Dioxidine - malangizo ntchito

Pharmacological zochita ndi yotakata sipekitiramu antibacterial (bactericidal).

Yogwira:

• Proteus vulgaris.
• Pseudomonas aeruginosa.
• Zidutswa za Friedlander.
• Escherichia coli.
• Shigella kamwazi.
• Shigella flexneri.
• Shigella boydii.
• Shigella sonnei.
• Salmonella spp.
• Staphylococcus spp.
• Streptococcus spp.
• Pathogenic anaerobes (Clostridium perfringens).

Imagwira pamagulu a mabakiteriya omwe amalimbana ndi mankhwala ena opha tizilombo, kuphatikizapo maantibayotiki. Zilibe chilichonse chakhumudwitsa kwanuko. Mwina chitukuko cha mankhwala kukana mabakiteriya.

Ndi pa / kumayambiriro kumadziwika ndi kutalika kwazithandizo, mogwirizana ndi momwe kutsatira kwambiri Mlingo wofunikira ndikofunikira.

Chithandizo cha kupsa ndi mabala a purulent-necrotic amalimbikitsa kuyeretsa mwachangu kwa bala, kumathandizanso kubwezeretsanso komanso kupweteka kwa m'mbuyo, komanso zimakhudza njira yomwe mabala amathandizira.

M'maphunziro oyesera, kupezeka kwa teratogenic, embryotoxic ndi mutagenic zotsatira zikuwonetsedwa.

Pharmacokinetics

Pambuyo pa kayendetsedwe ka iv, njira yochizira yamagazi m'magazi imakhalabe kwa maola 4-6. Nthawi yofika C _max m'magazi - patatha maola 1-2 jekeseni imodzi. Amalowa bwino komanso mwachangu ziwalo zonse ndi minyewa, yowonetsedwa ndi impso. Ndi kubayidwa mobwerezabwereza sikumachitika.

• Zizindikiro zogwiritsidwa ntchito
  • Za utsogoleri wa iv
    • Zochitika za Septic (kuphatikizapo odwala omwe ali ndi matenda oyaka).
    • Menonitis ya purulent.
    • Njira zoyipa-zotupa za m'mimba zomwe zimakhala ndi zotupa.
  • Zokhudza makina okhudzidwa
    • Njira zoyipa m'chifuwa ndi m'mimba, kuphatikizapo:
      • Purothing wokondweretsa.
      • Empyema wa kuchonderera.
      • Peritonitis
    • Cystitis.
    • Empyema wa ndulu.
    • Kupewa matenda opatsirana pambuyo catheterization wa chikhodzodzo.
  • Za ntchito zakunja, zakomweko
    • Zonda ndikuwotcha matenda:
      • Zapamwamba komanso zowawa za puroma zamitundu yambiri.
      • Zilonda zazitali zosachiritsa ndi zilonda zam'mimba.
      • Phlegmon wa zimakhala zofewa.
      • Matenda oyaka.
      • Mabala a purulent okhala ndi osteomyelitis.
    • Mabala okhala ndi mitsuko yakuzama ya purulent:
      • Chotupa.
      • Zotupa zofewa.
      • Phlegmon wa pelvic fiber.
      • Mabala a postoperative a kwamikodzo ndi biliary.
      • Purulent mastitis.
    • Matenda a pakhungu.

• Mlingo ndi makonzedwe
  • Iv Drip

    Mu zovuta kwambiri za septic, yankho la 0,5% la jakisoni limaperekedwa, lomwe limapukusidwa kale mu 5% dextrose solution kapena 0.9% sodium chloride solution yokhala ndi 0.1-0.2%. Mlingo umodzi wokhazikika kwambiri ndi 300 mg, tsiku lililonse - 600 mg.

    IV dioxidine imayendetsedwa ndi kulowetsedwa pang'onopang'ono moyang'aniridwa ndi dokotala. I / O jekeseni saloledwa.

    Ndikofunikira kuchita mayeso ololera. Pakalibe HP mkati mwa maola 3-6, mankhwalawa amayambitsidwa, apo ayi mankhwalawa sagwiritsidwa ntchito. Pofuna kupewa kutengera mawu oyamba, tikulimbikitsidwa kugwiritsa ntchito antihistamines.

  Zachinsinsi

  M'matumbo, yankho limaphatikizidwa kudzera mu chubu lamadzi, catheter kapena syringe, 10-50 ml ya yankho la 1%.

  Kunja

  Napkins yothira ndi 1% yankho tsiku lililonse kapena tsiku lililonse limayikidwa pakhungu, lomwe limatsukidwa kale ndi zotupa za purulent-necrotic, kutengera momwe mabala akuwotcha komanso njira yovulala. Zilonda zakuya zimapindika kapena kuthiriridwa ndi 0,5% yankho. Mulingo wambiri watsiku lililonse ndi 2.5 g. Kutalika kwa mankhwalawa mpaka milungu itatu.

• Contraindication
  • Momwe thupi limasokoneza.
  • Adrenal cortex kusakwanira.
  • Mimba
  • Kuyamwitsa.
  • Zaka za ana.
  
  
  • Muyenera kukumbukira kuchepa kwokhudzana ndi zaka mu ntchito ya impso mwa okalamba, zomwe zingafune kuchepa kwa mlingo wa mankhwalawa.
  • Osagwiritsa ntchito ngati pali mbiri yakusowa kwa adrenal. Ngati mankhwala ali ndi vuto la adrenal cortical kusowa, dioxidine iyenera kuthetsedwa mwachangu ndi kupatsidwa mankhwala ena.

• Mimba komanso kuyamwa

  Dioxidine amadziwikiridwa ndi pakati. Kugwiritsa ntchito yoyamwitsa kumatheka pokhapokha ngati mwana wasinthira kudyetsa thupi chabe.

Zotsatira zoyipa
Kuchokera m'mimba thirakiti

Kupweteka kwam'mimba, nseru, kusanza, kutsekula m'mimba.

Kuchokera ku dongosolo lamanjenje

Mutu, kugwedezeka kwamphamvu kwa minofu ya ng'ombe.

Zochita I / O

Chill, fever, hyperemia pamalo a jakisoni.

Thupi lawo siligwirizana

Rash, urticaria, anaphylactic mantha.

Kuchokera pa adrenal cortex

Ndi mankhwala osokoneza bongo, dystrophy, chiwonongeko, kukula kwa kusakwanira kwa adrenal kuthekera ndikotheka.

Njira zopewera kupewa ngozi

Mankhwala amadziwika ndi kupendekera kwachithandizo, motero, ndikofunikira kuyang'anira mosamala Mlingo, popewa kupitilira. M'maphunziro oyesera, adawonetsedwa kuti dioxidin ili ndi mutagenic, teratogenic, embryotoxic komanso zowonongeka pa adrenal cortex.

The poizoni zimatha dioxidine kudziwa zoletsa zake ntchito kuchipatala.

Ndi kulephera kwa aimpso komanso kukalamba, mlingo umachepa. Perekani pokhapokha ngati pali kugwiritsa ntchito mankhwala ena oyambitsa matenda.

Zambiri

Kwa zaka zopitilira 30, antibacterial agwiritsidwa ntchito bwino muzipatala zaku Russia dioxidine.

Kwa zaka zopitilira 15, zambiri kuchokera pazoyesedwa ndi mayesero azachipatala pa dioxidine asonkhanitsidwa. Mankhwala ali ndi antimicrobial kwambiri, zotsatira zingapo (makamaka pankhani ya anaerobes), imathandizira pochiza njira zoperewera za matenda opatsirana. Komabe, mankhwalawa ndi oopsa, omwe amalepheretsa kugwiritsidwa ntchito kwake ngati mankhwala othandizira. Pamabungwe azachipatala ndi pamisonkhano, ali ndi malingaliro osiyanasiyana pa dioxidine. Imawerengedwa ngati mankhwala ofunikira kwambiri komanso ofunikira pamsika wamankhwala ku Russia Federation, komabe akatswiri ambiri amalankhula molakwika za dioxidine, zomwe zimawonetsa kusakhazikika kwake komanso kukula kwakanthawi kothandizirana.

Poganizira kusiyanasiyana kwakukulu ndikukula msanga kwa mankhwala a chemotherapeutic, maubwino ndi zovuta zake, komanso kukula kwa dioxidine, ziyenera kufotokozedwa.
Ubwino ndi kuipa kwa mankhwalawa zimadalira kapangidwe kake, mawonekedwe amthupi ndi zamankhwala osiyanasiyana. Dioxidine ndi wochokera ku quinoxaline di-N-oxide. Zotuluka zoterezi zimakhala ndi antibacterial. Amadziwika ndi kuwonjezereka kwa katundu, komanso kulowa mosavuta pazomwe zimachitika. Makhalidwewa ndi omwe amawonetsera ma antibacterial zochita ndi zinthu zina zingapo zamitundu mitundu zomwe zaphatikizidwazo, kuphatikiza kawopsedwe. Derivatives ya quinoxaline di-N-oxide akhala akuphunzira mwachangu kuyambira 60-80s ya XX century. M'mayiko a Azungu, mankhwala angapo adapangidwa potengera mankhwalawa omwe ali ndi zochita zambiri za antibacterial komanso kuchuluka kwa bactericidal kanthu (quindoxin, temadox, etc.). Mankhwalawa adapeza ntchito yokhudza Chowona Chowona Chinyama - mankhwalawa komanso kupewa matenda a Salmonella ndi ma bacteria ena opha tizilombo.

Dioxidin adapangidwa ku All-Union Chemical and Pharmaceutical Research Institute ku Moscow, potengera kuwunika kwa zinthu zachilengedwe zomwe zaposa mazana awiri azinthu zino. Kuphatikiza apo, mankhwala enanso adapezeka - quinoxidine, omwe tanthauzo lake ndi mlingo wa dioxidine wogwiritsa ntchito pakamwa, chifukwa Chofunikira chachikulu cha quinoxidine ndi dioxidine. Dioxidine amapangidwa ku Russian Federation kokha.

Zomwe zimapangidwira dioxidine ngati mankhwala anali kuchuluka kwachemotherapeutic yake, yomwe imadziwika pamayesero azachipatala pazomwe zimayambitsa matenda opatsirana ofanana ndi pathogenesis ku matenda ena opatsirana a anthu (purulent meningitis, pyelonephritis, etc.) komanso chifukwa cha kukana kwa aerobic tizilombo (kuphatikizapo Pseudomonas aeruginosa) ndodo ndi Staphylococcus aureus). Kugwiritsa ntchito mankhwala motsutsana anaerobes Komanso kutsimikiza kufunika kwa mankhwalawa. Kafukufuku wasonyeza mitundu yambiri ya mabakiteriya omwe amapezeka ndi mankhwalawo. Kuchita bwino kwambiri kwa mankhwalawa kumachitika pakuwonongeka kwa mabakiteriya a anaerobic omwe amathandizira ku diatomic oxygen (kuvomerezera anaerobes). Dioxidine imathandizanso pakuwonongeka kwa aerobic tizilombo - tizilombo toyambitsa matenda opatsirana, komanso mankhwalawa matenda ena oyambitsidwa ndi mabakiteriya ofunikira (salmonellosis, shigellosis, kolera, pseudotuberculosis). Poyeserera mabakiteriya aerobic, dioxidine inali yothandiza kwambiri kupha mabakiteriya osavomerezeka: Nisseria meningitidis, Salmonella, Shigella, cholerae wa Vibrio, E. Coli, Klebsiella. Pseudomonas aeruginosa, staphylococci ndi streptococci apeza kukana kwambiri kwa mankhwalawo. Komanso, mankhwalawa amagwira ntchito molimbana ndi bacillus wa Koch (bakiteriya yemwe amayambitsa chifuwa chachikulu).


Mankhwala

Dioxidine ndi mankhwala opanga a bactericidal antimicrobial omwe ali ndi zotsatira zosiyanasiyana. Ntchito zochizira matenda opatsirana otupa. Amagwiritsidwa ntchito kunja, mwachinsinsi komanso kudzera m'mitsempha. Njira yothetsera dioxidine imakhala ndi mtundu wachikasu, kununkhira kowawa, ndipo kununkhira.

Dioxidine ndi mankhwala osokoneza bongo. Mosankha amalepheretsa mapangidwe a DNA mu khungu la microorganism, osakhudza mapangidwe a RNA ndi mapuloteni. Zimayambitsa kuphwanya kwamapangidwe amtundu wa cell ndi nucleotide ya microorganism, timalepheretsa zochita za bakiteriya nuclease ndi poizoni. Kugwiritsa ntchito bwino kwa mankhwalawa kumawonjezera pakusowa kwa mpweya chifukwa cha kukondoweza kwa kumasulidwa kwa mitundu ya okosijeni yomwe imatha. Magwiridwe a zochita za mankhwala akadali osawululidwa konse.

Kuwonjezeka kwa ntchito pansi pa anaerobiosis ndizofanana ndi zonse zamtundu wa quinoxaline di-N-oxide wokhala ndi antibacterial katundu, osawonedwa m'magulu ena a antibacterial agents. Uku ndiye kusiyana kwakukulu pakati pa pharmacokinetics of dioxidine ndi pharmacokinetics a antibacterial agents ena. M'malo a anaerobic, kuphatikiza Ndipo m'thupi lomwe muli kachilombo, dioxidine imalimbikitsa mapangidwe a ma free radicals, makamaka mitundu ya oxygen. Njira imeneyi imakhala maziko a mitundu yambiri ya mankhwala, kuphatikizapo antibacterial zochita.

Kafukufuku wokhudzana ndi ntchito ya dioxidine pakuyesedwa kwazinyama kwawonetsa kuti mankhwalawa samabisalira metabolites. Dioxidine mwachindunji amawonetsa zochita za antibacterial. Mumkodzo wa nyama zomwe zimayesa kuyeserera, chinthu chimodzi chokha cha dioxidine metabolism chinapezeka, chomwe chinalibe antibacterial. Ma metabolites onse otheka a dioxidine, omwe nawonso sanawonetse mankhwala othandizira, adadzipatula mwapadera ndikuyesedwa kuti agwire antimicrobial.

Mankhwalawa amalowera mu ubongo chotchinga magazi, kulowa muubongo. Njira yothetsera kapena mafuta a dioxidine amadzipaka bwino kuchokera pachilonda (chomwe chiyenera kukumbukiridwa ndi kugwiritsa ntchito mankhwalawa kunja). Amapukusidwa makamaka kudzera mu kwamikodzo. Pambuyo kulowetsedwa kwa mtsempha, amapezeka mkodzo kwa nthawi yayitali. Ndi infusions mobwerezabwereza, samadziunjikira m'thupi.

Makina ochita dioxidine akapakidwa mu mitundu yosiyanasiyana yoyesera amaloleza kukhala ngati gulu la chemotherapy.

Kutsutsa kwapakati pa dioxidine ndi ma bactericidal othandizira sikunawonedwe. Komabe, mwayi wokhala ndi kukana kwa tizilombo tating'onoting'ono tamankhwala samatsutsidwa.

Dioxidine samayambitsa kukwiya kwanuko. Pochiza zilonda komanso kuthandizira mabala, mankhwalawa amatsuka bwino chilonda ndikuthandizira kukonza minofu.


Amagwiritsidwa ntchito pochiza kutupa ndi kupititsa patsogolo kuthekera kosiyanasiyana.
Dioxidine amagwiritsidwa ntchito ngati mankhwala achilendo (kudzera m'mitsempha) ndi kusagwira ntchito kwa ma antimicrobial othandizira ena. Amagwiritsidwa ntchito pochiza matenda oopsa a bakiteriya omwe amayamba chifukwa cha tizilombo tating'onoting'ono ta mankhwala ena a antibacterial. Kuchiza kumachitika kokha kuchipatala, moyang'aniridwa ndi dokotala. Popeza mankhwalawa ndi oopsa, kuyezetsa mokhazikika ndi kuyesa kwa zizindikiro zofunika ndikofunikira.

Intravenous management dioxidine akuwonetsedwa motere:


• sepsis (kuphatikizapo kuyaka),
• meningitis ya purulent, kudzikundikira kwa mafinya mu ubongo,
• kufalitsa njira za zotupa
• kupewa matenda opaleshoni ya mtima (mtima ma prosthetics, corteryary artery bypass grafting).

Dioxidin imagwiritsidwa ntchito kunja ndi vnutripolost mwa njira yothetsera kapena mafuta ophikira njira yopatsirana ndi matenda opatsirana. Amagwiritsidwa ntchito mwachangu pochita opaleshoni, urology ndi mano. Mwina kuyambitsa yankho mu bronchi.

Ntchito Intracavitary Dicosidine akuwonetsedwa motere:


• puroma wokondweretsedwa,
• chibayo,
• kutupa kwa peritoneum,
• kuchuluka kwa ndulu,
• purulent cystitis,
• mabala okhudzidwa kwambiri: kupakidwa minofu yofewa, mabala opaleshoni, makanda oyeretsa, etc.,
• kupewa matenda pambuyo catheterization wa urethra.

Dioxidine ntchito kunja pa zinthu zotsatirazi:

• mabala osachepera,
• kachilombo koyaka pamalo
• Zilonda zam'mimba zonyansa.
• mabala otupa ndi osteomyelitis,
• pustular khungu pathologies.

Mlingo ndi makonzedwe

Dioxidine ukhoza kugwiritsidwa ntchito ndi akuluakulu okha.

Mitsempha (dontho)
Dioxidine amaperekedwa kudzera mu minyewa yoyang'aniridwa ndi adokotala. Kupanga mankhwala popanda dontho ndi zotsutsana. Asanalowe kulowetsedwa kuyenera kuyesedwa kulolerana. Mu sepsis yoopsa, yankho la 0.5% limathiridwa, ndikusakaniza ndi shuga ya 5% kapena ndi mchere wa 0,9% wa sodium mchere wambiri wa dicosidine wa 0.1-0.2%. Mulingo waukulu wa mankhwalawa ndi 0,3 g, mlingo waukulu wa tsiku ndi tsiku ndi 0,6 g.

Intracavitary, intrabronchial
M`kati, njira yothira mankhwala imatsanuliridwa ndi kukhetsa, catheter kapena syringe - 0,01-0.05 l ya yankho limodzi. Mulingo waukulu wa mankhwalawa ndi 0,5 g, mlingo waukulu wa tsiku ndi tsiku ndi 0,7 g.

Kunja
Pamwamba pa bala lomwe limatsukidwa ndi mafinya ndi minofu yakufa, ma tampon amakonzedwa, amawawiritsa mu gawo limodzi la yankho la mankhwalawa. Masamba amasinthidwa tsiku ndi tsiku kapena tsiku lililonse, kutengera mtundu wa mawonekedwe owonongeka ndi kuchira kwake. Mabala akuya amathandizidwa ndi yankho la 0,5% la mankhwalawa. Ndi chithandizo chanthawi yayitali ya mabala, mayankho a dioxidine a 0.1-0.2% amagwiritsidwa ntchito. Mulingo woyenera wa mankhwalawa ndi 2.5 g. Kutalika kwa maphunzirowa sikupitilira masiku 20.
Mafutawo amawaika pachingwe owonda mwachindunji pamwamba pa bala kapena kuwotcha, komwe kumatsukidwa kale ndi mafinya ndi minofu yakufa. Mu purulent patsekeke kuyambitsa tampons yothira mafuta. Pa chovala chimodzi, mpaka 30 g ya mafuta ofunikira ndi yofunikira. Zovala zamafuta zimasinthidwa tsiku ndi tsiku kapena tsiku lililonse, kutengera momwe mawonekedwe owonongeka ndi kuchuluka kwa machiritso. Mafuta okwanira omwe amagwiritsidwa ntchito patsiku ndi 0,1 kg. Kutalika kwa maphunzirowa kumatsimikizika ndi kuwopsa kwa matendawa, kuthandizira kwa mankhwalawa komanso kulolerana kwa mankhwalawa. Ndi kulekerera kwabwinobwino, chithandizo chimatenga masiku 15-25. Ngati ndi kotheka, patatha masiku 30-45, mutha kubwereza maphunzirowa.

Mu yankho la dioxidine, makhiristo amatha kuundana ndi kutentha kwa madigiri 15.Musanagwiritse ntchito yankho lake, makhiristo ayenera kusungunuka potenthetsedwa ndi madzi osamba.


Contraindication ndi zoyipa

Dioxidine amatsutsana mu:


• kusalolera pakumwa mankhwala,
• kuphwanya adrenal ntchito,
• Mimba ndi kuyamwa
• osakwana zaka 12.

Ngakhale zili zodziwikiratu zomwe mankhwalawa amapangira mankhwalawa purapy-microbial pathologies, kuwopsa kwa dioxidine adazindikira kuti ndi mankhwala osungika, makamaka ndi kulowetsedwa kwamitsempha.

Mankhwalawa ali ndi mutagenic zotsatira (amasintha kapangidwe ka cell DNA). Mutagenicity imagwira mabakiteriya komanso ma cell amunthu, ndipo zimatengera mlingo. Kulumikizana kumawonedwa pakati pa mutagenicity wa dioxidine ndi zomwe zimapangitsa kuti pakhale kupanga ma free radicals. Mu maphunziro apadera, zidatsimikiziridwa kuti mankhwala omwe amatchinga ma free radicals ndi ma antimutagen (mwachitsanzo Metaprot) amathetsa mphamvu ya mutagenic ya mankhwala. Institute of Medical Genetics yachita kafukufuku wosonyeza kuti akagwiritsidwa ntchito kwakanthawi kochepa, dioxidine samachulukitsa kuchuluka kwa maselo am'magazi.

Chifukwa cha zoyeserera za nyama, vuto lalikulu la mankhwalawo lidawululidwa - kuwonongeka kwa ma gren adrenal. Zotsatira za kuyesaku zidatsimikiza kupyola kwachilendo kwa dioxidine. Mankhwala akaperekedwa kuti ayesere nyama zochuluka maulendo 10 kuposa momwe anthu amapangira, kukula kwa adrenal cortical dystrophy kunawonedwa. Ndi kuwonjezeka kwa mulingo kapena kulowetsedwa mobwerezabwereza, kuwononga kwathunthu kwa maselo oyendetsera zinthu kumatheka ndipo, chifukwa chake, kuphwanya kwakukulu kwa kupanga kwa glucocorticosteroid. Zotsatira zake zimagwirizana mwachindunji ndi kuchuluka kwa mankhwala omwe amaperekedwa. Chifukwa chake, ndi mankhwala osokoneza bongo mwa anthu, zotsatira zoyipa zomwe zimakhudzana ndi kusintha kwachilengedwe pakupanga glucocorticosteroids ziyenera kuyembekezeredwa. Pankhaniyi, ndikofunikira kusiya jakisoni wa dioxidine ndikupeza maphunziro a mahomoni.

Popeza kuopsa kwa mankhwalawa, imapangidwa chifukwa cha tsankho la munthu, kufooka kwa adrenal gst, mimba ndi kuyamwa, komanso ana.

Komabe, ndizofunikira kusinkhasinkha kulekerera kwa mankhwalawa machitidwe azachipatala ndi pafupipafupi pazotsatira zake malinga ndi zotsatira za maphunziro omwe ali pamwambapa.

Mukamagwiritsa ntchito dioxidine mwatsatanetsatane (kulowetsedwa mwa mtsempha), angapo mavuto:


• dyspepsia
• zotupa
• mutu
• kuzizira
• hyperthermia
• kupweteka m'mimba
• kusanza
• kutsegula m'mimba
• chigoba minofu kukokana (nthawi zambiri ana a ng'ombe).

Pafupifupi kuwonetsedwa kwa zizindikiro zomwe zidatchulidwazi kunadalira zonse pamtengowo komanso pa kulekerera kwa mankhwala, ndikujambulidwa pafupifupi mu 8-10% ya odwala. Kutengera mlingo woyenera ndi kukhazikitsidwa kwa mankhwala pogwiritsa ntchito dontho, zotsatira zoyipa sizinakhale zambiri, kapena sizinayambike konse. Zochita zamankhwala zawonetsa kuthekera kwa kugwiritsa ntchito dioxidine mwa odwala omwe ali ndi tsankho (kuphatikizapo ziwengo) za mankhwala othandizira. Makamaka chidwi ayenera kulipira kwa olimba minofu kukokana. Zomwe zimachitika ndi pathogenesis yakukula kwa chizindikirochi sichikudziwikabe, komabe, pali mitundu yomwe kukula kwake kungakhale chifukwa cha kuwonjezeka kwa chiwongolero chaulere m'thupi la wodwalayo, kapena mphamvu ya mankhwalawa paminyewa ya adrenal. Ubwino wofunikira wa mpweya wabwino ndi kusapezeka kwa poizoni mu impso, chiwindi ndi ziwalo zomva.

Pazoyesa zonse ndi mayesero azachipatala, kulekerera kwabwino kwa dioxidine kunanenedwa ngati kumagwiritsidwa ntchito kwambiri.

Dioxidine ndiwophatikizika mwa ana. Komabe, kuyesayesa ndikudziwika kwazotsatira zamankhwala kuchitira ana mankhwala, kuphatikizapo mwa makanda ndi makanda. Nthawi zina, mankhwalawa amagwiritsidwa ntchito popanga opaleshoni mwa ana a zaka 5-7. Kuti athetse vuto la mutagenic, mankhwalawa adagwiritsidwa ntchito nthawi isanakwane komanso akhanda nthawi yomweyo ndi antimutagenic agents (Metaprot) pamatenda opatsirana omwe amayamba chifukwa cha mabakiteriya opanda gram. Amavomerezedwa kuti pakadali pano, kugwiritsa ntchito dioxidine mwa ana, makamaka ana osakhazikika ndi oyamwitsa, monga mankhwala othandizika kwa mankhwala, ndi kopanda tanthauzo. Ichi ndichifukwa chakuchepa kwakachiritso, kuchuluka kwa mankhwala osokoneza bongo kwa ana sichinapangidwepo) komanso zotsatira zoyipa m'misempha ya adrenal. Masiku ano, pali mankhwala othandizira odwala matenda opatsirana pogwiritsira ntchito mankhwala, othandizira odwala matenda oopsa komanso oyesedwa. Ndi mitundu yoopsa kwambiri ya mabala oyambitsidwa ndi kachiromboka komanso kuwotcha, ndi osteomyelitis, matenda oopsa a kwamikodzo, komanso matenda am'mimba, kugwiritsa ntchito dioxidine kumatheka pokhapokha kapena mwachinsinsi. Funso lakukhazikitsidwa kwa dioxidine liyenera kuganiziridwa pokhapokha pofunsira, ndikuzikidwa pa data kuchokera pakuwunikira kwa microbiological.

Dioxidin osavomerezeka kuti agwiritsidwe ntchito poyerekeza ndi matenda opatsirana omwe amayamba chifukwa cha tizilombo tokhala ndi matenda, makamaka salmonella ndi shigella. Pakaperekedwa pakamwa, nthawi zambiri zimayambitsa kugaya kwamatumbo, chifukwa chake, mawonekedwe a dioxidine wogwiritsidwa ntchito pakamwa sanalandire kuvomerezedwa ndi madokotala.

Ndi kulephera kwa aimpso, mlingo uyenera kuchepetsedwa. Ndikofunikira kulingalira zaka zomwe zimapangitsa, chifukwa anthu opitilira 60 amakhala ndi kuchepa kwa impso.


Ziyeso zamankhwala

Mankhwala aliwonse amafunika kuyesedwa kutengera deta kuchokera pakuyesera ndi kuthandizira pazachipatala. Izi ndizofunikira makamaka kwa mankhwala a antibacterial, chifukwa tizilombo tating'onoting'ono timakonda kutetezera iwo. Kuphatikiza apo, zotsatira za kugwiritsidwa ntchito kwa nthawi yayitali munthawi yamankhwala ena (mwachitsanzo, chloramphenicol kapena fluoroquinolones) zimawonetsa kuti zotsatira zoyipa zimapezeka pokhapokha pakugwiritsa ntchito mankhwalawa atatha mayesero azachipatala. Chifukwa chake, deta ya mayesawa iyenera kuwunikiridwa pafupipafupi, kuthandizidwanso, kuwonjezera komanso kusinthidwa.

Zovuta zamankhwala zamankhwala othandiza kwambiri kwa dioxidine zimachitika m'm zipatala 24 za mitundu yambiri. Kuyesaku kunachitika ndi ma purosesa angapo opatsirana oyambitsidwa ndi urological, opaleshoni komanso otolaryngological. Mayesowa anali okhudza odwala opitilira 6,000. Zambiri zamankhwala pazotsatira zoyeserera zimawonetsa kugwira ntchito kwa dioxidine mukamagwiritsa ntchito kunja, mkati, mkati, mkati komanso mkati. Izi zimasindikizidwa kwathunthu. Njira yogwiritsira ntchito mankhwalawa idatengera mawonekedwe a matendawa. Choyamba, mankhwalawa adawonetsedwa kwa anthu omwe ali ndi vuto lalikulu loyambitsa matenda opatsirana, ndi chitetezo chokwanira cha mankhwala a antibacterial, komanso kulowetsedwa kwa kulowerera - ndi kusakwanira kapena kusayenera kwa mankhwala othandizira.

Kugwiritsa ntchito mankhwalawa kwakanthawi ngati njira za 0,1, 0,5 ndi 1% kuyesedwa kwa odwala 1126 omwe ali ndi matenda opatsirana a kwamikodzo, mabala omwe ali ndi kachilomboka ndikuwotcha, osteomyelitis, kuchuluka kwa mapapu, komanso matenda a ziwalo za otolaryngological. Kugwiritsa ntchito kwa dioxidine kunali 75-91% ya milandu. Kuchita bwino kwambiri kunapezeka mankhwalawa amawotcha kwambiri, atseguka kwambiri ndi njira zopatsirana zotupa, zilonda zam'mimba zosachiritsa. Kuthira mankhwala mwachangu ndi kuyeretsa bala, kuyimitsa njira zopukutira ndi kuchiritsa kochiritsika, kuloledwa kupatsirana khungu. Kuchepa kwa pafupipafupi kwa zovuta za purulent ndikusinthika kwa minofu yothilitsidwa pambuyo poti mankhwalawa akunja azindikiridwa. Pochiza mabala akumenyekera, zotsatira zabwino zimatheka pogwiritsa ntchito yankho la 1% la dioxidine. Ndi chithandizo chanthawi yayitali cha mabala mwa odwala omwe ali ndi osteomyelitis, kuyeserera kwakukulu kumawonedwa ndikugwiritsa ntchito mayankho a 0.1- ndi 0,2%. Mukamagwiritsa ntchito mafuta osokoneza bongo a 5% a dioxidine, kuwongolera kwakukulu (60-79% ya odwala) kunazindikiridwa pakuchiza kwamatenda oyipa kwambiri oyambitsa matenda, kupatsirana mabala a necrotic, njira zochizira zotupa, kuphatikizapo pa nsagwada yapamwamba. Komanso, mafuta a dioxidine adawonetsa kukhathamiritsa kwakanthawi kwamankhwala omwe anali ndi mabala omwe ali ndi kachilombo koyambirira kwa gawo la bala - zotsatira zabwino za mayeso obwera ndi a morphological adadziwika mwa odwala 158. Kuyesa kwachilengedwe kwa odwala 523 omwe atentha kwambiri adawonetsa kuchira kwathunthu.

Zachilengedwe zotsatira za dioxidine zimatheka ndi kulowetsedwa kwamitsempha, zomwe zimawonetsedwa mu zovuta za purulent-matenda opatsirana ndi kusayenera kwa kugwiritsa ntchito ena antimicrobial othandizira. Infravenous infusions anali kuchita onse mu mawonekedwe a monotherapy, komanso kuphatikiza ena antimicrobial mankhwala. Ndi kulowetsedwa kamodzi, osaposa 300 mg wa mankhwalawa adaperekedwa. Kutalika kwa kulowetsedwa ndi maola 0,5-2, pafupipafupi ndi katatu patsiku. Systemic chithandizo mwa odwala 665 adawonetsa ntchito zambiri mu 80-90% ya milandu.

Chithandizo cha kwambiri purulent-bakiteriya matenda a m'mapapo, pleural patsekitala, suppurating mabala (kuphatikizapo trophic sanali kuchiritsa zilonda) ndi sepsis ndi mtsempha wa magazi, intracavitary, m`deralo ndi intrabronchial makonzedwe a dioxidine kuloledwa kupeza ochiritsira odwala 812. Mu odwala 210 omwe ali ndi kutupa kwa pleural, mankhwalawa adatsanuliridwa mwachindunji mu pleural patsekeke (atatsuka koyambirira). Ndi kuchuluka kwa mafinya mu pleural patsekeke, dioxidine adawonetsa kukwera kwambiri mu 88% ya milandu.

Local mankhwala mankhwala 26 odwala ambiri peritonitis amaloledwa kupeza achire zotsatira 23 milandu. Odwala 28 pachimake cholecystitis ndi chifuwa mankhwala opatsirana alandila intracavitary (mu ndulu) infusions wa 0,5% yankho la mankhwalawa. Mphamvu ya chithandizo idadziwika mu 100% ya odwala. Komabe, olemba kafukufukuyu amawona kugwiritsa ntchito yankho la 1% moyenera, chifukwa izi zimachepetsa kuchuluka kwa madzi obayira.

Infravenous infusions anaperekedwa kwa 134 odwala omwe ali ndi sepsis yozama, kuphatikizapo kuphatikiza ndi ma antibacterial othandizira ena. Mwa odwala 76 omwe ali ndi chithandizo chachikulu cha mankhwalawa, 47 odwala adalandira chithandizo chamankhwala. Zotsatira zoyipa zolembedwa mu 1.8% ya odwala omwe ali ndi kulowetsedwa kwa msana (chizungulire, kupweteka kwa mutu, palpitations, nseru) sizinafunikire njira iliyonse ndipo zinazimiririka atasiya ntchito.

Ndi infusions ya intrabronchial, kuthamanga kwakukulu kunawonedwa mwa odwala 35, okhutira mu 39, osafunikira mu 21. Kulowetsedwa kwa intrabronchial, makamaka kwa odwala omwe ali ndi mphumu, kuyenera kuyang'aniridwa ndi dokotala, chifukwa bronchospasm ingachitike.

The All-Russian Center for Opaleshoni yaphatikizanso luso logwiritsa ntchito mankhwalawa. Zambiri pakugwiritsa ntchito dioxidine mu 1460 odwala adasonkhanitsidwa. Dioxidine anali kugwiritsidwa ntchito popewa komanso kuchiza matenda a purulent komanso kutupa pamene amachitidwa opaleshoni yamkati, mitsempha, m'mimba, komanso kufalikira kwa impso. Zisonyezo zakugwiritsa ntchito mankhwalawa zidasonyezedwa bwino: kupatsira mabakiteriya osagwiritsa ntchito gramu, kupewa matenda opatsirana pogwiritsa ntchito ma cell a corsetary coronary artery. Olemba kafukufukuyu akuti akamagwiritsa ntchito dioxidine, chithandizo cha mankhwalawa chinawonjezeka, ndipo kuchuluka kwa zovuta komanso zowonjezera zotupa zimachepa. Odwala omwe ali ndi purulent kutupa kwa Mediastinum, dialysis idachitidwa bwino pogwiritsa ntchito yankho la dioxidine ndi nitrofural. Kulekerera kwabwino kulembedwa. Mwa odwala 1460 omwe adalandira dioxin mu mawonekedwe amtundu uliwonse, zoyipa (kupweteka mutu, nseru, kusanza, ng ombe) zidalembedwa mwa odwala 32 okha ndi kulowetsedwa kwa mankhwala: mu 7 atachitidwa opareshoni pachiwindi, 6 m'mimba. 7 - pamisempha yamtima, 7 - pamitsempha (mitsempha), 5 - pambuyo pothira impso. Pazifukwa zoyipa, mankhwala adathetsedwa. Pogwiritsa ntchito zakunja ndi kulowetsedwa mwachangu, zotsatira zoyipa sizinalembedwe. Mu lipoti la kugwiritsa ntchito mankhwalawa, mitundu yonse yamankhwala imafotokozedwa mwatsatanetsatane, kuphatikizapo kuphatikiza ndi mankhwala ena.

Institute of Neurosurgery dzina lake N.N. Burdenko alinso ndi mwayi wogwiritsa ntchito dioxidine. M'mabuku, chidwi chapadera chimaperekedwa pakugwiritsa ntchito mankhwalawa matenda opatsirana a chapakati mantha dongosolo (chidwi chimakhudzidwa ndi zomwe takumana nazo za endolumbar infusions). Sichikwiyitsa pakulowa muubongo, chomwe ndi chofunikira pothandizira matenda a purulent pathologies.

Zotsatira zakuchipatala zochizira matenda opatsirana odwala khansa zimawonetsa kugwira ntchito komanso kutha kwa ntchito kwa dioxidine.

Kuyang'aniridwa kuyenera kulipidwa kuti ntchito bwino kwa mankhwalawa mu urology. Zotsatira zabwino zidapezeka ndikugwiritsa ntchito kunja kuti tipewe matenda ndikutulutsa kwa catheter mu chikhodzodzo, komanso chithandizo cha mabala othandizira pa opaleshoni ya impso. Kuchita kumawonetsa kukhathamira kwa mankhwalawa kwa kuthilira kwa nthawi yayitali kwamankhwala othandizira ndi 0.25-1% yankho la osteomyelitis, komanso kuphatikiza magawo olimbirana ndi yankho la 1%. Zodziwika bwino ndizomwe zimachitika pamene kudula fistula yosachiritsika ndi njira ya dioxidine wodwala wokhala ndi chifuwa chachikulu kudapangitsa kuti fistula ichiritsidwe. Ntchito ya mankhwala yolimbana ndi bacillus ya Koch imafuna chisamaliro chapadera.


Pali analogue ya dioxidine - Quinoxidine, wopangidwa mwanjira ya mapiritsi ogwiritsira ntchito pakamwa pokha. Gawo logwira la quinoxidine ndi dioxidine. Mwakutero, quinoxidine ndi mtundu wa dioxidine wogwiritsa ntchito pakamwa. Kuwonongeka kwa zovuta kuchokera kugaya kwam'mimba kumakhala kwakukulu. Mankhwalawa akuwonetsedwa wamitundu ingapo yamatenda amkodzo thirakiti, komanso kwa akulu okha ndi kulekerera kwabwino. Zochita zamankhwala pochiza matenda opatsirana kwamkodzo zikuwonetsa kuti quinoxidine ilibe phindu poyerekeza ndi mankhwala amakono ambiri a antibacterial, makamaka fluoroquinolones.


Malo osungira

Tatyana, wa zaka 32, Berdyansk
Zaka ziwiri zapitazo, kumayambiriro kwa chisanu, khutu langa lidatsekedwa. Tsiku lonse kumva ngati khutu lokhazikika ndi thonje, kumverera sikosangalatsa. Izi zidatenga sabata, panalibe zizindikiritso zake. Nditatembenukira kwa otolaryngologist wanga, adapereka madontho a dioxidine. Ndidafunsa za zoyipa - adotolo adati iyi ndi mankhwala otetezeka kwathunthu, wolimbikitsidwa ngakhale kwa ana. Amayi adavomereza kusankhidwa uku, ponena kuti m'mbuyomu otitis media ankalandira mankhwala okha a ana.
Nditatsatira malingaliro ake, ndidagula mulu umodzi ndikuwakhazikitsa khutu. Pasanathe mphindi zisanu, ndinanong'oneza bondo - kuti ndimamva zowawa zambiri m'makutu mwanga, ndinangofinya maso anga, ndikuyembekezera kuti adutse. Koma ululuwu sunachepe. Patatha ola limodzi, ndidasankha kuyesa wowerengeka wowerengeka - chithandizo ndi madzi a anyezi. Mwamuna wanga adadula anyezi, ndikufinya msuziwo kuchokera pamenepo - ndidabwanyika swab thonje ndikulowetsa khutu langa (ndidanyowetsa mkati mwa tampon ndi madzi ndikusiya mbali yakunja youma chifukwa anyezi wa anyezi limakwiyitsa nembanemba ya mucous). Pakadali mphindi 15 mpaka 15 ululu utatheratu.
Nditachira ku zowawa, ndidaganiza zophunzira zambiri za dioxidine. Zidapezeka kuti mankhwalawo ndi owopsa ndipo alibe vuto lililonse. Ndipo pamabungwe azachipatala, madokotala nawonso amatsimikizira kuti dioxidine ndi mankhwala oopsa, chifukwa chake amatha kugwiritsidwa ntchito ngati chomaliza, ndipo nthawi zambiri amasemphana ndi ana.
Ndidaganiza zowunikira otolaryngologist, koma adangodabwa ndikufalitsa manja ake. Zotsatira zake, adandipangira mankhwala ena - otipax. Ndinagula botolo, ndikuliyendetsa kwa masiku 7 kapena 8, koma khutu langa silinalole. Zotsatira zake, nditakhumudwitsidwa pazokonzekera zamankhwala, ndinabwereranso ku njira yachikhalidwe ndi madzi a anyezi.
Pa tsiku loyamba la mankhwala, mafinya anayamba kuchepa, ndipo ambiri. Pambuyo pa masiku atatu, makulidwewo adachoka, ndipo pakali pano zonse zili khutu.
Umu ndi momwe ndidaphunzirira moyo wanga wonse - tsopano, choyambirira, ndimayesetsa kuthandizidwa ndi njira zachikhalidwe ndi mankhwala achilengedwe, ndipo ndimayesetsa kupewa mankhwala osagwiritsidwa mwadzidzidzi ..

Angela, wa zaka 28, Moscow
Chaka chapitacho, mwana wanga wamkazi amadwala ndi sinusitis - poyamba amafuna kudzipulumutsa, komabe anaganiza zofunsa dokotala wa ana. Dokotala wa ana adapereka mtundu wa madontho amphuno a dioxidine kapena protargol. Protargol mumzinda wathu siyidaigulitse, motero ndidapeza dioxidine ampoule. Wopukutidwa ndi madzi (50 mpaka 50) ndikuyamba kuwukitsa mwana wamkazi. Pofika nthawi imeneyi, zotulutsa m'mphuno zamkati zinali zitawonekeranso, motero ine ndi mwana wanga wamkazi timayamba kukokoloka limodzi ndi yankho. Komabe, palibe ine kapena mwana amene anasintha. Ndidaganiza zokana, ndipo ndidayamba kutsuka mphuno yanga ndimadzi amchere ine ndi mwana wanga wamkazi. Pambuyo pa njirayi, Derinat adakhazikika. Kuti tichiritse, zidatitengera masiku 5 okha.
Pambuyo pake adawerenga pa intaneti kuti dioxidine imalowetsedwa mwa ana mumtundu uliwonse, ngakhale mawonekedwe am'mphuno. Sindikumvetsa kuti mwana wathu amawongoleredwa ndi chiyani pomwe amamulembera ...

Zitsamba zomwe zimachepetsa shuga m'magazi mwachangu

• Zolinga zazikulu za mankhwala azitsamba
• Zitsamba zochepetsa shuga?
• Mankhwala a shuga
• Maphikidwe azitsamba
• Contraindication

Zitsamba zochepetsera shuga ndimagazi zimatchedwa mbewu zomwe zimatha kuthana ndi shuga wa nthawi yayitali chifukwa cha momwe zimakhudzira thupi la wodwalayo. Monga zinthu zonse zachilengedwe, zitsamba zimakhala zofewa komanso zochepa pang'onopang'ono kuposa mankhwala opangira, motero ndi bwino kuzigwiritsa ntchito nthawi yanthawi yayitali.

Zolinga zazikulu za mankhwala azitsamba

Sitinganene kuti zitsamba zochepetsera shuga zimatha kuthana ndi vuto, koma phytotherapy (mankhwala azitsamba a shuga mellitus) uyenera kutengedwa ngati njira yothandizira. Zikhala zothandiza chifukwa cha kuchuluka kwa glucose m'magazi, kugwiritsa ntchito mankhwala ovuta kukhala chinthu chovuta kwambiri paumoyo. Zotsatira zabwino zitha kuchitika ngati muphatikiza zitsamba zamafuta ndizakudya zoyenera komanso kukhala ndi moyo wathanzi, komabe ndikofunikira kuyang'ana mozama pakugwiritsa ntchito kwawo.

Zolinga zikuluzikulu za mankhwala azitsamba ziyenera kuganiziridwa kuti zipangitse magazi kukhala abwinobwino, kukonza chimbudzi, kulimbitsa chitetezo chokwanira komanso kutulutsa mawu. Kudziwa zitsamba ziti zomwe zimachepetsa shuga la magazi a anthu odwala matenda ashuga, simungathe kuthana ndi vutoli, komanso nthawi yomweyo mudzaze thupi ndi zinthu zambiri zofunikira komanso mavitamini. Musanagwiritse ntchito zitsamba zilizonse, ndikofunikira kukaonana ndi dokotala ndikuvomerezedwa, chifukwa miyambo yomwe imakhala yopindulitsa poyambira ingakhale yovulaza ngati itaperekedwa kwa wodwala payekhapayekha.

Mukamagwiritsa ntchito mankhwala osokoneza bongo osiyanasiyana, kapena kumwa mankhwala azitsamba mwanjira yawo, munthu asayiwale kuti sangathe kusintha zinthu zomwe zingafunike mthupi, chifukwa chake thanzi silikhala lopindulitsa pacakudya chokhwima cha "azitsamba".

Zitsamba zochepetsa shuga?

Zitsamba zonse za shuga zomwe zimachepetsa shuga m'magazi zitha kugawidwa m'magulu angapo kutengera mphamvu yawo yogwiritsa ntchito shuga m'thupi. Zotsatira zake ndi mndandanda wazinthu zitatu:

• zimbudzi zam'mimba
• Zitsamba zomwe zimakhudzana ndi glucose pamakomedwe a maselo,
• zitsamba zomwe zimathandizira kuchotsa shuga mthupi.

Kuzindikira kusiyana pakati pa chomera china kumathandizira kwambiri pakuthandizira kwa odwala matenda a shuga ndi zitsamba. Gawo loyamba litha kugawidwa m'magulu awiri: zitsamba zomwe zimagwira ntchito mwachangu, komanso zomwe zimayamba kugwira ntchito pakulowetsedwa kwa shuga ndi matumbo a matumbo. Ponena za njira yoyamba, mbewuzi sizikhala ndi shuga wotsika kwambiri monga magazi, chifukwa zimachepetsa kuchuluka kwa chakudya chomwe chimadyedwa pachakudya. M'malo mwake, amadzaza ndikutambasula m'mimba, zomwe zimapatsa ubongo kumva kuti mwakhuta, ndipo mbewu za fulakesi kapena zothira ndizoyenera kwambiri pankhaniyi. Supuni imodzi yophika m'madzi otentha ndikuyika kwa maola awiri ndi yokwanira, ndipo madziwo amayenera kutengedwa ola limodzi ndi theka asanadye. Bhonasi yomwe yakwaniritsidwa ikuyenera kukhala cholandirira ndi mavitamini ambiri ndi mafuta acids, zomwe zimakhudza magwiridwe antchito a maselo am'mimba ndikumayendetsa shuga ndi insulin kudzera mwa iwo.

Nawonso, ngati chakudya chamagulu am'mimba chovulaza chomwe chayambitsa matenda ashuga chalowa kale mthupi, lingaliro labwino lingakhale kuyesa kuchepetsa kuchuluka kwa mayamwidwe awo, momwe chitsamba chomwe chimachepetsa shuga m'magazi ngati Yerusalemu artichoke ndi choyenera. Mizu ya chikhalidwe ichi, ikadyedwa, imakutira makhoma am'mimba, pomwe ulusi wazomera zomwe zili momwemo zimatenga shuga wosungunuka mu madzi a m'mimba. Chimodzi mwazakudya izi ndi inulin, yomwe imawonedwa ngati yabwino kwambiri yachilengedwe, ndipo ngati mulibe Yerusalemu atitchoku, dandelions kapena burdock angachite.

Chithandizo cha matenda ashuga omwe ali ndi zitsamba ndizothekanso pamalingaliro a matenda a glucose omwe amapangidwa ndi ziwalo zomwe zimapangidwa kuti zizigwira ntchito. Zotsatira zake, kugwiritsa ntchito zitsamba pamenepa kungathe kulimbikitsa kupanga insulin mu kapamba, komanso kuthekera kwa chiwindi kugwiritsa ntchito glucose owonjezera pakusintha kwake kukhala glycogen. Kutha kugwiranso ntchito zambiri mothandizidwa ndi ginseng, ndikuchita zotsatirazi:

• kuchepa kwa ntchito ya insulin inhibitors (imathandizira kutulutsa shuga m'magazi kupita ku minofu),
• Kubwezeretsa maselo a pancreatic owonongeka, akuvutika ndi matenda osokoneza bongo chifukwa cha kuchuluka kwa insulin,
• imathandizira kaphatikizidwe ka glycogen - mawonekedwe otetezeka a chakudya omwe amatha kudzikundikira kuti adzagwiritse ntchito mtsogolomo minofu ndi minofu.

Mtundu wina wa zitsamba womwe ndi wothandiza kwa matenda amtundu wa 2 kapena mtundu wa 2 ndiwomwe umadziwika kuti vagotonics: Zomera zomwe zimaperekedwa kwa anthu omwe amakhala ndi nkhawa nthawi zonse kapena akuvutika kwambiri ndi vuto la mantha. Ndondomekozi zimatha kuwonjezera kuchuluka kwa shuga m'magazi, kuzimasulira, komanso zimakhudza ntchito ya kapamba, kotero wodwala amafunikira mbewu zotonthoza - mistletoe, sinamoni, peonies.

Mu matenda a shuga, thupi limataya zinc kwenikweni, koma chinthuchi ndichofunikira pakapangira mamolekyu a insulin omwe amapangidwa mu kapamba, komanso amathandizira kulolerana kwa mahomoni am'maselo a thupi. Chifukwa chake, ndikofunikira kuti wodwalayo aphatikizire azitsamba azitsamba okhala ndi zinc omwe ali ndi zokwanira - masamba a birch, masamba a birch, sage, ndi mbalame kumtunda. Kutenga kapu ya kulowetsedwa kotala (okonzedwa muyezo wa wina mpaka 50) musanadye chakudya chilichonse, mutha kusintha kwambiri kagayidwe ka kagayidwe kachakudya ndi shuga. Pomaliza, chinthu china chomwe chimathandizira kuti insulin ikwaniritse ntchito yake ndi chromium yomwe ili mu arnica, ginseng ndi mankhwala a mandimu. Monga momwe zilili ndi zinc, decoctions amayenera kukonzedwa kuchokera ku zitsamba izi, kuwalola kuti azilimbikira asanagwiritse ntchito.

Gulu lachitatu la zitsamba lomwe limakhudza kuchuluka kwa shuga m'magazi a shuga m'magayidwe akudya ndi mbewu zomwe zimachotsa glucose wambiri m'thupi. Izi zisanachitike, zinthu zili bwino kuti zisayende, koma ngati chakudya chamagetsi chadyedwa, ndipo mita ikuwonetsa kuchuluka, muyenera kulimbikitsa kudzipereka kwa shuga kudzera mu impso. Zomera zotsatirazi zimakhala ngati othandizira mwachilengedwe:

• masamba a birch
• akavalo
• Mbalame yayitali
• mliri
• Wort wa St.

Pharmacological mawonekedwe a mankhwala

Amaryl ndi mankhwala a hypoglycemic omwe amathandiza kuwongolera dzuwa la plasma. Yogwira pophika mankhwala ndi glimepiride. Monga omwe adatsogolera, Glibenclamide, Amaril ndiwonso wochokera ku gulu la sulfonylurea, lomwe limalimbikitsa kapangidwe ka insulin kuchokera ku maselo a b pancreatic a Langerhans.

Kuti akwaniritse zomwe akufuna, amatseka njira ya potaziyamu ya ATP ndi chidwi chochulukirapo. Sulfonylurea ikalumikizana ndi ma receptor omwe ali pamalimba a b-cell, zochitika za gawo la K-AT zimasintha. Kutsekeka kwa njira za calcium ndi kuwonjezeka kwa kuchuluka kwa ATP / ADP mu cytoplasm kumapangitsa kuti membrane awonongeke. Izi zimathandiza kumasula njira za calcium ndikuwonjezera kuchuluka kwa calcium ya cytosolic.

Zotsatira za kukopa kwachidziwikire kwa ma granules achinsinsi, komwe ndi njira yotulutsira mankhwala ophatikizira pakati pa maselo, ndikutulutsa kwa insulin m'magazi.

Glimepiride ndi woimira m'badwo wachitatu wa sulfonylureas. Zimapangitsa kuti amasulidwe mahomoni a pancreatic mwachangu, amathandizira chidwi cha insulini cha mapuloteni komanso maselo a lipid.

Tizilomboti timatulutsa michere timagulugasi timagwiritsa ntchito mapuloteni ochokera ku ma cell a cell. Ndi mtundu wodziimira payekha wa shuga, kusintha kwa shuga m'matipi kumachepetsedwa. Glimepiride imalimbikitsa kukwera kwa kuchuluka kwa mapuloteni oyendetsa ndikuwonjezera ntchito yawo. Mphamvu yamphamvu kwambiri ya kapamba imathandizira kuchepetsa kukanira kwa insulin (insensitivity) kwa mahomoni.

Amaryl imalepheretsa kuphatikizika kwa glucogen ndi chiwindi chifukwa cha kuchuluka kwa kuchuluka kwa fructose-2,6-bisphosphate ndi antiaggregant (chopinga cha kupangidwa kwa thrombus), antiatherogenic (kuchepa kwa zizindikiro za cholesterol "choyipa") komanso antioxidant (kusinthika, kuthana ndi kukalamba). Njira za oxidation zimachepetsedwa chifukwa chowonjezeka pazomwe zimakhala za end-native b-tocopherol komanso ntchito ya antioxidant enzymes.

Pharmacokinetics wa mankhwala

Popanga Amaril, gawo lalikulu lomwe limagwira ndi glimepiride kuchokera ku gulu la sulfonylurea. Povidone, lactose monohydrate, magnesium stearate, microcrystalline cellulose ndi utoto wa E172, E132 amagwiritsidwa ntchito ngati ojambula.

Amaryl imayendetsa michere ya chiwindi 100%, kotero ngakhale kugwiritsidwa ntchito kwa nthawi yayitali kwa mankhwalawa sikuwopseza kudzikundikira kwake pazinthu komanso minyewa. Zotsatira zakonzedwe, zotumphukira ziwiri za glipemiride zimapangidwa: hydroxymetabolite ndi carboxymethabolite. Metabolite yoyamba imapatsidwa mankhwala omwe amapereka chokhazikika cha hypoglycemic.

M'magazi, zomwe zimakhala pazomwe zimagwira ntchito zimawonedwa pakatha maola awiri ndi theka. Kuwona zamtundu wathunthu wa bioavailability, mankhwalawa saletsa odwala matenda ashuga posankha zakudya zomwe "agwiritse" mankhwalawo. Mafuta adzakhala mulimonse 100%.

Kuwongolera kwakukulu kwa glycemic indices kumawonedwa ngakhale ndi zovuta ndi chiwindi, makamaka, mukulira (wazaka zoposa 65) komanso ndi vuto la chiwindi, kugwiritsidwa ntchito kwa chinthucho ndi kwachibadwa.

Momwe mungagwiritsire ntchito Amaryl

Mankhwala amapangidwa mwanjira ya mapiritsi ozungulira omwe ali ndi mzere wogawa, womwe umakulolani kuti mutha kugawa mlingo mosavuta pakati. Mtundu wa mapiritsiwo umatengera mlingo: 1 mg wa glimepiride - chipolopolo, 2 mg - khungu, 3 mg - chikasu.

Kapangidwe kameneka sikanasankhidwe mwamwayi: ngati mapiritsi amatha kusiyanitsidwa ndi mtundu, izi zimachepetsa chiopsezo cha bongo mwangozi, makamaka mwa okalamba.

Mapiritsi amayikidwa m'matumba a 15 ma PC. Bokosi lililonse limatha kukhala ndi mbale ziwiri mpaka 6.

Zomwe mungagwiritse ntchito pa Amaril:

1. Piritsi (kapena gawo lake) limamezedwa lonse, kutsukidwa ndi madzi osachepera 150 ml. Mukangomwa mankhwala, muyenera kudya.
2. Endocrinologist amasankha dongosolo la mankhwalawa malinga ndi zotsatira za kusanthula kwa zinthu zachilengedwe.
3. Yambani maphunzirowa ndi ma Mlingo wocheperako wa Amaril. Ngati gawo la 1 mg patapita nthawi yochepa silikuwonetsa zotsatira zomwe zakonzedwa, mulingowo umachuluka.
4. Mlingo umasinthidwa pang'onopang'ono, mkati mwa masabata 1-2, kotero kuti thupi likhale ndi nthawi yosinthira kuzatsopano. Tsiku lililonse, mutha kuwonjezera kuchuluka kwa osaposa 1 mg. Mulingo waukulu wa mankhwalawa ndi 6 mg / tsiku. Mulingo wokhazikitsidwa ndi adokotala.
5. Ndikofunikira kukonza zomwe zimachitika ndikusintha kwa kulemera kwa odwala matenda ashuga kapena kuchuluka kwa mitsempha ya minofu, komanso kuwoneka ngati chiwopsezo cha hypoglycemia (ndi njala, kuperewera kwa zakudya m'thupi, kuledzera, mavuto a impso ndi chiwindi.
6. Nthawi yogwiritsira ntchito komanso mlingo wake zimatengera mtundu wamoyo ndi mawonekedwe a kagayidwe. Nthawi zambiri, kamodzi pamakonzedwe a Amaril amakhazikitsidwa patsiku limodzi ndi chakudya. Ngati chakudya cham'mawa chadzaza, mutha kumwa mapiritsi m'mawa, ngati chophiphiritsa - ndibwino kuphatikiza phwando ndi nkhomaliro.
7. Mankhwala osokoneza bongo amawopseza ndi hypoglycemia, pomwe shuga m'mitsempha amatsika mpaka 3.5 mol / L kapena kutsikira. Vutoli limatha kupitilira kwa nthawi yayitali: kuchokera maola 12 mpaka masiku atatu.

Mapiritsi a Amaryl (phukusi la zidutswa 30) amagulitsidwa pamtengo wa:

• 260 rub - 1 mg,
• 500 rub - 2 mg aliyense
• 770 rub. - 3 mg aliyense
• 1020 rub. - 4 mg aliyense.

Mutha kupeza mapiritsi a mapiritsi 60, 90,120.

Zina zomwe zimagwirizana ndi mankhwala

Anthu odwala matenda ashuga, makamaka "okhala ndi chidziwitso", monga lamulo, amakhala ndi zovuta zambiri zotsutsana: matenda oopsa, mtima ndi mtima, mavuto a metabolic, impso ndi chiwindi. Ndi kitiyi, simuyenera kungomwa mankhwala ochepetsa shuga.

Pofuna kupewa nthenda yamitsempha yamagazi ndi mtima, mankhwala omwe ali ndi aspirin adayikidwa. Amaryl imachotsa phula mapuloteni, koma mulingo wake m'magazi sunasinthe. Zotsatira zonse zovuta za ntchito zovuta zimatha kusintha.

Kupititsa patsogolo ntchito AMARE Kuwonjezera yake insulin, Allopurinu, coumarin ofanana nawo, anabolic mankhwala, guanethidine, chloramphenicol, fluoxetine, fenfluramine, pentoxifylline, Feniramidolu, fibric asidi ofanana nawo, phenylbutazone, miconazole, azapropazone, probenecid, quinolones, oxyphenbutazone, salicylates, tetracycline, sulfinpyrazone, Tritocqualin ndi sulfonamides.

Amaril amachepetsa kuthekera kwa kuwonjezera Epinephrine, glucocorticosteroids Diazoxide, mankhwala othandizira, Glucagon, barbiturates, Acetazolamide, saluretics, thiazide diuretics, nicotinic acid, Phenytoin, Phenothiazine, Rifampicin, Chlorpromazine, ndi progestin.

Kuphatikizidwa kwa Amaryl kuphatikiza histamine H2 receptor blockers, Reserpine ndi Clonidine kumapereka zotsatira zosayembekezereka ndi madontho a glucometer mbali iliyonse. Zotsatira zomwezi zimapereka mowa ndi Amaril.

Mankhwalawa sasokoneza ntchito ya ACE inhibitors (Ramipril) ndi anticoagulant agents (Warfarin) mwanjira iliyonse.

Kugwirizana kwa Hypoglycemic

Ngati mankhwala aliwonse a hypoglycemic afunika kulowetsedwa ndi Amaril, muyeso wocheperako (1 mg) umayikidwa, ngakhale pokhapokha wodwala atalandira chithandizo chamankhwala chachikulu.Choyamba, momwe chamoyo cha matenda ashuga chimayang'aniridwa kwa masabata awiri, kenako mlingo umasintha.

Ngati wothandizila odwala matenda ashuga omwe ali ndi theka la moyo adagwiritsidwa ntchito pamaso pa Amaril pofuna kupewa kukula kwa hypoglycemia, payenera kukhala kupuma masiku angapo atachotsedwa.

Ngati wodwalayo adatha kusunga kapamba kuti apange mahomoni ake, ndiye kuti jakisoni wa insulin akhoza 100% kulowa Amaryl. Maphunzirowa amayambanso ndi 1 mg / tsiku.

Ngati njira yachikhalidwe yolipira shuga ya Metformin siyilola kuwongolera kwathunthu matenda a shuga, mungathe kuwonjezera Amaril 1 mg. Ngati zotsatirazo sizikukwaniritsa, pang'onopang'ono zimasinthidwa mpaka 6 mg / tsiku.

Ngati chiwembu cha Amaril + Metformin sichinakwaniritse zoyembekezeredwa, chimasinthidwa ndi Insulin, ndikukhalabe chizolowezi cha Amaril. Jakisoni wa insulin amayambanso ndi mlingo wochepera. Ngati zizindikiro za glucometer sizili zolimbikitsa, onjezani kuchuluka kwa Insulin. Kugwiritsanso ntchito limodzi kwamankhwala kumakhalabe koyenera, chifukwa kumakupatsani mwayi wochepetsa mphamvu ya mahomoni ndi 40% poyerekeza ndi mahomoni oyera.

Kuphatikiza pa Amaril, endocrinologist amakhalanso ndi zosankha: Amaperid, Glemaz, Diapyrid, Diameprid, Glimepiride, Diagliside, Reclid, Amix, Glibamide, Gllepid, Glayri, Panmicron, Glibenclamide, Gligenclad, Glliblik Dimari Glimaril, Glyclazide, Manil, Maninil, Glimed, Glioral, Olior, Glynez, Glirid, Gluktam, Glypomar, Glyurenorm, Diabeteson, Diabresid.

Kwa iwo omwe adapangidwira, ndipo omwe mankhwalawo sanalimbikitsidwe

Mankhwalawa adapangira zochizira matenda a shuga a mtundu wachiwiri. Amagwiritsidwa ntchito limodzi ndi monotherapy komanso mu zovuta kuchipatala motsatana ndi Metformin kapena Insulin.

Gawo logwira ntchito la Amaril limagonjetsa chotchinga cha placenta, ndipo mankhwalawa amapatsanso mkaka wa m'mawere. Pachifukwachi, sioyenera kuti azimayi oyembekezera azikumbukira. Ngati mkazi akufuna kukhala mayi, ngakhale asanakhale ndi pakati pa mwana, ayenera kusamutsidwira ku insulin popanda Amaril. Kwa nthawi yakudyetsa, nthawi zoterezi zimasungidwa, ngati pakufunika chithandizo ndi Amaril, kuyamwitsa kuyimitsidwa.

Kugwiritsa ntchito mankhwalawa odwala matenda ashuga komanso vuto lomwe lisanafike pa chikomokere ndilosavomerezeka. M'mavuto akulu a matenda ashuga (monga ketoacidosis), Amaryl sawonjezedwa. Mankhwalawa sioyeneranso kwa odwala matenda ashuga okhala ndi mtundu woyamba wa matenda.

Ndi magwiridwe antchito a impso ndi chiwindi, Amaryl siothandiza, Amaril sakutchulidwa hem hemalalitis ndi matenda ashuga, komanso payekha tsankho la glipemiride kapena mankhwala ena a sulfonamide ndi gulu la sulfonylurea.

Ndi matumbo paresis kapena m'matumbo, kutsekeka kwa mankhwalawa kumasokonezeka, kotero Amaril sanalembedwe kuti achulukitse mavuto. Amafuna kusinthana ndi insulin komanso kuvulala kambiri, maopaleshoni, matenda otentha kwambiri, komanso kuwotcha koopsa.

Pochizira mafupa, owerenga athu adagwiritsa ntchito DiabeNot bwino. Kuwona kutchuka kwa malonda, tidaganiza zoperekera chidwi chanu.


Amaril akhoza kukhala limodzi ndi hypoglycemic zimachitika. Nthawi zina odwala amadandaula chifukwa cha chizungulire, ena amafooketsa kugona, pamakhala manjenjenje, thukuta kwambiri, komanso vuto lakulankhula. Ndi matenda a shuga, nthawi zambiri mumakhala mavuto osaneneka a njala, mavuto a kuuma, kusapeza bwino mchiwindi. Kutheka kwa vuto la mtima, chotupa pakhungu. Nthawi zina magazi amatuluka.

Zotsatira za bongo

Kugwiritsa ntchito mankhwalawa kwakanthawi, komanso kumwa mopitirira muyeso, kumayambitsa hypoglycemia, zomwe zimafotokozedwa m'gawo lakale.

Wodwala matenda ashuga ayenera kukhala ndi cholembera chofotokoza bwino za matenda ake ndi china chake kuchokera ku chakudya cham'thupi (maswiti, makeke). Madzi okoma kapena tiyi ndiwofunikanso, pokhapokha popanda zotsekemera zotengera. Woopsa milandu, wodwala ayenera kuchipatala mwachangu kuti akonzenso chapamimba ndi makonzedwe a absorbents (adamulowetsa kaboni, zina ndi zina).

Zotsatira zoyipa

Nthawi zina, kugwiritsa ntchito Amaril kumayendera limodzi ndi zotsatira zoyipa mwanjira ya kutaya kwamaso, mavuto ndi njira yoyendera magazi, matenda a metabolic, matenda am'mimba.

Zina mwazambiri:

1. Glycemic syndrome, yodziwika ndi kusweka, kusokonezeka kwa chidwi, kulephera kuwona, arrhythmia, njala yosalamulirika, thukuta kwambiri.
2. Kusiyana kwazomwe zikuwonetsa shuga, zomwe zimapangitsa kuwonongeka kwa mawonekedwe.
3. Matenda a dyspeptic, kuphwanya mtundu wa defecation, ndikusowa mankhwala akachotsedwa.
4. Thupi lanu losiyanasiyana zovuta (zotupa pakhungu, kuyabwa, ming'oma, matumbo osokoneza bongo, anaphylactic kugwedezeka, kuthamanga kwa magazi komanso kufupika kwa mpweya).

Kutenga Amaril kumakhudza kuthamanga kwa ma psychomotor reaction - kuyendetsa galimoto, komanso ntchito yofunikira kuti ithe chidwi, makamaka koyambirira kwa chithandizo, sizigwirizana ndi Amaril chithandizo.

Maganizo a madokotala ndi odwala matenda ashuga okhudza Amaril



Ndemanga za endocrinologists omwe amakumana ndi mawonetseredwe a matenda obisika ndizofunikira kwambiri, chifukwa ali ndi mwayi wofufuza momwe wodwala amvera kuti apereke lingaliro pazothandiza.

Malinga ndi madotolo, ndi regimen yoyenera yopanga mankhwala, Amaril amathandizira kupangitsa kuti glycemic indices isafike mokwanira. Anthu odwala matenda ashuga omwe amamwa mankhwalawa amakhala ndi zodandaula za hypoglycemia pamene mulingo wosankhidwa bwino. Ndipo komabe, zamankhwala Amaril, ndemanga za odwala ndi zabwino.

Zakudya zama carb otsika, masewera olimbitsa thupi, kuwongolera kunenepa kwambiri. Wodwala matenda ashuga ayenera kudziwitsa endocrinologist mu nthawi yokhudza mavuto, zizindikiro za hypo- ndi hyperglycemia zomwe zimachitika ndi Amaril.

Chithandizo chimaphatikizanso kudziyang'anira pawokha mayendedwe a shuga ndikuwunika ntchito za chiwindi, mayeso a labotale, makamaka kuyesa kwa hemoglobin ya glycated, yomwe masiku ano imadziwika kuti ndiyo njira yoyesera kwambiri yotsimikizira momwe wodwala alili ndi matenda a shuga. Izi zikuthandizira kuzindikira mulingo wokana Amaril pakukonzanso njira zamankhwala.

Mutha kuphunzira za zina za Amaril kuchokera video.

Zambiri

Wothandizira mankhwala "Dimexidum" ali ndi antibacterial, analgesic komanso anti-kutupa katundu.

Shuga amachepetsedwa nthawi yomweyo! Matenda a shuga m'kupita kwa nthawi angayambitse matenda ambiri, monga mavuto amawonedwe, khungu ndi tsitsi, zilonda zam'mimba, zilonda zam'mimba komanso matenda otupa! Anthu amaphunzitsa zinzake zowawa kuti azisintha shuga. werengani.

Cholinga chake chachikulu ndikuchiza matenda a dermatological, komanso mankhwalawa adadzitsimikizira pakuchotsa kupweteka kwa minofu ndi mafupa. Ndi achire, Dimexide imaletsa chinthu chomwe chimapangidwa - dimethyl sulfoxide.

Dimexide amapangidwa m'njira zosiyanasiyana:

• gwiritsirani ntchito madzi, omwe musanagwiritse ntchito amafuna madzi,
• msuzi
• makandulo
• mafuta.

Chofunikira kwambiri pokonzekera zamankhwala chili ndi antipyretic, disinfectant, antihistamine. Imakhala ndi "Dimexide" yotchulidwa kuti thrombolytic katundu, wophatikizidwa ndi zigawo zamagazi (magazi owundana). Magawo a mankhwalawa amalowa mosavuta pakhungu ndi mucous membrane, amathandizira kutsokomola kwa dermis ndikuwongolera kupezeka kwazinthu zina zamankhwala.

Dimexide amalembedwa kuti athetse mavuto opweteka monga:

Mankhwalawa ali ndi mitundu yambiri yogwiritsira ntchito matenda a pakhungu.

kukomoka komanso kuumitsa minofu yolumikizana,

• thupi lawo siligwirizana mitsempha ya pakhungu ndi mafuta ochepa,
• zotupa za pakhungu,
• mabala oyera
• pachimake purulent-necrotic kutupa kwa follicle tsitsi,
• chikanga
• kutupa kwamkati wamkati wamkati ndikupanga kwa magazi,
• amayaka
• matenda am'mimba,
• zilonda zam'mimba
• kutukusira kwa zotupa za sebaceous.

"Dimexide" yogwira mtima komanso matenda osiyanasiyana a musculoskeletal system:

• kutupa kosagwirizana kwa mafupa
• lowetsani (kupweteka m'dera la minofu) wokhala ndi zovuta zowonongeka,
• kutupa kwa zolumikizira mafupa, zomwe zimabweretsa kuphatikizika,
• kukwapula, mikwingwirima,
• kusintha kwa kuphatikizira kwa trophic komwe kunachitika motsutsana ndi maziko a ma pathologies ena,
• kutupa kwa muzu umodzi wamitsempha ya msana.

Momwe mungagwiritsire ntchito komanso kuchuluka kwa matenda ashuga?

Odwala omwe ali ndi matenda ashuga amatha kugwiritsa ntchito bwino Dimexidum ndipo saopa kuti zingakhudze kuchuluka kwa shuga m'magazi. Monga gawo la mankhwalawa palibe zinthu zomwe zingakulitse kuchuluka kwa shuga, chifukwa chake, ndi shuga, imagwiritsidwa ntchito monga mwa chizolowezi. "Dimexide" imagwiritsidwa ntchito kunja, kuthirira mavuto ammimba kapena kugwiritsa ntchito compress yokhazikika mu yankho la iwo. Chopukutira chopukutira, chomwe chimasungunuka kale ndi yankho lamadzi mumagawo ofanana, chimayikidwa pamalo omwe akukhudzidwa. Ngati mukufuna kugwiritsa ntchito mankhwalawa kuzinthu zofunika kwambiri za thupi, ndiye kuti yankho lake limaphatikizidwa malinga ndi 1: 3, 1: 5 kapenanso 1:10. Pamwamba pa chopukutira chimakutidwa ndi nsalu ya thonje ndikukhazikika ndi bandeji kapena zomatira. Kutalika kwa njira ya achire ndi masiku 10-15.

Contraindication

Mankhwala omwe akufotokozedwayu saloledwa kwa odwala omwe ali ndi vuto lofanana ndi zigawo zake. Dimexide iyenera kusiyidwa kwa odwala omwe apezeka ndi ma pathologies otsatirawa:

Ngati kugunda kwadzidzidzi kwa mtima kukuwonekera, siyani kugwiritsa ntchito mankhwalawa.

Kuchepetsa mphamvu ya m'mitsempha yamagazi,

Tchuthi ndi malo osungira

Mutha kugula mankhwala ku pharmacy popanda mankhwala kuchokera kwa dokotala. Phukusi lamankhwala liyenera kusungidwa kutali ndi ana aang'ono. Ndikofunikira kuti mchipinda momwe mankhwalawo agonekere, kutentha sikuyenera kupitirira 25 digiri Celsius, ndipo malo omwewo atetezedwe kuti asalowe ndi kuwala kwadzuwa. Ndi yosungirako bwino, moyo wa alumali ndi zaka ziwiri.