Mankhwala Diabinax: malangizo ogwiritsira ntchito

Mapiritsiwo ndi oyera, ozungulira, lathyathyathya, okhala ndi mbali zopindika ndi mzere wolakwika mbali imodzi.

1 tabu
gliclazide	20 mg

PRING microcrystalline cellulose, wowuma, povidone, sodium methylparaben, colloidal silicon dioxide (Aerosil), magnesium stearate, sodium starch glycolate, talc, madzi oyeretsedwa.

Ma PC 10 - matuza (1) - mapaketi a makatoni.
20 ma PC. - matuza (1) - mapaketi a makatoni.

Mapiritsiwo ndi oyera, ozungulira, lathyathyathya, okhala ndi mbali zopindika ndi mzere wolakwika mbali imodzi.

1 tabu
gliclazide	40 mg

PRING microcrystalline cellulose, wowuma, povidone, sodium methylparaben, colloidal silicon dioxide (Aerosil), magnesium stearate, sodium starch glycolate, talc, madzi oyeretsedwa.

Ma PC 10 - matuza (1) - mapaketi a makatoni.
20 ma PC. - matuza (1) - mapaketi a makatoni.

Mapiritsiwo ndi oyera, ozungulira, lathyathyathya, okhala ndi mbali zopindika ndi mzere wolakwika mbali imodzi.

1 tabu
gliclazide	80 mg

PRING microcrystalline cellulose, wowuma, povidone, sodium methylparaben, colloidal silicon dioxide (Aerosil), magnesium stearate, sodium starch glycolate, talc, madzi oyeretsedwa.

Ma PC 10 - matuza (1) - mapaketi a makatoni.
20 ma PC. - matuza (1) - mapaketi a makatoni.
Ma PC 10 - matuza (6) - mapaketi a makatoni.

Zotsatira za pharmacological

Diabinax ndi mankhwala a hypoglycemic omwe amachokera ku m'badwo wa sulfonylurea II. Imapangitsa secretion ya insulin ndi kapamba, imapangitsa insulin-chinsinsi cha glucose, imawonjezera mphamvu ya zotumphukira zimakhala kuti insulin. Imalimbikitsa ntchito ya intracellular michere - minofu glycogen synthetase. Kuchepetsa nthawi kuyambira nthawi yakudya mpaka pakuyamba kwa insulin. Imabwezeretsa chiyambi choyambirira cha insulin secretion (mosiyana ndi zina zomwe zimachokera ku sulfonylurea, mwachitsanzo, glibenclamide ndi chlorpropamide, zomwe zimakhudza makamaka gawo lachiwiri la secretion). Amachepetsa nsonga hyperglycemia atatha kudya.

Kuphatikiza pa kukhudza kagayidwe kazakudya, kumakhudzanso ma microcirculation. Amachepetsa nsonga hyperglycemia atatha kudya. Imachepetsa kupendekera ndi kuphatikiza, imachepetsa kukula kwa khoma. Imasinthasintha kukhathamira kwamitsempha, imalepheretsa kukula kwa microthrombosis, kubwezeretsa njira ya parietal fibrinolysis.

Imachepetsa mphamvu ya mtima ku adrenaline. Amakhala ndi anti-atherogenic katundu, amachepetsa kuchuluka kwa cholesterol yathunthu m'magazi.

Imachedwetsa kukula kwa matenda ashuga retinopathy osachita bwino. Ndi matenda a shuga a nephropathy omwe amagwiritsidwa ntchito kwa nthawi yayitali, pali kuchepa kwakukulu kwa proteinuria.

Siziwonjezera kukwera kwa thupi, chifukwa imakhala ndi mphamvu pakadutsa katemera wa insulin ndipo samayambitsa hyperinsulinemia, imathandizira kuchepetsa kulemera kwa odwala onenepa kwambiri, kutsatira zakudya zoyenera.

Pharmacokinetics

Mukamamwa pakamwa, mankhwalawa amayamwa bwino kwambiri m'mimba. C max m'madzi a m'magazi amafikira pafupifupi maola 4 atatha kumwa kamodzi kwa 80 mg. Kuphatikiza kwa mapuloteni a Plasma ndi 94%. Zimapangidwa m'chiwindi ndikupanga ma metabolites angapo. Amadziwitsidwa ndi impso - 70% mu mawonekedwe a metabolites, ochepera 1% amachotsedwa mu mkodzo, ndowe - 12% mu mawonekedwe a metabolites. T 1/2 - pafupifupi maola 12

Mlingo wa mankhwala DIABINAX

Mlingo wa mankhwalawa umayikidwa payekhapayekha, kutengera zaka za wodwalayo, mawonetseredwe amtundu wa matenda komanso msanga wa kudya glycemia komanso maola awiri atatha kudya. Mlingo woyamba wa tsiku lililonse ndi 80 mg, pafupifupi tsiku lililonse ndi 160 mg, ndipo mlingo waukulu wa tsiku ndi tsiku ndi 320 mg. Diabinax amatengedwa pakamwa 2 nthawi / tsiku (m'mawa ndi madzulo) mphindi 30-60 asanadye.

Kuyanjana kwa mankhwala osokoneza bongo

Sulfanilamides, salicylates, anticoagulants osadziwika, anabolic steroids, beta-blockers, fibrate, chloramphenicol, phenfluramine, fluoxetine, guanethidine, Mao inhibitors, pentoxifylline, theophylline, caffeine, phenylbutazone, ndi tetracycline gline komanso gati tetracycline;

Ndi munthawi yomweyo kugwiritsa ntchito gliclazide ndi acarbose, zotsatira zowonjezera za hypoglycemic zimawonedwa, zomwe zimafuna kusintha kwa mankhwalawa.

Cimetidine imawonjezera kuchuluka kwa gliclazide mu madzi am'magazi, omwe angayambitse kwambiri hypoglycemia (chapakati mantha dongosolo, kusokonezeka kwa chikumbumtima), motero, kuphatikiza kwa mankhwalawa sikulimbikitsidwa.

Ma Barbiturates, chlorpromazine, glucocorticosteroids, sympathomimetics, glucagon, nicotinic acid, estrogens, progestins, njira zakulera zamkamwa, diuretics, rifampicin, mahomoni a chithokomiro, mchere wa lithiamu umachepetsa mphamvu ya hypoglycemic ya glyclazide.

Kugwiritsa ntchito munthawi yomweyo gliclazide ndi imidazole zotumphukira (kuphatikiza miconazole) ndi zotsutsana.

Kutulutsa mawonekedwe, ma CD ndi mapangidwe a Diabinax

Mapiritsiwo ndi oyera, ozungulira, lathyathyathya, okhala ndi mbali zopindika ndi mzere wolakwika mbali imodzi.

1 tabu
gliclazide	20 mg

Othandizira: cellcrystalline cellulose, wowuma, povidone, sodium methylparaben, colloidal silicon dioxide (aerosil), magnesium stearate, sodium starch glycolate, talc, madzi oyeretsedwa.

20 ma PC. - matuza (2) - mapaketi a makatoni.
20 ma PC. - matuza (3) - mapaketi a makatoni.

Mapiritsiwo ndi oyera, ozungulira, lathyathyathya, okhala ndi mbali zopindika ndi mzere wolakwika mbali imodzi.

1 tabu
gliclazide	40 mg

Othandizira: cellcrystalline cellulose, wowuma, povidone, sodium methylparaben, colloidal silicon dioxide (aerosil), magnesium stearate, sodium starch glycolate, talc, madzi oyeretsedwa.

20 ma PC. - matuza (2) - mapaketi a makatoni.
20 ma PC. - matuza (3) - mapaketi a makatoni.

Mapiritsiwo ndi oyera, ozungulira, lathyathyathya, okhala ndi mbali zopindika ndi mzere wolakwika mbali imodzi.

1 tabu
gliclazide	80 mg

Othandizira: cellcrystalline cellulose, wowuma, povidone, sodium methylparaben, colloidal silicon dioxide (aerosil), magnesium stearate, sodium starch glycolate, talc, madzi oyeretsedwa.

20 ma PC. - matuza (2) - mapaketi a makatoni.
20 ma PC. - matuza (3) - mapaketi a makatoni.

DIABINAX - mavuto

Kuchokera ku endocrine system: hypoglycemia (yokhala ndi mankhwala osokoneza bongo kapena / kapena chakudya chokwanira).

Thupi lawo siligwirizana: zotupa pakhungu, urticaria, pruritus.

Kuchokera pamatumbo am'mimba: kawirikawiri - anorexia, nseru, kusanza, kutsegula m'mimba, kumva kuwawa kapena kupweteka m'dera la epigastric.

Kuchokera ku hemopoietic dongosolo: thrombocytopenia, leukopenia kapena agranulocytosis, kuchepa magazi (nthawi zambiri kusintha).

Malangizo apadera a kutenga DIABINAX

Chithandizo cha Diabinax chikuchitika palimodzi ndi zakudya zama calorie ochepa, zamafuta ochepa.

Pa chithandizo, muyenera kuyang'anira kuchuluka kwa kusala kudya glycemia komanso mukatha kudya.

Mochenjera, mankhwalawa ayenera kugwiritsidwa ntchito kwa odwala omwe ali ndi vuto losakwanira ku adrenal, matenda a chithokomiro (omwe ali ndi vuto la chithokomiro), matenda a pyelonephritis, ndi uchidakwa.

Ngati mukuvulala kwambiri, matenda opatsirana, njira zopangira opaleshoni, mwayi wogwiritsa ntchito insulin uyenera kuganiziridwanso.

Kusintha kwa mlingo ndikofunikira pakulimbitsa thupi ndi malingaliro, kusintha zakudya.

Ngati kusala kapena kumwa mowa, chiopsezo chokhala ndi hypoglycemia chikuchulukirachulukira.

Kukopa pa kuyendetsa magalimoto ndi kayendedwe kazinthu

Pa chithandizo, osavomerezeka kuchita zochitika zomwe zimafuna kuyang'aniridwa mwachangu komanso mwachangu.

Contraindication

Hypersensitivity, mtundu wa 1 matenda a shuga, matenda ashuga a ketoacidosis, diabetesic precoma ndi chikomokere, kwambiri hepatic komanso / kapena aimpso kulephera, kutenga pakati, kuyamwa, osakwana zaka 18. Matenda azachipatala omwe nthawi zambiri amafunikira kukhazikitsa insulini (njira zazikulu zopangira opaleshoni ndi kuvulala, kupsa kwambiri, matenda opatsirana ndi febrile syndrome), uchidakwa, ukalamba.

Momwe mungagwiritsire ntchito: Mlingo ndi njira ya chithandizo

Mkati, pakudya, tsiku loyamba limakhala 80 mg, pafupifupi tsiku lililonse ndi 160-320 mg (kwa 2 Mlingo, m'mawa ndi madzulo). Mlingo umatengera zaka, kuopsa kwa njira ya matenda ashuga, kuchuluka kwa shuga m'magazi ndi maola awiri mutatha kudya.

30 mg mapiritsi otulutsidwa amasulidwe amatengedwa kamodzi tsiku lililonse ndi chakudya cham'mawa. Ngati mankhwalawo adaphonya, ndiye kuti tsiku lotsatira mlingo sayenera kuchuluka. Mlingo woyambitsidwa bwino ndi 30 mg (kuphatikiza kwa anthu opitilira 65). Kusintha kwa mtundu wina uliwonse kumachitika pakatha milungu iwiri. Mlingo wa tsiku ndi tsiku sayenera kupitirira 120 mg. Ngati wodwalayo alandila chithandizo kale ndi sulfonylureas wokhala ndi T1 / 2 mwachitsanzo, chlorpropamide), kuwunikira mosamala (masabata 1-2) ndikofunikira kupewa hypoglycemia chifukwa cha kuperekedwa kwa zotsatira zawo.

Mlingo wa odwala okalamba kapena odwala omwe ali ndi vuto lochepa kwambiri la impso (CC 15-80 ml / min) ndiwofanana ndi pamwambapa.

Kuphatikiza ndi insulin, 60-180 mg ndikulimbikitsidwa tsiku lonse.

Kutulutsa kwa Diabinax, ma CD ndikuphatikizira ndi mankhwala.

Mapiritsiwo ndi oyera, ozungulira, lathyathyathya, okhala ndi mbali zopindika ndi mzere wolakwika mbali imodzi.

1 tabu
gliclazide
20 mg
-«-
40 mg
-«-
80 mg

Omwe amathandizira: cellcrystalline cellulose, wowuma, povidone, sodium methyl paraben, colloidal silicon dioxide (aerosil), magnesium stearate, sodium starch glycolate, talc, madzi oyeretsedwa.

20 ma PC. - matuza (2) - mapaketi a makatoni.
20 ma PC. - matuza (3) - mapaketi a makatoni.

Kufotokozera kwa ZOTHANDIZA ZABWINO.
Zonse zomwe zaperekedwa zimangoperekedwa kuti mudziwe bwino za mankhwalawo, muyenera kufunsa dokotala zokhudzana ndikugwiritsa ntchito.

Zotsatira zoyipa Diabinax:

Kuchokera pamimba yothandizira kugaya chakudya: kawirikawiri - anorexia, nseru, kusanza, kutsegula m'mimba, kupweteka kwa epigastric.

Kuchokera ku hemopoietic system: nthawi zina - thrombocytopenia, agranulocytosis kapena leukopenia, kuchepa magazi (nthawi zambiri kumatha kusintha).

Kuchokera endocrine dongosolo: ndi bongo - hypoglycemia.

Thupi lawo siligwirizana: zotupa pakhungu, kuyabwa.

Malangizo apadera ogwiritsira ntchito Diabinax.

Gliclazide imagwiritsidwa ntchito pochiza matenda osokoneza bongo omwe samatengera insulin kuphatikiza ndi zakudya zama calorie ochepa, zama carb ochepa.

Pa chithandizo, muyenera kuwunika kuchuluka kwa shuga m'magazi pamimba yopanda kanthu ndikatha kudya, kusinthasintha kwa tsiku ndi tsiku m'magazi a shuga.

Pankhani ya chithandizo cha opaleshoni kapena kuwonongeka kwa matenda a shuga, ndikofunikira kulingalira kuti mwina mungagwiritse ntchito insulin pokonzekera.

Ndi chitukuko cha hypoglycemia, ngati wodwalayo akudziwa, shuga (kapena yankho la shuga) amapatsidwa mkati. Pofuna kutaya chikumbumtima, glucose wamitsempha kapena glucagon sc, intramuscularly kapena kudzera m'mitsempha amathandizira. Pambuyo podziwikanso, ndikofunikira kuti wodwalayo adye chakudya chamagulu ambiri kuti mupewe kukonzanso kwa hypoglycemia.

Pogwiritsa ntchito munthawi yomweyo gliclazide yokhala ndi verapamil, kuyang'anira kuchuluka kwa shuga m'magazi kumafunika, ndi acarbose, kuyang'anira mosamala ndi kuwongolera kwa dongosolo lothandizira la hypoglycemic.

Kugwiritsa ntchito pamodzi gliclazide ndi cimetidine osavomerezeka.

Kugwirizana kwa Diabinax ndi mankhwala ena.

Mphamvu ya hypoglycemic ya gliclazide imatha kugwiritsidwa ntchito nthawi imodzi ndi ma pyrazolone ofanana ndi ena, salicylates, phenylbutazone, antibacterial sulfonamide mankhwala, theophylline, caffeine, MAO zoletsa.

Kugwiritsa ntchito munthawi yomweyo kwa osagwiritsa ntchito beta-blockers kumawonjezera mwayi wokhala ndi hypoglycemia, ndipo amathanso kuvala tachycardia ndi kugwedeza kwamanja, chizindikiritso cha hypoglycemia, pomwe thukuta limakulirakulira.

Ndi munthawi yomweyo kugwiritsa ntchito gliclazide ndi acarbose, zotsatira zowonjezera za hypoglycemic zimawonedwa.

Cimetidine imachulukitsa kuchuluka kwa gliclazide mu plasma, komwe kumayambitsa kwambiri hypoglycemia (kupsinjika kwa CNS, kusokonezeka kwa chikumbumtima).

Pogwiritsa ntchito munthawi yomweyo ndi GCS (kuphatikizapo mitundu ya mankhwala ogwiritsira ntchito kunja), okodzetsa, barbiturates, estrogens, progestin, mankhwala osakanikirana a estrogen-progestogen, diphenin, rifampicin, mphamvu ya hypoglycemic ya glyclazide yafupika.

Zotsatira zoyipa

Hypoglycemia (kuphwanya malamulo a dosing komanso kudya mokwanira): kupweteka mutu, kumva kutopa, njala, kutuluka thukuta kwambiri, kufooka, kugona, kugona, kugona, kukwiya, nkhawa, kusakwiya, kuzindikira, kulephera kuganizira komanso kusachedwa kuyankha, kukhumudwa, kusokonezeka m'maso, kuphwanya, kugwedezeka, kusokonezeka kwamalingaliro, chizungulire, kumva zopanda pake, kulephera kudziletsa, kupuma, kukokana, kupsinjika, kuzindikira dicardia.

Kuchokera pakatumbo: dyspepsia (nseru, kutsegula m'mimba, kumva kupsinjika kwa epigastrium), kuchepa kudya - zovuta zimachepa ndi chakudya, kawirikawiri - kusowa kwa chiwindi (cholestatic jaundice, kuchuluka kwa transaminase "chiwindi").

Kuchokera hemopoietic ziwalo: chopinga cha mafupa hematopoiesis (magazi m'thupi, thrombocytopenia, leukopenia).

Thupi lawo siligwirizana: kuyabwa, urticaria, zotupa za maculopapular.

Zina: kuyipa kwa khungu ndi mucous nembanemba Overdose. Zizindikiro: hypoglycemia, kusokonezeka kwa chikumbumtima, hypoglycemic chikomokere.

Chithandizo: ngati wodwala akudziwa, tengani shuga mkatikati, ali ndi vuto losazindikira - mu / poyambira njira yothetsera vuto la hypertonic dextrose (40%), 1-2 mg ya glucagon / m, kuwongolera ndende yamagazi pakatha mphindi 15 zilizonse, komanso kutsimikiza urea, creatinine, ndi ma electrolyte amwazi. Pambuyo podziwikanso, ndikofunikira kuti mupatse wodwalayo chakudya chambiri m'zakudya zamafuta ochepa (kuti mupewe kukonzanso kwa hypoglycemia). Ndi matenda edema, mannitol ndi dexamethasone.

Kutulutsa mawonekedwe, kapangidwe kake ndi ma CD

Mapiritsiwo ndi oyera, ozungulira, lathyathyathya, okhala ndi mbali zopindika ndi mzere wolakwika mbali imodzi.

	1 tabu
gliclazide	20 mg

Omwe amathandizira: cellcrystalline cellulose, wowuma, povidone, sodium methylparaben, colloidal silicon dioxide (aerosil), magnesium stearate, sodium starch glycolate, talc, madzi oyeretsedwa.

20 ma PC. - matuza (2) - mapaketi okhala ndi makatoni 20 ma PC. - matuza (3) - mapaketi a makatoni.

Mapiritsiwo ndi oyera, ozungulira, lathyathyathya, okhala ndi mbali zopindika ndi mzere wolakwika mbali imodzi.

	1 tabu
gliclazide	40 mg

Omwe amathandizira: cellcrystalline cellulose, wowuma, povidone, sodium methylparaben, colloidal silicon dioxide (aerosil), magnesium stearate, sodium starch glycolate, talc, madzi oyeretsedwa.

20 ma PC. - matuza (2) - mapaketi okhala ndi makatoni 20 ma PC. - matuza (3) - mapaketi a makatoni.

Mapiritsiwo ndi oyera, ozungulira, lathyathyathya, okhala ndi mbali zopindika ndi mzere wolakwika mbali imodzi.

	1 tabu
gliclazide	80 mg

Omwe amathandizira: cellcrystalline cellulose, wowuma, povidone, sodium methylparaben, colloidal silicon dioxide (aerosil), magnesium stearate, sodium starch glycolate, talc, madzi oyeretsedwa.

20 ma PC. - matuza (2) - mapaketi okhala ndi makatoni 20 ma PC. - matuza (3) - mapaketi a makatoni.

Kupanga ndi mawonekedwe a kumasulidwa

Piritsi 1 ili ndi 20, 40 kapena 80 mg glycoslide, komanso ochulukitsa (MCC, wowuma, povidone, sodium methyl paraben, colloidal silicon dioxide / aerosil, magnesium stearate, sodium starch glycolate, talc, madzi oyeretsedwa). ., pamakatoni akunyamula matumba 6.

Mlingo ndi makonzedwe

Mkati, mphindi 30-60 musanadye kawiri pa tsiku (m'mawa ndi madzulo).Mlingo umasankhidwa payekha, kutengera zaka za wodwalayo, mawonetseredwe amtundu wa matenda komanso msanga wa kudya glycemia ndi maola awiri mutatha kudya. Nthawi zambiri, muyeso woyamba wa tsiku ndi tsiku ndi 80 mg, pafupifupi ndi 160 mg / tsiku, ndipo kutalika ndi 320 mg / tsiku.

Moyo wa alumali wa Diabinax

Osagwiritsa ntchito tsiku lotha ntchito likusonyezedwa pa phukusi.

Siyani ndemanga yanu

Chidziwitso Chaposachedwa Chosowa Chidziwitso, ‰

Amalembetsa Mankhwala Ovuta Komanso Ofunika

Zikalata zolembetsera Diabinax

P N014190 / 01

Webusayiti yovomerezeka ya kampani RLS ®. Ensaikulopediya yayikulu ya mankhwala osokoneza bongo ndi katundu wa mankhwala omwe amapezeka ku Russia Internet. Ndondomeko yamankhwala Rlsnet.ru imapatsa ogwiritsa ntchito malangizo, mitengo ndi mafotokozedwe a mankhwala, zowonjezera pazakudya, zida zamankhwala, zida zamankhwala ndi zina. Maupangiri a pharmacological akuphatikiza chidziwitso cha kapangidwe ndi mawonekedwe amamasulidwe, zochitika zamankhwala, zisonyezo zogwiritsidwa ntchito, contraindication, zotsatira zoyipa, kuyanjana kwa mankhwala, njira yogwiritsira ntchito mankhwala, makampani opanga mankhwala. Ndondomeko ya mankhwala ili ndi mitengo yamankhwala ndi mankhwala ku Moscow ndi mizinda ina ya Russia.

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Chidziwitsochi cholinga chake ndi akatswiri azachipatala.

DIABINAX: DOSAGE

Bongo

Zizindikiro: kukhuthala kwa khungu, tachycardia, njala, kuchuluka thukuta, kunjenjemera, milandu yayikulu - kuvulala chikumbumtima.

Chithandizo: ngati wodwala akudziwa, shuga kapena njira ya shuga imayikidwa ndi pakamwa. Pangotaya chikumbumtima, 40% glucose solution kapena glucagon s / c, i / m, i / v imayendetsedwa iv. Pambuyo podziwikanso, ndikofunikira kuti wodwalayo adye chakudya chamagulu ambiri kuti mupewe kukonzanso kwa hypoglycemia.