Matenda a shuga

Njira zodziwonera hyperglycemia yophatikizira ndi monga kutsimikiza kwa mapuloteni a glycosylated, nthawi ya kukhalapo kwa yomwe m'thupi limapangika kuyambira milungu iwiri mpaka 12. Kulumikizana ndi glucose, amadziunjikira, titero, mtundu wa chida chokumbukira chomwe chimasunga zidziwitso za kuchuluka kwa glucose m'magazi ("memory glucose"). Hemoglobin A mwa anthu athanzi ili ndi kachigawo kakang'ono ka hemoglobin A1c, kamene kamakhala ndi glucose. Gawo la hemoglobin wa glycosylated (HbA1c) ndi 4-6% ya kuchuluka kwa hemoglobin.

Odwala omwe ali ndi matenda osokoneza bongo omwe amakhala ndi hyperglycemia yokhazikika komanso kulolerana kwa glucose (osakhalitsa hyperglycemia), njira yophatikizira shuga m'magulu a hemoglobin imawonjezereka, omwe amaphatikizidwa ndi kuwonjezeka kwa gawo la HbAic. Posachedwa, tizigawo tina tating'onoting'ono ta hemoglobin, Ala ndi A1b, amenenso timatha kumangiriza ku glucose, tapezeka. Odwala odwala matenda a shuga, zomwe zimapezeka mu hemoglobin A1 m'mwazi zimaposa 9-10% - kufunika kwa anthu athanzi.

Hyperglycemia wosakhalitsa umayenda limodzi ndi kuwonjezeka kwa milingo ya hemoglobin A1 ndi A1c kwa miyezi 2-3 (mkati mwa moyo wamaselo ofiira a magazi) komanso pambuyo pamagulu a shuga. Column chromatography kapena njira zopangira calorimetry zimagwiritsidwa ntchito kudziwa glycosylated hemoglobin.

Tanthauzo la IRI

Yesani ndi tolbutamide (malinga ndi Unger ndi Madison). Pambuyo poyesa shuga m'mimba yopanda kanthu, 20 ml ya 5% yankho la tolbutamide imaperekedwa kwa wodwalayo ndipo pambuyo mphindi 30 shuga imayesedwanso. Mwa anthu athanzi labwino, kuchepa kwa shuga m'magazi ndi oposa 30%, ndipo mwa odwala omwe ali ndi matenda ashuga - osakwana 30% oyambira. Odwala omwe ali ndi insulinoma, shuga m'magazi amatsika ndi oposa 50%.