Gliclazide MV > Chithandizo ndi kupewa

Gliclazide MV: malangizo ogwiritsa ntchito ndi kuwunikira

Dzina lachi Latin: Gliclazide MV

Code ya ATX: A10BB09

Zogwira pophika: gliclazide (gliclazide)

Wopanga: LLC Ozon, LLC Atoll (Russia)

Sinthani mafotokozedwe ndi chithunzi: 01/14/2018

Mitengo muma pharmacies: kuchokera ku ma ruble 81.

Gliclazide MV ndi mankhwala osokoneza bongo a hypoglycemic.

Kutulutsa mawonekedwe ndi kapangidwe kake

Gliclazide MV imapangidwa ngati mapiritsi okhala ndi mtundu wosinthika: cylindrical, biconvex, yoyera yokhala ndi kirimu wowiritsa kapena yoyera, kuyenda pang'ono pang'ono (10, 20 kapena 30 zidutswa mu contour aluminium kapena polyvinyl chloride cell phukusi, 1, 2, 3, 4, 5, 6, 10 mapaketi okhala ndi mtolo wa makatoni, 10, 20, 30, 40, 50, 60, kapena ma PC.Matumba apulasitiki, 1 amatha mu mtolo wa makatoni).

Piritsi limodzi lili ndi:

The yogwira mankhwala: gliclazide - 30 mg,
Zothandiza: hypromellose - 70 mg, colloidal silicon dioxide - 1 mg, cellcrystalline cellulose - 98 mg, magnesium stearate - 1 mg.

Mankhwala

Glyclazide ndi sulfonylurea yotengedwa yomwe imakhala ndi hypoglycemic katundu ndipo imapangidwira pakamwa. Kusiyana kwake ndi mankhwala omwe ali mgululi ndi kukhalapo kwa mphete ya heterocyclic ya N yokhala ndi chomangira cha endocyclic.

Gliclazide amachepetsa shuga wamagazi, pokhala othandizira pakupanga insulin ndi maselo a beta a isanger a Langerhans. Kuchuluka kwa C-peptide ndi insulin ya postprandial imapitirira pambuyo pa zaka 2 za chithandizo. Monga momwe zimakhalira ndi zinthu zina za sulfonylurea, izi zimachitika chifukwa cha zomwe β-cell za zisumbu za Langerhans zimayambitsa kukoka kwa glucose, zomwe zimachitika molingana ndi mtundu wa thupi. Gliclazide samangoyendetsa kagayidwe kazakudya, komanso zimakhumudwitsa zotsatira za hemovascular.

Odwala omwe ali ndi mtundu wachiwiri wa matenda a shuga, gliclazide imathandizira kubwezeretsa kupanga kwa insulin koyambirira, zomwe zimachitika chifukwa cha kuchuluka kwa shuga komanso zimapangitsa gawo lachiwiri la insulin kutulutsa. Kuwonjezeka kwakukulu kwa kaphatikizidwe ka insulin kumayenderana ndi kuyankha komwe kumayambitsidwa ndi shuga kapena kudya.

Kugwiritsidwa ntchito kwa gliclazide kumachepetsa chiopsezo chokhala ndi chotupa cham'magazi a m'magazi mwakuchita zinthu zomwe zingapangitse kukula kwa zovuta kwa odwala omwe ali ndi matenda osokoneza bongo, kuchepa kwa zomwe zili m'maselo a cell plation (thromboxane B₂, beta-thromboglobulin), kupewera pang'ono kwa kupatsidwa zinthu za m'magazi komanso kuphatikiza, komanso kukhudza kubwezeretsanso kwa ntchito ya fibrinolytic ya vascular endothelium, ndikuwonjezera ntchito ya plasminogen, yomwe imathandizira minofu.

Kugwiritsa ntchito glycazide yosinthidwa, glycosylated hemoglobin (HbAlc) yomwe ikutsikira ndi yochepera 6.5%, chifukwa cholamulira kwambiri glycemic molingana ndi mayeso odalirika azachipatala, ingachepetse chiopsezo cha zovuta zazikuluzikulu za mtundu waukulu wa 2 poyerekeza ndi glycemic yachikhalidwe ulamuliro.

Kukhazikitsa kwa glycemic kwambiri kumakhala ndi mankhwala a gliclazide (pafupifupi tsiku ndi tsiku ndi 103 mg) ndikuwonjezera mlingo wake (mpaka 120 mg patsiku) mukamalandira mankhwala ena kumbuyo (kapena m'malo mwake) musanawonjezere ndi mankhwala ena a hypoglycemic (mwachitsanzo, insulin, metformin thiazolidinedione derivative, alpha glucosidase inhibitor). Kugwiritsa ntchito gliclazide pagulu la odwala omwe akuwongolera kwambiri glycemic (pafupifupi, mtengo wa HbAlc anali 6.5% ndipo nthawi yayitali yowunikira inali zaka 4.8), poyerekeza ndi gulu la odwala omwe akuyang'aniridwa muyezo (kuchuluka kwa HbAlc kunali 7.3% ,, adatsimikiza kuti chiwopsezo chopezeka pafupipafupi cha macro- cell ndi macrovascular chimachepetsedwa kwambiri (10%) chifukwa cha kuchepa kwakukulu pangozi yolimbana ndi zovuta zazikulu za microvascular (pofika 14%), nthawi Itijah ndi Kukula kwa microalbuminuria (9%), zosokonezeka aimpso (11%), isanayambike ndi Kukula kwa nephropathy (21%), ndi chitukuko cha macroalbuminuria (30%).

Mukamapereka mankhwala a gliclazide, kuwongolera kwambiri glycemic kumakhala ndi maubwino ambiri osakhazikitsidwa ndi zotsatira za mankhwala omwe ali ndi antihypertensive mankhwala.

Pharmacokinetics

Pambuyo pakukonzekera pakamwa, glycoside imalowa mu gawo logaya chakudya ndi 100%. Zomwe zili m'madzi a m'magazi zimachulukana pang'onopang'ono m'maola 6, ndipo ndendeyo imakhala yokhazikika kwa maola 6-12. Kuchuluka kwa mayamwidwe a gliclazide palokha popanda chakudya.

Pafupifupi 95% yazinthu zonse zomwe zimagwira ntchito zimagwirira kumapuloteni a plasma. Kuchuluka kwa magawo ndi pafupifupi malita 30. Kulandila kwa Gliclazide MV mu mulingo wa 60 mg kamodzi patsiku kumakupatsani kukhalabe achire ambiri a gliclazide mu madzi am'magazi kwa maola 24 kapena kupitilira.

Gliclazide metabolism imachitika makamaka m'chiwindi. Ma metabolacologic omwe amagwira ntchito mu plasma sanatsimikizike. Gliclazide imatheka makamaka kudzera mu impso mu mawonekedwe a metabolites, pafupifupi 1% imachotsedwa mu mkodzo. Hafu yapakati ya moyo ndi maola 16 (chizindikirocho chimatha kusiyanasiyana pakati pa maola 12 mpaka 20).

Chiyanjano chotsogola chinajambulidwa pakati pa mankhwala ovomerezeka (osapitirira 120 mg) ndi malo omwe ali pansi pa pharmacokinetic curve "nthawi -". Odwala okalamba, palibe kusintha kwakukuru kwamapiritsi a pharmacokinetic.

Zizindikiro zogwiritsidwa ntchito

Malinga ndi malangizowo, Gliclazide MV imalembedwa kuti ichiritse matenda osokoneza bongo a mtundu 2 matenda a shuga (osagwirizana ndi insulin) poyambira matenda ashuga a shuga.

Mankhwalawa amagwiritsidwanso ntchito kupewa zinthu zazing'ono zam'mimba (munthawi yomweyo ndi zina zotumphukira za sulfonylurea).

Contraindication

Mtundu woyamba wa matenda a shuga 1
Matenda akulu a chiwindi ndi impso,
Ketoacidosis
Matenda a shuga ndiodwala
Ntchito zogwirizana ndi imidazole zotumphukira (kuphatikizapo miconazole),
Hypersensitivity kuti sulfonamides ndi sulfonylureas.

Kugwiritsidwa ntchito kwa Glyclazide MV sikulimbikitsidwa kuti azimayi anyama ndi apakati.

Malangizo ogwiritsira ntchito Gliclazide MV: njira ndi mlingo

Gliclazide MV imatengedwa pakamwa asanadye.

Kuchulukana kwa mankhwalawa ndi 2 kawiri pa tsiku.

Dokotala amadziwitsa tsiku lililonse mlingo uliwonse, kutengera mawonekedwe ake a matendawa ndi glycemia, pamimba yopanda kanthu komanso maola awiri atatha kudya.

Monga lamulo, mlingo woyambirira ndi 80 mg patsiku, avareji yapakati ndi 160-320 mg patsiku.

Zotsatira zoyipa

Pogwiritsa ntchito Gliclazide MV, ndizotheka kukulitsa zovuta m'magulu ena a thupi:

Matumbo ochita kuperewera: kawirikawiri - nseru, matenda a m'mimba, kutsegula m'mimba, kusanza, kupweteka kwa epigastric,
Endocrine dongosolo: mankhwala osokoneza bongo - hypoglycemia,
Hematopoietic dongosolo: nthawi zina - thrombocytopenia, leukopenia kapena agranulocytosis, magazi m'thupi (nthawi zambiri amasintha),
Thupi lawo siligwirizana: kuyabwa, zotupa pakhungu.

Bongo

Mankhwala osokoneza bongo a MV Glyclazide angayambitse kukula kwa hypoglycemia, ndipo m'malo ovuta kwambiri, hypoglycemic coma.

Zizindikiro zolimbitsa thupi za hypoglycemia zimakonzedwa ndikusintha kwa zakudya, kusankha kwa mankhwalawa komanso / kapena kudya zakudya zamagulu ambiri. Kuyang'anira wodwalayo mosamala kuyenera kupitilizidwa mpaka kuopseza moyo ndi thanzi. Matenda akuluakulu obwera chifukwa cha hypoglycemic angayambenso, limodzi ndi kukomoka, chikomokere, kapena mavuto ena amkati wamanjenje. Ngati zoterezi zikuchitika, ndikulimbikitsidwa kuti chisamaliro chamankhwala chodzidzimutsa chisatengedwe ndikufunika kuchipatala.

Wodwala akapezeka kuti ali ndi vuto la hypoglycemic com kapena akuganiza kuti ali nalo, ayenera kupatsidwa (kudzera m'mitsempha, jet) 50 ml ya yankho la 40% ya shuga (dextrose). Pambuyo pake, 5% dextrose solution imalowetsedwa kudzera m'mitsempha, yomwe imakuthandizani kuti muzikhala ndi glucose yoyenera m'magazi (pafupifupi 1 g / l). Magazi a glucose amayenera kuyang'aniridwa mosamala ndipo wodwalayo ayenera kuyang'aniridwa mosalekeza kwa masiku osachepera awiri atapezeka kuti ali ndi vuto losokoneza bongo. Kufunika kowunikira ntchito zofunika kwambiri za wodwala kumatsimikizidwanso ndi momwe alili.

Popeza gliclazide imamangilira kwakukulu mapuloteni a plasma, dialysis siyothandiza.

Malangizo apadera

Pochiza matenda osokoneza bongo omwe amadalira shuga, Gliclazide MV iyenera kugwiritsidwa ntchito nthawi yomweyo ndi zakudya zama calorie zochepa zomwe zimakhala ndi chakudya.

Pa mankhwala, muyenera kuyang'anira kusinthasintha kwa tsiku ndi tsiku m'magazi a glucose, komanso kuchuluka kwa shuga m'magazi pamimba yopanda kanthu ndikatha kudya.

Ndi chithandizo cha opaleshoni kapena kuwonongeka kwa matenda a shuga, kutha kugwiritsa ntchito mankhwala a insulin kuyenera kuganiziridwanso.

Pankhani ya hypoglycemia, ngati wodwalayo akudziwa, shuga (kapena shuga) ayenera kugwiritsidwa ntchito pakamwa. Zikatayika, glucose (intravenously) kapena glucagon (subcutaneously, intramuscularly kapena intravenally) amayenera kuperekedwa. Pofuna kupewa kukonzanso kwa hypoglycemia pambuyo pobwezeretsa chikumbumtima, wodwalayo ayenera kupatsidwa chakudya chopatsa thanzi.

Kugwiritsa ntchito nthawi yomweyo gliclazide ndi cimetidine osavomerezeka.

Ndi kuphatikiza kwa gliclazide ndi verapamil, ndikofunikira kuyang'anitsitsa kuchuluka kwa shuga m'magazi, ndi acarbose, kuyang'anira mosamala ndi kuwongolera kwa kuchuluka kwa mankhwalawa a hypoglycemic othandizira ndikofunikira.

Kukopa pa kuthekera koyendetsa magalimoto ndi njira zowerengeka

Odwala omwe akutenga Gliclazide MV ayenera kudziwa zovuta za hypoglycemia ndikuwachenjeza za kufunika kosamala mukamayendetsa kapena kuchita ntchito zina zomwe zimafuna kuti ma psychomotor ayambe kusintha, makamaka kumayambiriro kwa chithandizo.

Zotsatira za mankhwala

Gliclazide MV ndi othandizira pakamwa chomwe ndi chochokera m'badwo wachiwiri wa sulfonylurea. Kukonzekera kwa gululi kwakhala kukugwiritsidwa ntchito kuyambira kalekale pazachipatala, kuyambira m'ma 1950s. Nkhondo yachiwiri yapadziko lonse, mankhwalawa adagwiritsidwa ntchito kuthana ndi matenda osiyanasiyana, ndipo mwangozi pomwe zotsatira zawo za hypoglycemic zidapezeka.

Dziko lopanga mankhwalawa ndi Russia. Glyclazide MV 30 mg m'mapiritsi ndi mtundu wokhawo wa mankhwala omwe kampani yopanga mankhwala amapanga. MB yodziyimira imayimira Kutulutsidwa Kosinthidwa. Izi zikutanthauza kuti mapiritsi a MV amalowetsedwa m'mimba kwa maola atatu, kenako kulowa m'magazi ndikuchepetsa kuchuluka kwa shuga m'magazi. Mankhwalawa amathandizira kuchepetsa kuchepa kwa shuga, motero, amayamba kukhala ndi vuto la hypoglycemia nthawi zambiri (1% yokha ya milandu).

Mankhwala Gliclazide MV munthawi yogwiritsa ntchito ali ndi zotsatira zabwino mthupi la wodwalayo:

Zimakwiyitsa kupanga kwa insulin ndi kapamba.
Amachepetsa shuga.
Imakhala ndi insulin mobisa yokhala ndi shuga.
Kuchulukitsa minofu kukhudzana ndi timadzi.
Imakhazikika pamlingo wa glycemia pamimba yopanda kanthu.
Imachepetsa kupanga shuga.
Zimakhudza kagayidwe kazachilengedwe komanso kagayidwe kazakudya.

Kuphatikiza apo, mankhwalawa amachepetsa mwayi wamagazi m'mitsempha.

Malangizo ogwiritsira ntchito mankhwalawa

Pankhaniyi, mankhwala omwe amadzipangira nokha sangathe kuchitidwa, kungokhala dokotala, atatha kudziwa kufunika kwa mankhwalawo komanso kuvulaza kwake m'thupi la wodwalayo, atha kutumiza mapiritsi a Glyclazide MV.

Pambuyo pofunsa dokotala, muyenera kugula mankhwala omwe mumalandira, omwe ali ndi mapiritsi 60. Mankhwala amagwiritsidwa ntchito ngati:

Mankhwala a shuga osadalira insulin, pamene zakudya zoyenera komanso kuchita masewera olimbitsa thupi sizingathe kuthana ndi kuchepa kwa ndende yamagazi.
Pofuna kupewa zotsatira za matenda - nephropathy (matenda a impso) ndi retinopathy (kutupa kwa ma eyebones).

Malangizo ogwiritsira ntchito ali ndi chidziwitso chonse chokhudza mapiritsi, omwe muyenera kuwerenga mosamala. Mlingo woyambirira wa odwala omwe akungoyamba chithandizo, ndipo kwa anthu azaka zopitilira 65 ndi 30 mg patsiku. Amadyedwa nthawi ya chakudya cham'mawa. Pambuyo pa milungu iwiri ya chithandizo, adokotala amasankha kuwonjezera kuchuluka kwake. Pali zinthu ziwiri zomwe zimapangitsa izi - kuchuluka kwa shuga komanso kuopsa kwa matenda ashuga. Mwambiri, mlingo umasiyana 60 mpaka 120 mg.

Wodwala akaphonya kumwa mankhwalawa, ndiye kuti mlingo wowirikiza sayenera kumwa mulimonse. Ngati pakufunika kusintha kudya kwa Gliclazide MV ndi mankhwala ena ochepetsa shuga, ndiye kuti mankhwalawo amasintha kuchokera tsiku lotsatira. Kuphatikizika uku ndikotheka ndi metformin, insulin, komanso alpha glucosidase inhibitors. Odwala omwe ali ndi vuto lochepa kwambiri laimpso amatenga mlingo womwewo. Odwala omwe ali pachiwopsezo cha hypoglycemia amagwiritsa ntchito mankhwalawa ndi Mlingo wotsika kwambiri.

Mapiritsi amayenera kutetezedwa m'malo osakwaniritsidwa ndi ana aang'ono, kutentha kwa mpweya osaposa 25C. Mankhwalawa ndi oyenera zaka zitatu.

Tsiku lotha ntchito litatha, kugwiritsa ntchito kwake nkoletsedwa.

Mtengo ndi fanizo la mankhwala

Popeza mankhwalawa amapangidwa ndi opanga zoweta, mtengo wake siwokwera kwambiri. Mankhwalawa atha kugulidwa ku malo ogulitsira mankhwala kapena kutsegula pa intaneti pa intaneti, mukamapereka mankhwala a dokotala. Mtengo wa mankhwala Gliclazide MV (30 mg, 60 zidutswa) umachokera ku 117 mpaka 150 ma ruble. Chifukwa chake, aliyense amene ali ndi ndalama zapafupifupi angakwanitse.

Ma synonyms a mankhwalawa ndi mankhwala omwe amakhalanso ndi gliclazide yogwira mankhwala. Izi zikuphatikizapo Glidiab MV, Diabeteson MV, Diabefarm MV. Tiyenera kudziwa kuti mapiritsi a Diabeteson MV (30 mg, 60 zidutswa) ndi okwera mtengo kwambiri: mtengo wapakati ndi ma ruble 300. Ndipo mphamvu ya mankhwalawa ndiyofanana.

Wodwalayo akakumana ndi zotsutsana ndi gliclazide ya mankhwala kapena mankhwalawo ndi owopsa, dokotala amayenera kusintha njira yochizira. Kuti achite izi, atha kukulemberani mankhwala omwewo, omwe amaperekanso matenda a hypoglycemic, mwachitsanzo:

Amaryl M kapena Glemaz wokhala ndi glimepiride yogwira,
Glurenorm yogwira glycidone,
Maninil ndi yogwira pophika glibenclamide.

Ili ndiye mndandanda wosakwanira wa ma analogu onse, zambiri zowonjezereka zitha kupezeka pa intaneti kapena funsani dokotala.

Wodwala aliyense amasankha njira yabwino kwambiri yochizira pazinthu ziwiri - mtengo ndi njira yothandizira.

Maganizo a odwala pankhani ya mankhwalawa

Masiku ano, mankhwalawa omwe ali m'gulu lachiwiri la sulfonylurea, kuphatikizapo mankhwala a Gliclazide MV, amagwiritsidwa ntchito kwambiri. Izi ndichifukwa choti mapiritsi ali ndi zotsatira zoyipa zambiri, zimachitika kangapo.

Kafukufuku wasayansi atsimikizira zotsatira zabwino za mankhwalawa pa microcirculation. Kuphatikiza apo, mankhwalawa amalepheretsa kukula kwamavuto ambiri:

microvascular pathologies - retinopathy ndi nephropathy,
matenda a shuga a shuga
kuchuluka kwa zakudya zamagulu onse,
kuchepa kwa mtima stasis.

Poyerekeza ndemanga za odwala ambiri, titha kuwunikira malingaliro ena ogwiritsira ntchito mankhwalawa:

Mapiritsi ndi bwino kudya mukatha kudya chakudya cham'mawa,
kadzutsa uyenera kukhala ndi chakudya chamafuta kwambiri,
sungakhale ndi njala tsiku lonse,
mukukumana ndi mavuto akuthupi, muyenera kusintha mlingo.

Komanso, ndemanga za anthu ena odwala matenda ashuga zikusonyeza kuti kutsatira kwambiri zakudya zamafuta ochepa komanso kuchita masewera olimbitsa thupi kwambiri kungayambitse matenda a hypoglycemia. Izi zikugwiranso ntchito kwa iwo omwe amamwa mowa ndikumwa mapiritsi. Chiwopsezo chakuchepa kwambiri kwa shuga m'magazi mulinso mwa anthu achikulire.

Anthu odwala matenda ashuga amasiya ndemanga zawo kuti mankhwalawa ndi osavuta kugwiritsa ntchito poyerekeza ndi gliclazide yachilendo, mlingo wake womwe umachulukanso kawiri. Mlingo umodzi patsiku umapereka pang'onopang'ono komanso mogwira mtima, kutsitsa glucose bwino. Komabe, panali milandu yomwe atagwiritsa ntchito mankhwalawa kwa nthawi yayitali (pafupifupi zaka 5), zotsatira zake sizinathandize, ndipo adotolo adapereka mankhwala ena kuti athetse Gliclazide MV kapena chithandizo chovuta.

Gliclazide MV ndi othandizira kwambiri a hypoglycemic omwe amachepetsa shuga m'magazi pang'ono ndi pang'ono. Ngakhale imakhala ndi zotsutsana ndi zoyipa zina, chiopsezo chosinthika ndi 1%. Wodwala sayenera kudzilimbitsa yekha, adokotala yekha, poganizira zomwe wodwalayo angathe, amatha kupereka mankhwala othandiza. Mankhwalawa a mtundu 2 a shuga mellitus mothandizidwa ndi Gliclazide MV, ndikofunikira kutsatira zakudya zoyenera komanso kukhala ndi moyo wakhama. Chifukwa chake, pakuwona malamulo onse, wodwalayo azitha kusunga matendawa "m'chigoge cha hedgehog" ndikumulepheretsa kuwongolera moyo wake!

Zambiri pa Gliclazide MV zaperekedwa mu kanema mu nkhaniyi.

Glyclazide, malangizo ogwiritsira ntchito (Njira ndi Mlingo)

Mapiritsi a Glyclazide zotchulidwa koyamba tsiku lililonse 80 mg, kumwedwa 2 pa tsiku kwa mphindi 30 asanadye. M'tsogolomu, mlingo umasinthidwa, ndipo pafupifupi tsiku lililonse mumakhala anthu 160 mg, ndipo pazokwanira ndi 320 mg. Mapiritsi a Glyclazide MB amatha kuzindikira mapiritsi otulutsidwa nthawi zonse. Kuthekera kwatsopano ndi kumwa pankhaniyi kumatsimikiziridwa ndi adokotala.

Glyclazide MB 30 mg kumwa 1 nthawi patsiku ladzala. Kusintha kwa mankhwalawa kumachitika pambuyo pa milungu iwiri ya chithandizo. Ikhoza kukhala 90 -120 mg.

Mukaphonya piritsi simungathe kumwa pawiri. Mukalowetsa mankhwala ena ochepetsa shuga ndi izi, nthawi yosinthika sifunikira - amayamba kumwa tsiku lotsatira. Mwina kuphatikiza ndi khwawa, insulinalpha glucosidase zoletsa. Pofatsa pang'ono kulephera kwa aimpso woikidwa chimodzimodzi. Odwala omwe ali pachiwopsezo cha hypoglycemia, mlingo wochepa umagwiritsidwa ntchito.

Mankhwala osokoneza bongo amawonetsedwa ndi zizindikiro za hypoglycemia: mutu, kutopa, kufooka kwambiri, thukuta, palpitations, kuthamanga kwa magazi, arrhythmiakugona chipwirikitiukali, kusakwiya, kuchedwa kuchitapo kanthu, kusawona bwino ndi kuyankhula, kunjenjemerachizungulire kukokana, bradycardiakulephera kudziwa.

Ndi odziletsa hypoglycemiaosazindikira msanga, kuchepetsa kuchuluka kwa mankhwalawo kapena kuwonjezera kuchuluka kwa chakudya choperekedwa ndi chakudya.

M'magawo akulu a hypoglycemic, kugonekedwa kuchipatala mwachangu ndi thandizo ndikofunikira: iv 50 ml ya njira ya 20-30% ya shuga, ndiye 10% dextrose kapena glucose solution ikuwukha. Pakupita masiku awiri, kuchuluka kwa shuga kumayang'aniridwa. Kudina osagwira ntchito.

Ntchito mogwirizana Cimetidinezomwe zimawonjezera chidwi gliclazidezomwe zingayambitse hypoglycemia.

Mukamagwiritsa ntchito Verapamil muyenera kuyang'anira kuchuluka kwa shuga.

Mphamvu ya hypoglycemic imatha kugwiritsidwa ntchito ngati salicylateszotumphukira Pyrazolone, sulfonamides, khofi, Phenylbutazone, Theofylline.

Kugwiritsa ntchito ma beta-blockers osasankha kumawonjezera ngozi hypoglycemia.

Mukamagwiritsa ntchito Acarbosezolembedwa zowonjezera hypoglycemic zotsatira.

Mukamagwiritsa ntchito GCS (kuphatikiza mitundu yakunja yogwiritsira ntchito), barbiturates, okodzetsa, estrogenndi ma progestin, Diphenin, Rifampicinkutsitsa kwa shuga kwa mankhwalawa kumachepa.

Kutentha kopitilira 25 C.

Glidiab MV, Glyclazide-Akos, Diabinax, Diabeteson MV, Diabetesalong, Glucostabil.

Pakadali pano, zotumphukira zimagwiritsidwa ntchito kwambiri. m'badwo II sulfonylureas, komwe Gliclazide ndi yake, chifukwa ndioposa mankhwala am'badwo wapambuyo mwa zovuta za hypoglycemic, popeza chiyanjano cha β-cell receptors ndi nthawi 2-5, zomwe zimapangitsa kukwaniritsa izi mukamapereka milingo yaying'ono. Mbadwo uno wa mankhwalawa suvuta kuyambitsa mavuto.

Chizindikiro cha mankhwalawa ndikuti ma metabolites angapo amapangidwa panthawi ya kusintha kwa kagayidwe kachakudya, ndipo imodzi mwa izo imakhudzanso ma microcirculation. Kafukufuku wambiri wawonetsa chiopsezo chochepetsetsa cha zovuta za microvascular (retinopathyndi nephropathy) mankhwalawa gliclazide. Kukula kumachepa angiopathy, zakudya zamagulu onse zimakhala bwino, zimazimiririka mtima stasis. Chifukwa chake amalembera zovuta matenda ashuga (angiopathy, nephropathyndi matenda oyamba a impso, retinopathies) ndipo izi zimanenedwa ndi odwala omwe, pazifukwa izi, adasinthidwa kuti amwe mankhwalawa.

Ambiri amagogomezera kuti mapiritsi amayenera kumwedwa pambuyo pa chakudya cham'mawa, chomwe chili ndi chakudya chokwanira, kufa ndi njala masana sikuvomerezeka. Kupanda kutero, motsutsana ndi maziko azakudya zochepa zopatsa mphamvu ndikuchita zolimbitsa thupi kwambiri, chitukuko ndichotheka hypoglycemia. Ndi kupsinjika kwakuthupi, ndikofunikira kusintha mlingo wa mankhwalawa. Atamwa mowa, anthu ena amakhalanso ndi mikhalidwe ya hypoglycemic.

Okalamba amamvera kwambiri mankhwala a hypoglycemic, chifukwa chiopsezo chawo chokhala ndi hypoglycemia chikuwonjezeka. Mothandizirana ndi izi, ndi bwino kugwiritsa ntchito mankhwala osakhalitsa (abwinobwino gliclazide).
Odwala amawunika mu malingaliro awo momwe amafunikira kugwiritsa ntchito mapiritsi osinthidwa osinthika: amachita pang'onopang'ono komanso moyenera, motero amagwiritsidwa ntchito kamodzi patsiku. Kuphatikiza apo, mlingo wake wogwira ntchito umakhala wocheperako kawiri kuposa momwe amaperekera gliclazide.

Pali malipoti kuti patadutsa zaka zingapo (kuyambira 3 mpaka 5 kuyambira pachiyambire), kukana kumayamba - kuchepa kapena kusowa kwa kanthu kwa mankhwalawa. Zikatero, adotolo amasankha kuphatikiza kwa ena othandizira a hypoglycemic.

Mutha kugula mankhwalawa mu makampani azachipatala a mizinda yonse ya Russia: Ryazan, Tula, Saratov, Ulyanovsk.

Kodi mankhwalawa amagwira ntchito bwanji?

Zotsatira zam'magazi ndi hypoglycemic. Kuchulukitsa katemera wa insulin ndi maselo a pancreatic beta ndikusintha magwiritsidwe ntchito a shuga. Imalimbikitsa ntchito ya minofu ya glycogen synthetase. Kugwiritsa kagayidwe kachakudya kagayidwe kachakudya matenda a shuga, odwala ndi exogenally kukhazikika kwa kunenepa. Gliclazide amateteza mbiri ya glycemic pambuyo masiku angapo chithandizo.

Glyclazide amafupikitsa nyengo kuyambira nthawi ya kumeza mpaka kuyamba kwa insulin, kubwezeretsanso kuchuluka kwa insulin, ndikuchepetsa hyperglycemia yomwe imayamba chifukwa cha kudya.

Zofunika! Amasintha magawo a hematological, ziwopsezo zamagazi, magazi a heestasis ndi ma cellcirculation.

Gliclazide imalepheretsanso kukula kwa microvasculitis, kuphatikizapo kuwonongeka kwa diso la diso. Imaphatikizira kuphatikiza kwa maselo othandiza magazi kuundana, kumachulukitsa chidziwitso chogwirizana, kumawonjezera heparin ndi fibrinolytic ntchito, kumawonjezera kulolerana kwa heparin. Imawonetsa katundu wa antioxidant, imakweza conjunctival vascularization, imapereka magazi mosalekeza ma microvessels, amachotsa zizindikiro za microstasis.

Mu matenda a shuga a nephropathy, mankhwalawa amachepetsa proteinuria. Mokwanira komanso zotengeka mwachangu kuchokera kugaya chakudya. Mu chiwindi, imadutsa oxidation ndikupanga ma metabolites, omwe amachititsa kutulutsa ma cell. Amayamwa mu mawonekedwe a metabolites ndi mkodzo komanso kudzera m'mimba.

Malangizo atsatanetsatane oti mugwiritse ntchito

Mlingo woyambirira wa odwala omwe ali ndi zaka 65 ndi 80 mg / tsiku, Mlingo wachiwiri wogawanika, kwa odwala azaka zopitilira 65, chithandizo chiyenera kuyamba ndi 40 mg 1 r / tsiku ngati kuli koyenera, kulimbitsa glycemic kuyenera kuwonjezereka. Mlingo wa tsiku ndi tsiku utha kuchuluka mu BPF Fomu Yadziko Lonse, Kutulutsa 60).

Ndikulimbikitsidwa kuti mukulitse mlingo ndi masiku osachepera 14, muyezo wa tsiku ndi tsiku ndi 80-240 mg pamiyeso iwiri, muyezo Mlingo wa 160 mg / tsiku la BNF mu Mlingo wachiwiri, mlingo waukulu wa tsiku ndi tsiku ndi 320 mg wa BNF Glyclazide mu Mlingo iwiri.

Mapiritsi otulutsidwa osinthika, mlingo woyambira ndi 30 mg. Mlingo wa tsiku ndi tsiku ndi 30-120 mg, mlingo wa tsiku ndi tsiku amatengedwa kamodzi pakudya kadzutsa.

Mapiritsi ayenera kumezedwa lonse, ngati pakufunika kulimbikitsa kuyendetsa glycemia, tsiku lililonse mlingo utha kuwonjezeka mpaka 60 mg, 90 mg kapena 120 mg kamodzi pakudya kadzutsa, tikulimbikitsidwa kuti muwonjezere mlingo pang'onopang'ono, pakadutsa mwezi umodzi, pokhapokha ngati panali kuchepa kwa shuga m'magazi magazi mkati mwa masabata awiri achithandizo.

Muzochitika zotere, mlingo umatha kuchuluka pambuyo pa masabata awiri a chithandizo, pafupifupi tsiku lililonse 60 mg / tsiku kamodzi.

Zofunika! Musanaonjezere mankhwala tsiku lililonse, funsani dokotala.

Nthawi ya chakudya cham'mawa, kwa odwala ambiri kuyambira koyambirira kwa chithandizo, muyezo wapiritsi ya tsiku lililonse ndi 120 mg 1 piritsi. (Mapiritsi) ndi kusintha kosinthika kwa mankhwala 60 mg ndi ofanana ndi mapiritsi awiri omwe amasulidwa ndi mankhwala 30 mg patebulo.

Mapiritsi okhala ndi masinthidwe osinthidwa a 60 mg ali pansi pa gawo, zomwe zimapangitsa kugwiritsa ntchito mankhwalawa pa mlingo wa 30 mg (1/2 tebulo.) Ndi mlingo wa 90 mg (1.5 gome.)

Kusamutsa wodwala kuchokera kukonzekera komwe kumakhala ndi Glyclazide 80 mg kukonzekera komwe kumakhala mapiritsi a Gliclazide 60 mg osinthika: piritsi limodzi la Glyclazide 80 mg limafanana ndi 1/2 piritsi. mankhwalawa ndi 60 mg.

Momwe mungatengere panthawi yoyembekezera

Pa nthawi yoyembekezera, Glyclazide imaphatikizidwa, chifukwa chake nthawi imeneyi ndi mkaka wa m'mawere ndiyabwino kwambiri.

Komanso pa nthawi ya pakati, mkhalidwe wololera wa glucose ungachitike, zomwe zingayambitse zotsatira zoyipa kwambiri mukamagwiritsa ntchito Glyclazide panthawi yapakati. Chifukwa chake, mukakhala ndi pakati, ndikofunikira kuchita kuyesa kwa glucose.

Pa matenda ashuga, ndikofunikira kwambiri kuyang'anira kuchuluka kwa shuga m'magazi, omwe amathandizidwa ndi glucometer, omwe amafotokozedwa mwatsatanetsatane munkhani "Kufotokozera kwathunthu kwa Accu-Chek Active glucometer".

Mimba komanso kuyamwa

Palibe zokuchitikirani ndi kuikidwa kwa Gliclazide MV kwa amayi apakati. Kafukufuku wazinyama sanatsimikizire kupezeka kwa zotsatira za teratogenic pazinthu izi. Ndi chiphuphu chosakwanira cha matenda a shuga mellitus panthawi ya chithandizo, pali chiwopsezo chowonjezereka cha kubereka kosabereka mu fetus, komwe kumatha kuchepetsedwa ndikuwongolera koyenera kwa glycemic. M'malo mwa gliclazide mwa amayi apakati, tikulimbikitsidwa kugwiritsa ntchito insulin, yemwenso ndi mankhwala osankhidwa kwa odwala omwe akukonzekera kutenga pakati, kapena iwo omwe ali ndi pakati panthawi yochizidwa ndi Gliclazide MV.

Popeza palibe chidziwitso pakudya kwa yogwira pophika mu mkaka wa m'mawere, ndipo mwa akhanda kumene pamakhala chiwopsezo chokhala ndi neonatal hypoglycemia, kutenga Gliclazide MB pa mkaka wa m`mawere amatsutsana.

Zotsatira zoyipa ndi bongo

Kuchokera m'mimba, Glyclazide imatha kuyambitsa: kawirikawiri - anorexia, nseru, kusanza, kutsekula m'mimba, kupweteka kwa epigastric.
Kuchokera ku hemopoietic system: nthawi zina - thrombocytopenia, agranulocytosis kapena leukopenia, kuchepa magazi (nthawi zambiri kumatha kusintha).
Kuchokera endocrine dongosolo: ndi bongo - hypoglycemia.
Thupi lawo siligwirizana: zotupa pakhungu, kuyabwa.

Mankhwala osokoneza bongo akuwonetsedwa ndi zizindikiro za hypoglycemia: kupweteka mutu, kutopa, kufooka kwambiri, thukuta, kukwiya, kukwiya, kusachedwa, kuchitapo kanthu, kusawona bwino kwa malankhulidwe ndi kulankhula, kunjenjemera, chizungulire, kukomoka.

Chizindikiro chimodzi chowopsa ndi chikomokere.

Zofunika! Mukamagwiritsa ntchito mankhwala osokoneza bongo, muyenera kuwunika momwe zinthu zilili.

Ndi hypoglycemia wofatsa popanda kumva kukomoka, kuchepetsa mlingo wa mankhwalawo kapena kuwonjezera kuchuluka kwa chakudya choperekedwa ndi chakudya.

Analogi ndi mtengo

Ma analogi a Gliclazide ndi:

Vero-Glyclazide,
Glidiab
Glidiab MV,
Glisid
Gliclazide MV,
Glyclazide-Akos,
Zamakolo
Gulcostabil,
Mdyerekezi
Diabetesalong
Diabetes
Diabeteson MV,
Diabefarm
Diabefarm MV,
Diabinax
Mdyerekezi
Zolemba
Medoclacid
Predian
Sinthani.

Mutha kugula mankhwalawo m'mankhwala am'mizinda yonse ya Russia.

Glyclazide MV 30 mg ingagulidwe kwa ma ruble a 115-147.

Chifukwa cha nkhaniyi, mutha kuphunzira zambiri zamankhwala amitundu yatsopano ya matenda ashuga II.

Ndemanga Zahudwala

Pakadali pano, zotumphukira za sulfonylureas zam'badwo wachiwiri, zomwe Glyclazide ndi yake, zimagwiritsidwa ntchito kwambiri chifukwa ndizabwino kwambiri kuposa m'badwo wam'mbuyomu mu hypoglycemic effect, popeza chiyanjano cha β-cell receptors ndi nthawi 2-5, zomwe zimapangitsa kukwaniritsa zomwe amapereka . Mbadwo uno wa mankhwalawa suvuta kuyambitsa mavuto.

Zofunika kudziwa! Komanso, chifukwa cha Glyclazide, kuopsa kwa angiopathies kumachepa, thanzi la conjunctiva limayenda bwino, ndipo mtima wamisala umatha.

Ichi ndichifukwa chake amalembera zovuta za matenda osokoneza bongo a shuga (angiopathy, nephropathy okhala ndi vuto loyambirira la impso, retinopathy) ndipo izi zimanenedwa ndi odwala omwe, chifukwa chaichi, adasamutsidwa kuti alandire mankhwalawa.

Ndi kupsinjika kwakuthupi, ndikofunikira kusintha mlingo wa mankhwalawa. Atamwa mowa, anthu ena amakhalanso ndi mikhalidwe ya hypoglycemic.

Okalamba amamvera kwambiri mankhwala a hypoglycemic, chifukwa chiopsezo chawo chokhala ndi hypoglycemia chikuwonjezeka. Mothandizirana ndi izi, ali bwino kugwiritsa ntchito mankhwala osokoneza bongo (gliclazide nthawi zonse).

Odwala amawunika mu malingaliro awo momwe amafunikira kugwiritsa ntchito mapiritsi osinthika osinthika: amachita pang'onopang'ono komanso moyenera, kotero, amagwiritsidwa ntchito kamodzi patsiku.Kuphatikiza apo, mlingo wake wogwira ntchito umakhala wocheperako kawiri kuposa 2 mgulu la gliclazide.

Pali malipoti kuti patadutsa zaka zingapo (kuyambira 3 mpaka 5 kuyambira pachiyambire), kukana kumayamba - kuchepa kapena kusowa kwa kanthu kwa mankhwalawa. Zikatero, adotolo amasankha kuphatikiza kwa ena othandizira a hypoglycemic.

Zofunika! Mukamagwiritsa ntchito Glyclazide, monga mankhwala ena aliwonse, muyenera kufunsa dokotala.

Monga chowonjezera chothandiza kwa odwala matenda ashuga amtundu wachiwiri, kuphatikiza ndi zakudya zoyenera, imagwira bwino ntchito. Ndimamva bwino komanso ndikuwoneka bwino, ndimakonda mtengo komanso kusapezeka kwa zoyambitsa, zotsatira zenizeni.

Chabwino, shuga samachepetsa. Ndinkamwa mayunitsi 30, shuga sanatsike, koma anawonjezeka. Ndinayamba kumwa mayunitsi 60. kugunda kwamtima kwamphamvu kunayamba, kupanikizika kunadzuka. Panalibe mankhwala enaake apabe. Ndipo ena sapezeka. Chifukwa chake mumadzigulira nokha mankhwala ena.

Kuyanjana kwa mankhwala osokoneza bongo

Ndi kuphatikiza kwa Gliclazide MV ndi mankhwala ena osokoneza bongo, zotsatirapo zosavomerezeka zingachitike:

Pyrazolone derivatives, salicylates, phenylbutazone, antibacterial sulfonamides, theophylline, caffeine, monoamine oxidase inhibitors (MAOs): kuthekera kwa hypoglycemic zotsatira za glyclazide,
Osasankha beta-blockers: kuchuluka kwa hypoglycemia, kuchuluka thukuta ndi chigoba cha tachycardia ndi kugwedezeka kwa dzanja mwamphamvu kwa hypoglycemia,
Gliclazide ndi acarbose: kuchuluka kwa hypoglycemic,
Cimetidine: kuchuluka plasma gliclazide ndende (kwambiri hypoglycemia ingayambike, kuwonetseredwa mu mawonekedwe a kupsinjika kwa chapakati mantha dongosolo ndi kusokonezeka chikumbumtima),
Glucocorticosteroids (kuphatikizapo mitundu yakunja ya mankhwalawa), diuretics, barbiturates, estrogens, progestin, mankhwala a estrogen-progestogen, diphenin, rifampicin: kuchepa kwa hypoglycemic zotsatira za glycazide.

Zofanizira za Gliclazide MV ndi: Gliclazide-Akos, Glidiab, Glidiab MV, Glucostabil, Diabeteson MV, Diabefarm MV, Diabinax, Diabetalong.

Ndemanga pa Gliclazide MV

Gliclazide MV ndi gawo limodzi la zigawo zachiwiri za sulfonylurea ndipo amadziwika kwambiri ndi vuto la hypoglycemic, lomwe limalongosoleredwa ndi mgwirizano wapamwamba wa β-cell receptors (nthawi 2-5 nthawi yayitali kuposa m'mibadwo yam'mbuyomu). Izi zimakuthandizani kuti mukwaniritse zochizira zowonjezera pamlingo wochepetsetsa komanso kuchepetsa kuchuluka kwa zoyipa.

Malinga ndi ndemanga, MV Gliclazide imagwiritsidwa ntchito pamavuto a shuga mellitus (retinopathy, nephropathy poyambira matenda aimpso kulephera, angiopathy. Izi zimanenedwa ndi odwala omwe asamutsidwa kuti alandire mankhwalawa. Izi ndichifukwa choti imodzi mwazigawo za glycazide metabolites imakhudza ma microcirculation ambiri, kuchepetsa kuopsa kwa angiopathy komanso chiopsezo chokhala ndi zovuta zam'magazi (nephropathy ndi retinopathy). Nthawi yomweyo, kuthamanga kwa magazi mu conjunctiva kumathandizanso komanso kupindika kwamisempha kumatha.

Akatswiri ambiri amagogomezera kuti mukamalandira chithandizo ndi Gliclazide MV, ndikofunikira kupewa kufa ndi njala ndikupatsa zakudya zomwe zili ndi zakudya zamagulu ambiri. Kupanda kutero, potengera zakudya zama calorie ochepa komanso pambuyo pakuchita zolimbitsa thupi kwambiri, wodwala amatha kukhala ndi hypoglycemia. Ndi kupsinjika kwakuthupi, kusintha kwa mankhwala kumafunika. Mwa odwala ena, atamwa mowa panthawi ya mankhwala a Gliclazide MV, zizindikiro za hypoglycemia zinaonekeranso.

Gliclazide MV siyikulimbikitsidwa kuti izigwiritsidwa ntchito mwa odwala okalamba omwe amatha kukhala ndi hypoglycemia, chifukwa chake, motere, ndikofunikira kugwiritsa ntchito mankhwala ofupikitsa.

Odwala amadziwa kuphweka kwa kugwiritsa ntchito gliclazide mwa mapiritsi osinthika osinthika: amayamba pang'onopang'ono, ndipo gawo lolimbikira limagawidwa mthupi lonse. Chifukwa cha izi, mankhwalawa amatha kumwa 1 nthawi patsiku, ndipo mankhwalawa ndi othandizira kawiri kuposa kawiri a gliclazide. Palinso malipoti oti atatenga nthawi yayitali mankhwala (zaka 3-5 kuyambira chikhazikitso), odwala ena adayamba kukana, zomwe zimafuna kuti pakhale mankhwala ena ochepetsa shuga.

Mlingo

30 mg ndi 60 mg mapiritsi osinthidwa otulutsidwa

Piritsi limodzi lili:

ntchito yogwira - gliclazide 30.0 mg kapena 60.0 mg,

zokopa: silicon diokosi woipa wa m'magazi, hydroxypropyl methylcellulose, sodium stearyl fumarate, talc, lactose monohydrate.

Mapiritsi ndi oyera kapena pafupifupi oyera, owoneka bwino ngati cylindrical lapansi ndi bevel (mlingo wa 30 mg).

Mapiritsi ndi oyera kapena pafupifupi oyera mtundu, ozungulira mawonekedwe ndi mawonekedwe a cylindrical, facet ndi notch (Mlingo wa 60 mg).

Mankhwala

Pharmacokinetics

Pambuyo pakamwa, gliclazide imadzaza kwathunthu kuchokera kumimba. Kudya sizimakhudza kuchuluka kwa mayamwidwe. Kuchulukana kwa gliclazide mu plasma kumawonjezeka pang'onopang'ono mkati mwa maola 6 atatha kukhazikitsa ndikufika kumapanga omwe akupitilira kuyambira 6 mpaka 12 ora. Kusintha kwamitundu iwiri ndiocheperako. Ubale pakati pa mlingo mpaka 120 mg ndi plasma yokhotakhota ya mankhwalawa ndi njira yodalira nthawi. Pafupifupi 95% ya mankhwalawa amamangiriza mapuloteni a plasma.

Gliclazide imapangidwa makamaka mu chiwindi ndipo imapukusidwa makamaka mkodzo. Excretion imachitika makamaka ndi impso mu mawonekedwe a metabolites, ochepera 1% amachotsedwa osasinthika mumkodzo. Palibe metabolites yogwira mu plasma.

Hafu ya moyo (T1 / 2) wa gliclazide pafupifupi maola 16 (maola 12 mpaka 20).

Okalamba, palibe kusintha kwakukulu pama paracminetic paraceter.

Mlingo wa tsiku limodzi wa 60 mg umathandiza kugwiriridwa kwa plasma kwa maola oposa 24.

Mankhwala

Gliclazide MV ndi mankhwala osokoneza bongo a hypoglycemic ochokera ku gulu la II m'badwo wa sulfonylurea, omwe amasiyana ndi mankhwala omwewo mwa kukhalapo kwa mphete ya Nter heterocyclic yokhala ndi chomangira cha endocyclic.

Gliclazide MB imachepetsa shuga m'magazi ndikulimbikitsa chinsinsi cha insulin ndi β-maselo a islets a Langerhans. Pambuyo pa chithandizo cha zaka 2, odwala ambiri akadali ndi chiwopsezo cha postprandial insulin ndi secretion ya C-peptides.

Mtundu wachiwiri wa matenda a shuga, mankhwalawa amabwezeretsa chiyambi champhamvu cha insulin chifukwa cha kuchuluka kwa glucose ndikuwonjezera gawo lachiwiri la insulin secretion. Kuwonjezeka kwakukulu kwa insulin katulutsidwe kumawonedwa poyankha kukondoweza chifukwa cha zakudya zomwe amapatsa ndi shuga.

Gliclazide MV imakhudzanso ma microcirculation. Amachepetsa chiopsezo cha chotupa chama magazi (thrombosis) yam'magazi, kukhudza njira ziwiri zomwe zingakhudzidwe ndikupanga zovuta m'matenda a shuga: kusakanikirana kwakanthawi kwa kupatsidwa kwa zinthu za m'magazi komanso kutsekeka komanso kuchepa kwa kugwiritsidwa ntchito kwa zinthu zamagulu a cell (beta-thromboglobulin, thromboxane B2), komanso kubwezeretsa ntchito ya fibrinolytic mtima endothelium ndi kuchuluka kwa minofu plasminogen activator.

Mlingo ndi makonzedwe

Zokhudza pakamwa. Mankhwalawa amangogwiritsidwa ntchito pochiza akuluakulu.

Mlingo wa tsiku ndi tsiku wa MV Glyclazide ukhoza kusiyana 30 mg mpaka 120 mg. Ndikulimbikitsidwa kuti muthe kamodzi pa tsiku mukamadyetsa kadzutsa, kumeza piritsi lonse popanda kutafuna.

Ngati mungadumphe kumwa mankhwalawa, simungathe kuwonjezera mlingo tsiku lotsatira.

Monga mankhwala ena a hypoglycemic, muyeso wa mankhwalawa nthawi iliyonse uyenera kusankhidwa payekhapayekha, kutengera momwe wodwalayo amagwirira ntchito.

Mlingo woyambira wabwino ndi 30 mg tsiku lililonse.

Pankhani yogwiritsa ntchito bwino kuchuluka kwa shuga m'magazi, mankhwalawa angagwiritsidwe ntchito ngati mankhwala ochizira.

Ngati palibe utsogoleri wokwanira wama glucose, muyezo mulingo ungakulitse pang'onopang'ono mpaka 60 mg, 90 mg kapena 120 mg patsiku. Mlingo pakati pakubwera mosiyanasiyana muyezo wa mankhwalawa uyenera kukhala osachepera mwezi umodzi, pokhapokha magazi a shuga sawonjezeka pambuyo pa milungu iwiri. Zikatero, mlingowo ungathe kuwonjezereka kale masabata awiri atayamba chithandizo.

Pazipita la tsiku lililonse lofika 120 mg.

Kusintha kuchokera ku mankhwala ena a hypoglycemic kupita ku MV Gliclazide

Pakusintha, muyezo komanso theka la moyo wam'mbuyomu uyenera kuganiziridwanso. Nthawi yosintha nthawi zambiri sikufunikira. Glyclazide MV kudya uyenera kuyambitsidwa ndi 30 mg, ndikutsatira ndikusintha malinga ndi momwe metabolic anachita.

Posintha kuchokera ku mankhwala ena a gulu la sulfonylurea ndi moyo wautali wa moyo, kuti mupewe kuwonjezereka kwa mankhwalawa, nthawi yosagwiritsa ntchito masiku angapo ingafunike. Zikatero, kusintha kwa mapiritsi a Glyclazide MV kuyenera kuyamba ndi mlingo woyambirira wa 30 mg, kenako ndikuwonjezereka kwa mlingo kutengera metabolic reaction.

Gwiritsani ntchito limodzi ndi mankhwala ena a antidiabetes

Gliclazide MB ikhoza kugwiritsidwa ntchito limodzi ndi Biguanides, alpha-glucosidase inhibitors kapena insulin. Odwala omwe shuga ya m'magazi ake sawongolera mokwanira potenga Gliclazide MV, munthawi yomweyo mankhwala a insulin atha kuyang'aniridwa ndi dokotala.

Okalamba (woposa zaka 65)

Mlingo woyenera wa mankhwala kwa achikulire ndi wofanana ndi akulu kwa zaka zosakwana 65.

Mlingo woyenera wa mankhwala aimpso kulephera kufatsa pang'ono pang'ono ali ofanana ndi anthu omwe ali ndi vuto laimpso.

Odwala Pangozi Yambiri ya Hypoglycemia

Ngati osakwanira kapena osayenera zakudya, mu kwambiri kapena bwino kulipidwa endocrine matenda (hypopituitarism, hypothyroidism, kusakwanira kwa adrenocorticotropic timadzi, atatha kalekale ndi / kapena yayikulu mlingo corticosteroid mankhwala, mu mtima kwambiri matenda (kwambiri mawonekedwe a mtima matenda, kuphwanya kwambiri patency ya carotid kusokoneza mitsempha), tikulimbikitsidwa kupereka mankhwala osachepera 30 mg tsiku lililonse.

Zochita zamankhwala osokoneza bongo

Mankhwala omwe amalimbikitsa mphamvu ya Gliclazide MV (chiwopsezo chowonjezeka cha hypoglycemia)

Miconazole (akaperekedwa mwadongosolo kapena kugwiritsidwa ntchito kwa mucosa wamkati mwa mawonekedwe a gel): imakulitsa mphamvu ya hypoglycemic ya MV Gliclazide (hypoglycemia imatha kukhala mpaka hypoglycemic coma.

Zosavomerezeka kuti zigwiritsidwe:

Phenylbutazone imawonjezera mphamvu ya hypoglycemic ya zotumphukira za sulfonylurea (zimawachotsa kuti asalumikizane ndi mapuloteni a plasma komanso / kapena amachepetsa mayeso awo kuchokera mthupi).

Ndikofunika kugwiritsa ntchito mankhwala ena odana ndi kutupa.

Mowa umachulukitsa hypoglycemia, kupewetsa mphamvu zamagetsi, zimathandizira kukulitsa kukomoka kwa hypoglycemic.

Ndikofunikira kusiya kumwa mowa ndi kumwa mankhwala, monga mowa.

Kuphatikiza komwe kumafunikira kuchenjeza:

Kugwiritsa ntchito pamodzi mankhwala otsatirawa kungakulitse kuchuluka kwa mankhwala a Gliclazide MV ndipo nthawi zina kumayambitsa hypoglycemia:

othandizira ena odwala matenda a shuga (ma insulins, acarbose, biguanides), opanga ma beta, fluconazole, angiotensin-otembenuza enzyme inhibitors (Captopril, enalapril), H2 receptor antagonists, osasinthika a monoamine oxidase inhibitors (MAO I), sulfonamides ndi mankhwala osapweteka a antiidal.

Mankhwala ofooketsa a Glyclazide MV

Zosavomerezeka kuti zigwiritsidwe:

Kugwiritsa ntchito limodzi ndi danazol osavomerezeka chifukwa chakuwonjezeka kwa glucose wamagazi. Ngati nkosatheka kukana kugwiritsa ntchito danazol, fotokozerani wodwalayo kufunika kolamulira kuchuluka kwa shuga m'magazi ndi mkodzo. Nthawi zina pamafunika kusintha mlingo wa Gliclazide MV nthawi ya mankhwala a danazol kapena pambuyo pa danazol.

Kuphatikiza komwe kumafunikira kuchenjeza:

Chlorpromazine mu Mlingo wambiri (zoposa 100 mg patsiku) amawonjezera kuchuluka kwa shuga m'magazi, kuchepetsa kubisalira kwa insulin.

Glucocorticosteroids (ofunikira komanso am'deralo: intraarticular, khungu ndi rectal management) ndi tetracosactrin kuwonjezera magazi ndi kuthekera kwa ketoacidosis, chifukwa cha kuchepa kwa kulekerera kwa chakudya ndi glucocorticosteroids.

β2-adrenostimulants - ritodrin, salbutamol, terbutaline (kugwiritsa ntchito kwadongosolo) kumapangitsa kuchuluka kwa shuga.

Yang'anani makamaka pakufunika kwakudziyang'anira nokha shuga. Ngati ndi kotheka, sinthani wodwala kupita ku insulin.

Ngati mukufuna kugwiritsa ntchito mitunduyi pamwambapa, muyenera kuyang'anira kwambiri kuchuluka kwa shuga m'magazi. Pangakhale kofunikira kuwonjezera pakusintha kwa MV Glyclazide onse munthawi yophatikiza mankhwala atasiya kumwa mankhwala ena.

Kuphatikizika kwa Gliclazide MV ndi mankhwala opatsirana (warfarin, etc.) kungayambitse kuwonjezeka kwa anticoagulant ya mankhwalawa. Kusintha kwa mankhwalawa kwa anticoagulant kungafunike.

Wogwirizira Sitifiketi Yoyang'anira

JLLC "Lekpharm", Republic of Belarus, 223141, Logoysk, ul. Minskaya, 2a, tel / fax: +375 1774 53 801, imelo: [email protected]

Adilesi ya bungweli kuvomereza zofunsidwa kwa ogula pamsika wazogulitsa zomwe zili mdera la Republic of Kazakhstan

Woimira ofesi ya Lekpharm COOO ku Republic of Kazakhstan,

050065, Republic of Kazakhstan, Almaty, m'chigawo cha Almaly, ul. Kazybek bi, d. 68/70, ngodya ya st. Nauryzbay batyr, tel. 8 (727) -2676670, fakisi 8 (727) -2721178

Dzinalo, adilesi ndi zambiri zokhudzana ndi (foni, fakisi, imelo) ya bungwe lomwe lili kudera la Republic of Kazakhstan lomwe limayang'anira kuwongolera kwa chitetezo cha mankhwala

Woimira ofesi ya Lekpharm COOO ku Republic of Kazakhstan,

050065, Republic of Kazakhstan, Almaty, dera la Almaly, ul. Kazybek bi, d. 68/70, ngodya ya st. Nauryzbay batyr, tel. 8 (727) -2676670, fakisi 8 (727) -2721178,