PROTAFAN NM PENFill 100ME

Kuti muchepetse kuchuluka kwa shuga m'magazi, mankhwala amagwiritsidwa ntchito, omwe ndi othandiza kwambiri kuposa insulin. Mtundu woyamba wa matenda ashuga, kapamba akamalephera kupereka zofunikira za timadzi timeneti, insulin ndiye njira yokhayo yosungira thanzi ndi moyo wa odwala.

Insulin imayendetsedwa mosamalitsa monga adanenera dokotala komanso moyang'aniridwa ndi shuga. Kuwerengera kwa mlingo kumatengera chakudya chamagulu azakudya. Ndondomeko ya chithandizo imatsimikiziridwa payekhapayekha kwa wodwala aliyense ndipo zimatengera mbiri ya glycemic.

Kupanga kuchuluka kwa insulini pafupi ndi zachilengedwe, zazifupi, zapakati komanso zotenga nthawi yayitali zimagwiritsidwa ntchito. Ma insulin apakatikati akuphatikiza prepratrate yopangidwa ndi kampani yaku Danish Novo Nordisk - Protafan NM.

Kutulutsa Fomu ndi Kusungidwa kwa Protafan

Kuyimitsidwa kumakhala ndi insulin - isophan, ndiye kuti, insulin yaumunthu yopangidwa ndi mainjiniering.

Mu 1 ml muli 3.5 mg. Kuphatikiza apo, pali zokopa: zinc, glycerin, protamine sulfate, phenol ndi madzi a jakisoni.

Insulin Protafan hm yaperekedwa m'njira ziwiri:

1. Kuyimitsidwa kwa subcutaneous makonzedwe a 100 IU / ml 10 ml mu Mbale losindikizidwa ndi chivindikiro cha mphira, wokutira ndi aluminium othamangitsana. Botolo liyenera kukhala ndi kapu ya pulasitiki yoteteza. Mu phukusi, kuwonjezera pa botolo, pali malangizo ogwiritsa ntchito.
2. Protafan NM Penfill - makatoni amagalasi a hydrolytic, ophimbidwa ndi ma disc a rabara mbali imodzi ndi ma pisitoni a rabara mbali inayo. Kupangitsa kusakanikirana, kuyimitsidwa kumakhala ndi galasi lagalasi.
3. Kathumba kalikonse kamasungidwa mu cholembera chotuluka cha Flexpen. Phukusili lili ndi zolembera 5 ndi malangizo.

Mu botolo la 10 ml ya Protafan insulin muli 1000 IU, ndi cholembera cha 3 ml ya syringe - 300 IU. Mukayimirira, kuyimitsidwa kumapangidwira ndikukhala madzi amtambo komanso opanda khungu, kotero izi ziyenera kusakanizidwa musanagwiritse ntchito.

Kuti tisungidwe mankhwalawa, iyenera kuyikidwedwa pamafelemu apakati pa firiji, kutentha komwe kuyenera kupitilizidwa kuyambira madigiri 2 mpaka 8. Pewani kuzizira. Ngati botolo kapena cartridge Protafan NM Penfill yatsegulidwa, ndiye kuti imasungidwa kutentha, koma osati kuposa 25 ° C. Kugwiritsa ntchito insulin Protafan kuyenera kuchitika mkati mwa masabata 6.

Flexpen sichisungidwa mufiriji, kutentha kuti ukhalebe ndi zinthu zake zam'magazi sikuyenera kukhala kwapamwamba kuposa madigiri 30. Kuti muteteze kuchokera ku kuwala, chipewa chiyenera kuvalidwa pachigoba. Chogwirira chimayenera kutetezedwa ku mvula ndikuwonongeka kwa makina.

Imatsukidwa kuchokera kunja ndi thonje lothira kumowa, silingamizidwa m'madzi kapena kuthira mafuta, chifukwa izi zimaphwanya makina. Osadzazanso cholembera.

Kuyimitsidwa ndi mawonekedwe a penfill m'mak cartridge kapena zolembera zimaperekedwa kuchokera ku pharmacies ndi mankhwala.

Mtengo wa insulin mwa cholembera (Flexpen) ndiwokwera kuposa wa Protafan NM Penfill. Mtengo wotsika kwambiri wa kuyimitsidwa m'mabotolo.

Momwe mungagwiritsire ntchito Protafan?

Insulin Protafan NM imangoperekedwa kokha. Intravenous ndi intramuscular makulidwe ali osavomerezeka. Sichigwiritsidwa ntchito kuti mudzaze insulin. Onetsetsani kuti mwatsegula kapu yoteteza mukamagula mankhwala. Ngati iye kulibe kapena wosamasuka, musagwiritse ntchito insulin.

Mankhwalawa amawonedwa kuti ndi osayenera ngati malo osungirako aphwanyidwa kapena adagwidwa ndi madzi oundana, ndipo ngati atasakaniza samakhala wosabala - oyera kapena mitambo.

Subcutaneous makonzedwe a insulin amachitika kokha ndi insulin kapena cholembera. Mukamagwiritsa ntchito syringe, muyenera kuphunzira kuchuluka kwa magawo omwe mungachite. Kenako, mpweya umakokedwa kulowa mu syringe pamaso magawo a insulin yolimbikitsidwa. Ndikulimbikitsidwa kuti mupukutiritse vial yoyambitsa kuyimitsidwa ndi manja anu. Protafan imayambitsidwa pokhapokha kuyimitsidwa kwayamba kugwira ntchito.

Flexpen ndi cholembera chodzaza chomwe chimatha kutulutsa kuchokera ku 1 mpaka 60 mayunitsi. Amagwiritsidwa ntchito ndi singano za NovoFayn kapena NovoTvist. Kutalika kwa singano ndi 8 mm.

Kugwiritsa ntchito cholembera kumayendetsedwa molingana ndi malamulo awa:

• Chongani cholembera ndi kukhulupirika kwa cholembera chatsopano.
• Pamaso ntchito, insulin iyenera kukhala firiji.
• Chotsani kapu ndikusunthira chogwiriramo maulendo 20 kuti galasi lagalasi liyende limodzi ndi cartridge.
• M'pofunika kusakaniza mankhwalawo kuti akhale mitambo.
• Jakisanani ndi jakisoni wotsatira, muyenera kukweza chogwiririra kokwanira ka 10.

Pambuyo pokonzekera kuyimitsidwa, jakisoni imachitika nthawi yomweyo. Popanga yunifolomu kuyimitsidwa mu cholembera sayenera kuchepera 12 IU ya insulin. Ngati kuchuluka kofunikira kulibe, ndiye kuti tsopano pamagwiritsidwe ntchito yatsopano.

Pofuna kuphatikiza ndi singano, chomata chomata chimachotsedwa ndipo singanoyo imakwezedwa pa cholembera mwamphamvu. Kenako muyenera kuthyola chipewa chakunja, kenako chamkati.

Popewa thovu kuti lisalowe m'malo a jakisoni, piyani magawo awiri ndikusintha chosankha. Kenako yalowetsani singano ndikusewera cartridge kuti mutulutse thovu. Kanikizani batani loyambira njira yonse, pomwe osankhirayo akubwerera zero.

Ngati dontho la insulin likuwoneka kumapeto kwa singano, mutha kubaya. Ngati palibe dontho, sinthani singano. Mukasintha singano kasanu ndi kamodzi, muyenera kuletsa kugwiritsa ntchito chimberocho, popeza ndichoperewera.

Pofuna kukhazikitsa mlingo wa insulin, ndikofunikira kutsatira izi:

Mlingo wosankha wofikira ziro.

1. Tembenuzani chosankha mbali iliyonse kuti musankhe mlingo polumikiza ndi cholemba. Pankhaniyi, simungathe kukanikiza batani loyambira.
2. Tengani khungu lanu pang'onopang'ono ndikuyika singano m'munsi mwake pakulowa kwa madigiri 45.
3. Kanikizani batani la "Yambani" mpaka njira yonse kuti "0" iwoneke.
4. Pambuyo kuyikika, singano ikhale pansi pa khungu kwa masekondi 6 kuti mupeze insulini yonse. Mukachotsa singano, batani loyambira liyenera kuchitika.
5. Ikani chophimba pa singano ndipo pambuyo pake chimatha kuchotsedwa.

Sitikulimbikitsidwa kusunga Flexpen ndi singano, chifukwa insulin imatha kutayikira. Masingano ayenera kutayidwa mosamala, kupewa majekiseni mwangozi. Ma syringe onse ndi zolembera ndizongogwiritsa ntchito nokha.

Insulin yomwe imatenga pang'onopang'ono imayikidwa pakhungu la ntchafu, ndipo njira yofulumira kwambiri yolowera ilowa m'mimba. Kuti mupeze jakisoni, mutha kusankha gluteus kapena minofu ya m'mapazi.

Tsamba la jakisoni liyenera kusinthidwa kuti lisawononge mafuta osaneneka.

Cholinga ndi kumwa

Insulin imayamba kugwira ntchito maola 1.5 pambuyo pa utsogoleri, ikafika pakapita maola 4-12, ndipo amamuchotsa pakapita tsiku limodzi. Chizindikiro chachikulu pakugwiritsa ntchito mankhwalawa ndi matenda a shuga.

Kupanga kwa hypoglycemic zochita za Protafan kumalumikizidwa ndi kukhazikitsidwa kwa glucose m'maselo ndikusangalatsa kwa glycolysis kwa mphamvu. Insulin imachepetsa kuchepa kwa glycogen ndi mapangidwe a shuga m'chiwindi. Mothandizidwa ndi Protafan, glycogen imasungidwa m'malo osungirako minofu ndi chiwindi.

Protafan NM imayambitsa kaphatikizidwe ndi mapuloteni, kugawa kwamaselo, kumachepetsa kuwonongeka kwa mapuloteni, chifukwa chake zotsatira zake za anabolic zimawonekera. Insulin imakhudza minofu ya adipose, kuchepetsa kuchepa kwamafuta ndikuwonjezera mawonekedwe ake.

Amagwiritsidwa ntchito makamaka m'malo mwa chithandizo cha matenda a shuga a 1 omwe amadalira insulin. Pafupipafupi, amawonetsedwa kwa odwala amtundu wachiwiri panthawi ya kuchitira opaleshoni, kuyamwa kwa matenda opatsirana, panthawi yapakati.

Mimba, monga mkaka wa m`mawere, si kuphwanya kugwiritsa ntchito insulin iyi. Samadutsa placenta ndipo sangathe kufikira mwana ndi mkaka wa m'mawere. Koma pa mimba komanso mkaka wa m`mawere, muyenera kusankha mosamala ndi kusintha pafupipafupi mlingo wa glucose m'magazi.

Protafan NM ikhoza kutumikiridwa modziyimira payokha komanso kuphatikiza ndi insulin yofulumira kapena yochepa. Mlingo umatengera kuchuluka kwa shuga komanso kumva kukoma kwa mankhwalawa. Ndi kunenepa kwambiri komanso kutha msinkhu, pamatenthedwe okwera thupi amakhala apamwamba. Komanso kumawonjezera kufunika kwa insulin matenda a endocrine dongosolo.

Mlingo wosakwanira, kukana insulini kapena kusiya zomwe zimayambitsa hyperglycemia ndi zizindikiro zotsatirazi:

• Misozi imadzuka.
• Kuchepera kufooka.
• Kuyeserera kumachitika pafupipafupi.
• Kulakalaka kumachepa.
• Fungo la acetone lochokera mkamwa.

Zizindikirozi zimatha kuwonjezeka patangopita maola ochepa, shuga akapanda kuchepetsedwa, ndiye kuti odwala amatha kukhala ndi matenda a shuga a ketoacidosis, zomwe zimabweretsa zotsatira zoyipa, makamaka ndi matenda a shuga 1.

Zotsatira zoyipa za Protafan NM

Hypoglycemia, kapena kutsika kwa shuga m'magazi, ndi njira yovuta kwambiri komanso yowopsa yogwiritsira ntchito inulin. Imachitika ndi mlingo waukulu, kulimbitsa thupi, chakudya chosowa.

Miyezo ya shuga ikalipidwa, zizindikiro za hypoglycemia zimatha kusintha. Ndi chithandizo chazitali cha shuga, odwala amalephera kuzindikira kuyamba kwa shuga. Mankhwala omwe amagwiritsidwa ntchito kuti muchepetse kuthamanga kwa magazi, makamaka osasankha beta-blockers ndi ma tranquilizer, amatha kusintha zizindikiro zoyambirira.

Chifukwa chake, kuyesedwa pafupipafupi kwa misinkhu ya shuga kumalimbikitsidwa, makamaka sabata yoyamba kugwiritsa ntchito Protafan NM kapena mukasinthira kwa insulin ina.

Zizindikiro zoyambirira zochepetsa shuga m'magazi zitha kukhala izi:

1. Chizungulire mwadzidzidzi, mutu.
2. Kumva nkhawa, kusakhazikika.
3. Kuukira kwanjala.
4. Kutukwana.
5. Kutunda kwa manja.
6. Wofulumira komanso wowopsa mtima.

Woopsa milandu, ndi hypoglycemia chifukwa cha kusokonezeka mu ntchito ya ubongo, chisokonezo, chisokonezo chimayamba, chomwe chingapangitse kuti muwoneke.

Kuti tichotse odwala ku hypoglycemia mu milandu yofatsa, tikulimbikitsidwa kuti muthe shuga, uchi kapena shuga, msuzi wokoma. Potha kudziwa, 40% glucose ndi glucagon amalowetsedwa mu mtsempha. Kenako mumafunika chakudya chokhala ndi ma carbohydrate osavuta.

Ndi insulin tsankho, matupi awo sagwirizana zotupa, dermatitis, urticaria kumachitika, kawirikawiri anaphylactic mantha amachitika. Zotsatira zoyipa kumayambiriro kwa chithandizo zimatha kuwonetsedwa ndi kuphwanya kwa Refraction ndi kukula kwa retinopathy, kutupa, kuwonongeka kwa minyewa yamitsempha mu mawonekedwe amtundu wopweteka wa neuropathy.

Mu sabata yoyamba ya mankhwala a insulin, kutupa, thukuta, mutu, kusowa tulo, nseru, komanso kugunda kwa mtima kumawonjezereka. Mukazolowera mankhwalawa, zizindikirozi zimachepa.

Pakhoza kukhala kutupa, kuyabwa, redness, kapena kuvulala pamalo a jakisoni wa insulin.

Mlingo

Kuyimitsidwa kwa s / c kwamtundu woyera, ndikasakanikirana, kumapangika kukhala koyera komanso kopanda utoto kapena wopanda mawonekedwe, ndikusuntha, matope amayenera kuyambiranso

isofan insulin (umisiri wa majini a anthu) 100 IU *

Othandizira: zinc chloride, glycerol, metacresol, phenol, sodium hydrogen phosphate dihydrate, protamine sulfate, hydrochloric acid ndi / kapena sodium hydroxide solution (kukonza pH), madzi d / ndi.

* 1 IU imafanana ndi 35 μg ya insulin ya munthu wosafunikira.

Mankhwala

Protafan® NM Penfill® ndi kuyimitsidwa kosaloledwa kwa biosynthetic insulin yaumunthu, yopanga isofan-insulin.

Insulin yaumunthu yachilengedwe imapangidwa pogwiritsa ntchito ukadaulo wa DNA wogwiritsanso ntchito maselo a yisiti monga chinthu chotulutsa. Mankhwalawa ndi amodzi oyeretsa insulin ofanana ndi insulin ya anthu.

Mkati mwa chovala cha Penfill ® pali galasi lagalasi lomwe limagwiritsa ntchito mofananikira kuphatikiza tinthu tating'ono ta insulin. Mukatembenuza Penfill mmwamba kangapo, madziwo amakhala oyera ndikusintha yunifolomu.

Mbiri yakuchitapo kanthu kwa jakisoni wotsekemera (ziwerengero):

isanayambike pambuyo maola 1.5, mphamvu yayikulu: kuchokera 4 mpaka 12 maola, nthawi yochita: maola 24.

Zogulitsa

- wodwala matenda a shuga ogwirizana ndi insulin (mtundu I),

- osagwirizana ndi insulin - wodwala matenda a shuga (mtundu II): gawo la kukana kwa othandizira am'magazi a hypoglycemic, kukana pang'ono kwa mankhwalawa (panthawi yophatikiza mankhwala), matenda omwewo, ntchito, pakati

Kuyanjana kwa mankhwala osokoneza bongo

Pali mankhwala angapo omwe amakhudza kufunika kwa insulin. Chifukwa chake, ngati mukumwa mankhwala aliwonse, funsani dokotala.

• Mutha kugula katemera wa Protafan nm 100me / ml 3ml n5 ku Moscow m'chipatala chomwe mungakwanitse poika oda pa Apteka.RU.
• Mtengo wa Protafan nm penfill 100me / ml 3ml n5 makatoni ku Moscow ndi 800.00 rubles.
• Malangizo ogwiritsira ntchito katoni ya Protafan nm 100me / ml 3ml n5.

Mutha kuwona malo operekera pafupi ndi Moscow kuno.

Mitengo ya Protafan Nm m'mizinda inanso

Mlingo wa mankhwalawa umayikidwa ndi dokotala payekhapayekha. Mankhwalawa amagwiritsidwa ntchito pokhapokha pobayira jakisoni. Pambuyo pa jekeseni, singano imayenera kukhalabe pansi pakhungu kwa masekondi angapo, yomwe imawonetsetsa kuti pali mlingo wokwanira.

Pankhani ya matenda a shuga omwe amadalira insulin (mtundu I), mankhwalawa amagwiritsidwa ntchito ngati insal insulin limodzi ndi insulin yokonzekera.

Pogwiritsa ntchito matenda osokoneza bongo a shuga osagwirizana ndi insulin (mtundu II), mankhwalawa amatha kugwiritsidwa ntchito ngati monotherapy komanso kuphatikiza ndi ma insulin othamanga.

Mukasamutsa wodwala kuchokera ku nkhumba yotsukidwa kwambiri kapena insulin yaumunthu kupita ku Protafan NM Penfill, mlingo wa mankhwalawo amakhalabe womwewo.

Mukasamutsa kuchokera ku ng'ombe kapena insulin yosakanizidwa kupita ku Protafan NM Penfill, mlingo uyenera kuchepetsedwa ndi 10%, pokhapokha ngati koyamba mlingowo ndi wochepera 0,6 U / kg thupi.

Pa mlingo wa tsiku ndi tsiku wopitilira 0,6 U / kg, insulin iyenera kuperekedwa monga majekeseni awiri kapena angapo m'malo osiyanasiyana

Zochita Zamankhwala

The munthawi yomweyo mankhwala angapangitse insulin. Izi zikuphatikizapo monoamine oxidase inhibitors (Pyrazidol, Moclobemide, Silegilin), antihypertensive mankhwala: Enap, Kapoten, Lisinopril, Ramipril.

Komanso, kugwiritsa ntchito bromocriptine, anabolic steroids, Colfibrate, Ketoconazole ndi Vitamini B6 kumawonjezera chiopsezo cha hypoglycemia ndi mankhwala a insulin.

Mankhwala a Hormonal ali ndi vuto lina: glucocorticosteroids, mahomoni a chithokomiro, njira zakulera zam'mlomo, antidepressants atatu ndi thiazide diuretics.

Kuwonjezeka kwa mlingo wa insulini kungafunike polemba Heparin, calcium blockers, Danazole ndi Clonidine. Kanemayo munkhaniyi aperekanso zambiri za Protofan insulin.

Protafan insulin: kufotokozera, malingaliro, mtengo

Insulin Protafan amatanthauza insulin ya anthu wamba.

Kufunika kugwiritsa ntchito mankhwala a Insulin Protafan HM Penfill kumatha kuchitika ndi matenda osiyanasiyana. Choyamba, ndi matenda amtundu wa 1 ndi mtundu 2. Kuphatikiza apo, mankhwalawa akuwonetsedwa pa gawo la kukana mankhwala oyamba a hypoglycemic.

Mankhwalawa amagwiritsidwanso ntchito pamodzi ndi mankhwala ophatikizidwa (kusungidwa kwina kwa mankhwala opaka pakamwa), ngati matenda a shuga apezeka mwa amayi apakati ndipo ngati chithandizo cha zakudya sichithandiza,

Matenda apakati ndi othandizira kuchitapo kanthu (ophatikizidwa kapena monotherapy) amathanso kukhala chifukwa choikidwiratu.

Zolemba za mankhwala

Mankhwala ndi kuyimitsidwa komwe kumayambitsidwa pansi pa khungu.

Gulu, ntchito:

Isulin insulin-human semisynthetis (semisynthetisita wa anthu). Ili ndi nthawi yayitali yochitapo kanthu.Protafan NM imaphatikizidwa mu: insulinoma, hypoglycemia ndi hypersensitivity pazomwe zimagwira.

Kodi mutenge ndi kumwa bwanji?

Insulin imalowetsedwa kamodzi kapena kawiri patsiku, theka la ola musanadye chakudya cham'mawa. Pankhaniyi, momwe ma jakisoni amapangidwira, ayenera kusinthidwa nthawi zonse.

Mlingo uyenera kusankhidwa kwa wodwala aliyense payekhapayekha. Kuchuluka kwake kumadalira kuchuluka kwa shuga mumkodzo ndi magazi, komanso machitidwe a matendawa. Kwenikweni, mlingo umayikidwa 1 nthawi patsiku ndipo ndi 8-24 IU.

Mu ana ndi akulu omwe ali ndi hypersensitivity kupita ku insulin, kuchuluka kwa mlingo kumachepetsedwa mpaka 8 IU patsiku. Ndipo kwa odwala omwe ali ndi vuto lotsika, madokotala omwe akupezekapo amatha kukupatsani mankhwala okwanira 24 IU patsiku. Ngati mlingo wa tsiku ndi tsiku umaposa 0,6 IU pa kg, ndiye kuti mankhwalawa amaperekedwa ndi jakisoni awiri, omwe amachitika m'malo osiyanasiyana.

Odwala omwe amalandira 100 IU kapena kuposerapo patsiku, amasintha insulin, ayenera kuyang'aniridwa ndi madokotala nthawi zonse. Kusintha mankhwalawo ndi kwina kuyenera kuchitika ndikuwunikira kuchuluka kwa shuga m'magazi.

Mankhwala

Malo a Insulin Protafan:

• amachepetsa shuga
• kusintha kuthekera kwa glucose m'misempha,
• zimathandizira pakupanga mapuloteni abwino,
• amachepetsa kuchuluka kwa shuga ndi chiwindi,
• timapitilira glycogenogeneis,
• Amachita bwino mauxos.

Microinteraction ndi ma receptors kumtundu wakunja kwa cell imalimbikitsa kupangidwe kwa insulin receptor tata. Mwakukondoweza m'maselo a chiwindi ndi maselo amafuta, kapangidwe kake ka msasa kapena kulowa mkati mwa minofu kapena khungu, insulin receptor tata imayambitsa zomwe zimachitika mkati mwa maselo.

Zimayambanso kaphatikizidwe kazinthu zina zazikulu za michere (glycogen synthetase, hexokinase, pyruvate kinase, ndi zina).

Kutsika kwa shuga m'magazi kumayambitsidwa ndi:

• kuchuluka kwa shuga m'magazi,
• kukondoweza kwa glycogenogeneis ndi lipogenesis,
• kuchuluka mayamwidwe ndi glucose minofu,
• mapuloteni kaphatikizidwe
• kutsika kwa kuchuluka kwa shuga omwe amapangidwa ndi chiwindi, i.e. kuchepa kwa kuwonongeka kwa glycogen ndi zina.

Zotsatira zoyipa

Hypoglycemia (mawonekedwe amisala ndi kuyankhula, kutsekeka kwa khungu, kusunthika kwakasunthidwe, kuchuluka kwa thukuta, zachilendo. ,

Thupi lawo siligwirizana (kutsika magazi, urticaria, kupuma movutikira, malungo, angioedema),

Kuwonjezeka kwa gawo la anti-insulin antibodies ndikuwonjezereka kwa glycemia,

Diabetesic acidosis ndi hyperglycemia (motsutsana ndi matenda ndi kutentha thupi, kusowa kwa chakudya, jakisoni wochepa, milingo yocheperako): kupukusa nkhope, kugona, kusowa chilala, ludzu losalekeza,

Pa gawo loyambirira la zamankhwala - zolakwika zolimbitsa thupi ndi edema (chinthu chosakhalitsa chomwe chimachitika ndi chithandizo chinanso),

Kusokonezeka kwa chikumbumtima (nthawi zina kumakhala kukomoka komanso mawonekedwe a precomatose),

Patsamba la jakisoni, kuyabwa, hyperemia, lipodystrophy (hypertrophy kapena atrophy ya subcutaneous fat),

Kumayambiriro kwa chithandizo chamankhwala ndimwadzidzidzi,

Kuphatikizana kwa zamankhwala ndi insulin yaumunthu.

• kukokana
• thukuta
• hypoglycemic coma,
• kugunda kwa mtima
• kusowa tulo
• masomphenya komanso kulankhula,
• kunjenjemera
• mayendedwe osokonekera
• kugona
• kulakalaka
• machitidwe achilendo
• nkhawa
• kusakhazikika
• paresthesia pamkamwa,
• kukhumudwa
• womvera
• mantha
• mutu.

Kodi kuchitira bongo?

Ngati wodwalayo ali ndi vuto lakelo, ndiye kuti dokotala amakupatsani mankhwala a dextrose, omwe amaperekedwa kudzera mwa dontho la magazi, kudzera m'mitsempha kapena m'mitsempha. Glucagon kapena hypertonic dextrose solution imayendetsedwanso kudzera m'mitsempha.

Ngati chitukuko cha kuperewera kwa hypoglycemic, 20 mpaka 40 ml, i.e. 40% dextrose yankho mpaka wodwala atatuluka chikomokere.

1. Musanatenge insulini phukusi, muyenera kuwona kuti yankho mu botolo ili ndi mtundu wowonekera. Ngati kusefukira, matenthedwe kapena matupi akunja kumaoneka, yankho limaletsedwa.
2. Kutentha kwa mankhwala musanakhazikitsidwe kuyenera kukhala kutentha kwa chipinda.
3. Pamaso pa matenda opatsirana, kuvuta kwa chithokomiro, matenda a Addiosn, kulephera kwa impso, hypopituitarization, komanso odwala matenda ashuga okalamba, mlingo wa insulin umayenera kusinthidwa payekhapayekha.

Zomwe zimayambitsa hypoglycemia zitha kukhala:

• bongo
• kusanza
• kusintha kwa mankhwala
• matenda omwe amachepetsa kufunika kwa insulin (matenda a chiwindi ndi impso, hypofunction ya chithokomiro, pituitary gland, adrenal cortex),
• kusasamala kudya zakudya,
• mogwirizana ndi mankhwala ena
• kutsegula m'mimba
• kuchulukitsa kwakuthupi,
• kusintha kwa jekeseni.

Posamutsa wodwala kuchokera ku insulin ya nyama kupita ku insulin yaumunthu, kuchepa kwa shuga m'magazi kungaoneke. Kusintha kwa insulin yaumunthu kuyenera kuvomerezeka kuchokera ku malingaliro azachipatala, ndipo akuyenera kuchitika moyang'aniridwa ndi dokotala.

Nthawi yobadwa komanso yobereka, kufunika kwa insulini kumatha kuchepetsedwa kwambiri. Pa mkaka wa m`mawere, muyenera kuwunika amayi anu kwa miyezi ingapo, mpaka kufunika kwa insulin kukhazikika.

Kuwona kwa kupitirira kwa hypoglycemia kungayambitse kuwonongeka kwa munthu wodwala kuyendetsa magalimoto ndikukhala ndi makina ndi makina.

Mothandizidwa ndi shuga kapena chakudya chamafuta ambiri, odwala matenda ashuga amatha kuyimitsa mtundu wofatsa wa hypoglycemia. Ndikofunika kuti wodwalayo nthawi zonse amakhala naye 20 g shuga.

Ngati hypoglycemia yayimitsidwa, ndikofunikira kudziwitsa dokotala yemwe apange chithandizo.

Pa nthawi ya pakati, kuchepa (1 trimester) kapena kuwonjezeka (trimesters 2-3) kwa thupi kufunikira kwa insulin kuyenera kuganiziridwanso.

Kuchita ndi mankhwala ena

• Mao inhibitors (selegiline, furazolidone, procarbazine),
• sulfonamides (sulfonamides, mankhwala a hypoglycemic mkamwa),
• NSAIDs, ACE zoletsa ndi salicylates,
• anabolic steroids ndi methandrostenolone, stanozolol, oxandrolone,
• kaboni anhydrase zoletsa,
• Mowa
• androgens
• chloroquine
• bromocriptine
• quinine
• manzeru
• quinidine
• clofribate
• pyridoxine
• ketoconazole,
• Kukonzekera kwa Li +,
• mebendazole,
• theofylline
• fenfluramine,
• cyclophosphamide.

1. Ma blockers a H1 - vitamini receptors,
2. glucagon,
3. epinephrine
4. somatropin,
5. phenytoin
6. GKS,
7. chikonga
8. kulera kwamlomo
9. chamba
10. estrogens
11. morphine
12. loop ndi thiazide okodzetsa,
13. diazoxide
14. BMKK,
15. odana ndi calcium
16. mahomoni a chithokomiro,
17. clonidine
18. heparin
19. mankhwala antidepressants,
20. sulfinpyrazone
21. danazol
22. amphanomachul.

Palinso mankhwala omwe amatha kufooketsa komanso kuwonjezera mphamvu ya insulin. Izi zikuphatikiza:

• pentamidine
• beta blockers,
• octreotide
• yotsalira.

Protafan nm penfill - malangizo, gwiritsani ntchito, mtengo, ndemanga

Protafan NM Penfill ndi othandizira omwe amathandiza pochiza matenda a shuga. Mankhwalawa, akamagwiritsidwa ntchito moyenera, amakulolani kutsata kuchuluka kwa shuga m'magazi, osavulaza thanzi la wodwalayo.

Dzinalo Losayenerana

A.10.A.C - insulins ndi mawonekedwe awo ofanana ndi nthawi yayitali yochitapo kanthu.

Kuyimitsidwa kwa subcutaneous makonzedwe a 100 IU ml amapezeka mu mawonekedwe a: botolo (10 ml), cartridge (3 ml).

The 1 ml ya mankhwala muli:

1. Zosakaniza: yogwira insulin-isophan 100 IU (3.5 mg).
2. Zothandiza: glycerol (16 mg), zinc chloride (33 μg), phenol (0.65 mg), sodium hydrogen phosphate dihydrate (2.4 mg), protamine sulfate (0.35 mg), sodium hydroxide (0,4 mg ), metacresol (1.5 mg), madzi a jakisoni (1 ml).

Kuyimitsidwa kwa subcutaneous makonzedwe a 100 IU ml amapezeka mu mawonekedwe a: botolo (10 ml), cartridge (3 ml).

Zotsatira za pharmacological

Zimatanthauzira othandizira a hypoglycemic okhala ndi nthawi yayitali yochitapo kanthu. Amapangidwa ndi ukadaulo wama DNA ogwiritsidwanso ntchito ngati Saccharomyces cerevisiae. Imakhudzana ndi ma membrane receptors, ndikupanga insulini-receptor zovuta zomwe zimapangitsa kuti kapangidwe kazinthu kamene kamakhala ndi moyo (hexokinases, glycogen synthetases).

Mankhwalawa amathandizira kuyendetsa mapuloteni kudzera m'maselo a thupi. Zotsatira zake, kukweza kwa glucose kumapangidwira bwino, lipo- ndi glycogeneis imalimbikitsidwa, ndipo kupanga shuga kwa chiwindi kumachepetsedwa. Kuphatikiza apo, mapuloteni amaphatikizidwa.

Pharmacokinetics

Mphamvu ya mankhwalawa komanso kuthamanga kwa kutsekeka kwake kumatsimikiziridwa ndi Mlingo, malo oyendetsera, njira ya jakisoni (subcutaneous, intramuscular), insulini yodwala. Zokwanira zomwe zimakhala m'magazi zimafikiridwa pambuyo pa maola 3-16 pambuyo pobayira jekeseni.

Momwe mungatenge Protafan NM Penfill?

Chitani jakisoni wamkati kapena subcutaneous. Mlingo wake umasankhidwa potengera mawonekedwe ndi matendawo. Kuchuluka kwovomerezeka kwa insulin kumasiyana pakati pa 0.3-1 IU / kg / tsiku.

Insulin imalowetsedwa ndi cholembera. Anthu omwe ali ndi insulin kukana amakhala ndi kuchuluka kwa insulini (panthawi ya chitukuko cha kugonana, kulemera kwambiri kwa thupi), motero, amapatsidwa mlingo waukulu.

Kuti muchepetse chiopsezo cha lipodystrophy, ndikofunikira kusintha malo a mankhwala. Kuyimitsidwa, molingana ndi malangizo, ndizoletsedwa kulowa intraral.

Ndi matenda ashuga

Protafan imagwiritsidwa ntchito pa mtundu uliwonse wa matenda ashuga. Njira yochizira imayamba ndi matenda a shuga 1. Mankhwala 2 amalembedwa ngati palibe zotsatira kuchokera ku mankhwala a sulfonylurea, panthawi yomwe ali ndi pakati, panthawi yomwe akuchitidwa opaleshoni, komanso ma pathologies omwe amaphatikizana ndi zovuta za matenda ashuga.

Zotsatira zoyipa za Protafan NI Penfill

Zochitika zoyipa zomwe zimawoneka mu odwala panthawi ya chithandizo chamankhwala zimayambitsidwa chifukwa cha mankhwala osokoneza bongo ndipo zimagwirizanitsidwa ndi pharmacological zochita za mankhwala. Mwa zina zomwe zimachitika kawirikawiri, hypoglycemia imadziwika. Chimawonekera chifukwa chosagwirizana ndi mlingo wa insulin.

Mu hypoglycemia yayikulu, kusazindikira, kukhudzika, kusokonezeka kwa ubongo, ndipo nthawi zina kufa, ndizotheka. Nthawi zina, pali kuphwanya kwa chakudya chamafuta.

Pa mbali ya chitetezo chamthupi ndi zotheka: zidzolo, urticaria, thukuta, kuyabwa, kupuma movutikira, vuto la mtima, kuchepa kwa kuthamanga kwa magazi, kusazindikira.

Pa chitetezo chamthupi, zotsatira zoyipa ndizotheka: zotupa, urticaria, kuyabwa.

Mchitidwe wamanjenje ulinso pachiwopsezo. Nthawi zina, zotumphukira neuropathy zimachitika.

Malangizo apadera

Mlingo wosankhidwa mosayenera kapena kuchotsedwa kwa mankhwalawa kumayambitsa hyperglycemia. Zizindikiro zoyambirira zimayamba kuonekera patatha maola ochepa kapena masiku. Ngati thandizo siliperekedwa munthawi yake, chiopsezo chokhala ndi matenda ashuga a ketoacidosis, omwe amakhudza kwambiri moyo wa munthu, amawonjezeka.

Ndi ma concomitant pathologies omwe amawonetsedwa ndi kutentha kapena matenda opatsirana, kufunikira kwa insulin mwa odwala kumawonjezeka. Ngati ndi kotheka, sinthani mulingo womwe ungasinthidwe panthawi ya jakisoni woyamba kapena ndi chithandizo china.

Gwiritsani ntchito mu ukalamba

Odwala mpaka zaka 65 sakhala ndi zoletsa kumwa mankhwalawa. Pofika msinkhu uno, odwala ayenera kuyang'aniridwa ndi adokotala ndikuwunika zinthu zokhudzana ndi izi.

Itha kugwiritsidwa ntchito kwa ana ochepera zaka 18. Mlingo wakhazikitsidwa payekha pamaziko a kafukufukuyu. Nthawi zambiri amagwiritsidwa ntchito mu mawonekedwe a madzi.

Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere

Kugwiritsidwa ntchito pa nthawi yoyembekezera, monga samadutsa placenta. Ngati matenda a shuga sagwiritsidwa ntchito nthawi yakhazikitsidwa, chiopsezo kwa mwana wosabadwayo chikukula.

Hypoglycemia yovuta imachitika ndi njira yosankhidwa yosasankhidwa bwino, yomwe imawonjezera chiopsezo cha zolakwika mwa mwana ndikumuwopseza kuti adzafa ndi intrauterine. Mu trimester yoyamba, kufunika kwa insulin kumakhala kotsika, ndipo mu 2 ndi 3 kumawonjezeka. Pambuyo pobereka, kufunika kwa insulini kumakhala chimodzimodzi.

Mankhwalawa si owopsa poyamwitsa. Nthawi zina, kusintha kwa jekeseni kapena zakudya kumafunika.

Mankhwala ochulukirapo a Protafan NI Penfill

Mlingo wobweretsa mankhwala osokoneza bongo sunadziwika. Kwa wodwala aliyense, poganizira momwe nthendayo imakhalira, pali mlingo waukulu, womwe umatsogolera ku mawonekedwe a hyperglycemia.

Ndi hypoglycemia yofatsa, amatha kupirira nayo payekha pakudya zakudya zotsekemera ndi zakudya zokhala ndi chakudya chamagulu ambiri.

Sizopweteka kukhala ndi maswiti pamanja, ma cookie, misuzi ya zipatso kapena chidutswa cha shuga.

Mitundu yayikulu (kusazindikira), yankho la glucose (40%) imalowetsedwa mu mtsempha, 0,5-1 mg wa glucagon pansi pa khungu kapena minofu. Munthu akakhala ndi chidwi, kuti apewe kuyambika, amapatsa chakudya chamoto chambiri.

Zosungidwa zamankhwala

Mankhwalawa ayenera kusungidwa m'malo abwino komanso amdima pa kutentha kwa + 2 ... + 8 ° C (akhoza kuyikidwa mufiriji, koma osati mufiriji). Sichikhala ndi kuzizira. Katiriji amayenera kusungidwa mu phukusi lake kuti atetezeke ku dzuwa.

Katoni yomwe idatsegulidwa imasungidwa pa 30 ° C kwa masiku osaposa 7. Osasunga mufiriji. Kuletsa ana kuti azilankhula.

Wopanga

NOVO NORDISK, A / S, Denmark

Protafan insulin: kufotokozera, malingaliro, mtengo

Protafan Human Protulin Analogue

Svetlana, wazaka 32, Nizhny Novgorod: "Ndikakhala woyembekezera ndimagwiritsa ntchito Levemir, koma hypoglycemia imawonekera. Dokotala yemwe adalipo adalimbikitsa kusintha majekeseni a Protafan NM Penfill. Vutoli lakhazikika, mavuto obwera pambuyo ponsepo ngakhale kuti sanawone. "

Konstantin, wazaka 47, Voronezh: “Kwa zaka 10 tsopano ndayamba kudwala matenda a shuga. Nthawi yonseyi sindinathe kudzisankhira mtundu woyenera wa mankhwala a glucose m'magazi. Miyezi isanu ndi umodzi yokha yapitayo ndidagwiritsa ntchito jakisoni wa Prescript Protafan NM Penfill ndipo ndikusangalala ndi zotsatira zake. Mavuto onse omwe amakumana nawo poyamba samadzipatsanso chiyembekezo. Mtengo wotsika mtengo. ”

Valeria, wazaka 25, ku St. Petersburg: “Ndakhala ndikudwala matenda ashuga kuyambira ndili mwana. Ndayesa mankhwala opitilira 7, ndipo palibe omwe anakhutira. Mankhwala omaliza omwe ndidagula monga adalangizidwa ndi dokotala anga anali kuyimitsidwa kwa Protafan NM Penfill.

Mpaka posachedwa, ndimakayikira momwe zimagwirira ntchito ndipo sindinkakhulupirira kuti zinthu zidzasintha. Koma adawona kuti mawonekedwe a hypoglycemia asiya kusokonekera, thanzi lonse silinali lachilendo. Ndimagula m'mabotolo.

Malonda ake ndi osavuta kugwiritsa ntchito komanso ndi okwera mtengo. ”

Protafan - malangizo atsatanetsatane ogwiritsira ntchito

Matenda a shuga amatanthauza matenda osakhazikika omwe amakhudza ziwalo zonse. Njira zazikulu zachitukuko zimagwirizanitsidwa ndi kuchepa kwa insulin ya mahomoni, yomwe imayang'anira kugwiritsa ntchito shuga ndi maselo. Zotsatira zake, pali kusalinganika mu metabolism, kuchuluka kwa glucose m'magazi kumakwera. Chithandizo cha matenda osokoneza bongo chimatupa mpaka kukonzanso kwa mahomoni amoyo wonse.

Mzere wonse wa ma insulin opanga wakonzedwa. M'modzi mwa iwo ndi Protafan. Malangizo ogwiritsira ntchito ali ndi chidziwitso chonse chofunikira chothandizira pakudziyimira pawokha pakufunika kwa mankhwalawa.

Kupanga ndi mawonekedwe a kumasulidwa

Zomwe zimagwira ndi insulin yaumunthu, yopangidwa ndi maukadaulo opanga ma genetic engineering. Amapezeka mumitundu yambiri:

1. "Protafan NM": Ichi ndi kuyimitsidwa kwa mbale, 10 ml iliyonse, insulin ndende ya 100 IU / ml. Phukusili lili ndi botolo limodzi.
2. Protafan NM Penfill: makatoni okhala ndi 3 ml (100 IU / ml) iliyonse. Mu chithuza chimodzi - makatoni 5, phukusi - 1 matuza.

Omwe amathandizira: madzi a jakisoni, glycerin (glycerol), phenol, sodium hydrogen phosphate dihydrate, protamine sulfate, metacresol, sodium hydroxide ndi / kapena hydrochloric acid (kusintha pH), zinc chloride.

Mfundo zakugwiritsa ntchito Protafan

Mankhwalawa amagwiritsidwa ntchito pa mtundu uliwonse wa matenda ashuga. Mtundu Woyamba, chithandizo chimayambira pomwepo, mwachitsanzo II, Protafan akuwonetsedwa pazochitika za sulfonylurea zotumphukira, panthawi yoyembekezera, panthawi yomwe akuyamba kugwira ntchito, pamaso pa matenda ophatikizana ndi matenda a shuga.

Clinical Pharmacology

Kukhazikika kwa chojambulidwa kwadulidwa maola 1.5 pambuyo panjira ya subcutaneous. Zochita bwino - pambuyo maola 4-12. Kutalika konse kwa maola 24.

Ma pharmacokinetics amatsimikiza mfundo zomwe amagwiritsa ntchito "Protafan":

1. Matenda a shuga omwe amadalira insulini - monga chida chofunikira kuphatikiza ndi ma insulin osakhalitsa.
2. Mellitus wosadalira insulin - monotherapy ndi wothandizira uyu amaloledwa, komanso kuphatikiza ndi mankhwala omwe amagwira ntchito mwachangu.

Ngati mankhwalawa agwiritsidwa ntchito ngati chithandizo cha mono, amandidulira musanadye. Kugwiritsa ntchito koyamba, kutumikiridwa kamodzi patsiku (m'mawa kapena madzulo).

Funso loti ngati Protafan angafalitsidwe nthawi zambiri limakhala ndi yankho loipa; izi nthawi zonse zimakhala maziko othandizira matenda omwe sangathe kugawidwa nawo.

Njira yogwiritsira ntchito

Mankhwalawa amapaka pakhungu. Malo achikhalidwe ndi malo m'chiuno. Zilonda zimaloledwa m'dera lakhoma lamkati, matako, ndi minofu yolumikizira mkono. Malowo a jekeseni ayenera kusinthidwa kuti aletse kukula kwa lipodystrophy. Ndikofunikira kukoka khungu kuti mupewe kulowetsamo insulin.

Zofunika! Intravenous makonzedwe a insulini ndi kukonzekera kwake ndi koletsedwa kulikonse.

Njira yogwiritsira ntchito cholembera cholembera insulin "Protafan"

Kukhazikika kwakanthawi kokhazikika kwa mitundu ya jakisoni kumafuna kusinthitsa njirayi momwe ndingathere. Pachifukwa ichi, cholembera cha syringe chapangidwa, chomwe chimakwezedwa ndi ma cartridges a Protafana.

Wodwala aliyense yemwe ali ndi matenda ashuga ayenera kudziwa momwe angagwiritsire ntchito ndi mtima:

• Musanatsirize cartridge, fufuzani ma CD kuti muwonetsetse kuti mulondola.
• Onetsetsani kuti mukuyang'ana cartridge nokha: ngati pali kuwonongeka kulikonse kapena kuwonekera pakati pa tepi yoyera ndi piston yoyikira, ndiye kuti izi sizigwiritsidwa ntchito.
• Ulusi wa mphira umachiritsidwa ndi mankhwala ogwiritsa ntchito ngati thonje.
• Asanakhazikitse cartridge, kachitidweko kamapumidwa. Kuti muchite izi, sinthani mawonekedwe kuti galasi lagalasi mkati likusuntha kuchokera mbali ina kupita kwina nthawi zosachepera 20. Zitatha izi, madziwo amafunika kukhala amtambo.
• Makatoni okha omwe ali ndi magawo 12 a insulin omwe amafunika kusakanikirana malinga ndi njira yomwe tafotokozayi. Uwu ndiye mlingo wocheperako wodzadza mu cholembera.
• Pambuyo pakuika pansi pa khungu, singano iyenera kukhalapobe kwa masekondi 6. Pokhapokha ngati mwalowa mankhwalawo.
• Pambuyo pa jekeseni aliyense, singano amachotsedwa mu syringe. Izi zimalepheretsa kutulutsa kosalamulirika kwamadzi, zomwe zimapangitsa kuti pakhale kusintha kwa zotsalazo.

Protafan: malangizo ogwiritsira ntchito, mtengo, ndemanga ndi fanizo

Pali mankhwala ambiri pamsika wamankhwala omwe amapangidwa ndi makampani otchuka azamankhwala, koma kupeza yoyenera kwa wodwala aliyense wodwala matenda a shuga ndikovuta. Malinga ndi malangizo ogwiritsira ntchito, "Protafan NM" ili ndi katundu wabwino kwambiri ndipo ndi wokwera mtengo. Ganizirani mankhwalawa mwatsatanetsatane.

Kutulutsa mawonekedwe, kapangidwe kake ndi ma CD

Mankhwala ndikuyimitsidwa koyera. Ikasungidwa, imasanduka madzi opanda utoto wokhala ndi mpweya woyera. Izi sizitanthauza kuti mankhwalawa afooka - ndi kugwedezeka, kuyimitsidwa kumabweza mkhalidwe wake wakale.

• insulin-isophan pa ndende ya 100 IU pa 1 ml,
• nthaka ya chloride
• glycerin (glycerol),
• metacresol
• phenol
• sodium hydrogen phosphate dihydrate,
• protamine sulfate,
• sodium hydroxide ndi / kapena hydrochloric acid,
• madzi a jakisoni.

Imapezeka mu cartridge mtundu (5 zidutswa pa paketi iliyonse) kapena mu 10 ml mbale.

Opanga INN

Dzinalo losagwirizana ndi mayiko ena onse ndi insulin-isophan (umisiri wa chibadwa cha anthu).

Yopangidwa ndi Novo Nordisk, Bugswerd, Denmark. Pali ofesi yoimilira ku Russia.

Imasiyanasiyana kuchokera ku ma ruble 400 (pa botolo la 10 ml) mpaka ma ruble 900 (ma cartridge). Mankhwala ogulitsa pa intaneti amatha kupezeka pamtengo wotsika.

• lembani 1 ndi matenda ashuga 2
• lembani matenda ashuga 2 mwa amayi apakati.

Malangizo ogwiritsira ntchito (mlingo)

Zimatsimikiziridwa payekha kutengera kufunikira kwa thupi kwa insulin. Amasankhidwa ndi adotolo malinga ndi zotsatira za kusanthula. Mlingo wamba umachokera ku 0,5 mpaka 1 IU / kg patsiku.

Amagwiritsidwa ntchito pokhazikitsa ma subcutaneous. Itha kugwiritsidwa ntchito ngati monotherapy, komanso kuphatikiza ndi mankhwala ena. Nthawi zambiri, jakisoni amapangidwa ntchafu, phewa, matako kapena m'mimba. Ndikofunikira kusinthana mawebusayiti a jekeseni kuti muchepetse kukula kwa lipodystrophy. Chifukwa chake, pakatha mwezi umodzi, simungathe kubaya mankhwalawa kawiri m'malo amodzi.

Mimba komanso kuyamwa

Itha kugwiritsidwa ntchito munthawi yonse ya bere komanso nthawi yotsitsa, chifukwa sizikuwopseza kukula kwa mwana wosabadwayo ndipo samadutsa mkaka wa m'mawere.

Amayi amafunikira kusintha kosinthasintha kwa nthawi yayitali, chifukwa nthawi yayitali ya pakati, kufunika kwa insulin kumatha kusintha. Chifukwa chake, nthawi zambiri amachepetsa mu trimester yoyamba ndikuwonjezeka pambuyo pake.

Chifukwa chake, nthawi zonse muziwunika za momwe matenda anu aliri komanso kupewa hypoglycemia yomwe imavulaza kwambiri mwana.

Migwirizano ndi magwiritsidwe akusungidwa

Moyo wa alumali - zaka 2,5, litatha tsiku lotha ntchito.

Amasungidwa pamalo owuma, amdima, mufiriji pamtunda wa 2 mpaka 8 ° C. Osamawuma! Mukatsegula phukusi, moyo wa alumali ndi masabata 6 pa kutentha osaposa 30 digiri.

Ayenera kutetezedwa kwa ana.

Fananizani ndi fanizo

Pali mitundu ingapo yofanana ndi mankhwalawa.

Dzina, chinthu chogwira ntchito	Wopanga	Ubwino ndi kuipa	Mtengo, pakani.
Humulin, isophane insulin.	"Eli Lilly", USA, "BIOTON S.A.", Poland.	Ubwino: umatha kugwiritsidwa ntchito pa nthawi yoyembekezera komanso mwa ana ochepera zaka 18.

Mtengo ndi wokwera, gwiritsani ntchito mosamala mwa anthu azaka zopitilira 65.

kuchokera 500 (pa botolo la 10 ml), kuyambira 1100 (ma cartridge). "Biosulin", insulin-isophan.Pharmstandard-Ufavita, Russia.Ubwino: sizotsatira zoyipa zambiri.

Kuyang'anira madokotala ndikofunikira mukamagwiritsa ntchito odwala okalamba, zimafunanso nthawi yayitali kuyembekezera kuyamba.

kuchokera 500 (botolo la 10 ml), kuchokera 900 (makatoni a ma syringe pensulo). Levemir, insulin detemir.Novo Nordisk, Denmark.Ubwino: Zimatenga nthawi yayitali, mulibe protamine, zomwe zingayambitse ziwengo.

Mtengo: wokwera mtengo kwambiri, osavomerezeka kwa ana osakwana zaka 6.

kuyambira 1800 (syringe pensulo).

Kusintha chithandizo chamankhwala chimodzi ndi chotheka ndi dokotala wokha. Kudzipatsa nokha koletsedwa!

Insulin Protafan: malangizo osintha komanso kuchuluka kwake

Chithandizo chamakono cha matenda ashuga chimaphatikizapo kugwiritsa ntchito mitundu iwiri ya insulin: kuphimba zofunikira zazikulu komanso kulipiritsa shuga mutatha kudya. Mwa mankhwala a sing'anga kapena apakatikati, mzere woyamba pamtunduwu umakhala ndi Protafan insulin, kugulitsa kwake pamsika kuli pafupifupi 30%.

Wopanga, kampani Novo Nordisk, ndiwotchuka padziko lonse polimbana ndi matenda a shuga. Chifukwa cha kafukufuku wawo, insulini idawoneka chakumapeto kwa 1950 ndikuchita kwanthawi yayitali, zomwe zidapangitsa kuti moyo wawo ukhale wosavuta. Protafan ili ndi kuyeretsa kokwanira, kokhazikika komanso zodziwikiratu.

Malangizo achidule

Protafan imapangidwa mosiyanasiyana. DNA yofunikira pakuphatikizidwa kwa insulin imayambitsidwa mu tizilombo toyambitsa matenda, pambuyo pake amayamba kupanga proinsulin. Insulin yomwe imapezeka pambuyo pa chithandizo cha enzymatic imafanana kwathunthu ndi munthu.

Kuti ichulukitse kuchitapo chake, timadzi timene timasakanikirana ndi protamine, ndipo timabisala pogwiritsa ntchito ukadaulo wapadera. Mankhwala opangidwa mwanjira iyi amadziwika ndi kupangika kosalekeza, mutha kutsimikiza kuti kusintha kwa botolo sikukhudza shuga.

Kwa odwala, izi ndizofunikira: zinthu zochepa zomwe zimakhudza kugwira ntchito kwa insulin, kubwezeredwa kwabwino kwa matenda ashuga kudzakhala.

Protafan HM imapezeka m'mbale zamagalasi ndi 10 ml ya yankho. Mwanjira imeneyi, mankhwalawa amalandiridwa ndi azachipatala komanso odwala matenda ashuga omwe amaba jakisoni ndi syringe. Mu katoni 1 ndi botolo ndi malangizo ogwiritsira ntchito.

Protafan NM Penfill ndi ma cartridge atatu a 3 ml omwe amatha kuyikidwa mu zolembera za NovoPen 4 syringe (gawo 1) kapena NovoPen Echo (magawo 0,5). Kuti mukhale ndi mwayi wosakanikirana mu cartridge iliyonse galasi. Phukusili limakhala ndi ma cartridge 5 ndi malangizo.

Kuchepetsa shuga m'magazi ndikuwanyamula kupita nawo ku minofu, kukulitsa kapangidwe ka glycogen mu minofu ndi chiwindi. Zimapangitsa mapangidwe a mapuloteni ndi mafuta, chifukwa chake, zimathandizira kulemera.

Amagwiritsidwa ntchito popanga shuga osala kudya: usiku komanso pakati pa chakudya. Protafan sangagwiritsidwe ntchito kukonza glycemia, ma insulin amafupikitsa amapangidwira izi.

Kufunika kwa insulini kumawonjezeka ndi kupsinjika kwa minofu, kuvulala kwamthupi ndi m'maganizo, kutupa, ndi matenda opatsirana. Kugwiritsa ntchito mowa mu shuga sikwabwino, chifukwa kumathandizira kuwonongeka kwa matendawa ndipo kumayambitsa hypoglycemia.

Kusintha kwa Mlingo kumafunika mukamamwa mankhwala ena. Kuchulukitsa - kugwiritsa ntchito okodzetsa ndi mankhwala ena a mahomoni. Kuchepetsa - pankhani ya makonzedwe amodzimodzi munthawi yomweyo mapiritsi ochepetsa shuga, tetracycline, aspirin, antihypertensive mankhwala ochokera m'magulu a AT1 receptor blockers ndi ACE inhibitors.

Zotsatira zoyipa kwambiri za insulin iliyonse ndi hypoglycemia. Mukamagwiritsa ntchito mankhwala a NPH, chiopsezo chobwera ndi shuga usiku ndichokwera, popeza ali ndi chiwopsezo chochita.

Nocturnal hypoglycemia ndiowopsa kwambiri mu matenda osokoneza bongo, chifukwa wodwalayo sangathe kuzindikira okha ndikuwathetsa okha.

Mchere wotsika usiku chifukwa cha mlingo wosankhidwa mosayenera kapena chinthu chama metabolic.

Osachepera 1% ya anthu odwala matenda ashuga, Protafan insulin imayambitsa matenda osakhwima a m'thupi mwa zotupa, kuyabwa, kutupa m'malo a jakisoni. Kuthekera kwa mitundu yayikulu yolumikizana ndi kochepera 0.01%. Kusintha kwamafuta obisika, lipodystrophy, amathanso kuchitika. Chiwopsezo chawo chimakhala chachikulu ngati njira ya jakisoni satsatiridwa.

Protafan amaletsedwa kugwiritsa ntchito mwa odwala omwe ali ndi matendawa kapena edincke's edema ya insulin. Monga cholowa m'malo, ndibwino kuti musagwiritse ntchito ma NPH omwe ali ndi mawonekedwe ofanana, koma insulin analogues - Lantus kapena Levemir.

Protafan sayenera kugwiritsidwa ntchito ndi anthu odwala matenda ashuga okhala ndi vuto la hypoglycemia, kapena ngati zizindikiro zake zachotsedwa. Zinapezeka kuti ma insulin analogu pamilandu imeneyi ndi otetezeka kwambiri.

Kufotokozera	Protafan, monga ma insulin onse a NPH, amawatulutsa mosapumira. Pansi pali yoyera yoyera, pamwambapa - madzi opatsirana. Pambuyo posakaniza, yankho lonse limakhala loyera. Ndende ya yogwira ntchito ndi magawo zana pa millilita.
Kutulutsa Mafomu
Kupanga	Chosakaniza chophatikizacho ndi insulin-isophan, wothandizira: madzi, protamine sulfate kuti ikhale nthawi yayitali yochita, phenol, metacresol ndi zinc ion ngati zosungika, zinthu zosintha acidity yankho.
Machitidwe
Zizindikiro	Matenda a shuga ndi odwala omwe amafuna insulin, ngakhale atakhala zaka zingati. Ndi matenda amtundu wa 1 - kuyambira kumayambiriro kwa zovuta za carbohydrate, ndi mtundu wachiwiri - pamene mapiritsi ochepetsa shuga ndi osagwira mokwanira, ndipo hemoglobin ya glycated imaposa 9%. Matenda a shuga kwa amayi apakati.
Kusankha kwa Mlingo	Malangizowo alibe mulingo woyenera, chifukwa kuchuluka kwa insulin kwa odwala matenda ashuga osiyanasiyana ndi kosiyana kwambiri. Amawerengeredwa pamaziko a kusala kudya kwa glycemia. Mlingo wa insulin m'mawa ndi madzulo makonzedwe amasankhidwa mosiyanasiyana - kuwerengetsa kwa insulin ya mitundu yonse iwiri.
Kusintha kwa Mlingo
Zotsatira zoyipa
Contraindication
Kusunga	Pamafunika kutetezedwa ndi kuwala, kuzizira kozizira komanso kutentha kwambiri (> 30 ° C). Mbale ziyenera kusungidwa m'bokosi, insulini mu syringe pens iyenera kutetezedwa ndi chipewa. Mu nyengo yotentha, zida zapadera zozizira zimagwiritsidwa ntchito kunyamula Protafan. Mikhalidwe yoyenera kwambiri yosungirako kwa nthawi yayitali (mpaka masabata 30) ndi mashelufu kapena chitseko cha firiji. Potentha firiji, Protafan poyambira amatha sabata 6.

Nthawi yogwira

Mlingo wa kulowa kwa Protafan kuchokera kuzinthu zowerengeka kulowa m'magazi mwa odwala omwe ali ndi matenda ashuga ndizosiyana, kotero ndizosatheka kuneneratu molondola nthawi yomwe insulin iyamba kugwira ntchito. Zambiri:

1. Kuchokera pa jakisoni mpaka pakuwoneka kwa timadzi m'magazi, pafupifupi maola 1.5 amapita.
2. Protafan ili ndi chochita chapamwamba, mu odwala matenda ashuga ambiri amapezeka maola 4 kuyambira nthawi yoyendetsa.
3. Kutalika konse kwa kuchitako kumafika maola 24. Pankhaniyi, kudalira kwa nthawi yayitali yogwira ntchito pamtengowu. Ndi kukhazikitsidwa kwa magawo 10 a Protafan insulin, kutsitsa kwa shuga kumawonedwa pafupifupi maola 14, magawo 20 kwa maola pafupifupi 18.

Malangizo a jekeseni

Nthawi zambiri wodwala matenda ashuga, kuyendetsa kawiri ka Protafan ndikokwanira: m'mawa komanso asanagone. Jakisoni wamadzulo azikhala okwanira kusunga glycemia usiku wonse.

Moni Dzina langa ndine Alla Viktorovna ndipo ndilibenso matenda ashuga! Zinanditengera masiku 30 okha ndi ma ruble 147.kubwezeretsa shuga kwazonse komanso osadalira mankhwala osathandiza omwe ali ndi zotsatirapo zoyipa.

>>Mutha kuwerenga nkhani yanga mwatsatanetsatane apa.

Momwe mulingo woyenera:

• shuga m'mawa ndizofanana ndi nthawi yogona
• palibe hypoglycemia usiku.

Nthawi zambiri, shuga m'magazi amakwera pambuyo pa 3 am, pamene kupanga kwa mahomoni otsutsana kumagwira kwambiri, ndipo zotsatira za insulin zimafooka.

Ngati chiwonetsero cha Protafan chikutha m'mbuyomu, chiwopsezo chaumoyo ndi chotheka: hypoglycemia usiku ndi shuga m'mawa kwambiri. Kuti mupewe, muyenera kuyang'ana kuchuluka kwa shuga pa 12 ndi maola atatu.

Nthawi ya jakisoni wamadzulo ikhoza kusinthidwa, kusintha mawonekedwe a mankhwalawo.

Zomwe zikuchitika pazing'ono

Ndi matenda a shuga a 2, matenda ashuga azimayi oyembekezera, ana, achikulire pa chakudya chamafuta ochepa, kufunika kwa NPH insulin kungakhale kochepa. Ndi mtundu umodzi wocheperako (mpaka maunitsi 7), nthawi yogwira Protafan ikhoza kuchepera maola 8. Izi zikutanthauza kuti jakisoni awiri omwe aperekedwa ndi malangizo sangakhale okwanira, ndipo pakati pa shuga magazi azikula.

Izi zitha kupewedwa pobaya jakisoni wa Protafan insulin katatu pakatha maola 8 aliwonse: jakisoni woyamba amaperekedwa akangodzuka, wachiwiri nthawi ya nkhomaliro ndi insulin yochepa, yachitatu, yayikulu kwambiri, asanagone.

Ndemanga za odwala matenda ashuga, sikuti aliyense amakwanitsa kubwezera zabwino za anthu odwala matenda ashuga motere. Nthawi zina mlingo wa usiku umaleka kugwira ntchito musanadzuke, ndipo shuga m'mawa amakhala okwera. Kuonjezera mlingo kumabweretsa bongo wa insulin ndi hypoglycemia. Njira yokhayo yochotsera izi ndikusinthira ma insulin omwe ali ndi nthawi yayitali.

Zakudya zotere

Anthu odwala matenda ashuga omwe amapezeka pa insulin amakhalapo nthawi zambiri amakhala ndi insulin.Mwachidule ndikofunikira kuti muchepetse shuga omwe amalowa m'magazi kuchokera ku chakudya. Amagwiritsidwanso ntchito kukonza glycemia. Pamodzi ndi Protafan ndibwino kugwiritsa ntchito kukonzekera kwapafupi kwa wopanga yemweyo - Actrapid, yemwe amapezekanso mumbale ndi ma cartridgeges a syringe pens.

Nthawi yoyendetsera insulin Protafan sikudalira zakudya mwanjira iliyonse, kuphatikiza pakati pa jakisoni ndikokwanira. Mukasankha nthawi yabwino, muyenera kutsatira nthawi zonse.

Ngati chikugwirizana ndi chakudya, Protafan ikhoza kudulidwa ndi insulin yochepa.

Nthawi yomweyo kuzisakaniza mu syringe yomweyo ndikosayenera, popeza ndizotheka kulakwitsa ndi mlingo ndikuchepetsera kuchitapo kanthu kwa timadzi tating'onoting'ono.

Mulingo woyenera

Mu shuga mellitus, muyenera jakisoni insulin momwe angathere kuti matenda abwinobwino azikhala ndi shuga. Malangizo ogwiritsira ntchito sanakhazikitse mlingo wapamwamba. Ngati mulingo woyenera wa Protafan insulin ukukula, izi zitha kuwonetsa kukana insulini. Ndi vutoli, muyenera kufunsa dokotala. Ngati ndi kotheka, adzalembera mapiritsi omwe amathandiza kusintha kwa mahomoni.

Kugwiritsa Ntchito Mimba

Ngati ndi gestational matenda a shuga sizingatheke kukwaniritsa glycemia kokha kudzera mu chakudya, odwala amathandizidwa ndi insulin. Mankhwala ndi mlingo wake amasankhidwa mosamala, popeza onse a hypo- ndi hyperglycemia amawonjezera chiopsezo cha kusokonezeka kwa mwana. Insulin Protafan imaloledwa kugwiritsidwa ntchito panthawi yomwe ali ndi pakati, koma nthawi zambiri, analogi yayitali imakhala yothandiza kwambiri.

Kodi mumazunzidwa ndi kuthamanga kwa magazi? Kodi mukudziwa kuti matenda oopsa amathanso kukopeka ndi mtima ndi kumenyedwa? Sinthani nkhawa zanu ndi ... Maganizo ndi mayankho okhudza njira zomwe mwawerenga apa >>

Mimba ikapezeka ndi matenda amtundu woyamba 1, ndipo mayiyo amakwaniritsa bwino matenda a Protafan, kusintha kwa mankhwala sikofunikira.

Kuyamwitsa kumayenda bwino ndi insulin. Protafan sichingavulaze thanzi la mwana. Insulin imalowa mkaka wambiri, pambuyo pake imasweka m'matumbo a mwana, ngati protein ina iliyonse.

Protafan analogu, kusinthana ndi insulin ina

Zofanizira kwathunthu kwa Protafan NM zomwe zimagwira ntchito zomwezi komanso nthawi yayifupi yogwira ntchito ndi:

• Humulin NPH, USA - mpikisano wamkulu, ali ndi gawo la msika loposa 27%,
• Insuman Bazal, France,
• Biosulin N, RF,
• Rinsulin NPH, RF.

Kuchokera pakuwona kwa mankhwala, kusintha kwa Protafan kupita ku mankhwala ena a NPH sikusintha kwa insulin ina, ndipo ngakhale maphikidwe ndi chinthu chokhacho chomwe chikuwonetsedwa, osati mtundu winawake.

Mwakuchita izi, kulowetsedwa koteroko sikungangowononga chiwopsezo cha glycemic kwakanthawi ndipo kumafunikira kusintha kwa mlingo, komanso kumayambitsa ziwengo.

Ngati glycated hemoglobin ndi yachilendo komanso hypoglycemia sichachilendo, sibwino kukana insulin Protafan.

Kusiyana kwa insulin analogues

Ma aligine amtundu wa insulin wambiri, monga Lantus ndi Tujeo, omwe alibe nsapato, amatha kuloledwa bwino ndipo samayambitsa matenda. Ngati munthu wodwala matenda ashuga atasiya kusowa chifukwa cha zifukwa zina, Protafan iyenera kusinthidwa ndi ma insulin amakono.

Zowonongeka zawo zazikulu ndizokwera mtengo kwawo. Mtengo wa Protafan ndi pafupifupi ruble 400. kwa botolo ndi 950 yonyamula ma cartridge a ma syringe pens. Ma insulin analogu ali pafupifupi 3 times okwera mtengo.

Onetsetsani kuti mwaphunzira! Kodi mukuganiza kuti mapiritsi ndi insulin ndi njira yokhayo yoyeserera shuga kuwongolera? Sichowona! Mutha kutsimikizira izi nokha ndikuyamba kugwiritsa ntchito ... werengani zambiri >>