al. (1999) adawonetsa kuti kuwonjezeka kwa insulivivity kwa odwala omwe ali ndi matenda amtundu wa 2 amawonedwa pambuyo pa masabata 4 a kukonzekera kwa pakamwa kwa ALA (600 mg) 1, 2 kapena katatu patsiku. H. Ansar et al. (2011) adawonetsa kuchepa kwakukulu kwa kusala komanso postprandial glycemia, kusintha pakulimbana ndi insulin pagulu la odwala omwe ali ndi matenda a shuga 2 omwe alandila ALA kwa miyezi iwiri pa mlingo wa 300 mg patsiku.

Kuwongolera mbiri ya glycemic ndikuwonetsa kuchepa kwa makulidwe a oxidative adawonetsedwa mu kafukufuku wosasinthika, wakhungu lachiwiri, wokhazikika kwa odwala omwe ali ndi matenda a shuga a 2 omwe amathandizidwa ndi mitundu yambiri ya ALA (300, 600, 900 ndi 1200 mg / tsiku).Pambuyo pa miyezi isanu ndi umodzi, gulu lazachipatala linawonetsa kuchepa kwa glycemia ndi glycated hemoglobin (HbA1c), kuchuluka kwa kuchepa kudalira mlingo wa ALA. Urinary Excretion PGF2 IsoP (prostaglandin F2-alpha-isoprostane) anali ochepa m'magulu azithandizo kuposa gulu la placebo. Olembawo amaganiza kuti kugwiritsa ntchito ALA kumalumikizidwa ndi glycemia yowonjezera komanso kupsinjika kwambiri kwa oxidative nkhawa (Porasuphatana S. et al., 2012).

Kuthandiza kwa ALA pochiza DN kwatsimikiziridwa mu maphunziro a ALADIN (Alpha-Lipoic Acid mu Diabetesic Neuropathy - Alpha Lipoic Acid a Diabetesic Neuropathy) ndi DECAN (Deutsche Kardiale Autonome Neuropathie - Kafukufuku wa Germany wa mtima wa neuropathy.

Kafukufuku wa ALADIN ndidazindikira njira yabwino kwambiri yochizira alpha-lipoic acid - 600 mg kudzera m'mitsempha (mphamvu ya m'munsi mlingo (100 mg) akuyerekeza ndi zotsatira za placebo) ndi kuchepa kwa ululu, kumva kupsa, kumva dzanzi. Kafukufuku wina (ALADIN II) adatsimikizira kuti kayendetsedwe kamlomo ka ALA pamtunda wa 600 kapena 1200 mg kwa zaka ziwiri (pambuyo pa masiku asanu osakwanira ndi makonzedwe a mtsempha) kumapangitsa ntchito yamitsempha, ndikuwonjezera kuthamanga kwa kukhudzidwa kwa mitsempha. Nthawi yomweyo, 89% ya odwala omwe ali mgululi omwe amalandira 600 mg ndi 94% pagululi omwe amalandila 1200 mg ya ALA kwa zaka ziwiri adavomereza kulolerana kwa mankhwalawa ngati abwino komanso abwino kwambiri. Olembawo adatsimikiza kuti kulekerera kwa mankhwala pakapita nthawi yayitali kumafanana ndi placebo. Kafukufuku wa ALADIN adawonetsa kuti kukhazikika kwa mtundu wa 2 ALA kwa odwala omwe ali ndi matenda ashuga (600 ndi 1200 mg kwa masabata atatu) kumafooketsa zizindikiro zamatenda a DN: kupweteka, kutentha, dzanzi, paresthesia. Kafukufuku wa DECAN adatsimikizira kuthekera kwa ALA (800 mg / tsiku pakamwa kwa miyezi inayi) kuchepetsa ziwonetsero za mtima za autonomic DN, makamaka, kuwonjezera kusinthasintha kwa mtima.

Pambuyo pake, zotsatira za kafukufuku wina wazachipatala komanso zotsatsa zotsatsa adasindikizidwa zomwe zimatsimikizira kugwira ntchito kwa ALA. Zambiri zofunikira zimapezeka pa kafukufuku wa ALADIN II. Mkati mwa polojekitiyi, zidawonetsedwa kuti chithandizo cha pakamwa chamtali ndi ALA (600 kapena 1200 mg kwa zaka ziwiri) sichimalola kokha kuwongolera zizindikiro za zotumphukira DN, komanso kukonza magawo amagetsi a ntchito ya mitsempha. Kafukufukuyu adakuwona mbiri yayikulu ya chitetezo cha ALA: pafupipafupi zotsatira zoyipa mwa iwo omwe amamwa mankhwalawo komanso mu gulu la placebo zinali zofanana.

Zokondweretsa ndizotsatira za kafukufuku wa ALADIN III. Mphamvu ya mankhwalawa idaphunziridwa mwa odwala 509 omwe ali ndi matenda a shuga a 2 omwe ali ndi zotumphukira DN. Pambuyo popita jakisoni wambiri (600 mg / tsiku kwa masabata atatu), chithandizo chinapitilizidwa mpaka miyezi isanu ndi umodzi - kumwa ALA pakamwa pa 1800 mg / tsiku, zomwe zimathandizira kuphatikiza zabwino zomwe zinakwaniritsidwa ndikuwongolera magawo a mitsempha.

Malinga ndi kafukufuku wa ORPIL (ORal PILot Study), kuyamwa kwamankhwala akuluakulu a ALA (1800 mg / tsiku kwa masabata atatu) kumayendetsa bwino zizindikiro za zotumphukira za DN popanda kukhazikitsa mankhwala.

Kuyesa zotsatira za nthawi yayitali, kwa zaka zinayi, kugwiritsa ntchito mankhwala a ALA pakamwa pa kupitirira kwa DN, kuphatikiza mitundu yambiri, khungu lowongolera lolumikizidwa ndi NATHAN I (Neurological kupima kwa THioctic Acid mu matenda ashuga a Neuropathy - Neurological kuwunika kwamomwe ththic acid imayendera matenda ashuga). Phunziroli lidaphatikizapo odwala omwe ali ndi matenda a shuga a mtundu woyamba 1 komanso matenda a shuga a 2. Mu mphamvu (zotsatira zoyambirira) akuti

ngati panali kusintha kwa chisonyezo chophatikizidwachi, kuphatikiza zopitilira muyeso wa NIS (Neuropathy Imruptment Score LL (Ziphuphu Zotsika - miyendo yam'munsi), komanso mayeso 7 owonjezera a mitsempha yodzetsa (Dyck PJ et al., 1997) .Mapeto a sekondale anaphatikiza mamasukulu ku NIS, masikelo a NIS, NIS -LL, NSC (Neuropathy Syndromeom and Change), TSS (Total Syndromeom Score), kuwunika kwa kutentha ndi zidziwitso zamagetsi. Zotsatira zake zidawunikidwa pambuyo pa zaka 2 ndi 4 za chithandizo.Kusiyana kwakukulu pakati pamaguluwo kunawonedwa patatha zaka 4 molingana ndi NIS ndi NSC: pagululi mankhwalawa adasintha kukonzekera kwa gulu la placebo - zoyipa akonzedwa. Mu gulu la Ala komanso kwambiri utachepa minofu kufooka. An kuwonjezeka kuchuluka kwa odwala kuyankha bwino chithandizo mu yogwira mankhwala gulu poyerekeza placebo.Kafukufukuyu adawonetsa kuti chithandizo cha nthawi yayitali ndi ALA chimathandizira njira ya DN, makamaka mawonekedwe a minyewa yaying'ono yamitsempha ndi minofu ntchito.

Kafukufuku wokhudzidwa ndi matenda a meta-ALADIN, SYDNEY (Sy daliliomatic Diabetesic NEuropathY mayesero), ORPIL, SYDNEY2, ndi ALADIN III (2011) adawonetsa kusintha kwa zizindikiro za mitsempha ndi ALA yamitsempha poyerekeza ndi placebo. Kusintha kwakukulu kunadziwika ndi kuphatikiza kwa parenteral (600 mg patsiku kwa masabata atatu) ndi mankhwala amkamwa (600 mg katatu patsiku kwa miyezi 6). Mlingo wa 600 ndi 1200 mg patsiku unawonetsa ntchito imodzimodzi, koma mlingo wa 1200 mg unalumikizidwa ndi zovuta zambiri zoyipa. M'maphunziro onse, kuchepa kwakukulu kwa zizindikiro za DN kudawonetsedwa. Zinadziwika kuti kafukufuku wa NATHAN I adawonetsa kupita patsogolo kwa DN m'gululi la placebo komanso kusintha kwazomwe zimachitika mu gulu lazitali la ALA.

Ndizosangalatsa kuti odwala omwe ali ndi DN pambuyo pokonzekera kulowetsedwa kwa ALA pamtunda wa 600 mg kwa masabata atatu, kusintha kwa mawonetsedwe amitsempha kumatenga nthawi yayitali, mpaka miyezi iwiri (McIlduff C.E. et al., 2011).

Ndemanga yomwe inafalitsidwa mu European Journal of Endocrinology (2012) imawunikira kuwunika kwa kafukufuku wamankhwala omwe amawunika zotsatira za ALA pa zotumphukira DN. Kutalika kwa chithandizo cha ALA kunali kuyambira masiku 14 mpaka 28. Mothandizidwa ndi mtsempha wa magazi wa ALA kwakanthawi kwamasabata 2-4 kumabweretsa chiwonjezeko chachikulu cha zotupa pamodzi ndi mafupa am'mitsempha yamagalimoto ndi minyewa yamagalimoto odwala omwe ali ndi zotumphukira DN. Chithandizo cha ALA sichimayenderana ndi chiwopsezo cha zochitika zovuta.

Pakadali pano, kugwiritsa ntchito bwino kwa ALA pochiza DN sikuwonetsedwa kokha mwa odwala akulu omwe ali ndi matenda ashuga, komanso mwa ana ndi achinyamata. Chifukwa chake, kuyang'anira kwa ALA pa mlingo wa 1800 mg patsiku pakapita masabata atatu kunapangitsa kusintha kwakukulu pakumverera (malinga ndi TSS, masikelo a NDS) ndikusintha magawo a electroneuromyographic, ndi

600 mg kwa miyezi iwiri idatsogolera kukhazikika kwa DN.

M'zaka zaposachedwa, njira za kupewa ndi kuchiza matenda ena a shuga ndi ALA afotokozedwa. Kusintha kwa maphunziro a microangiopathies ndi ALA akufotokozedwa. Mphamvu yoteteza antioxidant iyi mu matenda ashuga nephropathy imagwirizanitsidwa ndi kuthekera kwa mankhwalawa kusintha ntchito yamphamvu yamagetsi yodalira mphamvu ya membrane wa mitochondrial mu impso (Wang L. et al., 2013). Mwa odwala 32 omwe ali ndi matenda a shuga a 2 omwe ali ndi matenda ashuga retinopathy, kudalirika kogwiritsa ntchito nthawi yayitali kwa ALA (zaka 2) pa mlingo wa 600 mg patsiku pochiza retinopathy (malinga ndi ndondomeko ya fundus) kuwululidwa (Trakhtenberg Yu.A. et al., 2006). Pakufufuza kwa B.B. Heinisch et al. (2010) chithandizo ndi ALA pa mlingo wa 600 mg m'mitsempha itatu kwa masabata atatu bwino kusintha kwa endothelium-vasodilation wa 2 mtundu.

Kuphatikizika kwa kukonzekera kwa ALA mu chithandizo chovuta kwambiri cha matenda ashuga a m'mitsempha kumapereka mphamvu yotulutsa mphamvu komanso mphamvu yokwanira yogaya minyewa yam'mitsempha, potero kubwezeretsa kayendedwe kazovuta ka axonal mu minyewa yamitsempha ndikuchepetsa zovuta zamavuto amitsempha. Kukhazikitsidwa kwa ALA, kutengera nthawi yomwe mankhwalawo atha kulipira mtundu wa matenda ashuga amtundu wa 2, kumalola kuti munthu athe kupeza matenda osiyanasiyana a matenda ashuga polyneuropathy ndi zotulukapo zake mu mtundu wa SDS (Begma A.N., Begma I.V., 2009). Kukula kwa zochitika zambiri za SDS kumakhazikitsidwa ndi matenda ashuga polyneuropathy - mkhalidwe wamankhwala wodziwika ndi zizindikiro zina (kupweteka, paresthesia) kapena kuwonetsedwa ndi zizindikiro za kuwonongeka kwa mitsempha ya m'mitsempha (kutayika kwa miyendo).

Njira yothandizira odwala omwe ali ndi matenda ashuga okhala ndi polyneuropathy yokhala ndi kukonzekera kwa ALA imapangidwa bwino, ndipo pali zambiri pazachipatala zomwe zimagwiritsidwa ntchito.

Zambiri pazachipatala pakugwiritsa ntchito ALA zatsimikiziridwa ndi maphunziro angapo atagulitsa, omwe adachitika kwambiri ku Ukraine pakukonzekera kwa Espa-li-pon (Esparma GmbH, Germany). Espa-lipon, yemwe anali mmodzi wa oyamba kukonzekera ALA olembetsedwa ku Ukraine, adaphunzira zonse za endocrinological pathology ndi matenda a chiwindi, matenda osapatsirana a shuga a dongosolo la zotumphukira zamitsempha.

Chithandizo chimayamba ndi mtsempha wa magazi a ALA mu limodzi mlingo wa 600 mg kwa masiku 14-21. Popeza amatha kuyendetsa ALA kuchipatala kapena masiku ena (omwe sagwira ntchito), ALA nthawi zambiri imayendetsedwa kwa masiku 5 otsatiridwa, ndikutsatiridwa ndi kupumula kwa masiku awiri, ndipo masanjidwe otere amabwerezedwa katatu. Ndikotheka kumwa mapiritsi a ALA (kapena makapisozi) pamasiku omwe mankhwalawa sakupatsidwa. Gwiritsani ntchito zofupikitsa

maphunziro othandizira kulowetsedwa kwa ALA (mpaka 10 infusions) samalola muzochitika zambiri kuti akwaniritse kusintha kwamankhwala kwa odwala. Pamene infusions yokonzekera ALA, munthu sayenera kuyiwala za kufunika kwamdima wa botolo ndi yankho, chifukwa ALA imaphatikizidwa mosavuta ndi kuwala ndikuwonongeka. Kuti muchite izi, gwiritsani ntchito kukulunga mu botolo ndi yankho la ALA.

Kafukufuku wokhudzana ndi mphamvu ya ALA mu matenda ashuga polyneuropathy amachititsa kuganizira za kugwiritsa ntchito mapiritsi a ALA kumapeto kwa maphunzirowa kumapeto kwa miyezi iwiri. Mlingo woyenera wa ALA wowonjezera chithandizo cha matenda ashuga polyneuropathy pambuyo pakutha kwa kulowetsedwa ungaganizidwe kuti 600 mg.

Ubwino wofunikira wa ALA ndi kuchepa kochepa kwa zotsatira zoyipa. Chifukwa chake, mu maphunziro onse olamulidwa, zidadziwika kuti pafupipafupi zotsatira zoyipa pagulu la odwala omwe alandila ALA ndi placebo sizinasiyane pang'onopang'ono. Zotsatira zoyipa za ALA sizowopsa, ndipo pafupipafupi zimadalira mlingo. Pamene ALA idaperekedwa kudzera mu kafukufuku wa ALADIN, zotsatira zoyipa (kupweteka mutu, nseru, kusanza) nthawi zambiri zimawonetsedwa pa mlingo wa 1200 mg (32.6%) kuposa pa mlingo wa 600 mg (18.8%) ndi placebo (20.7%) . Kuphatikiza apo, ndi kulowetsedwa kwa oposa 50 mg / min, kuwonjezeka kwa kuthamanga kwa magazi, tachycardia ndi zovuta zopumira zimawonedwa. Pa Mlingo woyenera wochiritsira (kutengera mtundu wa mankhwalawa kapena kutulutsidwa kwa mankhwala ena), ALA ndi yotetezeka. Chiyeso chachipatala cha kugwiritsa ntchito ALA mwa amayi apakati sichinachitike.

Chifukwa cha kusowa kwa ALA m'madzi, yankho ndi 0,5-1% sodium mchere imagwiritsidwa ntchito pazoyang'anira. ALA imapanga zovuta kusungunuka ndi mamolekyulu a shuga, chifukwa chake sichigwirizana ndi yankho la glucose, yankho la Ringer, etc. Ndi makonzedwe omwewo a ALA ndi antidiabetesic agents (mankhwala amkamwa kapena insulin), mikhalidwe ya hypoglycemic imatha kuchitika chifukwa cha chidwi chachikulu cha insulin, chomwe chimafuna kuchepa kwa mlingo wa hypoglycemic agents. Mowa sukulimbikitsidwa panthawi yamankhwala ndi ALA. mchikakamizo chake, kuthandizira kwake kwamankhwala kumachepa. Thioctic acid imapanga zinthu zovuta ndi calcium, komanso zitsulo, kuphatikizapo magnesium ndi chitsulo. Kuvomereza kukonzekera komwe kuli ndi zinthu izi, komanso kugwiritsa ntchito zinthu zamkaka sizimaloledwa kale kuposa maola 6-8 mutatha ALA.

Zoletsa zina zamkati mwa ALA zokhala ndi zaka zopitilira 75, zotupa zatsopano mu fundus ndi kupezeka kwa kusinthasintha kwa mtima.

Malonjezo omveka bwino komanso odziwika bwino onena za kuthekera kwa kugwiritsa ntchito ALA mu matenda ashuga polyneuropathy anali mawu a Pulofesa N.P. Lyupke: "Alpha-lipoic acid ngati mankhwala

zochizira odwala omwe ali ndi matenda a shuga a polyneuropathy, lero ndiwothandizanso pochiza matenda ena, odutsa mayesero azachipatala, ali ndi kulolera bwino komanso chiopsezo chochepa. "

Njira yayikulu yolepheretsira DN mu shuga ndikukhazikitsa glycemia yokhazikika (chandamale), yomwe imalepheretsa kutseguka kwa njira zopsinjika za oxidative. Kukwaniritsa chiphuphu chokhazikika cha matenda komanso kugwiritsa ntchito mankhwala othandizira pathogenetic omwe ali ndi zotsimikizika zochizira (ALA) ndizofunikira komanso njira zofunikira zowongolera kupsinjika kwa oxidative kwa odwala omwe ali ndi matenda ashuga komanso kuwonongeka kwa dongosolo lamanjenje.

Tiyenera kukumbukira kuti kugwiritsa ntchito mlingo wa 600 mg ALA kumawerengedwa kuti ndiwokhazikika. Nthawi yomweyo, munthawi zina, kufunika kogwiritsa ntchito Mlingo wapamwamba wa ALA kunatsimikiziridwa, makamaka pakubwera kwa matenda a shuga. Kuchita bwino kwa mankhwalawa pakugwiritsa ntchito Mlingo wapamwamba wa ALA (900-1200 mg / tsiku) pochizira odwala omwe ali ndi matenda ashuga, kuphatikizapo kukhalapo kwa vuto linalake la zilonda zam'mimba, adawunika pofufuza mosawerengeka mwa odwala 116 okhala ndi mtundu woyamba wa 2 ndi matenda a shuga. Odwala adatenga ALA (Espa-lipon) mu / mu dontho la 600, 900 kapena 1200 mg / tsiku kwa masiku 10, kenako 600 mg pakamwa kwa miyezi iwiri. Kuchita bwino kwa mankhwalawa kunayesedwa ndi mphamvu ya ululu wamankhwala, kusintha kwa kugwedeza kwamphamvu musanalandire chithandizo komanso mutamaliza. Zotsatira zamankhwala zotchuka kwambiri, zomwe zinali zosiyana kwambiri ndi zoyambira, zimawonedwa m'gulu la odwala omwe akulandira ALA pa mlingo wa 1200 mg / tsiku. Pankhani ya vuto la necrotic necrotic, mphamvuzo zimayesedwa ndikuwonekera kwa kufalikira kwa cellulite, edema, komanso ndi kuchuluka kwa machiritso. Nthawi yowerengeka yofunika kwambiri pochiritsa zilonda inachepetsedwa m'gululi kulandira 1200 mg ya ALA patsiku (Larin A.S. et al., 2002-2003).

Zotsatira zakugwiritsa ntchito Mlingo wapamwamba wa ALA wa 1200 mg / tsiku pochiza matenda ashuga am'mimba zimapangitsa kuchepetsa kwambiri kutalika kwa odwala kuchipatala ndikuchepetsa kuchuluka kwa odwala omwe ali ndi vuto.

ALA pochiza matenda ena

Posachedwa, kufunikira kwathandizidwa pakugwiritsa ntchito antioxidants (ALA) popewa komanso kuchiza matenda omwe amaperekedwa ndikutulutsa kupsinjika kwa oxidative, kuphatikizapo erectile dysfunction (Kalinchenko S.Yu., Vorslov L.O., 2012).

Kuphatikiza apo, muzochitika zamankhwala, madokotala amakhudzidwa kwambiri pozindikira ndikuchiza DN yokhayokha, pomwe kuchuluka kwa dyshormonal (kogwirizana ndi zaka) ndi mowa wa neuropathy sikotsika (Salinthone S. et al.,

2008). Mosasamala kanthu za pathogenesis ya neuropathy, mawonekedwe a pathophysiological ake a chitukuko ndi chimodzimodzi ndipo amachepetsedwa ndikuphwanya mphamvu kagayidwe ndi activation ya oxidative nkhawa m'maselo a minyewa yamanjenje.

Chifukwa chake, zotsatira zina zofunika kwambiri za kukonzekera pafupipafupi kwa kukonzekera kwa ALA ziyenera kudziwika, monga, kukula kwa chiwindi ntchito (gawo la transamaz) ndi kapangidwe kake ka mbiri. Malinga ndi kafukufuku wazachipatala zingapo, kugwiritsa ntchito ALA kumathandizira kuti ntchito ya transaminase ndi cholestasis chikhazikitso (bilirubin, alkaline phosphatase, gammaglutamyl transpeptidase), ichititse kuchepa kwa microsis, imachepetsa kuopsa kwa zizindikiro za dyspepsia ndi ma akupanga zizindikiro za kuwonongeka kwa chiwindi kwa odwala omwe ali ndi chiwindi C. (Esaulenko E.V. et al. 2005, Shushlyapin O.I. et al., 2003).

Chifukwa chake, kafukufuku wokhudzana ndi kugwiritsa ntchito ALA (Espa-lipon 600 mg iv kwa masiku 10, ndiye pakamwa pakadutsa miyezi 6) mwa odwala omwe ali ndi matenda a hepatitis B ndi C adawonetsa kuchepa kwakukulu kwa zochitika za ma cytolysis, kupumula msanga kwa dyspeptic ndi asthenic syndromes poyerekeza ndi gulu lolamulira, makulidwe a transaminase ndi kuchepa kwa zizindikiro za ultrasound za kuwonongeka kwa chiwindi (Sizov D.N. et al., 2003).

Sizowopsa kuti chithandizo cha ALA chimaphatikizidwa muyezo wochizira matenda a chiwindi a hepatitis osiyanasiyana a etiology, cirrhosis, steatohepatosis osamwa mowa.

Zotsatira zabwino za ALA pa ntchito ya chiwindi zimatsimikizidwanso pakuphunzira kwa odwala omwe ali ndi matenda a shuga 1. Chifukwa chake, kutenga ALA (Espa-lipon 600 mg iv, masiku 20) okhala ndi chiwindi chamafuta m'magulu a odwala amaloledwa kuti asangotukula zochitika zonse za odwala, kuthetsa ululu ndi ma syndromes a dyspeptic, komanso kukwaniritsa kukonzanso kwathunthu kwa mafuta a metabolism , sinthanso cholesterol ndi milingo ya LDL, kuonjezera ntchito ya ma antioxidant michere - catalase, ceruloplasmin (Hvorostinka V.N. et al., 2003).Chifukwa chake, kuphatikiza kwa ALA mu chithandizo kumachulukitsa mphamvu ya mankhwalawa a matenda amtundu 1 shuga ndi mafuta a chiwindi.

Pakhalanso maphunziro angapo a ALA a hypothyroidism mwa odwala amisinkhu yosiyanasiyana.

Chifukwa chake, kuwunika kwa odwala akuluakulu omwe ali ndi autoimmune chithokomiro ndi hypothyroidism adawonetsa zotsatira zabwino za ALA (Espa-lipon 600 mg / tsiku pakamwa kwa miyezi 4) pamaphunziro a hypothyroidism, kuchepa kwa kuchuluka kwa mankhwala a thyroxine, komanso kusintha kwa matenda a neva. Kuphatikiza apo, mwa odwala omwe ali ndi dysmetabolic encephalopathy, ALA imathandizira kwambiri ubongo wa psychomotor (D. Kirienko et al., 2002).

Kugwiritsa ntchito ALA (Espa-lipon 600 mg pakamwa kwa miyezi itatu) mwa ana omwe ali ndi vuto lobadwa nawo

chithokomiro chinawonetsa kusintha kwakukulu kwa lipid metabolism (cholesterol, LDL, TG) komanso kuthamanga kwa kusintha kwakusintha kwa kusintha kwa ma atherogenic (Bolshova E.V. et al., 2011). Kugwiritsa ntchito ALA (Espa-lipon 600 mg iv kwa masiku 10, ndiye kuti 600 mg pakamwa, masiku 30) mwa odwala akuluakulu omwe ali ndi hypothyroidism adatsimikizira kusintha kwakukulu kwa metabolid ya lipid mothandizidwa ndi ALA. Kuphatikiza apo, atamaliza kulandira chithandizo, kusintha pamlingo wambiri kunatsimikiziridwa ndi odwala ambiri - 95% (Pankiv V.I. et al., 2003).

E.I. Chukanova et al. Kafukufuku wambiri wachitika kuti athe kuwunika momwe thioctic acid amathandizira odwala omwe ali ndi discirculatory encephalopathy (DE) komanso poika kuwonongeka kwa minyewa yovuta kuthandizira pathogenetic. Pa chitsanzo cha kafukufuku wa odwala 49 omwe ali ndi DE, zidawonetsedwa kuti kugwiritsa ntchito thiactic acid muyezo wa 600 mg 2 kawiri pa tsiku kwa masiku asanu ndi awiri ndi kusintha kwa 600 mg kamodzi patsiku kwa masiku 53 mkamwa mphindi 30 chakudya chisanalole kukwaniritsa zabwino pofika tsiku lachisanu ndi chiwiri la mankhwala (pa mlingo wa 1200 mg / tsiku), ndi kuchepetsedwa kwa mlingo mpaka 600 mg / tsiku (kuyambira tsiku lachisanu ndi chitatu la chithandizo), zotsatira zabwino za mankhwalawa pazomwe zimachitika mu minyewa ya minyewa zimakhalabe ndipo zimatchulidwa kwambiri ndi tsiku la 60. Mphamvu zabwino mu mitsempha ndi ma neuropsychological kuchuluka kwa odwala omwe ali ndi DE adadziwika. Malinga ndi zotsatira za kafukufukuyu, zidadziwika kuti thioctic acid imagwira ntchito pokhapokha pokhapokha odwala omwe ali ndi kuchuluka kwa glucose, komanso kwa odwala omwe ali ndi vuto la ubongo lopanda matenda a shuga. Pakufufuza kwa gulu la odwala 128 omwe ali ndi DE, kuwunika kwa mankhwala opatsirana pogwiritsa ntchito mankhwala opatsa thanzi odwala omwe ali ndi magawo osiyanasiyana a matenda amitsempha yamagazi osakwanira kunachitika. Kukonzekera kwa thioctic acid anali kutumikiridwa pakamwa tsiku lililonse la 600 mg 2 kawiri pa tsiku kwa masiku asanu ndi awiri ndi kusintha kwa 600 mg kamodzi patsiku kwa masiku 23 mphindi 30 asanadye. Olemba kafukufukuyo adatsimikiza kuti kulandira chithandizo ndi thioctic acid mwa odwala omwe ali ndi DE kumapangitsa kuti pakhale kusintha kwamankhwala ambiri, kumachepetsa chiopsezo chamikwingwirima panthawi yamatendawa komanso kumachepetsa kuchuluka kwa kupititsa patsogolo kwa odwala omwe ali ndi luso la DE I ndi II. Thioctic acid therapy ndiyabwino kuchokera pamalingaliro azachuma poyerekeza ndi mtengo wothandizira odwala omwe akuwongolera omwe adalandira antihypertensive ndi antithrombotic therapy, omwe amalumikizidwa ndi kuthana kwake kwakukulu pachiwopsezo chazovuta chosakhalitsa cha ischemic, stroko ndi kupitilira kwa DE.

Kugwiritsa ntchito kwa ALA kumathandizira kuchepetsa kwakukulu pazizindikiro zamatenda zomwe zimagwirizanitsidwa ndi DN, zimathandizira mkhalidwe wamapangidwe amanjenje, ndikupanga mwayi wokweza moyo wa wodwalayo kukhala wokwera kwambiri.

Kuchita bwino pa zamankhwala makamaka kumatengera zida zamakono zamakono komanso luso lalikulu lazachipatala. Kuphatikiza apo, zomwe takumana nazo zikuwonetsa kuti kupambana kwa nthawi yayitali mumankhwala kumadaliranso momwe zosowa za wodwala zimatengedwera.

Mwachidule, dziwani kuti njira yayikulu yolepheretsera DN mu shuga ndikukhazikika kwa standardoglycemia, yomwe imalepheretsa kutseguka kwa oxidative nkhawa njira. Kukwaniritsa chiphuphu chokhazikika cha matenda komanso kugwiritsa ntchito ma pathogenetic othandizira (ALA) omwe ali ndi zitsimikiziro zochizira ndizofunikira komanso njira zofunikira zowongolera kupsinjika kwa oxidative kwa odwala omwe ali ndi matenda ashuga komanso kuwonongeka kwa dongosolo lamanjenje. Alfa-lipoic (thioctic) acid ndi wamphamvu wa lipophilic antioxidant ndipo amawerengedwa ngati muyezo wagolide mu chithandizo cha matenda a shuga a matenda ashuga.

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6. Heinisch BV, Francesconi M., Mittermayer E. et al. Alpha-lipoic acid imasintha ntchito ya mtima wamatenda mwa odwala matenda ashuga a 2: kuyesedwa kwa placebo komwe kumayendetsedwa mwachisawawa // Eur. J. Clin. Wonongerani ndalama. - 2010 .-- Vol. 40, Ayi. 2. - P. 148-154.

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Kodi amamwa mankhwala awa?

Pofuna kupewa komanso kuchiza matenda a shuga 1 kapena mtundu wa 2, alpha-lipoic acid nthawi zina amapatsidwa mapiritsi kapena makapisozi mu mulingo wa 100-200 mg katatu patsiku. Mlingo wa 600 mg ndiwofala kwambiri, ndipo mankhwalawa amayenera kumwa kamodzi kokha patsiku, zomwe ndizosavuta kwambiri. Ngati mungasankhe zowonjezera zamakono za R-lipoic acid, ndiye kuti akuyenera kutengedwa mu yaying'ono - 100 mg 1-2 kawiri pa tsiku. Izi zikugwira ntchito makamaka kukonzekera komwe kumakhala ndi GioNova's Bio-Enhanced® R-Lipoic Acid. Werengani zambiri za iwo pansipa.

Kudya akuti adayamba kuchepa kwa bioavailability wa alpha lipoic acid. Chifukwa chake, izi zimapangidwira bwino pamimba yopanda kanthu, ola limodzi musanadye kapena maola awiri mutadya.

Ngati mungagwiritse ntchito matenda a shuga omwe mumafuna kulandira diquicctic acid, ndiye kuti dokotala akupatsirani mankhwalawo. Popewa kwambiri, alpha-lipoic acid nthawi zambiri amatengedwa ngati gawo la zovuta za multivitamin, pa mlingo wa 20-50 mg patsiku. Mpaka pano, palibe umboni wovomerezeka kuti kumwa antioxidant mwanjira imeneyi kumapereka phindu lililonse paumoyo.

Chifukwa chiyani ma antioxidants amafunikira

Amakhulupirira kuti kudwala ndi ukalamba zimayambitsa pang'ono mwa kusintha kwa zinthu kwaulere komwe kumachitika chifukwa cha zinthu zopanga makina a oxidation ("oyaka") mthupi. Chifukwa chakuti alpha-lipoic acid imasungunuka m'madzi ndi mafuta, imagwira ntchito ngati antioxidant pamagawo osiyanasiyana a metabolism ndipo itha kuteteza maselo ku zowonongeka ndi ma radicals aulere. Mosiyana ndi ma antioxidants ena, omwe amasungunuka m'madzi kapena mafuta okha, alpha lipoic acid imagwira ntchito m'madzi ndi mafuta onse. Ichi ndi chuma chake chapadera. Poyerekeza, vitamini E amangogwira m'mafuta, ndipo vitamini C amangokhala m'madzi. Thioctic acid imakhala ndi chiwonetsero chazonse chazithunzi zoteteza.

Ma antioxidants amawoneka ngati oyendetsa ndege a Kamikaze. Amadzipereka kuti athetse mitundu yaulere. Chimodzi mwazinthu zosangalatsa kwambiri za alpha lipoic acid ndikuti zimathandizira kubwezeretsa ma antioxidants ena atagwiritsidwa ntchito pazolinga zawo. Kuphatikiza apo, imatha kugwira ntchito ya ma antioxidants ena ngati thupi ndilosakwanira.

Alpha Lipoic Acid - Anti Peroxidant Wabwino kwambiri

Ma antioxidant othandizira achire ayenera kukwaniritsa njira zingapo. Izi ndi monga:

1. Zogulitsa ku chakudya.
2. Kusintha kwa maselo ndi minofu kukhala mawonekedwe ogwirika.
3. Ntchito zosiyanasiyana zoteteza, kuphatikizapo kuyanjana ndi ma antioxidants ena mu cell membranes ndi malo a interellular.
4. Kuopsa kochepa.

Alpha lipoic acid ndiwosiyana ndi ma antioxidants achilengedwe chifukwa amakwaniritsa zonsezi.Izi zimapangitsa kuti ikhale yothandiza kwambiri pochiritsa matenda omwe amayamba, mwa ena, kuwonongeka kwa oxidative.

Thioctic acid imakhala ndi ntchito zotsatirazi:

• Mwachindunji amathandizira mitundu yoopsa yogwiritsa ntchito mpweya wautali (ma free radicals).
• Imabwezeretsa antioxidants amkati, monga glutathione, mavitamini E ndi C, kuti agwiritsenso ntchito.
• Amamangirira (chelates) zitsulo zowopsa mthupi, zomwe zimapangitsa kuti kuchepa kwa kupanga ma free radicals.

Katunduyu amagwira ntchito yofunika kwambiri pakusamalira mgwirizano wama antioxidants - machitidwe omwe amatchedwa antioxidant defense network. Thioctic acid imabwezeretsa mwachindunji vitamini C, glutathione ndi coenzyme Q10, ndikuwapatsa mwayi wotenga nawo mbali mu metabolism ya thupi motalika. Imabweretsanso mosavomerezeka vitamini E. Kuphatikiza apo, akuti imawonjezera kaphatikizidwe ka glutathione m'thupi mwa nyama zokalamba. Izi zili choncho chifukwa kuchuluka kwa ma cell a cysteine, amino acid yofunikira pakapangidwe ka glutathione, kumawonjezeka. Komabe, sizinadziwikebe ngati alpha lipoic acid imathandizadi pakuwongolera njira ya redox m'maselo.

Ntchito mu thupi la munthu

Mthupi laumunthu, alpha-lipoic acid (kwenikweni, mawonekedwe ake a R okha, amawerengedwa kwambiri pansipa) amapangidwa m'chiwindi ndi minofu ina, komanso zakudya zam'chinyama ndi chomera. R-lipoic acid muzakudya imapezeka mu mawonekedwe omwe amalumikizidwa ndi amino acid lysine m'mapuloteni. Zozama kwambiri za antioxidant izi zimapezeka m'matupi aminyama, omwe ali ndi zochita zapamwamba kwambiri. Uwu ndi mtima, chiwindi ndi impso. Zomera zazikuluzikulu ndi sipinachi, broccoli, phwetekere, nandolo zam'munda, mphukira za Brussels, ndi chinangwa cha mpunga.

Mosiyana ndi R-lipoic acid, yemwe amapezeka muzakudya, mankhwala alpha-lipoic acid omwe amapezeka m'mankhwala amapezeka mwaulere, i.e. samamangidwa kumapuloteni. Kuphatikiza apo, Mlingo womwe umapezeka m'mapiritsi ndi jakisoni wa intravenous (200-600 mg) ndiwokwera kwambiri kuchulukirapo kawiri kuposa womwe anthu amapeza kuzakudya zawo. Ku Germany, thioctic acid ndi njira yovomerezeka yovomerezeka ndi matenda ashuga, ndipo akupezeka ngati mankhwala. Ku United States ndi mayiko olankhula Chirasha, mutha kugula ku malo ogulitsira mankhwala monga adokotala adauzira kapena monga zakudya zowonjezera.

Zachizolowezi Alpha Lipoic Acid motsutsana ndi R-ALA

Alfa-lipoic acid amapezeka m'mitundu iwiri ya maselo - lamanja (R) ndi lamanzere (limatchedwa L, nthawi zina limalembedwanso S). Kuyambira 1980s, mankhwala osokoneza bongo komanso zakudya zopatsa thanzi akhala osakaniza a mitundu iwiriyi muyezo wa 50/50. Kenako asayansi adazindikira kuti ndiokhoza (R) komwe ndi kachitidwe kogwira ntchito. Mu thupi laumunthu ndi nyama zina mu vivo mawonekedwe awa ndi omwe amapangidwa ndikugwiritsidwa ntchito. Amasankhidwa kuti R-lipoic acid, mu Chingerezi R-ALA.

Pali Mbale zambiri za alpha lipoic acid, zomwe ndi zosakaniza ndi "kumanja" ndi "kumanzere," chilichonse. Koma pang'onopang'ono imatsitsidwa pamsika ndi zowonjezera zomwe zimakhala ndi "yoyenera" yokha. Dr. Bernstein iyemwini amatenga R-ALA ndikungopereka odwala ake kwa odwala ake. Ndemanga za makasitomala ogulitsira achingelezi opezeka pachingerezi zimatsimikizira kuti R-lipoic acid ndiwothandiza kwambiri. Kutsatira Dr. Bernstein, tikulimbikitsa kusankha R-ALA m'malo mwa alpha lipoic acid.

R-lipoic acid (R-ALA) ndi mtundu wina wa molekyu ya alpha-lipoic acid yomwe zomera ndi nyama zimapangira ndikugwiritsa ntchito pansi pazachilengedwe. L-lipoic acid - yokumba, yopanga. Zowonjezera za alpha-lipoic acid ndizosakanikirana ndi mitundu ya L- ndi R-R, mu chiyerekezo cha 50/50. Zowonjezera zatsopano zimakhala ndi R-lipoic acid, R-ALA kapena R-LA zokha zolembedwa.

Tsoka ilo, kufananizira kwachindunji kwakukhudzana kwa mitundu yosakanikirana ndi R-ALA sikunapangidwepo komanso kusindikizidwa. Mutatenga mapiritsi "osakanikirana", kuchuluka kwa plasma ya R-lipoic acid ndiwokwera 40-50% kuposa mawonekedwe a L-form. Izi zikusonyeza kuti R-lipoic acid imatenga bwino kuposa L. Komabe, mitundu yonse iwiri ya thioctic acid imakonzedwa mwachangu kwambiri ndikuchotsa m'thupi. Pafupifupi maphunziro onse osindikizidwa okhudzana ndi alpha lipoic acid m'thupi la munthu adachitika mpaka 2008 ndipo zowonjezera zokha ndizomwe zidagwiritsidwa ntchito.

Ndemanga za makasitomala, kuphatikizapo odwala matenda ashuga, amatsimikizira kuti R-lipoic acid (R-ALA) ndiwothandiza kwambiri kuposa mankhwala osakanikirana a alpha-lipoic acid. Koma mwalamulo izi sizinatsimikizidwebe. R-lipoic acid ndi mawonekedwe achilengedwe - ndi thupi lake lomwe limatulutsa ndikugwiritsa ntchito. R-lipoic acid ndi wamphamvu kwambiri kuposa thioctic acid wamba, chifukwa thupi "limazindikira" ndipo limadziwa nthawi yomweyo kugwiritsa ntchito. Opanga amati thupi la munthu silingatengere mtundu wa L-mtundu, ndipo lingatilepheretse kugwira ntchito mwachilengedwe kwa R-lipoic acid.

Posachedwa, kampani ya GeroNova, yomwe imapanga "kukhazikika" R-lipoic acid, yatsogolera dziko lolankhula Chingerezi. Amatchedwa Bio-Enhanced® R-Lipoic Ac> BioEnhanced® Na-RALA. Anadutsa njira yokhazikika, yomwe GeroNova idachita. Chifukwa cha izi, digestibility ya Bio-Enhanced® R-lipoic acid yachulukanso ka 40.

Pakukhazikika, zitsulo zapoizoni ndi zotsekemera zotsalira zimachotsedweratu ndi chakudya. GeroNova's Bio-Enhanced® R-Lipoic Acid ndiye alpha lipoic acid wapamwamba kwambiri. Amaganiziridwa kuti kutenga izi m'mapilogalamu osavomerezeka kulibe vuto kuposa kulowetsedwa kwa thioctic acid ndi ma dontho.

GeroNova amapanga yaiwisi ya alpha lipoic acid. Koma makampani ena: Best a Doctor, Life Extension, Jarrow Formulas ndi ena akunyamula ndikuigulitsa kwa ogula omaliza. Pa tsamba la GeroNova kwalembedwa kuti anthu ambiri patatha milungu iwiri atazindikira kuti ali ndi mphamvu zambiri komanso akuganiza bwino. Komabe, tikulimbikitsidwa kuti mutenge R-lipoic acid kwa miyezi iwiri, kenako ndikumaliza.

Monga lamulo, anthu amatha kuphatikiza zokwanira za alpha lipoic acid kuti akwaniritse zosowa za thupi lawo. Komabe, kapangidwe kazinthu kameneka kamachepa ndi zaka, komanso mwa anthu omwe ali ndi mavuto azaumoyo, kuphatikizapo matenda a shuga komanso zovuta zake, monga neuropathy. Muzochitika izi, thioctic acid yowonjezereka, ikhoza kukhala yofunikira kupeza kuchokera kumagulu akunja - kuchokera pazowonjezera za chakudya m'mabotolo kapena jakisoni a intravenous.

Lipoic acid ndi wofunikira mu shuga

Anthu ambiri omwe ali ndi matenda amtundu wa 1 ndi mtundu wa 2 amakhala ndi vuto la matenda ashuga m'miyoyo yawo yonse. Malinga ndi ziwerengero, pafupifupi theka la onse odwala matenda ashuga azikhala ndi vuto la mitsempha. Matenda a shuga a shuga ndi mitsempha imawonongeka chifukwa cha kuchuluka kwa shuga m'magazi.

Matenda a shuga angayambitse mitsempha iliyonse m'thupi. Mitsempha yomwe imakhudzidwa kwambiri imakhala pakufika kwa thupi (mikono, zala, zala, ndi zala). Komabe, matenda ashuga a m'mimba amathandizanso misempha yam'mimba (matumbo, impso, ndi chiwindi).

Zizindikiro za matenda a shuga a shuga zimatengera mitsempha yomwe imakhudzidwa ndi matenda a shuga. Mwachitsanzo, misempha m'miyendo ikawonongeka, dzanzi ndi miyendo ndi m'miyendo zimatuluka. Kuwonongeka kwa mitsempha m'matumbo kumatha kuyambitsa nseru, kudzimbidwa, kutsegula m'mimba, kapena kumva kuti mwakhuta chakudya chochepa.

Kuzindikira kwa matenda ashuga a m'mimba

Kuzindikira kwa matenda ashuga a m'mimba nthawi zambiri kumachitika ngati pali zizindikiro za kuwonongeka kwa mitsempha mwa anthu omwe ali ndi matenda ashuga. Zizindikiro zake zingaphatikizeponso:

dzanzi, kumva kulira, kuwawa, kuwawa, kupweteka m'mimba, kutentha kwa mtima, kumva kuti mwatha kudya chakudya chochepa, kusintha kwa kuthamanga kwa magazi, chizungulire, kusowa kwa magazi kwa erectile.

Kuzindikira kumeneku kumatha kutengera mayesedwe monga kuyesa kwa Reflex, kuyezetsa magazi msempha, kapena ma elekitirogiramu.

Chofunikira kwambiri pochiza matenda a shuga a m'mimba ndicho kusungitsa shuga m'magazi anu mokhazikika komanso athanzi. Izi zimathandiza kupewa kuwonongeka kwina kwa mitsempha. Chifukwa chake, zizolowezi zoyenera kudya ndizofunikira kwambiri. Komabe, nchiani chomwe chingachitike ngati mitsempha yawonongeka? Kodi pali njira yobwezeretsanso misempha?

Tsoka ilo, njira yachikhalidwe yachikhalidwe imatsata kuti muzitha kugwiritsa ntchito bwino mankhwalawa. Ndipo muyenera kuyang'anitsitsa chithandizo chomwe chingabwezeretsenso mitsempha yowonongeka! Mankhwala monga antidepressants ndi NSAIDs nthawi zambiri amathandizidwa pochiza ululu womwe umayambitsidwa ndi matenda a shuga. Kwa zizindikiro zina, mankhwala ena amaperekedwa. Mwachitsanzo, Viagra ndi mankhwala othandizira kukanika kwa erectile.

Kuwongolera Matenda a shuga: Zambiri

Alpha-lipoic acid imakhala ndi phindu m'malo ambiri opweteka - matenda ashuga, kufooka kwamtundu wambiri, kuchepa kwa kuzindikira komanso kuchepa kwa chidwi. Popeza tili ndi tsamba pofotokoza za matenda ashuga, pansipa tikambirana momwe asidi wa thioctic alili mu mtundu woyamba wa 2 ndi mtundu wa 2 wa matenda a shuga pofuna kupewa komanso kuchiza matenda. Nthawi yomweyo, antioxidant iyi imatha kuchiza zovuta zambiri zaumoyo zomwe zimayambitsa matenda ashuga. Kumbukirani kuti ndi matenda amtundu wa 1 shuga, insulin secretion imachepetsedwa kwambiri chifukwa cha kuwonongeka kwa maselo a beta. Mtundu wachiwiri wa matenda ashuga, vuto lalikulu si kusowa kwa insulini, koma kufooka kwa minofu.

Zimatsimikiziridwa kuti zovuta za shuga zimachitika makamaka chifukwa cha kuwonongeka kwa minofu chifukwa cha kupsinjika kwa oxidative. Izi zitha kukhala chifukwa chowonjezeka pakupanga ma free radicals kapena kuchepa kwa chitetezo cha antioxidant. Pali umboni wamphamvu kuti kupsinjika kwa oxidative kumathandizira pakukula kwa zovuta za matenda ashuga. Shuga wokwera amatsogolera kukuwonjezeka kwa mitundu yamavuto yotopetsa ya okosijeni. Kupanikizika kwa Oxidative sikuti kumangoyambitsa zovuta za shuga, komanso kungagwirizanenso ndi insulin. Alpha lipoic acid imatha kukhala ndi prophylactic komanso achire pamavuto osiyanasiyana amtundu wa 2 komanso matenda a shuga.

Mu mbewa za labotale, matenda a shuga a mtundu woyamba 1 amachokera ku cyclophosphamide. Nthawi yomweyo, adaba jekeseni wa alpha-lipoic acid pa 10 mg pa 1 kg ya kulemera kwa thupi kwa masiku 10. Zinapezeka kuti kuchuluka kwa mbewa zomwe zimayambitsa matenda a shuga zatsika ndi 50%. Asayansi adawonanso kuti chida ichi chimawonjezera kugwiritsidwa ntchito kwa glucose mu minofu ya makoswe - diaphragm, mtima ndi minofu.

Mavuto ambiri omwe amayamba chifukwa cha matenda ashuga, kuphatikizapo ma neuropathy ndi matenda amkati, akuwoneka kuti ndi chifukwa chachulukidwe chopanga mitundu ya okosijeni yogwira mthupi. Kuphatikiza apo, zimaganiziridwa kuti kupsinjika kwa oxidative kumatha kukhala chochitika cham'mbuyo mu matenda a shuga, ndipo pambuyo pake kumakhudza zochitika komanso kuwonjezereka kwa zovuta. Kafukufuku wa odwala 107 omwe ali ndi matenda amtundu woyamba wa 2 ndi mtundu wa 2 adawonetsa kuti iwo omwe amamwa alpha-lipoic acid pa 600 mg patsiku kwa miyezi itatu adachepetsa kupsinjika kwa oxidative poyerekeza ndi omwe amadwala matenda ashuga omwe sanakhazikitsidwe antioxidant. Izi zimawonetsedwa ngakhale mphamvu ya shuga m'magazi ikanakhalabe yopanda pake komanso kuchuluka kwa mapuloteni mumkodzo kunali kwakukulu.

Alpha Lipoic Acid Against Diabetesic Neuropathy

Mwamwayi, pali chithandizo chomwe chingathandize kubwezeretsa mitsempha yowonongeka ndi matenda a shuga. Alpha lipoic acid ndi amino acid womwe umatha kugwiritsidwa ntchito kudzera m'mitsempha.

Kafukufuku wambiri wasonyeza kuti kupangika kwa alpha-lipoic acid kumachulukitsa mphamvu ya mitsempha yomwe imakhudzidwa ndi matenda a shuga.

Kafukufuku ambiri akuwonetsa kuti kuphatikizika kwa alpha-lipoic acid kumakhala ndi zotsatirapo zazifupi komanso zazifupi zakuwonongeka kwa mitsempha chifukwa cha matenda a shuga.

Ngati mukuvutika ndi zovuta za matenda ashuga a mtima, onetsetsani kuti mwakambirana ndi dotolo wanu za chithandizo cha lipoic acid.

Lipoic acid: njira yotsimikiziridwa ya matenda a shuga

Lipoic acid, alpha-lipoic acid, thioctyl acid - ziribe kanthu chomwe amachitcha, izi sizisintha mfundo kuti mpaka posachedwapa palibe amene adamva izi. Komabe, masiku ano, othandizira azaumoyo omwe amapita patsogolo amazindikira kuti ndi antioxidant wachilengedwe komanso chithandizo chachikulu cha matenda a shuga.

Mphamvu ya simba la lipoic acid ili m'mbali ziwiri zomwe zimagwira mthupi. Monga wosewera wabwino wamagulu omwe amatha kusewera komanso kudzitchinjiriza, lipoic acid imatha kuchita zonse ngati antioxidant komanso yoteteza madzi sungunuka ndi mafuta osungunuka a mafuta, kuphatikiza glutathione, vitamini C, vitamini E ndi coenzyme Q101.

Palibe michere ina iliyonse yomwe imatha kuchita izi. Kuphatikiza apo, lipoic acid imapangitsa thupi kusanduliza bwino mphamvu kukhala chakudya, limathandiza kupewa kufalikira kwa mafuta ndipo limathandizanso pochotsa zakumwa ndi zinthu zina zamafuta kagayidwe.

Kuteteza matenda a shuga

Ndikosavuta kupeza chinthu chomwe chili chofunikira kwambiri kwa odwala matenda ashuga, kaya ndi mtundu woyamba wa II kapena wa II, womwe ndi matenda osiyanasiyana. Kutengera ndi zotsatira zomwe zapezeka ku Europe, komwe lipoic acid wagwiritsidwa ntchito kwazaka pafupifupi makumi atatu, ndili ndi chitsimikizo kuti lidzakhala chithandizo chokhacho chothandiza kwambiri ku matenda a shuga.

Poganizira makamaka kuti palibe njira zina zochiritsira, ichi ndi chitsanzo chabwino kwambiri cha chinthu chachilengedwe chomwe chimayenerera - koma sichilandira - chifanizo cha njira yodziwikiratu, panthawiyi, yothandizira matenda osokoneza bongo okhudzana ndi shuga m'mikono ndi miyendo.

Pakafukufuku wina, Mlingo wa tsiku ndi tsiku wa 300 mpaka 600 mg wa lipoic acid unachepetsa ululu wamitsempha m'milungu khumi ndi iwiri, ngakhale kuti palibe kusintha kwenikweni kwa ntchito ya mitsempha1 Kupumula kwachidziwitso kwakutali kunapezeka mu kafukufuku wina, pomwe onse pakamwa ndi mkati mwa 600 mg3 anagwiritsidwa ntchito.

Poyesanso kwinanso, ofufuza adavomereza kuchuluka kwa kusintha kwa zizindikiritso pa 80% odwala 329 atavomera kulandira neuropathy atalandira chithandizo cha milungu itatu ndi mankhwala a lipoic acid.

Lipoic acid amatsutsa insulin kukana ndipo amamukulitsa kwambiri ma cell a glucose. Mwachitsanzo, kukonzekera kwa mtsempha wa 1000 mg wa lipoic acid kumathandizira kuti glucose atenge maselo ndi 50%. Zotsatira zoyesa nyama zikuwonetsa kuti lipoic acid imatetezanso maselo a pancreatic omwe amapanga insulin.

Kuwonongeka kwa maselo amtunduwu kumabweretsa mtundu wa matenda a shuga a shuga ndikuyamba kudalira jakisoni wa insulin. Powonjezera, mankhwala a lipoic acid ayenera kukhala othandiza pochiza matenda oyamba a matenda a shuga a I, pomwe si ma cell onse opanga insulin omwe anamwalira. Ndayamba kale kuzigwiritsa ntchito pazolinga izi, koma sindinakhalepo ndi chiwerengero chokwanira cha odwala chotere kuti athe kupeza zifukwa zomveka.

Kukumana ndi zofunikira

Aliyense amene wonenepa kwambiri kapena wakudya kwambiri wama carb ali pachiwopsezo cha matenda a shuga, chifukwa chake lipoic acid ndiyabwino kwa ambiri a ife. Mavuto ena wamba azaumoyo amathandizanso pakufunika kwa michereyi.

Lipoic acid imachepetsa mitundu yonse ya oxidation yaulere, ngakhale m'mitsempha kapena m'maso. Mu ubongo, amatha kuthandizira kuchepetsa kapena kupewa kuwonongeka kwa ma cell ku matenda a Alzheimer's. Kafukufuku wazinyama adawonetsa kale kuthekera kwake kukonza magwiridwe antchito ndikuzindikira.

Kuphatikiza apo, lipoic acid ndi chitetezo champhamvu cha chiwindi. Kafukufuku wina adawonetsa kuti mwa anthu omwe amamwa vinyo nthawi zonse, amateteza chiwindi ku zakumwa zoledzeretsa. Lipoic acid ndi gawo limodzi lofunika la chithandizo cha Edzi chifukwa limalepheretsa kubwereza kwa HIV. Ndikothekanso kuti zitha kukhala zothandiza ngati wothandizira chelating *, makamaka pochotsa mkuwa wowonjezereka m'thupi.

Malangizo owonjezera

Palibe mavuto azachipatala, mlingo wabwino wa tsiku la lipic uli pakati pa 100 ndi 300 mg. Tengani Vitamini B1 monga chowonjezera. Mu milandu yomwe antioxidant yathunthu imafunikira kuti athane ndi metabolic kukana kuchepa thupi, ndimapereka mankhwala kuchokera 300 mpaka 600 mg patsiku. Monga gawo la matenda anga a shuga, khansa, kapena Edzi, ndimagwiritsa ntchito 600- 900 mg.

Kupatula kupezeka kachilendo kwakakhungu, lipoic acid ilibe zotsatira zoyipa kapena kuyanjana ndi mankhwala. Zotsatira zokhazokha zamankhwala zimakhala kuti odwala matenda ashuga angafunikire kuchepetsa kufunika kwa insulini kapena mankhwala ena odana ndi matenda ashuga, omwe akuyenera kuchitika moyang'aniridwa ndi dokotala. Koma pamapeto pake izi ndi zomwe ziyenera kukhala chimodzi mwazolinga zazikulu.

Alpha lipoic acid pochiza ululu wa neuropathic odwala omwe ali ndi matenda osokoneza bongo

Neuropathy ndi zovuta zowonjezera za shuga mellitus, zomwe zimalumikizidwa ndi kulemala kwakukulu komanso kuchepa kwa moyo wa wodwalayo. Amadziwika kuti izi ndizotsatira za kuwonongeka kwa ziwiya zazing'ono komanso ma capillaries omwe amapereka mitsempha ya mitsempha. Cholinga chotsirizira ndikuwonjezereka kwa kupanga ma free radicals mu mitochondria chifukwa cha hyperglycemia.

Peripheral neuropathy imayamba ndi miyendo kenako imafalikira pang'ono mpaka kumiyendo yotsika. Kuphatikiza pa kuchepetsa kuchepa kwa chidwi, komwe kumakhala chiwopsezo cha zilonda zam'mapazi a neurotrophic, kupweteka kwa neuropathic kumatha kuchitika ngati chizindikiro cha polyneuropathy. Kupweteka kwamitsempha kumatha kuwonetsedwa ndikumverera kwa kugunda, kuwotcha komanso kulanda.

Pali chiwerengero chambiri chazomwe chikuwonetsa kuti kupezeka kwa zovuta zazovuta zam'magazi kumalumikizidwa ndi kupezeka kwa nthawi yayitali kwa kagayidwe ka shuga komanso kuuma kwake. Hyperglycemia induces imapanga kupanga ma free radicals a oxygen mu mitochondria (oxidative kapena oxidative nkhawa), yomwe imayambitsa kutsegulidwa kwa njira zinayi zodziwika za kuwonongeka kwa hyperglycemic: polyol, hexosamine, proteinasease C ndi AGE.

ALA idazindikirika mu 1951 ngati coenzyme mu tricarboxylic acid mzunguko (Krebs mzunguko). Zatsimikizira kuti ndi antioxidant wamphamvu yomwe akuti yachepetsa kuopsa kwa zotupa za micro- ndi macrovascular mu mitundu ya nyama.

Kafukufuku waposachedwa wokhudzana ndi odwala omwe ali ndi matenda amtundu wa 1 adawonetsa kusintha kwa mapangidwe a AGE ndi kulepheretsa kwa njira ya hexosamine (Du et al., 2008). ALA ngati njira yoletsera kuwonongeka kochokera ku hyperglycemia sikungakhale ndi zotsatira za analgesic, komanso kukonza ntchito ya mitsempha.Kuphatikiza apo, poyerekeza ndi mankhwala omwe amagwiritsidwa ntchito masiku ano, ALA ili ndi zovuta zochepa.

Zipangizo ndi njira zakufufuzira

Mu 2009, olemba kafukufukuyu adafufuza zolemba zogwirizana ndi zamasamba a MedLine, PubMed, ndi EMBASE. Kusaka kumeneku kunachitika pogwiritsa ntchito mawu akuti "lipoic acid", "thioctic acid", "shuga", "shuga mellitus". Njira yofananira yosaka idagwiritsidwa ntchito pakusaka ku EMBASE. Zotsatira zakusaka kwa PubMed zidasefedwa kuti zisankhe mayesero oyendetsedwa mwachisawawa (ma RCT) ndi kuwunikira mwadongosolo.

EMBASE adagwiritsa ntchito fayilo yotengera umboni, yomwe ikutanthauza kufufuzidwa kochokera. Ndemanga zadongosolo zinafufuzidwa mu Cochrane Library. Njira zophatikizira zotsatirazi zinagwiritsidwa ntchito pochita maphunziro: RCTs kapena kuwunika mwatsatanetsatane kwa kukhudzika kwa ALA, kuchuluka kwa kafukufukuyu kuyimiriridwa ndi odwala omwe ali ndi matenda osokoneza bongo komanso kupweteka kwa zotumphukira za neuropathic, kugwiritsidwa ntchito kwa chizindikiro chodziwika bwino (TSS) ngati chiyeso choyambirira.

Njira zowachotsera anali: maphunziro oyesera ndi zolemba zomwe sizinalembedwe Chingerezi. Olembawo adasankha zomwe zidafunikazo, kenako nkumachita msonkhano kuti akambirane zotsutsana ndikupeza mgwirizano. Lingaliro lomaliza la kuphatikiza kapena kupatula zolemba zina zowunikirazo lidapangidwa pambuyo popenda zolemba zathunthu.

Mabuku omwe adagwiritsidwa ntchito pazopangazi adaphunziranso ntchito yoyenera. Zambiri zosasindikizidwa ndi malipoti a msonkhano sizinaphatikizidwe muwunikenso. Olembawo adadziyimira pawokha pawokha pakuwunika kulikonse pogwiritsa ntchito njira zowunikira za RCT komanso kuwunika mwadongosolo komwe kunapangidwa ndi Dutch Cochrane Center. Umboni ndi malingaliro zidakhazikitsidwa potengera zomwe Oxford Center for Evidence-based Medicine (2001).

Zotsatira zakusaka ndi zokambirana

Pazofufuza, mabuku 215 adadziwika mu PubMed ndi 98 ku EMBASE. Nditayang'ananso mitu ndikuyambiranso, ma RCT khumi anasankhidwa momwe zotsatira za ALA mwa odwala omwe ali ndi matenda ashuga a m'mimba amaphunziridwa.

Ndemanga imodzi mwatsatanetsatane idadziwika mu PubMed ndi EMBASE ndipo idaphatikizidwa pakuwunikira. Palibe zowunikira mwadongosolo zopezeka mu Library ya Cochrane. Panalibe kusagwirizana pakati pa olemba ponena za zofalitsa zomwe zidasankhidwa kuti zikaphatikizidwe pakuwunika.

Mayeso olamulidwa popanda dzina

Kuchuluka kwa odwala omwe adaphunzira mu RCTs zisanu zosankhidwazo kunali ndi odwala omwe ali ndi zotumphukira za matenda a shuga (Ziegler et al., 1995, 1999, 2006, Ametov et al., 2003, Ruhnau et al., 1999). Zaka zimachokera zaka 18-74, ndipo odwala ambiri omwe ali ndi matenda a shuga a mtundu wachiwiri. Zotsatira za ALA zotengedwa pakamwa zimaphunziridwa m'maphunziro atatu, mkati mwa awiri, ndipo kuphatikiza (pakamwa + kudzera m'mitsempha) mu imodzi (Gome 1).

Chifukwa chake, kusintha kwa 30% pachizindikiritso pamlingowu kunawonedwa kukhala kofunika kwambiri (kapena points 2 mfundo wodwala wokhala ndi maziko a ≤ 4 point). Kusintha kwakukulu mu mfundo za TSS kunanenedwa m'maphunziro anayi mwa asanu: pafupifupi, kutsika kwa 50% kuzindikirika kuzindikirika kumawonedwa ndi pakamwa kapena mkati mwa osachepera 600 mg / tsiku la mankhwalawa.

Komabe, poyerekeza ndi odwala omwe ali pagulu lolamulira, kutsika kwa TSS score kunali kochepa poyerekeza ndi 30%, popeza kuchuluka pamlingo wamagulu olamulirawo kunachepetsedwa. Izi zinaonekera kwambiri m'maphunziro momwe ALA inkathandizira pakamwa. Muyeso limodzi momwe mankhwalawa adathandizira kudzera m'mitsempha, gulu lolowererapo linawonetsa kuchepa kwapamwamba kwa 30% mu TSS score poyerekeza ndi gulu lolamulira (Ametov et al., 2003).

Mlingo> 600 mg sizinachititse kuti chiwonetsero cha TSS chiwonjezeke kwambiri, koma zimayendetsedwa ndi zovuta zambiri monga kuphwanya mseru, kusanza komanso chizungulire.Zotsatira zoyipa zomwe zimawonedwa pogwiritsa ntchito Mlingo wa ≤ 600 mg / tsiku sizinasiyane ndi zomwe zimachitika ndi placebo.

Ubwino wama Methodist ama RCT

Ma RCT anayi anali abwino: awiri ophunzirira mankhwala a ALA a pakamwa, awiri - intravenous (mulingo wa umboni 1b) (Ziegler et al., 1995, 2006, Ametov et al., 2003, Ruhnau et al., 1999). RCT imodzi inali ndi malire aukadaulo (mulingo wa umboni 2b), popeza ambiri odwala adasiya phunziroli, ndipo chifukwa chake zotsatira zake zitha kupotozedwa (Ziegler et al., 1999) Zotsatira za kuyesa kwazomwe zikuwonetsedwa mu tebulo 3.

Ndemanga mwatsatanetsatane komanso kusanthula kwa meta

Kuwunikira kwa meta kwama RCT anayi kunapezeka, olemba omwe adatsimikiza kuti kudya kwa ALA kwa milungu itatu (600 mg / tsiku) kumakhudzanso kuchepetsa kupweteka kwa neuropathic (Ziegler et al., 2004). Palibe maphunziro omwe adaphatikizidwa kuti aphunzire mankhwala operekedwa pakamwa. Kuwunikira kwa meta sikunakwaniritse zofunikira za Cochrane Collaboration.

Chidziwitso chinasankhidwa popanda kugwiritsa ntchito MedLine, zofalitsa sizinasankhidwe ndi owonerera awiri pawokha, mtundu wazinthu zomwe zaphatikizidwazo sizinayesedwe. Zotsatira zamayesero azachipatala zomwe zidawunikidwa mwachidule zidafotokozedwa mwachidule popanda kupanga magulu ena amtundu uliwonse wa ALA omwe amagwiritsidwa ntchito pa kafukufuku aliyense.

Chifukwa chake, mtundu wa kusanthula kwa meta uku sikukwaniritsa zofunikira, chifukwa chake zotsatira sizinaphatikizidwe muwunikenso.

Kutengera mayesero anayi osasinthika, oyesedwa ndi placebo omwe akuphatikizidwa pakuwunikira, pali umboni kuti ALA imatsogolera pakuchepetsa kwakukulu kwa kupweteka kwamankhwala a neuropathic mukamagwiritsa ntchito kwa masabata atatu pa mlingo wa 600 mg / tsiku (kalasi yovomerezera A) .

Chifukwa chake, maphunziro a nthawi yayitali amafunikira kuti awunike zotsatira zakuchedwa za ALA. Kupitiliza kwa chithandizo chamankhwala aliwonse ndizofunikira kwambiri pazovuta monga matenda a shuga. Njira zotheka zomwe ALA imaletsa kupweteketsa kwa neuropathic odwala omwe ali pachiwopsezo chachikulu amafunikiranso kuphunzira.

Therapy ya alpha ya ALA imangobweretsa kusintha kwakukuru mu kupweteka kwa matenda ashuga a mtima. Tsoka ilo, pakadali pano, palibe deta yomwe ikupezeka pakugwiritsa ntchito kwa nthawi yayitali. Malinga ndi zotsatira zomwe zaperekedwa mu kuwunikaku, mankhwala othandizira a ALA pochizira matenda a shuga angayambitsidwe.

Zopindulitsa zomwe zimawonedwa ndi ALA yokhudza pakamwa zimafotokozedwa mwatsatanetsatane, kotero maphunziro ena amafunikira. Pakadali pano palibe malingaliro ogwiritsira ntchito pakamwa pa ALA pochiza matenda a shuga.

Alpha lipoic acid ndi matenda ashuga, kulumikizana bwanji?

Alfa-lipoic acid, omwe amadziwikanso kuti thioctic acid, lero ndi amodzi mwa antioxidants odziwika bwino, omwe asayansi amakono apereka ulemu wa antioxidant wapadziko lonse chifukwa cha mawonekedwe apadera a chinthuchi.

Muli ALA mu nyama, masamba, sipinachi, yisiti ndi chiwindi. Ngati ndi kotheka, thupi lathu limatha kudzipangira palokha ALA.

Kuti muchite ntchito za antioxidant, asidi ayenera kukhala m'maselo a thupi momasuka, mopitirira muyeso. Popeza kuti zomwe zili ndi alpha-lipoic acid m'thupi ndizochepa, ndikofunikira kupaka jekeseni kapena kutenga zowonjezera kuti mupeze zotsatira.

Kuchuluka kwa insulin

Kumangidwa kwa insulini ku ma receptor ake, omwe amakhala pamwamba pa ziwalo zam'mimba, kumayendetsa kayendedwe ka glucose onyamula (GLUT-4) kuchokera mkati mpaka membrane wa cell ndikuwonjezera kuyamwa kwa glucose kuchokera m'magazi ndi maselo. Alpha-lipoic acid idapezeka kuti yambitsa GLUT-4 ndikuwonjezera kutulutsa kwa shuga ndi adipose ndi minofu ya minofu.Zimapezeka kuti zimakhudzanso insulin, ngakhale nthawi zambiri imakhala yofooka. Minofu yachigoba ndiye gawo lalikulu la glucose scavenger. Thioctic acid kumawonjezera minofu minofu glucose. Ndiwothandiza kwambiri pakanthawi yayitali matenda a shuga.

Komabe, Kafukufuku wasonyeza kuti, mosiyana ndi kayendetsedwe ka intravenous, mutatha kumwa mapiritsiwo pakamwa, pali kusintha kochepa kwambiri pakumveka kwa minofu kuti mumve insulin (Momwe mungayitanitsire alpha lipoic acid kuchokera ku USA pa iHerb - tsitsani malangizo atsatanetsatane mu Mawu kapena mawonekedwe a PDF. Chilankhulo cha Russia.

Chifukwa chake, tidazindikira chifukwa chake zowonjezera za alpha-lipoic acid zaku America ndizothandiza komanso zosavuta kuposa mankhwala omwe mungagule ku pharmacy. Tsopano tiyeni tiyerekeze mitengo.

Kuchiza ndi mankhwala apamwamba kwambiri a ku America a alpha lipoic acid kumafuna ndalama $ 0,3- $ 0,6 patsiku, kutengera mlingo. Mwachiwonekere, izi ndizotsika mtengo kuposa kugula mapiritsi a thioctic acid ku pharmacy, ndipo ndi otsitsira mtengo kusiyana pamtengo nthawi zonse. Kuitanitsa zowonjezera kuchokera ku United States kudzera pa intaneti kungakhale kovuta kwambiri kuposa kupita ku pharmacy, makamaka kwa anthu achikulire. Koma zidzalipira, chifukwa mudzapeza zabwino zenizeni pamtengo wotsika.

Umboni wochokera kwa madokotala ndi odwala matenda ashuga

Gome ili pansipa lili ndi zolemba zamankhwala am'mbuyomu omwe ali ndi alpha lipoic acid. Zida pamutuwu zimapezeka pafupipafupi m'magazini azachipatala. Mutha kudziwana nawo mwatsatanetsatane, chifukwa zofalitsa zaluso nthawi zambiri zimatumiza zolemba zawo kwaulere pa intaneti.

Na. P / tsa	Mutu wa nkhaniyi	Magazini
1	Alpha-lipoic acid: multifactorial zotsatira ndi cholinga chogwiritsidwa ntchito mu shuga	Medical News, Na. 3/2011
2	Okulosera mphamvu ya matenda a matenda ashuga polyneuropathy a m'munsi malekezero ndi alpha lipoic acid	Therapeutic Archive, Na.10 / 2005
3	Ntchito ya oxidative nkhawa mu pathogenesis ya matenda ashuga neuropathy ndi kuthekera kwake kukonza ndi alpha-lipoic acid kukonzekera	Mavuto a Endocrinology, No. 3/2005
4	Kugwiritsira ntchito lipoic acid ndi vitagmal mwa amayi apakati omwe ali ndi mtundu I shuga mellitus popewa kupsinjika kwa oxidative	Zolemba za Obstetrics ndi Matenda a Akazi, No. 4/2010
5	Thioctic (alpha-lipoic) acid - mitundu yambiri ya ntchito zamankhwala	Journal of Neurology and Psychiatry otchedwa S. S. Korsakov, Na.10 / 11
6	Kukhalitsa kwa mphamvu pambuyo pa milungu itatu ya mtsempha wa magazi wa alpha-lipoic acid mu matenda ashuga a polyneuropathy	Therapeutic Archive, No. 12/2010
7	Mphamvu ya alpha-lipoic acid ndi mexidol pa neuro- komanso makonda a odwala omwe ali ndi magawo oyamba a matenda a shuga	Chithandizo cha Zachipatala, No. 10/2008
8	Zotsatira zamankhwala ndi morphological ndi kugwiritsa ntchito bwino kwa alpha-lipoic acid wodwala matenda am'mimba mwa ana ndi achinyamata omwe ali ndi matenda a shuga	Bulletin yaku Russia ya Perinatology and Pediatrics, No. 4/2009

Komabe, ndemanga za madokotala olankhula ku Russia zokhudzana ndi kukonzekera kwa alpha-lipoic acid ndi zitsanzo zomveka bwino zachikondi chabodza. Zolemba zonse zomwe zimafalitsidwa zimathandizidwa ndi omwe amapanga mankhwala amodzi kapena ena. Nthawi zambiri, Berilition, Thioctacid ndi Thiogamm amalengezedwa motere, koma opanga ena amayesetsanso kupititsa patsogolo mankhwala awo komanso zowonjezera.

Mwachiwonekere, madokotala ali ndi chidwi chachuma polemba eulogies okha pazokhudza mankhwala. Chidaliro mwa iwo kuchokera kwa odwala omwe ali ndi matenda ashuga sichiyeneranso kukhala ansembe achikondi, pamene atsimikizira kuti sakadwala ndi matenda opatsirana pogonana. M'mawunikidwe awo, madotolo amawonetseratu kuchuluka kwa mankhwala omwe amagulitsidwa ku malo ogulitsa mankhwala. Koma ngati muwerenga ndemanga za wodwalayo, mudzazindikira kuti chithunzicho sichabwino kwambiri.

Ndemanga ya omwe amalankhula ndi odwala matenda ashuga olankhula Chirasha za alpha lipoic acid, yomwe imapezeka pa intaneti, imatsimikizira izi:

1. Mapiritsi kwenikweni samathandiza.
2. Madontho okhala ndi thioctic acid amathandizadi kukhala ndi thanzi la matenda ashuga, koma osakhalitsa.
3. Malingaliro olakwika komanso zabodza zakutchire za kuopsa kwa mankhwalawa ndizofala pakati pa odwala.

Hypoglycemic coma imatha kupezeka pokhapokha ngati wodwala matenda ashuga amathandizidwa kale ndi mapiritsi a insulin kapena mapiritsi a sulfonylurea. Kuphatikizika kwa thioctic acid ndi othandizira amatha kutsika shuga wamagazi kwambiri, ngakhale mpaka kumatha kuzindikira. Ngati mwaphunzira nkhani yathu yokhudza mankhwala omwe ali ndi matenda ashuga a mtundu wa 2 ndikusiya mapiritsi owopsa, ndiye kuti palibe chodandaula.

Chonde dziwani kuti chida chachikulu chothandizira matenda a neuropathy ndi zovuta zina za matenda ashuga ndi chakudya chamagulu ochepa. Alpha lipoic acid amatha kungowonjezera, ndikupititsa patsogolo kubwezeretsa kwachilendo kwa zamanjenje. Koma bola zakudya za anthu odwala matenda ashuga azikhala ndi zochuluka zamagalimoto, sizingamveke bwino pakudya zina zowonjezera, ngakhale mu mawonekedwe a kulowetserera mtsempha.

Tsoka ilo, ndi odwala ochepa olankhula Chirasha omwe amadziwa bwino za zakudya zamagulu otsika pang'ono a mtundu 1 ndi matenda ashuga a 2. Uku ndikusintha kwenikweni kwamankhwala, koma kumadutsa pang'onopang'ono kuchuluka kwa odwala ndi madokotala. Anthu odwala matenda ashuga, omwe samadziwa za zakudya zamagetsi otsika pang'ono ndipo samatsatira, amataya mwayi wabwino wokhala ndi ukalamba popanda zovuta, ngati anthu athanzi. Kuphatikiza apo, madokotala akukana zosintha, chifukwa ngati odwala onse omwe ali ndi matenda a shuga a mtundu wa 2 azilandira pawokha, ndiye kuti endocrinologists adzatsalira osagwira ntchito.

Kuyambira 2008, zakudya zatsopano za alpha-lipoic acid zatulukira ku mayiko olankhula Chingerezi, zomwe zili ndi "patsogolo" - R-lipoic acid. Makapisozi awa amakhulupirira kuti amagwira ntchito kwambiri mu matenda ashuga a mtima, ofanana ndi mtsempha wamitsempha. Mutha kuwerenga ndemanga zokhudzana ndi mankhwala atsopano pamasamba achilendo ngati mukudziwa Chingerezi. Palibe ndemanga mu Russia pano, chifukwa tangoyamba kuuza odwala matenda ashuga okhudza mankhwalawa. Ma supplements a R-lipoic acid komanso mapiritsi olimbitsa a alpha-lipoic acid ndi malo abwino olowa m'malo otsitsa mtengo komanso osasangalatsa.

Tikugogomezeranso kuti kudya zakudya zamagulu ochepa ndizomwe zimathandiza kwambiri odwala matenda ashuga komanso mavuto ena, ndipo alpha lipoic acid ndi zina zowonjezera zimathandizanso. Timapereka zidziwitso zonse zamagulu ochepa a chakudya chamagulu 1 ndi mtundu wa 2 waulere.

Alpha lipoic acid imatha kukhala yothandiza kwambiri popewa komanso kuchiza matenda ashuga. Imakhala ndi zochizira munthawi zingapo munjira zingapo:

1. Imateteza khungu la ma pancreatic beta, limalepheretsa kuwonongeka kwawo, ndiye kuti, limachotsa zomwe zimayambitsa matenda a shuga 1.
2. Zimalimbikitsa kukoka minofu glucose mu mtundu 2 shuga, kumawonjezera insulin.
3. Imagwira ngati antioxidant, yomwe ndiyofunikira kwambiri kuti muchepetse kukula kwa matenda ashuga, komanso komanso osasintha mavitamini C.

Kukhazikitsidwa kwa alpha-lipoic acid ogwiritsa ntchito mafupa amkati kumawonjezera chidwi cha insulini kwa odwala omwe ali ndi matenda a shuga a 2. Nthawi yomweyo, maphunziro azachipatala omwe adachitika 2007 zisanachitike akuwonetsa kuti kumwa mapiritsi a antioxidant kulibe kanthu. Izi zili choncho chifukwa mapiritsi sangakhalebe othandizira pama cell a magazi kwa nthawi yokwanira. Vutoli lathetsedwa kwambiri pofika zida zatsopano za R-lipoic acid, kuphatikiza Bio-Enhanced® R-Lipoic Acid, yomwe GeroNova imapanga ndikunyamula ndikuyambiranso ku Doctor's Best and Life Extension. Mutha kuyesanso alpha lipoic acid ku Jarrow Formulas mapiritsi otulutsidwa.

Tikukumbutsaninso kuti chithandizo chachikulu cha matenda a shuga si mapiritsi, zitsamba, mapemphero, ndi zina zambiri, koma makamaka zakudya zamafuta ochepa. Sanjani mosamala ndikutsatira mwakhama pulogalamu yathu yothandizira matenda a shuga 1 kapena mtundu wa 2 wa matenda a shuga. Ngati muli ndi nkhawa ndi matenda a shuga, ndiye kuti mungasangalale kudziwa kuti ndi zovuta kusintha. Mukasinthasintha shuga m'magazi anu ndikamadya ochepera pang'ono, chizindikiro chonse cha neuropathy chimachoka pakapita miyezi ingapo mpaka zaka zitatu. Mwina kumwa alpha lipoic acid kungathandize kuti izi zitheke. Komabe, 80-90% ya mankhwalawa ndi zakudya zoyenera, ndipo zithandizo zina zonse zimangowonjezera. Mapiritsi ndi zochitika zina zitha kuthandizika mukachotsa chakudya chamafuta kwambiri m'zakudya zanu.

ALA ndi chiyani

Mwa zina mwazomwe zimayambitsa matenda ambiri, mankhwala amakono amatcha ma free radicals. Ma antioxidants achilengedwe opangidwa kuti athane nawo sangathe kuwaletsa. Ma antioxidants amapangidwa ndi thupi, komanso amitundu yosiyanasiyana kuchokera ku mawonekedwe apadera mpaka onse, koma osakwanira.

Ma antioxidants a Universal akuphatikizapo alpha lipoic acid (ALA). Kuchita kwake kosiyanasiyana kumawonekera mu izi:

• kulowa mkatikati mwa chotchinga cha magazi mu ubongo, chomwe sichinthu cha antioxidants ena,
• Sungunulani m'mafuta ndi m'madzi, zomwe sizachilendo kuphatikizana ndi mankhwala a antioxidant,
• mtundu wapadera wa alpha lipoic acid "ndikuwukitsa" ma antioxidants ena omwe sawonekeranso chizindikiro cha moyo. Amatha kuyambiranso coenzyme Q 10, mavitamini E ndi C, komanso glutathione.

Alpha lipoic acid amatchedwanso thioctic acid. Mayina onsewa anali odziwika kokha kwa akatswiri opapatiza. Masiku ano, kutchuka kwazomwe zakhala chuma cha ambiri, makamaka gawo lawo, lomwe pofufuza njira yochiritsira anthu oonda, ndemanga ndi umboni wowoneka bwino wa izi. Amadziwika ndi ambiri ngati antioxidant wapadziko lonse komanso njira popanda kuchiritsika kwa matenda ashuga a bongo. Kafukufuku woyamba wapangitsa asayansi kuti azitsimikiza za mapindu ake pakukhalitsa paubwana komanso polimbana ndi zovuta zomwe zimayenda ndi shuga wambiri.

ALA Katundu

• Pali anthu ambiri omwe amakonda kudya zakudya zamafuta kwambiri ndikuvutika ndimankhwala osiyanasiyana onenepa kwambiri, ndipo lipoic acid ndiwothandiza kwa aliyense, chifukwa amateteza maselo omwe amapanga insulin pakuwonongeka komanso kukula kwa matenda ashuga. Ndikungoyenera kuti thandizo limafika mofulumira.
• ku Europe, alpha lipoic acid yakhala ikugwiritsidwa ntchito pochiza matenda a shuga a matenda a shuga kwa zaka makumi atatu. Kafukufuku wachipatala adatsimikizira izi mu 71% ya odwala omwe adaperekedwa kuti atenge ALA,
• alpha lipoic acid ndi gawo la ma enzymes monga mbali zawo zopanda ma protein zomwe zimakhala coenzymes. Ma enzyme amenewa amathandizira kukhathamiritsa kwa glucose ndi mafuta acids, zomwe zimapangitsa kuti achepetse thupi. Imalowera mu minyewa yaubongo, imalepheretsa ntchito ya enzyme yomwe imayimira njala, yomwe imathandizanso pamunthuyo,
• alpha lipoic acid imapulumutsa chiwindi ku zoipa za mowa wa ethyl, imalepheretsa mawonekedwe a mafuta ndi izo. Alpha lipoic acid yochepetsa thupi amathandiza ndi steatosis - uku ndi kunenepa kwambiri kwa chiwindi, komwe sikunayambike chifukwa cha mowa, koma chifukwa cha kuperewera kwa zakudya m'thupi komanso kunenepa kwambiri,
• pakuyesera mbewa za labotale, kuthekera kwa alpha-lipoic acid kuti achepetse kukula kwa zolembera zam'magazi zotsekedwa. Inachepetsa chiwerengero cha triglycerides, chomwe ndi chiopsezo cha matenda a mtima ndi mtima. Zimakhudza mkhalidwe wa jini womwe umayang'anira cholesterol. Chiwerengero cha ma enzyme omwe amasunga ma free radicals chinakwera, ndipo izi zinachepetsa kupanga mafuta m'thupi. Koma mwa anthu, makina awa sanatsimikizidwebe,
• alpha lipoic acid linalake ndipo tikulephera mayendedwe a kusintha kwakukulu oxidation. Amathana ndi matenda a Alzheimer's, amathandizira kwambiri ntchito zamanjenje, makamaka kukumbukira, osati mwa nyama zokha. Mu gulu la nyama zomwe zinali ndi stroke, panali opulumuka ochulukirapo (nthawi 4) mwa iwo omwe adatenga ALA. Pogwiritsa ntchito alpha-lipoic acid, glutathione imapangidwanso, yomwe imapulumutsa ma neurons aubongo ku neurotoxins,
• Richard Passwater adavumbulutsa kuthekera kwa alpha-lipoic acid poletsa ntchito ya jini yomwe imapangitsa kukula kwa zotupa za khansa,
• Ndi zaka, kuchuluka kwa alpha-lipoic acid wopangidwa amachepetsa. Zotsatira zake, kuchuluka kwaunyamata kapena mankhwala a glutathione amatsika. Zimalepheretsa njira za glycolization ndi kuwonongeka kwa zimagwira ma cell, zomwe zimapangitsa kukalamba kwa thupi.

Zonse Zokhudza L-Carnitine

Chifukwa chake, lero, malingaliro ndi kuwunika kwa ambiri omwe akufuna kutukula unyamata wawo akutembenukira ku alpha lipoic acid. Itha kumwa mankhwalawa prophlaxis mwanjira zina, koma patatha zaka 50 madontho awa amatha ndipo akuyenera kuwonjezedwa.

Zizindikiro zogwiritsidwa ntchito

Lipoic acid - malangizo ogwiritsidwapo ntchito amalimbikitsa kumwa mankhwalawa matenda ambiri, monga:

• matenda a chiwindi
• matenda oncological
• ulemu,
• kutopa kwambiri.

Alpha lipoic acid imagwiritsidwanso ntchito masiku ano kuchiza kunenepa kwambiri.

Chikhalidwe kwa munthu, poganizira asidi omwe amapanga komanso omwe amabwera ndi chakudya, ndi 1-2 g. Popewa, mutha kutenga mpaka 100 mg / tsiku, ndipo pambuyo pa chikondwerero cha golide, mutha kutenga 300 mg ya ALA yonse.

Muyenera kudziwa kuti alpha-lipoic acid ndi amitundu iwiri: yochepetsedwa komanso oxidized. Zochita zoyambirira ndi zochulukirapo ka 1000 kuposa chachiwiri. Mukamalemba kapangidwe kake, ganizirani mtundu wake.

Zinthu zopezeka ndi alpha lipoic acid:

Ponena za kulandira ndi chakudya, sizigwira ntchito kuwonekera pazogulikazo, popeza zili ndi zochuluka. Mwachitsanzo, chiwindi (100 g) chimangokhala ndi 14 mg, ndipo kuchuluka kofanana kwa sipinachi ndikuchulukitsidwa katatu. Koma popeza simungathe kukonza zakudya zanu kuchokera ku sipinachi, chiwindi ndi mpunga, muyenera kumwa mapiritsi a mankhwala, omwe kuphatikiza pa lipoic acid ali ndi mankhwala ena okhala ndi katundu wofanana.

ALA ikufanizidwa ndi mavitamini a B, koma si mavitamini enieni, koma quasivitamin. Asidi amaphatikiza mwangwiro ndi thiamine ndi mavitamini a B eni.

Ndikusowa kwa ALA kuchokera ku chakudya, pali njira ina - kutenga ma analogu a mankhwala.

Contraindication

Mutha kumwa alpha lipoic acid, koma pambuyo pa contraindication amadziwika:

• ana osakwana zaka 6
• pakati ndi kuyamwa
• anthu omwe ali ndi chidwi ndi zomwe zikuchokera.

Zotsatira zoyipa:

• mutu
• kusanza
• nseru
• kutsegula m'mimba
• zinthu zoyipa.

Momwe mungachepetse chilakolako chofuna kudya ndikuchotsa njala

Pambuyo pa kayendetsedwe ka iv, mavuto a kupuma, kuchuluka kwachuma kwachuma, komwe kumadutsa popanda chithandizo chamankhwala, kutha kuwonedwa. Zowopsa zomwe sizingachitike:

• magazi
• zotupa pa mucous nembanemba,
• kukokana.

Kwa odwala matenda ashuga, alpha lipoic acid amangoikidwa moyang'aniridwa ndi achipatala. Nthawi yomweyo, shuga amawunika kuti apewe kukomoka kwa hypoglycemic.

Mitundu ya Lipoic Acid

Alpha lipoic acid imatha kukhala m'mapiritsi kapena makapisozi. Makapisozi amachokera ku 12 mpaka 600 μg yogwira ntchito. ALA imapezekanso mu njira yokhazikika yothetsera, komwe mapangidwe ake amakhala okonzekera kulowetsedwa ndi kulowetsedwa kwamkati. Mlingo nthawi zambiri umadziwika ndi dokotala. Mwa mitundu yayikulu ya neuropathy, jakisoni wa mankhwala ndi mankhwala. Mu thupi, alpha lipoic acid imatengedwa mwachangu kenako imayatsidwa ndi kwamikodzo.

Ma analogi a ALA amadziwika, monga:

ALA analogues amalembedwa:

• kufunika kokonza chithokomiro,
• monga zolimbitsa ubongo,
• kukonza magwiridwe antchito owonera
• poyizoni, kuphatikizapo mchere wamafuta azitsulo,
• matenda a chiwindi amitundu yosiyanasiyana,
• atherosulinosis,
• kutayika kwa miyendo.

Osamamwa analogi ya ALA yokhala ndi zakumwa zoledzeretsa komanso mankhwala okhala ndi chitsulo.

ALA ya kuwonda

Kuwerenga ndemanga, titha kunena kuti tikataya thupi kokha lipoic acid sangathe kuchita. Alpha-lipoic acid yochepetsa thupi imaphatikizapo kagayidwe ka mafuta, koma popanda ntchito zamagalimoto simungathe kuthana ndi mafuta amthupi. Ndikwabwino kuyambitsa njira yochepetsera kulemera ndi alpha lipoic acid mukakumana ndi akatswiri azakudya. Amapatsidwa mlingo wa munthu winawake, kutengera momwe thupi lake alili komanso kulemera kwake. Wachikulire wathanzi amafunika pafupifupi 50 mg ya ALA patsiku. Alpha lipoic acid yochepetsera thupi imapezeka m'ma antioxidant, m'mankhwala osiyanasiyana komanso zakudya zamagetsi.

Alpha lipoic acid imatha kulembedwa ndi L-carnitine, yomwe imayendetsa metabolism yamafuta.

The fanizo la mankhwala alpha-lipoic acid amawonetsedwa, molingana ndi mawu omasulira azachipatala, omwe amatchedwa "ma syonyms" - mankhwala osinthika omwe ali ndi chinthu chimodzi kapena zingapo zomwe zimagwira mothandizidwa ndi zomwe zimachitika mthupi. Mukamasankha mawu ofananitsa, osangoganizira mtengo wawo, komanso dziko lakapangidwe ndi mbiri ya wopanga.

Mndandanda wazofananira

Tcherani khutu! Mndandandandawu umakhala ndi ma syonms a Alpha Lipoic Acid, omwe ali ndi mawonekedwe ofanana, kotero mutha kusankha nokha m'malo mwake, mukumaganizira mawonekedwe ndi mankhwalawa omwe mankhwalawa adamwa ndi dokotala. Perekani zokonda kwa opanga ku USA, Japan, Western Europe, komanso makampani odziwika bwino ochokera ku Eastern Europe: Krka, Gideon Richter, Actavis, Aegis, Lek, Hexal, Teva, Zentiva.

Kutulutsa Fomu (ndi kutchuka)	Mtengo, pakani.
Alpha lipoic acid
ANTI - ZAM'MBUYO 100 mg kapisozi, 30 ma PC.	293
Alpha-Lipoic Acid
Kuphatikiza
Berlition 300
Ampoules 300 mg, 12 ml, ma PC 5.	497
Pakamlomo, mapiritsi 300 mg, 30 ma PC.	742
Berlition 600
Ampoules 600 mg, 24 ml, ma PC 5.	776
Lipamide
Zolemba Pamimba za Lipamide, 0,025 g
Lipoic acid
Lipoic acid
30mg No. 30 tabu p / o Kvadrat - S (Kvadrat - S OOO (Russia)	79
Lipoic Acid Mapiritsi Ovomerezeka
Lipothioxone
Neuro lipone
300mg No. 30 zisoti (Farmak OAO (Ukraine)	252.40
Oktolipen
300mg zipewa N30 (Pharmstandard - Leksredstva OAO (Russia)	379.70
30mg / ml amp 10ml N10 (Pharmstandard - UfaVITA OJSC (Russia)	455.50
30mg / ml 10ml No. 10 yang'anani pakukonzekera njira yothetsera kulowetsedwa (Pharmstandard - Ufa vit.z - d (Russia)	462
600mg No. 30 tabu (Pharmstandard - Tomskkhimfarm OJSC (Russia)	860.30
Ndale
Tiogamma
P - p wa kulowetsedwa 12 mg / ml 50 ml fl N1. (Solufarm GmbH & Co.KG (Germany)	219.60
P - r d / inf 12mg / ml 50ml fl No. 1 (Solufarm GmbH ndi Co.KG (Germany)	230.50
Tab 600mg N30 (Artezan Pharma GmbH & Co.KG (Germany)	996.20
600mg No. 30 tabu p / o (Dragenofarm Apotheker Puschl GmbH (Germany)	1014.10
Njira yothetsera kulowetsedwa 12 mg / ml 50 ml fl N1 (Solufarm GmbH ndi CoKG (Germany)	2087.80
Thioctacid 600
Thioctacid 600 T
Ampoules 600 mg, 24 ml, ma PC 5.	1451
Thioctacid BV
Mapiritsi a 600 mg, ma PC 100.	2928
Thioctic acid
Thioctic acid
Thioctic Acid-Vial
Tiolepta
Tab 300mg N30 (Canonfarm Production CJSC (Russia)	393.60
Tab p / pl About 600mg N60 (Canonfarm Production CJSC (Russia)	1440.10
Thiolipone
Mapiritsi okutidwa filimu 300 mg, 30 ma PC.	300
Ampoules 300 mg, 10 ml, ma PC 10.	383
Mapiritsi okutidwa filimu 600 mg, 30 ma PC.	641
Espa lipon
600mg No. 30 tabu (Pharma Wernigerode GmbH (Germany)	694.10
600 mg / 24 ml amp N1 (ESPARMA GmbH (Germany)	855.40
600 mg / 24 ml amp N5 (ESPARMA GmbH (Germany)	855.70

Alendo 22 adanenanso za kuchuluka kwa chakudya tsiku lililonse

Kodi ndiyenera kumwa alpha lipoic acid kangati?
Ambiri omwe amayankhidwa nthawi zambiri amamwa mankhwalawa 1 kamodzi patsiku. Ripotilo likuwonetsa kuti anthu ena omwe amayankha mankhwalawa amamwa kangati

Mamembala	%
Kamodzi patsiku	15	68.2%
Katatu patsiku	3	13.6%
2 pa tsiku	3	13.6%
4 pa tsiku	1	4.5%

Alendo 55 adafotokoza

Mamembala	%
501mg-1g	22	40.0%
101-200mg	11	20.0%
201-500mg	11	20.0%
51-100mg	8	14.5%
11-50mg	3	5.5%

Alendo asanu adanenanso za kumaliza ntchito

Zimatenga nthawi yayitali bwanji kuti munthu atenge alpha lipoic acid kuti amve bwino?
Ochita kafukufukuwo nthawi zambiri atatha miyezi itatu adasintha.Koma izi sizingafanane ndi nthawi yomwe musinthe. Funsani dokotala wanu kuti mupeze mankhwalawa kwa nthawi yayitali bwanji. Gome ili pansipa likuwonetsa zotsatira za kafukufuku pa zoyambira kuchitapo kanthu.

Mamembala	%
3 mwezi	2	40.0%
2 masiku	1	20.0%
Masiku 5	1	20.0%
3 masiku	1	20.0%

Alendo asanu ndi mmodzi adanena nthawi yakulandiridwayo

Nthawi yabwino kumwa alpha lipoic acid: pamimba yopanda kanthu, isanachitike, itatha, kapena ndi chakudya?
Ogwiritsa ntchito mawebusayiti nthawi zambiri amati amamwa mankhwalawa pamimba yopanda kanthu. Komabe, adotolo atha kuvomereza nthawi ina. Ripotilo likuwonetsa pamene ena onse omwe adawafunsidwa amamwa mankhwalawo.

Wopanga

Zomwe zili patsamba lino zinatsimikiziridwa ndi katswiri wazachipatala Vasilieva E.I.

Ziwalo zaumunthu sizitha kupanga mphamvu mokwanira bwino kuchokera ku chakudya chamafuta kapena mafuta,
popanda thandizo la lipoic acid kapena, mwanjira ina, thioctic acid.
Zakudya izi zimatchulidwa ngati antioxidant yomwe imathandizira mwachindunji kuteteza maselo kuti asafe ndi mpweya wa oxygen. Kuphatikiza apo, imapatsanso thupi ndi ma antioxidants angapo, kuphatikiza mavitamini C ndi E, omwe sangatengeke pakadalibe lipoic acid.

Alpha lipoic acid - gulu lachilengedwe lomwe limakhudzidwa ndi metabolism yamphamvu, mu 1950s adapeza kuti ndi imodzi mwazinthu za kayendedwe ka Krebs. Alfa-lipoic acid ndi antioxidant wamphamvu wachilengedwe wamphamvu wokhala ndi katundu wodabwitsa pochiza komanso kupewa matenda osiyanasiyana.

A gawo la lipoic acid ndi luso lochita zonse pamadzi ndi pamaziko a sing'anga.

Ntchito ya Acid

Kupanga kwa magetsi - asidi awa amapeza malo ake kumapeto kwa njirayi, amatchedwa glycolysis, momwe maselo amapanga mphamvu kuchokera ku shuga ndi wowuma.

Kupewa kuwonongeka kwa maselo ndi gawo lofunikira la ntchito ya antioxidant komanso kuthekera kwake popewa kuchepa kwa mpweya ndi kuwonongeka kwa maselo.

Amathandizira kugaya kwa mavitamini ndi ma antioxidants - mankhwala a lipoic acid amalumikizana ndi madzi sungunuka (vitamini C) ndi zinthu zosungunuka zamafuta (vitamini E), chifukwa chake amathandizira kupewa kuchepa kwa mavitamini onse awiri. Ma antioxidants ena monga coenzyme Q, glutathione ndi NADH (mtundu wa nikotini acid) nawonso amadalira kupezeka kwa lipoic acid.

Momwe mungagwiritsire lipoic acid pakuchepetsa thupi?

Mukakula, chinthucho sichimapangidwa ndi thupi, ndiye ngati mukufuna kukhala bwino, lowetsani asidi menyu.

Malamulo otenga lipoic acid pakuchepetsa:

• Osamatenga zinthu zomwe zimakhala ndi chitsulo chambiri ndi mankhwalawa
• Chepetsa kudya kwanu nkhuku ndi ng'ombe chiwindi, maapulo ndi buckwheat
• Mankhwala amalimbikitsa mphamvu ya mankhwala ena, chifukwa musanagwiritse ntchito mapiritsi aliwonse dokotala wanu
• Vutoli limaphwanya cholesterol yoyipa, chifukwa chake amalimbikitsidwa kwa anthu omwe ali ndi vuto la matenda oopsa
• Mowa umalepheretsa kuyamwa kwa zinthu, kotero kumwa vinyo ndi mankhwalawo kulibe ntchito
• Gawani wogawana kuchuluka kwa zinthu zitatu zochuluka
• Imwani mankhwalawa ola limodzi mutatha kudya

Mankhwala si mankhwala, ndi othandizira ena omwe amathandiza thupi kuthana ndi kuwonongeka kwa mafuta mwachangu.

Lipoic acid akusowa

Popeza lipoic acid imagwirizana kwambiri ndi michere yambiri komanso ma antioxidants, ndizovuta kudziwa kudalira kwa zizindikiro za kuperewera kwa asidiyu wina ndi mnzake. Chifukwa chake, zizindikirozi zimatha kuphatikizidwa ndi chizindikiro cha kuperewera kwa zinthuzi, kuchepa mphamvu kwa chitetezo m'thupi komanso kuwonjezeka kwa chimfine ndi matenda ena, mavuto a kukumbukira, kuchepa kwa minofu, komanso kulephera kukhazikika.

Amapezeka mu mitochondria (mayunitsi opanga mphamvu) a ma cell a nyama, ndipo anthu omwe samadya zopangidwa ndi nyama ali pachiwopsezo chachikulu cha kuchepa kwa asidi awa. Ogulitsa masamba omwe samadya masamba obiriwira omwe amawoneka nawonso amakhala ndi ngozi zofananazo, chifukwa chloroplasts amakhala ndi lipoic acid yambiri.

Zimateteza mapuloteni pakukalamba; anthu achikulire nawonso ali pachiwopsezo chachikulu cha kuperewera.

Momwemonso, chifukwa lipoic acid imagwiritsidwa ntchito kuwongolera shuga, odwala matenda ashuga ali ndi chiwopsezo chachikulu cha kuchepa.

Anthu omwe sakudya mokwanira mapuloteni ndi ma amino acid okhala ndi sodium ali pachiwopsezo chachikulu chifukwa ma thioctic acid amatenga ma atomu a sulfure kuchokera ku maamino acid awa.

Popeza thioctic acid amalowetsedwa makamaka m'mimba Anthu omwe ali ndi chimbudzi kapena ochepa m'mimba amtundu nawonso ali pachiwopsezo chowonjezeka cha kuchepa.

Zotsatira zoyipa

Zotsatira zoyipa, ndikotheka kuti nseru kapena kusanza, kupweteka m'mimba ndi m'mimba zimachitika. Nthawi zina, thupi lawo siligwirizana, monga zotupa pakhungu, kuyabwa ndi urticaria. Chifukwa cha kuyamwa kwamphamvu kwa shuga, shuga m'magazi amachepetsedwa. Zotsatira zoyipa za lipoic acid, zizindikiro zomwe zimafanana ndi hypoglycemia, kupweteka mutu, thukuta, ndi chizungulire zimawonedwa.

Magwero a thioctic acid

Lipoic acid amapezeka muzakudya monga zobiriwira zobiriwira zomwe zimakhala ndi chloroplasts yambiri. Ma chloroplasts ndi malo ofunikira opangira mphamvu zamafuta m'mimba ndipo amafunika lipoic acid kuti agwire. Pachifukwa ichi, broccoli, sipinachi ndi masamba ena obiriwira masamba ndiwo magwero a chakudya cha asidi.

Zogulitsa zanyama - mitochondria ali ndi mfundo zofunikira pakupanga mphamvu mu nyama, awa ndi malo abwino osakira lipoic acid. Organs okhala ndi mitochondria yambiri (monga mtima, chiwindi, impso, ndi mafupa am'mimba) ndi magwero abwino a lipoic acid.

Thupi laumunthu limatulutsa alpha lipoic acid, koma ochepa.

Zothandiza pioctic acid

Mapindu a lipoic acid ndi awa:

• Imachepetsa kupsinjika kwa oxidative mthupi chifukwa cha zochita zamphamvu za antioxidant,
• Amasintha magawo ena a metabolic syndrome - kuphatikiza kwa zinthu zoopsa zomwe zimawonjezera mwayi wokhala ndi matenda a shuga,
• Amachepetsa kuthamanga kwa magazi
• Imachepetsa kukana insulin
• Amasintha mbiri ya lipid,
• Amachepetsa thupi
• Amasintha mphamvu ya insulin,
• Amachepetsa kuopsa kwa matenda ashuga a polyneuropathy,
• Imaletsa kuwoneka kwamatope,
• Amasintha magawo owonekera mu glaucoma,
• Imachepetsa kuwonongeka kwa ubongo pambuyo pa sitiroko,
• Amachepetsa kuchepa kwa mafupa chifukwa cha anti-yotupa katundu
• Amachotsa zitsulo zolemera m'thupi,
• Kuchepetsa pafupipafupi komanso kuuka kwa zovuta za migraine,
• Amasintha kapangidwe kake ndi khungu.

Kupanga Thupi Lipoic Acid

Kuchita masewera olimbitsa thupi kumathandizira kusintha kwakukulu pakuwongolera kuchuluka kwa shuga, kumva kwa insulin komanso metabolism.

Pakufufuza komwe ophunzira adatenga 30 mg ya alpha lipoic acid pa kilogalamu ya kulemera kwa thupi ndikuphunzitsidwa kupirira, zinatsimikiziridwa kuti kuphatikiza uku kumapangitsa chidwi cha insulin komanso kuyankha kwamthupi kwakukulu kwambiri kuposa aliyense payekhapayekha. Kutsika kwa oxidative nkhawa ndi triglycerides mu minofu kunadziwika.

Thupi lathu limatha kupanga alpha lipoic acid kukhala mafuta acids ndi cysteine, koma nthawi zambiri kuchuluka kwawo sikokwanira. Zakudya zopatsa thanzi ndi njira yabwino yothanirana mosavuta.

Ndikwabwino kuyamba ndi Mlingo wocheperako, ndikuwonjezera pang'onopang'ono kuwona momwe lipoic acid amakhudzira thupi.

Ngakhale mulingo waukulu kuposa momwe analimbikitsira, mavuto sanakhazikike.

Kafukufuku wachitika ndi anthu omwe amatenga Mlingo wambiri - 2400 mg tsiku lililonse, pakatha miyezi 6 ya 1800mg-2400mg, ngakhale ali ndi Mlingo wotere, palibe zotsatira zoyipa zomwe zidapezeka.

Zitsanzo za alpha lipoic acid

Ndi mlingo wa 200-600 mg patsiku, insulin sensitivity ichulukitsa ndipo kuchuluka kwa shuga m'magazi kumachepa. Mlingo womwe uli pansi pa 200 mg sutulutsa zotsatira zowoneka bwino kuposa katundu wa antioxidant. Mlingo wa 1200 mg - 2000 mg uthandizira kuchepa kwamafuta.

Ndikwabwino kugawanitsa mankhwalawo kangapo ndikuwamwa masana. Mwachitsanzo, ngati mumatenga 1000 mg patsiku, ndiye:

• 300 mg mphindi 30 asanadye chakudya cham'mawa
• 200 mg mphindi 30 asanadye,
• 300 mg ataphunzitsidwa
• 200 mg mphindi 30 asanadye.

Momwe mungagwiritsire lipoic acid kuti muchepetse kunenepa

Alpha lipoic acid amathandiza amayi ndi amuna kuti achepetse thupi. Kafukufuku wa 2011 adapeza kuti anthu onenepa kwambiri omwe amatenga 1800 mg ya alpha lipoic acid patsiku amachepetsa kwambiri kuposa anthu omwe amagwiritsa ntchito mapiritsi a placebo. Kafukufuku wina, womwe adachitika mu 2010, adawonetsa kuti mlingo wa 800 mg tsiku lililonse kwa miyezi inayi ungayambitse kuchepa kwa 8-9% ya thupi.

Ngakhale zotsatira zabwino za kafukufuku, alpha lipoic acid si piritsi lazakudya. Mu maphunziro, alpha lipoic acid wagwiritsidwa ntchito ngati chowonjezera pophatikiza ndi zakudya zama calorie ochepa. Kuphatikizidwa ndi zakudya zopatsa thanzi komanso kuchita masewera olimbitsa thupi pafupipafupi, thioctic acid imakuthandizani kuti muchepetse kunenepa kwambiri kuposa zopanda zowonjezera.

Momwe mungagwiritsire lipoic acid kuti muchepetse kunenepa. Kusankha koyenera kungakhale kukaonana ndi dotolo kapena kukaonana ndi dokotala. Adzakhazikitsa pafupifupi kuchuluka kwa mankhwalawa tsiku lililonse, omwe angathandize kuchepetsa thupi. Mlingo umatengera magawo anu - kulemera kwake komanso thanzi lanu. Thupi lathanzi silimafunikira kuposa 50 mg ya mankhwala. Chochepera chotsika kwambiri ndi 25 mg.

Nthawi yogwira mankhwala ochepetsa thupi poyerekeza ndi ndemanga:

• Tengani lipoic acid wochepetsa thupi musanadye chakudya cham'mawa kapena mutangomaliza kudya,
• Pambuyo pochita masewera olimbitsa thupi, i.e. nditaphunzitsidwa,
• Pa chakudya chomaliza.

Kuti muwonjezere mphamvu ya zowonjezerazo, dziwani pang'ono pompopompo: ndibwino kuphatikiza kudya kwa lipoic acid kuti muchepetse thupi komanso kuyamwa kwa chakudya chamafuta. Awa ndi madeti, pasitala, mpunga, semolina kapena phala la buckwheat, uchi, mkate, nyemba, nandolo ndi zinthu zina zamafuta.

Kwa akazi, lipoic acid yochepetsa thupi imakonda kuphatikizidwa ndi levocarnitine, yomwe imawonetsedwa mu malangizo ogwiritsira ntchito ngati L-carnitine kapena carnitine wokha. Ichi ndi amino acid pafupi ndi mavitamini B, ntchito yayikulu yomwe ndi kukhazikitsa mafuta kagayidwe. Carnitine imathandiza thupi kugwiritsa ntchito mphamvu zamafuta mwachangu, limachotsa m'maselo. Pogula mankhwala ochepetsa thupi, samalani ndi mawonekedwe. Zakudya zowonjezera zambiri zimakhala ndi carnitine ndi alpha lipoic acid, yomwe ndi yabwino kwa iwo omwe akuchepetsa. Popeza pamenepa simungaganizire kuti ndi liti ndipo ndi ziti mwa zinthuzi zomwe zili bwino kutenga.

Kutenga thioctic acid kumapangitsa kuti thupi lathu lizitha kugwira bwino ntchito komanso kukhala ndi mphamvu. Zimathandizira kusintha zakudya zamagetsi kukhala mphamvu. Kuti muwonjezere metabolism yanu ndikuwotcha mafuta ochulukirapo, ndikulimbikitsidwa kutenga 300 mg ya lipoic acid tsiku lililonse.

Ntchito khungu la nkhope

Mphamvu ya antioxidant komanso anti-yotupa ya alpha lipoic acid imagwira ntchito zodabwitsa zikafika pochepetsa zizindikiro zowoneka za ukalamba. Lipoic acid ndiwothandiza komanso wodabwitsa antioxidant ndipo ali ndi mphamvu nthawi 400 kuposa mavitamini C ndi E. Mukamagwiritsidwa ntchito kunja, alpha lipoic acid imakhala yopindulitsa pakhungu - imachepetsa puffiness ndi mabwalo amdima pansi pa maso, kutupa ndi nkhope.Popita nthawi, khungu limawoneka bwino, ndikuwonjezera kupanga kwa nitric oxide, ma pores amachepetsedwa, makwinya amakhala osawonekera kwenikweni.

Zitha kukhala chifukwa cha matenda ambiri. Zina mwa izo ndizowopsa pamkhalidwe waumoyo wa anthu ndi moyo, chifukwa chiwalo ichi sichimangotulutsa bile, chofunikira pakugaya chakudya, komanso fayilo yachilengedwe ya thupi lathu yomwe imatsuka magazi pazinthu zovulaza pogwiritsa ntchito zinthu zazipanga zomwe zimapangidwira, zomwe zimakhudzidwa kagayidwe.

Pakadali pano, mankhwala sangamupatse wodwalayo mankhwala ndi njira zomwe zingapangitse kuti pakhale zopanda chiwalo chofunikira. Ngakhale kupatsirana kwa chiwindi kapena kuchotsedwa kwake pang'ono kumabweretsa zovuta zambiri, zoperewera komanso kufunikira kochita maphunziro ovuta aumoyo kwa wodwala.

Munkhaniyi, tikufotokozerani za zazikulu za zovuta za chiwindi ndi mankhwala monga lipoic (kapena thioctic) acid. Zimatha kukhala ndi chothandiza pakugwira ntchito yofunikira pa chiwalo chofunikirachi matenda monga hepatitis ndi hepatoses.

Ndi zizindikiro ziti zomwe zikuwonetsa mavuto a chiwindi?

Matenda a chiwindi amatha kuwonekera ndi zizindikiro zosiyanasiyana. Nthawi zambiri izi ndi:

• utoto wa bulauni thupi ngati mawanga,
• fungo loipa la pakhungu
• rosacea
• mpweya wabwino
• kupweteka kapena kulemera mu hypochondrium yoyenera.

Kodi lipoic acid imakhudza bwanji chiwindi?

Lipoic acid adayamba kupatulidwa yisiti ndi chiwindi mu 1948. Kuphatikizika kwake kunachitika mu 1952, ndipo zitatha izi, maphunziro adayamba pazokhudza izi m'magazi a shuga. Zotsatira zake, mu 1977, asayansi adapeza kuti lipoic acid imatha kukhala ndi zotsatira zabwino osati pancreas, komanso chiwindi.

M'matenda akuluakulu a chiwindi, anthu nthawi zonse amavutika ndi zovuta za mayendedwe omasuka pamatupi awo. Kuti zisasokoneze, ma antioxidants amafunikira, omwe amafunikira kuti azilowetsedwa m'thupi. Chimodzi mwazinthu izi ndi lipoic acid - coenzyme ya michere ina yomwe imayendetsa mafuta ndi metabolism ya carbohydrate.

Kupereka lipotropic zotsatira, antioxidant iyi imaletsa kudzikundika kwamphamvu kwamafuta m'maselo a chiwindi ndi kuchepa kwawo kwamafuta. Izi zimatheka chifukwa chakuti lipoic acid imatha kuchepetsa kumwa kwa intrahepatic antioxidant monga glutathione.

Kodi lipoic acid amalowa bwanji mthupi lathu?

Thupi laumwini palokha limatulutsa lipoic acid pang'ono. Kwenikweni, amalowa ndi chakudya.

Lipoic acid amapezeka muzinthu zotsatirazi:

• mkaka watsopano - 500-1300 mcg,
• ma mpunga - 220 mcg,
• chiwindi cha ng'ombe - ma 700 mg ma mailogalamu ochepa,
• offal - 1 chikwi, mcg,
• sipinachi amadyera - 100 mcg,
• ng'ombe - 725 mcg,
• kabichi yoyera - 150 mcg.

Zochepa, antioxidant iyi imapezekanso mu zakudya zina:

Nthawi zambiri, tsiku ndi tsiku mlingo wa antioxidant wa anthu athanzi ndi 10-50 mg. Ndi matenda a chiwindi, ayenera kukhala osachepera 75 mg, ndipo odwala matenda ashuga - 200-600 mg. Ndi kuchuluka kosakwanira kwa vitamini-ngati ichi, chiwindi chimakhala ndi mafuta ochulukirapo, ndipo mkhalidwe wotere ungayambitse kukula kapena kufalikira kwa matenda. Mutha kubwezeretsanso zosunga za antioxidant iyi mwa kuwona malamulo a zakudya zabwino kapena mwa kumwa mankhwala okhala ndi lipoic acid.

Mlingo wa ana ndi akulu

• Ana a zaka zopitilira 6 - 12-24 mg katatu patsiku,
• akuluakulu - 50 mg 3-4 pa tsiku.

Mankhwala ayenera kumwedwa pambuyo chakudya. Njira yovomerezeka ndi masiku 20-30. Ngati ndi kotheka, dokotala angalimbikitse kubwereza pambuyo pa mwezi. Odwala omwe amamwa mankhwalawa amalangizidwa kuti aziwonetsetsa kuti ali ndi shuga.

Kuyanjana kotheka ndi mankhwala ena

• imayambitsa zotsatira za insulin kapena mankhwala a hypoglycemic pakuyambitsa pakamwa,
• zimatayika pakaphatikizidwa ndi Mowa,
• Imafooketsa zochita za chisplatin,
• zimatha kusokoneza kuyamwa mwachizolowezi kwa chitsulo, magnesium ndi calcium zomwe zili m'makonzedwe (ndi kugwiritsidwa ntchito molumikizana ndi mankhwalawa, nthawi yapakati pakati Mlingo wa mankhwala uyenera kukhala osachepera maola 2).

Kutulutsa Fomu

Malo osungira

Tsiku lotha ntchito

Migwirizano ya Tchuthi

Wopanga

Zomwe zili patsamba lino zinatsimikiziridwa ndi katswiri wazachipatala Vasilieva E.I.

Ziwalo zaumunthu sizitha kupanga mphamvu mokwanira bwino kuchokera ku chakudya chamafuta kapena mafuta,
popanda thandizo la lipoic acid kapena, mwanjira ina, thioctic acid.
Zakudya izi zimatchulidwa ngati antioxidant yomwe imathandizira mwachindunji kuteteza maselo kuti asafe ndi mpweya wa oxygen. Kuphatikiza apo, imapatsanso thupi ndi ma antioxidants angapo, kuphatikiza mavitamini C ndi E, omwe sangatengeke pakadalibe lipoic acid.

Alpha lipoic acid - gulu lachilengedwe lomwe limakhudzidwa ndi metabolism yamphamvu, mu 1950s adapeza kuti ndi imodzi mwazinthu za kayendedwe ka Krebs. Alfa-lipoic acid ndi antioxidant wamphamvu wachilengedwe wamphamvu wokhala ndi katundu wodabwitsa pochiza komanso kupewa matenda osiyanasiyana.

A gawo la lipoic acid ndi luso lochita zonse pamadzi ndi pamaziko a sing'anga.

Ntchito ya Acid

Kupanga kwa magetsi - asidi awa amapeza malo ake kumapeto kwa njirayi, amatchedwa glycolysis, momwe maselo amapanga mphamvu kuchokera ku shuga ndi wowuma.

Kupewa kuwonongeka kwa maselo ndi gawo lofunikira la ntchito ya antioxidant komanso kuthekera kwake popewa kuchepa kwa mpweya ndi kuwonongeka kwa maselo.

Amathandizira kugaya kwa mavitamini ndi ma antioxidants - mankhwala a lipoic acid amalumikizana ndi madzi sungunuka (vitamini C) ndi zinthu zosungunuka zamafuta (vitamini E), chifukwa chake amathandizira kupewa kuchepa kwa mavitamini onse awiri. Ma antioxidants ena monga coenzyme Q, glutathione ndi NADH (mtundu wa nikotini acid) nawonso amadalira kupezeka kwa lipoic acid.

Lipoic acid akusowa

Popeza lipoic acid imagwirizana kwambiri ndi michere yambiri komanso ma antioxidants, ndizovuta kudziwa kudalira kwa zizindikiro za kuperewera kwa asidiyu wina ndi mnzake. Chifukwa chake, zizindikirozi zimatha kuphatikizidwa ndi chizindikiro cha kuperewera kwa zinthuzi, kuchepa mphamvu kwa chitetezo m'thupi komanso kuwonjezeka kwa chimfine ndi matenda ena, mavuto a kukumbukira, kuchepa kwa minofu, komanso kulephera kukhazikika.

Amapezeka mu mitochondria (mayunitsi opanga mphamvu) a ma cell a nyama, ndipo anthu omwe samadya zopangidwa ndi nyama ali pachiwopsezo chachikulu cha kuchepa kwa asidi awa. Ogulitsa masamba omwe samadya masamba obiriwira omwe amawoneka nawonso amakhala ndi ngozi zofananazo, chifukwa chloroplasts amakhala ndi lipoic acid yambiri.

Zimateteza mapuloteni pakukalamba; anthu achikulire nawonso ali pachiwopsezo chachikulu cha kuperewera.

Momwemonso, chifukwa lipoic acid imagwiritsidwa ntchito kuwongolera shuga, odwala matenda ashuga ali ndi chiwopsezo chachikulu cha kuchepa.

Anthu omwe sakudya mokwanira mapuloteni ndi ma amino acid okhala ndi sodium ali pachiwopsezo chachikulu chifukwa ma thioctic acid amatenga ma atomu a sulfure kuchokera ku maamino acid awa.

Popeza thioctic acid amalowetsedwa makamaka m'mimba Anthu omwe ali ndi chimbudzi kapena ochepa m'mimba amtundu nawonso ali pachiwopsezo chowonjezeka cha kuchepa.

Zotsatira zoyipa

Zotsatira zoyipa, ndikotheka kuti nseru kapena kusanza, kupweteka m'mimba ndi m'mimba zimachitika. Nthawi zina, thupi lawo siligwirizana, monga zotupa pakhungu, kuyabwa ndi urticaria. Chifukwa cha kuyamwa kwamphamvu kwa shuga, shuga m'magazi amachepetsedwa.Zotsatira zoyipa za lipoic acid, zizindikiro zomwe zimafanana ndi hypoglycemia, kupweteka mutu, thukuta, ndi chizungulire zimawonedwa.

Zizindikiro zogwiritsidwa ntchito

Imagwira ntchito yofunika kwambiri popewa komanso kuchiza matenda ambiri. Zisonyezero zogwiritsira ntchito lipoic acid:

• Mphaka
• Matenda otopa kwambiri
• Kutopa kwakutalika kwa minofu
• Matenda a shuga
• Glaucoma
• Edzi
• Hypoglycemia,
• Kulolerana shuga
• Kukana insulini
• Matenda a chiwindi
• Khansa ya m'mawere
• Matenda a neurodegenerative mu ana,
• Matenda amagetsi.

Pazambiri zothandizira pazakudya zopatsa thanzi, lipoic acid ili mu mawonekedwe a alpha lipoic acid. Pambuyo polowa m'thupi, imasandulika mawonekedwe ena - dihydrolipoic acid kapena DHLA. Mapiritsi nthawi zambiri amapezeka mu Mlingo wa 25-50 mg, amakhulupirira kuti malire a tsiku ndi tsiku ndi 100 mg, pokhapokha amalimbikitsidwa makamaka ndi matenda ena, monga matenda a shuga.

Magwero a thioctic acid

Lipoic acid amapezeka muzakudya monga zobiriwira zobiriwira zomwe zimakhala ndi chloroplasts yambiri. Ma chloroplasts ndi malo ofunikira opangira mphamvu zamafuta m'mimba ndipo amafunika lipoic acid kuti agwire. Pachifukwa ichi, broccoli, sipinachi ndi masamba ena obiriwira masamba ndiwo magwero a chakudya cha asidi.

Zogulitsa zanyama - mitochondria ali ndi mfundo zofunikira pakupanga mphamvu mu nyama, awa ndi malo abwino osakira lipoic acid. Organs okhala ndi mitochondria yambiri (monga mtima, chiwindi, impso, ndi mafupa am'mimba) ndi magwero abwino a lipoic acid.

Thupi laumunthu limatulutsa alpha lipoic acid, koma ochepa.

Zothandiza pioctic acid

Mapindu a lipoic acid ndi awa:

• Imachepetsa kupsinjika kwa oxidative mthupi chifukwa cha zochita zamphamvu za antioxidant,
• Amasintha magawo ena a metabolic syndrome - kuphatikiza kwa zinthu zoopsa zomwe zimawonjezera mwayi wokhala ndi matenda a shuga,
• Amachepetsa kuthamanga kwa magazi
• Imachepetsa kukana insulin
• Amasintha mbiri ya lipid,
• Amachepetsa thupi
• Amasintha mphamvu ya insulin,
• Amachepetsa kuopsa kwa matenda ashuga a polyneuropathy,
• Imaletsa kuwoneka kwamatope,
• Amasintha magawo owonekera mu glaucoma,
• Imachepetsa kuwonongeka kwa ubongo pambuyo pa sitiroko,
• Amachepetsa kuchepa kwa mafupa chifukwa cha anti-yotupa katundu
• Amachotsa zitsulo zolemera m'thupi,
• Kuchepetsa pafupipafupi komanso kuuka kwa zovuta za migraine,
• Amasintha kapangidwe kake ndi khungu.

Kupanga Thupi Lipoic Acid

Kuchita masewera olimbitsa thupi kumathandizira kusintha kwakukulu pakuwongolera kuchuluka kwa shuga, kumva kwa insulin komanso metabolism.

Pakufufuza komwe ophunzira adatenga 30 mg ya alpha lipoic acid pa kilogalamu ya kulemera kwa thupi ndikuphunzitsidwa kupirira, zinatsimikiziridwa kuti kuphatikiza uku kumapangitsa chidwi cha insulin komanso kuyankha kwamthupi kwakukulu kwambiri kuposa aliyense payekhapayekha. Kutsika kwa oxidative nkhawa ndi triglycerides mu minofu kunadziwika.

Thupi lathu limatha kupanga alpha lipoic acid kukhala mafuta acids ndi cysteine, koma nthawi zambiri kuchuluka kwawo sikokwanira. Zakudya zopatsa thanzi ndi njira yabwino yothanirana mosavuta.

Ndikwabwino kuyamba ndi Mlingo wocheperako, ndikuwonjezera pang'onopang'ono kuwona momwe lipoic acid amakhudzira thupi.

Ngakhale mulingo waukulu kuposa momwe analimbikitsira, mavuto sanakhazikike.

Kafukufuku wachitika ndi anthu omwe amatenga Mlingo wambiri - 2400 mg tsiku lililonse, pakatha miyezi 6 ya 1800mg-2400mg, ngakhale ali ndi Mlingo wotere, palibe zotsatira zoyipa zomwe zidapezeka.

Zitsanzo za alpha lipoic acid

Ndi mlingo wa 200-600 mg patsiku, insulin sensitivity ichulukitsa ndipo kuchuluka kwa shuga m'magazi kumachepa. Mlingo womwe uli pansi pa 200 mg sutulutsa zotsatira zowoneka bwino kuposa katundu wa antioxidant. Mlingo wa 1200 mg - 2000 mg uthandizira kuchepa kwamafuta.

Ndikwabwino kugawanitsa mankhwalawo kangapo ndikuwamwa masana. Mwachitsanzo, ngati mumatenga 1000 mg patsiku, ndiye:

• 300 mg mphindi 30 asanadye chakudya cham'mawa
• 200 mg mphindi 30 asanadye,
• 300 mg ataphunzitsidwa
• 200 mg mphindi 30 asanadye.

Momwe mungagwiritsire lipoic acid kuti muchepetse kunenepa

Alpha lipoic acid amathandiza amayi ndi amuna kuti achepetse thupi. Kafukufuku wa 2011 adapeza kuti anthu onenepa kwambiri omwe amatenga 1800 mg ya alpha lipoic acid patsiku amachepetsa kwambiri kuposa anthu omwe amagwiritsa ntchito mapiritsi a placebo. Kafukufuku wina, womwe adachitika mu 2010, adawonetsa kuti mlingo wa 800 mg tsiku lililonse kwa miyezi inayi ungayambitse kuchepa kwa 8-9% ya thupi.

Ngakhale zotsatira zabwino za kafukufuku, alpha lipoic acid si piritsi lazakudya. Mu maphunziro, alpha lipoic acid wagwiritsidwa ntchito ngati chowonjezera pophatikiza ndi zakudya zama calorie ochepa. Kuphatikizidwa ndi zakudya zopatsa thanzi komanso kuchita masewera olimbitsa thupi pafupipafupi, thioctic acid imakuthandizani kuti muchepetse kunenepa kwambiri kuposa zopanda zowonjezera.

Momwe mungagwiritsire lipoic acid kuti muchepetse kunenepa. Kusankha koyenera kungakhale kukaonana ndi dotolo kapena kukaonana ndi dokotala. Adzakhazikitsa pafupifupi kuchuluka kwa mankhwalawa tsiku lililonse, omwe angathandize kuchepetsa thupi. Mlingo umatengera magawo anu - kulemera kwake komanso thanzi lanu. Thupi lathanzi silimafunikira kuposa 50 mg ya mankhwala. Chochepera chotsika kwambiri ndi 25 mg.

Nthawi yogwira mankhwala ochepetsa thupi poyerekeza ndi ndemanga:

• Tengani lipoic acid wochepetsa thupi musanadye chakudya cham'mawa kapena mutangomaliza kudya,
• Pambuyo pochita masewera olimbitsa thupi, i.e. nditaphunzitsidwa,
• Pa chakudya chomaliza.

Kuti muwonjezere mphamvu ya zowonjezerazo, dziwani pang'ono pompopompo: ndibwino kuphatikiza kudya kwa lipoic acid kuti muchepetse thupi komanso kuyamwa kwa chakudya chamafuta. Awa ndi madeti, pasitala, mpunga, semolina kapena phala la buckwheat, uchi, mkate, nyemba, nandolo ndi zinthu zina zamafuta.

Kwa akazi, lipoic acid yochepetsa thupi imakonda kuphatikizidwa ndi levocarnitine, yomwe imawonetsedwa mu malangizo ogwiritsira ntchito ngati L-carnitine kapena carnitine wokha. Ichi ndi amino acid pafupi ndi mavitamini B, ntchito yayikulu yomwe ndi kukhazikitsa mafuta kagayidwe. Carnitine imathandiza thupi kugwiritsa ntchito mphamvu zamafuta mwachangu, limachotsa m'maselo. Pogula mankhwala ochepetsa thupi, samalani ndi mawonekedwe. Zakudya zowonjezera zambiri zimakhala ndi carnitine ndi alpha lipoic acid, yomwe ndi yabwino kwa iwo omwe akuchepetsa. Popeza pamenepa simungaganizire kuti ndi liti ndipo ndi ziti mwa zinthuzi zomwe zili bwino kutenga.

Kutenga thioctic acid kumapangitsa kuti thupi lathu lizitha kugwira bwino ntchito komanso kukhala ndi mphamvu. Zimathandizira kusintha zakudya zamagetsi kukhala mphamvu. Kuti muwonjezere metabolism yanu ndikuwotcha mafuta ochulukirapo, ndikulimbikitsidwa kutenga 300 mg ya lipoic acid tsiku lililonse.

Ntchito khungu la nkhope

Mphamvu ya antioxidant komanso anti-yotupa ya alpha lipoic acid imagwira ntchito zodabwitsa zikafika pochepetsa zizindikiro zowoneka za ukalamba. Lipoic acid ndiwothandiza komanso wodabwitsa antioxidant ndipo ali ndi mphamvu nthawi 400 kuposa mavitamini C ndi E. Mukamagwiritsidwa ntchito kunja, alpha lipoic acid imakhala yopindulitsa pakhungu - imachepetsa puffiness ndi mabwalo amdima pansi pa maso, kutupa ndi nkhope. Popita nthawi, khungu limawoneka bwino, ndikuwonjezera kupanga kwa nitric oxide, ma pores amachepetsedwa, makwinya amakhala osawonekera kwenikweni.

Zitha kukhala chifukwa cha matenda ambiri. Zina mwa izo ndizowopsa pamkhalidwe waumoyo wa anthu ndi moyo, chifukwa chiwalo ichi sichimangotulutsa bile, chofunikira pakugaya chakudya, komanso fayilo yachilengedwe ya thupi lathu yomwe imatsuka magazi pazinthu zovulaza pogwiritsa ntchito zinthu zazipanga zomwe zimapangidwira, zomwe zimakhudzidwa kagayidwe.

Pakadali pano, mankhwala sangamupatse wodwalayo mankhwala ndi njira zomwe zingapangitse kuti pakhale zopanda chiwalo chofunikira.Ngakhale kupatsirana kwa chiwindi kapena kuchotsedwa kwake pang'ono kumabweretsa zovuta zambiri, zoperewera komanso kufunikira kochita maphunziro ovuta aumoyo kwa wodwala.

Munkhaniyi, tikufotokozerani za zazikulu za zovuta za chiwindi ndi mankhwala monga lipoic (kapena thioctic) acid. Zimatha kukhala ndi chothandiza pakugwira ntchito yofunikira pa chiwalo chofunikirachi matenda monga hepatitis ndi hepatoses.

Ndi zizindikiro ziti zomwe zikuwonetsa mavuto a chiwindi?

Matenda a chiwindi amatha kuwonekera ndi zizindikiro zosiyanasiyana. Nthawi zambiri izi ndi:

• utoto wa bulauni thupi ngati mawanga,
• fungo loipa la pakhungu
• rosacea
• mpweya wabwino
• kupweteka kapena kulemera mu hypochondrium yoyenera.

Kodi lipoic acid imakhudza bwanji chiwindi?

Lipoic acid adayamba kupatulidwa yisiti ndi chiwindi mu 1948. Kuphatikizika kwake kunachitika mu 1952, ndipo zitatha izi, maphunziro adayamba pazokhudza izi m'magazi a shuga. Zotsatira zake, mu 1977, asayansi adapeza kuti lipoic acid imatha kukhala ndi zotsatira zabwino osati pancreas, komanso chiwindi.

M'matenda akuluakulu a chiwindi, anthu nthawi zonse amavutika ndi zovuta za mayendedwe omasuka pamatupi awo. Kuti zisasokoneze, ma antioxidants amafunikira, omwe amafunikira kuti azilowetsedwa m'thupi. Chimodzi mwazinthu izi ndi lipoic acid - coenzyme ya michere ina yomwe imayendetsa mafuta ndi metabolism ya carbohydrate.

Kupereka lipotropic zotsatira, antioxidant iyi imaletsa kudzikundika kwamphamvu kwamafuta m'maselo a chiwindi ndi kuchepa kwawo kwamafuta. Izi zimatheka chifukwa chakuti lipoic acid imatha kuchepetsa kumwa kwa intrahepatic antioxidant monga glutathione.

Kodi lipoic acid amalowa bwanji mthupi lathu?

Thupi laumwini palokha limatulutsa lipoic acid pang'ono. Kwenikweni, amalowa ndi chakudya.

Lipoic acid amapezeka muzinthu zotsatirazi:

• mkaka watsopano - 500-1300 mcg,
• ma mpunga - 220 mcg,
• chiwindi cha ng'ombe - ma 700 mg ma mailogalamu ochepa,
• offal - 1 chikwi, mcg,
• sipinachi amadyera - 100 mcg,
• ng'ombe - 725 mcg,
• kabichi yoyera - 150 mcg.

Zochepa, antioxidant iyi imapezekanso mu zakudya zina:

Nthawi zambiri, tsiku ndi tsiku mlingo wa antioxidant wa anthu athanzi ndi 10-50 mg. Ndi matenda a chiwindi, ayenera kukhala osachepera 75 mg, ndipo odwala matenda ashuga - 200-600 mg. Ndi kuchuluka kosakwanira kwa vitamini-ngati ichi, chiwindi chimakhala ndi mafuta ochulukirapo, ndipo mkhalidwe wotere ungayambitse kukula kapena kufalikira kwa matenda. Mutha kubwezeretsanso zosunga za antioxidant iyi mwa kuwona malamulo a zakudya zabwino kapena mwa kumwa mankhwala okhala ndi lipoic acid.

About mankhwala a lepic acid

Mankhwala a Lipoic acid ndi mankhwala okhala ndi metabolic omwe ali ofanana ndi mavitamini a gulu B.

Zizindikiro zogwiritsidwa ntchito

Mlingo wa ana ndi akulu

• Ana a zaka zopitilira 6 - 12-24 mg katatu patsiku,
• akuluakulu - 50 mg 3-4 pa tsiku.

Mankhwala ayenera kumwedwa pambuyo chakudya. Njira yovomerezeka ndi masiku 20-30. Ngati ndi kotheka, dokotala angalimbikitse kubwereza pambuyo pa mwezi. Odwala omwe amamwa mankhwalawa amalangizidwa kuti aziwonetsetsa kuti ali ndi shuga.

Zotsatira zoyipa ndi zizindikiro za bongo

Nthawi zina, kumwa Lipoic acid kumabweretsa mawonekedwe osayenera awa:

• kutsitsa shuga
• matenda am'mimba (, kupweteka kwam'mimba,),
• thupi lawo siligwirizana (zotheka kapena zamachitidwe zimachitika).

Ndi mankhwala osokoneza bongo a Lipoic acid, zizindikiro za kupweteka kwa mucous membrane am'mimba, zomwe zimafotokozedwa m'mimba ndi kusanza, zitha kuoneka.Amatha kutha kwakanthawi kochepa kwa mankhwalawo ndikutsatira mosamalitsa ku mlingo womwe adokotala akuwonetsa.

Kuyanjana kotheka ndi mankhwala ena

• imayambitsa zotsatira za insulin kapena mankhwala a hypoglycemic pakuyambitsa pakamwa,
• zimatayika pakaphatikizidwa ndi Mowa,
• Imafooketsa zochita za chisplatin,
• zimatha kusokoneza kuyamwa mwachizolowezi kwa chitsulo, magnesium ndi calcium zomwe zili m'makonzedwe (ndi kugwiritsidwa ntchito molumikizana ndi mankhwalawa, nthawi yapakati pakati Mlingo wa mankhwala uyenera kukhala osachepera maola 2).

Contraindication

• Nthawi yamimba
• Nthawi yonyamula mkaka
• ana osakwana zaka 6
• zilonda zam'mimba komanso (ndi acidity yowonjezera yam'mimba),
• kusalolera payekha.

Kutulutsa Fomu

Mankhwala a Lipoic acid amatha kupezeka m'masitolo amitundu iyi:

• mapiritsi okhala ndi chipolopolo cha 12 kapena 25 mg (10, 50 kapena 100 phukusi lililonse),
• 2% yankho mu ma ampoules a zidutswa 10 pa paketi iliyonse.

Lipoic acid analogues ndi mankhwala otere:

• Tiogamma
• Mbale 300,
• Tikiti
• Protogen
• Tiolepta
• Thioctacid BV

Dokotala uti kuti mulumikizane

Kuti mudziwe ngati wodwala akufunika kudya lipoic acid, muyenera kufunsa dokotala. ngati matendawa adziwika kale, kuyezetsa kwa gastroenterologist kapena hepatologist kuyenera. Anthu odwala matenda a shuga ayenera kudziwa za mankhwalawa kuchokera kwa endocrinologist. Kufunsa katswiri wamitsempha kumathandizanso, chifukwa lipoic acid imakhala ndi phindu pamapangidwe amanjenje.

Lipoic acid (LC) ndi mankhwala omwe kugwiritsidwa ntchito kwake kungathandize kuteteza kagayidwe. Mankhwala omwe amapanga mankhwalawa amakhudzidwa ndi kayendedwe ka lipid ndi carbohydrate metabolism, amatha kusintha kuchuluka kwa cholesterol m'magazi.

Mankhwalawa ali ndi hepatoprotective ndi detoxification, amateteza chiwindi ku zovuta zomwe zimawononga. Chifukwa chake amalembera atherosulinosis, matenda osiyanasiyana a chiwindi ndi mowa kapena matenda ashuga a shuga.

Chithandizo chophatikizika cha mankhwalawa ndi thiolic acid (Thioctic acid), chomwe ndi pawiri chomwe chimapereka chothandizidwa ndi mankhwalawa.

Lipoic acid akupezeka mu mawonekedwe a mapiritsi, makapisozi ndi njira yothetsera jakisoni.

Ndi m'gulu la antioxidant, hepatoprotective, hypolipidemic, hypocholesterolemic detoxification agents. Amapangidwa m'thupi lathu mokwanira mokwanira, koma ngati amkati thiocolic acid samakwanira, amafunika kuperekedwa kuchokera kunja.

Chidacho ndi coenzyme ya oxidative decarboxylation ya pyruvic acid ndi ketoacids, imathandizira thanzi la neurons. Izi zimachepetsa shuga m'magazi ndipo zimawonjezera glycogen m'magazi. Kuphatikiza apo, LA ikuwonetsa ntchito yapamwamba ya antioxidant.

Malangizo ogwiritsira ntchito mankhwalawa akuwonetsa kuti kuyamwa kwa thiolic acid kumayamwa nthawi yomweyo. Hafu ya moyo wa mankhwalawa ndi pafupifupi mphindi 15 pambuyo pake zomwe zimakwaniritsidwa ndi impso mu mawonekedwe a metabolites.

Lipoic acid imatha kuthandizidwa kupewetsa komanso monga gawo la zovuta mankhwala.

Lipoic acid amalembera odwala matenda ashuga ndi mowa wambiri, kuti athetse vuto la kuchepa kwa magazi, chifukwa cha hepatitis ndi cirrhosis, chifukwa cha zakumwa zochokera kumiyendo yosiyanasiyana komanso poizoni amchere wambiri.

Lipoic acid amalembedwa pakamwa monga mapiritsi komanso makolo mwa njira yothetsera kulowetsedwa.

Lipoic acid imayendetsedwa pamitsempha 300-600 mg patsiku, pafupifupi 1-2 ampoules a 10 ml + 1 ampoule 20 ml ya 3% yankho. Kutalika kwa mankhwalawa ndi milungu 2-4. Pambuyo pake, chithandizo chowongolera momwe mukumwa mapiritsi a LA akupitilizidwa. Mlingo wa tsiku ndi tsiku wokonza mankhwala ndi 300-600 mg patsiku.

Lipoic acid m'mapiritsi amatengedwa mphindi 30 asanadye, kumeza popanda kutafuna ndikutsukidwa ndi madzi pang'ono. 300-600 mg kapena piritsi limodzi limatengedwa kamodzi patsiku. Mulingo woyenera kwambiri womwe umapanga njira yoyenera yothandizira ndi 600 mg patsiku, mlingo ukatha kutha.

Zochizira matenda a chiwindi ndi kuledzera, mapiritsi 25 mg kapena 12 mg amagwiritsidwa ntchito. Amameza. Kwa akulu, mlingo ndi 50 mg mpaka 4 pa tsiku. Ana opitirira zaka 6 amatha kumwa nawo mpaka katatu patsiku. Ndipo zina mpaka mwezi. Ngati ndi kotheka, mankhwalawa amabwerezedwa pambuyo pa mwezi umodzi.

Zochizira zakumwa zoledzeretsa ndi matenda ashuga, mapiritsi a 200, 300 ndi 600 mg amagwiritsidwa ntchito. Amameza kwathunthu pamimba yopanda kanthu, otsukidwa ndi madzi. theka la ola musanadye kadzutsa, mpaka 600 mg patsiku. Chithandizo chimayamba ndi makulidwe a makolo.

Zizindikiro za bongo ndi mseru, mutu, kusanza, kutsekula m'mimba, ndi kupweteka kwam'mimba. Thupi lawo siligwirizana angayambe: urticaria, zotupa pakhungu, kuyabwa, ndipo ngakhale anaphylactic mantha. Kugwiritsa ntchito kwambiri mankhwala a lipoic acid kumatha kuyambitsa hypoglycemia. Mankhwala osokoneza bongo ndi chizindikiro.

Ndi kukhudzika kwamphamvu kwa thupi kwa mankhwalawa, mavuto amawonedwa. Mwachitsanzo, ndi jakisoni wothamanga kwambiri wa mankhwalawa m'mitsempha, kumva kuwawa m'mutu, kuvuta kupuma, komanso kupanikizika kwamphamvu kwa intracranial kumatha kuchitika.

Woopsa milandu, pambuyo mankhwala kukonzekera, kupweteka, kawiri masomphenya, kukha mwazi, thrombophlebitis, spontaneous magazi amatha kuchitika.

Kuchuluka kwa maselo olandila cell kwa lipoic acid kumatha kupangitsa kukula kwa hypoglycemia, chifukwa chomwe mlingo wa mankhwalawa umayenera kuchepetsedwa.

Munthawi ya kumwa mankhwalawa, ndikofunikira kuchepetsa kumwa, popeza mowa wa ethyl umalepheretsa kugwiritsa ntchito zinthu zochizira.

Odwala omwe ali ndi matenda ashuga ayenera kuyang'ana shuga wawo wamagazi pafupipafupi. Popeza munthawi yomweyo makonzedwe a lipoic acid ndi mankhwala a hypoglycemic amatha kupweteketsa kwambiri milingo ya shuga.

Lipoic acid amathandizidwa ndi minyewa ya mchere: 300-600 mg ya mankhwala pa 50-250 ml ya saline.

Mothandizidwa ndi intramuscularly, mlingo womwe umayikidwa jakisoni suyenera kupitirira 50 mg, womwe ndi wofanana ndi 2 ml ya yankho.

Kukonzekera kwa Thiocolic kumafooketsa mphamvu ya mankhwala a cytotoxic (mwachitsanzo, chisplatin), kotero kugwiritsa ntchito kwawo palimodzi ndizosatheka.

LC imathandizira mphamvu ya mankhwala a hypoglycemic, kotero kugwiritsidwa ntchito kwawo kuyenera kuchitika moyang'aniridwa.

LA ndi dzuwa zimapangira zovuta kusungunuka kwambiri. Chifukwa chake, kukonzekera kwa thiocolic acid sikungaphatikizidwe ndi fructose, glucose, yankho la Ringer ndi zinthu zina zomwe zimachitika ndi magulu a SH-gulu kapena kuwononga milatho.

Chifukwa chake tidauza kuti mankhwala a lipoic acid ndi ati, malangizo, magwiritsidwe, kuchuluka, mulingo, zomwe tatsala pang'ono kuiwala.

1) Thioctacid 600,
2) ,
3) Tialepta,
4) Berlition 300,
5) Thiogamma,
6) Espa-lipon.

Kuphatikizika kwa mankhwalawa kumaphatikizaponso thiolic acid, chifukwa chake onse ali ndi machitidwe ofanana omwe ali ndi LA. Kumbukirani kuti musanagule mankhwala aliwonse m'malo mwa LK, muyenera kufunsa dokotala. Kumbukirani kuti lipoic acid yokha, kugwiritsa ntchito mawonekedwe ake, imafunikira kukambirana ndi dokotala ndikuzindikira malangizo omwe amagwiritsidwa ntchito, omwe nthawi zonse amakhala m'bokosi ndi mankhwala.

Julia Ermolenko, www.site
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Alfa Lipoic Acid Slimming

Mlingo watsiku ndi tsiku umasiyana 25 mg mpaka 200 mg, kutengera kuchuluka kwa kulemera kwakukulu. Ndikulimbikitsidwa kuti muigawe mgawo 3 - musanadye chakudya cham'mawa, mutangotha ​​kuchita masewera olimbitsa thupi komanso musanadye chakudya chomaliza. Kupititsa patsogolo mafuta omwe amawotcha, mankhwalawa amayenera kudyedwa ndi zakudya za zakudya - zipatso, mpunga, semolina kapena buckwheat.

Mukamagwiritsa ntchito kuchepa kwa thupi, makonzedwe munthawi yomweyo omwe mumamwa mankhwala a l-carnitine amalimbikitsidwa. Kuti akwaniritse kwambiri, wodwalayo ayenera kuchita masewera olimbitsa thupi pafupipafupi. Kukula kwamafuta kwamankhwala kumapangidwanso ndi mavitamini a B.

Mtengo wa mankhwala a alpha lipoic acid, mawonekedwe, mawonekedwe omasulira ndi ma CD

Kukonzekera kwa Alpha lipoic acid :

• Amapezeka m'mapiritsi a 12, 60, 250, 300 ndi 600 mg, 30 kapena 60 makapisozi pa paketi iliyonse. Mtengo: kuchokera 202 UAH / 610 rub makapisozi 30 a 60 mg.

• Chogwira ntchito : thioctic acid.
• Zowonjezera zina : lactose monohydrate, magnesium stearate, croscarmellose sodium, wowuma, sodium lauryl sulfate, silicon dioxide.

Mankhwala

Imawonetsa katundu wa antioxidant, imatha kuthana ndi mavitamini C ndi E ndikuwateteza ku kuwonongeka msanga. Imalowa m'maselo onse ndi malo a interellular. Imawonjezera metabolic rate, ikuthandizira kupanga mphamvu ndi kuchira kwamthupi pambuyo pamavuto komanso katundu wolemera.

Imawonetsa zinthu zotsutsa-kutupa, kugwira ziwalo zamkati ndi pakhungu. Zimalepheretsa mapangidwe a cytokines - oyimira pakati otupa omwe amawononga khungu ndikubweretsa kukalamba msanga. Zimateteza ma hepatocytes ndipo amathandizira poizoni mu mitundu yonse ya poyizoni.

Imakhazikika pakusinthana kwa shuga m'maselo, ndikuilepheretsa kuti iphatikizane ndi mapuloteni apakhungu. Chifukwa cha izi, zimalepheretsa mapangidwe a makwinya ndikuyamba kuyambiranso kuyambira kollagen. Imabwezeretsa chinyezi chokhazikika kuti chiume khungu.

Amawongolera kusinthana kwa cholesterol ndi chakudya chamafuta, kuchepetsa kukhathamiritsa kwamafuta m'mitsempha yamafungo. Amasintha magazi kupita ku minyewa ya m'mitsempha ndi kutsitsa kwa zokakamira. Amapereka mphamvu yokwanira ya glucose yopangidwa ndi minyewa yam'mimba ndipo imawonjezera kuchuluka kwa maselo olemera kwambiri.

Bongo

Kutengera mlingo womwe watenga, zotsatirazi zitha kuonedwa. :

• Kusanza ndi kusanza.
• Mutu.
• Psychomotor mukubwadamuka ndi kusokonezeka kwa chikumbumtima.
• Zingwe.
• Kutsika kwamwazi wamagazi.
• DIC syndrome.
• Kuperewera kwa ziwalo zofunika.

Pankhani ya kumwa mankhwala opitirira 50 mg pa kilogalamu imodzi ya kulemera kwake, mankhwala oletsa kuperekera mankhwala ndi ofunikira nthawi yomweyo amafunika kuchipatala. Ndi mankhwala osokoneza bongo pang'ono, ndikokwanira kusiya kumwa mankhwalawa ndikumatsuka m'mimba ndi madzi ambiri.

Alpha Lipoic Acid Zizindikiro

Kulandila kukuwonetsedwa ku :

• Matenda a shuga ndi mowa.
• Poizoni wamphamvu komanso woopsa.
• Hepatitis ndi matenda amitsempha.
• Kupewa komanso kuchiza matenda a atherosulinosis.
• Allergodermatosis, psoriasis, chikanga, khungu louma ndi makwinya.
• Pores zazikulu ndi zipsera za ziphuphu.
• Khungu lowonda.
• Kuchepetsa mphamvu kagayidwe chifukwa hypotension ndi magazi m'thupi.
• Kunenepa kwambiri.
• Kupanikizika kwambiri.

Malangizo apadera

Osavomerezeka poyamwitsa. Pa nthawi yomwe mayi ali ndi pakati, kugwiritsa ntchito mankhwalawa kumaloledwa ngati chithandizocho chikuyembekezeka kupitilira chiwopsezo cha mayi ndi mwana wosabadwayo. Odwala omwe ali ndi matenda ashuga ayenera kuyang'aniridwa ndi shuga.

Panthawi yamankhwala, kumwa mowa kumaletsedwa kotheratu. Izi zimatha kuyambitsa kukula kwa mitsempha. Gwiritsani ntchito mosamala odwala omwe ali ndi galactose tsankho ndi kuperewera kwa lactase. Palibe umboni wonena za kuchepa kwa nthawi yamomwe mukuwongolera njira zowopsa.

Kuchita

Ndi munthawi yomweyo limodzi ndi mankhwala ena, alpha lipoic acid:

• Imafooketsa mphamvu ya chisplatin.
• Amamangirira chitsulo ndi magnesium, kotero kumwa mankhwala potengera iwo kuyenera kusamutsidwa kumadzulo.
• Imawonjezera ntchito ya insulin ndi mankhwala osakhala a mahomoni kuchepetsa shuga. Ndi njira yofewa ya matenda a shuga, nthawi zina pamakhala kufunikira kuthetsa othandizira a hypoglycemic.

Malangizo a Alpha lipoic acid

Odwala omwe amamwa mankhwalawo amayambira kusintha kwa zoonekera pambuyo pomaliza maphunziro. Imathandiza kwambiri polimbana ndi matenda ashuga a m'mimba ndi matenda amkhungu omwe amagwirizana ndi ma pathologies a collagen. Zotsatira zabwino zakukhazikitsa shuga m'magazi odwala matenda ashuga atchulidwanso zambiri.

Mosasamala za zomwe zimayambitsa matenda, odwala ambiri adanenanso kusintha kwawumoyo, kuwonjezereka kowonekera, komanso kusintha kwa mtima. Pambuyo pa kutenga alpha-lipoic acid, angapo omwe amafunsidwa omwe ali ndi ziwonetsero za chiwindi adawonetsa kutulutsa mphamvu.

Mitundu ya kumasulidwa ndi kapangidwe ka mankhwala

Lipoic acid amapangidwa mwanjira ya mapiritsi achikasu-obiriwira kapena achikasu. Piritsi imodzi yokutidwa imaphatikizapo:

• lipoic acid 0,012 kapena 0,025 g,
• talcum ufa
• stearic acid
• calcium owawa
• kukhuthala
• shuga
• shuga.

Chipolopolocho ndi:

• sera
• titanium dioxide
• magnesium yoyambira kaboni,
• aerosil
• mafuta odzola,
• polyvinylpyrrolidone,
• talcum ufa
• shuga
• utoto wachikasu.

Kuyika - makatoni makatoni momwe muli mapiritsi 10, 20, 30, 40 kapena 50, osindikizidwa ndi matuza a zidutswa 10.

Komanso, mankhwalawa amapangidwa mwanjira yothetsera jakisoni. 1 ml ya mankhwala opangira jakisoni muli:

• asidi wa lipoic - 5 mg,
• ethylenediamine
• sodium kolorayidi
• mchere wa disodium
• madzi a jakisoni.

Pakatoni kadongosolo mumakhala ma 10 ampoules a 1 ml.

Malangizo ogwiritsira ntchito ndi mlingo

Mapiritsi amatengedwa pakamwa mutatha kudya, osafuna kutafuna, ndimadzi pang'ono.

Mlingo wovomerezeka kwa munthu yemwe alibe matenda oopsa ndi 0.05 g katatu pa tsiku. Kwa matenda a chiwindi, muyezo umodzi wa 0,075 g umasonyezedwa, ndipo kwa odwala omwe ali ndi matenda ashuga, tsiku lililonse mlingo sayenera kupitirira 0,6 g.

Mankhwalawa amadziwikanso kwa ana osaposa zaka 6 muyezo wa 0.012-0.025 g katatu patsiku.

Odwala omwe ali ndi matenda a shuga, akamamwa mankhwalawa, amayenera kuwunika kuchuluka kwa shuga m'magazi am'magazi. Mankhwala osokoneza bongo ikuchitika osaposa mwezi umodzi. Ngati ndi kotheka, chithandizo chimabwerezedwa pakatha milungu iwiri.

Lipoic acid wa jekeseni amagwiritsidwa ntchito intramuscularly mu kuchuluka kwa 2-4 ml ya yankho la 0,5% (0.01-0.02 g) kamodzi. Mitsempha, mankhwalawa amaperekedwa pang'onopang'ono pa 0.3-0.6 g patsiku.

Panthawi ya chithandizo ndi mankhwalawa, ndikofunikira kusiya kumwa mowa.

Analog, wopanga

Thiolipon, Biosynthesis771 Tiolepta, CanonfarmaKusiyana: kapangidwe, wopanga, mtengo1069 Espa Lipon, EsparmaKusiyana: kapangidwe, wopanga, mtengo765 Berlition, Berlin-ChemieKusiyana: kapangidwe, wopanga, mtengo757 Thioctacid, Meda PharmaKusiyana: kapangidwe, wopanga, mtengo1574 Toigamm, Verwag PharmaKusiyana: kapangidwe, wopanga, mtengo239 Okolipen, PharmastandartKusiyana: kapangidwe, wopanga, mtengo423 Thioctic acid - 0,012 g, mapiritsi 50, BiotekKusiyana: Wopanga39

Analogue wotsika mtengo wa mankhwalawa ndi thioctic acid, yemwe ali ndi mawonekedwe omwewo ndi zotsatira zake.