Lisinopril 20mg No. 20

Mavuto a kuthamanga kwa magazi ndi amodzi mwa matenda omwe amapezeka kwambiri mwa anthu amisinkhu yosiyanasiyana. Kusintha kwakanthawi kapena kosafunikira kwa zizindikiro kumafuna kukonza ndi mankhwala oyenera. Chimodzi mwazomwezi mankhwalawa ndi Lisinopril, kuchokera pamalangizo ogwiritsira ntchito omwe timaphunzira pazipsinjo zomwe zimayenera kugwiritsidwa ntchito. Tikuganiziranso zomwe contraindication ikuyenera kuganiziridwa tisanayambe chithandizo.

Malangizo ogwiritsira ntchito

Kodi lisinopril iyenera kukhudzidwa ndi chiyani? Mankhwalawa akuphatikizidwa ndi gulu la ACE zoletsa. Mutatha kumwa mankhwalawa, vasodilation imachitika, motero amasonyezedwa matenda oopsa. Ndi kudya pafupipafupi, ntchito ya minofu ya mtima ndi kayendedwe ka magazi imasintha, mchere wa sodium owonjezera umachotsedwa m'thupi. Mankhwala amachepetsa zizindikiro za diastolic ndi systolic, pomwe samakhudza kugunda kwa mtima.

Mankhwala amamasulidwa mu mawonekedwe a mapiritsi okhala ndi mitundu yosiyanasiyana. Utoto wa mapiritsiwo umatengera kuchuluka kwa zinthu zogwira ntchito. Malalanje - 2,5 mg, lalanje wotumbululuka - 5 mg, pinki - 10 mg, oyera - 20 mg. Mtengo wa Lisinopril ndi ma ruble 70-200. kutengera mlingo komanso kuchuluka kwa mapiritsi omwe ali phukusi.

Zofunika! Lisinopril imawonjezera chiyembekezo cha moyo pamaso pa matenda oopsa a mtima ndi mitsempha yamagazi, imayimitsa kusokonezeka kwamatumbo pambuyo pakuwonekera kwa mtima.

Kuphatikizika kwa mankhwalawa kumaphatikizapo lisinopril dihydrate, kutengera wopanga piritsi atha kuphatikiza zinthu zina zowonjezera zomwe sizikhala ndi vuto lochizira.

Zisonyezero zogwiritsidwa ntchito:

• matenda oopsa komanso matenda ogwirizana osiyanasiyana okondweretsa,
• myocardial infaration mu pachimake siteji,
• kulephera kwa mtima
• kuwonongeka kwa zotumphukira zamanjenje zomwe zimayambitsidwa ndi matenda ashuga.

Mankhwalawa ali ndi ma analogi ambiri omwe ali ndi zofanana zothandizira ndipo samasiyana mtengo - Lysitar, Vitopril, Dapril, Lipril.

Momwe mungamwe mankhwalawa

Musanayambe chithandizo ndi lisinopril, muyenera kuphunzira malangizo kuti mumvetse chifukwa chake mapiritsiwa amathandizira komanso momwe angamwere bwino. Mankhwalawa amathandizidwa kudzera mu impso, chifukwa chake, matenda oopsa a chiwalo ichi ayenera kuuzidwa kwa dokotala asanayambe mankhwala.

Zofunika! Achire zotsatira za mankhwala kumachitika mu ola limodzi, zotsatira zosatha - pambuyo mwezi umodzi. Mankhwalawa amagwira ntchito pang'onopang'ono, choncho sagwiritsidwa ntchito ngati thandizo loyamba pamavuto oopsa.

Lisinopril amakhala ndi mphamvu yayitali, choncho ndikokwanira kuitenga kamodzi patsiku, makamaka m'mawa. Imwani mankhwalawo ndi madzi oyera ambiri. Njira yokwanira yamankhwala imapangidwa ndi dokotala woganiza za zaka za wodwalayo komanso kupezeka kwa matenda osachiritsika.

Mlingo wa mankhwala kutengera matenda:

1. Matenda a shuga - pa nthawi yoyamba ya mankhwala, osaposa 10 mg ya mankhwala patsiku ayenera kumwedwa. Ndikothekanso kukulitsa mlingo mpaka 20 mg, koma izi zitha kuchitika monga zomaliza, popeza pali zovuta zambiri zovuta.
2. Hypertension, matenda oopsa - mankhwala amayamba ndi 10 mg. Kuti muthandizire zowonetsa pazowoneka bwino, muyenera kumwa 20 mg ya mankhwalawa patsiku. Mlingo wotetezeka kwambiri ndi 40 mg.
3. Kulephera kwamtima kosalekeza - chithandizo chimayamba ndi kuchuluka kwa 2,5 mg, pakatha masiku atatu aliwonse. Mlingo wambiri watsiku ndi tsiku ndi 10 mg.

Mankhwalawa ndi Lisinopril, ndikofunikira kuyang'anitsitsa zowunikira, kuyang'ana impso, kubwezeretsa kutayika kwamadzimadzi ndi mchere. Ndikofunikira kuchepetsa kuchuluka kwa zolimbitsa thupi, makamaka nyengo yotentha.

Mankhwala osokoneza bongo osowa - pakadali pano, kuthamanga kwa magazi kumachepa kwambiri, mwina chifukwa chododometsa, kukula kwa aimpso kulephera. Thandizo loyamba ndi kupweteka kwam'mimba, kukhazikitsidwa kwa mchere.

Zofunika! Mankhwalawa amalepheretsa chidwi ndi chidwi, motero, ndikofunikira kupewa kuyendetsa galimoto, malo okwera ndi ntchito yapansi panthaka.

Contraindication ndi zoyipa

Lisinopril amathandiza kwambiri kuthamanga kwa magazi, koma mankhwalawa ali ndi zovuta zambiri. Ngati mutsatira mankhwalawo ndikutsatira njira yolondola yolandirira, ndiye kuti zotsatirapo zoyipa mukamamwa mankhwalawo sizikuwoneka kapena kutha mkati mwa masiku ochepa.

• kupweteka pachifuwa, kuchepa kwambiri kwa kuthamanga kwa magazi,
• kuwonongeka mu potency,
• zovuta m'mimba zomwe zimayambitsa mawonekedwe a mseru komanso kusanza,
• kuchuluka kwa ESR, kuchepa kwa hemoglobin,
• kuchuluka kwa nayitrogeni wa urea ndi keratin,
• kupweteka kwa molumikizana
• kufooka kwa minyewa, migraine, chizungulire.

Pa gawo loyambirira la mankhwalawa, kusintha kwa thupi lanu mu mawonekedwe a zotupa pakhungu kumatha kuchitika, nthawi zina edema ya Quincke imatha kuchitika. Nthawi zambiri, kumwa mankhwala kumayendera limodzi ndi chifuwa chosabereka.

The contraindication chachikulu ndi kusalolerana payekha kwa magawo a mankhwala ndi lactose, hypersensitivity kwa mankhwala ochokera ku gulu la ACE zoletsa, angioedema, idiopathic edema. Lisinopril amatsutsana panthawi yoyembekezera nthawi iliyonse, ndipo kugwiritsa ntchito mkaka wa m`mawere kumatheka pokhapokha kuyamwitsa kuyimitsidwa. Palibe deta yodalirika yokhudza kugwiritsa ntchito mankhwalawa mu ana, chifukwa chake sichiyikidwa kwa anthu ochepera zaka 18.

Kusamala ndikuyang'aniridwa ndi dokotala pafupipafupi kuyenera kutenga lisinopril kwa anthu okalamba, odwala matenda ashuga, ngati pali mbiri yamatenda a impso, kapena mavuto ndi kufalikira kwa ziwalo.

Titha kunena zenizeni zakuchepa kwa Lisinopril ndi mowa. Pa chithandizo, zakumwa ndi zokonzekera zomwe zimakhala ndi ethanol ziyenera kuthetsedwa. Mankhwalawa amalimbikitsa zovuta zomwe zimabweretsa mowa mthupi, zomwe zimatha kuyambitsa zovuta zazikulu za chiwindi.

Zofunika! Asanatenge Lisinopril kuti akakamizike, ndikofunikira kuti adziwe zoyeserera kuti asachotse kupezeka kwa matenda a impso ndikuchotsa madzi amthupi.

Lisinopril kapena enalapril - ndibwino?

Lisinopril amachepetsa kuthamanga kwa magazi, ndipo njira yothandizira odwala imakhala yotalikirapo kuposa ya enalapril, yomwe imayenera kumwa kawiri patsiku. Mankhwalawa amagwiritsidwa ntchito chimodzimodzi, koma enalapril samakhudza potency ndipo amachotsedwa ndi chiwindi ndi impso.

Diroton kapena Lisinopril - ndibwino?

Mankhwalawa amafanana kwambiri - amamasulidwa mu mapiritsi okhala ndi mlingo wa 5-20 mg, ndikokwanira kumwa iwo kamodzi patsiku, zotsatira zosatha zimatha pambuyo pa masabata 2-4. Koma kuti mukhalebe olondola, mlingo wa Diroton uyenera kukhala wowirikiza kawiri kuposa Lisinopril.

Pali zosiyana pakati pa zosokoneza. Diroton sayenera kutengedwa ndi anthu omwe ali ndi chibadwa chokhala ndi edema ya Quincke. Lisinopril saloledwa kutenga ndi lactose tsankho. Kupanda kutero, mphamvu ya mankhwalawo ndi yofanana.

Lisinopril kapena Lozap - ndibwino?

Mankhwalawa onse ali m'gulu la ACE inhibitor, koma Lozap ndi mankhwala odula. Amangopatsidwa pokhapokha ngati wodwalayo akupitilizabe kuloza mankhwala ena onse m'gululi.

Mankhwala aliwonse omwe ali ndi kuthamanga kwa magazi amatha kumwa pokhapokha mukaonana ndi mtima - mankhwala onse omwe ali ndi mphamvu zambiri ali ndi zotsutsana zambiri. Kudzichitira wekha matenda oopsa kungapangitse kuchepa kwa zizindikirozo pochepera zovomerezeka, chikomokere ndi zotsatirapo zina zovuta.

Makhalidwe wamba. Zopangidwa:

Lisinopril 5 mg Wothandizika: lisinopril dihydrate lolingana 5 mg wa lisinopril,
Lisinopril 10 mg Wothandizika: lisinopril dihydrate lolingana 10 mg wa lisinopril,
Lisinopril 20 mg Wogwira pophika: lisinopril dihydrate lolingana 20 mg wa lisinopril,
Omwe amathandizira: shuga ya mkaka (lactose), calcium yochepa.

Kufotokozera: Mapiritsi 5 mg ndi 10 mg - yoyera kapena pafupifupi yoyera, yosalala, yokhala ndi bevel. Mapiritsi 20 mg - oyera kapena pafupifupi oyera, osalala-mawonekedwe a cylindrical, okhala ndi chamfer ndi chiwopsezo.

Katundu

Mankhwala ACE inhibitor, amachepetsa kupangika kwa angiotensin II kuchokera ku angiotensin I. Kuchepa kwa zomwe angiotensin II kumabweretsa kutsika kwachindunji kutulutsidwa kwa aldosterone. Amachepetsa kuchepa kwa bradykinin ndikuwonjezera kaphatikizidwe ka prostaglandins. Kuchepetsa kwathunthu zotumphukira mtima kukana, kuthamanga kwa magazi (BP), preload, kukakamira m'mapapo m'mimba, kumapangitsa kuchuluka kwa magazi kwa miniti ndikuchulukitsa kulolerana kwa mtima ndi nkhawa kwa odwala omwe ali ndi vuto la mtima. Imakulitsa mitsempha pamlingo wokulirapo kuposa mitsempha. Zotsatira zina zimafotokozedwa ndi kuthana ndi machitidwe a minye renin-angiotensin. Pogwiritsa ntchito nthawi yayitali, hypertrophy ya myocardium ndi makhoma amitsempha ya mtundu wotsalira amachepa. Amasintha magazi kupita ku ischemic myocardium.
ACE inhibitors imakulitsa chiyembekezo cha moyo kwa odwala omwe ali ndi vuto losatha la mtima, achepetsa kudutsa kwamanzere kwamitsempha yamagazi kwa odwala pambuyo poyambitsa myocardial infarction popanda mawonekedwe a mtima olephera. Mphamvu ya antihypertensive imayamba pakatha pafupifupi maola 6 ndipo imatha kwa maola 24. Kutalika kwa zotsatira zimatengera mlingo. Kukhazikika kwa zochita kumachitika pambuyo pa ola limodzi. Kuchuluka kwake kumatsimikiziridwa pambuyo pa maola 6-7. Ndi ochepa matenda oopsa, zotsatira zake zimadziwika m'masiku oyamba pambuyo pa kuyamba kwa mankhwalawa, mokhazikika umayamba pambuyo pa miyezi 1-2. Ndi kusiyiratu kwakumwa kwa mankhwalawo, kuchuluka kwakukulu kwa magazi sikunawonedwe.
Kuphatikiza pakuchepetsa kuthamanga kwa magazi, lisinopril imachepetsa albuminuria. Odwala omwe ali ndi hyperglycemia, zimathandizanso kuti mawonekedwe a glomerular endothelium awonongeke.
Lisinopril sichikhudzanso kuchuluka kwa shuga wamagazi mwa odwala matenda a shuga ndipo sikuti kumawonjezera kuchuluka kwa hypoglycemia.

Pharmacokinetics Mafuta: Pambuyo pakukonzekera pakamwa, pafupifupi 25% ya Lisinopril amachotsedwa m'mimba. Kudya sizikhudzana ndi mayamwa. Bioavailability ndi 29%.
Kugawa. Pafupifupi sizigwirizana ndi mapuloteni a plasma. Pulogalamu yayikulu kwambiri ya plasma (90 ng / ml) imafikiridwa patatha maola 7. Chilolezo kudzera mu magazi-ubongo ndi chotchinga chachikulu.
Kupenda. Lisinopril samapangidwa mwachilengedwe m'thupi.
Kuswana. Imafufutidwa ndi impso zosasinthika. Hafu ya moyo ndi maola 12.
Pharmacokinetics m'magulu ena a odwala: Odwala omwe ali ndi vuto lalikulu la mtima, mayamwidwe ndi chiphaso cha Lisinopril amachepetsa.
Odwala omwe amalephera kupweteka kwa impso, kuchuluka kwa lisinopril kumakhala kangapo kuposa kuchuluka kwa plasma yamagazi odzipereka, ndipo pakuwonjezereka nthawi yakufika pazovuta zambiri mu plasma yamagazi ndi kuwonjezeka kwa theka la moyo.
Odwala okalamba, kuchuluka kwa mankhwalawa m'madzi am'magazi komanso malo omwe amaponderezedwa ndizochulukirapo kawiri kuposa kwa achinyamata.

Zisonyezero zogwiritsidwa ntchito:

- Matenda oopsa a arterial (mu monotherapy kapena kuphatikiza mankhwala ena a antihypertensive),
- Kulephera kwamtima kosalekeza (monga gawo limodzi la mankhwala ochiritsira odwala omwe amatenga digito ndi / kapena okodzetsa),
- Chithandizo choyambirira cha infarction yanyengo yam'mimba (mu maola 24 oyamba ndi hemodynamics yokhazikika kuti muzitha kuzitsatira ndikuletsa kukomoka kwamitsempha yamanja ndi mtima kulephera),
- Diabetesic nephropathy (kuchepa kwa albuminuria m'magazi omwe amadalira insulin omwe amakhala ndi magazi abwinobwino komanso odwala osagwirizana ndi insulin omwe amadalira matenda oopsa).

Mlingo ndi makonzedwe:

Mkati, ngakhale zakudya. Ndi ochepa matenda oopsa, odwala osalandira mankhwala ena a antihypertensive amapatsidwa 5 mg kamodzi patsiku. Ngati palibe zotheka, mankhwalawa amawonjezeka masiku onse awiri ndi 5 mg mpaka pakati pa 20 mg mg / tsiku (kuwonjezera kuchuluka kwa 40 mg / tsiku nthawi zambiri sikuti kumabweretsa kuchepa kwa kuthamanga kwa magazi).
Mulingo wamba wokonzanso tsiku lililonse ndi 20 mg. Mlingo wambiri watsiku ndi tsiku ndi 40 mg. Zotsatira zonse zimayamba pambuyo pa masabata 2-4 kuyambira pa chiyambi cha mankhwala, zomwe zimayenera kukumbukiridwa pakukweza mlingo. Ndi matenda osakwanira azaumoyo, ndizotheka kuphatikiza mankhwalawa ndi mankhwala ena a antihypertensive.
Ngati wodwalayo alandila chithandizo choyambirira ndi okodzetsa, ndiye kuti kumwa mankhwalawa kuyenera kuyimitsidwa masiku 2-3 Lisinopril isanayambike. Ngati izi sizingatheke, ndiye kuti mankhwalawa a Lisinopril sayenera kupitirira 5 mg patsiku. Pankhaniyi, mutatenga mlingo woyamba, kuyang'aniridwa kwa achipatala kumalimbikitsidwa kwa maola angapo (mphamvu yayitali imatheka pambuyo pafupifupi maola 6), chifukwa kuchepa kwakukulu kwa magazi kumatha kuchitika.
Pankhani ya kukonzanso kwamitsempha yamagazi kapena zochitika zina ndi kuchuluka kwa dongosolo la renin-angiotensin-aldosterone, timafunikanso kupereka mankhwala ochepa a 2.5-5 mg patsiku, motsogozedwa ndi achipatala (kuwongolera kuthamanga kwa magazi, ntchito yaimpso, potaziyamu yambiri mu seramu yamagazi). Mlingo wokonza, popitiliza kuthandizira, uyenera kutsimikiziridwa kutengera mphamvu ya magazi.
Pankhani ya kulephera kwa impso, chifukwa chakuti lisinopril imachotsedwa kudzera mu impso, mlingo woyambirira uyenera kutsimikiziridwa malinga ndi chilolezo cha creatinine, ndiye, molingana ndi zomwe zimachitika, mlingo wokonzanso uyenera kukhazikitsidwa pansi pazoyang'anira kawirikawiri aimpso, potaziyamu, masodium seramu.

Kulengedwa kwa creatinine ml / mphindi koyamba mg / tsiku
30-70 5-10
10-30 2,5-5
zosakwana 10,5
(kuphatikizapo odwala omwe amathandizidwa ndi hemodialysis)

Ndi kulimbitsa kwamankhwala oopsa, chithandizo chokhalitsa kwa nthawi yayitali cha 10-15 mg / tsiku chimasonyezedwa.
Kulephera kwamtima kosalekeza - kuyamba ndi 2,5 mg kamodzi patsiku, ndikutsatira kuwonjezereka kwa 2,5 mg mu masiku 3-5 pamasiku onse, kumathandizira tsiku lililonse la 5-20 mg. Mlingo sayenera kupitirira 20 mg patsiku.
Mwa okalamba, kutchulidwa kwa nthawi yayitali kwambiri kumawonedwa, komwe kumalumikizidwa ndi kuchepa kwa kuchuluka kwa Lisinopril (tikulimbikitsidwa kuti muyambe kulandira mankhwala ndi 2.5 mg / tsiku).
Pachimake myocardial infarction (monga gawo la mankhwala osakanikirana)
Patsiku loyamba - 5 mg pakamwa, ndiye 5 mg tsiku lililonse, 10 mg masiku awiri aliwonse komanso 10 mg kamodzi patsiku. Odwala omwe ali ndi kuphwanya kwakumwa kwa myocardial, mankhwala ayenera kugwiritsidwa ntchito kwa milungu 6.
Kumayambiriro kwa mankhwalawa kapena masiku oyamba atatu pambuyo panjira yodwala kwambiri odwala omwe ali ndi magazi ochepa (120 mm Hg kapena m'munsi), mlingo wochepetsetsa uyenera kutumikiridwa - 2.5 mg. Pakakhala kuchepa kwa kuthamanga kwa magazi (magazi a systolic m'munsi kapena ofanana ndi 100 mm Hg), tsiku lililonse mlingo wa 5 mg ukhoza, ngati pakufunika, uchepetse kwakanthawi mpaka 2,5 mg. Pankhani ya kuchepa kwa magazi kwakanthawi (kuthamanga kwa magazi m'munsi mwa 90 mm Hg kwa ola limodzi), chithandizo ndi Lisinopril ziyenera kusiyidwa.
Matenda a shuga.
Odwala omwe ali ndi matenda osokoneza bongo omwe amadalira shuga, 10 mg ya Lisinopril amagwiritsidwa ntchito kamodzi patsiku.Mlingo umatha, ngati pakufunika, uwonjezeke mpaka 20 mg kamodzi patsiku kuti akwaniritse kuthamanga kwa magazi m'munsi mwa 75 mm Hg. m'malo okhala. Odwala omwe ali ndi matenda a shuga omwe amadalira insulin, mlingo ndi womwewo, kuti akwaniritse kuthamanga kwa magazi m'munsi mwa 90 mm Hg. m'malo okhala.

Zomwe Mungagwiritse Ntchito:

Zizindikiro zapadera.
Nthawi zambiri, kutsika kwamphamvu kwa kuthamanga kwa magazi kumachitika ndi kuchepa kwamphamvu kwamadzimadzi chifukwa cha kukodzetsa, kuchepa kwa mchere mu chakudya, kudzimbidwa, kutsegula m'mimba, kapena kusanza. Odwala omwe ali ndi vuto la mtima losalephera limodzi ndi kulephera kwaimpso kapena popanda iwo, kuchepa kwamphamvu kwa magazi kumatheka. Nthawi zambiri zimapezeka kwa odwala omwe ali ndi vuto lalikulu la mtima, chifukwa chogwiritsa ntchito kuchuluka kwa kukodzetsa, hyponatremia, kapena vuto laimpso. Odwala otere, chithandizo ndi Lisinopril ziyenera kuyamba kuyang'aniridwa ndi dokotala (mosamala, kusankha kwa mankhwala ndi okodzetsa).
Malamulo omwewo ayenera kutsatiridwa popereka odwala omwe ali ndi matenda a mtima, kuchepa kwa magazi m'thupi, komwe kuchepa kwambiri kwa magazi kumatha kubweretsa kuphwanya pansi kwa myocardial kapena stroke.
Kuchepa kwakanthawi kwa hypotensive si kuphwanya kumwa potsatira mlingo wotsatira wa mankhwalawa.
Mukamagwiritsa ntchito Lisinopril mwa odwala ena omwe ali ndi vuto la mtima losalephera, koma ndi vuto labwinobwino kapena lotsika magazi, kuchepa kwa kuthamanga kwa magazi kumatha kuchitika, zomwe nthawi zambiri sizikhala chifukwa chosiya kulandira chithandizo.
Musanayambe chithandizo ndi Lisinopril, ngati kuli kotheka, sinthani kuchuluka kwa sodium ndi / kapena kupanga kuchuluka kwa madzi otayika, yang'anirani mosamala momwe mankhwalawo akumayambiriro a Lisinopril. Ngati aimpso mtsempha wamagazi (makamaka ndi stenosis, kapena pamaso pa stenosis ya mtsempha wama impso), komanso kulephera kwa magazi chifukwa chosowa sodium ndi / kapena madzimadzi, kugwiritsidwa ntchito kwa Lisinopril kumatha kubweretsanso vuto laimpso, kulephera kwaimpso. Sizingasinthe pambuyo popewa mankhwala.
Mu pachimake myocardial infarction:
Kugwiritsidwa ntchito kwa mankhwala othandizira (thrombolytics, acetylsalicylic acid, beta-blockers) akuwonetsedwa. Lisinopril angagwiritsidwe ntchito molumikizana ndi mtsempha wamagetsi kapena kugwiritsa ntchito njira zina za nitroglycerin.
Opaleshoni yopangira opaleshoni / opaleshoni wamba.
Ndi njira zambiri zopangira opaleshoni, komanso kugwiritsa ntchito mankhwala ena omwe amachepetsa kuthamanga kwa magazi, Lisinopril, kutsekereza mapangidwe a angiotensin II, angayambitse kuchepa kosadziwika kwa kuthamanga kwa magazi.
Odwala okalamba, kumwa womwewo kumawonjezera kuchuluka kwa mankhwalawa m'magazi, chifukwa chake, chisamaliro chapadera chimafunikira pakudziwa mlingo.
Popeza chiopsezo cha agranulocytosis sichingathetsedwe, kuwunika kwa chithunzi cha magazi kumafunika. Mukamagwiritsa ntchito mankhwalawa pansi pa dialysis ndi polyacryl-nitrile membrane, mantha a anaphylactic angachitike, motero, tikulimbikitsidwa kuti mitundu ina ya membrane wa dialysis, kapena poika ma antihypertgency agents ena.
Kukopa pa luso loyendetsa magalimoto ndi zida.
Palibe chidziwitso chokhudzana ndi Lisinopril pakutha kuyendetsa magalimoto ndi njira zomwe zimagwiritsidwa ntchito pochizira Mlingo, koma muyenera kukumbukira kuti chizungulire nchotheka, motero muyenera kusamala.

Zotsatira zoyipa:

Zotsatira zoyipa kwambiri: chizungulire, kupweteka mutu, kutopa, kutsegula m'mimba, kutsokomola, nseru.
- Kuchokera pamtima dongosolo: kuchepa kwa kuthamanga kwa magazi, kupweteka pachifuwa, osawerengeka - orthostatic hypotension, tachycardia, bradycardia, Zizindikiro zoyipa za kulephera kwa mtima, kusokonekera kwa atrioventricular conduction, kulowetsedwa kwa mtima, kuvulala kwamtima.
- Kuchokera pakati mantha dongosolo: kusinthasintha kwa mphamvu, chisokonezo, paresthesia, kugona, kugwedeza mwamphamvu minofu ya miyendo ndi milomo, kawirikawiri - asthenic syndrome.
- Kuchokera ku hemopoietic dongosolo: leukopenia, neutropenia, agranulocytosis, thrombocytopenia, kuchepa magazi (kuchepa kwa hemoglobin, hematocrit, erythrocytopenia).
- Zizindikiro zasayansi: hyperkalemia, hyponatremia, kawirikawiri - ntchito yayikulu ya "chiwindi" michere, hyperbilirubinemia, kuchuluka kwa urea ndi creatinine.
- Kuchokera pakapumidwe: dyspnea, bronchospasm.
- Kuchokera pamimba yodyetsera: pakamwa pouma, kukomoka, kusanza, kusintha kwa ululu, kupweteka kwam'mimba, kapamba, hepatocellular kapena cholestatic jaundice, hepatitis.
- Kuchokera pakhungu: urticaria, kutuluka thukuta, kuyabwa, alopecia, photosensitivity.
- Kuchokera kwa genitourinary dongosolo: kuphwanya kwaimpso ntchito, oliguria, anuria, pachimake impso kulephera, uremia, proteinuria, kuchepa potency. Thupi lawo siligwirizana: angioedema a nkhope, miyendo, milomo, lilime, epiglottis ndi / kapena larynx, zotupa pakhungu, kuyabwa, kutentha thupi, zotsatira zoyeserera za antinuclear, kuchuluka kwa erythrocyte sedimentation rate (ESR), eosinophilia, leukocytosis. Nthawi zosowa kwambiri, interstitial angioedema.
- Zina: myalgia, arthralgia / nyamakazi, vasculitis.

Mogwirizana ndi mankhwala ena:

Lisinopril amachepetsa mayendedwe a potaziyamu m'thupi panthawi ya mankhwala okodzetsa. Chisamaliro chofunikira chimafunikira mukamagwiritsa ntchito mankhwalawa ndi: potaziyamu-yosaleketsa okodzetsa (spironolactone, triamteren, amiloride), potaziyamu, malo ena a sodium chloride omwe ali ndi vuto la potusitomiki (chiwopsezo cha kukhala ndi hyperkalemia imawonjezeka, makamaka ndi vuto la aimpso) kwa dokotala wokhazikika wowunika seramu potaziyamu wambiri ndi aimpso.
Chenjezo atha kugwiritsidwa ntchito limodzi:
- ndi okodzetsa: Ndi makonzedwe owonjezera a okodzetsa kwa wodwala omwe akutenga Lisinopril, monga lamulo, antihypertensive yowonjezera imachitika - chiwopsezo cha kuchepa kwa magazi,
- ndi othandizira ena a antihypertensive (zowonjezera),
- ndi mankhwala omwe si a steroidal anti-yotupa (indomethacin, etc.), estrogens, komanso adrenostimulants - kuchepa kwa mphamvu ya antihypertensive ya Lisinopril,
- ndi lifiyamu (lithiamu excretion imatha kuchepa, motero, seramu lifiyamu iyenera kuyang'aniridwa pafupipafupi),
- ndi ma antacid ndi colestyramine - amachepetsa mayamwidwe m'mimba. Mowa umawonjezera mphamvu ya mankhwalawo.

Zoyipa:

Hypersensitivity ku Lisinopril kapena zoletsa zina za ACE, mbiri ya angioedema, kuphatikiza kugwiritsa ntchito zoletsa za ACE, cholowa cha cholowa cha Quincke, pansi pa zaka 18 (mphamvu ndi chitetezo sizinakhazikitsidwe).

Ndi chenjezo: kukanika kwa aimpso, kupindika minyewa ya m'mitsempha. kuphatikizapo cerebrovascular insufficiency), matenda a mtima, kuchepa kwa mtima, matenda a autoimmune matenda okhudzana ndi minofu (kuphatikizapo scleroderma, systemic lupus erythematosus), chopinga cha marow hematopoiesis, zakudya ndi kuletsa kwa sodium: machitidwe a hypovolemic (kuphatikizapo chifukwa cha matenda am'mimba, kusanza), ukalamba.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere. Kugwiritsa: Lisinopril pa mimba ndi contraindication. Mimba ikakhazikitsidwa, mankhwalawo amayenera kusiyidwa posachedwa. Kulandila kwa zoletsa za ACE mu II ndi III trimester ya mimba kumakhala ndi zovuta pa mwana wosabadwayo (kutchulidwa kwa kuchepa kwa kuthamanga kwa magazi, kulephera kwa impso, hyperkalemia, cranial hypoplasia, kufa kwa intrauterine). Palibe zambiri pazotsatira zoyipa za mankhwalawa mwana wosabadwa ngati agwiritsidwa ntchito nthawi yoyamba. Kwa makanda ndi makanda omwe amakhala ndi intrauterine kukhudzana ndi ma inhibitors a ACE, tikulimbikitsidwa kuyang'anira mosamala kuti mupeze nthawi yake yomwe kuchepa kwa magazi, oliguria, hyperkalemia
Lisinopril amawoloka placenta. Palibe chidziwitso pakulowerera kwa lisinopril mkaka wa m'mawere. Kwa nthawi ya mankhwala ndi mankhwalawa, ndikofunikira kusiya kuyamwitsa.

Bongo

Zizindikiro (zimachitika pakumwa mlingo umodzi wa 50 mg kapena kupitilira): kuchepa kwamphamvu kwa magazi, kukamwa kowuma, kugona, kukodyeka kwamkodzo, kudzimbidwa, kuda nkhawa, kuchuluka kwa kusokonekera. Chithandizo: monga mankhwala othandizira, kutsitsa kwamadzimadzi, kuwongolera kuthamanga kwa magazi, kusamala kwa madzi ndi kusintha kwa matendawa.
Lisinopril amachotsedwa m'thupi kudzera pa hemodialysis.

Malo opumulira:

5, 10 kapena 20 mg mapiritsi. 10 mapiritsi pachimake pa polyvinyl chloride film ndi aluminium zojambulazo, mapiritsi 20 kapena 30 mu akhoza kugwiritsa galasi lopepuka kapena polima kapena kapena botolo la polymer, Aliyense angathe kapena botolo, kapena 1, 2 kapena 3 chithuza chamadzimadzi palimodzi ndi malangizo ogwiritsira ntchito kuyikidwa mu paketi ya kadikhadi.