Gliclazide (Gliclazide)

Gliclazide MV ndi wothandizira wa hypoglycemic pochiza matenda a shuga a mtundu wachiwiri. Zomwe zimagwira ndi Gliclazide.

Oral hypoglycemic wothandizira, yemwe amapezeka m'badwo wachiwiri. Imayendetsa katulutsidwe ka insulin ndi β-cell ya kapamba.

Mankhwala kumawonjezera mphamvu ya zotumphukira zimakhala insulin, kumalimbikitsa ntchito intracellular michere (makamaka, minofu glycogen synthetase). Amachepetsa nthawi kuchokera pakudya mpaka kuyamba kwa insulin. Kubwezeretsanso pachimake cha insulin katulutsidwe, kumachepetsa chiwerengero cha hyperglycemia pambuyo pake.

Gliclazide MV imachepetsa kuphatikiza kwa maselo ndi kuphatikiza, imachepetsa kukula kwa parietal thrombus, ndikuwonjezera ntchito ya mtima. Matendawa mtima kukhathamira.

• Lowers magazi cholesterol (Cs) ndi Cs-LDL
• Kuchulukitsa ndende ya HDL-C,
• Imachepetsa zopitilira muyeso.
• Zimalepheretsa kukula kwa microthrombosis ndi atherosulinosis.
• Amasintha kusintha kwakachulukidwe.
• Imachepetsa mphamvu ya mtima ku adrenaline.

Ndi matenda a shuga a nephropathy omwe amagwiritsidwa ntchito kwa nthawi yayitali, pali kuchepa kwakukulu kwa proteinuria.

Popereka mankhwala, kuwongolera kwambiri glycemic kumakhala ndi maubwino ambiri osakhazikitsidwa ndi zotsatira za mankhwala omwe ali ndi antihypertensive mankhwala.

Kapangidwe ka Gliclazide MV (piritsi limodzi):

• Zogwira ntchito: gliclazide - 30 kapena 60 mg,
• Zothandiza: hypromellose - 70 mg, colloidal silicon dioxide - 1 mg, cellcrystalline cellulose - 98 mg, magnesium stearate - 1 mg.

Zizindikiro zogwiritsidwa ntchito

Kodi chimathandiza Gliclazide MV ndi chiyani? Malinga ndi malangizo, mankhwala ochizira matenda oopsa a 2 matenda a shuga (osagwirizana ndi insulin) omwe ali ndi chiwonetsero choyambirira cha matenda a shuga a shuga.

Imagwiritsidwanso ntchito kupewetsa matenda am'mimba, monga gawo la zovuta mankhwala, munthawi yomweyo ndi zina zotumphukira za sulfonylurea.

Malangizo ntchito Gliclazide MV (30 60 mg), mlingo

Mankhwalawa amatengedwa pakamwa mphindi 30 asanadye.

Mlingo watsiku ndi tsiku wa Gliclazide MV amalimbikitsidwa ndi 80 mg ndi malangizo omwe angagwiritsidwe ntchito; ngati kuli kotheka, ukuwonjezeka mpaka 160-320 mg mu 2 mg.

Mlingo payekha kutengera kusala kudya kwa glycemia ndi 2 mawola chakudya, komanso matendawo mawonetseredwe a matendawa.

Mukaphonya mlingo, simungatenge kumwa pawiri. Mukasinthira mankhwala ena a hypoglycemic, nthawi yosinthika sifunikira - Gliclazide MB iyamba kutengedwa tsiku lotsatira.

Mwina kuphatikiza ndi Biguanides, insulin, alpha-glucosidase inhibitors. Wofatsa pang'ono komanso wolephera kulephera, imafotokozedwanso yemweyo Mlingo.

Odwala omwe ali pachiwopsezo cha hypoglycemia, mlingo wochepa umagwiritsidwa ntchito.

Malangizo apadera

Mankhwalawa osagwirizana ndi insulin omwe amadalira shuga, mankhwalawa amayenera kugwiritsidwa ntchito nthawi imodzi ndi zakudya zama calorie zochepa zomwe zimakhala ndi chakudya.

Pa mankhwala, muyenera kuyang'anira kusinthasintha kwa tsiku ndi tsiku m'magazi a glucose, komanso kuchuluka kwa shuga m'magazi pamimba yopanda kanthu ndikatha kudya.

Zotsatira zoyipa

Malangizowa amachenjeza za mwayi wokhala ndi zotsatirapo zoyipa mukamapereka Gliclazide MV:

• Kusanza, kusanza, kupweteka m'mimba,
• Supombocytopenia, erythropenia, agranulocytosis, hemolytic anemia,
• Matupi a mziwambo,
• Zotupa pakhungu, kuyabwa,
• Kulephera kwa chiwindi
• Zowonongeka
• Hypoglycemia (wokhala ndi mankhwala osokoneza bongo).

Contraindication

Glyclazide MV imaphatikizidwa mu milandu yotsatirayi:

• Mtundu woyamba wa matenda a shuga 1
• Ketoacidosis
• Matenda a shuga komanso chikomokere
• Zowopsa zaimpso ndi chiwindi.
• Hypersensitivity kuti sulfonylureas ndi sulfonamides.
• Kugwiritsa ntchito munthawi yomweyo gliclazide ndi imidazole zotumphukira (kuphatikizapo miconazole).

Amatchulidwa mosamala muukalamba, zakudya zosakhazikika, hypothyroidism, hypopituitarism, coronary artery matenda komanso atherosulinosis, adrenal insufficiency, chithandizo chazitali ndi glucocorticosteroids.

Bongo

Zizindikiro zopitirira muyeso zimawonetsedwa ndi hypoglycemia - kupweteka mutu, kutopa, kufooka kwambiri, thukuta, kukwiya, kukwiya, kusachedwa kuyankha, kusawona bwino ndi kuyankhula, kunjenjemera, chizungulire, kukhumudwa.

Ndi hypoglycemia wofatsa popanda kumva kukomoka, kuchepetsa mlingo wa mankhwalawo kapena kuwonjezera kuchuluka kwa chakudya choperekedwa ndi chakudya.

Ngati matenda a hypoglycemic coma atapezeka kapena akuganiza kuti mwina, 50 ml ya 40% ya glucose solution (dextrose) uyenera kuvulazidwa (kudzera m'mitsempha). Pambuyo pake, 5% dextrose solution imalowetsedwa kudzera m'mitsempha, yomwe imakuthandizani kuti muzikhala ndi glucose yoyenera m'magazi (pafupifupi 1 g / l).

Magazi a glucose amayenera kuyang'aniridwa mosamala ndipo wodwalayo ayenera kuyang'aniridwa mosalekeza kwa masiku osachepera awiri atapezeka kuti ali ndi bongo wambiri.

Kufunika kowunikira ntchito zofunika kwambiri za wodwala kumatsimikizidwanso ndi momwe alili.

Popeza chinthu chomwe chimagwira ntchito kwambiri chimagwirizana ndi mapuloteni a plasma, dialysis siyothandiza.

Analogs Glyclazide MV, mtengo pama pharmacies

Ngati ndi kotheka, mutha kusintha Gliclazide MV ndi analogue mu achire - awa ndi mankhwala:

Mukamasankha analogi, ndikofunikira kumvetsetsa kuti malangizo ogwiritsira ntchito Glyclazide MV, mtengo ndi kuwunika, sagwiritse ntchito mankhwala omwe ali ndi vuto lofananalo. Ndikofunikira kupeza upangiri wa dokotala komanso kuti usasinthe popanda mankhwala.

Mtengo m'masitolo a ku Russia: Mapiritsi a Glyclazide MV 30 mg 60 - kuchokera ku ruble 123 mpaka 198, mapiritsi a Glyclazide MV 60 mg 30 - kuchokera ku 151 mpaka 210 rubles, malinga ndi 471 pharmacies.

Sungani pamalo amdima, osatheka ndi ana kutentha mpaka 25 ° C. Moyo wa alumali ndi zaka zitatu.

Pharmacology

Kuchulukitsa katemera wa insulin ndi maselo a pancreatic beta ndikusintha magwiritsidwe ntchito a shuga. Imalimbikitsa ntchito ya minofu ya glycogen synthetase. Kugwiritsa kagayidwe kachakudya kagayidwe kachakudya matenda a shuga, odwala ndi exogenally kukhazikika kwa kunenepa. Mbiri ya glycemic pambuyo masiku angapo chithandizo. Imachepetsa nthawi yanthawi kuyambira pakudya mpaka pachiyambireni cha insulin, imabwezeretsa kuchuluka kwa insulin ndikumachepetsa hyperglycemia yomwe idayamba chifukwa cha kudya. Amasintha magawo a hematological, ziwopsezo zamagazi, magazi a heestasis ndi ma cellcirculation. Zimalepheretsa kukula kwa microvasculitis, kuphatikizapo kuwonongeka kwa diso la diso. Imaphatikizira kuphatikiza kwa maselo othandiza magazi kuundana, kumachulukitsa chidziwitso chogwirizana, kumawonjezera heparin ndi fibrinolytic ntchito, kumawonjezera kulolerana kwa heparin. Imawonetsa katundu wa antioxidant, imakweza conjunctival vascularization, imapereka magazi mosalekeza ma microvessels, amachotsa zizindikiro za microstasis. Ndi diabetesic nephropathy, proteinuria imachepetsedwa.

Poyeserera pa kafukufuku wamankhwala osakhazikika komanso enieni a kawopsedwe, palibe chizindikiro cha carcinogenicity, mutagenicity ndi teratogenicity (makoswe, akalulu), komanso zovuta pa chonde (makoswe) zidawululidwa.

Mokwanira komanso mwachangu odziwika bwino m'mimba, C_max zimatheka pambuyo maola 2-6 (mapiritsi okhala ndi masinthidwe osinthika - pambuyo pa maola 6-12) atatha kutsata. Mgwirizano wa plasma wofanana umapangidwa pambuyo masiku awiri. Kumangiriza kwa mapuloteni a plasma ndi 85-99%, kuchuluka kwa magawo ndi 13- 24 l. Kutalika kwa gawo limodzi ndi mlingo umodzi kumafika maola 24 (mapiritsi okhala ndi mapiritsi osinthidwa - maola opitilira 24). Mu chiwindi, imadutsa oxidation, hydroxylation, glucuronidation ndikupanga 8 osagwira metabolites, amodzi mwa omwe ali ndi tanthauzo pa microcirculation. Imafufutidwa mu mawonekedwe a metabolites ndi mkodzo (65%) komanso kudzera m'mimba yogaya (12%). T_1/2 - Maola 8-12 (mapiritsi okhala ndi masinthidwe osinthika - pafupifupi maola 16).

Zotsatira zoyipa za mankhwala Glyclazide

Kuchokera m'mimba: kawirikawiri - zizindikiro za dyspeptic (nseru, kusanza, kupweteka kwam'mimba), kawirikawiri - jaundice.

Kuchokera pamtima ndi magazi: kusintha kosinthika cytopenia, eosinophilia, kuchepa magazi.

Pa khungu: kawirikawiri - khungu lawo siligwirizana, photosensitivity.

Kuchokera kumbali ya kagayidwe: hypoglycemia.

Kuchokera wamanjenje ndi ziwalo zam'maganizo: kufooka, kupweteka mutu, chizungulire, kusintha kukoma.

Kuchita

Zotsatira kuenjezera Ace zoletsa, anabolic mankhwala, beta-blockers, fibrates, biguanides, chloramphenicol, cimetidine coumarin, fenfluramine, fluoxetine, salicylates, guanethidine, Mao zoletsa, miconazole, fluconazole, pentoxifylline, theophylline, phenylbutazone, phosphamide, tetracyclines.

Barbiturates, chlorpromazine, glucocorticoids, sympathomimetics, glucagon, saluretics, rifampicin, mahomoni a chithokomiro, mchere wa lithiamu, milingo yayikulu ya nicotinic acid, kulera kwapakamwa komanso estrogens - kufooketsa hypoglycemia.

Bongo

Zizindikiro Hypoglycemic zinthu, mpaka chikomokere, ubongo edema.

Chithandizo: kuyamwa kwa shuga mkati, ngati kuli kotheka - mu / pakubweretsa yankho la shuga (50%, 50 ml). Kuyang'anira shuga, urea nayitrogeni, ma seramu electrolyte. Ndi ubongo edema - mannitol (iv), dexamethasone.

Mosamala Glyclazide

Munthawi ya kusankha kwa mlingo, makamaka mukaphatikizidwa ndi insulin, ndikofunikira kudziwa mawonekedwe a shuga ndi mphamvu ya glycemia, mtsogolomo kuwunika kwamagazi a shuga kumasonyezedwa. Pofuna kupewa hypoglycemia, ndikofunikira kuti muzigwirizana bwino kwambiri pakudya, pewani kufa ndi njala ndikusiya kumwa mowa kwathunthu. Kugwiritsa ntchito nthawi yomweyo kwa beta-blockers kungathe kubisa zizindikiro za hypoglycemia. Zakudya zama carb otsika-pansi zimalimbikitsidwa. Gwiritsani ntchito mosamala mukamagwira ntchito yoyendetsa magalimoto ndi anthu omwe ntchito yawo imalumikizidwa ndi chidwi chochuluka.

Kutulutsa mawonekedwe ndi kapangidwe kake

Gliclazide MV imapangidwa ngati mapiritsi okhala ndi mtundu wosinthika: cylindrical, biconvex, yoyera yokhala ndi kirimu wowiritsa kapena yoyera, kuyenda pang'ono pang'ono (10, 20 kapena 30 zidutswa mu contour aluminium kapena polyvinyl chloride cell phukusi, 1, 2, 3, 4, 5, 6, 10 mapaketi okhala ndi mtolo wa makatoni, 10, 20, 30, 40, 50, 60, kapena ma PC.Matumba apulasitiki, 1 amatha mu mtolo wa makatoni).

Piritsi limodzi lili ndi:

• The yogwira mankhwala: gliclazide - 30 mg,
• Zothandiza: hypromellose - 70 mg, colloidal silicon dioxide - 1 mg, cellcrystalline cellulose - 98 mg, magnesium stearate - 1 mg.

Mankhwala

Glyclazide ndi sulfonylurea yotengedwa yomwe imakhala ndi hypoglycemic katundu ndipo imapangidwira pakamwa. Kusiyana kwake ndi mankhwala omwe ali mgululi ndi kukhalapo kwa mphete ya heterocyclic ya N yokhala ndi chomangira cha endocyclic.

Gliclazide amachepetsa shuga wamagazi, pokhala othandizira pakupanga insulin ndi maselo a beta a isanger a Langerhans. Kuchuluka kwa C-peptide ndi insulin ya postprandial imapitirira pambuyo pa zaka 2 za chithandizo. Monga momwe zimakhalira ndi zinthu zina za sulfonylurea, izi zimachitika chifukwa cha zomwe β-cell za zisumbu za Langerhans zimayambitsa kukoka kwa glucose, zomwe zimachitika molingana ndi mtundu wa thupi. Gliclazide samangoyendetsa kagayidwe kazakudya, komanso zimakhumudwitsa zotsatira za hemovascular.

Odwala omwe ali ndi mtundu wachiwiri wa matenda a shuga, gliclazide imathandizira kubwezeretsa kupanga kwa insulini koyambirira, zomwe zimachitika chifukwa cha kuchuluka kwa shuga komanso zimapangitsa gawo lachiwiri la insulin kutulutsa. Kuwonjezeka kwakukulu kwa kaphatikizidwe ka insulin kumayenderana ndi kuyankha komwe kumayambitsidwa ndi shuga kapena kudya.

Kugwiritsidwa ntchito kwa gliclazide kumachepetsa chiopsezo chokhala ndi chotupa cham'magazi a m'magazi mwakuchita zinthu zomwe zingapangitse kukula kwa zovuta kwa odwala omwe ali ndi matenda osokoneza bongo, kuchepa kwa zomwe zili m'maselo a cell plation (thromboxane B₂, beta-thromboglobulin), kupewera pang'ono kwa kupatsidwa zinthu za m'magazi komanso kuphatikiza, komanso kukhudza kubwezeretsanso kwa ntchito ya fibrinolytic ya vascular endothelium, ndikuwonjezera ntchito ya plasminogen, yomwe imathandizira minofu.

Kugwiritsa ntchito glycazide yosinthidwa, glycosylated hemoglobin (HbAlc) yomwe ikutsikira ndi yochepera 6.5%, chifukwa cholamulira kwambiri glycemic molingana ndi mayeso odalirika azachipatala, ingachepetse chiopsezo cha zovuta zazikuluzikulu za mtundu waukulu wa 2 poyerekeza ndi glycemic yachikhalidwe ulamuliro.

Kukhazikitsa kwa glycemic kwambiri kumakhala ndi mankhwala a gliclazide (pafupifupi tsiku ndi tsiku ndi 103 mg) ndikuwonjezera mlingo wake (mpaka 120 mg patsiku) mukamalandira mankhwala ena kumbuyo (kapena m'malo mwake) musanawonjezere ndi mankhwala ena a hypoglycemic (mwachitsanzo, insulin, metformin thiazolidinedione derivative, alpha glucosidase inhibitor). Kugwiritsa ntchito gliclazide pagulu la odwala omwe akuwongolera kwambiri glycemic (pafupifupi, mtengo wa HbAlc anali 6.5% ndipo nthawi yayitali yowunikira inali zaka 4.8), poyerekeza ndi gulu la odwala omwe akuyang'aniridwa muyezo (kuchuluka kwa HbAlc kunali 7.3% ,, adatsimikiza kuti chiwopsezo chopezeka pafupipafupi cha macro- cell ndi macrovascular chimachepetsedwa kwambiri (10%) chifukwa cha kuchepa kwakukulu pachiwopsezo chokhala ndimavuto akulu (14%), nthawi Itijah ndi Kukula kwa microalbuminuria (9%), zosokonezeka aimpso (11%), isanayambike ndi Kukula kwa nephropathy (21%), ndi chitukuko cha macroalbuminuria (30%).

Mukamapereka mankhwala a gliclazide, kuwongolera kwambiri glycemic kumakhala ndi maubwino ambiri osakhazikitsidwa ndi zotsatira za mankhwala omwe ali ndi antihypertensive mankhwala.

Pharmacokinetics

Pambuyo pakukonzekera pakamwa, glycoside imalowa mu gawo logaya chakudya ndi 100%. Zomwe zili m'madzi a m'magazi zimachulukana pang'onopang'ono kuposa maola 6 oyambirira, ndipo ndendeyo imakhala yokhazikika kwa maola 6-12. Kuchuluka kwa mayamwidwe a gliclazide palokha popanda chakudya.

Pafupifupi 95% yazinthu zonse zomwe zimagwira ntchito zimagwirira kumapuloteni a plasma. Kuchuluka kwa magawo ndi pafupifupi malita 30. Kulandila kwa Gliclazide MV mu mulingo wa 60 mg kamodzi patsiku kumakupatsani kukhalabe achire ambiri a gliclazide mu madzi am'magazi kwa maola 24 kapena kuposerapo.

Gliclazide metabolism imachitika makamaka m'chiwindi. Ma metabolacologic omwe amagwira ntchito mu plasma sanatsimikizike. Gliclazide imatheka makamaka kudzera mu impso mu mawonekedwe a metabolites, pafupifupi 1% imachotsedwa mu mkodzo. Hafu yapakati ya moyo ndi maola 16 (chizindikirocho chimatha kusiyana ndi maola 12 mpaka 20).

Chiyanjano chotsogola chinajambulidwa pakati pa mankhwala ovomerezeka (osapitirira 120 mg) ndi malo omwe ali pansi pa pharmacokinetic curve "nthawi -". Odwala okalamba, palibe kusintha kwakukuru kwamapiritsi a pharmacokinetic.

Contraindication

• Mtundu woyamba wa matenda a shuga 1
• Matenda akulu a chiwindi ndi impso,
• Ketoacidosis
• Matenda a shuga ndiodwala
• Ntchito zogwirizana ndi imidazole zotumphukira (kuphatikizapo miconazole),
• Hypersensitivity kuti sulfonamides ndi sulfonylureas.

Kugwiritsidwa ntchito kwa Glyclazide MV sikulimbikitsidwa kuti azimayi anyama ndi apakati.

Malangizo ogwiritsira ntchito Gliclazide MV: njira ndi mlingo

Gliclazide MV imatengedwa pakamwa asanadye.

Kuchulukana kwa mankhwalawa ndi 2 kawiri pa tsiku.

Dokotala amadziwitsa tsiku lililonse mlingo uliwonse, kutengera mawonekedwe ake a matendawa ndi glycemia, pamimba yopanda kanthu komanso maola awiri atatha kudya.

Monga lamulo, mlingo woyambirira ndi 80 mg patsiku, avareji yapakati ndi 160-320 mg patsiku.

Malangizo apadera

Pochiza matenda osokoneza bongo omwe amadalira shuga, Gliclazide MV iyenera kugwiritsidwa ntchito nthawi yomweyo ndi zakudya zama calorie zochepa zomwe zimakhala ndi chakudya.

Pa mankhwala, muyenera kuyang'anira kusinthasintha kwa tsiku ndi tsiku m'magazi a glucose, komanso kuchuluka kwa shuga m'magazi pamimba yopanda kanthu ndikatha kudya.

Ndi chithandizo cha opaleshoni kapena kuwonongeka kwa matenda a shuga, kutha kugwiritsa ntchito mankhwala a insulin kuyenera kuganiziridwanso.

Pankhani ya hypoglycemia, ngati wodwalayo akudziwa, shuga (kapena shuga) ayenera kugwiritsidwa ntchito pakamwa. Zikatayika, glucose (intravenously) kapena glucagon (subcutaneously, intramuscularly kapena intravenally) amayenera kuperekedwa. Pofuna kupewa kukonzanso kwa hypoglycemia pambuyo pobwezeretsa chikumbumtima, wodwalayo ayenera kupatsidwa chakudya chopatsa thanzi.

Kugwiritsa ntchito nthawi yomweyo gliclazide ndi cimetidine osavomerezeka.

Ndi kuphatikiza kwa gliclazide ndi verapamil, ndikofunikira kuyang'anitsitsa kuchuluka kwa shuga m'magazi, ndi acarbose, kuyang'anira mosamala ndi kuwongolera kwa kuchuluka kwa mankhwalawa a hypoglycemic othandizira ndikofunikira.

Kukopa pa kuthekera koyendetsa magalimoto ndi njira zowerengeka

Odwala omwe akutenga Glyclazide MV ayenera kudziwa za zomwe zingachitike mu hypoglycemia ndikuwachenjeza za kufunika kosamala mukamayendetsa kapena kuchita ntchito zina zomwe zimafuna kuti ma psychomotor ayambe kusintha, makamaka kumayambiriro kwa chithandizo.

Mimba komanso kuyamwa

Palibe zokuchitikirani ndi kuikidwa kwa Gliclazide MV kwa amayi apakati. Kafukufuku wazinyama sanatsimikizire kupezeka kwa zotsatira za teratogenic pazinthu izi. Ndi chiphuphu chosakwanira cha matenda a shuga mellitus panthawi ya chithandizo, pali chiwopsezo chowonjezereka cha kubereka kosabereka mu fetus, komwe kumatha kuchepetsedwa ndikuwongolera koyenera kwa glycemic. M'malo mwa gliclazide mwa amayi apakati, tikulimbikitsidwa kugwiritsa ntchito insulin, yemwenso ndi mankhwala osankhidwa kwa odwala omwe akukonzekera kutenga pakati, kapena iwo omwe ali ndi pakati panthawi yochizidwa ndi Gliclazide MV.

Popeza palibe chidziwitso pakudya kwa yogwira pophika mu mkaka wa m'mawere, ndipo mwa akhanda kumene pamakhala chiwopsezo chokhala ndi neonatal hypoglycemia, kutenga Gliclazide MB pa mkaka wa m`mawere amatsutsana.

Kuyanjana kwa mankhwala osokoneza bongo

Ndi kuphatikiza kwa Gliclazide MV ndi mankhwala ena osokoneza bongo, zotsatirapo zosavomerezeka zingachitike:

• Pyrazolone derivatives, salicylates, phenylbutazone, antibacterial sulfonamides, theophylline, caffeine, monoamine oxidase inhibitors (MAOs): kuthekera kwa hypoglycemic zotsatira za glyclazide,
• Osasankha beta-blockers: kuchuluka kwa hypoglycemia, kuchuluka thukuta ndi chigoba cha tachycardia ndi kugwedezeka kwa manja kodziwika kwa hypoglycemia,
• Gliclazide ndi acarbose: kuchuluka kwa hypoglycemic,
• Cimetidine: kuchuluka plasma gliclazide ndende (kwambiri hypoglycemia ingayambike, kuwonetseredwa mu mawonekedwe a kupsinjika kwa chapakati mantha dongosolo komanso kusokonezeka chikumbumtima),
• Glucocorticosteroids (kuphatikizapo mitundu yakunja ya mankhwala), okodzetsa, barbiturates, estrogens, progestin, mankhwala a estrogen-progestogen, diphenin, rifampicin: kuchepa kwa hypoglycemic zotsatira za glycazide.

Zofanizira za Gliclazide MV ndi: Gliclazide-Akos, Glidiab, Glidiab MV, Glucostabil, Diabeteson MV, Diabefarm MV, Diabinax, Diabetalong.

Ndemanga pa Gliclazide MV

Gliclazide MV ndi gawo limodzi la zigawo zachiwiri za sulfonylurea ndipo amadziwika kwambiri ndi vuto la hypoglycemic, lomwe limalongosoleredwa ndi mgwirizano wapamwamba wa β-cell receptors (nthawi 2-5 nthawi yayitali kuposa m'mibadwo yam'mbuyomu). Izi zimakuthandizani kuti mukwaniritse zochizira zowonjezera pamlingo wochepetsetsa komanso kuchepetsa kuchuluka kwa zoyipa.

Malinga ndi ndemanga, MV Gliclazide imagwiritsidwa ntchito pamavuto a shuga mellitus (retinopathy, nephropathy poyambira matenda aimpso kulephera, angiopathy. Izi zimanenedwa ndi odwala omwe asamutsidwa kuti alandire mankhwalawa. Izi ndichifukwa choti imodzi mwazigawo za glycazide metabolites imakhudza ma microcirculation ambiri, kuchepetsa kuopsa kwa angiopathy komanso chiopsezo chokhala ndi zovuta zam'magazi (nephropathy ndi retinopathy). Nthawi yomweyo, kuthamanga kwa magazi mu conjunctiva kumathandizanso komanso kupindika kwamisempha kumatha.

Akatswiri ambiri amagogomezera kuti mukamalandira chithandizo ndi Gliclazide MV, ndikofunikira kupewa kufa ndi njala ndikupatsa zakudya zomwe zili ndi zakudya zamagulu ambiri. Kupanda kutero, potengera zakudya zama calorie ochepa komanso pambuyo pakuchita zolimbitsa thupi kwambiri, wodwala amatha kukhala ndi hypoglycemia. Ndi kupsinjika kwakuthupi, kusintha kwa mankhwala kumafunika. Mwa odwala ena, atamwa mowa panthawi ya mankhwala a Gliclazide MV, zizindikiro za hypoglycemia zinaonekeranso.

Gliclazide MV siyikulimbikitsidwa kuti izigwiritsidwa ntchito mwa odwala okalamba omwe amatha kukhala ndi hypoglycemia, chifukwa chake, motere, ndikofunikira kugwiritsa ntchito mankhwala ofupikitsa.

Odwala amadziwa kuphweka kwa kugwiritsa ntchito gliclazide mwa mapiritsi osinthika osinthika: amagwira ntchito pang'onopang'ono, ndipo gawo lokangalika limagawidwa mthupi lonse. Chifukwa cha izi, mankhwalawa amatha kumwa 1 nthawi patsiku, ndipo mankhwalawa ndi othandizira kawiri kuposa 2% ya gliclazide. Palinso malipoti oti atatenga nthawi yayitali mankhwala (zaka 3-5 kuyambira chikhazikitso), odwala ena adayamba kukana, zomwe zimafuna kuti pakhale mankhwala ena ochepetsa shuga.

Mlingo ndi makonzedwe

Mlingo weniweni wa mankhwalawa umatsimikiziridwa ndi dokotala. Nthawi yomweyo, zaka za wodwalayo, kupezeka kwake komanso kuopsa kwa zizindikiro zamatenda, komanso kuchuluka kwa kusala kudya kwamatumbo ndi maola 2 mutatha kudya, zimawerengedwa.

Malinga ndi malangizo a Gliclazide, muyeso woyamba wa tsiku ndi tsiku ndi 80 mg, avareji ndi 160 mg, ovomerezeka ndi 320 mg. Mankhwala ayenera kumwedwa kawiri pa tsiku 30-60 Mphindi asanadye.

Mlingo woyambirira wa MV Glyclazide ndi 30 mg. Ngati chithandizo chamankhwala sichikwanira kamodzi pa sabata ziwiri zilizonse, mlingo wake ungathe kuwonjezeka pang'onopang'ono mpaka mapiritsi a tsiku lililonse a 120 mg (mapiritsi 4).