Momwe mungagwiritsire ntchito mankhwala Glyclazide?

Fomu ya Mlingo - mapiritsi: flat-cylindrical, pafupifupi oyera kapena oyera, ali pachiwopsezo ndi chinsalu (10 chilichonse chimatulutsidwa, mu paketi ya makatoni 3 kapena 6 ndi malangizo ogwiritsira ntchito Gliclazide).

Piritsi 1:

yogwira mankhwala: gliclazide - 80 mg,
othandizira zigawo zikuluzikulu: wowuma 1500 (wowerengeka pregelatinized wowuma), sodium lauryl sulfate, lactose monohydrate, magnesium stearate, croscarmellose sodium.

Mankhwala

Glyclazide - sulfonylurea yochokera m'badwo wachiwiri, wothandizira wa hypoglycemic.

Limagwirira a ntchito ya mankhwala chifukwa amatha kulimbikitsa chinsinsi cha pancreatic insulin, kuwonjezera insulin-chinsinsi mphamvu ya glucose, ndikuwonjezera chidwi cha minofu kuti insulin. Gliclazide imapangitsa ntchito ya michere yama intracellular monga minofu ya glycogen synthetase. Amachepetsa nthawi kuchokera pakudya mpaka kuyamba kwa insulin. Mosiyana ndi zotumphukira zina za sulfonylurea, zimabwezeranso pachimake pachiwopsezo cha insulin. Amachepetsa postprandial hyperglycemia.

Gliclazide imathandiza mu kagayidwe kazakudya kagayidwe kachakudya komanso matenda osokoneza bongo, kuphatikizapo odwala omwe ali ndi kunenepa kwambiri kwa malamulo. Matenda a mtundu wa glycemic amadziwika masiku angapo atangoyamba kumene chithandizo. Mankhwala amalepheretsa kukula kwa microvasculitis, kuphatikizapo kuwonongeka kwa diso. Imaphatikizira kuphatikizika kwa maselo. Kuchulukitsa kwa fibrinolytic ndi heparin, komanso kulolerana kwa heparin. Kuchulukitsa kwakukulu kumakhala ndi chizindikiritso chachibale. Imawonetsa ntchito ya antioxidant, imasintha vascularization.

Ndi diabetesic nephropathy, proteinuria imachepetsedwa. Kugwiritsa ntchito nthawi yayitali, zimathandizira kuchepetsa proteinuria odwala matenda ashuga nephropathy.

Popeza mankhwalawa ali ndi zotsatira zoyambira pachimake cha insulin komanso sichimayambitsa hyperinsulinemia, sizikuwonjezera kuchuluka kwa thupi. Komanso, odwala onenepa kwambiri, gliclazide imapangitsa kuti achepetse thupi, malinga ndi zakudya zochepa zopatsa mphamvu.

Imakhala ndi antiatherogenic ntchito, imachepetsa kuchuluka kwa mafuta m'thupi m'magazi.

Mphamvu ya antioxidant ndi hemovascular ya gliclazide amathandiza kuchepetsa chiopsezo chokhala ndi zotumphukira za mtima mwa odwala omwe ali ndi matenda a shuga.

Pharmacokinetics

Gliclazide imadziwika ndi mayamwidwe ambiri. Pambuyo pakamwa 40 mg, pazipita ndende (C_max) imadziwika pambuyo pa maola awiri ndi atatu ndipo imakhala 2-3 μg / ml, mutatha kumwa 80 mg, Zizindikiro ndi maola 4 ndi 2.2-8 μg / ml, motsatana.

Kulumikizana ndi mapuloteni a plasma ndi 85-97%, voliyumu yogawa ndi 0,35 l / kg. Kuzunzika koyenera kumafika patadutsa masiku awiri.

Gliclazide imapangidwa mu chiwindi ndikupanga 8 metabolites. Kuchuluka kwa metabolite yayikulu ndi 2-3% ya kuchuluka kwa zonse zomwe zimatengedwa, zilibe katundu wa hypoglycemic, koma zimakhudza ma microcirculation.

Hafu ya moyo (T_½) - maola 8-12. Mankhwalawa amachotsedwa makamaka ndi impso: 70% - mu mawonekedwe a metabolites, osapitirira 1% - osasinthika. Pafupifupi 12% ya gliclazide imatulutsidwa ndi matumbo ngati metabolites.

Magawo a Pharmacokinetic nthawi zina:

ntchito yaimpso ndi chiwindi: vuto la hepatic komanso kufinya kwambiri kwa impso, kusintha kwa pharmacokinetics ya gliclazide ndikotheka, zochitika za hypoglycemia mwa odwala zotere zimatha kukhala zazitali, zomwe zimafuna njira zokwanira,
ukalamba: palibe mankhwala a pharmacokinetic omwe adawonedwa.

Contraindication

lembani 1 matenda a shuga (kuphatikiza mtundu wa achinyamata MYONI),
diabetesic hyperosmolar precoma ndi chikomokere,
matenda ashuga ketoacidosis,
hypo- ndi hyperthyroidism,
aimpso kwambiri ndi / kapena kulephera kwa chiwindi,
kuvulala kwambiri ndi kuwotchedwa,
galactose tsankho, kufupika kwa lactase, shuga-galactose malabsorption,
wazaka 18
mimba ndi mkaka wa m`mawere
kugwiritsa ntchito miconazole,
Hypersensitivity chilichonse chigawo chimodzi cha mankhwala, sulfonamides kapena mankhwala ena a gulu la sulfonylurea.

Sitikulimbikitsidwa kugwiritsa ntchito Gliclazide kuphatikiza ndi danazol, phenylbutazone, ethanol.

Gliclazide, malangizo ntchito: njira ndi mlingo

Mapiritsi a Glyclazide ayenera kumwedwa ndi chakudya.

Kumayambiriro kwa mankhwalawa, 80 mg (piritsi 1) nthawi zambiri amapatsidwa nthawi 1 patsiku. M'tsogolomu, dokotala amasankha mlingo wokonzera payekha, umatha kukhala 80-320 mg patsiku. Mlingo umodzi sayenera kupitirira 160 mg. Mukamapereka mankhwala okwanira, muyenera kumwa mankhwalawa 2 pa tsiku nthawi ya chakudya chachikulu.

Mlingo woyambitsidwa wa odwala okalamba (wopitilira zaka 65) ndi mapiritsi a 40 mg kamodzi patsiku. Ngati ndi kotheka, kupitilizanso kuchuluka kwa mankhwalawa. Mlingo wowonjezera uyenera kuchitidwa pakadutsa masiku osachepera 14 motsogozedwa ndi shuga m'magazi.

Mlingo wochepetsetsa wa tsiku ndi tsiku (40-80 mg), Gliclazide amalimbikitsidwa kwa odwala omwe ali ndi impso / hepatic insufficiency, odwala ofooka, komanso odwala omwe ali pachiwopsezo chotenga matenda a hypoglycemia: zovuta kapena kuperewera bwino kwa endocrine (kuphatikiza hypothyroidism, adrenal ndi pituitary insufficiency), zilonda zam'mimba kwambiri (kuphatikizapo matenda a mtima oopsa, atherosulinosis, matenda oopsa a mitsempha ya carotid), kusachita bwino kapena kuperewera kwa vuto la kuperewera kwa thupi, peri Kutha kwa glucocorticosteroids atatha nthawi yayitali makonzedwe ndi / kapena makonzedwe apamwamba.

Posamutsa wodwala ku Glyclazide kuchokera kwa wothandizira wina wamlomo wamkamwa, nthawi yofunikira siyofunika. Pankhani ya kukonzanso kwina kwa sulfonylurea ndi theka lalitali (mwachitsanzo, chlorpropamide) ndi gliclazide, kuyang'anira mosamala mkhalidwe wa wodwalayo kuyenera kuthandizidwa kuti mupewe kukula kwa zotsatira zowonjezera komanso hypoglycemia.

Ngati ndi kotheka, Gliclazide ikhoza kutumikiridwa limodzi ndi insulin, alpha-glucosidase inhibitors ndi biguanides.

Odwala omwe amamwa Glyclazide osawongolera mokwanira kuchuluka kwa shuga m'magazi amatha kupatsidwa insulin. Chithandizo chikuyenera kuchitika moyang'aniridwa ndi dokotala.

Mukaphonya mlingo wotsatira, ndizoletsedwa kumwa kawiri tsiku lotsatira.

Kutengera kagayidwe kazomwe kagayidwe ka magazi (glucose, glycated hemoglobin) wodwala kameneka, muyezo wa mankhwala munthawi ya mankhwalawa amatha kusintha.

Zotsatira zoyipa

Kuchokera kumimba: kupweteka kwam'mimba, kutsekula m'mimba, kudzimbidwa, kusanza (zovuta za izi zimachepa ngati mumwa mankhwala ndi chakudya),
mbali ya chiwindi ndi biliary thirakiti: kuchuluka kwa chiwindi michere, cholestatic jaundice, chiwindi,
Kuchokera ku ziwalo za hemopoietic: leukopenia, thrombocytopenia, kuchepa magazi, granulocytopenia,
Kuchokera pamtima dongosolo: epistaxis, ochepa hypotension, cerebrovascular insufficiency, arteritis, palpitations, mtima kulephera, tachycardia, myocardial infarction, kutupa kwa miyendo, thrombophlebitis,
mbali ya gawo la masomphenyawo: kuwonongeka kwakanthawi kochepa (nthawi zambiri kumayambiriro kwa chithandizo),
thupi lawo siligwirizana: pruritus, erythema, zotupa pa khungu (kuphatikizapo bulous ndi maculopapular zimachitikira), urticaria, matupi vasculitis, angioedema.

Zizindikiro zazikulu za hypoglycemia: kugona, kutopa, kupweteka mutu, chizungulire, kufooka, thukuta, mantha, paresthesia, kunjenjemera, kunjenjemera, nseru, kusanza. Mawonetsedwe otsatirawa ndiothekanso: kugona, kusokonezeka kwa tulo, kusokonezeka kwa kugona, kukwiya, kukwiya, kuyankhula komanso kusokonezedwa, kutsika pang'ono pang'ono, kusokonezeka, kusowa chidwi, kusokonezeka kwa malingaliro, paresis, aphasia, delirium, kulephera kudziletsa, kupweteka, bradycardia, kupuma pafupipafupi. , kukhumudwa, kulephera kudziwa. Hypoglycemia imatha kubweretsa kukomoka komanso kufa. Odwala ena amawonetsa zizindikiro za kuponderezana ndi adrenergic: thukuta, khungu losachedwa, kulumala, nkhawa, kuthamanga kwa magazi, angina pectoris, tachycardia, arrhasmia yamtima - izi zimakonda kutha mukamamwa chakudya.

Bongo

Ngati bongo wa bongo, hypoglycemia imayamba.

Kuti mumve zambiri, muyenera kuwonjezera kuchuluka kwa chakudya chamagulu mu chakudya, kuchepetsa kuchuluka kwa Gliclazide ndi / kapena kusintha kadyedwe. Mpaka pomwe zakhazikika kwathunthu, wodwalayo amayenera kuyang'aniridwa ndi achipatala.

Zovuta zakukula za hypoglycemic zimatha kutsagana ndi kupweteka, chikomokere ndi matenda ena amanjenje. Odwala oterowo amafuna chithandizo chamankhwala chodzidzimutsa, kuchipatala kumafunikira mwachangu.

Ngati chikomokere cha hypoglycemic chikukayikiridwa kapena kukhazikitsidwa, jekeseni wothandizidwa ndi 50 ml ya yankho la 20-30% ya dextrose (glucose). Kenako, kukayikira kwa 10% dextrose solution ndikofunikira kuti magazi a shuga apitirire 1 g / l. Masiku osachepera awiri amafunikira kuwunikira mosamala. Chithandizo chiyenera kutsagana ndi kuwunika ndikusamalira ntchito zofunika kwambiri za thupi.

Kutsegula m'mimba sikothandiza chifukwa gliclazide imamangilira kwakukulu mapuloteni a plasma.

Malangizo apadera

Kuti mupewe chiwopsezo cha kukomoka kwa hypoglycemic, dokotala amayenera kusankha mlingo wa Glyclazide, kum'patsa wodwalayo malangizo omveka bwino a mankhwalawo, ndikuwonetsetsa kuti akutsatira malangizowo.

Gliclazide imatha kuperekedwa kwa odwala omwe amatha kupereka chakudya nthawi zonse, kuphatikizapo chakudya cham'mawa. Kufunika kwa kudya kwa chakudya cham'mimba kumachitika chifukwa cha kuchuluka kwa vuto la hypoglycemia ngati chakudya chachedwa, chakudya chokwanira kapena kuchuluka kwa chakudya chambiri. Chiwopsezo cha hypoglycemia chimakula ndi chakudya chamagulu ochepa, kumwa mowa, kugwiritsa ntchito mankhwalawa kwa mankhwala angapo ochokera ku gulu la sulfonylurea, komanso ngati mungolimbitsa thupi kwa nthawi yayitali kapena mwamphamvu. Hypoglycemia ikhoza kukhala yokhazikika komanso yolimba, yomwe imafuna kuchipatala kwa wodwala ndikuwonetsa shuga kwa masiku angapo.

Hypoglycemia yayikulu ndikotheka kumwa mankhwala aliwonse a sulfonylurea. Odwala ofooka ndi opuwala, okalamba, odwala omwe ali ndi adrenal kusakwanira (onse oyambira komanso osachita sekondale) amatenga kwambiri.

Odwala ndi mabanja awo akuyenera kufotokozera kuwopsa kwa machitidwe a hypoglycemic, kufotokoza za zomwe akuwonetsa komanso njira zakuchiritsira, ndikufotokozeranso zomwe zikubweretsa kutsogoloku. Wodwala ayenera kumvetsetsa bwino kufunika kwa kudya, kuchita masewera olimbitsa thupi pafupipafupi komanso kuwunika kwamisempha yamagazi. Odwala omwe ali ndi matenda ashuga ayenera kuchenjezedwa za chiwopsezo chowonjezeka cha hypoglycemia ngati atafa ndi njala, kumwa zakumwa zoledzeretsa komanso mankhwala osapweteka a antiidal.

Zizindikiro za hypoglycemia nthawi zambiri zimatha kudya chakudya chamafuta ambiri, monga shuga. Zokoma sizikugwira ntchito. Ngakhale mpumulo woyambirira, hypoglycemia ikhoza kubwereranso. Ngati zizindikiro zazikulu kapena zazitali zazindikirika, ngakhale mutasintha pang'ono kwakanthawi ndi chakudya, mufunika chithandizo chamankhwala, kuphatikizira kuchipatala.

Mphamvu ya kayendetsedwe ka shuga m'magazi panthawi ya mankhwala othandizira odwala matenda a shuga imatha kuchepa motsogozedwa ndi zinthu zotsatirazi: kutentha thupi, matenda, opaleshoni, zoopsa, zovuta. Nthawi zina, kuyambitsa insulin kungafunike.

Kugwiritsa ntchito bwino kwa mapiritsi a Gliclazide, monga mankhwala ena aliwonse otsegula pakamwa, amachepetsa pakapita nthawi. Zomwe zimayambitsa izi zitha kukhala kupitilira kwa matenda ashuga kapena kufowoka komwe kumapangitsa mankhwalawo. Chodabwitsachi chimatchedwa kusowa kwachiwiri kwa zotsatira za mankhwala, mosiyana ndi kusowa kwenikweni kwa mphamvu kumayambiriro kwa mankhwalawa. Mapeto ake pakuchepa kwa mphamvu kungachitike pokhapokha mutasintha mosamala mlingo ndikuwonetsetsa kuti wodwala akutsatira zakudya.

Odwala omwe ali ndi vuto la glucose-6-phosphate dihydrogenase, mankhwala ochokera ku gulu la sulfonylurea, kuphatikizapo glycazide, angayambitse kuchepa kwa magazi m'thupi. Pankhani imeneyi, tikulimbikitsidwa kulingalira za kuthekera kwina kwa mankhwala omwe mungagwiritse ntchito ndi gulu lina kapena kugwiritsa ntchito Glyclazide mosamala kwambiri.

Pogwiritsa ntchito Gliclazide, ndikofunikira kuwunika ntchito za impso, chiwindi, mtima, komanso mawonekedwe a ophthalmic. Mukamayang'ana kuchuluka kwa shuga m'magazi, tikulimbikitsidwa kuyeza zomwe zili m'magazi a glycated hemoglobin (kapena glucose posala plousma yamagazi). Kuphatikiza apo, kudzipenda pawokha pakupanga glucose kumatha kukhala kopindulitsa kwa odwala.

Kukopa pa kuthekera koyendetsa magalimoto ndi njira zowerengeka

Gliclazide siyimakhudza kapena imakhudza pang'ono zochitika zama psychophysical za munthu. Komabe, munthawi yamankhwala, makamaka kumayambiriro kwa zamankhwala, oyendetsa magalimoto ndi anthu omwe amagwira ntchito m'mafakitori oopsa ayenera kusamala ndi chiopsezo cha hypoglycemia.

Mimba komanso kuyamwa

Pali owerengeka azachipatala pazokhudza kugwiritsa ntchito gliclazide pa nthawi yomwe ali ndi pakati. Pali chidziwitso pakugwiritsa ntchito kukonzekera kwina kwa sulfonylurea.

M'maphunziro a nyama, kupezeka kwa kawopsedwe wa kubereka poyerekeza ndi Mlingo wa gliclazide wapezeka.

Monga kusamala, mankhwalawa saloledwa kwa amayi apakati. Komabe, pofuna kupewa mapangidwe obadwa nawo mwa ana, kuyang'anira bwino matenda a shuga kwa amayi ndikofunikira. Omwe amamwa antidiabetesic sagwiritsidwa ntchito mwa amayi apakati, insulin ndiye mankhwala osankhidwa. Pokonzekera kutenga pakati komanso ngati kutenga pakati kumachitika mutamwa gliclazide, tikulimbikitsidwa kuti m'malo mwamankhwala omwe mumamwa pakhale insulin.

Sizikudziwika ngati mankhwalawa amalowera mkaka wa mayi, mogwirizana ndi izi, Glyclazide imayikidwa pakati pa mkaka wa mkaka.

Kuyanjana kwa mankhwala osokoneza bongo

Kugwiritsa ntchito kwa miconazole komwe kumachitika pakanthawi kochepa kapena mu mawonekedwe a gel kuti mugwiritse ntchito mucous nembanemba wamkamwa), chifukwa kumathandizira zotsatira za gliclazide ndipo, chifukwa chake, kumawonjezera chiopsezo cha hypoglycemia, mpaka kukomoka.

Osavomerezeka kuphatikiza:

phenylbutazone (mu mitundu yamagawo yogwiritsira ntchito): imawonjezera mphamvu ya hypoglycemic ya sulfonylureas. Mankhwala ena odana ndi kutupa amalimbikitsidwa. Ngati cholinga chophatikizira choterechi chili chokwanira, kuchuluka kwa shuga wamagazi kuyenera kuyang'aniridwa mosamala, ngati kuli kotheka, sinthani mlingo wa glycoslazide (ponseponse munthawi ya mankhwala komanso pambuyo poti muthana ndi phenylbutazone),
Mowa: Amakweza kwambiri hypoglycemia ndipo amatha kuyambitsa kukomoka.Panthawi yamankhwala, muyenera kusiya kumwa zakumwa zoledzeretsa ndikuyamba kumwa mankhwala okhala ndi Mowa,
danazol: ili ndi matenda ashuga; makulidwe ake sawavomerezeka pamankhwala a hypoglycemic. Komabe, ngati makonzedwe akufunika, mlingo wa Gliclazide uyenera kusinthidwa.

Kuphatikiza komwe kumafunikira kusamala:

othandizira ena a hypoglycemic (insulin, acarbose, biguanides), beta-blockers, angiotensin-akatembenuza enzyme inhibitors (enalapril, Captopril), fluconazole, histamine H blockers₂-receptors, sulfonamides, mankhwala osokoneza bongo a anti-yotupa, mankhwala ambiri a chlorpromazine, monoamine oxidase zoletsa: onjezerani zotsatira za hypoglycemic ndikuwonjezera chiopsezo cha hypoglycemia. Kusamala ka glycemic mosamala ndi kusankha kwa Gliclazide tikulimbikitsidwa.
tetracosactide, glucocorticosteroids a systemic and local (intraarticular, subcutaneous, cutaneous, rectal) gwiritsani ntchito: onjezani shuga wamagazi ndi chitukuko cha ketoacidosis (kuchepa kwa kulolera kwa chakudya chambiri). Kusamala kwambiri kwa glycemic ndikofunikira, makamaka kumayambiriro kwa hypoglycemic mankhwala, komanso kusintha kwa glycazide,
beta₂-adrenomimetics (terbutaline, salbutamol, ritodrine): kuwonjezera shuga wamagazi, kotero kuchuluka kwa shuga wamagazi kuyenera kuyang'aniridwa mosamala. Zitha kufunikira wodwala kupita ku insulin,
gliclazide ndi zotumphukira zina za sulfonylurea: ndikotheka kuwonjezera zochita za anticoagulants, zomwe zimafuna kusintha kwa mlingo.

Ndemanga za Gliclazide

Malinga ndi ndemanga, Gliclazide ndiwothandiza antidiabetes. Pakadali pano, zotumphukira za sulfonylureas zam'badwo wachiwiri zimagwiritsidwa ntchito kwambiri, chifukwa ndizopambana ndi m'badwo wam'mbuyomu mu hypoglycemic effect, ndipo ndizotheka kukwaniritsa zofananazo mukamapereka mankhwala ochepetsa. Kuphatikiza apo, ndalama za gululi ndizochepa zomwe zimayambitsa zovuta.

Akatswiri azachipatala akuwonetsa kuti panthawi ya biotransfform ya gliclazide, metabolite imapangidwanso, yomwe imakhala ndi phindu pa microcirculation. Kafukufuku wambiri watsimikizira kuti mankhwalawa amachepetsa chiopsezo cha microvascular complication (nephropathy, retinopathy), kukula kwa angiopathy. Kuphatikiza apo, imakonza zakudya za conjunctival, zimachotsa mtima stasis. Pankhani imeneyi, kusankha kwa Gliclazide ndizabwino kwambiri chifukwa cha zovuta za matenda a shuga monga kufooka kwa impso, nephropathy, retinopathy ndi angiopathy.

Pali malipoti akuti zaka zingapo (zaka 3-5) atayamba kumwa mankhwalawa, chidwi chamankhwala chimachepa. Zikatero, kuikidwa kwa wothandizira wa hypoglycemic ndikofunikira.

Mapiritsi a Glyclazide

Kukonzekera kwa hypoglycemic kukonzekera pakamwa, komwe ndi kotengera kwa m'badwo wachiwiri wa sulfonylurea, kumakhala ndi zotsatirapo zosiyanasiyana zochizira pamatenda. Glyclazide imapezeka mu mawonekedwe a mapiritsi a 80 mg kapena 30 ndi 60 mg ndi masinthidwe osinthidwa. Mankhwalawa atsimikizira kuti amagwira ntchito, motero, nthawi zambiri amadziwikiridwa kuti apange shuga m'magazi.

Mapiritsi a Glyclazide 30 mg ali ndi mawonekedwe ozungulira, osalala, okhala ndi chamfer, mtundu wake ndi woyera kapena pafupifupi woyera (wachikasu kapena wotuwa). Mlingo wa 60 mg uli pachiwopsezo. Zomwe zimagwiritsidwa ntchito ndi gliclazide. The mankhwala:

gliclazide-30 kapena 60 mg

silicon dioxide colloidal

sodium stearyl fumarate

Zizindikiro zogwiritsidwa ntchito

Mankhwala Gliclazide amagwiritsidwa ntchito kwambiri pa matenda a shuga 2 ndi hyperglycemia. Kulandila ndikofunikira makamaka pothana ndi njira yochepetsera kudya, njira yochepetsera ma index amthupi ndi masewera olimbitsa thupi. Glyclazide imathandiza kupewa mavuto a matenda a shuga 2: kukulitsa kwa ma cellvascular pathologies (stroke, myocardial infarction) ndi vuto la microcirculatory (retinopathy, nephropathy).

Malangizo ogwiritsira ntchito Gliclazide

Lingaliro la kukula kwa mlingo wovomerezeka ndi hyperglycemia limatsimikiziridwa pamaziko a magawo: msinkhu, zovuta za shuga, ndi shuga wamagazi musanadye ndi maola awiri mutatha kudya. Njira yoyamba yolimbikitsidwa ndi 40 mg ndi zakudya. Mlingo uwu umalimbikitsidwa kwa odwala onse, kuphatikizapo okalamba. Mlingo woyamba wa tsiku lililonse ndi 80 mg. Kupitilira apo, kutengera magawo, avareji ya 160 mg patsiku. Kusintha kwa Mlingo kumachitika poganizira nthawi yochepera milungu iwiri.

Mlingo woyenera wovomerezeka ndi - 320 mg. Ngati mungadumphe kumwa mankhwalawa, simuyenera kuwonjezera tsiku lotsatira. Mlingo wa odwala okalamba, komanso odwala matendawa, siwofanana. Kumwa mankhwalawa kuyenera kutsagana ndi kuyendetsa shuga m'magazi pofuna kupewa hypoglycemia (kuchuluka kwa glucose).

Glyclazide MV 30 mg

Mlingo wosinthika (MV) wa Gliclazide ukhoza kuyambira 30 mpaka 120 mg. Phwando limachitika m'mawa ndi chakudya. Ngati mungadumphe kumwa mankhwalawa a hyperglycemia, kubwezerera kumaletsedwa pochulukitsa mlingo tsiku lotsatira. Lingaliro la mlingo limapangidwa payekhapayekha. Mlingo woyambirira ndi 30 mg. Ngati zalephera pazotsatira, mlingo pang'onopang'ono (kamodzi pamwezi) umakwera mpaka 60, 90 ndi 120 mg. Gliclazide MB ikhoza kuphatikizidwa ndi insulin. Tiyerekeze kuti kusinthaku kungafanane kuchokera pa kutenga chakudya chapadera cha Gliclazide 80 kupita ku Gliclazide MV 30 mg pambuyo poti anthu ayike shuga.

Migwirizano yogulitsa ndikusunga

Mankhwalawa amayenera kusungidwa m'malo amdima osakhala chinyezi pa kutentha osaposa 25 digiri. Gliclazide iyenera kutetezedwa kwa ana. Moyo wa alumali ndi zaka zitatu. Yoperekedwa ndi mankhwala.

Mu msika wogulitsa mankhwala pamakhala zochitika zingapo za Gliclazide. Ena mwa iwo ali ndi chinthu chofanana, gawo lina limalola kuti zitheke. Mankhwala otsatirawa ndi fanizo la mankhwalawa:

Glyclazide Canon,
Glidia MV,
Gluconorm,
Gliklada
Zamakolo
Glucetam
Diabetes
Mdyerekezi
Dziwani.

Zotsatira zamtundu wa mankhwala

Hypoglycemic wothandizila pakamwa. Chochita chimapangidwa ngati zochokera m'badwo wachiwiri wa sulfonylurea. Imathandizira pakupanga insulin ndi maselo a pancreatic. Kuchulukitsa chidwi cha zotumphukira zimakhala kuti insulin. Kuchepetsa nthawi yatsalira pakati pa chakudya ndi kuyamba kwa insulin.

Mlingo ndi kapangidwe ka mapiritsi "Gliclazide"

Ikalowa m'mimba, mankhwalawo amawonongeka mofulumira. Pambuyo maola 4, 80 mg imalowa m'magazi ndi gawo limodzi la mankhwalawo. Pafupifupi 100% imaphatikizidwa ndi mapuloteni amwazi. Imasungunuka m'chiwindi ndikupanga ma metabolites omwe alibe katundu wa hypoglycemic, koma amangokhudza ma microcirculation. Amayamwa mkodzo masana.

Kumayambiriro kwa chithandizo, 80 mg imayikidwa kamodzi patsiku. Zambiri zitha kutengedwa 160-220 mg kawiri pa tsiku. Mapiritsi aledzera asanadye. Komanso, mankhwalawa amatengera njira ya matendawa komanso kuwonongeka kwa kapamba. Mutha kugawana nawo phwando. Piritsi limodzi limatengedwa pamimba yopanda kanthu, ndipo maola awiri mutatha kudya, bwerezani mlingo. Momwe mungagwiritsire ntchito "Glyclazide"? Malangizo ogwiritsira ntchito. Mtengo, analogues, mlingo woyenera - dokotala adzakuuzani zonse izi.

Kuchita ndi mankhwala ena

Mapiritsi a Glyclazide amawonongeka ngati atengedwa pamodzi ndi mankhwala ena. Izi ndi zotengera za pyrazolone, antibacterial sulfonamide, Mao inhibitors, theophylline, caffeine.

Ndi makonzedwe munthawi yomweyo ndi osagwiritsa ntchito beta-blockers, kusintha kwa hypoglycemia kumawonjezera, tachycardia ndi manja akunjenjemera, thukuta, makamaka usiku, lingaoneke.

Mukamagwiritsa ntchito mankhwala "Cimetidine" mu plasma, zomwe mapiritsi a "Gliclazide" amawonjezeka. Izi zimatha kudzetsa kwambiri hypoglycemia. Ndi makonzedwe omwewo a mapiritsi a Glyclazide ndi mankhwala a Veropomila, ndikofunikira kuwongolera msanga wamagazi.

Komanso potenga GCS, mapiritsi a Glyclazide amachepetsa katundu wawo wa hypoglycemic. Mankhwalawa amaphatikizapo diuretics, barbiturates, estrogens, ndi ena anti-TB. Chifukwa chake, ndikofunikira kuyeserera kwathunthu thupi musanamwe mankhwala "Gliclazide." Malangizo ogwiritsira ntchito, mtengo, analogi, zotsatira zoyipa - zonsezi ziyenera kudziwitsidwa pasadakhale.

Zisonyezo za kutenga mapiritsi a Glyclazide

Mankhwala amathandizidwa ndi matenda a shuga a mtundu wachiwiri wowopsa, pomwe pakadalibe insulin. Komanso njira zodzitetezera ku matenda a microcirculatory. Mankhwalawa amagwiritsidwa ntchito moyang'aniridwa ndi dokotala. Choyamba muyenera kuchita kuyezetsa magazi. Onetsetsani kuti mukutsatira zakudya mukamamwetsa mankhwala, muchepetseni kuchuluka kwa mchere komanso chakudya chamafuta. Kanani kutenga ufa ndi shuga.

Gliclazide mv

Mapiritsi a Glyclazide mv adzitsimikizira bwino. Malangizo ogwiritsira ntchito adzakuuzani za contraindication ndi zoyipa za mankhwalawa. Amagwiritsidwa ntchito pochiza matenda osokoneza bongo omwe samadalira insulin. Simungathe kumwa mankhwalawa matenda a shuga a mtundu woyamba, omwe ali ndi matenda a chiwindi ndi impso. Pa mimba ndi mkaka wa m`mawere, kumwa mankhwala koletsedwa.

Chithandizo chikuyenera kuyendera limodzi ndi shuga. Mwa zina zoyipa, kusanza, kusanza, kutsegula m'mimba, ndi kupweteka m'mimba. Nthawi zina, vuto la kuchepa magazi ndi leukopenia limayamba. Ndi vuto lililonse lokhudza zinthu zina za piritsi, zotupa zimatha kuoneka. Gliclazide mv ili ndi mitundu ingapo ya mankhwala osagwirizana. Awa ndi ma diuretics, barbiturates, estrogens, aminophylline mankhwala. Zachidziwikire, malangizo ogwiritsira ntchito ayenera kuphunziridwa musanayambe mankhwala ndi mapiritsi a Glyclazide mv. Mtengo wa malonda sapitilira ma ruble 500.

Oral hypoglycemic mankhwala. Mapiritsi oyera, kuwala pang'ono. Mbali zonse ziwiri pali zizindikiro za DIA 60. Izi zikusonyeza kuti mankhwalawo ndi ovomerezeka. Iyi ndi njira yabwino yothanirana ndi mankhwala achinyengo.

The zikuchokera mankhwala zikuphatikizapo zinthu gliclazide. Mankhwalawa amalembera achikulire okha. Muyenera kumwa piritsi limodzi kamodzi patsiku. Izi zimachitika nthawi ya chakudya cham'mawa. Kutengera mtundu wa matenda ashuga komanso momwe zinthu zilili, mlingo wake ungathe kuwonjezeredwa pamapiritsi awiri patsiku. Mapiritsi a Glyclazide ali ndi mtundu womwewo. Malangizo ogwiritsira ntchito amafotokozera chilichonse mwatsatanetsatane.

Mukamagwiritsa ntchito mlingo waukulu wa mankhwalawa, hypoglycemia imayamba. Pankhaniyi, ndikofunikira kupempha thandizo kwa katswiri. Ili ndi contraindication onse ofanana ndi zoyipa monga mankhwala a "Gliclazide mv". Malangizo ogwiritsira ntchito, mtengo, ndemanga - zonsezi zimayenera kuphunziridwa musanayambe chithandizo.

Ndemanga pa mankhwala "Gliclazide"

Nthawi zambiri, mumatha kumva zabwino zokhudza mapiritsiwo. Odwala amati mankhwalawo amathandizira kuwongolera shuga wamagazi ndipo amathandizira kukhala ndi thanzi labwino. Chokhacho chosokoneza ndichakuti mankhwalawa amayenera kumwa mosamalitsa malinga ndi chiwembucho. Mankhwala osokoneza bongo amatha kukhala owopsa.

Mtengo wa Gliclazide pama pharmacies

Kulembetsa mankhwalawo kwatha, ndiye kuti mtengo wa Gliclazide sukudziwika. Mtengo woyenerana ndi ma fanizo ena:

Gliclazide MV - rubles 115-144. Paketi iliyonse ya mapiritsi 60 a 30 mg aliyense,
Glidiab - 107-151 ma ruble. Paketi iliyonse ya mapiritsi 60 a 80 mg aliyense,
Diabeteson MV - 260-347 ma ruble. pa paketi iliyonse ya mapiritsi 30 a 60 mg.