Tsambali limapereka chidziwitso pazachidziwitso chokha. Kuzindikira ndi kuchiza matenda kuyenera kuchitika moyang'aniridwa ndi katswiri. Mankhwala onse ali ndi contraindication. Kufunsira kwa akatswiri ndikofunikira!

Ndi mankhwala ati omwe amathandizira kwambiri ndi kutentha thupi - paracetamol kapena aspirin?

Mankhwala onse awiri - paracetamol ndi aspirin amakhala ndi mphamvu yotsutsa antipyretic. Komabe, kuphatikiza pakuchepetsa kutentha, mankhwalawa ali ndi katundu wosiyana, womwe uyenera kukumbukiridwa kuti mumvetsetse kuti ndi mankhwala ati omwe ali munthawi imeneyi omwe angakhale abwino kwambiri kuchepetsa kutentha.

Kunena zowona, ziwopsezo za paracetamol ndi aspirin ziyenera kutchulidwa kuti sizofanana pankhaniyi pakuchepetsa kutentha. Aspirin ndiyothandiza kwambiri komanso imathamanga kutentha kuchepetsa kuposa Paracetamol. Komabe, palinso zina pazotsatira za mankhwalawa. Ngati palibe mbali zina zomwe mchitidwe wa mankhwalawa umasangalatsa munthu, atha kulandira chithandizo.

Koma ngati mungaganizire zina za machitidwe a paracetamol ndi aspirin, ndiye kuti aliyense ali ndi vuto lililonse pamlanduwo. Choyamba, paracetamol imadziwika kuti ndi mankhwala otetezeka kwambiri padziko lonse lapansi. Chifukwa chake, paracetamol imaloledwa kupatsirana komanso kudziwongolera pa kutentha kwambiri kwa thupi.

Aspirin bwino amachepetsa malungo, koma amatha kukhala mankhwala oopsa. Ngozi yeniyeni ya mankhwala omwe ali ndi Aspirin ndikuti amathandizanso pama cell omwewo monga ma virus ena omwe amayambitsa kuzizira. Zotsatira zake, maselo a chiwindi amakumana ndi zovuta komanso zotsatirapo zoipa nthawi imodzi kuchokera ku Aspirin ndi ma virus. Mothandizidwa ndi poizoni wa aspirin komanso ma virus, ma cell a chiwindi amawonongedwa, ndipo nthenda yoopsa komanso yoopsa yotchedwa Reye syndrome imayamba. Izi zimachitika chifukwa cha zovuta za Aspirin.

Reye's syndrome ndi matenda oopsa kwambiri, omwe amafa kwambiri omwe amafika 80 - 90%. Chifukwa chake, kugwiritsa ntchito Aspirin kutsitsa kutentha kumakhala pachiwopsezo china. Koma Paracetamol ilibe zoopsa zotere. Chifukwa chake, kusankha pakati pa Paracetamol ndi Aspirin, kuwonjezera pa kuyerekeza kugwira bwino kwawo, kuli ndi gawo linanso - kuchuluka kwa chiwopsezo. Aspirin ndibwino kutsitsa kutentha, koma kumatha kuyambitsa kuvulala koopsa, pomwe Paracetamol imakhala yolimba pakuwongolera kutentha, koma imakhala yotetezeka kwathunthu ndipo siyitsogolera kuimfa ngakhale ndi mankhwala ochulukirapo. Ndiye kuti, kusankha kumakhala pakati pa mankhwala othandiza koma owopsa komanso osagwira ntchito kwenikweni, koma otetezeka kwathunthu.

Ndi chifukwa cha mwayi wokhala ndi vuto la Reye's kuti Aspirin osavomerezeka kuti agwiritsidwe ntchito kuchepetsa kutentha mu matenda a virus. Kuti muchepetse kutentha komwe kumayendera ndi ma virus, tikulimbikitsidwa kugwiritsa ntchito kukonzekera kwa Paracetamol. Ndi matenda aliwonse obwera chifukwa cha mabakiteriya, monga tonsillitis, pyelonephritis ndi ena, Aspirin ndiotetezeka kwathunthu ndipo angagwiritsidwe ntchito ngati antipyretic yogwira mtima kwambiri.

Zoyenera kusankha: Aspirin kapena Paracetamol?

Ngati mukufunikira kusankha antipyretic yogwira mtima kwambiri, funso limakhalapo nthawi zambiri, lomwe limakhala labwino - Aspirin kapena Paracetamol. Mankhwalawa ali ndi katundu omwewo: amachepetsa kutentha kwa thupi (kutentha thupi), kusiya kupweteka pang'ono. Koma mankhwalawa ali ndi magawo osiyanasiyana othandizira, kusiyana m'njira zomwe zimachitika ndi contraindication.

Aspirin kapena Paracetamol amachepetsa kutentha kwa thupi (fever), siyani kupweteka pang'ono.

Khalidwe la Aspirin

Aspirin amapangidwa ndi kampani yaku Germany yopanga mankhwala a Bayer AG. Njira ya kukonzekera ndi mapiritsi oyera a biconvex, omwe amalembedwa (Bayer mtanda ndi mawu akuti ASPIRIN 0.5).

Yogwira pophika: acetylsalicylic acid.

Omwe amathandizira: mapira a chimanga ndi cellcrystalline cellulose.

Aspirin amakhala ndi acetylsalicylic acid (ASA) mu muyeso wa 500 mg / tabu. Mankhwala ndi a gulu la mankhwala osapatsa mankhwala a anti-yotupa a NSAIDs. ASA ndilinso yosaphatikizidwa ndi narcotic analgesic ndi antipyretic, chifukwa imakhudza dongosolo lamanjenje lamkati komanso malo a ululu ndi thermoregulation yomwe ili mu ubongo. Acetylsalicylic acid ndi gulu loyamba la NSAIDs, i.e. Ndi chinthu chomwe chimatchedwa anti-kutupa ntchito.

Limagwirira ntchito ASA zachokera kuletsa kosasintha kwa cycloo oxygenase (COX) ma enzyme a 1st ndi 2nd. Kuponderezedwa kwa mapangidwe a COX-2 kuli ndi antipyretic ndi analgesic zotsatira. Kuletsa kapangidwe ka COX-1 kumakhala ndi zotsatirapo zingapo:

• kuletsa kapangidwe ka prostaglandins (PG) ndi ma interleukins,
• utachepa mphamvu ya minofu,
• kuletsa kwa thromboo oxygenase kaphatikizidwe.

Zotsatira za ASA pathupi zimadalira mlingo. Izi zikutanthauza kuti pharmacodynamics ya zinthu zimasiyana malinga ndi tsiku.

Kutenga ASA mumadontho ang'onoang'ono (30-325 mg / tsiku) imagwiritsidwa ntchito popewa matenda amtima omwe angayambike chifukwa chowonjezera magazi.

Pa mlingo uwu, acetylsalicylic acid amawonetsa katundu wa antiaggregant: amalepheretsa mapangidwe a thromboxane A2, omwe amachititsa kuti magazi azigwirizana komanso amakwiyitsa kwambiri vasoconstriction.

Kuti muchepetse kupweteka kwapakati komanso kuchepetsa kutentha kwa thupi pa pyrethic panthawi ya malungo, pafupifupi Mlingo wa ASA (1.5-2 g / tsiku) ndiwothandiza, wokwanira kutsekereza ma enzyme a COX-2. Mlingo wawukulu wa acetylsalicylic acid (4-6 g / tsiku) amachepetsa mphamvu yotupa, chifukwa ASA imalepheretsa michere ya COX-1, ikuletsa mapangidwe a PG.

Mukamagwiritsa ntchito ASA mu mlingo womwe umapitilira 4 g / tsiku, mphamvu yake ya uricosuric imapangidwanso, ndipo kugwiritsa ntchito Mlingo wocheperako komanso wapakati tsiku lililonse (mpaka 4 g / tsiku) kumabweretsa kuchepa kwa kwamikodzo acid.

Zotsatira zoyipa za Aspirin ndi gastrotoxicity yake, yomwe imayamba chifukwa cha kuchepa kwa cytoprotection ya m'mimba ndi duodenal mucosa akakumana ndi acetylsalicylic acid. Kuphwanya mphamvu ya maselo kuchira kumayambitsa mapangidwe akhungu lastative-zilonda zam'makoma am'mimba thirakiti.

Kuti achepetse vuto la ASA, Bayer adapanga Aspirin Cardio - mapiritsi okhala ndi zotsekemera ndi ma dragees. Mankhwalawa amayang'aniridwa kupewa matenda a mtima, motero, ASA imapezekamo m'miyeso yotsika (100 ndi 300 mg).

Momwe Paracetamol Imagwira

Paracetamol mwanjira ya mapiritsi (200, 325 kapena 500 mg / tabu.) Imapezeka kuchokera kwa opanga osiyanasiyana.

Zomwe zimagwira ndi paracetamol (acetaminophen).

Omwe amathandizira: wowuma chimanga, wowuma wa mbatata, gelatin, sodium ya croscarmellose, stearic acid.

Paracetamol ndi m'gulu lachiwiri la NSAIDs (mankhwalawa omwe ali ndi mphamvu zotsutsana ndi zotupa). Acetaminophen ndi zotumphukira za paraaminophenol. Limagwirira ntchito za chinthu ichi zachokera pakutseka kwa ma enzyme a COX ndi kuletsa kwa kaphatikizidwe ka GHG.

Mphamvu yotsutsa-yotupa imachitika chifukwa chakuti ma peroxidases a zotumphukira minofu ya cell amapangitsa kuti ma cycloo oxygenase (COX-2) ma enzymes omwe amachitika chifukwa cha zochita za Paracetamol. Zotsatira za acetaminophen zimafikira kokha ku dongosolo lamanjenje lamkati komanso malo ophunzitsira ndi kupweteka mu ubongo.

Kutetezedwa kwa Paracetamol pamatumbo am'mimba kumafotokozedwa ndi kusapezeka kwa chopinga cha GHG synthesity zotumphukira komanso kusungidwa kwa ziwalo za cytoprotective. Zotsatira zoyipa za acetaminophen zimagwirizanitsidwa ndi hepatotoxicity, chifukwa chake, mankhwalawa amaphatikizidwa kwa anthu omwe ali ndi chidakwa. Zowopsa za chiwindi zimatheka chifukwa cha kuphatikiza kwa Paracetamol ndi NSAID ena kapena anticonvulsants.

Kuyerekezera Mankhwala

Mankhwalawa ndi amodzi a noncotic analgesics ndi antipyretics, ndipo amaphatikizidwanso m'gulu la mankhwala osapatsa mankhwala a anti-yotupa (NSAIDs).

Mankhwala nawonso ali ndi katundu wa antipyretic ndipo amagwiritsidwa ntchito kuti athetse kutentha thupi. Mankhwalawa amagawiridwa m'mafakisoni popanda mankhwala.

Zizindikiro za mankhwalawa ndizofanana:

• kuchepa kwa kutentha kwambiri
• kuthetsa ululu wapakatikati
• kuchepa kwamphamvu kwa kutupa.

Contraindication wa mankhwala onsewa ndi:

• chiwindi, impso kapena mtima,
• shuga-6-phosphate dehydrogenase akusowa.

Aspirin sagwiritsidwa ntchito pochiza ana chifukwa choopsa chachikulu chotenga chiwindi kapena matenda a Reye syndrome.

Kodi pali kusiyana kotani?

Mankhwalawa ali ndi ntchito zotsutsana ndi zotupa: Paracetamol - ofooka, Aspirin - wotchulidwa.

Popeza magawo omwe amagwiritsidwa ntchito m'mankhwala awa ndi osiyana, ma contraindication akuluakulu pakudya kwawo amakhalanso osiyana. Aspirin amatsutsana mu:

• hemorrhagic diathesis,
• stratation of aortic aneurysm,
• zilonda zam'mimba (kuphatikizapo mbiri),
• chiopsezo chotaya magazi m'matumbo,
• tsankho ku ASA ndi ma NSAID ena,
• Mphumu ya bronchial yovuta kwambiri ndi polyposis yammphuno,
• hemophilia
• matenda oopsa a portal
• kusowa kwa vitamini K

Ngakhale njira zothetsera antipyretic komanso anti-yotupa m'thupi, Aspirin sagwiritsidwa ntchito kuchitira ana chifukwa choopsa chotenga chiwopsezo cha chiwindi chachikulu mwa ana omwe ali ndi kachilombo ka matenda a Reye's syndrome. Simungathe kugwiritsa ntchito mankhwalawa ndi zilonda zam'mimba ndi duodenum komanso ndi chiopsezo chotaya magazi mkati. Aspirin amatsutsana ndi ana osakwana zaka 15, azimayi omwe ali ndi pakati (I ndi III trimesters), ndi amayi oyamwitsa.

Paracetamol osavomerezeka kuti igwiritsidwe ntchito ndi:

• hyperbilirubinemia,
• virus hepatitis
• kuwonongeka kwa chiwindi cha chidakwa.

Acetaminophen imawonedwa kuti ndi NSAID yotetezeka kuposa acetylsalicylic acid, chifukwa sizoyambitsa kukula kwa Reye's syndrome, sikuti ndi gastrotoxic, ndipo sizimachepetsa thrombosis (ASA yokha yomwe ili ndi antiplatelet katundu). Chifukwa chake, Paracetamol tikulimbikitsidwa ngati pali zotsatirazi zotsutsana ndi Aspirin:

• Mphumu ya bronchial,
• mbiri yazilonda
• zaka za ana
• mimba
• Nthawi yonyamula mkaka.

Chifukwa chake, paracetamol imatha kutengedwa ndi ana, amayi oyembekezera komanso oyembekezera.

Paracetamol imakhudza makamaka dongosolo lamanjenje komanso magwiridwe antchito a ululu ndi malo opatsirana. Chifukwa chake, mankhwalawa amagwira ntchito ngati analgesic. Zofooka zofowoka zotsutsana ndi zotupa zimawonetsedwa pokhapokha pazinthu zina za peroxide m'matumbo (omwe ali ndi nyamakazi, kuvulala kwambiri kwa minofu), koma osati ndi rheumatism. Aspirin imathandizira ululu wammbuyo wapadera komanso kupweteka kwamwano.

Kuchepetsa kutentha pakati pa kutentha thupi komanso kuthana ndi kupweteka kwa mutu, ndikofunikira kugwiritsa ntchito Paracetamol, chifukwa imakhala ndi zovuta zochepa.

Zomwe zimakhala zotsika mtengo

Mapiritsi a Paracetamol ndi otsika mtengo kwambiri kuposa aspirin.

Zomwe zili bwino - Aspirin kapena Paracetamol

Kusankha kwa mankhwala kumatengera zotsatirazi:

• mtundu wamatendawa (wokhala ndi kachilombo koyambitsa matenda, Aspirin akupatsirana),
• zaka odwala (Aspirin sagwiritsidwa ntchito ngati ana),
• cholinga cha mankhwala (kutsitsa kutentha kwa thupi kapena kulimba kwa njira yotupa, kuletsa kwa thrombosis kapena kupweteka kwapweteka).

Popewa matenda amtima, ndi a Aspirin okha omwe amagwiritsidwa ntchito, chifukwa ASA yaying'ono Mlingo wamtunduwu umalepheretsa kaphatikizidwe ka thromboxane A2. Paracetamol ilibe katundu.

Mukamasankha analgesic, muyenera kuganizira mtundu wa zowawa. Ndi kupweteka kwamisempha komanso kuwonongeka kwa zotumphukira zotupa, Paracetamol siyothandiza, popeza mphamvu yake imangokhala pakati pa dongosolo lamanjenje. Zikatero, ndibwino kugwiritsa ntchito Aspirin.

Poletsa kutukusira kwa wodwala wachikulire, kugwiritsa ntchito Aspirin kumathandizanso, chifukwa kumakhala ndi tanthauzo lodana ndi kutupa.

Kutentha

Monga antipyretic mankhwala a fever, onse Aspirin ndi Paracetamol amagwiritsidwa ntchito.

Aspirin amaletsedwa kugwiritsidwa ntchito ngati ana chifukwa cha chiwopsezo chachikulu chotenga matenda a Reye pothana ndi matenda oyambitsidwa ndi ana. Kuti muchepetse kupweteka komanso kuchepetsa kutentha kwa thupi mwa mwana, tikulimbikitsidwa kugwiritsa ntchito Paracetamol malinga ndi malangizo.

Malingaliro a madotolo

Petrova A. Yu., Wachipatala: "Ndi bwino kugwiritsa ntchito ana, ndikofunika kugwiritsa ntchito mankhwala omwe ali ndi paracetamol ngati madzi (Panadol)."

Kim L. I., wothandizira: "Mankhwalawa samachiza matenda omwe amayambitsa - amangochepetsa ululu wa wodwalayo. Mutha kugwiritsa ntchito mankhwalawa popanda kulandira chithandizo kwa masiku osaposa atatu. Ngati chizindikiro cha chimfine sichitha, ndiye kuti chitetezo cha mthupi sichitha kuponderezaku chokha. Kuti mupewe zovuta, muyenera kukaonana ndi dokotala. ”

Ndemanga za Odwala pa Aspirin ndi Paracetamol

Alina, wazaka 24, Ufa: "Aspirin ndi mankhwala odula omwe ali ndi zotsutsana zambiri. Paracetamol sikuti ilibe vuto, koma yotetezeka. "

Oleg, wazaka 36, ​​Omsk: "Ndikugwiritsira ntchito Aspirin (mapiritsi osungunuka) pochiza mutu kapena chimfine. Sindinazindikire vuto lililonse. ”

Khalidwe la Paracetamol

Mankhwalawa amathandizira kuchepetsa kutentha kwa thupi. Amachotsa zowawa, amaletsa kukula kwa njira yotupa. Zomwe zimagwira pophika ndi paracetamol. Imalepheretsa mapangidwe a ma prostaglandins ndipo imagwira ntchito pa thermoregulation Center mu diencephalon. Chidacho chimaletsa kuwoneka ngati ululu, chimachotsa kutentha thupi. Ili ndi mphamvu yotsutsa-kutupa.

Fotokozerani mankhwala kupweteka kumbuyo, minofu, mafupa. Amathandizanso kupweteka kwam'mutu, kusakhazikika pamimba pamimba. Ndikulimbikitsidwa kuti chimfine ndi chimfine chichepetse kutentha kwa thupi ndikusintha bwino. Kulandila ndi kutsutsana zotsatirazi matenda ndi mikhalidwe:

• mimba
• yoyamwitsa
• uchidakwa
• kuwonongeka kwambiri kwa chiwindi ndi impso,
• matenda a magazi
• Kuchepetsa kuchuluka kwa magazi,
• shuga-6-phosphate dehydrogenase akusowa.

Mankhwala angayambitse thupi lawo siligwirizana. Nthawi zina, anaphylaxis, nseru, bronchospasm, urticaria, ndi m'mimba ululu zimawonedwa pambuyo makonzedwe. Zodzazidwa bwino ndi chakudya. The yogwira pophika limamangidwa mapuloteni, amapanga biotransformation mu chiwindi ndipo chimbudzi mu mawonekedwe a ofooka metabolites mu mkodzo kwa maola 8-10. Siziwononga moyenera mulingo wamadzi ndi mchere wamthupi. Imayamba kuchita mkati mwa mphindi 15-30.

Zomwe zili bwino - Paracetamol kapena Aspirin

Paracetamol ndiwotetezeka pamimba. Itha kutengedwa ngakhale motsutsana ndi ulceric ulcer, ngakhale chiwindi chimakhala ndi mankhwalawa. Mankhwalawa amathandizira thupi, nthawi zambiri odwala amasiya ndemanga yotsika ntchito.Ndikumva kupweteka kwambiri, kutentha thupi komanso kutupa, ndibwino kumwa acetylsalicylic acid.

Ndi chimfine

Kwa chimfine, munthu wamkulu amatenga asidi acetylsalicylic. Mankhwalawa amalimbana ndi kutentha, kutupa komanso thupi kupweteka pang'ono. Kuti muwonjezere kugwira bwino ntchito, dokotalayo amapereka mankhwala othandizira.

Muubwana, ndikwabwino kutenga Paracetamol. Imagwira modekha, kuti musawope kuyipa. Perekani aspirin kwa ana osakwana zaka 15. Iyenera kutengedwa molingana ndi mlingo womwe umawonetsedwa mu malangizo komanso pokhapokha ngati pali contraindication.

Ndemanga za Odwala pa Paracetamol ndi Aspirin

Anna, wazaka 29, Murmansk

Aspirin ndi wabwino kwambiri kuposa Paracetamol. Ndinatenga ndi ARVI. Kutentha kumatsikira mkati mwa ola limodzi kupita pamikhalidwe yokhazikika. Mutu umachoka pang'ono ndipo zinthu zimasintha. Ndimalola pazifukwa zadzidzidzi, chifukwa mankhwalawa amavulaza thupi ndikugwiritsa ntchito pafupipafupi.

Kristina, wazaka 35, Samara

Paracetamol anaperekedwa kwa mwana. Kutentha kumagwera pang'onopang'ono, koma kwanthawi yayitali. Ili ndi zochepa zotsutsana ndi zoyipa. Pamodzi ndi antipyretics, muyenera kumwa zamadzi zambiri ndi kumwa mavitamini.