Meldonium ": malangizo ogwiritsira ntchito, ndemanga, analogi

Mavuto mu mtima ndi nthawi zambiri amapangitsa kuti wodwalayo sangakhale moyo wathanzi. Kutopa kwambiri, kufupika, komanso kusowa tulo. Popanda kuthandizidwa ndi katswiri sangathe. Dokotalayo amapereka mankhwala omwe angathandize kusintha wodwala. Zotsatira zabwino zimawonetsedwa ndi mankhwala "Meldonium". Malangizo ogwiritsira ntchito amafotokozera momwe mungamwe mankhwalawo moyenera.

Njira yotulutsira mankhwala ndi kapangidwe kake

Mankhwalawa amamasulidwa mu mawonekedwe a makapisozi ndi yankho. Palinso dzina lina - m'mafakitala nthawi zambiri mumatha kupeza mapiritsi a Mildronate. Chida ichi chili ndi mawonekedwe ofanana ndipo chitha kugwiritsidwa ntchito ngati mankhwala munthawi yomweyo. Chofunikira chachikulu pakupanga ndi meldonium dihydrate. Colloidal silicon dioxide, wowuma wa mbatata, komanso calcium stearate amagwiritsidwa ntchito ngati zinthu zothandiza m'mabotolo. Mu yankho, madzi oyeretsedwa amapezekanso.

Pambuyo pakukonzekera pakamwa, makapisozi amatengedwa mwachangu kuchokera m'mimba. Kwambiri bioavailability ndi 78% ndipo zimatheka maola ochepa. Chosakaniza chachikulu chogwira ntchito chimapukusidwa pafupifupi ndi impso patatha maola 6 mutatha kumwa mankhwalawo.

Atha kukhala gawo la zovuta kuchizira matenda a mtima a coronary "Meldonium". Mtengo wa makapisozi umakhala wotsika pang'ono kuposa mtengo wa yankho, motero nthawi zambiri ndiye njira yoyamba yomwe imakhazikitsidwa. Anthu omwe ali ndi vuto losatha mtima amamwa mankhwala kuti atsimikizire kuti magwiridwe antchito aliwonse. Kodi mankhwalawa "Meldonium" amatani? Mapiritsi amathandizira wodwalayo kukhala wathanzi, amamuwonjezera ntchito.

Contraindication

Sikuti aliyense angathe kuikidwa mankhwala "Meldonium". Malangizo ogwiritsira ntchito akuwonetsa kuti mankhwalawo atha kukhala owopsa kwa anthu omwe ali ndi chidwi chowonjezera. Musanagwiritse ntchito malonda, ndikofunikira kufunsa dokotala. Anthu omwe ali ndi matenda oopsa a mtima dongosolo, ndikofunika kupita kuchipatala.

Mankhwala "Mildronate" ("Meldonium") saikidwa kwa odwala ochepa. Amayi pa nthawi yoyembekezera komanso mkaka wa m`mawere ayeneranso kukana kugwiritsa ntchito mankhwalawa. Chosakaniza chachikulu chogwira ntchito chimatha kutsegula mawonekedwe a zodabwitsika pakukula kwa mwana wosabadwayo.

Malangizo apadera

Funsani dokotala musanatenge Meldonium. Makapisozi amatchulidwa mosamala kwa odwala omwe ali ndi vuto la impso. Musanayambe chithandizo, ndikofunikira kuti mukayezetse kuchipatala. Mankhwalawa si mankhwala a mzere woyamba wochizira pachimake. Makapisozi kapena yankho limatha kuphatikizidwa pokhapokha pakuvuta.

Meldonium dihydrate siyimakhudza mayendedwe a psychomotor a munthu. Mankhwalawa amatha kugwiritsidwa ntchito ndi anthu omwe ntchito zawo zimagwirizanitsidwa ndi kasamalidwe kazinthu zovuta.

Mankhwala "Meldonium" ayenera kugwiritsidwa ntchito moyenera. Malangizo ogwiritsira ntchito akuwonetsa kuti mankhwalawa angayambitse kukulitsa kosangalatsa. Pankhaniyi, tikulimbikitsidwa kuti titenge m'mawa. Chizolowezi cha tsiku ndi tsiku chimakhazikitsidwa payekhapayekha, kutengera mtundu wa nthenda ya wodwala, komanso machitidwe ake. Mlingo umodzi mukamamwa pakamwa sayenera kupitirira 1 gram. Kuchulukitsa kwa phwando kumadalira umboni. Mothandizidwa ndi mtsempha wa mkodzo, njira imodzi ndi 0,5 ga. Mankhwala amtunduwu sagwiritsidwa ntchito mopitilira kawiri pa tsiku.

Zotsatira zoyipa

Zotsatira zoyipa zomwe mapiritsi a Meldonium angayambitse? Malangizo ogwiritsira ntchito akufotokozera zizindikiro zomwe zingachitike mukamamwa mankhwala ambiri. Mbali yamtima, odwala atha kukhala ndi tachycardia, komanso kusintha kwa kuthamanga kwa magazi kumayang'aniridwa. Kuchokera kumbali ya dongosolo lamanjenje lamkati, zoyipa zimawonekera mwa mawonekedwe amisala yokhudzana ndi psycho, kusokonezeka kwa tulo. Odwala nthawi zambiri amadandaula za migraines ndi chizungulire.

Nthawi zina, thupi limayamba kusintha. Odwala omwe amakonda kuzizira amayenera kumwa mankhwalawa "Meldonium" mosamala. Ndemanga zikuwonetsa kuti hypersensitivity imawonetsedwa makamaka mu mawonekedwe a eczema ndi zotupa pakhungu.

Mitu ya mankhwalawa

Kodi ndingatani kuti ndi "Meldonium"? Mavuto a mankhwala amatha kuvomerezedwa ndi katswiri. Muzochita zachipatala, mankhwala ambiri omwe ali ndi mawonekedwe ofanana amagwiritsidwa ntchito. Njira yothetsera Idrinol ndiyotchuka. M'mafakitala, mutha kupezanso mankhwala ngati mapiritsi. Chofunikira chachikulu pakupanga ndi meldonium dihydrate. Monga zinthu zothandiza, madzi a magnesium stearate, talc ndi oyeretsedwa amagwiritsidwa ntchito.

Yankho la Kardionat ndi chinthu china chodziwika bwino cha meldonium chomwe chimagwiritsidwa ntchito pakufalikira mwamphamvu kwa minofu. Mankhwalawa amathandizira kukonza magazi. Chifukwa cha izi, mpweya umaperekedwa ku ziwalo zonse ndi machitidwe mwachangu. Wodwalayo amayamba kumva bwino. Zotsatira zoyipa sizimayamba. Ngati bongo, tachycardia kapena kusintha kwa magazi kumaonedwa. Kumwa mankhwala osakambirana ndi dokotala sikulimbikitsidwa.

Odwala amadziwa kuti mankhwalawa amawonetsa zotsatira zabwino m'masiku oyamba kugwiritsa ntchito. The bioavailability wa mankhwalawa kwambiri. Chifukwa chake, kuyambira pa chiyambi, wodwalayo amamva kuwonjezeka kwa mphamvu ndi mphamvu. Ngati mumamwa mankhwalawa moyenera pagululi, zovuta zoyipa sizimayamba. Sizodziwika kuti Meldonium ndi wotchuka masiku ano.

4 ndemanga

Titha kunena popanda kukokomeza kuti palibe ngakhale mankhwala amodzi m'mbiri yonse yamakono omwe "adalimbikitsidwa",, kampani yopanga sikunapange ndalama pachiwonetsero chotsatsa padziko lonse lapansi. Tikuyankhula za zotsatizana zosokoneza mbiri mu "masewera akulu" momwe meldonium (INN), momwe amatchulidwira kunja, kapena Mildronat, monga amatchedwa ku Russia (dzina lamalonda), adayenera kutsutsidwa.

Zonsezi zidayamba pa Januware 1 omaliza, 2016. Inali nthawi imeneyi pamene WADA (World Anti-Doping Agency) imabweretsa meldonium, aka Mildronat, mndandanda wazachuma zoletsedwa. Cholinga chake chinali chakuti cytoprotective ndi metabolic zotsatira zitha (mwina) kusintha myocardium kwambiri kuti mtima ukhale wolimba komanso wolimba kwambiri, zomwe zingapangitse kuti zitheke, motero ndalama zambiri.

Mbiri ya mankhwalawa idaphatikizika. Inapangidwa koyamba mu Latvia SSR ndi Ivars Kalvins, ndipo poyamba amafuna kuti agwiritse ntchito pochotsa zinthu zakupha za rocket mafuta (dimethylhydrazine). Koma pophunzira kuopsa kwa mankhwalawa mu nyama, zotulukapo zake zidapezeka kuti kuyambira 1976, mankhwala otchedwa Mildronate adalembedwa ku USSR, kenako ku USA (kuyambira 1984).

Sizikudziwika chifukwa chake, koma ku USA mankhwalawo anali "opanda nzeru": mmbuyomo m'zaka za m'ma 80 zapitazo anali oletsedwa. M'dziko lathu, kugwiritsa ntchito mapiritsi a Mildronate kunayamba ngati mankhwala ankhondo, kenako, kutha kwa USSR, adasanduka mankhwala ogwiritsidwa ntchito kwambiri machitidwe azachipatala wamba.

Zochita ndi magwiridwe antchito

Chithunzi cha Mildronate cha makapisozi ndi yankho la jakisoni

Mankhwala amachita pa minofu ya mtima kudzera kagayidwe mafuta acids. Zotsatira zake, kuchuluka kwa zinthu zomwe zimakhala ndi ma-oxidized mu ma myocardial cell - myocardiocytes - zimachepa, ndipo mwayi wa oxidation waulere umachepa. Nthawi zambiri, zinthu zonsezi zimasokoneza kayendedwe ka ATP - molekyulu yapadziko lonse - "batri", yomwe imapereka maselo onse ndi mphamvu.

Zotsatira zake, myocardiocytes amatha kugwiritsa ntchito bwino glucose, ndipo kupatsa mphamvu kwa myocardial kumakhala bwino. Ndipo izi zimatsogolera mwachidziwikire kuti mtima umayenda bwino ndikuwonjezera katundu. Kuphatikiza apo, ATP imagwira ntchito myocardium yokha. Magulu angapo a asayansi apeza kuti mankhwalawa amapezeka bwino ngati thupi liyenera kugwira ntchito mwa malo a celloxia. Mildronate amalimbikitsa kuchira msanga pambuyo pogwira ntchito mwamphamvu, kuphatikiza kuchira kwam'maganizo.

Mankhwalawa amalola othamanga kuti angodzipereka okha momwe angathere ndikupereka "zonse zabwino" pakuphunzitsidwa. Komabe, si mahomoni, alibe mphamvu ya anabolic, ndipo sitsogolera pakukula kwa minofu. Zimalepheretsa kuwonongeka kwa mtima, zimathandizira kufalikira kwa neural, komanso kupewa ubongo wa hypoxia.

Zizindikiro ndi mawonekedwe akumasulidwa

Kodi chimathandiza Mildronate ndi chiyani? Mwachilengedwe, chikalata chovomerezeka (chomwe, mwa zina, WADA chimapangidwanso) ndizoyenera kugwiritsa ntchito. Mitundu yotulutsidwa kwambiri ndi makapisozi 250 ndi 500 mg, komanso mawonekedwe a makolo mu ampoules (5 ml) a 10% yankho. Njira yothetsera vutoli imayendetsedwa kudzera m'mitsempha, intramuscularly, ndi parabulbarno (mu ophthalmology).

Ganizirani mlingo woyenera - "Mildronate" 500, ndikutsegulira malangizo ogwiritsira ntchito:

Mankhwala akuwonetsa angina pectoris ndi mitundu yosiyanasiyana ya myocardial ischemia, komanso matenda amtima woopsa,
mankhwalawa aakulu mtima kulephera (otsika contractile myocardial ntchito),
ndi cardiomyopathies ochokera kumayendedwe osiyanasiyana komanso ndi myocardial dystrophy,
zomwe zimawonetsedwa chifukwa cha stroke ischemic, cerebrovascular pathology ndi dementia,
kutopa ndi kuchepa kwa ntchito,
ngati pali katundu wowonjezereka, kuphatikiza masewera,
mankhwalawa uchidakwa (ndi kuchotsedwa kwa zizindikiro zochotsa).

Umenewo ndiye umboni wonse. Koma, kwenikweni, mankhwalawa amatha kuwonjezera kupirira, amawonjezera kukana kupsinjika, amathandizira dongosolo lamkati lamanjenje, amathandizira kuchira kwa thupi.

Ichi ndichifukwa chake madokotala ambiri adayamba kupatsa Mildronate kwa wodwala aliyense, limodzi ndi matenda komanso kupewa. Zowonadi, mankhwalawa adakhala "panacea" kwa anthu omwe akukayikira, nkhawa komanso hypochondria. Amakhulupirira kuti ngati kupita kwa adotolo sikunathe ndi mankhwala omwe amupeza, ndiye kuti ulendowo sunaphule kanthu, ndipo dokotalayo ndi woipa. Mildronat amalemekeza izi.

Mildronate - malangizo ndi ntchito

Momwe mungagwiritsire ntchito mankhwalawa?

Mildronate imatha kukhala yosangalatsa, komanso imayambitsa chisokonezo cha kugona. Chifukwa chake, iwo omwe amachigwiritsa ntchito kwa nthawi yoyamba, ndikulimbikitsidwa kuti asamamwe pambuyo pa 17.00 (ngati kugona mwakuthupi kumakonzekera usiku), koma ndibwino kuti muchepetse phwando lakum'mawa. Pali mitundu yosiyanasiyana ya mankhwalawa omwe amamwa mankhwalawa, kutengera matendawa:

Myocardial infarction ndi mitundu ya matenda a mtima ofunikira amafunika mpaka 1000 mg patsiku, mpaka miyezi 1.5. Phwando
Ndi myocardial dystrophies ndi cardiomyopathies, 500 mg kamodzi ndikokwanira, kwa masiku 10-14,
Mu pachimake cerebrovascular ngozi ya ischemic chikhalidwe (mikwingwirima, chosakhalitsa kuwukira), mankhwalawa kutumikiridwa m`nsinga, mwachitsanzo, kuphatikizapo shuga, insulin ndi potaziyamu mankhwala ena. Pambuyo pa jekeseni, 1000 mg imayikidwa tsiku lililonse m'mawa, kapena 500 mg ya Mildronate kapisozi (m'mawa ndi masana) kwa 1 mpaka 2 miyezi.

Kugwiritsa ntchito jakisoni wa Mildronate kumasonyezedwanso ngati borus ya intravenous. Tiyenera kukumbukira kuti mulingo umodzi mu 5 ml ndi wofanana ndi kapisozi "yayikulu" mu 500 mg ya mankhwalawa, chifukwa zomwe zili meldonium ndi 100 mg pa 1 ml yankho.

Ngati vuto la matenda okomoka kwambiri a ubongo (matenda amtundu wamatumbo, ischemia), mankhwalawa amawonetsedwa kwa 500 mg kamodzi patsiku, komanso kwa nthawi yayitali - mpaka miyezi iwiri,
Kulandila othamanga, komanso kwa omwe achita masewera olimbitsa thupi, amalimbikitsidwa pa mlingo wa 500 mpaka 1000 mg tsiku lililonse. Kutalika kwakuvomerezedwa ndiku kuyambira pa 2 mpaka 3 milungu,
Monga gawo la zovuta zochizira zakumwa zoledzeretsa, mankhwalawa akuwonetsa muyezo waukulu - mpaka 2000 mg patsiku, wogawidwa mu 4 waukulu. Njira ya mankhwala yochepa - pafupifupi - masiku 7.

Anthu ambiri amafunsa - ndi chothandiza kwambiri: kumwa mapiritsi a Mildronate, kapena jakisoni? Kuti muyankhe funsoli molondola, muyenera kulozera ku ma pharmacokinetics ndi pharmacodynamics a mankhwalawo. Amadziwika kuti kuchuluka kwambiri m'madzi a m'magazi kumachitika pakatha maola 1 mpaka awiri atatha kumwa.

Mankhwala sayenera kudutsa m'chiwindi kuti ayambe kugwira ntchito. M'malo mwake, imawonongeka m'chiwindi, ndikusintha ma metabolites 3 mpaka 6 patatha nthawi yotsekemera. Chifukwa chake, ndibwino kugwiritsa ntchito jekeseni, popeza pamenepa gawo loyambirira kudzera pachiwindi silili kwina (atamwa mankhwala a duodenum ngati makapisozi). Zachidziwikire, chifukwa cha izi payenera kukhala mikhalidwe yonse komanso umboni woyenera.

Analogs ndi ma enron Mildronate

Kuphatikiza pa Mildronate, mankhwala Idrinol (Sotex) amapezeka pamsika wapakhomo. Komanso, chinthu chogwira ntchito (meldonium) chili ndi zolemba zotsatirazi za Mildronate:

Meldonium wokhudzidwa ndi "Biochemist",
"Angiocardil" pamaupanga opangidwa ndi Novosibirsk Chemical Farm (OJSC "Novosibirskkhimpharm"),
"Cardionate" yopangidwa ndi STADA CIS ndi mankhwala wamba opangidwa ku Russian Federation.

Imapezeka m'mapiritsi a 250 mg, komanso ma ampoules a ndende yomweyo monga Mildronate woyambirira - 5 ml, 100 mg / ml.

Chiti ndi chiyani - "Cardionate" kapena "Mildronate"? Kuchokera pamawonedwe azachuma, kutenga 1000 mg ya Cardionate tsiku lililonse kwa mwezi umodzi kumangotenga ma ruble 231 (mtengo wotsika kwambiri), ndikumamwa mankhwala oyamba - ma ruble 533. Koma ngati tikulankhula zothandiza, ndiye kuti mankhwalawo amakhala abwino nthawi zonse, chifukwa zinthu zoyambira zimakhala zodetsedwa nthawi zonse.

Kuphatikiza apo, atatulukira chidwi cha mankhwalawo, panali mitundu ya meldonium, yomwe imapangidwa ndi LLC Organika, ZAO Binergiya, Solofarm. Chifukwa chake, Mildronate ali ndi mawonekedwe onse a INN analogues - ma generics (meldonium) ndi zojambula zama brand (Angiocardil, Cardionate), omwe ali ndi malangizo ofanana kuti agwiritse ntchito, mitengo yotsika komanso kuwunika kosiyanasiyana.

Koma, monga kale, wotchuka kwambiri ndi "Mildronat" - chitukuko choyambirira cha asayansi aku Latvia. Anali iye yemwe adadziwika padziko lonse lapansi ngati chida chothandiza kwa odwala komanso othamanga, zomwe zimawonjezera kukana kupsinjika, kupilira kwa thupi mpaka kupsinjika, ndikuwongolera kudya kwa myocardium ndi ubongo.

Makhalidwe a mankhwala osokoneza bongo

Mankhwalawa amathandizidwa kuti azichita masewera olimbitsa thupi, azithamanga kwambiri komanso azitha kukumbukira komanso kuti asamalire kwambiri.

Ndi matenda a mtima ndi ischemia, imabwezeretsa kuperekera kwa oxygen m'maselo. Zimawonjezera kugwira ntchito kwa malingaliro ndi thupi, kumachotsa zovuta za kupsinjika kwa malingaliro, kumakhala ndi zotsatira zamtima.

Mankhwalawa amagwiritsidwa ntchito chifukwa cha kulephera kwa mtima komanso mankhwalawa. Kutulutsa Fomu - makapisozi ndi yankho la jakisoni.

Mankhwalawa amathandizanso chitetezo chathupi komanso kukana nkhawa.

Mankhwalawa amafupikitsa kuchira pambuyo pakumwa ischemic, amathandizira kuchepetsa gawo la necrosis.

Mankhwalawa amathandiza kuti achepetse matenda a angina. Amagwiritsidwa ntchito kuti apititse kupirira kuthamanga. Titha kupereka mayankho oyenera ku mayeso obwereza. Mankhwalawa amathandizira kuwonjezera magazi kupita kumalo a ischemia, omwe amafulumizitsa kubwezeretsanso kwa dera lomwe lakhudzidwalo.

Mildronate amathandiza kuchepetsa ziwopsezo za angina.

Mankhwalawa adapangidwa kuti apangidwe ndi matenda omwe amapezeka mu fundus. Mankhwalawa ali ndi mphamvu ya tonic, motero tikulimbikitsidwa kuti mugwiritse ntchito m'mawa. Mankhwalawa amalembera shuga ngati chothandiza.

Kuyerekeza kwa Meldonium ndi Mildronate

Mankhwalawa ali ndi mawonekedwe ofanana komanso omwe amagwira ntchito - meldonium dihydrate. Zisonyezero zakugwiritsa ntchito mankhwalawa:

matenda a mtima
zovuta zamagazi muubongo,
kusiya achire odwala odwala kwambiri uchidakwa,
kupsinjika kwamalingaliro ndi thupi,
matenda am'mbuyo,
kuchira nthawi pambuyo opaleshoni.

Contraindication amakhalanso ofanana kwa onse mankhwala:

kuthamanga kwa magazi
nthawi yoyamwitsa komanso pakati,
ana ochepera zaka 18,
kuchuluka kwachuma kwachuma.

Zotsatira zoyipa za mankhwalawa ndi zofanana:

dyspeptic phenomena
kuchuluka kwa kuthamanga kwa magazi,
kugunda kwa mtima
ziwengo

Wopanga mankhwala onsewa ndi Vidal. Mankhwala sayenera kuphatikizidwa ndi alpha-blockers ndi nitroglycerin. Kupanda kutero, mawonekedwe a tachycardia ndi otheka. Mankhwala onse awiriwa amagwiritsidwa ntchito mosamala mu matenda akulu a impso ndi chiwindi.

Kodi mankhwalawa ndi ofanana bwanji:

zomwe zikugwira ntchito
yemweyo mankhwala
mndandanda womwewo wa zotsutsana ndi zotsatira zoyipa,
kampani imodzi yomweyo.

Kodi Meldonium ndi chiyani? Malangizo, mitengo ndi malingaliro

Munkhani yachipatala iyi, mutha kudziwana ndi mankhwala a Meldonium. Malangizo ogwiritsira ntchito akufotokozera momwe mungamwe mapiritsi ndi jakisoni, zomwe mankhwalawo amathandizira, zomwe zikuwonetsa, magwiritsidwe ndi zotsutsana. Chofotokozedwacho chimapereka mtundu wa mankhwalawa komanso mawonekedwe ake.

Wothandizira anti-arrhythmic wa kalasi la IB, kusintha kagayidwe - kagayidwe kachakudya mthupi la munthu, ndi Meldonium. Malangizo ogwiritsira ntchito akuwonetsa kutenga makapisozi kapena mapiritsi a 250 mg ndi 500 mg, jakisoni m'miyeso ya jakisoni wochizira ngozi zam'magazi, kuchira kwamphamvu mu othamanga, ischemic matenda a mtima.

Zofunika! Meldonium imadziwika ngati dope. Kugwiritsa ntchito pamasewera akatswiri ndi zoletsedwa!

Mankhwala

Metabolism enhancer, gamma-butyrobetaine analogue. Imachepetsa gamma-butyrobetaine hydroxynase, imalepheretsa kaphatikizidwe ka carnitine ndi kayendedwe ka mautali amafuta ambiri kudzera mumitsemvu yama cell, komanso kumalepheretsa kudziunjikira kwamitundu yamafuta aciccarnitine ndi acylcoenzyme A.

Mikhalidwe ya ischemia, imabwezeretsa bwino momwe magwiritsidwe ntchito a mpweya ndikuperekera ma cell, imalepheretsa kuphwanyidwa kwa kayendedwe ka ATP, ndipo nthawi yomweyo imayambitsa glycolysis, yomwe imachitika popanda kugwiritsa ntchito mpweya.

Zotsatira zakuchepa kwa ndende ya carnitine, gamma-butyrobetaine yokhala ndi masodilating amapangidwe kwambiri. Limagwirira ntchito limazindikira kusiyanasiyana kwake zotsatira zake zamankhwala: kuwonjezeka kwa mphamvu, kuchepetsa mphamvu ya kupsinjika kwa malingaliro ndi thupi, kutseguka kwa minofu ndi kusakhazikika pakulimbitsa thupi, mtima.

Kugwiritsa ntchito bwino

Pankhani ya kuwonongeka kwa pachimake kwa ischemic ku myocardium, kumachepetsa mapangidwe a necrotic zone ndikufupikitsa nthawi yokonzanso. Ndi kulephera kwa mtima, kumawonjezera kuchepa kwa mtima, kumathandizira kulolerana, komanso kumachepetsa pafupipafupi matenda a angina.

Mu pachimake komanso matenda a ischemic matenda amitsempha yamagazi amatulutsa magazi mozungulira ischemia, amathandizira kugawa magazi mokomera dera la ischemic. Kugwiritsa kwa mtima ndi dystrophic matenda a fundus.

Imakhala ndi kukhudzika kwa chapakati mantha dongosolo, amachotsa magwiridwe antchito a mantha amthupi mwa odwala omwe ali ndi uchidakwa woperewera.

Malangizo ogwiritsira ntchito

Meldonium imalimbikitsidwa kuti itengedwe m'mawa, chifukwa imatha kupanga zosangalatsa. Mlingo umayikidwa payekha kutengera zisonyezo ndi njira yoyendetsera.

Mukamwa, pakamwa limodzi ndi 0,25-1 g, kuchuluka kwa kayendetsedwe kake komanso nthawi yayitali ya chithandizo kumatengera zomwe akuwonetsa.

0,5 ml ya jekeseni yankho ndi kuchuluka kwa 500 mg / 5 ml kutumikiridwa parabulbarly kwa masiku 10.

Ndi mtsempha wa magazi makonzedwe, mlingo ndi 0,5-1 g 1 nthawi patsiku, nthawi ya mankhwala zimatengera zikuwonetsa.

Ochita masewera amapatsidwa chithandizo chobwezeretsa malingana ndi njira zapadera kuphatikiza ndi njira zina. Odziwika mwapadera ngati dope.

Momwe mungatengere ndi matenda?

Ngati kufalikira kwa matenda a ubongo, Meldonium imalimbikitsidwa nthawi yochulukirapo ya 0,5 g kamodzi patsiku kwa masiku 10, kenako osungidwa - 0,5 g tsiku lililonse kwa masiku 14 mpaka 14.
Mu mtundu wa ngozi ya ubongo. Njira yothetsera jakisoni imaperekedwa intramuscularly pa 0,5 g kamodzi patsiku kapena kutumikiridwa pakamwa pa 0,25 g (pafupipafupi makonzedwe amatengera kuuma kwa mkhalidwe wa wodwalayo).
Kuchotsa matenda kumafuna njira yochizira ndi Meldonium kwa masiku 7-10. Kenako wodwalayo akuwonetsedwa kumwa kwa mankhwalawa kwa nthawi yayitali, 0,5 g mkati kapena nthawi ziwiri.
Ndi khola la angina pectoris, masiku oyamba atatu a 3 ndi 3 ali 3,5 ga katatu. Kenako amatengedwa pakamwa kawiri pa sabata pa tsiku la 0,25 ga katatu. Kutalika kwa mankhwalawa ndikuchokera ku milungu 4 mpaka 6.
Ndi Cardialgia, kuphatikiza ndi dishormonal myocardial dystrophy, mankhwalawa amathandizidwa kudzera m'njira ya jet kamodzi patsiku, 0,5-1 g kapena IM mpaka 2 pa tsiku, 0,5 g patatha masiku 10 mpaka 14, mawonekedwe a kapisozi adayikidwa 0.25 mg m'mawa ndi madzulo, chithandizo chimapitilizidwa kwa masiku ena 12.
Ndi mawonekedwe osasunthika a angina pectoris ndi infrction ya myocardial, Meldonium imagwiritsidwa ntchito kudzera m'mitsempha ya ndege ya 0,5 g kapena 1 g kamodzi patsiku. Pambuyo pake, amalembedwa pakamwa: masiku 3-4 - 0,25 ga 2 kawiri, ndiye masiku 2 pa sabata 0,25 g katatu pa tsiku.
Pankhani ya mtima matenda a fundus, retinal dystrophy, Meldonium ndi zotchulidwa retrobulbarly ndi subconjunctively pa 0,05 g pakapita masiku 10.
Matenda osalephera a mtima, mankhwalawa amaperekedwa mu jet tsiku lililonse pamankhwala a 0,5-1 g kapena m'malo ndi jakisoni wambiri wa 0,5 g mpaka 2 pa tsiku. Pambuyo masiku 10-14 chithandizo, wodwalayo amasamutsidwa 0,5 g makapu, omwe amatenga nthawi 1 m'mawa. Njira ya mankhwalawa imachokera ku milungu 4 mpaka 6.

Werengani komanso nkhaniyi: Ademethionine

Ana pa mimba ndi mkaka wa m`mawere

Meldonium sinafotokozeredwe kwa amayi apakati, chifukwa sizinali zotheka kutsimikizira chitetezo chake kwa mayi ndi mwana. Ngati mukufunikira kupereka mankhwala kwa mayi woyamwitsa, ndiye panthawi ya chithandizo, kuyamwitsa kumayimitsidwa: sizikudziwika ngati chinthucho chimalowa mkaka.

Mwa ana ndi achinyamata ochepera zaka 18, kugwiritsa ntchito bwino kwa meldonium sikunakhazikitsidwe. Meldonium mu mawonekedwe a makapisozi amatsutsana kuti agwiritsidwe ntchito mwa ana ndi achinyamata osakwana zaka 18, mu mawonekedwe a madzi ana osakwana zaka 12.

Kupanga ndi mawonekedwe a kumasulidwa

Meldonium imapezeka m'mitundu ingapo nthawi imodzi: ma ampoules a jakisoni ndi kapisozi kamilomo pakamwa. Meldonium imatha kumasulidwa mu Mlingo iwiri - 250 mg ndi 500 mg. Kutengera mlingo, mtundu wa kapisozi pawokha ukusintha: kuchokera koyera mpaka mlingo wa 250 mg mpaka woyera ndi wachikasu 500 mg. Ampoules amapangidwa mwa kuchuluka kwa 5 ml, 5 kapena 10 ampoules phukusi lililonse.

Potengera kapangidwe kake, awa ndi mankhwala amodzi. Chofunikira chomwe chili ndi mphamvu ndi meldonium dihydrate. Othandizira, kumbali inayo, amadalira mtundu wake wa mankhwalawo. Ampoules amakhala ndi madzi a jakisoni yekha, ndipo makapisozi, gelatin, wowuma, calcium yotsekemera ndi zinthu zina zopanda mankhwala azikhala alendo.

Kodi Meldonium amachita bwanji?

Kwenikweni, Meldonium ndendende mankhwala osokoneza bongo. Zimawonjezera kagayidwe kamtima, ndikuonjezera kukwera kwake ndi okosijeni, komanso zimathandizira pakukula kwa zakudya. Zimathandizanso kutembenuka kwa mitundu yogwira yamafuta acid kukhala mphamvu. Zonsezi mwanjira yabwino zimathandizira kulimbikitsa thupi mu matenda a mtima, komanso zimathandizira kagayidwe kazinthu.

Zotsatira zake, mankhwalawa amathandizira kukulitsa zochitika, mthupi ndi m'maganizo, komanso zimathandizira kugwira ntchito kwa thupi lonse. Chifukwa cha zomwe Meldonium ikuchita pathupi, mtima umayamba kugwira ntchito mokwanira, ndipo metabolism imakhala yolimba kwambiri. Kuphatikiza apo, pali umboni wa zotsatira zabwino za mankhwalawa pamitsempha yamagetsi, ndipo zotulukapo zake zimakhala zabwino kwambiri pambali yothetsa kapena kuchepetsa vuto lochotsa mowa.

Zizindikiro zogwiritsidwa ntchito

Milandu yambiri yomwe Meldonium akuwonetsedwa ndi mayiko osiyanasiyana am'maganizo komanso mwamphamvu thupi, makamaka imatsatana ndi katundu wambiri paminyewa yamtima. Komanso, Meldonium ndi mankhwala omwe amathandizanso kuchira pambuyo pophunzira mwakhama komanso matenda omwe amatsutsana ndi kufalikira kwa matenda a chithokomiro (mndandandawu umaphatikizapo, mwachitsanzo, stroko).

Zofunika! Kumbukirani kuti mankhwalawa amadziwika kuti ndi dope ndipo sangathe kugwiritsidwa ntchito pophunzitsa akatswiri othamanga.

Matenda ndi zizindikiro zomwe mankhwalawa angafotokozedwe ndi izi:

Mavuto ndi matenda a mtima (CHD, kulephera kwa mtima). Meldonium ikhoza kugwiritsidwa ntchito ngati othandizira, komanso mankhwala a prophylactic popewa chiopsezo cha myocardial infarction.
Zosokoneza magazi muubongo: cerebrovascular insufficiency and stroke.
Kuchulukana kwa thupi komanso kwamanjenje.
Monga njira yochitira maphunziro okonzanso.
Mowa kusiya matenda.
Zovuta zomwe zimakhudzana ndi kutopa kwambiri, kuchepa kwa magwiridwe antchito,
Nthawi zina, Meldonium imatha kusintha magazi m'magazi a retina, imagwiritsidwanso ntchito pochiza hemophthalmus.

Payokha, ziyenera kunenedwa kuti mankhwalawa amagwiritsidwa ntchito kokha kwa odwala akuluakulu, kwa ana osaposa zaka 18, mankhwalawa amatsutsana. Izi ndichifukwa chakusowa kwa chidziwitso chachipatala chodalirika pa chitetezo chake kwa achinyamata achinyamata.

Gwiritsani ntchito ana

M'badwo wa ana ndichidziwikire kuti mumamwa mankhwalawo. Izi ndichifukwa choti kafukufuku wokhudza momwe Meldonium amakhudzira thupi la mwana sanachitike, zomwe zikutanthauza kuti palibe chidziwitso chachipatala pankhaniyi. Kuphatikiza ndikuti thunthu limapangidwa ndi mankhwala, izi zimatha kubweretsa mavuto mthupi la ana. Ngati pakufunika mankhwala ochiritsira mwana, mankhwala ena ayenera kusankhidwa.

Pa mimba ndi mkaka wa m`mawere

Iyenera kufotokozera padera tanthauzo la mankhwalawo. Njira yokhayo yomwe Meldonium imaloledwa ndikofunikira kwambiri pokhapokha ngati ndi nthawi yokhayo yomwe amayi adasiya kuyamwitsa. Komabe, ngakhale pakadali pano, sikuyenera kungoyanjanitsidwa ndi katswiri, komanso kuwunikira mosamala mkhalidwe wa mkaziyo nthawi yonse yomwe akumwa mankhwalawo. Ngati mzimayi ali ndi zovuta zilizonse zosafunikira, muyenera kusiya kumwa ndi kufunsa dokotala.

Kuyenderana ndi mowa

Mankhwalawa amachotsedwa m'magazi patatha pafupifupi maola 12 atagwiritsidwa ntchito komaliza, zomwe zikutanthauza kuti mpaka pano kumwa mowa kwambiri kungayambitse kuyanjana ndi mankhwalawa. Komabe, kwakukulu, mowa ndi Meldonium sizigwirizana. Ngakhale pali chidziwitso chakuti zakumwa zoledzeretsa mu mitsempha ndi m'magazi zimatha kusokoneza zotsatira za kumwa mankhwalawa, zomwe zimapangitsa kuti mankhwalawa asapindule. Kuphatikiza apo, ziyenera kumvetsedwa kuti ngati Meldonium adayikidwa ngati chithandizo chothandizira matenda a mtima, zakumwa zoledzeretsa siziyenera kuphatikizidwa kuti zigwiritsidwe ntchito konse. Kulandilidwa kwa iwo mwanjira iyi sikungangopeputsa kudya kwa mankhwalawo, komanso kungawononge mtima ndi minofu ya mtima.

Kuchita

Pogwiritsa ntchito munthawi yomweyo Nitroglycerin, alpha-blockers, Nifedipine, zotumphukira vasodilators, pali mwayi wa tachycardia ndi ochepa hypotension. Imawonjezera ntchito ya antihypertensive, antianginal mankhwala, mtima glycosides.

Mwina kuphatikiza ndi antianginal mankhwala, anticoagulants, antiarrhythmic mankhwala ndi okodzetsa.

Zofunika! Osagwiritsa ntchito nthawi yomweyo limodzi ndi mankhwala ena okhala ndi meldonium.

Maholide ndi mtengo

Mtengo wamba wa Meldonium (jakisoni a 5 ml No. 10) ku Moscow ndi 145 rubles. Ku Ukraine, mutha kugula mankhwala a 195 hryvnia. ku Kazakhstan, malo ogulitsa mankhwala amapereka analogue of Mildronate. Ku Minsk, amagulitsa mankhwalawa kwa ma 4-6. ma ruble. Kuti mupeze mankhwalawa, muyenera kulandira mankhwala.

Potsatira maulalo, mutha kudziwa kuti ndi ma analogu ati omwe amagwiritsidwa ntchito pochiza matenda: kusiya, kuledzera, hemophthalmus, dishormonal cardiomyopathy, stroke, myocardial infarction, hemorrhage, angina pectoris, thrombosis, kupsinjika kwa thupi, kuperewera kwa mtima, kuperewera kwa mitsempha

Mildronate - momwe angatengere othamanga

Meldonium idapezeka mu 70s ya zaka za zana la 20 ku Latvia Institute of Organic Synthesis ndipo poyambirira idagwiritsidwa ntchito monga othandizira pakukula kwa mbewu ndi ziweto, ndipo pambuyo pake idayamba kugwiritsidwa ntchito kumalo azachipatala. Popita nthawi, madotolo adayamba kupereka mankhwala kwa matenda osiyanasiyana monga othandizira kagayidwe kake ndikuwalimbikitsa kuti osewera azitha kuchira.

Chifukwa chiyani meldonium imafunikira pamasewera

Kodiofiyoni ndi chiyani, ndipo angatengedwe ndi amateurs? Thupi limakhala ngati analogue ya gamma-butyrobetaine - enzyme yomwe imapezeka mu khungu lililonse laanthu.

Limagwirira a zochita za mankhwala. Meldonium imalepheretsa kupanga carnitine m'thupi ndipo imachepetsa kugwiritsa ntchito mafuta achilengedwe ngati mphamvu. Nthawi zambiri zimakhala mafuta omwe amawonongeka pomwe mphamvu zimagwiritsidwa ntchito ndi anthu omwe amakhala moyo wokangalika.

Ndipo mafuta acids amasinthidwa kukhala mphamvu m'minyewa ya mtima, yomwe imapangitsa mtima kugwira ntchito mwachangu. Kuchita kwa minimronate ndikumanganso ndikusintha ndikupanga mphamvu kuchokera ku glucose ndi oxygen. Izi zimachepetsa nkhawa pamtima ndi ziwalo zina zofunika.

Pazochita zake, mankhwalawo ndi osiyana ndi zowonjezera monga L-carnitine.

Cholinga chachikulu cha Mildronate ndi kukonza kagayidwe kazachilengedwe ndi mphamvu pama cellular.

Zothandiza meldonium pamasewera

Imathandizira kuchira pambuyo polimbitsa thupi. Katunduyu ndiwofunika pamasewera aliwonse, mu masewera olimbitsa thupi akhoza kukhala masewera awiri ndi Cardio komanso mphamvu. Zinthu zowola zimatulutsidwa msanga m'maselo, ndipo njira zochira zimapitilira modabwitsa. Zotsatira zake, wothamanga amatha kuphunzitsa pafupipafupi komanso mwaluso.
Kumapangitsa kuti thupi lizichita mantha komanso kugwira ntchito zolimbitsa thupi. Izi zokhala ndi zonyezimira zimakhala zothandiza kwambiri pakampikisano kapena pakuuma, pomwe zinthu zonse zamthupi zimatha.
Kuchita kwathunthu kumawonjezera ndipo kuchuluka kwake kumawonjezeka.Wothamanga amakhala wokalamba, wamphamvu, amawonjezera kuyenda komanso kuchuluka kwa nkhawa.
Imathandizira kayendedwe ka glucose kupita ku maselo ndikuteteza mtima ku arrhythmias, angina pectoris. Uku ndiko kupewa matenda owopsa amtima monga kugunda mtima kapena sitiroko.
Zothandiza kwa asthenia. Kumwa mankhwalawa kumakuthandizani kuti muchotse matenda a kutopa kwambiri, kugona ndi kufooka. Zonsezi, zachidziwikire, zimakhala ndi zotsatira zabwino pazotsatira zamasewera.

Meldonium ikhoza kugwiritsidwa ntchito pamtundu uliwonse wa katundu mu masewera olimbitsa thupi. Komabe, simuyenera kuyembekezera mutatenga kukula kwa zizindikiro ndi mphamvu yayitali ya minofu. Mankhwalawa samakhudza kukula kwa minofu mwanjira iliyonse, ndipo ngati kuwonjezeka kwa mphamvu kukuwonekera, ndiye kuti ndi kochepa.

Pa gawo la phindu lochulukirapo ndikuwonjezera mphamvu, ndikofunikira kugwiritsa ntchito meldonium kokha kuti mubwezeretse ndikuwonjezera mphamvu ya thupi.

Mildronate imakhala yothandiza kwambiri panthawi yayitali yochita masewera olimbitsa thupi. Amawonetsedwa othamanga, osewera mpira, oyendetsa skiers kuti apirire bwino komanso kusintha kamvekedwe ka mtima. Chimateteza othamanga kuti asalembe kwambiri.

Aliyense amadziwa milandu pomwe othamanga amakomoka pomwe pamasewerawa, popeza thupi silingathe kupirira chifukwa cha kuchuluka kwambiri.

Kugwiritsidwa ntchito kwa meldonium kumapewetsa mavuto ena mthupi.

Ngati mumadya kwambiri koma mukuphunzitsa, ndiye kuti kutenga Mildronate kumathandizanso. Chifukwa cha kagayidwe kachakudya kam'ma cell, kagayidwe kamachulukidwe ndikuwonjezereka.

Komabe, ndikofunikira kudziwa kuti sikofunikira kuphatikiza meldonium ndi mafuta ambiri, komanso zakudya zopanda mafuta a carbohydrate.

Gwero lalikulu lamphamvu mukamamwa Mildronate ndi glucose, chifukwa chake simuyenera kuchepetsa kuchuluka kwa zopatsa mphamvu komanso zovuta kuzimitsa, ngakhale mutayanika.

Zomwe meldonium imawerengedwa kuti ndiyopendekera

Mu Januwale 2016, Mildronate adaphatikizidwa pamndandanda wa mankhwala oletsedwa ndipo tsopano akuwoneka kuti ndi doping. Panthawiyo, kunamveka chiphokoso ndi osewera achi Russia omwe akhala akugwiritsa ntchito mankhwala osiyanasiyana kwa nthawi yayitali.

Chisangalalo chotere chidasewera m'manja mwa opanga meldonium, popeza malonda ogulitsa adakwera kwambiri. Lero, funso la zomwe zimafunikira kwa owonda sakhazikitsa akatswiri osati okhawo omwe amagwira ntchito zamasewera, komanso alendo wamba ochita masewera olimbitsa thupi.

Mpaka pano, madokotala ambiri samvetsa chifukwa chomwe meldonium imatchulira doping. Kupatula apo, adapangidwa kuti azithandizira thanzi komanso kusateteza, pakalibe kuyankhula za kuwonjezeka kwakukulu kwa kuthekera kwakuthupi.

Mtundu waukulu wakuletsedwa kwa Mildronate ndi mphamvu yake pa magwiridwe antchito a anthu, kuwonjezeka kwamphamvu komanso kopatsa chidwi.

Chifukwa cha izi, wothamanga yemwe akutenga Mildronate amakhala ndi mwayi mu mpikisano.

Ngati mumachita nokha, musawope kugwiritsa ntchito mankhwalawa. Kutengera ndi chizolowezi, ndizotetezeka kwa thupi. Koma kwa osewera omwe amapikisana ndikupereka magazi kuti ayesere kuyesa, ndibwino kusiya meldonium kapena kugwiritsa ntchito kalekale zisanachitike.

Kugwiritsira ntchito mankhwala ngati mankhwala

Kuwonekera kosiyanasiyana kwa mankhwalawa kumapangitsa kuti ikhale yothandiza m'matenda osiyanasiyana. Mildronate amalembera mavuto otsatirawa:

Matenda a bronchitis, mphumu ndi zina za ziwalo zopumira zomwe zimayenderana ndi kuperewera kwa mpweya,
Kuphatikiza mankhwala a matenda a mtima - angina pectoris, kulowetsedwa kwamtima, mtima kulephera,
Ngozi zapamsewu,
Kupsinjika kwa nthawi yayitali komanso kutopa,
Ngati mankhwala a hangover pachimake ndi uchidakwa matenda,
Matenda amaso omwe amayambitsidwa ndi vuto lamagazi a retinal,
Mitundu ina ya matenda a shuga.
Nthawi yogwira ntchito kuti ichiritse ntchito mwachangu.

Ngakhale kuchuluka kwazinthu zabwino, meldonium, monga mankhwala aliwonse, ali ndi malire. Sichikulimbikitsidwa kuti chikhale ndi ana osaposa zaka 18, nthawi yomwe muli ndi pakati, ndimavulala a craniocerebral, vuto la venous kubuda, impso, chiwindi, ndi mavuto amanjenje. Kutsatira makonzedwe, zotsatirazi zoyipa ndizotheka:

Kutsitsa magazi
Kuchuluka kwa mtima,
Hyperacaction.

Pofuna kupewa zovuta, tikulimbikitsidwa kugwiritsa ntchito Mildronate m'mawa osapitilira muyeso. Nthawi zina, sayanjana zimachitika, komanso kutentha kwa mtima, nseru pambuyo.

Momwe mungatengere meldonium kwa othamanga

Mankhwalawa amaperekedwa mu mawonekedwe a makapisozi, mapiritsi ndi madzi, omwe cholinga chake ndi pakamwa. Palinso njira yothetsera vutoli yomwe imatha kutumikiridwa kudzera m'mitsempha kapena intramuscularly.

Momwe mungatenge Mildronate kuti othamanga azitha kuchita bwino kwambiri? Inde, jakisoni wotsekemera amakhala wachangu kwambiri komanso wothandiza kwambiri.

Komabe, pankhaniyi, ndikofunikira kuyang'anira mosamalitsa ndi kukhala ndi luso la jakisoni, apo ayi zitha kukhala zovulaza thanzi. Ochita masewera a Amateur ndibwino kusankha piritsi ndi kapisozi.

Mukamamwa pakamwa, Mildronate amaledzera m'mawa theka la ola asanadye, kapena mphindi 30 atatha kudya. Mankhwalawa sangathe kuphwanyidwa kapena kutafunidwa, amameza lonse ndikutsukidwa ndi madzi ambiri.

Kuwongolera magwiridwe antchito, tikulimbikitsidwa kutenga meldonium pa 500 mg patsiku, ndiye kuti 250 mg kawiri pa tsiku kapena nthawi 1 patsiku 500 mg. Patsiku la maphunziro, muyenera kutenga zinthuzo theka la ola musanaphunzire.

Mlingo weniweniwo amawerengedwa ndi kulemera - 15-20 mg pa kilogalamu ya thupi. Kugamula komaliza sikuyenera kukhala kosachedwa kuposa 17.00 kapena osapitirira maola 5 asanagone kuti mupewe kuwonjezereka.

Akatswiri amatha kuonjezera kuchuluka kwa mankhwalawa katatu ndipo amamwe mankhwalawa kawiri pa tsiku.

Phukusi loyenera, meldonium imakhala ndi makapisozi 40 a 250 mg. Palinso mitundu ya kapisozi 60 ya 500 mg iliyonse. Mtengo muma pharmacies umasiyana kuchokera ku 230 mpaka 400 ma ruble.

Muthanso kupeza 10% yankho la Mildronate wa jakisoni - ma ampoules 10 a 5 ml. Mbale umodzi uli ndi 500 mg ya meldonium. Ndikofunikira kutsatira malangizo osasokoneza njira yovomerezeka ndi intramuscular.

Mutatsegula ampoule, mankhwalawa amayenera kubayidwa nthawi yomweyo, popeza mankhwalawa salola kuyanjana ndi mpweya kwa mphindi zoposa 5. Mtengo wa phukusi limodzi ndi jakisoni umachokera ku ma ruble 68 mpaka 150. Kutalika kotenga Mildronate ndi masabata 3-5.

Kenako muyenera kupuma kaye kwa mwezi umodzi kuti musazolowere thupi. Pambuyo pake maphunzirowo akhoza kubwerezedwa.

"Mildronate - chimathandiza ndi momwe tingachigwiritsire ntchito?"

Zonsezi zidayamba pa Januware 1 omaliza, 2016. Inali nthawi imeneyi pamene WADA (World Anti-Doping Agency) imabweretsa meldonium, aka Mildronat, mndandanda wazachuma zoletsedwa.

Cholinga chake chinali chakuti cytoprotective ndi metabolic zotsatira zitha (mwina) kusintha myocardium kwambiri kuti mtima ukhale wolimba komanso wolimba kwambiri, zomwe zingapangitse kuti zitheke, motero ndalama zambiri.

Mbiri ya mankhwalawa idaphatikizika.

Inapangidwa koyamba mu Latvia SSR ndi Ivars Kalvins, ndipo poyamba amafuna kuti agwiritse ntchito pochotsa zinthu zakupha za rocket mafuta (dimethylhydrazine).

Koma pophunzira kuopsa kwa mankhwalawa mu nyama, zotulukapo zake zidapezeka kuti kuyambira 1976, mankhwala otchedwa Mildronate adalembedwa ku USSR, kenako ku USA (kuyambira 1984).

Mildronate (meldonium) pamasewera: zowonadi, magwiridwe antchito, momwe angalandirire ndipo ndikoyenera?

Mbiri yakale yofewa (meldonium) pamasewera imayamba ndi wosewera wotchuka wa tennis ku Russia, dzina lake Maria Sharapova. Mu 2016, adakhala nyenyezi yakusokosera kokumbidwa, atayesedwa doping pa Australia Open.

Chifukwa chake sichinali anabolic steroids, erythropoietin kapena mahomoni, koma mankhwala osokoneza bongo a Cardio, modzidzimutsa osati a Sharapova okha, koma gulu lonse la padziko lonse lapansi komanso ngakhale osewera omwe amakhala mwamphamvu pa pharmacology.

Munkhaniyi tikambirana zowona zokhuza zonenepa, kudziwa cholinga chake, zamankhwala, komanso zomwe zingachitike.

Zambiri pa Mildronate (Meldonium)

Meldonium idapangidwa ndi kampani yopanga mankhwala yaku Latvia
Meldonium ndi choletsa mafuta oxidation (amaletsa kuyaka kwawo)
Kugwiritsira ntchito masewera olimbitsa thupi mopepuka kumaletsedwa ndi World Anti-Doping Agency (WADA)
Chizindikiro chachikulu chogwiritsidwa ntchito ndi mankhwala osakaniza ndi chithandizo cha mavuto a mtima, koma mndandanda wazidziwitso ndiwofalikira kwambiri
Meldonium ndi yoletsedwa kugwiritsidwa ntchito (yopanda chilolezo) ku United States, imaloledwa ku Russia ndi maiko ena omwe kale anali USSR bloc
Mankhwalawa anali kugwiritsidwa ntchito kwambiri ndi asitikali aku Soviet Union pankhondo ku Afghanistan.

Kodi meldonium (modabwitsa) ndi chiani?

Meldonium idapangidwa ndi kampani yopanga mankhwala yaku Latvia Grendiks.

Limodzi mwa malangizo oyamba a Mildronate linali kukonza kuchuluka kwa ubala (umuna) ndi nkhumba zazimuna ndi ziweto zina. Pambuyo pake, kukula kunakulitsidwa kukhala 2.

Kugulitsa mankhwalawa kunakwana ma miliyoni 56 miliyoni mu 2013, zomwe zidapangitsa Grendiks kukhala amodzi mwa ogulitsa kunja pamsika wazachipatala wa ku Latvia.
Kuyambira 1979 mpaka 1989, Mildronat adapereka "kuyesa" kwakukulu kwa asitikali aku Russia: adatumizidwa ku Afghanistan kuchokera ku 1979 mpaka 1989.
Chifukwa chiyani?
Malinga ndi wopanga mapulogalamu a Ivan Calvins, momwe meldonium imathandizira ndikupereka kwa mpweya m'thupi.
Asitikali adatenga meldonium pomwe ali kumapiri a Afghanistan, pomwe kunali kofunikira kunyamula zida zolemetsa: mankhwalawa adasintha chipiriro m'malo opumira mpweya.

Masiku ano, Mildronate ndi mankhwala omwe amagwiritsidwa ntchito ku Eastern Europe ndi Central Asia (mayiko omwe kale anali Soviet Union) kuchiza matenda ambiri, koma koposa zonse matenda amtima. Ku United States ndi mayiko ena ambiri, ndizoletsedwa.

Kuphatikiza pa kugwiritsa ntchito zachipatala, meldonium imagwiritsidwa ntchito kwambiri pamasewera ngati othandizira doping yomwe imasintha magwiridwe antchito.

Kuyambira kuchiyambiyambi kwa chaka cha 2016, pomwe Maria Sharapova adamubweretsera kutchuka, osewera ambiri ochokera kumayiko osiyanasiyana (kuphatikiza USA, Russia ndi mayiko aku Europe) adalembedwa ndi WADA kuti igwiritse ntchito.

Meldonium ndi mankhwala omwe cholinga chawo choyambirira chinali kuwonjezera kuchuluka kwa nkhumba. Masiku ano amagwiritsidwa ntchito kwambiri pochiza matenda amtima.

Chifukwa chiyani Mildronate adalembedwa ngati mankhwala?

Mankhwala, Mildronate amalembedwa kwa odwala omwe ataya magazi m'zigawo zina za thupi, makamaka, omwe ali ndi mavuto amtima komanso matenda amitsempha yamagazi (omwe amachepetsa mtima weniweni), pochiza matenda a angina ndi mtima.

Kafukufuku wa sayansi akutsimikizira kutha kwake pochiza matenda a mtima osalephera 4 ndi stroke 5.

M'mayiko ena, kuphatikiza Russia, Latvia, Ukraine, Georgia, Kazakhstan, Azerbaijan, Belarus, Uzbekistan, Moldova, ndi Kyrgyzstan, madokotala amathandizira kuti magazi azikhala ndi magazi ambiri.

Zawonetsedwa kuti zimathandizira kusintha kwa mawonekedwe ndikuwongolera ntchito yamagalimoto, zimachotsa chizungulire ndi mseru 8.

Komanso meldonium Imathandizanso kuona matenda osokoneza bongo atamwa mowa.

Zizindikiro zina pakugwiritsa ntchito Mildronate 6:

zilonda zam'mimba
kuvulala kwamaso
matenda am'mapapo ndi kupuma.

Ngati muwerenga mosamala malangizo ogwiritsira ntchito moduladula, tidzaona kuti mapangidwe ake "akukonzanso zolimbitsa thupi", ngakhale gawo loti "silikuwoneka ndi masewerawa" lipezekanso pamenepo.

Pali chisokonezo, chifukwa zikuwonekeratu kuti chilichonse chomwe chimasintha magazi, chimakhala bwino. Zochita zakukonzekera doping yambiri ndizokhazikika pam mfundo iyi.

Malongosoledwe a WADA chifukwa chowonjezera meldonium pamndandanda wa mankhwala osokoneza bongo oletsa kuthamangitsidwa akuyang'ana kwambiri malowa: "meldonium imawonjezera kusewera pamasewera popereka mpweya ku minofu ndi minyewa."

Mankhwala, Mildronate adalembedwa kuti azithandiza magazi kupitilira ziwalo zosiyanasiyana, kuphatikizapo mtima ndi ubongo, komanso kuthana ndi zizindikiro za khomalo atamwa.

Mildronate (Meldonium) pamasewera

Kutchuka kwa Mildronate pamasewera kunabweretsedwa ndi wosewera wa tennis waku Russia a Maria Sharapova, yemwe sanapereke ulamulirowu pa March 2016, miyezi itatu kuchokera pamene meldonium idalembedwa ndi WADA 1.

Adavomereza kuti adagwiritsa ntchito mankhwalawo kwa zaka 10 monga adalamulira adokotala. Onani kuwunika kwa mtima wama mtima pazakugwiritsa ntchito kwa meldonium Sharapova.

Atazindikira izi, malonda a Mildronate adakula kangapo.
Pafupifupi nthawi yomweyo ndi chiletso cha Sharapova, WADA idalandira skater Ekaterina Bobrova waku Russia ndipo chaka chomwecho, wopikisana padziko lonse lapansi mu 1500 m akuthamanga Abeba Aregawi, wopambana pa mpikisano wa Tokyo mu 2015 Endeshaw Negesse.
Ma medali 13 a Masewera a ku Europe ku Baku mchaka cha 2015 nawonso adawonetsa kuyesa kogwiritsa ntchito meldonium, ndipo akatswiri adati panthawi yawo akuchita, pafupifupi 470 onse omwe adamwa mankhwalawo adatenga 17.
Kuyambira nthawi imeneyi, geography yatukuka kwambiri, ndipo othamanga ku Russia, Ethiopia, Sweden, Germany ndi Ukraine agwidwa nthawi zosiyanasiyana pogwiritsa ntchito meldonium.

Zikuyenera 17% ya othamanga ku Russia amagwiritsa ntchito meldonium ndi 2% okha m'maiko ena. Ngati nambalayo ndi yolondola, ndiye kuti izi zikutsimikiza.

Nkhani yomwe yachitika posachedwa komanso kuletsa kutenga nawo mbali kwa magulu onse aku Russia ku Olimpiki kukuwonetsa kuti msika wa Russia, womwe umathandizira masewera aluso, ndi amodzi mwamphamvu kwambiri komanso otukuka padziko lapansi.

Mildronate adatchuka mu masewera makamaka chifukwa cha dzina la wosewera wa tennis waku Russia Maria Sharapova: atadziwika, kugulitsa mankhwalawa kunawonjezeka kangapo

Malinga ndi gulu la WADA, meldonium ndi ya gulu la metabolic modulators, kuphatikiza insulin 7.

Ngati mukuwona kuti ndizofunikira - tithandizire ntchito yathu!

Zowonjezera. Thupi limaphatikizidwa ndi pepala lolemba ngati:

Amachita bwino masewera othamanga,
Iwopseza othamanga,
amaphwanya mzimu wopikisana.

Tanthauzo la chitsimikiziro choyamba ndikowonekera: othamanga omwe amamwa mankhwalawa amapeza zabwino kuposa ena. Chitsimikizo chachiwiri chimagwira ntchito pafupifupi mankhwala aliwonse azachipatala, chifukwa onse ali ndi mavuto. Koma tanthauzo la lachitatu ndilamphamvu kwambiri ndipo limakupatsani mwayi woletsa "kuletsa" chilichonse.

"Meldonium akuwonetsa kukonza osewera opirira, mitengo yobwezeretsa pambuyo pa kulipira, anti-nkhawa chitetezo ndi dongosolo lamanjenje limapangitsa chidwi. ”

Mndandanda wapadera wazotsatira za meldonium mu masewera ndi zina monga izi:

zimawonjezera kuchita kwathunthu kwakuthupi,
Amapangitsa kuti mpweya uzitulutsa,
imathandizira kusangalala kwa minofu yamitsempha (izi ndizofunikira kuti kuthamanga kuzichite),
imathandizira polimbana ndi kupsinjika kwa malingaliro pa mipikisano,
Amathandizira pakupezeka kwa maselo a mtima ndi ubongo ndi glucose = mphamvu,
imathandizira kuchotsedwa kwa zinthu zowonongeka.

Zomwe zimachitika potenga Mildronate, komwe ndikofunikira kwa othamanga, ndikupititsa patsogolo kupezeka kwa minofu ndi mpweya ndi glucose, kukulitsa zomwe zimachitika komanso kuthana ndi nkhawa

Limagwirira zake meldonium

Zotsatira zakuchiritsa kwa meldonium ndizo Kuletsa machitidwe a carnitine, yomwe imakhudzidwa ndi kagayidwe ka mafuta (kuwawotcha mphamvu), pakugwiritsa ntchito shuga 3.
Mukamachita masewera olimbitsa thupi (omwe amawononga mpweya wambiri), L-carnitine imathandizira kugwira ntchito kwa mtima, ndikupanga mafuta oxidation ogwira ntchito mwamphamvu kwambiri: pafupifupi 80% ya mphamvu imapangidwa pogwiritsa ntchito makina 10 awa.
Komabe, m'malo omwe mulibe okosijeni okwanira m'maselo, zinthu zapoizoni zimadziunjikira - zopangidwa ndi mafuta oxidation.
Zomwe zimapangitsa meldonium: imalepheretsa makina a mafuta oxidation ndi carnitine (kuchepetsa kuchuluka kwake m'maselo) ndikuyambitsa kugwiritsa ntchito shuga, komwe ndiko gwero lamphamvu kwambiri komanso lothandiza kwambiri mthupi, popeza limafunikira mpweya wambiri 11-13 kuti uziphatikiza.
Kuphatikiza apo, Mildronate imathandizira mwachindunji glycolysis, yomwe imakulitsa mphamvu ya wothamanga mphamvu 14.

Kodi ndizomveka kuti titengere khungu (meldonium) pomanga thupi?

Meldonium ndiyotchuka kwambiri m'masewera aerobic, mwachitsanzo, pakati pa osewera ndi othamanga omwe kuthamanga ndi kuchitapo kanthu ndikofunikira.
Pankhani yogwiritsa ntchito kufatsa pomanga thupi ndikukhala mphamvu, Mosiyana ndi zomwe ambiri amakhulupirira, iye Sizimakhudza mwachindunji kukula kwa minofu.
M'masewera agetsi imagwiritsidwa ntchito. kuchepetsa zizolowezi zobwereza, zomwe mwina ndizofunikira kwa akatswiri othamanga.

Werengani ife pa ukonde

Zomwe zili bwino: chepetsa katunduyo kapena onjezerani piritsi lina ku mankhwala anu opanga mankhwala - mwasankha.

Mildronate pomanga thupi sizimakhudza mwachangu kukula kwa minofu, amagwiritsidwa ntchito kuthana ndi zizindikiro zopitilira muyeso

Momwe mungatengere Mildronate othamanga: malangizo

Chizindikiro cha kutenga meldonium mumasewera ndi chikhalidwe chambiri chambiri.

M'maphunziro asayansi omwe amawonetsa zotsatira zabwino za kufewa kwa akatswiri othamanga, Mlingo wa 0.25-1 g kawiri pa tsiku nthawi zambiri amagwiritsidwa ntchito kwa masabata 2-3 a nthawi yophunzitsira, masiku 10 mpaka 14 mpikisano usanachitike.

Mukalandira kwambiri Mlingo woyenera ndi wofunikira. Mlingo watsiku ndi tsiku amawerengedwa potengera 15-20 mg pa kilogalamu ya thupi.

Meldonium pamasewera (ndi zomanga thupi) amavomerezedwa 1 nthawi patsiku 30 asanaphunzitsidwe.

Nditha kutenga Mildronate mpaka pati?

Kutalika kwa maphunzirowa ndi kuyambira pa masabata 6 mpaka miyezi itatu. Pambuyo pake, thupi limayamba kugwiritsa ntchito mankhwala osokoneza bongo, limatha mphamvu. Pambuyo pakupuma kwa milungu 4, chiwopsezo chimabwezeretseka.

Meldonium imatha kumwedwa m'mitundu iwiri: mapiritsi ndi jakisoni. Mwanjira ya mapiritsi, tsiku lililonse mlingo sayenera kupitirira 2 g. Zingwe ndizothandiza pafupifupi kawiri.

Mildronate nthawi zina amalimbikitsidwa pamodzi ndi L-carnitine ndi Riboxin. Poyambirira, pali kusamveka, popeza momwe limagwirira ntchito laofronite ndikutchingira zochita za carnitine.

Meldonium pamasewera ndi masewera olimbitsa thupi amatengedwa pamlingo wa 15-20 mg pa kg iliyonse ya thupi 1 nthawi isanaphunzitsidwe

Kodi meldonium imakhala nthawi yayitali bwanji?

Palibe yankho losatsutsika kufunso lokhudza nthawi yakuchotsa meldonium m'thupi, popeza sizinaphunzitsidwe ndi asayansi.
Olemba ena akuti nthawi yodzipatula nthawi yayitali Maola 24 ndi kumwa kamodzi, ngati atengedwa pafupipafupi, ndiye kuti kupezeka m'magazi kungatheke ngakhale pambuyo pake miyezi ingapo atasiya kugwiritsa ntchito.
Akatswiri ena amati kuchotsedwa kwathunthu kwa kufewa kwa thupi kumachitika m'masiku 100-120.

Nthawi yonse yochotsa meldonium m'thupi imatha kufika miyezi 3-4 ndikugwiritsa ntchito pafupipafupi

Mildronate: mavuto

Kafukufuku yemwe alipo palibe mavuto akulu meldonium.

Komabe, malinga ndi ndemanga za akatswiri a mtima, madokotala amawona kuti nkhaniyi siimamveka bwino.

Zotsatira zoyipa zimasonyezedwa mu malangizo ogwiritsira ntchito modekha:

chifuwa
tachycardia (kuchuluka kwa mtima),
kugaya chakudya.

Pambuyo pake

Mildronate ndi chipangizo chamakampani opanga doping, omwe othamanga padziko lonse lapansi akufuna kuyesa (chifukwa cha izi kwa Maria Sharapova).

Kugawana ndi kugwiritsa ntchito kothamanga kwa osewera ku Russia kukuwonetsa kuthekera kwake. Kafukufuku wochepa wa asayansi akutsimikizira kugwiritsa ntchito meldonium pamasewera aerobic (kuthamanga, kugwedeza, kupalasa njinga) ndi kuphatikizira mphamvu (zolimbitsa thupi, kupatsa mphamvu).

Mildronate amachotsedwa m'thupi kwa miyezi ingapo ndipo alibe zotsatira zoyipa.