Insulin kukana ndi kusokonezeka kwachilengedwenso mayankho a thupi insulin. Zilibe kanthu kuti insulin imachokera kuti, kapamba (amkati) kapena jakisoni (wakunja).

Kukana kwa insulin kumawonjezera mwayi wokhala ndi matenda a shuga a 2 okha, komanso atherosclerosis, vuto la mtima, komanso kufa mwadzidzidzi chifukwa cha chotengera cholumikizidwa.

Kuchita kwa insulin ndikuwongolera kagayidwe (osati chakudya chokha, komanso mafuta ndi mapuloteni), komanso njira za mitogenic - uku ndikokula, kubadwanso kwa maselo, kaphatikizidwe ka DNA, kapangidwe ka majini.

Lingaliro lamakono la kukana insulini sikungokhala ndi zovuta za carbohydrate metabolism komanso chiopsezo chowonjezeka cha matenda a shuga a 2. Zimaphatikizanso kusintha kwa kagayidwe ka mafuta, mapuloteni, mafotokozedwe a jini. Makamaka, kukana insulini kumabweretsa mavuto ndi maselo a endothelial omwe amaphimba makhoma amitsempha yamagazi kuchokera mkati. Chifukwa cha izi, kuunikira kwa ziwiya kumachepa, ndipo atherosulinosis imayamba.

Zizindikiro za insulin kukaniza ndi kuzindikira

Mutha kukayikira kukana insulini ngati zizindikiro ndi / kapena kuyesa zikuwonetsa kuti muli nacho. Mulinso:

• kunenepa kwambiri m'chiuno (pamimba),
• kuyezetsa magazi koyipa kwa cholesterol ndi triglycerides,
• kudziwika kwa mapuloteni mumkodzo.

Kunenepa kwambiri pamimba ndicho chizindikiro chachikulu. Kachiwiri ndi ochepa matenda oopsa (kuthamanga kwa magazi). Pafupipafupi, munthu samakhala ndi kunenepa kwambiri komanso matenda oopsa, koma kuyezetsa magazi kwa cholesterol ndi mafuta kumakhala koyipa kale.

Kuzindikira kukana insulini pogwiritsa ntchito mayeso kumakhala kovuta. Chifukwa kuchuluka kwa insulin m'madzi a m'magazi kumatha kusiyanasiyana, ndipo izi sizachilendo. Mukamayang'ana insulin yotsalira ya plasma, mankhwalawa amachokera 3 mpaka 28 mcU / ml. Ngati insulini yachilendo kuposa kusala kudya kwa magazi, zikutanthauza kuti wodwalayo ali ndi hyperinsulinism.

Kuchulukana kwakukulu kwa insulini m'magazi kumachitika pamene kapamba amatulutsa owonjezera kuti athe kulipirira insulin kukana. Zotsatira zakuwonetseraku zikuwonetsa kuti wodwalayo ali ndi chiopsezo chachikulu cha matenda a shuga a 2 komanso / kapena mtima.

Njira yeniyeni yovomerezeka yodziwira matenda a insulin imatchedwa hyperinsulinulin insulin clamp. Zimaphatikizapo kulowetsedwa kosalekeza kwa insulin ndi shuga kwa maola 4-6. Iyi ndi njira yotopetsa, chifukwa chake sagwiritsidwa ntchito kwenikweni pochita. Amangolekezera kuyesa magazi magazi chifukwa cha plasma insulin.

Kafukufuku wasonyeza kuti kukana insulini kumapezeka:

• 10% ya anthu onse opanda zovuta zama metabolic,
• mu 58% ya odwala matenda oopsa (kuthamanga kwa magazi kuposa 160/95 mm Hg),
• mwa 63% ya anthu omwe ali ndi hyperuricemia (seramu uric acid imaposa 416 μmol / l mwa amuna ndipo oposa 387 μmol / l mwa akazi),
• mu 84% ya anthu omwe ali ndi mafuta ambiri am'magazi (triglycerides opitilira 2.85 mmol / l),
• mwa 88% ya anthu okhala ndi cholesterol yabwino “yabwinobwino” (m'munsimu 0,9 mmol / l mwa amuna ndi otsika 1.0 mmol / l mwa azimayi),
• mu 84% ya odwala matenda a shuga a 2,
• 66% ya anthu omwe ali ndi vuto loleza shuga.

Mukakayezetsa magazi a cholesterol - osayang'ana cholesterol yathunthu, koma payokha "zabwino" ndi "zoyipa".

Momwe insulin imayang'anira kagayidwe

Nthawi zambiri, molekyulu ya insulin imamangiriza ku cholandilira chake pamwamba pamaselo a minofu, mafuta, kapena minyewa ya chiwindi.Pambuyo pa izi, autophosphorylation ya insulin receptor ndi gawo la tyrosine kinase ndi mgwirizano wotsatira ndi gawo lapansi la insulin receptor 1 kapena 2 (IRS-1 ndi 2).

Ma molekyulu a IRS, nawonso, amachititsa phosphatidylinositol-3-kinase, omwe amachititsa kuti GilUT-4 isamutsidwe. Ndionyamula glucose kulowa mu cell kudzera mu nembanemba. Njira iyi imapereka kutseguka kwa kagayidwe kazakudya (glucose transport, glycogen synthesis) ndi mitogenic (synthesis wa DNA) wa insulin.

• Kutenga kwa glucose ndimaselo am'misempha, chiwindi ndi minofu ya adipose,
• Kaphatikizidwe ka glycogen m'chiwindi (kusungidwa kwa glucose "othamanga"),
• Kulanda kwa ma amino acid ndimaselo,
• Kaphatikizidwe ka DNA
• Mapuloteni
• Mafuta acid mafuta
• Kutumiza kwa Ion.

• Lipolysis (kusweka kwa minofu ya adipose ndi kulowa kwamafuta acid m'magazi),
• Gluconeogenesis (kusintha kwa glycogen mu chiwindi ndi glucose m'magazi),
• Apoptosis (kudziwononga kwa maselo).

Dziwani kuti insulini imalepheretsa kuchepa kwa minofu ya adipose. Ndiye chifukwa chake, ngati mulingo wa insulin m'mwazi ukakwezedwa (hyperinsulinism imachitika kawirikawiri ndikulimbana ndi insulin), ndiye kuti kuchepetsa thupi kumakhala kovuta kwambiri, mwinanso kosatheka.

Mitundu imayambitsa kukana insulini

Kukana kwa insulin ndi vuto la kuchuluka kwakukulu kwa anthu onse. Amakhulupirira kuti amayamba chifukwa cha majini omwe adayamba kukhala ambiri panthawi ya chisinthiko. Mu 1962, zidadziwika kuti iyi ndi njira yopulumutsira chakudya nthawi yayitali. Chifukwa imathandizira kudzikundikira kwamafuta m'thupi munthawi yazakudya zambiri.

Asayansi akhala ndi njala kwa nthawi yayitali. Omaliza kupulumuka ndi omwe adapezeka kuti ali ndi chibadwa chokhala ndi insulin. Tsoka ilo, masiku ano, njira imodzimodziyo "imagwira ntchito" pakupanga kunenepa kwambiri, matenda oopsa, komanso matenda a shuga 2.

Kafukufuku akuwonetsa kuti odwala omwe ali ndi matenda amtundu wa 2 ali ndi vuto lakumtunduwu pakufalitsira chizindikiro atalumikiza insulin ku receptor yawo. Izi zimatchedwa zolakwika za postreceptor. Choyamba, kusamutsidwa kwa glucose transporter GLUT-4 kumasokonezedwa.

Odwala omwe ali ndi matenda a shuga a mtundu wachiwiri, kufooka kwa mitundu ina yopereka kagayidwe kazakudya ndi lipids (mafuta) anapezekanso. Awa ndi majini a glucose-6-phosphate dehydrogenase, glucokinase, lipoprotein lipase, mafuta acid synthase ndi ena.

Ngati munthu ali ndi chibadwa chokhala ndi matenda amtundu wa 2, ndiye kuti amatha kuzindikira kapena osayambitsa matenda ashuga. Zimatengera moyo. Zomwe zimayambitsa chiopsezo chachikulu ndimakudya ochulukirapo, makamaka kumwa mafuta osakanikirana (shuga ndi ufa), komanso masewera olimbitsa thupi ochepa.

Kodi chidwi chokhudza insulini m'matupi osiyanasiyana a thupi

Pazithandizo zamatenda, kumva kwa insulin kwa minofu ndi minyewa ya adipose, komanso maselo a chiwindi, ndikofunikira kwambiri. Koma kodi kuchuluka kwa insulin kukokana ndi izi zimakhala chimodzimodzi? Mu 1999, kuyesa kunawonetsa kuti ayi.

Nthawi zambiri, kupondereza 50% ya lipolysis (kuchepa kwamafuta) mu minofu ya adipose, kuchuluka kwa insulin m'magazi osaposa 10 mcED / ml ndikokwanira. Kuti 50% yoletsa kutulutsidwa kwa glucose m'mwazi ndi chiwindi, pafupifupi 30 mcED / ml ya insulin m'magazi ikufunika kale. Ndipo kuti muwonjezere kutuluka kwa glucose pogwiritsa ntchito minofu ya 50%, kufunikira kwa insulini m'magazi a 100 mcED / ml ndiwofunikira ndikofunikira.

Tikukumbutsani kuti lipolysis ndikuphwanya kwa adipose minofu. Kuchita kwa insulin kumachepetsa, komanso kupanga shuga ndi chiwindi. Ndipo minofu ya glucose imachitika ndi insulin, m'malo mwake, imachulukitsidwa. Chonde dziwani kuti mu mtundu 2 wa matenda ashuga, malingaliro ofunikira a insulin m'magazi amasinthidwa kumanja, i.e., pakukulira kwa insulin. Njirayi imayamba kalekale shuga asanadziwike.

Kuzindikira kwa minofu ya thupi kupita ku insulin kumachepa chifukwa cha chibadwa chamtsogolo, ndipo koposa zonse - chifukwa cha moyo wopanda thanzi.Mapeto ake, patatha zaka zambiri, kapamba amasiya kulimbana ndi nkhawa zambiri. Kenako amapeza matenda a shuga enieni. Ndikothandiza kwambiri kwa wodwala ngati chithandizo cha metabolic syndrome chayambika mofulumira.

Kodi pali kusiyana kotani pakati pa insulin kukokana ndi metabolic syndrome

Mukuyenera kudziwa kuti kukana insulin kumachitika mwa anthu omwe ali ndi mavuto ena azaumoyo omwe samaphatikizidwa ndi lingaliro la "metabolic syndrome". Izi ndi:

• polycystic ovary mwa akazi,
• aakulu aimpso kulephera
• matenda opatsirana
• glucocorticoid mankhwala.

Kukana kwa insulin nthawi zina kumachitika pakubala, ndipo kumadutsa pakubadwa kwa mwana. Amadziwikanso zaka. Ndipo zimatengera mtundu wamakhalidwe omwe munthu wokalamba amatsogolera, ngakhale kuti zingayambitse matenda ashuga a 2 komanso / kapena mtima. M'nkhani "" "mupeza zambiri zothandiza.

Zomwe zimayambitsa matenda a shuga 2

Mtundu wachiwiri wa matenda a shuga, kutsutsana kwa insulin, minyewa, chiwindi ndi minyewa ya adipose ndikofunikira kwambiri pakuchipatala. Chifukwa cha kuchepa kwa chidwi ndi insulini, shuga wochepa amalowa ndikutentha mu maselo a minofu. Mu chiwindi, pachifukwa chomwechi, kuwonongeka kwa glycogen kuti glucose (glycogenolysis) adamulowetsa, komanso kapangidwe ka glucose kuchokera ku amino acid ndi zina "zopangira" (gluconeogenesis).

Kukana kwa insulin kwa minofu ya adipose kumawonekera chifukwa chakuti kusakanikirana kwa insulin kumafooka. Poyamba, izi zimathetsedwa ndikuwonjezereka kwa pancreatic insulin. Mu magawo amtsogolo a matendawa, mafuta ochulukirapo amapezeka mu glycerin ndi mafuta achilengedwe aulere. Koma nthawi imeneyi, kuchepa thupi sikumabweretsa chisangalalo chochuluka.

Glycerin ndi mafuta aulere acids amalowa m'chiwindi, pomwe lipoproteins yotsika kwambiri imapangidwa kuchokera kwa iwo. Izi ndizinthu zoyipa zomwe zimayikidwa pamakoma amitsempha yamagazi, ndipo atherosclerosis ikupita patsogolo. Kuchuluka kwa glucose, komwe kumawoneka chifukwa cha glycogenolysis ndi gluconeogeneis, kumalowanso m'magazi kuchokera pachiwindi.

Zizindikiro za kagayidwe kachakudya mwa anthu zimatengera chitukuko cha matenda ashuga. Chifukwa kukana insulini kwazaka zambiri kwabwezedwa ndi kuchuluka kwa insulin ndi maselo a beta a kapamba. Zikatero, kuchuluka kwa insulin m'magazi kumawonedwa - hyperinsulinemia.

Hyperinsulinemia yokhala ndi shuga m'magazi ndi chizindikiro cha insulin komanso harbinger wa chitukuko cha matenda ashuga a mtundu 2. Popita nthawi, maselo a beta a kapamba amasiya kulimbana ndi katundu, yemwe amakhala wokwera kangapo kuposa masiku onse. Amatulutsa insulini yocheperako komanso yocheperako, wodwala amakhala ndi shuga wambiri komanso matenda ashuga.

Choyamba, gawo loyamba la insulin secretion limavutika, i.e, kutulutsa kwa insulin mwachangu m'magazi poyankha katundu. Ndipo basal (maziko) obisika wa insulin amakhalanso ochulukirapo. Mwazi wa magazi ukakwera, umakulanso minofu ya insulin komanso umalepheretsa kugwira ntchito kwa maselo a beta mu secretion ya insulin. Njira imeneyi yopezera matenda a shuga imatchedwa "glucose toxicity."

Zoopsa pamtima

Amadziwika kuti odwala omwe ali ndi matenda a shuga a 2, kufa kwa mtima kumachulukanso katatu, poyerekeza ndi anthu omwe alibe zovuta za metabolic. Tsopano asayansi ndi akatswiri ochulukirachulukira akukhulupirira kuti kukana insulini ndipo palimodzi, hyperinsulinemia ndi chiopsezo chachikulu cha matenda a mtima ndi sitiroko. Komanso, izi sizitengera kuti wodwalayo wayamba kudwala matenda a shuga kapena ayi.

Kuyambira m'ma 1980s, kafukufuku wasonyeza kuti insulini imakhudza mwachindunji makoma a mitsempha yamagazi. Izi zikutanthauza kuti ma atherosselotic plaque ndi kuchepetsedwa kwa lumen ya ziwiya kumayenda mothandizidwa ndi insulin m'magazi omwe amayenda kudzera mwa iwo.

Insulin imayambitsa kuchuluka ndi kusunthika kwa maselo a minofu yosalala, kapangidwe ka lipids mkati mwake, kuchuluka kwa ma fibroblasts, kutseguka kwa dongosolo la magazi, komanso kuchepa kwa ntchito ya fibrinolysis. Chifukwa chake, hyperinsulinemia (kuchuluka kwa insulin m'magazi chifukwa cha kukana insulin) ndikofunikira kwambiri pakukula kwa atherosulinosis. Izi zimachitika kale nthawi isanayambike wodwala wachiwiri.

Kafukufuku akuwonetsa kulumikizana kowonekera bwino pakati pa insulin yowonjezera komanso zinthu zomwe zimayambitsa matenda a mtima. Kutsutsa kwa insulin kumabweretsa mfundo yoti:

• kunenepa kwambiri pamimba,
• mbiri ya cholesterol yamwazi imakulirakulira, ndi zolemba zochokera ku cholesterol “yoyipa” pamakoma amitsempha yamagazi,
• Kuchepa kwa magazi m'mitsempha kumawonjezeka,
• Khoma la chotupa cha carotid limakhala lokwera (kuunika kwa mitsempha)

Ubale wolimba uwu udatsimikizika onse mwa odwala matenda a shuga a 2 komanso mwa anthu ena popanda iwo.

Njira yothandiza pochizira matenda a shuga kuyambira magawo 2 a matenda ashuga a 2, komanso bwino asanayambe, ndi m'zakudya. Kunena zowona, iyi si njira yothandizira, koma kokha kuwongolera, kubwezeretsa bwino pang'onopang'ono ngati metabolism yovunda. Zakudya zamagalimoto ochepa omwe amakhala ndi insulin kukana - ziyenera kutsatira.

Pakatha masiku 3-4 kusintha kwa chakudya chatsopano, anthu ambiri amawona kusintha kwaumoyo wawo. Pambuyo pa masabata 6-8, mayeso amawonetsa kuti cholesterol "yabwino" m'magazi imakwera ndipo yoyipa "imagwa." Mlingo wa triglycerides m'magazi umatsika kukhala wabwinobwino. Komanso, izi zimachitika patatha masiku 3-4, ndipo mayeso a cholesterol amasintha pambuyo pake. Chifukwa chake, chiopsezo cha atherosulinosis chimachepetsedwa kangapo.

Maphikidwe a chakudya chamafuta ochepa motsutsana ndi insulin

Palibe njira zenizeni zochizira insulin. Akatswiri odziwa ntchito zamtundu wa majini ndi biology akugwira ntchito pamenepa. Mutha kuthana ndi vutoli mwakutsatira zakudya zamagulu ochepa. Choyamba, muyenera kusiya kudya zakudya zamafuta, ndiko kuti, shuga, maswiti ndi zinthu zoyera za ufa.

Mankhwalawa amapereka zotsatira zabwino. Gwiritsani ntchito kuwonjezera pakudya, osati m'malo mwake, ndipo lankhulanani ndi dokotala wanu kaye za mapiritsi. Tsiku lililonse timatsata nkhani pochiza insulin. Ma genetics amakono ndi microbiology zimagwira zozizwitsa zenizeni. Ndipo tikuyembekeza kuti m'zaka zikubwerazi azitha kuthetsa vutoli pamapeto pake. Ngati mukufuna kudziwa kaye, lembani zomwe timalemba, ndi zaulere.

Funso: Palibe mfundo yosadziwika bwino m'buku la UD2, Lyle amalankhula zochepetsa thupi komanso kuti kukana insulini kungakhale kothandiza pankhaniyi. Kodi mungandifotokozere malingaliro anu pankhaniyi, chifukwa ndimadokotala wazakudya ndipo ndakhala ndikuganiza ndikuwerenga kuti sizothandiza. Ndimachita chidwi ndi malingaliro atsopano.

Yankho: Izi ndizosemphana ndi malingaliro wamba ndipo sizimagwirizana ndi zomwe anthu ambiri amakhulupirira (ndizovuta kwambiri kuposa zomwe zalembedwa m'mabuku anga kapena pamwambapa). Monga mwachizolowezi, ndikufunika ndikuuzeni.

Momwe mahomoni amagwirira ntchito

Hormoni ndi chinthu chilichonse m'thupi chomwe chimayambitsa china kwina (kusainira mankhwala opangidwa ndi ma cell a thupi ndikukhudza maselo a mbali zina za thupi). Mwaukadaulo, mutha kusiyanitsa ma neurotransmitters (omwe amagwira ntchito kwanuko) ndi mahomoni (omwe amagwira ntchito kwina kapena m'thupi lonse), koma izi ndizambiri zopanda tanthauzo. Chifukwa chake mahomoni amamasulidwa kuchokera ku chiwalo chilichonse kapena minofu ya thupi (mwachitsanzo, chithokomiro kuchokera ku chithokomiro cha chithokomiro, insulini kuchokera ku kapamba), kwinakwake chimamangiriza ku receptor ndipo imakhala ndikuwongolera.

Loko ndi chifungulo ndi fanizo pafupifupi lonse kufotokozera momwe mahomoni amagwirira ntchito. Hormoni ndiye fungulo, ndipo cholandirira chake chokhoma ndicho loko. Chifukwa chake, kiyi imayikidwa mu loko ndi mphamvu yoyendetsera imayikidwa.Hormoni iliyonse imakhala ndi cholandilira chake (monga fungulo limakwanira kukiya), koma pakhoza kukhala china chake chotchedwa mtanda-reactivity, pomwe mtundu wina wa mahomoni umalowa mu mahomoni ena. Palibe chifukwa chodandaulira ndi izi.

Chifukwa chake, insulin ili ndi insulin receptor. Insulin ikamangirira ku cholandilira ichi, zowunikira zimachitika (zomwe zikufotokozedwa pano). Ndipo ma cell a insulin amenewa amapezeka mthupi lonse, muubongo, m'misempha yotupa, m'chiwindi, komanso m'maselo a mafuta. Zitatu zomaliza ndi mfundo zazikulu zomwe muyenera kuda nkhawa.

Tsopano, zinthu zingapo zimazindikira momwe mahomoni amagwirira ntchito bwino (ndiko kuti, kukula kwamalamulo kumachitika). Zitatu zazikuluzo ndi kuchuluka kwa timadzi timeneti (mwanjira ina yambiri, izi zikutanthauza kuti zotsatira zazikulu), momwe receptor imakhudzira (momwe imakhudzira ndi mahomoni), ndi zomwe zimatchedwa kuti ubale. Osadandaula ndi izi, ndikuphatikizanso gawo lachitatu lalikulu pakukwanira kwathunthu.

Chifukwa chake, ngati pali mahomoni ambiri m'thupi, ndiye kuti amatumiza mameseji ochulukirapo kuposa momwe amakhala ochepa, ndipo mosemphanitsa. Testosterone yochulukirapo, mwachitsanzo, imanga minofu yambiri kuposa zochepa. Koma izi sizowona nthawi zonse, ndipo ndi pomwe pomwe chidwi cha receptor (kapena kukana) chimayamba kusewera. Izi zikuwonetsa momwe wolandirayo amayankhira bwino kapena momwe timavomera. Chifukwa chake, ngati cholandilira chimagwira mtima, ndiye kuti mahomoni ochepa amakhala ndi phindu lalikulu. Ngati receptor imalephera, ndiye kuti kuchuluka kwakukulu kwa mahomoni sikungakhale ndi vuto.

Chidziwitso: Mwaukadaulo, pakhoza kukhala china chake chotchedwa receptor dzanzi ndi kukana, zomwe ndi zinthu zosiyana pang'ono, koma, kwenikweni, zilibe kanthu apa. Umu ndi momwe mahomoni amagwirira ntchito. Mutu wotsatira.

Kodi insulin imatani?

Pali malingaliro opusa ambiri onena za insulin yoyandama mozungulira (likukhalira, kodi mahomoni amayandama?), Koma taganizirani za insulin kokha ngati kusokonekera kwa mahomoni. Akutulutsidwa poyankha kudya zama protein ndi mapuloteni (koma osayankhira mafuta, omwe angayambitse kukana kwa insulin mwanjira zina), insulin imayika thupi m'njira yosungira mphamvu. Koma musaganize kuti izi zikutanthauza kuti mafuta azakudya sangakupatseni mafuta.

Mu minofu ya mafupa, insulini imalimbikitsa kusungirako ndi / kapena kuwotcha mafuta zamafuta. Mu chiwindi, imasiya kupanga shuga. M'maselo amafuta, amathandizira kudzikundikira kwa ma calories ndikulepheretsa kumasulidwa kwa mafuta (amalepheretsa lipolysis). Apa ndipomwe insulin idakhala ndi mbiri yoyipa.

Eya, insulin ndilimodzi mwazizindikiro mu ubongo zomwe zimayenera kuchepetsa njala, ngakhale kuti sizikuyenda bwino. Palinso umboni kuti abambo amayankha kwambiri insulin kuposa azimayi (omwe amayankha kwambiri leptin). Nawonso azimayi amakhala ndi nkhawa kwambiri kuposa amuna.

Kodi kukana insulin ndi chiyani?

Kwenikweni, ndikutanthauza zotsatira za kukaniza kwa thupi. Kukokana kwa minofu ya mafupa kumatanthauza kuti insulini silingasungitse michere monga glycogen kapena kuyambitsa kuyaka kwa glucose. Mu chiwindi, kukana insulini kumatanthauza kuti kuchuluka kwa insulini sikungalepheretse mpweya wa okosijeni mu chiwindi. Kukana kwa insulini muubongo kumatanthauza kuti insulin siyigwira ntchito yake yochepetsa njala.

Koma khungu la mafuta likakhala kuti limalephera kukhala ndi insulini, izi zikutanthauza kuti insulini sizingopeza kokha ma calorie, komanso sangathe kuletsa kumasulidwa kwamafuta acid. Werengani chiganizo ichi mpaka chitamveka bwino, ichi ndiye chifungulo cha funso.

Komanso, thupi likayamba kukhala losagwirizana ndi insulin, ndipo insulini imagwira ntchito kwambiri, thupi limafunafuna kuti litulutse insulin yambiri kuti ilipire.Ichi ndi truism (wodziwika bwino) m'thupi, ngati cholandirira sichitha, ndiye kuti thupi limatulutsa zochulukirapo, kuyesera kudzikakamiza yokha kuti igwire bwino ntchito. Koma izi sizigwira ntchito nthawi zonse. Kuphatikiza apo, kuchuluka kwambiri kwa mahomoni nthawi zambiri kumayambitsa kukana kwa receptor. Chifukwa chake, imakhala yoyenda mozungulira.

Kodi chimayambitsa kukana insulini ndi chiyani?

Zinthu zambiri. Zachidziwikire, genetics, ndizosewerera kwambiri, koma sitingathe kuzilamulira, motero timanyalanyaza. Kusagwiritsa ntchito kumachepetsa mphamvu ya insulin, ndipo kuchita pafupipafupi kumawonjezera (sindidzapita pazifukwa). Selo ikadzazidwa ndi michere, mwachitsanzo, minofu ikadzaza ndi glycogen kapena intramuscular triglyceride (IMTG ndiye mtundu wamafuta womwe umasungidwa m'misempha yamafupa) umayamba kugonjera insulini. Ganizirani ngati thanki yathunthu yamagesi, kuyesa kubayira mafuta ambiri mkati mwake kudzapangitsa kusefukira, chifukwa kulibe malo.

Zakudya zimakhudza kukana, mwachitsanzo, kudya kwambiri zamafuta ndi mafuta, zimayambitsa kukana kwa insulin. Pakapita nthawi, kudya kwamafuta ambiri kungasinthe kapangidwe ka membala wa cell, komwe kumayambitsa mavuto. Fructose wambiri (mawu osakwanira) angayambitse kukana kwa insulin.

Ndanena pamwambapa kuti kuchuluka kwambiri kwa mahomoni kungapangitse kukana kwa receptor. Chifukwa chake, ngati wina alibe ntchito, adya chakudya chamafuta ambiri, mafuta, ndi ena, amakhala ndi insulini yambiri ndipo izi zimayambitsa kukana. Umu ndi momwe anthu ambiri amakono amakhalira.

Kunenepa kwambiri m'thupi kumakhudzanso insulin. Izi sizachilengedwe ayi, mungapeze anthu osakhazikika omwe ali ndi insulin yolephera komanso anthu ochulukirapo omwe amakonda chidwi ndi insulin. Koma pali kuphatikiza kwabwino kwambiri.

Muyeneranso kumvetsetsa chinthu china chofunikira kwambiri chakuti thupi pang'onopang'ono limayamba kugonjetsedwa ndi insulin. Minofu yofupa (kapena mwina ndiye chiwindi, sindingakumbukire) imayamba kugonjetsedwa, ndiye kuti chiwindi (kapena minofu ya mafupa, ngati chiwindi ndi choyamba). Izi zimabweretsa kuti thupi silingaletse kupanga shuga m'chiwindi (chifukwa chake, zomwe zimakhala m'magazi zimangokhala zamphamvu nthawi zonse). Ndipo pamapeto pake, maselo amafuta amakhala insulin.

Izi zikachitika, zomwe mungawone ndizakuti magazi ali ndi mafuta ambiri acid (hypertriglyceridemia), cholesterol yambiri, glucose wambiri, ndi zina zambiri, zakudya zomwe zikubwera zilibe kumene zingapite. Sitha kusungidwa m'matumba, sangathe kusungidwa mu chiwindi, sungasungidwe mu maselo amafuta. Izi zimayambitsa gulu la mavuto ena.

Zotsatira za insulin kukana mafuta.

Zomwe, pamapeto, zimandibweretsa ku nkhani yayikulu. Anthu ambiri amakhulupirira kuti kukana insulini kumapangitsa kuti mafuta azikwana, pomwe ine ndimanena kuti zimathandiza pakuchepa kwamafuta. Zonsezi, ndi zina - chowonadi. Anthu ena makamaka amatulutsa insulin yambiri chifukwa cha chakudya. Ngati muphatikiza izi ndi ma genulin kapena moyo wokhudzana ndi insulin, minyewa singasungike m'mitsempha, koma imapita kumaselo a mafuta (komwe insulin ikhoza kugwirabe ntchito). Inde, kukana insulini kumayambitsa kunenepa kwambiri.

Koma taganizirani zomwe zimachitika thupi likagonjetsedwa ndi insulin kwathunthu. Kapena zochitika za m'maganizo momwe mungapangire maselo amafuta osagwirizana ndi insulin. Tsopano insulin sangadziunjike ma calories m'magazi amafuta ndipo sangathe kupondereza kukhathamiritsa kwamafuta. Pankhani ya kuchepa kwamafuta, izi ziyenera kukhala zabwino. Ngati simungasunge mafuta m'maselo amafuta mukamadya ndipo ndikosavuta kupeza mafuta achilendo, zikutanthauza kuti mafuta amasavuta kutayika.

Zikuwoneka kuti thupi likuyesera kukankhira mafuta kutali ndi ma cell amafuta (omwe amakhalanso odzaza) kuti aletse kuchuluka kwamafuta amthupi. Ndipo ndizomwe amayesa kuchita. Pali matani ambiri osinthika pomwe anthu amayamba kunenepa, zomwe zimayenera kupewa mafuta ochulukirapo, ndipo kukana ndi chimodzi mwazomwezo. Kusintha kumeneku sikugwira ntchito bwino.

Ndipo onani ena mwa mfundo zotsatirazi. Pali kalasi ya mankhwala omwe amatchedwa thiazolidinedione kapena glitazones omwe nthawi zambiri amagwiritsidwa ntchito pokonza insulin sensitivity mu kunenepa kwambiri kapena metabolic syndrome. Mafuta okwera kwambiri omwe amapezeka m'magazi ndi mafuta achilengedwe amawononga thupi, ndipo madokotala amafuna kuwachotsa. Koma mankhwalawa amagwira ntchito mwakuwonjezera chidwi cha insulin m'maselo a mafuta. Ndipo mafuta ayamba kukula.

Palinso umboni wina (koma osati onse) kuti insulin sensitivity imalosera kulemera ndi kuchepa kwamafuta ndi insulin kukana. Izi zikufotokozanso chifukwa chake zosagwirizana ndi insulin, koma anthu owonda amakana kulemera, musangosunga ma calories m'maselo amafuta.

Ganizirani nthawi yosavuta yochepetsera kunenepa ndi kutha kwa zakudya zanu mukakhala kuti insulini ikukhudzidwa kwambiri. Ndipo nthawi yosavuta kwambiri yochepetsera mafuta ndi pamene wina ali ndi mafuta ambiri mthupi, ndipo nthawi zambiri amakhala osagwirizana ndi insulin. Ndikuganiza kuti mumvetsetsa.

Onani kuti mukayamba kuphunzitsidwa ndi kunenepa kwambiri, makamaka kuphunzitsa kuchepa thupi (komwe kumatsitsa minofu ya m'mimba ndikulimbikitsa minofu kumverera kwa insulin), makamaka ngati amachepetsa chakudya, amawoneka kuti amatha kuona zodabwitsazi kuchepa kwamafuta ndikupeza mphamvu.

Ganizirani zamitundu iwiri yamphamvu kwambiri yotsitsa mafuta, Clenbuterol ndi Kukula Hormone, yomwe imayambitsa kukana kwa insulin. Koma anthu akaphunzitsa zolimbitsa thupi, kuchepa mphamvu kwa insulin kumapitilira. Minofu imatenga ma calorie omwe sungasungidwe kwina m'thupi (nthawi yambiri).

Zili ngati kuti mu ma calories a thupi amasamutsidwa kuchokera ku maselo amafuta kupita ku minofu. Ndipo ndikuganiza izi ndizomwe zikuchitika. Ntchito, glycogen depletion imawonjezera mphamvu ya minofu yamatumbo kuti insulin. Malingana ngati maselo amafuta amakhalabe osagwirizana ndi insulin, ma calories amapita ku minofu ndikusiya mafuta.

Chowonadi ndi kukana insulini.

Tsoka ilo, kupatula vuto limodzi lokhala ndi kunenepa kwambiri (kapena mukamagwiritsa ntchito mankhwala osokoneza bongo), kukana insulini kumatha kusintha mbali inayo yomwe imayamba. Anthu akamataya mafuta, maselo amafuta amayamba kukhudzana kwambiri ndi insulin (ichi ndi gawo lina chifukwa chake zimakhala zovuta kwambiri kusamutsa mafuta ochulukirapo), ndiye kuti chiwindi (kapena minofu), kenako minofu (kapena chiwindi).

Zachidziwikire, maphunziro amatha kusintha izi. Izi, zowona, ndi chinthu chokhacho champhamvu kwambiri chomwe tingagwiritse ntchito kukonza mphamvu ya insulin. Ndipo mpaka maselo amafuta atayamba kukhala ndi insulin (kachiwiri, amatani, mafuta amayamba bwanji kuchepa), mutha kupeza mphamvu kuchokera kumaselo amafuta kupita ku minofu ya mafupa.

Ndipo, mwachiyembekezo, ili ndi yankho la zomwe zidanenedwa mu Ultimate Diet 2.0.

Mafuta a soya ndi mafuta ophikira masamba ndipo kutchuka kwake kukukula padziko lonse lapansi. Koma olemera mu mafuta osakwaniritsidwa, makamaka linoleic acid, mafuta a soya amayambitsa kunenepa kwambiri, matenda a shuga, insulin kukana, komanso matenda osokoneza bongo a mafuta aimpso mu mbewa.

Zipangizo ndi njira zakufufuzira

Ofufuza ku Yunivesite ya California ku Riverside anayesa mafuta a soya osintha ma genetically (GMO), otulutsidwa ndi DuPont mu 2014.Ili ndi mulingo wochepa wa linoleic acid, chifukwa chomwe mafuta ofanana ndi mafuta a azitona ndiye maziko azakudya za ku Mediterranean ndipo amaonedwa kuti ndi athanzi. Ofufuzawo anayerekezera mafuta amtundu wa soya ndi mafuta a kokonati okhala ndi mafuta achilengedwe ambiri ndi mafuta a soya a GMO.

Zotsatira za ntchito yasayansi

"Tapeza kuti mafuta onse atatu amakweza cholesterol m'chiwindi ndi magazi, ndikupereka nthano yotchuka yomwe mafuta a soya amatsitsa cholesterol yamagazi," adatero Frances Sladek.

"Poyeserera kwathu, mafuta a azitona amayambitsa kunenepa kwambiri kuposa mafuta a kokonati, ngakhale ali ochepera kuposa mafuta amkati a soya, zomwe zinali zodabwitsa chifukwa mafuta a azitona amawona kuti ndiabwino kwambiri kuposa mafuta onse azipatso," adatero Poonamjot Deol. Zina mwa zoyipa zoyipa zamafuta amnyama zitha kupezeka chifukwa cha kuchuluka kwa asidi wa asidi, chifukwa nyama zambiri za pafamu zimadyetsedwa ufa wa soya. Ichi ndichifukwa chake zakudya zamafuta ambiri zomwe zimakhala ndi mafuta amkaka a soya zimafanana ndi chakudya chamafuta.

Ofufuzawo akukhulupirira kuti kuchuluka kwa mafuta a soya kungakhale gawo lomwe likuthandizira kunenepa kwambiri. Malinga ndi Centers for Disease Control and Prevention, 35% ya akuluakulu ndi onenepa kwambiri chifukwa cha matenda ashuga, matenda a mtima komanso khansa.

"Zomwe tapeza sizikugwirizana ndi zinthu zina za soya, monga msuzi wa soya, tofu ndi mkaka wa soya," adatero Sladek. "Kafukufuku wambiri akufunika pa kuchuluka kwa mankhwala a linoleic acid pazinthu zina ndi zina."

Linoleic acid ndi mafuta acofunikira. Anthu onse ndi nyama ayenera kulandira kuchokera ku zakudya zawo. "Koma izi sizitanthauza kuti ndikofunikira kukhala ndi zochulukirapo m'zakudya zathu," adatero Deol. "Thupi lathu limangofunika asidi wambiri 1-2%, koma anthu ena amapeza asidi 8-10%."

Ofufuzawo amalimbikitsa kudya mafuta ochepa a soya wamba. Sladek anati: “Ndinkangogwiritsa ntchito mafuta a maolivi okha, koma tsopano ndawaikamo mafuta a kokonati. Mwa mafuta onse omwe tidayesa pakali pano, mafuta a kokonati ali ndi zotsatira zoyipa zochepa za metabolic, ngakhale zimakhala ndi mafuta pafupifupi onse. Mafuta a kokonati amayambitsa mafuta m'thupi, koma ochulukirapo kuposa mafuta a soya wamba. ”

Deol, Poonamjot, et al. "Omega-6 ndi omega-3 oxylipin amathandizira kunenepa kwambiri kwa mafuta a soya mu mbewa." Sayansi inasimba 7.1 (2017): 12488.

Kufunika kwa insulin mu kagayidwe kachakudya ka thupi la munthu nkovuta kwambiri kudya. Chimachitika ndi chiyani ndi kukana insulini? Chifukwa chiyani zimawonekera ndipo zingakhale bwanji zowopsa? Werengani zambiri za izi, komanso kuphwanya mphamvu ya insulin pazinthu zosiyanasiyana komanso za mankhwalawa.

Kodi kukana insulin ndi chiyani?

Kukana insulini ndikuphwanya kwa kagayidwe kachakudya poyankha zochita za insulin. Umu ndi momwe ma cell omwe amakhala ndi mafuta ambiri, minofu ndi chiwindi amasiya kuyankha zotsatira za insulin. Thupi limapitiliza insulin synthesis mwachangu, koma siligwiritsidwa ntchito moyenera.

Mawuwa amagwira ntchito pa kuthana ndi mapuloteni, lipids ndi zochitika zina zam'mimba. Izi zitha kukhudza dongosolo lililonse la metabolic, kapena onse nthawi imodzi. Pafupifupi matenda onse azachipatala, kukana insulini sikuzindikirika mpaka kuwonekera kwa ma metabolism mu metabolism.

Zakudya zonse mthupi (mafuta, mapuloteni, chakudya) monga malo osungirako mphamvu zimagwiritsidwa ntchito masana tsiku lonse. Izi zimachitika chifukwa cha zochita za insulin, popeza minofu iliyonse imayimilira mosiyanasiyana. Makinawa amatha kugwira ntchito moyenera kapena ayi.

Mtundu woyamba, thupi limagwiritsa ntchito chakudya ndi mafuta popanga mamolekyulu a ATP. Njira yachiwiri imadziwika ndi kukopa kwa mapuloteni pazolinga zomwezo, chifukwa chomwe zotsatira za anabolic zama glucose zimachepa.

1. Kulenga kwa ATP,
2. shuga insulin kwenikweni.

Pali kulekanitsidwa kwa njira zonse za metabolic komanso kuyambitsa zovuta zamagulu.

Zifukwa zachitukuko

Asayansi sangatchulepo zifukwa zenizeni zomwe zimapangitsa munthu kuyamba kulimbana ndi insulin. Ndizodziwikiratu kuti imawonekera mwa omwe amakhala ndi moyo wongokhala, wonenepa kwambiri, kapena wongobadwa nawo. Zomwe zimayambitsa izi zitha kukhalanso njira zamankhwala osokoneza bongo ndi mankhwala ena.

Zizindikiro zakuchitika

Kuchepa kwa insulin kukhudzika kumatha kuphatikizidwa ndi zizindikiro zina. Komabe, ndizovuta kuzindikira izi zokha mwa iwo.

Zizindikiro za insulin kukana sizili zachindunji ndipo zitha kuyambitsidwa ndi matenda ena.

Ndi kukana insulin mwa munthu, zizindikiro zotsatirazi zimawonekera:

Kunenepa kwambiri ndi Insulin Resistance

Kunenepa kwambiri ndi imodzi mwazinthu zazikulu zotsogola. Kuti mudziwe zoyenera kudziwa zamkati mwa insulin komanso metabolic syndrome, muyenera kudziwa cholozera chanu. Nambalayi imathandizanso kuzindikira gawo la kunenepa kwambiri komanso kuwerengera zoopsa zomwe zingayambitse matenda a mtima.

Mlozo umaganiziridwa molingana ndi mawonekedwe: Ine = m / h2, m ndiye kulemera kwanu m'makilogalamu, h ndi kutalika kwanu mu mita.

Mndandanda wamkulu wazakudya mu kg / m²

Chiwopsezo cha kukana insulini
ndi matenda ena

Kodi insulin kukana (IR)

Mawu akuti insulin kukana (IR) ali ndi mawu awiri - insulin ndi kukana, i.e. insulin insensitivity. Kwa anthu ambiri sizikudziwika bwino kuti liwu loti "insulin kukana", komanso tanthauzo la mawuwa, kuopsa kwake ndi zomwe zikufunika kuchitidwa kuti apewe. Chifukwa chake, ndidaganiza zotsogolera pulogalamu yaying'ono ndikukuwuzani zala zanga zokhudzana ndi izi.

M'nkhani yanga, ndidalankhula za zomwe zimayambitsa matenda ashuga, ndipo pakati pawo panali kukana insulini. Ndikupangira kuti muwerenge, ndizofotokozedwa kwambiri.

Monga momwe mumaganizira, insulini imakhudza pafupifupi minofu yonse ya mthupi, chifukwa glucose monga mafuta opangira mphamvu ndi yofunika mu khungu lililonse la thupi. Pali, mwachidziwikire, zimakhala zina zomwe zimapanga shuga m'magazi popanda inulin, monga ma cell a ubongo ndi ma lens amaso. Koma kwenikweni ziwalo zonse zimafunikira insulin kuti izitenga shuga.

Mawu akuti kukana insulin amatanthauza kulephera kwa insulin kugwiritsa ntchito shuga, mwachitsanzo, kuchepa kwake kwa shuga kumachepetsedwa. Koma insulin ilinso ndi ntchito zina zomwe sizigwirizana ndi kagayidwe ka glucose, koma zimayang'anira zochita zina za metabolic. Izi ndi monga:

• mafuta ndi mapuloteni kagayidwe
• malamulo a kukula kwa minofu ndi njira yosiyanitsira mitundu
• kutenga nawo gawo kapangidwe ka mankhwala a DNA ndi majini

Ichi ndichifukwa chake lingaliro lamakono la IR silimachepetsedwa kukhala magawo okhala ndi metabolism, koma limaphatikizanso kusintha kwa kagayidwe ka mapuloteni, mafuta, ntchito ya maselo a endothelial, mafotokozedwe a jini, ndi zina zambiri.

Kodi insulin kukana matenda?

Pamodzi ndi lingaliro la "insulin kukana" pali lingaliro la "insulin kukana syndrome." Dzina lachiwiri ndi metabolic syndrome. Zimaphatikizana ndi kuphwanya mitundu yonse ya kagayidwe, kunenepa kwambiri, matenda ashuga, matenda oopsa, kuwonjezereka kwa chiwopsezo, chiopsezo chachikulu cha atherosulinosis ndi matenda a mtima).

Ndipo kukana insulini kumathandizira kwambiri pakukulitsa komanso kupitiriza kwa matendawa. Sindingangoganiza za metabolic syndrome, chifukwa ndikukonzekera nkhani pamutuwu. Chifukwa chake, ndikukulangizani kuti musaphonye.

Zimayambitsa minofu kukana insulin

Insulin insensitivity si nthawi zonse matenda. Mwachitsanzo, pakati pathupi, usiku, nthawi yakutha msambo, kukana kwa insulin kumawonekera ana. Mwa akazi, kukhudzana ndi thupi kwa insulin kumakhalapo gawo lachiwiri la msambo.

Matenda a metabolic metabolic amapezeka nthawi zambiri zotsatirazi:

• Type 2 shuga.
• Kubwezeredwa kwa matenda a shuga 1.
• Matenda a shuga ketoacidosis.
• Matenda operewera kwambiri.
• Mowa

Kukana kwa insulini kumatha kukhalanso mwa anthu opanda matenda a shuga. Ndizodabwitsa kuti insulin insensitivity imatha kuwonekera mwa munthu wopanda kunenepa kwambiri, izi zimachitika mwa 25% ya milandu. Kwenikweni, ndithudi, kunenepa kwambiri ndi mnzake wokhudzana ndi insulin.

Kuphatikiza pa matenda ashuga, matendawa amatenga matenda a endocrine monga:

1. Thirotooticosis.
2. Hypothyroidism
3. Itsenko-Cushing's syndrome.
4. Acromegaly.
5. Pheochromocytoma.
6. PCOS (polycystic ovary syndrome) ndi kusabereka.

Pafupipafupi IR

• Mu matenda a shuga - mu 83.9% ya milandu.
• Ndi kulolerana kwa glucose - mu 65.9% ya milandu.
• Ndi matenda oopsa - mu 58% ya milandu.
• Ndi kuwonjezeka kwa cholesterol, mu 53,5% ya milandu.
• Ndi kuwonjezeka kwa triglycerides, mu 84.2% ya milandu.
• Ndi kuchepa kwa milingo ya lipoproteins yapamwamba (HDL) - mu 88.1% ya milandu.
• Ndi kuwonjezeka kwa uric acid wambiri - mu 62,8% ya milandu.

Monga lamulo, kukana insulini kumakhala kosadziwika mpaka kusintha kwa metabolic m'thupi kumayamba. Chifukwa chiyani zotsatira za insulin m'thupi zimasokonezeka? Njirayi idaphunziridwabe. Izi ndi zomwe tsopano zikudziwika. Pali njira zingapo zomwe zimatulutsa dzanzi, zomwe zimagwira pamagulu osiyanasiyana a insulin.

1. Pakakhala insulin yachilendo, ndiye kuti kapamba imabisala kale ndi insulin, yomwe singathe kupereka bwinobwino.
2. Pakakhala zachilendo kapena kuchepa kwa chiwerengero cha insulin zolandilira minofu yomwe.
3. Pakakhala zovuta zina zomwe zimachitika m'selo yomweyi pambuyo pakuphatikizana kwa insulin ndi receptor (vuto la postreceptor).

Ma Anomalies a insulin ndi ma receptor ndi osowa kwambiri, malinga ndi olemba, makamaka kukana kwa insulin kumachitika chifukwa cha zovuta za postreceptor za kufalitsa kwa insulin. Muyenera kuti mukudandaula zomwe zingakhudze pulogalamuyi, ndizinthu ziti zomwe zimawalimbikitsa.

Pansipa ndalemba zinthu zofunika kwambiri zomwe zingayambitse zovuta za pambuyo pa receptor:

• M'badwo.
• Kusuta.
• Zochita zolimbitsa thupi.
• Zakudya zopatsa thanzi
• Kunenepa kwambiri, makamaka m'mimba.
• Chithandizo cha corticosteroids, beta-blockers, nicotinic acid, etc.

Chifukwa chiyani kukana kwa matenda a shuga a 2

Malingaliro atsopano a insulin insensitivity development akupangidwa. Ogwira ntchito ku Tula State University, motsogozedwa ndi Myakisheva Raushan, amaika lingaliro molingana ndi momwe kukana insulini kumawerengedwa ngati njira yosinthira.

Mwanjira ina, thupi limateteza maselo ku insulin yochulukirapo, kuchepetsa kuchuluka kwa zolandirira. Zonsezi zimachitika chifukwa mkati mwakakhudzidwa ndi shuga ndi khungu mothandizidwa ndi insulin, zinthu zina zimathamangira mkati, zimasefukira. Zotsatira zake, khungu limatupa ndikuphulika. Thupi silingalole kufa kwakukulu, chifukwa chake simalola kuti insulini ichite ntchito yake.

Chifukwa chake, chinthu choyamba mwa odwala chotere ndikuchepa kwa shuga chifukwa cha michere, zolimbitsa thupi ndi mankhwala omwe amachotsa kukana. Kukhazikitsa mankhwala osokoneza bongo ndi jakisoni wa insulin kumangowonjezera zomwe zikuchitika komanso kukulitsa kwa zovuta za hyperinsulinism.

Indulin Resistance Index: Momwe Mungatenge ndi Kuwerengera

Kuzindikira ndi kuwunika kwa insulin kutsutsana kumatsimikiziridwa ndi mitundu iwiri yowerengera. Mayesowa amatchedwa HOMA IR ndi CARO. Kuti muchite izi, muyenera kupereka magazi kuti muwoneke.

IR Index (HOMA IR) = IRI (μU / ml) * GPN (mmol / L) / 22.5, pomwe IRI ndi insulin yogwiritsira ntchito insulin, ndipo GPN ikufulumira plasma glucose.

Nthawi zambiri, chiwerengerochi chimachepera 2.7. Ngati ichulukitsidwa, ndiye kuti zoopsa zomwe zimatulutsidwa pamwambazi zimachuluka.

Insulin Resistance Index (CARO) = GPN (mmol / L) / IRI (μU / ml), pomwe IRI imasala kudya kwa insulin, ndipo GPN ikufulumira plasma glucose.

Nthawi zambiri, chiwerengerochi chimachepera 0,33.

Kodi chiwopsezo cha kusazindikira mtima kwa maselo ndi chiyani?

Insulin insensitivity mosakayika imabweretsa kuchuluka kwa insulin m'magazi - hyperinsulinism. Izi zimachitika kudzera mu mayankho osapindulitsa pomwe, chifukwa chosowa insulini, kapamba amayamba kutulutsa insulin yambiri, ndipo amatuluka m'magazi. Ngakhale pali zovuta za kutulutsa kwachilengedwe kwa glucose ndikulimbana ndi insulin, sipangakhale vuto ndi zotsatira zina za insulin.

Choyamba, zotsatira zoyipa za insulin yochulukirapo pa mtima, kapena m'malo mwake, pakukula kwa atherosclerosis, zatsimikiziridwa. Izi ndichifukwa cha machitidwe angapo. Choyamba, insulini imatha kukhudza mwachindunji mitsempha yamagazi, ndikupangitsa kuti kukhazikika kwa makoma awo ndikupangitse kuti mapangidwe a atherogenic azikhalamo.

Kachiwiri, insulini imatha kuwonjezera vasospasm ndikuletsa kupuma kwawo, komwe ndikofunikira kwambiri pazida za mtima. Chachitatu, insulini yambiri imatha kukhudza kayendedwe ka coagulation, imathandizira kupindika komanso kuletsa dongosolo la anticoagulation, chifukwa, chiopsezo cha thrombosis chikuwonjezeka.

Chifukwa chake, hyperinsulinism imatha kuyambitsa chiwonetsero choyambirira cha matenda a mtima, kuchepa kwamitsempha, kukwapula, komanso kuwonongeka kwa ziwiya zam'munsi.

Inde, anthu omwe ali ndi insulin kukana ali pachiwopsezo chachikulu chotenga matenda a shuga. Izi ndi mtundu wamalipiro opangira thupi. Poyamba thupi limapanga insulini yambiri kuti likhale ndi shuga athithithi, potero limagonjetsa kukana. Koma posachedwa mphamvuzi zikutha ndipo kapamba sangathe kutulutsa magazi okwanira kuti asungitse shuga m'magazi, chifukwa cha zomwe glucose imayamba kukula pang'onopang'ono.

Poyamba, izi zikuwonetsedwa ndikuphwanya kulekerera kwa glucose, komwe ndidalemba m'nkhani yanga, ndikukulangizani kuti muwerenge, kenako ndi zizindikiro zowoneka za matenda ashuga. Koma akanatha kupewa izi koyambirira.

Kukana kwa insulini ndi chimodzi mwazifukwa zambiri komanso zofunika kwambiri zakusokonekera kwa matenda oopsa a anthu. Chowonadi ndi chakuti insulini yambiri imatha kulimbikitsa chidwi chamanjenje, mwakutero kuwonjezera kuchuluka kwa norepinephrine m'mwazi (mkhalapakati wamphamvu kwambiri yemwe amachititsa kuphipha kwamitsempha). Chifukwa cha kuchuluka kwazinthu izi, mitsempha yamagazi imakhala yotupa ndipo kuthamanga kwa magazi kumakwera. Kuphatikiza apo, insulin imasokoneza njira yopuma ya mitsempha yamagazi.

Njira yina yowonjezera kukakamira ndiyo kusunga madzi ndi sodium yokhala ndi insulin yambiri m'magazi. Chifukwa chake, kuchuluka kwa magazi ozungulira kumawonjezeka, ndipo pambuyo pake pamafunika kuthamanga.

Musaiwale za zotsatira za hyperinsulinemia pamitsempha yamagazi. Kugwiritsa insulini kwambiri kumapangitsa kuchuluka kwa triglycerides, kuchepa kwa lipoproteins yapamwamba kwambiri (HDL - antiatherogenic lipids, i.e., kupewa atherosclerosis), kuwonjezeka pang'ono kwa otsika osalimba a lipoproteins (LDL). Njira zonsezi zimathandizira kupita patsogolo kwa mitsempha ya mitsempha, yomwe imabweretsa zotsatira zoyipa.

Mwa akazi, ndi chizolowezi kuyika chizindikiro chofanana pakati pa polycystic ovary syndrome ndi kukana insulin. Matendawa amayambitsa kuphwanya kwa ovulation, kuyambitsa kubereka, komanso kuwonjezeka kwa androgens ofooka, zomwe zimayambitsa zizindikiro za hyperandrogenism.

Zoyenera kuchita

Ngati mwawerengera nkhaniyi mpaka kumapeto, zikutanthauza kuti mukuyang'anizana ndi vutoli ndipo mukufuna kuphunzira momwe mungagonjetsere matenda amtunduwu ndikupezanso thanzi. Semina yanga yapaintaneti "Kukana insulini ndikuwopseza", yomwe idzachitike pa Seputembara 28 nthawi ya 10:00 nthawi ya Moscow, ikuthandizidwa pa nkhaniyi.

Ndilankhula za njira zochizira ndi njira zachinsinsi zomwe madokotala aku chipatalacho sakudziwa. Mudzalandira magawo antchito okonzekera chithandizo chamankhwala, omwe adzatsimikiziridwa kuti akutsogolereni. Komanso, mphatso zaperekedwa kwa inu: “KETO-zakudya” komanso njira zamagulu azakudya za endocrine ”, zomwe zimakwaniritsa zazikulu.

Onse omwe atenga nawo mbali adzapatsidwa mwayi wojambula komanso zinthu zina zowonjezera masiku 30. Chifukwa chake, ngati simungathe kutenga nawo mbali pa intaneti, mutha kuwona chilichonse chojambulira nthawi iliyonse yabwino.

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Ndi chisangalalo ndi chisamaliro, endocrinologist Lebedeva Dilyara Ilgizovna

Kukana kwa insulin kumapezeka mwa anthu omwe ali ndi matenda ashuga kapena onenepa kwambiri. Kafukufuku wambiri adawona kuti kudya bwino komanso kuchita masewera olimbitsa thupi kumatha kusintha momwe thupi lanu limayankhira ndi insulin. M'zaka zaposachedwa, chiwerengero cha anthu odwala matenda a shuga chikuwonjezeka kwambiri, motero tiyenera kuyang'anitsitsa momwe timadyera. Chakudya chopewedwa ndi insulin chimakhala ngati wodwala matenda ashuga ndipo chimakuthandizani kuti muchepe mapaundi owonjezera ndikuwongolera shuga lanu lamagazi kuti muchepetse chiopsezo chokhala ndi matenda a shuga.

Zomwe zimapangitsa kuti insulin ikane kunenepa kwambiri, makamaka mafuta ochulukirapo m'chiuno. Mwamwayi, kuchepa thupi kungathandize thupi lanu kuwongolera insulin. Mwina chifukwa cha zakudya zoyenera kuti muchepetse kapena muchepetse kukula kwa matenda ashuga.

Chepetsani chakudya

Pali kusiyana kwakukulu ngati mutenga chakudya kuchokera ku zipatso, ndiwo zamasamba, mbewu, kapena ndi mafuta kapena shuga. Ponena za ufa, ndi bwino kudya mbewu zonse. Njira zabwino ndikugwiritsa ntchito ufa wa cocoa wa 100mleme kapena almond ndi ufa wa kokonati pazotsatira zabwino.

Pewani zakumwa Zotsekemera

Mitundu yonse ya shuga imatha kuwonjezera shuga m'magazi ndikupangitsa kuti insulin iwonongeke. Koma pali magwero ena a shuga ndi zakudya zomwe zimakhala zovulaza kuposa ena. Pewani zakumwa zozizilitsa kukhosi zotsekemera ndi shuga, manyowa a chimanga, tiyi wopanda mkaka, zakumwa zamagetsi, ndi zina zomwe zimakhala ndi sucrose ndi zotsekemera zina zopanga mafuta.

M'malo momwa zakumwa zozizilitsa kukhosi, samalani ndi madzi, koloko, tiyi kapena tiyi wakuda ndi khofi. Ngati mukufunikira kuwonjezera zokometsera zina ku chakudya kapena zakumwa zanu, gwiritsani ntchito zachilengedwe monga uchi, mphodza, madeti, mapulo manyumwa kapena ma molass.

Idyani michere yambiri

Malinga ndi kafukufuku wambiri, kugwiritsa ntchito tirigu wambiri sikuvuta kukhala ndi mtundu wachiwiri wa shuga, koma anthu ayenera kuchepetsa kuchuluka kwa tirigu wonse.

Zakudya za fiber zochulukirapo monga artichoke, nandolo, mphukira za Brussels, broccoli, nyemba, flaxseed, sinamoni ndi sinamoni zimathandiza kuwongolera insulin.Izi zamasamba ndizopamwamba zambiri ndipo zimakhala ndi zopatsa mphamvu zochepa komanso zimakhala ndi zinthu zotsutsana ndi kutupa.

Muzidya zamafuta athanzi

Pewani kudya mafuta osapatsa thanzi, monga mafuta a trans ndi mafuta ambiri, omwe m'malo mwake samapangidwa menyu. Kuchulukitsa mafuta ndikofunikira kwa anthu omwe ali ndi insulin kukaniza ndi matenda ashuga chifukwa cha kuchepa kwa chakudya.

Kugwiritsa ntchito zakudya zomwe zili ndi mafuta ochulukirapo a monounsaturated kumapangitsa kuti mafuta a glycemic asamavute pomwe mafuta amaloledwa m'malo mwa chakudya. Zakudya zomwe mungagwiritse ntchito kuti muwonjezere mafuta anu athanzi ndi mafuta a maolivi, mapeyala, mtedza, ndi mbewu.

Kuphatikiza kuwonjezera mafuta osakwaniritsidwa, muyenera kuwonjezera kuchuluka kwa mafuta a omega-3, zomwe zikutanthauza kuti kudya nsomba kawiri pa sabata. Ma mackerel oyenera, nsomba, hering'i, nsomba zoyera ndi zoyera. Mafuta a Omega-3 amatha kupezeka kuchokera ku walnuts, omwe flaxseed, mbewu za hemp, ndi mazira a mazira.

Tengani mapuloteni okwanira

Kafukufukuyu adapeza kuti kuchuluka kwa mapuloteni ambiri kumathandizira kutaya mapaundi ochulukirapo. Zakudya zamapuloteni ndizofunikira kwa anthu omwe ali ndi insulin kukana, chifukwa mapuloteni salowerera ndale pazokhudza kagayidwe kazakudya ndikusunga minofu yambiri, yomwe imatha kuchepetsedwa mwa anthu omwe ali ndi kuchepa kwa insulin.

Mapuloteni monga nkhuku, nsomba, mazira, yogati, ma almond ndi ma mphodza amathandizira kuyendetsa shuga m'magazi.

Konzani chakudya

Ponena za kuwongolera kukana insulini, kuchepa thupi ndi chinthu chachikulu. Mutha kuchepa thupi potsatira malangizo omwe amachepetsa thupi kuti muchepetse vuto la insulin, komanso muyenera kuchepetsa zopatsa mphamvu. Kafukufuku akuwonetsa kuti magawo omwe akukula ndi ofunika kwambiri pakulimbikitsa kunenepa kwambiri. Idyani nthawi zambiri, koma m'magawo ang'onoang'ono ndipo musakhale ndi njala kwambiri, chifukwa zimawonjezera mwayi wodya chakudya chotsatira. Yambirani gawo laling'ono, ndipo ngati kuli kotheka, lilani, koma osadzaza mbale yanu.

Pa mbale yanu pazikhala mapuloteni, mafuta ndi masamba nthawi zonse.

Chakudya chokhala ndi insulin kukana ndizabwino pakati pa mapuloteni oyera, mafuta amoyo, zakudya zamafuta ambiri ndi mkaka wapamwamba kwambiri. Anthu omwe ali ndi vutoli ayenera kupewetsa kudya zokhomedwa, zakumwa zotsekemera, ndi zakudya zamafuta abwino.

Kukana insulini kwa thupi lanu mwina ndi vuto lalikulu kwambiri la mahomoni ndipo ndi chimodzi mwazomwe zimayambitsa kutopa kwambiri. Anthu ambiri omwe amagwiritsa ntchito zakudya zamafuta monga gwero lawo lalikulu la ma calorus amakhala ndi insulin yolimbana ndi zovuta zosiyanasiyana. Ndipo akadzakula, ndiye kuti insulini yolimbana ndi maselo awo imayamba.

Musaganize kuti ngati shuga yanu yosala kudya komanso glycated hemoglobin ndiyabwino, ndiye kuti "mulibe mavuto okana ndi insulin." Umu ndi momwe ma endocrin amatanthauzira zaka zanga zapitazo ndipo ndinalipira chifukwa cha kupusa kwawo zaka zambiri chifukwa cha insulin kukana komanso hypothyroidism. Ndikadakhala ndi ubongo wokwanira kuti ndisamamvere kwambiri ng'ombe zawo, kuti ndizingopereka insulin pamimba yopanda kanthu ndikufanizira zomwe zili ndi moyo wathanzi malinga ndi akatswiri, ndikadachiritsidwa kale. Kugwiritsa ntchito kwambiri kapena kosapatsa thanzi insulini ndi 3-4 IU / ml, pomwe 5 IU / ml ndi apamwamba ndi magulu osiyanasiyana a zovuta. Ndipo musadabwe ngati "pazifukwa zina, ma deiodinases safuna kusintha T4 yanga kukhala T3, ngakhale insulini yanga yachangu ndi 9 me / ml (2.6 - 24,9)." Mitundu iyi (2.6 - 24,9) ilibe chochita ndi thanzi ndipo zitha kuwoneka kuti kusala kwanu kwa 6 IU / ml kapena 10 IU / ml ndi "kwabwino".

Insulin ndi chimodzi mwamafuta atatu ofunika kwambiri m'thupi la munthu (limodzi ndi T3 ndi cortisol).Ntchito yake ndikuwadziwitsa maselo pamene michere ilipo m'magazi: shuga, amino acid, mafuta, micronutrients, ndi zina zambiri. Pambuyo pake, mapuloteni apadera omwe ali m'chipindacho, otchedwa glucose transmit, amayandikira kumtunda kwa cell ndikuyamba "kuyamwa" michere yonseyo m'selo. Maselo alibe maso chifukwa chake amafunika kulumikizana nthawi yanji komanso mwachangu momwe "angatenge" michere kuchokera m'magazi. Maselo amtundu wanji? - Ndi zomwe. Minyewa, hepatic, mafuta, endocrine, maselo aubongo ndi zina zotero. Kuti ikhale yosavuta, chizindikiro cha insulin ku Russia imamveka ngati: "Selo, tenga michere!". Chifukwa chake, insulin nthawi zambiri imatchedwa "mphamvu yosungirako mphamvu" kapena "mayendedwe othandizira", ngati kuti "imasamutsa" michere kupita ku cell, ngakhale palibe chilichonse chamtunduwu chimachitika mu tanthauzo lenileni la mawu, mahomoni amangotumiza mauthenga kuchokera ku selo limodzi kupita ku lina. Ndimakonda kuzitcha kuti "mphamvu yamagetsi yamagetsi", ndi T3 - mphamvu yamafuta. Ma insulin ma cell amawongolera kuchuluka kwa michere / mphamvu zomwe zimalowa mu cell, ndipo ma T3 ma sign akuwongolera kuchuluka kwa mphamvu zomwe mphamvuzi zimawotchedwa m'chipindacho. Pazifukwa izi, zizindikiro za insulin kukana ndizofanana kwambiri ndi zizindikiro za hypothyroidism. Ndipo, mwina, chifukwa chokana kwambiri ndi insulini (zolandilira sizimva bwino chizindikiro kuchokera ku insulini ndipo michere imalowa mu cell pang'onopang'ono / zochepa)) deiodinases imachepetsa kutembenuka kwa T4 mpaka T3 ndikuwonjezera kutembenuka ndikusinthanso T3. Ngati mphamvu ilowa m'selo pang'onopang'ono, ndiye kuti ndiyotentha pang'ono pang'onopang'ono, apo ayi mutha kuwotcha chilichonse ndikusiya khungu "popanda mphamvu". Ili ndi lingaliro langa chabe, ndipo sizingafanane ndi zenizeni. Koma kwa ife, chinthu chimodzi chokha ndichofunikira - kukana insulini kumabweretsa kuchepa kwa kutembenuka kwa T4 kukhala T3 ndikuwonjezereka kwa T3. Ndipo ichi ndiye chowonadi chotsimikiziridwa ndi kafukufuku, osati malingaliro anga. Insulin imapangidwa ndi maselo a pancreatic beta akafunsidwa "kuchokera kumwamba."

Zimayambitsa kukana insulini.

Mukamadya kena kalikonse, m'mimba mwanu mumaphwanya chakudya muzinthu zazing'onoting'ono: zimaphwanya zakudya zamagulu pang'ono kukhala shuga, mapuloteni amino acid. Pambuyo pake, zakudya zonse zofunikira kuchokera ku chakudya zimatengedwa m'matumbo a matumbo ndikulowa m'magazi. Patatha theka la ola mutatha kudya, kuchuluka kwa shuga m'magazi kumakwera kangapo ndipo poyankha izi, kapamba amapanga insulin, motero amalembera maselo kuti: "tengani michere." Komanso kuchuluka kwa insulin yomwe kapamba amatulutsira m'magazi kumakhala kofanana ndi kuchuluka kwa shuga m'magazi "" Kuchulukitsa 0,5 kuchuluka kwa amino acid (mapuloteni) m'magazi ". Pambuyo pake, insulin "imagawa" masukizi, ma amino acid ndi mafuta m'maselo, titero, ndiye kuti mulingo wawo m'magazi umatsika, ndipo mlingo wa insulin umatsika pambuyo pawo. Ma shuga amino acid m'magazi amachotsedwa -> insulin imachotsa -> insulin imagawa shuga amino acid m'maselo -> shuga m'magazi amino acid amatsika -> insulin imachepa. Kuzungulira konseku kumatenga maola 2.5-3, kutengera kuchuluka kwa chakudya komanso mapuloteni pakudya.

Malingana ngati ma homosapiens amadya chakudya, chomwe adachisintha ngati makina azachilengedwe zaka mamiliyoni a chisinthiko, dongosololi limagwira ntchito bwino ngati wotchi. Pomwe amadya zipatso mosapumira (momwe muli magalamu 8-12 okha a chakudya (werengani: shuga) pa magalamu 100), omwe amakhalanso ndi fiber zambiri, akumachepetsa mayamwidwe m'mimba, palibe mavuto. Mavuto amayamba pomwe timayamba kudya zakudya zamafuta ambiri (shuga) odzaza: mpunga (80 magalamu a chakudya pama gramu 100), tirigu (76 magalamu a chakudya pamagalamu 100) ndi zonse zotengedwa, oatmeal (66 magalamu a chakudya pamagalamu 100) zakumwa zotsekemera juisi (odzaza ndi shuga), msuzi ketchups, ayisikilimu, etc.Kuphatikiza pazomwe zili ndi zakudya zambiri (shuga) mu malonda awa, mndandanda wawo wa glycemic umasiyana pang'ono ndi index ya glycemic ya shuga ya patebulo. Kugwiritsa ntchito kwazinthu izi kumabweretsa kuyambitsa kwakukulu mu shuga wamagazi ndipo, motero, kumasulidwa kwakukulu kwa insulin.

Vuto lachiwiri ndilakuti masiku ano anthu akumvetsera kwa osadziwa zakudya zopatsa thanzi kwambiri ndipo amayesetsa "chakudya chochepa", chomwe chimanena kuti muyenera kudya "m'magawo ang'onoang'ono, koma nthawi zambiri", akuwonjezera kuchuluka kwa metabolic. Kutali kwenikweni, ndiye kuti kuchuluka kwa metabolic kumawonjezeka. Mosasamala kanthu kuti mumagawa chakudya chatsiku ndi tsiku mu 2 servings kapena 12. Funsoli lidaphunziridwa bwino pofufuza ndipo palinso kanema wa Boris Tsatsulin pankhaniyi. Inde, ndipo sizikudziwikiratu kuti bwanji padziko lapansi pofunika kuthamangitsa kagayidwe kokha chifukwa timagawa chakudya chathu chambiri tsiku lililonse? Mukupita kwa nthawi, zakudya zopanda pake zimapangitsa kuti insulini ndi leptin zizikhala zolimba kwambiri komanso kuti zisamayende bwino (zomwe zimayambitsa kunenepa kwambiri komanso mavuto ena ambiri) kumachepetsa kagayidwe kachakudya . Ngakhale patali pang'ono, kafukufuku akuwonetsa kuti anthu omwe amadya pang'ono (zakudya zazikulu zitatu + ziwiri) samadya kwambiri poyerekeza ndi omwe amadya katatu patsiku. Ndiosavuta kudya mosavomerezeka ngati mumadya kangapo patsiku la 5-6 patsiku kuposa momwe mumangodya katatu kokha patsiku, ngakhale m'magawo akuluakulu. Munthu amene amadya katatu tsiku lililonse amakhala atakweza ma insulin pafupifupi maola 8 patsiku, ndipo maola 16 otsalawa ndi ochepa. Munthu amene amadya kangapo patsiku amakhala akukweza insulin tsiku lonse logalamuka (Maola 16-17 patsiku), chifukwa amadya maola 2,5 kapena 2 aliwonse.

M'miyezi ndi zaka zoyambirira, shuga ndi zakudya zapamtunduwu sizingayambitse mavuto, koma posachedwa, poyankha kuchuluka kwa insulini kwambiri, ma receptors ayamba kukana. Zotsatira zake, khungu limasiya kumva bwino chizindikiro kuchokera ku insulin. Matenda okhathamiritsa kwambiri a mahomoni aliwonse omwe angapangitse kukula kwa kukhudzidwa kwa mphamvu iyi. Chifukwa chiyani izi zimachitika momveka bwino kuti palibe amene akudziwa, koma pali malingaliro osiyanasiyana. Kwa ife sizofunikira, ndikofunikira kuti chitukuko cha insulin chikhale ndi zifukwa zisanu zazikulu:

1) Mitundu yambiri ya insulini.

2) Kufanana kwamisisitimu yayikulu.

3) Ambiri mwa mafuta a visceral.

4) Zofooka: mahomoni vitamini D, magnesium, zinc, chromium kapena vanadium. Zofooka izi zimasokoneza magwiridwe antchito a insulin receptors.

5) Kuperewera kwa testosterone mwa amuna. Kuzindikira kwa maselo kuti apange insulin mwachindunji kumadalira kuchuluka kwa testosterone ndi kuchepa kwake (pansipa 600 ng / dl) zimangopanga insulin kukana.

Yoyamba imapangidwa ndi zakudya zomwe zimakhala ndi mafuta ambiri (i.e. shuga), chifukwa chakudya ndi mafuta ochepa chabe omwe amawonongeka chifukwa cha hydrochloric acid. Chachiwiri chimapangidwa ndi zakudya zopatsa thanzi.

Munthu akayamba kukana insulini ndipo khungu limalephera kumva mawu a insulini bwino, kapamba amayesetsa kuthetsa vutolo payekha, ndikupanga insulini ina. Kubweretsa chizindikirocho m'chipindacho, kapamba amachitanso chimodzimodzi monga timachita pamene wotumizirayo sanatimve koyamba - timangotchulanso mawuwo. Ngati sanamve kuchokera kwachiwiri, timabwerezanso kachitatu. Choyipa chachikulu cha kukana insulin, insulin yambiri imayenera kupangika pamimba yopanda kanthu ngakhale itatha kudya. Masewera olimbitsa thupi amatha kudziwa zambiri za insulini, insulin yocheperako iyenera kupangidwa kuti ipereke chizindikiro ku cell.Chifukwa chake, misala ya insulin yofulumira ndi chizindikiro chachindunji cha kukula kwa insulin yolandila ma receptors. Mukakhala ndi insulini yothamanga kwambiri, momwe imagwirizira kwambiri ndi ma cell ake, ndiye kuti chizindikirocho chimalowa kwambiri m'chipindacho, ndipo mochedwa komanso moyenera khungu limapatsidwa zakudya: shuga, mapuloteni, mafuta ndi micronutrients. Ndi kukula kwa insulin, ma deiodinases amayamba kusintha osachepera T4 mpaka T3 ndi zina zambiri kuti athetse T3. Ndikuganiza kuti iyi ndi makina othandiza, koma nditha kukhala olakwika mosavuta. Zilibe kanthu kwa ife. Kukana kwa insulini kumapangitsa kuti pakhale zizindikiro zake: kuchepa mphamvu, kuchepa kwa magazi, kufooka, kufooka kwaubongo, kukumbukira kosavomerezeka, kulekerera masewera olimbitsa thupi, kukodza pafupipafupi, kudzutsidwa usiku ndikulakalaka pee, kuyamwa kwamimba m'mimba (kuzungulira m'chiuno), ndi zina zambiri.

Chifukwa chake, tiyenera kuyesetsa nthawi zonse kuti tiwonetsetse kuti ma receptor amamvera insulin momwe angathere.

Mu zaka zoyambirira, ndimabakiteriya omwe amapangitsa kuti mukhale ndi vuto la insulin, koma munjira yomwe kapamba amalumikizana ndi njirayi (amapanga insulin yambiri poyankha kukana). Izi zimapangitsa kuzungulira koyipa pamene, chifukwa cha kukana insulini, kapamba amakakamizidwa kuti apange zambiri insulin kuti ifike ku maselo, omwe amachititsa kuti insulin ikulimbana ndi nthawi yayitali. Pambuyo pake imabala ngakhale zinanso insulin, kenako izi zidzatsogolera zokulirapo insulin kukana. Munthu yekhayo amene ndinamvapo za nkhaniyi ndi dokotala waku Canada Jason Fang, wolemba cholembera wa Obesity. M'zaka zoyambirira, zakudya zama carbohydrate zimasunthira munthu kutsogolo kwa insulin, ndipo pakadali pano kusintha kwamankhwala kumakhala kothandiza ngati chithandizo: kuchepa kwamphamvu kwa chakudya chamagulu m'zakudya ndikuwonjezera mafuta (china chilichonse kupatula mafuta). Chotsatira chikubwera gawo lachiwiri, pamene kapamba imapangitsa kukula kwa insulini ndipo pakadali pano kusintha kosavuta kwa chakudya sikungathandize kapena ayi, chifukwa pakadali pano kukana insulini yayikulu, ngakhale chakudya chokhala ndi index ya insulini yochepa chimakakamiza kapamba kuti apange milingo yapamwamba kwambiri ya insulin kuchokera ku izi akuyamwa quagmire kosavuta kutuluka.

Madokotala amagawika mafuta onse kukhala subcutaneous ndi visceral (omwe amaphimba ziwalo zamkati ndi ziwalo). Kuchuluka kwa mafuta osunthika sikunapangitse kusintha kwa kukana insulin. Pakufufuza kwina, mitundu 7 ya odwala matenda ashuga ndi magulu 8 opanda matenda a shuga adatengedwa ndipo liposuction idapaka mafuta 10 kg a munthu aliyense (omwe 28% yamafuta awo onse). Kusala kudya kwa insulin ndi glucose kudya Koma kuchepa kwamafuta a visceral m'maphunziro kumapangitsa kuti maselo azikhala ndi insulin komanso amachepetsa insulin. Kwa ife, zilibe tanthauzo lenileni lomwe ndi mtundu wanji wamafuta omwe umachulukitsa kukana kwa insulini: sizingatheke kukakamiza thupi kuwotcha mafuta a visceral mwachindunji, lidzawotcha onse komanso mafuta ochulukirapo (chifukwa nthawi zambiri).

4) Palinso chifukwa chachinayi chowonjezera cha kukana kwa insulin - kuchepa kwa magnesium, vitamini D, chromium ndi vanadium. Ngakhale ndichofunikira kwambiri pa zonse, ndikulimbikitsa aliyense kuti athetse zofooka za zinthuzi, ngati zilipo. Ndipo pamenepa sikuti ngakhale kukana insulini, koma kuti simungathe kugwira bwino ntchito ngati makina azachilengedwe, okhala ndi zofooka zina za zinthu, makamaka vitamini D ndi magnesium.

Kukana kwa insulin ndi matenda a shuga a 2.

Pali mitundu iwiri ya matenda ashuga: yoyamba ndi yachiwiri.Mtundu woyamba wa shuga umakhala ndi 5% yokha ya chiwerengero chonse cha anthu odwala matenda ashuga ndipo umayamba chifukwa cha kuukira kwa autoimmune pama cell a pancreatic beta, pambuyo pake amalephera kutulutsa insulin yokwanira. Matenda a shuga oterewa amakula, monga lamulo, mpaka zaka 20 motero amatchedwa mwana (wachinyamata). Mayina ena omwe amagwiritsidwa ntchito ndi autoimmune kapena insulin amadalira.
Mtundu wa 2 wa matenda ashuga (95% ya matenda onse a shuga) ndiwo gawo lomaliza la kupita patsogolo kwa zaka ndi makumi ambiri chifukwa chokana insulini ndipo chifukwa chake amatchedwa "insulin anti." Zimapezeka ngati kukana kwa maselo a khungu lanu sikungokhala kochititsa manyazi, komanso koopsa kwambiri kotero kuti ngakhale kufutukula shuga wambiri (osagawika maselo) kudzera mu impso ndi mkodzo, thupi limalephera kukhazikika kwa glucose m'magazi. Ndipo mumawona glucose wambiri kapena glycated hemoglobin ndipo amakunena kuti tsopano ndinu mtundu 2 wodwala matenda ashuga. Zachidziwikire, kukana kwanu kwa insulin ndi zizindikiro zake kunayamba zaka zambiri izi zisanachitike, osati kokha "shuga atatuluka." Kutsika kwa mphamvu zamagetsi, kutsika kwa libido, kukula kwa kusintha T3, kugona kwambiri, kupsinjika kwakumaso, chifunga cha ubongo zimapangidwa ndendende ndi insulin receptor kukana ndi kutsika kwa shuga mkati mwa khungu, osati chifukwa cha kuchuluka kwa shuga. Mukapezeka ndi matenda a shuga a 2, ndiye kuti amamasuliridwa ku Russia motere: "Tidakhala akatswiri ngati madotolo ndi chithandizo chazachipatala, popeza vuto lanu ndi zizindikiro zakula pang'onopang'ono zaka zambiri mpaka lero ndipo tidalibe nzeru zokwanira kuyeza insulin yanu pamimba yopanda zaka 20 zapitazo ndikufotokozerani chakudya chopatsa thanzi chimakuyendetsa. Pepani. "

Kukodza pafupipafupi komanso kukana insulini.

Shuga owonjezera (glucose) m'magazi amakhala ndi poizoni kwa ma cell kwa nthawi yayitali, kotero thupi lathu limayesetsa kusunga mulingo wake m'magazi mu malo ochepa kwambiri. Mukadzuka m'mawa, ndi magalamu 4-5 a shuga (glucose) okha amene amayenderera m'magazi, pomwe magalamu 6 ali kale 2 shuga. Magalamu 5 ndi supuni yokha.
Chimachitika ndi chiani pamene ma receptor amayamba kukana insulini ndipo shuga sangathe kugawidwa mwachangu komanso moyenera m'maselo? Kodi maselo amayamba kukhala oopsa kwa shuga wambiri? Chowonadi ndi chakuti, mosiyana ndi ma endocrinologists ambiri, thupi laumunthu sililiwongoka komanso ngati dongosolo logawa ma insulin silikuyenda bwino, thupi limachotsa msanga shuga m'magazi kudzera mu impso. Amakhala ndi machitidwe awiri ofunikira (kudzera pachikumbu ndi mkodzo) ndipo akafunika kuti atuluke "mwachangu", amayendetsa "chinthu "cho kudzera mu impso, ndipo atatha kukodza pokodza, ngakhale chikhodzodzo sichinafikebe chokwanira. Mukamalimbana ndi insulini, nthawi zambiri munthu amathamangira kukataya madzi>> kutaya madzi chifukwa cha izi>> pambuyo pake ludzu limamukakamiza kumwa kwambiri ndikubwezeretsa kuchuluka kwa madzi mthupi. Tsoka ilo, anthu amatanthauzira zinthu mosiyana ndi izi, kubweza zomwe zimayambitsa ndikuti: "Ndimamwa kwambiri motero ndimalemba kwambiri!" Zenizeni ndi izi monga izi: "Thupi langa silitha kukhazikika m'magazi chifukwa chokana mafuta a insulin, motero limayesetsa kuchita izi mwachangu ndikuchotsa shuga onse osagwirizana kudzera mkodzo chifukwa ndimakhala ndikumakonda kukodza pafupipafupi maora onse a 2 ndi 2,5. Zotsatira zake zomwe ndimalemba nthawi zambiri, ndimataya madzi ambiri kenako ndikudwala kumakakamizidwa kuti ndikhale ndi kutaya madzi m'thupi. ”Ngati mumakonda kulemba, makamaka ngati mumadzuka kamodzi pa sabata chifukwa chofunitsitsa kukhala ndi pee, ndiye kuti simunapezeke mkodzo Zizindikiro (kupweteka kwa chikhodzodzo, kuwotcha, ndi zina), muli ndi kuthekera kwakukulu + kwa 90%.

Mawu akuti "matenda a shuga" adayambitsidwa ndi dokotala wakale wachi Greek Demetrios waku Apamania ndipo mawuwa amamasuliridwa kuti "kudutsa «, «kudutsa ", Pokumbukira kuti odwala amadzithira okha madzi ngati siphon: awonjezera ludzu ndikuwonjezera kukodza (polyuria).Pambuyo pake, Areteus waku Cappadocia kwa nthawi yoyamba adafotokoza bwino za mtundu wa matenda ashuga amtundu woyamba, momwe munthu amachepera thupi, ngakhale atakhala ndi chakudya chochuluka bwanji kenako ndikufa. Anthu odwala matenda ashuga a mtundu woyamba amakhala ndi vuto la kupangika kwa insulin (chifukwa cha kuwonongeka kwa chitetezo cha pancreas), ndipo popanda insulin yokwanira sangathe kugawa maselo, ngakhale mutadya zochuluka motani. Chifukwa chake, insulini ndiye nambala wambiri ya anabolic m'thupi, osati testosterone monga momwe othamanga ambiri amaganizira. Ndipo chitsanzo cha mtundu woyamba wa odwala matenda ashuga amachiwonetsa bwino - popanda kusowa kwa insulin, minofu yawo ndi mafuta ambiri amasungunuka pamaso pathu, mosasamala kuchuluka kwa chakudya chomwe chimadyedwa kapena masewera olimbitsa thupi. Anthu odwala matenda ashuga a Mtundu wachiwiri amakhala ndi vuto losiyana, ena amakhala ndi mafuta okwanira, koma ambiri amakhala ndi mafuta ochulukirapo pazaka zambiri. Madotolo aku America tsopano apanga liwu loti "diabesity," lomwe ndi mawu oti "shuga" komanso "kunenepa kwambiri". Munthu wonenepa nthawi zonse amakhala ndi insulin. Koma munthu amene amadana ndi insulin nthawi zonse sangakhale wonenepa ndipo izi ndizofunikira kukumbukira !! Ine ndimadziwa anthu omwe ali ndi kuchuluka kwamafuta amthupi, koma nthawi yomweyo amakhala ndi insulin yambiri.

Ndikukhulupirira kuti matenda ngati "mtundu wachiwiri wa shuga" ayenera kuchotsedwa pamankhwala, popeza ndi zinyalala ndipo samuwuza wodwala chilichonse chazomwe zimayambitsa matendawa, anthu sadziwa ngakhale pang'ono zomwe mawu oti "shuga" amatanthauza. Mayanjano oyambilira omwe ali nawo pamutu wawo akamanena mawu awa ndi: "vuto linalake ndi shuga", "odwala matenda ashuga amalowa insulin" ndipo ndizo zonse. M'malo mwa "mtundu wachiwiri wa matenda ashuga", mawu akuti "insulin kukana" magawo osiyanasiyana ayenera kuyambitsidwa: woyamba, wachiwiri, wachitatu ndi wachinayi, pomwe omaliza adzagwirizana ndi phindu la matenda ashuga amtundu wa 2. Osati "hyperinsulinemia", kutanthauza "kukana insulini." Hyperinsulinemia imangotanthauzira ngati "insulin yowonjezera" ndipo sinena chilichonse kwa wodwalayo zakomwe zimayambira, zomwe zimayambitsa komanso tanthauzo la matendawo omwe. Ndikukhulupirira kuti mayina onse amatendawa ayenera kutanthauziridwa mu chilankhulo chosavuta komanso chomveka bwino kwa onse omwe si madotolo, ndipo dzinalo liziwonetsa tanthauzo lake (komanso moyenerera, choyambitsa) vutoli. 80% ya zoyesayesa zamankhwala ziyenera kuyang'ana kukhazikitsa msika wa chakudya ndi maphunziro a anthu pazakudya zopatsa thanzi komanso moyo wokhazikika, ndipo 20% yotsala yokha ndiyomwe iyenera kulangizidwa pothana ndi matenda. Matenda sayenera kuthandizidwa, koma kupewa kudzera mu kuwunikira anthu komanso kuletsa kwathunthu kwa zinthu zotayira zinyalala pamsika wazakudya. Ngati azaumoyo afikitsa anthu kuti alandire chithandizo, chithandizo ichi chakhala chitakwaniritsidwa kale. Inde, m'gulu lathu muli anthu ochepa omwe amatha kuwononga thanzi lawo ndi zinthu zosiyanasiyana “zokoma”, ngakhale kuzindikira kuwonongeka kwawo kwakukulu. Koma unyinji wokulira wa anthu omwe ali ndi zovuta za matenda osachiritsika samachokera ku mphamvu zopanda mphamvu, koma kuchokera ku umbuli woletsa wazakudya wathanzi.

Zizindikiro

Ngati mukumvetsetsa kuti thupi limatha kukhazikika mosavuta komanso mosavuta kulowa m'magazi kudzera mu mkodzo ngakhale pakukhudzana kwambiri ndi insulini, ndiye kuti mumvetsetsanso chifukwa chake kusanthula kwa shuga kapena kusungunuka kwa hemoglobin (kumawonetsa kuchuluka kwa ndende ya magazi masiku 60-90 apitawa - - Ndi zinyalala zopanda pake komanso zosokoneza. Kusanthula uku kukupatsani malingaliro abodza achitetezo ngati shuga m'mawa uzikhala wabwinobwino. Ndipo zomwe zidandichitikira zaka 4 zapitazo - madotolo adayeza kuyeza kwanga kwa shuga ndi glycated hemoglobin ndipo adanditsimikizira kuti palibe vuto. Ndidafunsa mwachindunji ngati ndiyenera kupatsa insulin, pomwe ndidalandira yankho loipa.Kenako sindinkadziwa za shuga kapena za insulin, koma ndinadziwa kuti insulini ndi chimodzi mwamafuta ofunika kwambiri m'thupi.

Kumbukirani, mukamadya chakudya chamadzulo, pafupifupi maola 10 kapena kupitapitilira pamayeso anu a shuga. Munthawi imeneyi, mumapita kawiri kawiri ndipo thupi limakhala ndi nthawi yambiri yolimbitsa shuga. Koma akatswiri ambiri a endocrinologists amakhulupirira moona mtima kuti ngati kuthamanga kwa shuga ndikwabwinobwino kapena kuyesedwa kwa glucose kumawonetsa chizolowezi, ndiye kuti pulogalamu yogawa insulin imagwira bwino ntchito !! Ndipo adzakukhulupirirani mokwanira za izi! Izi sizitanthauza kwenikweni palibe chilichonse ndipo kuyesa kwokhawo komwe kuyenera kugwiritsidwa ntchito ndi kusala insulin chifukwa kokha kumawonetsera kuchuluka kwa kukana kwenikweni kwa ma receptors. Kusala shuga (shuga), glycosylated hemoglobin ndi mayeso a kulolera glucose ndi mayeso atatu a zinyalala omwe alibe ntchito, chifukwa awonetsa kukhalapo kwavuto PAKUTI zinthu zonse zitaipa kwambiri kuposa kale ndipo zidzawonekere ngakhale kwa wakhungu kuti mukudwala kwambiri. Nthawi zina, adzakupatsirani chitetezo chabodza. Kumbukirani, kukana insulini palokha kumapangitsa kuti pakhale kuchuluka, osati kuchuluka kwa shuga ya magazi!

Ingoganizirani kuchuluka kwa insulini kuyambira zero mpaka khumi, pomwe zero ndizomwe zimapangitsa chidwi cha insulin, ndipo 10 ndi mtundu wachiwiri wa matenda ashuga. Mukasunthira kuchoka ku zero kupita ku 1-2 point = mukugwira kale ntchito popanda makina azachilengedwe ndipo mphamvu yanu imakhala yotsikirapo kuposa momwe munasinthidwira ndi chisinthiko. Koma pakadali pano simungakayikirepo za izi. Ngakhale mutakhala ndi kukana kwa insulin kwa mfundo zisanu ndi zinayi, mudzadziwonabe kuti ndinu athanzi. Kukana insulini kukachuluka mpaka kufika pamfundo zisanu ndi zitatu, mudzamvetsetsa: "Pali china chake cholakwika ndi inu," koma kusala shuga ndi glycated hemoglobin kumakhalabe kwabwinobwino! Ndipo zidzakhala zabwinobwino ngakhale mutayandikira kwa mfundo 9! Pafupifupi mphindi 10 zokha ndi pomwe angawululire vuto lomwe mukukhala m'manja mwamakumi ambiri! Chifukwa chake, ndimaganizira shuga komanso kutseka matenda a shuga. Zingowonetsa vutoli mukakumana ndi kukana insulini ndi mfundo 10, ndipo nthawi zina zonse, zimangosokoneza, ndikupatsani malingaliro abodza otetezeka kuti "zomwe zikuwonetsa zizindikiro ndi zina!".
Monga matenda, timagwiritsa ntchito kokha kusala insulin. Kusanthulako kumangotchedwa "insulin" ndipo kumapatsidwa m'mawa pamimba yopanda kanthu (simungathe kumwa chilichonse kupatula madzi akumwa). Kusala insulin yathanzi, malinga ndi madokotala abwino, ili pamtunda wa 2-4 IU / ml.

Timachotsera insulin kukana.

Ndikukumbukiraninso zifukwa zazikulu zotsutsa insulin:
1) Mafuta ambiri a insulini - omwe amapangidwa ndi chakudya omwe amakhala ndi mapuloteni ochulukirapo a nyama ndi mapuloteni a nyama (nawonso amakhala ndi insulinogenic ndipo makamaka mapuloteni amkaka a Whey). Timasinthira kuzakudya zamafuta kwambiri + zomanga thupi komanso zopatsa mphamvu.
2) Kufanana kwa milingo yayikulu-insulin - yopangidwa ndi kuphatikiza zakudya zapafupifupi 5-6 patsiku. Ndipo mufunika 3 pazipita.
3) Mafuta ochulukirapo a visceral
4) Zofooka za magnesium, vitamini D, chromium ndi vanadium.
Zakudya zomanga thupi ndi mapuloteni (makamaka nyama) zimakweza bwino kuchuluka kwa insulin. Mafuta samachikweza.
Phunzirani mosamalitsa ndikukumbukira dongosolo ili. Zakudya zopatsa thanzi zopatsa mphamvu zimayendetsa anthu kutsogolo kwa insulin. Gwero labwino kwambiri lamphamvu zopatsa chidwi ndi FATS !! Ayenera kupereka 60% ya zopatsa mphamvu za tsiku ndi tsiku, mapuloteni 20% ndi chakudya 20% (mwanjira yabwino, chakudya chimayenera kutengedwa kuchokera ku zipatso ndi ndiwo zamasamba kapena mtedza). Makina ofanana kwambiri azachilengedwe, ma chimpanzee ndi ma bonobos, kuthengo amatenga pafupifupi 55-60% ya zopatsa mphamvu za tsiku ndi tsiku kuchokera ku mafuta !!

CHIKWANGWANI ndi mafuta zimachepetsa kuyamwa kwa chakudya chamafuta m'mimba ndipo chifukwa chake zimathandiza kuti insulini isalumphe. Malinga ndi Jason Fang, m'chilengedwe, poizoni amabwera m'modzi ndimankhwala - chakudya mu zipatso zambiri ndi ndiwo zamasamba zimabwera ndi fiber yokwanira.
Malangizo omwe ali pamwambawa angakuthandizeni kupewa kukana insulini, koma bwanji ngati muli nacho kale? Kodi kungosinthana ndi mafuta kukhala gwero lalikulu la mphamvu ndi kuchepetsa kuchuluka kwa chakudya mpaka katatu patsiku kungakhale kothandiza? Tsoka ilo, izi sizothandiza kuthana ndi zovuta zomwe zilipo kale za insulin. Njira yothandiza kwambiri ndi kungopatsa ma receptor anu kuti atuluke ku insulin KONSE. Thupi lanu limayesetsa nthawi zonse kukhala wathanzi momwe mungathere ndipo ma receptor enieniwo adzabwezeretsa insulini kumva popanda mapiritsi kapena zowonjezera, ngati mungosiya kuphulitsa ndi insulin ndikuwapatsa "kupumula" kwa icho. Njira yabwino ndiyakuti musale kudya nthawi ndi nthawi, pomwe msinkhu wanu wa shuga ndi insulin umatsikira pang'onopang'ono ndipo nthawi yonseyi kumverera kumatsika pang'onopang'ono. Kuphatikiza apo, pamene ma glycogen depots (malo a shuga a chiwindi) alibe, izi zimakakamiza maselo kuti apite mu regimen yowonjezera kumverera kwa insulin ndipo amachotsa pang'onopang'ono kukana.

Pali njira zambiri zosala nthawi ndi nthawi: kuchokera pakusala kudya kwathunthu kwa masiku angapo motsatizana mpaka kusala kudya kwa tsiku ndi tsiku mpaka chakudya chamasana, i.e. Kudumpha kadzutsa ndikusiya chakudya chamadzulo komanso chakudya chamadzulo.

1) Njira yabwino komanso yachangu kwambiri yomwe ndimaganiza kuti ndi "masiku awiri amanjala - imodzi (kapena iwiri) yokhutitsidwa bwino" ndikuzungulira kubwereza. Patsiku lanjala, timadya magalamu 600-800 a letesi (14 kcal 100 magalamu) kapena magalamu 600-800 a kabichi yaku China (13 kcal 100 magalamu) tisanayambe kugona, kuti tizingodzaza m'mimba mwathu ndi zakudya zama calorie ochepa, kuthetsa ludzu lathu, komanso kugona mwamtendere. Patsiku lokometsedwa, sitiyesa kudya ndikudya, koma timangodya monga momwe timakhalira patsiku lathunthu ndipo osamadya zakudya zamtengo wapatali monga mpunga, tirigu, oatmeal, mbatata, zakumwa zotsekemera, ayisikilimu, ndi zina zambiri. Palibe mkaka, chifukwa Ndi insulinogenic kwambiri, ngakhale otsika mafuta. Pomwe tikukonzanso chidwi cha ma receptor kuti insulini, ndibwino kuti musangogwiritsa ntchito zinthu zonsezi. Mutha kudya masamba, mtedza, nyama, nsomba, nkhuku, zipatso zina (makamaka ndi index ya glycemic, maapulo mwachitsanzo)
Malinga ndi odwala, masiku awiri oyamba okha ovuta amakhala ovuta m'maganizo. Munthu akakhala ndi njala nthawi zambiri, thupi limamangiridwanso kuti igwetse mafuta, njala yochepa imatsala ndipo mphamvu zambiri zimawonekera. Njira iyi ndi yothandiza kwambiri ndipo pakangotha ​​milungu ingapo mutha kuona kusiyana kwakukulu pamlingo wamphamvu. Pangatenge mwezi kapena awiri kuti azisinthasintha mphamvu za insulin, ndipo kwa anthu omwe ali ndi vuto lakukhudzidwa kwambiri atha kutenga pafupifupi 3-4. Monga ndidanenera, mudzaona kusiyanasiyana kwamphamvu komanso mphamvu zamagetsi m'masabata angapo ndipo kuyambira pano izi zikuthandizani kuti musayime. Muyenera kubwezeretsanso insulin pokhapokha ngati mwadwala masiku ambiri komanso osagwirizana ndi tsiku lanjala, apo ayi mudzawona chithunzi chosokonekera bwino. Mlingo ndi glycemic index pazakudya zamadzulo zimakhudza kuchuluka kwa insulin yam'mawa pamimba yopanda kanthu.
Kumbukirani kuti mukakhala ndi njala nthawi yayitali, michere yambiri ya insulin imabwezeretsedwa ku insulin. Ndipo akuchira mwachangu tsiku lachiwiri lanjala, chifukwa ogulitsa glycogen amangotsirizika kumapeto kwa tsiku loyamba.
2) Mutha kusinthana tsiku limodzi lanjala - chodala bwino ndipo izi zithandizanso, ngakhale sizabwino ngati njira yoyamba.
3) Anthu ena amasankha kudya kamodzi kokha patsiku - chakudya chamadzulo, koma popanda zakudya za insulinogenic monga tirigu, mpunga, oatmeal, mkaka, zakumwa zotsekemera, etc.Nthawi yonse mpaka chakudya chamadzulo, amakhala ndi njala ndipo panthawiyi chidwi cha zolandiracho chimabwezeretseka.
4) Njira ina ndi yomwe amati "chakudya cha wankhondo" - mukamakhala ndi njala tsiku lililonse kwa maola 18-20 ndikudya pawindo lomaliza la maola 4-6 musanagone.
5) Mutha kudumphira chakudya cham'mawa chokha, pafupifupi maola 8 mutadzuka kumakhala chakudya chamadzulo cham'mawa komanso chamadzulo chamadzulo, koma zotere sizothandiza kwenikweni.
Monga mukuwonera, kusala kudya kwakanthawi kumakhala ndi mitundu yambiri yosiyanasiyana ndipo muyenera kusankha chiwembu chomwe chikugwirizana bwino ndi chilimbikitso chanu. Ndizachidziwikire kuti njira yothamanga kwambiri yomwe mungabwezeretsere insulin ndikumawotcha mafuta ambiri pachiwonetsero choyamba, koma ngati zikuwoneka zolemetsa kwambiri kwa inu, ndibwino kumamatira ku chiwembu cha 5 kuposa kuti musachite chilichonse. Ine ndikulangizani aliyense kuti ayese njira yoyamba kapena "tsiku lanjala tsiku lonse" ndikukhala tsikulo 4-5, mudzadabwa momwe zidzakhalire zosavuta kuti mupitirize kusala. Munthu akangokhala ndi njala, zimakhala zosavuta.
Kodi njala idzachepetsa kagayidwe kachakudya ndikupangitsa kusokonezeka kwakuthengo? Maola 75-80 oyamba a njala yathunthu, thupi silimawona ngati chifukwa chodera nkhawa ndipo silinayambenso kuchepetsa kagayidwe. Adzayamba kuchita izi pa tsiku la 4, osadziwa kuti chitukuko cha T3 chatsimikizika ndikumaliza izi pang'onopang'ono pa 7. Ndipo sasamala ngati kunali njala yonse kapena kuchepa 500 kcal pakudya. Patsiku la 4, adzayamba kuzolowera kusowa kwa zopatsa mphamvu zobwera ndi chakudya ndikumanganso kuti ogwiritsira ntchito calorie tsopano agwirizane ndi chiphaso chawo pachakudya. Chifukwa chake, sindipangira munthu aliyense kuti afe ndi njala kwa masiku opitilira masiku awiri mzere. Tanthauzo la tsiku lopatsidwa bwino ndikulepheretsa thupi kuti muchepetse kuchepa kwa kagayidwe ndikupita muzinthu zachuma zadzidzidzi. Ndipo kenako kuzungulira kumabwereza.
Mungamve zambiri kuchokera kwa akatswiri osiyanasiyana azakudya zopanda thanzi komanso madokotala amitundu yonse yosangalatsa yokhudza kusala kudya kwakanthawi. Kwenikweni, kusala kudya kwakanthawi kumangokulitsa kuchuluka kwa kagayidwe kake mwakuchotsa insulin. Kumbukirani kuti kusowa kwathunthu kwa chakudya masiku angapo ndi vuto lililonse kwa anthu obadwa nawo, zimachitika chifukwa cha zomwe zimachitika kuti thupi lathu limasunga mafuta. M'malo mwake, thupi silipita popanda chakudya, mukangosiya kuponya zakunja mkati mwake, iyamba kugwiritsa ntchito ma kilogalamu ambiri a "chakudya" chimenecho chomwe chimanyamula nthawi zonse patsiku lakugwa mvula m'chiuno, m'chiuno, matako, ndi zina. .
Ndipo nthawi zonse muzikumbukira kufunsa othandizira anu azaumoyo! Pali anthu ochepa omwe, chifukwa cha kukhalapo kwa mavuto ena mthupi, sayenera kufa ndi njala. Koma ocheperako ochepa.

Mu Seputembala, ndidapitanso ku China, ndipo zidali zosatheka kutsatira keto. Osatero chifukwa kupeza nyama yopanda shuga kungakhale kovuta. Keto ndi LCHF kwa ine ndi machitidwe azakudya, komwe thanzi limabwera koyamba, timayang'anira mtundu wa zogulitsa. Ng'ombe zodyetsedwa bwino, mafuta a azitona ndi ghee ndizopatsa zapamwamba kwambiri ku China. Malita okha a peanut, hardcore okha.

Ndidasiya kudya zokhazikika, ngakhale ndimalumikizana kusala nthawi ndi nthawi ndimatsuka nkhuku yokazinga ku msuzi wokoma ndi wowawasa.

Kutopa kokwanira, kugona, njala - Ndinaganiza kuti chinthucho chinali choti ndimayenera kuganizira zilankhulo zitatu ndikulankhula zinayi. Zachidziwikire, kuti ine ndine nyama yonenepa yopanda tanthauzo.

Mu Januware, ndidafika ku Kazan ndipo ndidayamba kufunafuna ntchito. Tsopano ndine katswiri mu nyuzipepala ya pa intaneti "Realnoe Vremya", ndikaweruka kuntchito ndithamangira kukawerenga, komwe kumakhalako mpaka eyiti madzulo. Zakudya zomwe zili mumtsuko, njala yausiku komanso kusowa tulo zimaphatikizidwa.

Posakhalitsa ndidazindikira kuti chakudya changa cham'mawa - mazira awiri omwe amakhala ndi masamba ndi tchizi / nyama yankhumba - amandikhalira ngati oatmeal pamadzi.Pambuyo pa nkhomaliro, ndimakhala ndi zhor chakuthengo, ngakhale gawo langa lokhazikika ndi: hakika sauerkraut + masamba ena, osiyanasiyana monga momwe angathere, ophika ndi batala / ghee, ndi ng'ombe, nkhumba za nkhumba. Njala "idachepetsedwa" ndi mchere - chokoleti chowawa, mtedza kapena apulo, koma sizinakhale bwino. Nthawi yomweyo, ndinayesetsa kuti ndisatope. Chakudya chamadzulo, chomwe ndimafuna kuthamanga pakati pa maanja, chimangokulira.

Mavuto osamba abwerera, adayamba kuchepa. Ndalumikiza izi ndi chakudya chamagulu pang'ono komanso katundu wolemera, kotero ndidayamba kuwonjezera chakudya changa masiku atatu kapena anayi aliwonse. Zinandithandiza, ngakhale sanandigwiritse ntchito. Nditafika pansi pamataya mtima, Katy Young @ wow.so.young adalandira positi yochepetsa chakudya. Ndizodabwitsa kuti sindinazengereze kumulembera.

Kutsiliza: Chizindikiro chogwira mtima kwambiri ndi chakudya mutatha kudya. Ingotsimikizirani kuti muli ndi magawo abwino omwe amakukwaniritsani m'mbuyomu. Ndingafotokoze motere: "Ndadya kwambiri, koma apa mphutsi yaying'ono yakhumudwitsa ikupempha maswiti, ipatseni, kenako ndidzakhuta."

Ndi insulin yayikulu, ndizovuta kwambiri kuchepetsa thupi, kotero ngati mumadya chakudya chokwanira ndipo kulemera kwake ndikoyenera, iyi ndi belu lodabwitsa.

Atsikana ayenera kuyang'anira zolephera pamazungulira.

Kukana kwa insulini kumathandizidwanso ndi mutu, kutopa ndi kuperewera, kugona pang'ono, mavuto okhala ndi nkhawa.

Zotsatira zake

Nthawi zambiri matendawa amakula pakati pa anthu onenepa kwambiri komanso omwe amakhala ochepa matenda oopsa. Kukana kwa insulin nthawi zambiri kumakhala kosadziwika mpaka zovuta za metabolic zimachitika.

Kufikira pamapeto, makina a kupezeka kwa insulin kukhudzidwa sanaphunzire. Pathologies omwe amatsogolera kukana insulini amatha kukhala pamagawo otsatirawa:

• prereceptor (insulin yachilendo),
• receptor (kutsika kwa chiwerengero kapena kuyanjana kwa receptors),
• mulingo wa mayendedwe a shuga (kuchepa kwa ma mamolekyulu a GLUT4)
• postreceptor (kufalikira kwa chiwonetsero cha mkhutu ndi phosphorylation).

Pakadali pano, akukhulupirira kuti chifukwa chachikulu chachitukuko cha matenda amtunduwu ndi kusokonezeka kwa post-receptor level.

Kukana insulini nthawi zambiri kumayamba ndi kunenepa kwambiri. Chifukwa chakuti minofu ya adipose imakhala ndi zochita zapamwamba kwambiri, chidwi cha minofu kupita ku insulin chimachepetsedwa ndi 40% pamene kulemera koyenera kwa thupi kumadutsa ndi 35-40%.

Zotsatira zake

Lingaliro la kukana insulini komanso zifukwa zake. Kodi kukana insulini

Kukana insulini kwa thupi lanu mwina ndi vuto lalikulu kwambiri la mahomoni ndipo ndi chimodzi mwazomwe zimayambitsa kutopa kwambiri. Anthu ambiri omwe amagwiritsa ntchito zakudya zamafuta monga gwero lawo lalikulu la ma calorus amakhala ndi insulin yolimbana ndi zovuta zosiyanasiyana. Ndipo akadzakula, ndiye kuti insulini yolimbana ndi maselo awo imayamba.

Musaganize kuti ngati shuga yanu yosala kudya komanso glycated hemoglobin ndiyabwino, ndiye kuti "mulibe mavuto okana ndi insulin." Umu ndi momwe ma endocrin amatanthauzira zaka zanga zapitazo ndipo ndinalipira chifukwa cha kupusa kwawo zaka zambiri chifukwa cha insulin kukana komanso hypothyroidism. Ndikadakhala ndi ubongo wokwanira kuti ndisamamvere kwambiri ng'ombe zawo, kuti ndizingopereka insulin pamimba yopanda kanthu ndikufanizira zomwe zili ndi moyo wathanzi malinga ndi akatswiri, ndikadachiritsidwa kale. Kugwiritsa ntchito kwambiri kapena kosapatsa thanzi insulini ndi 3-4 IU / ml, pomwe 5 IU / ml ndi apamwamba ndi magulu osiyanasiyana a zovuta. Ndipo musadabwe ngati "pazifukwa zina, ma deiodinases safuna kusintha T4 yanga kukhala T3, ngakhale insulini yanga yachangu ndi 9 me / ml (2.6 - 24,9)." Mitundu iyi (2.6 - 24,9) ilibe chochita ndi thanzi ndipo zitha kuwoneka kuti kusala kwanu kwa 6 IU / ml kapena 10 IU / ml ndi "kwabwino".

Insulin ndi chimodzi mwamafuta atatu ofunika kwambiri m'thupi la munthu (limodzi ndi T3 ndi cortisol).Ntchito yake ndikuwadziwitsa maselo pamene michere ilipo m'magazi: shuga, amino acid, mafuta, micronutrients, ndi zina zambiri. Pambuyo pake, mapuloteni apadera omwe ali m'chipindacho, otchedwa glucose transmit, amayandikira kumtunda kwa cell ndikuyamba "kuyamwa" michere yonseyo m'selo. Maselo alibe maso chifukwa chake amafunika kulumikizana nthawi yanji komanso mwachangu momwe "angatenge" michere kuchokera m'magazi. Maselo amtundu wanji? - Ndi zomwe. Minyewa, hepatic, mafuta, endocrine, maselo aubongo ndi zina zotero. Kuti ikhale yosavuta, chizindikiro cha insulin ku Russia imamveka ngati: "Selo, tenga michere!". Chifukwa chake, insulin nthawi zambiri imatchedwa "mphamvu yosungirako mphamvu" kapena "mayendedwe othandizira", ngati kuti "imasamutsa" michere kupita ku cell, ngakhale palibe chilichonse chamtunduwu chimachitika mu tanthauzo lenileni la mawu, mahomoni amangotumiza mauthenga kuchokera ku selo limodzi kupita ku lina. Ndimakonda kuzitcha kuti "mphamvu yamagetsi yamagetsi", ndi T3 - mphamvu yamafuta. Ma insulin ma cell amawongolera kuchuluka kwa michere / mphamvu zomwe zimalowa mu cell, ndipo ma T3 ma sign akuwongolera kuchuluka kwa mphamvu zomwe mphamvuzi zimawotchedwa m'chipindacho. Pazifukwa izi, zizindikiro za insulin kukana ndizofanana kwambiri ndi zizindikiro za hypothyroidism. Ndipo, mwina, chifukwa chokana kwambiri ndi insulini (zolandilira sizimva bwino chizindikiro kuchokera ku insulini ndipo michere imalowa mu cell pang'onopang'ono / zochepa)) deiodinases imachepetsa kutembenuka kwa T4 mpaka T3 ndikuwonjezera kutembenuka ndikusinthanso T3. Ngati mphamvu ilowa m'selo pang'onopang'ono, ndiye kuti ndiyotentha pang'ono pang'onopang'ono, apo ayi mutha kuwotcha chilichonse ndikusiya khungu "popanda mphamvu". Ili ndi lingaliro langa chabe, ndipo sizingafanane ndi zenizeni. Koma kwa ife, chinthu chimodzi chokha ndichofunikira - kukana insulini kumabweretsa kuchepa kwa kutembenuka kwa T4 kukhala T3 ndikuwonjezereka kwa T3. Ndipo ichi ndiye chowonadi chotsimikiziridwa ndi kafukufuku, osati malingaliro anga. Insulin imapangidwa ndi maselo a pancreatic beta akafunsidwa "kuchokera kumwamba."

Kuthetsa chithunzi cha insulin

Insulin, yokha, siyikofunikira kuti ipangidwe panthawi yake masana. Inu nokha mumalimbikitsa kutulutsa kwa insulin panthawi yoyenera, komanso m'malo oyenera. Ndipo pali njira zowongolera njirayi.

Muyenera kusankha zomwe zimakusangalatsani - kumanga minofu, kapena kuchotsa mafuta.

"Ndimangofuna kumanga minofu!"
Ngati cholinga chanu chachikulu ndikupanga minofu, muyenera kusamalira kuchuluka kwa insulin tsiku lonse.

Ndikofunikira kwambiri kuti zitsimikizire kuchuluka kwambiri kwa insulin mukangolimbitsa thupi, monga panthawiyi, minyewa yam'mimba imakhala yovomerezeka ku insulin ndi zonse zomwe zimanyamula nayo (mwachitsanzo, glucose, BCAA).

"Ndikufuna ndichotse mafuta!"
Ngati cholinga chanu ndi kuchepa kwamafuta kokha, muyenera kukhala ndi, pafupifupi, kuchuluka kwambiri kwa insulin tsiku lonse.

Lingaliro loyamba mwa anthu ena limakhala loti njira yochotsera mafuta ndikusunga insulin tsiku lonse, tsiku lililonse. Inde, koma pokhapokha malingaliro anu ataphunzitsidwa atatsika poyenda ndi alley.

Ngakhale mulibe chidwi pakupanga minofu, ndikofunikira kwambiri kuyambitsa kupanga insulini pambuyo pophunzitsidwa mwamphamvu. Izi zitha kusiya kugwiritsa ntchito masewera olimbitsa thupi, komanso kuwongolera glucose ndi ma amino acid m'maselo a minofu. Kupanda kutero, mudzazindikira kuti mukutaya minofu yamtengo wapatali, motero mukusokoneza kayendedwe ka metabolic komwe kamayaka mafuta.

Simukufuna kuwoneka ngati mafupa ophimbidwa ndi khungu mutachepetsa thupi, sichoncho? Ndipo ndizomwe mungasinthe ngati simupereka minofu yanu ndi ma amino acid omwe amafunikira.

"Ndikufuna ndimange minofu ndikuchotsa mafuta."
Zachisoni, ambiri sakhulupirira kuti ndizosatheka kumanga minofu ndikumataya mafuta.

Sinthani insulin

Chilichonse chomwe mungasankhe, kumbukirani kuti kusinthaku sikuyenera kukhalabe komweko kwa miyezi. Pezani insulin masana, ndipo mutha kupambana, kupewa zovuta.

Kodi kuphwanya kumeneku nkowopsa?

Izi matenda oopsa chifukwa cha matenda omwe amadza pambuyo pake. Choyamba, ndi matenda amtundu wa 2 shuga.

Mu njira za matenda ashuga, makamaka minofu, chiwindi ndi mafupa amafuta zimakhudzidwa. Popeza mphamvu ya insulini imalekeka, shuga amasiya kudyedwa mu kuchuluka komwe kuyenera. Pazifukwa zomwezi, maselo a chiwindi amayamba kupanga mwachangu ndikuphwanya glycogen ndikupanga shuga kuchokera ku mankhwala a amino acid.

Ponena za minofu ya adipose, mphamvu yotsutsana nayo imachepa. Pa magawo oyamba, njirayi imalipiriridwa ndi kupititsa patsogolo kapangidwe ka insulin mu kapamba. Pa magawo apamwamba, malo osungirako mafuta amagawika ma mamolekyulu amafuta achilengedwe ndi glycerol, munthu amalemera kwambiri.

Zinthuzi zimalowa m'chiwindi ndipo zimakhala lipoproteins zotsika kwambiri. Zinthu izi zimadziunjikira pamakoma a mtima ndikuyambitsa chitukuko cha atherosulinosis. Chifukwa cha njirazi zonse, glucose wambiri amatulutsidwa m'magazi.

Nocturnal Insulin Resistance

Thupi limakonda kwambiri insulin m'mawa. Izi zimawoneka zosavuta masana. Kwa thupi la munthu, pali mitundu iwiri yamagetsi: usiku ndi usana.

Masana, mphamvu zambiri zimatengedwa makamaka kuchokera ku glucose, malo ogulitsa mafuta samakhudzidwa. Zosiyana zimachitika usiku, thupi limadzipatsa mphamvu, zomwe zimamasulidwa ku mafuta acids, omwe amatulutsidwa m'magazi pambuyo pakuwonongeka kwamafuta. Chifukwa cha izi, insulivityity imatha kufooka.

Ngati mumadya makamaka madzulo, ndiye kuti thupi lanu silingathe kupirira kuchuluka kwa zinthu zomwe zimalowa. Izi zimatha kubweretsa mavuto akulu azaumoyo.

Kwa kanthawi, kusowa kwa insulin nthawi zonse kumalipidwa ndi kuchuluka kwa zinthu zomwe zimapezeka m'maselo a beta. Vutoli limatchedwa hyperinsulemia ndipo limadziwika ndi matenda ashuga. Popita nthawi, kuthekera kwa maselo kupanga insulin yambiri kumachepa, kuchuluka kwa shuga kumawonjezeka, ndipo munthu amakula ndi matenda ashuga.

Komanso, insulin kukana ndi hyperinsulinemia ndi zinthu zolimbikitsa matenda a mtima dongosolo. Chifukwa cha insulin, kuchuluka ndi kusuntha kwa minofu yosalala, kuchuluka kwa ma fibroblasts, komanso kuletsa kwa njira za fibrinolysis kumachitika. Chifukwa chake, kunenepa kwambiri kwam'mimba kumachitika ndi zotsatirapo zonse zotsatirazi.

Kukana kwa pakati

Ma molekyulu a glucose ndiye gwero lamphamvu kwa onse mayi ndi mwana. Panthawi yakukula kwa mwana, thupi lake limayamba kufuna kuchuluka kwa glucose ochulukirapo. Chofunikira ndichakuti kuyambira pa 3 trimester ya mimba, zofuna za shuga zimapezekanso.

Nthawi zambiri, makanda amakhala ndi shuga wotsika magazi kuposa amayi. Mu ana, pafupifupi 0,6-1.1 mmol / lita, ndipo mwa akazi, 3.3-6.6 mmol / lita. Mbewu ikakula ikafika pamtengo wokwanira, mayi amatha kuyamba kukhala ndi insulin.

Glucose onse omwe amalowa m'thupi la amayi kwenikweni samangiriridwa ndipo amatumizidwa kwa mwana wosabadwayo kuti asasowe michere pakukula.

Izi zimayendetsedwa ndi placenta, yomwe ndiye gwero loyambirira la TNF-b. Pafupifupi 95% yazinthu izi zimalowa m'magazi a mayi wapakati, zotsalazo zimalowa m'thupi la mwana. Ndiye kuwonjezeka kwa TNF-b komwe ndiko chifukwa chachikulu cha kukana insulin panthawi ya bere.

Pambuyo pobadwa kwa mwana, msinkhu wa TNF-b umatsika mwachangu komanso mofanananira, kumva kwa insulin kumabwereranso. Mavuto amatha kuchitika mwa azimayi onenepa kwambiri, chifukwa amapanga TNF-b yochulukirapo kuposa amayi omwe ali ndi thupi labwinobwino. Mwa akazi otere, kukhala ndi pakati kumakhala nthawi zambiri kumayendetsedwa ndi zovuta zingapo.

Kukana kwa insulini nthawi zambiri kumatha ngakhale pakubala, pamakhala kuchuluka kwakukulu kwa matenda ashuga. Ngati kutenga pakati ndikwabwinobwino, kukana kumathandizira kuti mwana akule.

Kuphwanya kudziwa kwa insulin mu achinyamata

Mwa anthu akutha msinkhu, kukana insulini nthawi zambiri kumachitika. Chosangalatsa ndichakuti kuchuluka kwa shuga sikokwanira. Pambuyo pa kutha msambo, mkhalidwe umakonda kusinthika.

Pa kukula kwambiri, mahomoni a anabolic amayamba kupangika kwambiri:

Ngakhale zotsatira zake ndizosiyana, amino acid metabolism ndi glucose metabolism sikuvutikira. Ndi comperatory hyperinsulinemia, kupanga mapuloteni kumatheka ndipo kukula kumakhudzidwa.

Mitundu yambiri ya kagayidwe ka insulin imathandizira kulumikizana kutha msinkhu komanso njira za kukula, komanso kusunga magwiridwe anthawi ya metabolic. Ntchito yofananira yotere imapereka mphamvu kusunga ndalama mosakwanira muzakudya, imathandizira kutha msinkhu komanso kulera komanso kubereka ana omwe ali ndi chakudya chokwanira.

Kutha msambo kutha, kuchuluka kwa mahomoni ogonana kumakhalabe okwera, ndipo insulinitivity imatha.

Chithandizo cha insulin

Asanayambe nkhondo yolimbana ndi insulin, madokotala amayesa wodwala. Pozindikira matenda am'mbuyomu komanso mtundu wachiwiri wa matenda ashuga, mitundu ingapo ya mayeso a labotale imagwiritsidwa ntchito:

• Chiyeso cha A1C,
• Kuthamanga kuyesera kwa plasma glucose,
• Mayeso a kulolera a glucose.

Matenda a 2 a mtundu wa 2 amadziwika ndi 6.5% malinga ndi kuyesa kwa A1C, kuchuluka kwa shuga kuchokera pa 126 mg / dl ndipo zotsatira kuchokera poyesa komaliza kuposa 200 mg / dl. Mdziko loyambirira la matenda ashuga, chisonyezo cha 1 ndi 5.7-6.4%, chachiwiri ndi 100-125 mg / dl, chomaliza ndi 140-199 mg / dl.

Mankhwala

Zizindikiro zazikulu zamtunduwu wa mankhwalawa ndi chisonyezo cha thupi chopitilira 30, chiopsezo chachikulu chotenga matenda a mtima ndi mtima, komanso kukhalapo kwa kunenepa kwambiri.

Kuti muwonjezere mphamvu ya shuga, mankhwala otsatirawa amagwiritsidwa ntchito:

• Biguanides
  Kuchita kwa mankhwalawa cholinga chake ndikulepheretsa glycogeneis, kuchepetsa kupanga shuga mu chiwindi, kuletsa kuyamwa kwa shuga m'matumbo ang'ono, komanso kukonza insulin.
• Acarbose
  Chimodzi mwazithandizo zotetezeka. Acarbose ndi blocker alpha-glucosidase blocker chapamwamba m'mimba. Zimasokoneza machitidwe a polysaccharide ndi oligosaccharide cleavage ndikuwonjezereka kwa zinthu izi m'magazi, ndipo kuchuluka kwa insulin kumachepa.
• Thimang
  Kuchulukitsa kumverera kwa insulini mu minofu ndi mafuta ululu. Othandizira awa amalimbikitsa mitundu yayikulu yamitundu yomwe imayambitsa kumva. Zotsatira zake, kuwonjezera pa kulimbana ndi kukana, kuchuluka kwa shuga ndi ma lipids m'magazi kumachepa.

Ndi kukana kwa insulini, kutsimikizika kumakhala pa chakudya chamafuta ochepa kupatula kufa ndi njala. Fractional mtundu wa zakudya tikulimbikitsidwa, iyenera kukhala kasanu mpaka kasanu ndi kawiri patsiku, poganizira zokhwasula-khwasula. Ndikofunikanso kumwa madzi okwanira, osachepera 1.5 malita patsiku.

Wodwala amaloledwa kudya chakudya chochepa pang'onopang'ono. Itha kukhala:

1. Porridge
2. Rye ufa wophika zinthu
3. Zamasamba
4. Zipatso zina.

Ndi chakudya chamafuta ochepa, wodwalayo sayenera:

• Mpunga Woyera
• Mafuta ndi nsomba
• Zakudya zonse zotsekemera (zopatsa mphamvu)

Zakudya zonse zomwe wodwala amadya ziyenera kukhala ndi index yotsika ya glycemic.Mawuwa ndi chizindikiro cha kuwonongedwa kwa zinthu zamafuta atalowa m'thupi. Potsikira chizindikiro ichi chazomwe zimapangidwira, ndizomwe zimayenerera wodwala.

Zakudya zolimbana ndi insulin zimapangidwa kuchokera ku zakudya zomwe zimakhala ndi index yotsika. Ndikosowa kwambiri kudya kena kokhala ndi GI yapakatikati. Njira yakukonzera mankhwala nthawi zambiri ilibe mphamvu pa GI, koma pali zosiyana.

Mwachitsanzo, kaloti: ikakhala yosakongola index yake ndi 35 ndipo imatha kudyedwa, koma kaloti wowiritsa ndi wamkulu kwambiri GI ndipo ndizosatheka kuidya.

Zipatso zimathanso kudyedwa, koma muyenera kudya zosaposa 200 magalamu patsiku. Ndikosatheka kukonzekera madzi obwera kuchokera kwa iwo, chifukwa pamene zamkati zimaphwanyidwa, CHIKWANGWANI chimatha ndipo msuzi umapeza GI yayikulu kwambiri.

GI ikhoza kugawidwa m'magulu angapo:

1. Mpaka 50 - otsika
2. 50-70 - yowonjezera,
3. Zoposa 70 ndi zazikulu.

Pali zakudya zina zomwe zilibe index ya glycemic konse. Kodi ndizotheka kuzidya ndi insulin? - ayi. Pafupifupi nthawi zonse, chakudya choterocho chimakhala ndi zopatsa mphamvu kwambiri, ndipo simungathe kudya chimodzi chokhala ndi vuto la insulin.

Palinso zakudya zomwe zili ndi kalozera kakang'ono ndi zambiri zopatsa mphamvu:

Zakudya zopatsa thanzi kwa wodwala ziyenera kukhala zosiyanasiyana. Iyenera kukhala ndi nyama, zipatso, masamba. Zinthu zopangidwa ndi glucose zimalimbikitsidwa kudyedwa asanadutse 15:00. Msuzi amaphika bwino msuzi wamasamba, nthawi zina zimakhala zovomerezeka kugwiritsa ntchito msuzi wachiwiri.

Pazakudya zama carb ochepa, mutha kudya mitundu iyi ya nyama:

1. Chiwindi (nkhuku / ng'ombe),
2. Turkey,
3. Chikuku
4. Ng'ombe
5. Kalulu nyama
6. Nyama ya Quail
7. Ziyankhulo.

Kuchokera ku nsomba mumatha kukwera, pollock ndi nsomba. Amayenera kudyedwa osachepera 2 pa sabata. Kwa phala yokongoletsa ndiyabwino kwambiri. Amawiritsa m'madzi, sangawerengeredwe ndi nyama.

Mutha kudya zipatso monga izi:

Nthawi zina mutha kudzichitira nokha pasitala kuchokera ku tirigu wa durum. Mutha kudya dzira limodzi la dzira patsiku musanafike mapuloteni. Pazakudya, mutha kudya mkaka wonse kupatula womwe uli ndi mafuta ambiri. Itha kugwiritsidwa ntchito pakudya masana.

Malonda otsatirawa ali pamndandanda wobiriwira:

• Curd
• Mkaka
• Kefirs,
• Kirimu mpaka 10%,
• Yogurts zopanda mafuta,
• Tofu
• Ryazhenka.

Gawo lamkango la mkango liyenera kukhala ndi masamba. Mutha kupanga saladi kapena mbale yam'mbali kwa iwo.

Mloza wotsika kwambiri m'masamba ngati awa:

1. Garlic ndi anyezi,
2. Biringanya
3. Nkhaka
4. Tomato
5. Tsabola wa mitundu yosiyanasiyana,
6. Zukini,
7. Kabichi iliyonse
8. Nandolo zatsopano ndi zouma.

Wodwalayo sakhala ndi malire pazakudya ndi zonunkhira. Oregano, basil, turmeric, sipinachi, parsley, katsabola kapena thyme amatha kusiyanitsidwa bwino ndi mbale.

Ndikofunika kuphatikiza muzakudya zanu:

• Currant
• Plums
• Mapeyala
• Rabulosi
• Blueberries
• Maapulo
• Apricots
• Nectarines.

Mutha kudya zakudya zambiri zosiyanasiyana pa zakudya zamafuta ochepa. Musawope kuti zakudya zanu sizikhala zosasangalatsa komanso zodandaula.

Kusewera masewera

Akatswiri a masewera olimbitsa thupi amakhulupirira kuti kuchita masewera olimbitsa thupi ndi njira yothandiza kwambiri yolimbana ndi insulin. Pa maphunziro, insulin sensitivity imawonjezeka chifukwa cha kuchuluka kwa mayendedwe a glucose panthawi yopanga minofu.

Pambuyo pa katundu, mphamvuyo imachepa, pomwe njira za insulin mwachindunji zimayamba. Chifukwa cha zotsatira zake za anabolic komanso anti-catabolic, insulin imathandizira kuperewera kwa glycogen.

M'mawu osavuta, atalemedwa, thupi limatenga mamolekyulu a glycogen (glucose) momwe angathere ndipo, pambuyo pophunzitsidwa, thupi limatha glycogen. Kuzindikira kwa insulin kumawonjezeka chifukwa chakuti minofu ilibe mphamvu zotsalira.

Izi ndizosangalatsa: madokotala amalimbikitsa kuyang'ana kwambiri pophunzitsa anthu odwala matenda ashuga a 2.

Aerobic kulimbitsa thupi ndi njira yabwino yolimbana ndi insulin.Pa katunduyu, shuga amapsa mwachangu. Kugwiritsa ntchito kwa Cardio pang'ono kapena kwambiri kumatha kukulitsa chidwi masiku asanu ndi anayi otsatirawa. Kusintha kowoneka kwalembedwa patadutsa sabata yophunzitsidwa ndi zolimbitsa thupi zosachepera ziwiri za Cardio.

Ngati makalasi amachitika nthawi yayitali, mphamvu zolimba zimatha kupitilira kwa nthawi yayitali. Ngati nthawi ina munthu angosiya masewera mwadzidzidzi ndikupewa kulimbitsa thupi, kukana insulini kudzabweranso.

Katundu wamphamvu

Ubwino wophunzitsira mphamvu sikuti umangokulitsa chidwi cha insulin, komanso kumanga minofu. Amadziwika kuti minofu imatenga kwambiri mamolekyulu a glucose osati panthawi yonyamula yokha, komanso pambuyo pake.

Pambuyo pophunzitsidwa mphamvu za 4, ngakhale panthawi yopumula, mphamvu ya insulini idzakulitsidwa, ndipo kuchuluka kwa shuga (malinga kuti simunadye nawo muyeso) kuchepa. Mukamanyamula katundu kwambiri, zimamveketsa chizindikiritso.

Kutsutsa kwa insulin kumachotsedwa bwino ndi njira yolumikizirana yolimbitsa thupi. Zotsatira zabwino kwambiri ndizojambulidwa ndikusinthana kwa aerobic ndi kulimbitsa mphamvu. Mwachitsanzo, mumapita ku malo ochitira masewera olimbitsa thupi Lolemba, Lachitatu, Lachisanu, ndi Sabata. Chitani Cardio Lolemba ndi Lachisanu (mwachitsanzo, kuthamanga, aerobics, kupalasa njinga), ndikuchita masewera olimbitsa thupi Lachitatu ndi Lamlungu.

Kukana kwa insulini kumatha kukhala kotetezeka ngati kumakula motsutsana ndi maziko a njira monga kutha msinkhu kapena kutenga pakati. Nthawi zina, izi zimawonedwa kuti ndi matenda oopsa a metabolic.

Ndikosavuta kutchula zomwe zimayambitsa matendawa, komabe, anthu onenepa kwambiri amakhudzidwa kwambiri ndi matendawa. Kuchepa kumeneku nthawi zambiri sikuyenda ndi zizindikiro zowoneka bwino.

Ngati sanapatsidwe, kuphwanya kwa insulini kumatha kuyambitsa matenda a shuga komanso matenda osiyanasiyana a mtima. Zochizira kukomoka, mankhwala, zolimbitsa thupi ndi zakudya zapadera zimagwiritsidwa ntchito.

Zomwe zimapangitsa kuti pakhale insulin kukana

Zomwe zimayambitsa kukana insulini sizikudziwika. Amakhulupirira kuti zimatha kubweretsa zovuta zomwe zimachitika pamlingo wambiri: kuchokera pakusintha kwa molekyulu ya insulin komanso kusowa kwa insulin receptors kumavuto ndi kufalikira kwa chizindikiro.

Asayansi ambiri amavomereza kuti chifukwa chachikulu chowonekera cha kukana insulini komanso matenda ashuga ndi kusowa kwa chizindikiro kuchokera ku molekyulu ya insulini kupita ku maselo a minyewa yomwe glucose yochokera m'magazi amayenera kulowa.

Matenda a shuga ndi kupsinjika kudzakhala chinthu chakale

Matenda a shuga ndi omwe amayambitsa pafupifupi 80% yonse yamikwingwirima ndi kuduladula. Anthu 7 mwa anthu 10 amafa chifukwa cha mitsempha ya mtima kapena ubongo. Pafupifupi nthawi zonse, chifukwa chomaliza chomaliza ndi chimodzimodzi - shuga wamwazi.

Shuga akhoza ndipo amayenera kugwetsedwa, apo ayi. Koma izi sizichiritsa matendawa, koma zimangothandiza kulimbana ndi kufufuza, osati zomwe zimayambitsa matendawa.

Mankhwala okhawo omwe amalimbikitsidwa mwalamulo kwa odwala matenda ashuga komanso ogwiritsidwa ntchito ndi endocrinologists pantchito yawo ndi Ji Dao shuga patch.

Kugwiritsa ntchito bwino kwa mankhwalawa, kuwerengera malinga ndi njira yokhazikika (kuchuluka kwa odwala omwe achiwonjezere kuchuluka kwa odwala omwe ali pagulu la anthu 100 omwe adachitiridwa chithandizo):

• Matenda a shuga - 95%
• Kuthetsa kwa mitsempha thrombosis - 70%
• Kuthetsa kwa kugunda kwamtima kwamphamvu - 90%
• Kuthana ndi kuthamanga kwa magazi - 92%
• Kulimbitsa tsiku, kukonza kugona usiku - 97%

Opanga Ji Dao si bungwe lazamalonda ndipo amalipiridwa ndi boma. Chifukwa chake, tsopano wokhala aliyense ali ndi mwayi wopeza mankhwalawo kuchotsera 50%.

Izi zingachitike chifukwa chimodzi kapena zingapo:

1. Kunenepa kwambiri - Amaphatikizidwa ndi insulin kukana mu 75% ya milandu.Ziwerengero zikuwonetsa kuti kuwonjezeka kwa kulemera kwa 40% kuchokera ku chizolowezi kumabweretsa kutsika komweko kwa kutsika kwa chidwi cha insulin. Chiwopsezo china cha kusowa kwa metabolic ndi kunenepa kwambiri kwam'mimba, i.e. pamimba. Chowonadi ndi chakuti minofu ya adipose, yomwe imapangidwa pakhoma lamkati lakumbuyo, imadziwika ndi zochita zapamwamba za metabolic, ndikuchokera kuti kuchuluka kwakukulu kwamafuta acid kumalowa m'magazi.
2. Mitundu - kufalitsa majini okonzeratu ku insulin kukana matenda a shuga ndi matenda a shuga. Ngati achibale apafupi amakhala ndi matenda ashuga, mwayi wokhala ndi zovuta za insulin sensitivity ndiwambiri kwambiri, makamaka ndi moyo womwe simungawutchule wathanzi. Amakhulupirira kuti kukana koyambirira kunapangidwira kuthandiza anthu. Munthawi yokhutitsidwa bwino, anthu amapulumutsa mafuta, mwa anjala - okhawo omwe anali ndi malo ochulukirapo, ndiye kuti, anthu omwe ali ndi insulin kukana, adapulumuka. Zakudya zambiri masiku ano zimabweretsa kunenepa kwambiri, matenda oopsa komanso matenda ashuga.
3. Kulephera kuchita zolimbitsa thupi - kumabweretsa chakuti minofu imafuna zakudya zochepa. Koma ndi minofu yam'mimba yomwe imadya 80% ya shuga kuchokera m'magazi. Ngati maselo am'mimba amafunikira mphamvu zambiri kuti athandizire ntchito zawo zofunika, amayamba kunyalanyaza insulin yomwe imanyamula shuga mwa iwo.
4. M'badwo - Pambuyo zaka 50, kuthekera kwa kukana insulini ndi matenda ashuga ndi 30% kuposa.
5. Chakudya chopatsa thanzi - kudya kwambiri zakudya zopatsa thanzi, kukonda shuga wowonjezera kumayambitsa shuga m'magazi, kupanga insulini mwachangu, chifukwa chake, kusafuna kwa maselo amthupi kuzizindikiritsa, zomwe zimayambitsa matenda a shuga.
6. Mankhwala - Mankhwala ena amatha kuyambitsa matenda kudzera mu insulin - kufala kwa corticosteroids (mphumu

Zizindikiro zake

Popanda kuyesa, ndizosatheka kudziwa kuti maselo amthupi adayamba kuwona bwino kwambiri insulini yomwe idalandiridwa m'magazi. Zizindikiro za kukana insulini zitha kupezeka chifukwa cha matenda ena, kugwira ntchito mopitirira muyeso, zotsatira za kuperewera kwa zakudya m'thupi:

• kulakalaka
• kuzindikira, kuvutika kukumbukira chidziwitso,
• kuchuluka kwa mpweya m'matumbo,
• ulesi ndi kugona tulo, makamaka pambuyo pambiri yodyera,
• kuchuluka kwa mafuta pamimba, mapangidwe a "lifebuoy",
• kukhumudwa, kukhumudwa,
• nthawi ndi nthawi mumatuluka magazi.

Kuphatikiza pazizindikirozi, dokotala amayesa chizindikiro cha kukana insulin asanapange matenda. Wodwala wodwala matendawa amatupa kwambiri pamimba, ali ndi makolo kapena abale ake omwe ali ndi matenda ashuga, azimayi amakhala ndi ovary ya polycystic kapena.

Chizindikiro chachikulu cha kupezeka kwa insulin kukokana ndi kuchuluka kwa m'mimba. Anthu onenepa kwambiri amawunika mtundu wa kunenepa kwambiri. Mtundu wa gynecoid (mafuta amadzaza pansi m'chiuno, kuchuluka kwakukulu m'chiuno ndi matako) ndikotetezeka, zovuta zama metabolic sizichulukana nawo. Mtundu wa Android (mafuta pamimba, mapewa, kumbuyo) umalumikizidwa ndi chiwopsezo chachikulu cha matenda ashuga.

Zolemba za kusokonekera kwa insulin kagayidwe kake ndi BMI ndi chiuno mwa chiuno (OT / V). Ndi BMI> 27, OT / OB> 1 mwaimuna ndi OT / AB> 0,8 mwa mkazi, ndizotheka kwambiri kuti wodwalayo ali ndi insulin resistance syndrome.

Chizindikiro chachitatu, chomwe mwina ndi 90% chimaloleza kukhazikitsa kuphwanya - wakuda acanthosis. Awa ndi madera a khungu lokhala ndi pigmentation yowonjezereka, yomwe nthawi zambiri imakhala yolimba komanso yolimba. Zitha kukhala pamapewa ndi mawondo, kumbuyo kwa khosi, pansi pa chifuwa, pazolumikizana za zala, m'mphepete komanso m'miyendo.

Kuti atsimikizire matendawa, wodwala yemwe ali ndi zizindikiro ndi zolemba pamwambapa amayesedwa kuyesa kwa insulin, kutengera komwe matendawa adatsimikiza.

Kuyesa

Mu Laboratories, kusanthula komwe kumafunikira kuti kudziwa momwe maselo amafunira insulin nthawi zambiri kumatchedwa "Kuunika kwa Insulin Resistance."

Momwe mungaperekere magazi kuti mupeze zotsimikizika:

1. Mukalandira chithandizo kuchokera kwa dokotala yemwe wakupezekerani, kambiranani naye zamndandanda wazamankhwala, njira zakulera komanso mavitamini omwe atengedwa kuti asatenge omwe angakhudze magazi.
2. Tsiku loti lisanachitike, muyenera kuletsa maphunzirowo, yesetsani kupewa zovuta komanso zolimbitsa thupi, osamwa zakumwa zomwe zimakhala ndi mowa. Nthawi ya chakudya chamadzulo iyenera kuwerengedwa kuti isanatenge magazi Maola 8 mpaka 14 apita .
3. Yesetsani mayeso pamimba yopanda kanthu. Izi zikutanthauza kuti m'mawa ndizoletsedwa kutsuka mano, kutafuna chingamu chomwe mulibe shuga, kumwa zakumwa zilizonse, kuphatikizapo zosaphatikizidwa. Mutha kusuta kutatsala ola limodzi kuti ayendere labala .

Izi ndizofunikira pakukonzekera kuwunikiraku chifukwa chakuti kapu yoletsa khofi, itamwa nthawi yolakwika, imatha kusintha kwambiri zowonetsa shuga.

Pambuyo poti kusanthula kwafotokozedwa, ndalamayi yotsutsa insulini imawerengeredwa mu labotale potengera kuchuluka kwa glucose wamagazi ndi kuchuluka kwa insulini m'madzi a m'magazi.

• Dziwani zambiri: - bwanji kutenga malamulowo.

Mimba ndi Insulin Resistance

Kukana kwa insulini kumabweretsa shuga wokwanira wamwazi, yemwe amapangitsa kuti ntchito ya pancreatic iwonjezeke, komanso matenda a shuga. Mlingo wa insulin m'magazi umachuluka, zomwe zimapangitsa kuti minofu ya adipose iwonjezeke. Mafuta ochulukirapo amachepetsa mphamvu ya insulin.

Chosangalatsa ndichakuti kukana insulini panthawi yovomerezeka ndizachilendo, kumakhala kwathupi lathupi. Izi zikufotokozedwa ndikuti glucose ndiye chakudya chachikulu cha mwana wakhanda m'mimba. Nthawi yayitali kwambiri, ndiye kuti pakufunika. Kuchokera pa trimester yachitatu ya shuga, mwana wosabadwayo amayamba kusowa, placenta imaphatikizidwa ndikuwongolera komwe ikuyenda. Imasunga mapuloteni a cytokine, omwe amapereka insulin kukana. Pambuyo pa kubala mwana, chilichonse chimabwerera kumalo ake ndipo zamphamvu za insulin zimabwezeretseka.

Mwa amayi omwe ali ndi thupi lolemera komanso zovuta zapakati, kukana insulini kumatha kupitilira kubereka, zomwe zimawonjezera chiwopsezo chawo cha matenda ashuga.

Doctor of Medical Science, Mutu wa Institute of Diabetesology - Tatyana Yakovleva

Ndakhala ndikuphunzira matenda a shuga kwa zaka zambiri. Zimakhala zowopsa anthu ambiri akamwalira, ndipo makamaka amakhala olumala chifukwa cha matenda ashuga.

Ndithamangira kunena mbiri yabwino - Endocrinological Research Center ya Russian Academy of Medical Sayansi yakwanitsa kupanga mankhwala omwe amachiritsa odwala matenda ashuga mellitus. Pakadali pano, kugwiritsa ntchito bwino kwa mankhwalawa kuyandikira 98%.

Nkhani ina yabwino: Unduna wa Zaumoyo wateteza kukhazikitsidwa kwa pulogalamu yapadera yomwe imalipira mtengo wapamwamba wa mankhwalawa. Ku Russia, odwala matenda ashuga mpaka Epulo 17 (kuphatikiza) nditha kuipeza - Kwa ma ruble 147 okha!

Kodi kuchitira insulin kukana

Zakudya ndi zolimbitsa thupi zimathandiza kuchiza insulin kukana. Nthawi zambiri, zimakhala zokwanira kubwezeretsa chidwi cha maselo. Kuti muchepetse njirayi, nthawi zina amatipatsa mankhwala omwe amatha kuyendetsa kagayidwe.

Chimodzi mwazinthu zomwe zimatsogolera pakupanga matenda a shuga, kupatsirana kwa mtima ndi mapangidwe a magazi ndi insulin kukana. Mutha kuzidziwa nokha mothandizidwa ndi kuyezetsa magazi, zomwe muyenera kuchita pafupipafupi, ndipo ngati mukukayikira matenda, muyenera kuyang'aniridwa ndi dokotala pafupipafupi.

Zizindikiro za matendawa

Katswiri yekha ndi amene angadziwitse za matenda ake potsatira zotsatira za kuwunika ndi kuwona mkhalidwe wa wodwalayo.Koma pali ma alarm angapo angapo omwe thupi limapereka. Palibe chifukwa chomwe anganyalanyazidwe, ndipo mwamsanga ndikofunikira kufunsa dokotala kuti adziwe ngati ali ndi matenda olondola.

Chifukwa chake, pakati pazizindikiro zazikulu za matendawa zimatha kuzindikirika:

• kusokoneza chidwi
• pafupipafupi
• kugona pakudya,
• kusintha kwa kuthamanga kwa magazi, komwe nthawi zambiri kumawona kuchuluka kwa matenda oopsa (kuthamanga kwa magazi),
• kunenepa kwambiri m'chiuno ndi chimodzi mwazizindikiro zazikulu za kukana insulin. Insulin imalepheretsa kuchepa kwa minofu ya adipose, motero ndizosatheka kuchepetsa thupi pazakudya zingapo.
• dziko lokhumudwa
• kuchuluka kwanjala.

Mukadutsa mayeso, zopatuka monga:

• mapuloteni mumkodzo
• kuchuluka triglycerides,
• shuga wamagazi ambiri
• mayeso a cholesterol oyipa.

Mukadutsa kolesterol, ndikofunikira kuti muwunike osayang'ana momwe mukuwonera, koma padera pazolemba za "zabwino" ndi "zoipa".

Chizindikiro chochepa cha cholesterol "chabwino" chitha kuonetsa kukana kwambiri kwa thupi ku insulini.

Mayeso a Insulin Resistance

Kupereka kusanthula kosavuta sikungawonetse chithunzi, mtundu wa insulin umasinthasintha ndipo umasiyanasiyana tsiku lonse. Chizindikiro chabwinobwino ndicho kuchuluka kwa mahomoni m'magazi 3 mpaka 28 mcED / mlngati mayeso aperekedwa pamimba yopanda kanthu. Ndi chisonyezo pamwamba pa chizolowezi, titha kulankhula za hyperinsulinism, ndiko kuti, kuchuluka kwazinthu zambiri za insulin m'magazi, zomwe zimapangitsa kuchepa kwa shuga m'magazi.

Cholondola kwambiri komanso chodalirika ndi kuyesa kwamphepo kapena euglycemic hyperinsulinemic clamp. Sikuti amangotsutsa insulin, komanso azindikiritsa zomwe zimayambitsa matendawa. Komabe, sikuti imagwiritsidwa ntchito pakukonzekera zamankhwala, popeza imawononga nthawi yambiri ndipo imafunikira zida zowonjezera ndi ogwira ntchito ophunzitsidwa bwino.

Insulin Resistance Index (HOMA-IR)

Chizindikiro chake chimagwiritsidwa ntchito ngati njira yowonjezerapo kuti adziwe matendawa. Mlozera umawerengeredwa atatha kuyesa magazi a venous a insulin ndi shuga.

Pakuwerengera, mayeso awiri agwiritsidwa ntchito:

• Indekisi ya IR (HOMA IR) - chizindikirocho ndichabwinobwino, ngati chimakhala chochepera 2.7,
• insulin kukana index (CARO) - ndizachilendo ngati pansipa 0,33.

Kuwerengera kwa indices kumachitika malinga ndi njira:

Pochita izi, taganizirani izi:

• IRI - kusala zolimbitsa thupi insulin,
• GPN - kusala shuga m'magazi.

Mndandanda ukakhala wokwera kuposa momwe amathandizira, kuwonjezeka kwa chitetezo chokwanira m'thupi la insulin kumasonyezedwa.

Kuti muwone zotsatira zowunika bwino, ndikofunikira kusunga malamulo angapo musanafike mpanda wosanthula:

1. Lekani kudya maola 8-12 phunzirolo lisanachitike.
2. Mpanda wowunikira umalimbikitsidwa m'mawa pamimba yopanda kanthu.
3. Mukamamwa mankhwala aliwonse, muyenera kudziwitsa dokotala. Amatha kukhudza kwambiri chithunzi chonse cha kusanthula.
4. Theka la ola musanapereke magazi, simungathe kusuta. Ndikofunika kupewa kupsinjika kwakuthupi komanso mwamalingaliro.

Ngati, mutadutsa mayesowo, zizindikirazo ndizokwera kuposa zabwinobwino, izi zitha kuwonetsa kuwoneka kwa matendawa mthupi monga:

• mtundu 2 shuga
• matenda a mtima, mwachitsanzo, matenda a mtima,
• oncology
• matenda opatsirana
• matenda ashuga
• kunenepa
• polycystic ovary syndrome,
• matenda a adrenal tiziwalo tosiyanasiyana aimpso kulephera,
• aakulu matenda a chiwindi,
• mafuta hepatosis.

Kodi kukana insulin kumatha kuchiritsidwa?

Mpaka pano, palibe malingaliro omveka bwino omwe angachiritse matendawa kwathunthu. Koma pali zida zomwe zimathandiza polimbana ndi matendawa. Izi ndi:

1. Zakudya. Kuchepetsa kudya zamafuta, motero kuchepetsa kutulutsa kwa insulin.
2. Zochita zolimbitsa thupi. Mpaka 80% ya insulin zolandirira zimakhala m'misempha. Kuchita minofu kumalimbikitsa ntchito ya receptor.
3. Kuchepetsa thupi. Malinga ndi asayansi, ndi kuwonda kwambiri 7%, maphunzirowo amatenda bwino kwambiri ndipo kupatsidwa chiyembekezo chokwanira kumaperekedwa.

Dokotala amathanso kutumiza payekhapayekha mankhwala okonzekera wodwala omwe angathandize polimbana ndi kunenepa kwambiri.

Ndi chiwonetsero chowonjezereka cha mahomoni m'magazi, amatsatira zakudya zomwe zimapangidwa kuti zithandizire kukhazikika kwake. Popeza kupanga insulin ndi njira imodzi yothandizira thupi kuwonjezera shuga, munthu sangalole kusinthasintha kwakuthwa kwa shuga m'magazi.

Malamulo oyambira zakudya

• Musachotse mu zakudya zanu zakudya zonse zokhala ndi index yayikulu ya glycemic (ufa wa tirigu, shuga wamafuta, makeke, maswiti ndi zakudya zina). Awa ndi chakudya chamagetsi chomwe chimayambitsa kuthamanga kwa glucose.
• Mukamasankha zakudya zamatumbo, kusankha kumayang'ana pa zakudya zomwe zimakhala ndi index ya glycemic yotsika. Amamezedwa pang'onopang'ono ndi thupi, ndipo glucose amalowa m'magazi pang'onopang'ono. Ndipo zomwe amakonda zimaperekedwa ku zakudya zomwe zimakhala ndi fiber.
• Zakudya zokhala ndi mafuta ambiri okhala ndi polyunsaturated zimayambitsidwa mumenyu, ndipo mafuta odzola amachepetsa. Gwero lotsiriziroli ndi mafuta a masamba - amphaka, maolivi ndi mapeyala. Zosankha zachitsanzo za odwala matenda ashuga.
• Lowetsani zoletsa kugwiritsa ntchito zakudya zamafuta kwambiri (nkhumba, mwanawankhosa, kirimu, batala).
• Nthawi zambiri amatha kuphika nsomba - nsomba, nsomba za pinki, sardine, trout, nsomba. Nsomba ndizopatsa mafuta ambiri a omega-3 acid, zomwe zimapangitsa chidwi cha maselo kupita ku mahomoni.
• Kumverera kwamphamvu kwa njala sikuyenera kuloledwa. Pankhaniyi, shuga ochepa amawonedwa, zomwe zimayambitsa kukula kwa hypoglycemia.
• Idyani m'magawo ang'onoang'ono maola onse awiri ndi atatu.
• Onani makhwala akumwa. Madzi omwe amalimbikitsidwa ndi malita atatu patsiku.
• Kanani zizolowezi zoipa - mowa ndi kusuta. Kusuta kumalepheretsa kagayidwe kachakudya mthupi, ndipo mowa umakhala ndi chidziwitso cha glycemic (zochulukira zakumwa zoledzeretsa -).
• Muyenera kugawanika ndi khofi, chifukwa tiyi wa khofi umathandiza kupanga insulin.
• Mulingo wovomerezeka wamchere umafika mpaka 10 g / tsiku.

Katundu wazakudya za tsiku ndi tsiku

Patebulo liyenera kukhalapo:

• mitundu yosiyanasiyana ya kabichi: broccoli, Brussels zikumera, kolifulawa,
• beets ndi kaloti (kokha owiritsa)
• sipinachi
• saladi
• tsabola wokoma
• nyemba zobiriwira.

• maapulo
• Zipatso za malalanje
• chitumbuwa
• mapeyala
• avocado (werengani nawonso - zabwino za peyala)
• ma apricots
• zipatso.

• tirigu wathunthu ndi wowotchera makeke (onaninso - momwe mungasankhire mkate),
• tirigu
• bulwheat
• oatmeal.

Oimira banja la nyemba:

• mbewu za dzungu, fulakesi, mpendadzuwa.

Mukamasankha malonda, tebulo lotsatirali lithandiza:

Mndandanda wazinthu zololedwa

• nsomba zam'madzi ozizira,
• mazira owiritsa, mafuta othira,
• mafuta amkaka ochepa,
• phala lochokera ku oat, Buckwheat kapena mpunga wa bulauni,
• nkhuku, ndudu zopanda khungu, nyama yopendekera,
• masamba ophika, ophika, owotchera, otentha. Malingaliro pamasamba omwe ali ndi wowuma ayambitsidwa - mbatata, zukini, squash, Yerusalemu artichoke, radish, radish, chimanga,

Mndandanda wazinthu zoletsedwa kwambiri

• shuga, confectionery, chokoleti, maswiti,
• wokondedwa, kupanikizana, kupanikizana,
• masitolo, madzi otentha,
• khofi
• mowa
• buledi wa tirigu, zinthu zophika mkate zopangidwa ndi ufa woyamba
• zipatso zomwe zimakhala ndi wowuma ndi shuga - mphesa, nthochi, masiku, zoumba
• nyama yamitundu yamafuta, ndi yokazinga,

Zogulitsa zina zonse ndizololedwa pang'ono; zakudya zamafuta zimakonzedwa kwa iwo.

Munkhani yotsatira muphunzira mndandanda wazakudya zamagazi zotsitsa odwala matenda ashuga.

Kuphatikiza apo, zowonjezera mchere zimayambitsidwa:

1. Magnesium. Asayansi adachita kafukufuku ndikupeza kuti milingo yokweza ndi glucose m'magazi mwa anthu omwe ali ndi zotsika za chinthuchi, kotero kuchepa kumayenera kudzazidwa.
2. Chrome. Maminolo amathandizira kukula kwa glucose m'magazi, amathandizira kukonza shuga ndikuwotcha mafuta m'thupi.
3. Alpha lipoic acid. Antioxidant yomwe imakulitsa chidwi cha maselo kuti apange insulin.
4. Coenzyme Q10. Ma antioxidant amphamvu.Iyenera kumadyedwa ndi zakudya zamafuta, chifukwa zimamwa kwambiri. Zimathandizira kupewa makutidwe ndi okosijeni a "zoipa" cholesterol komanso kukonza mtima.

Zosankha zachitsanzo za kukana insulini

Pali zosankha zingapo zamakani a insulin. Mwachitsanzo:

• M'mawa umayamba ndi gawo la oatmeal, tchizi chochepa cha kanyumba ndi theka kapu ya zipatso zakutchire.
• Khalani ndi kuluma zipatso.
• Chakudya chamasana chimakhala ndi nkhuku zoyera zoyera kapena nsomba zamafuta. Kumbali yakudyako pali mbale yaying'ono ya Buckwheat kapena nyemba. Watsopano masamba saladi wokometsedwa ndi mafuta, komanso pang'ono sipinachi kapena saladi amadyera.
• Masanawa idyani apulo imodzi.
• Gawo la mpunga wa bulauni, kachidutswa kakang'ono ka nkhuku kapena nsomba, masamba atsopano, omwe amathiridwa ndi batala, amakonzekera chakudya chamadzulo.
• Musanagone, pezani zakudya zingapo kapena ma almond.

Kapena njira ina:

• Chakudya cham'mawa, amaphika phala la mkaka wamtundu wopanda mafuta ndi chidutswa chaching'ono cha batala, tiyi wopanda shuga, osokoneza.
• Kwa nkhomaliro - maapulo ophika.
• Pa nkhomaliro, wiritsani msuzi uliwonse wamasamba kapena msuzi pa msuzi wofooka wa nyama, zodulidwa zodulira, zokongoletsedwa ndi masamba kapena masamba ophika, zipatso.
• Pazakudya zamadzulo, ndikokwanira kumwa kapu ya kefir, yophika mkaka wophika ndi mabisiketi.
• Chakudya chamadzulo - mpunga wakuda ndi nsomba zopangidwa, masamba saladi.

Musaiwale za mndandanda wazinthu zomwe sizingakhale odwala matenda ashuga. Sayenera kudyedwa!

Kukana kwa insulini komanso kutenga pakati

Ngati mayi woyembekezera apezeka ndi insulin, ndikofunikira kutsatira malingaliro onse a dotolo ndikulimbana ndi owonjezera kulemera ndikuwunika zakudya komanso kutsogola moyo wokangalika. Ndikofunikira kusiya ma carbohydrate kwathunthu, kudya mapuloteni ambiri, kuyenda kwambiri ndikuphunzitsira aerobic.

Pakakhala chithandizo choyenera, kukana insulini kungayambitse matenda amtima wamtundu ndi matenda a shuga a 2 mwa mayi woyembekezera.

Chinsinsi cha video cha msuzi wamasamba "Minestrone"

Mu kanema wotsatila, mutha kupeza njira yosavuta yophika masamba, yomwe ingathe kuphatikizidwa menyu yotsutsa insulini:

Ngati mumatsatira kwambiri zakudya, ndikukhala ndi moyo wogwira ntchito, kulemera kumayamba kuchepa, ndipo kuchuluka kwa insulin kudzakhazikika. Zakudya zimapanga zizolowezi zamagulu oyenera kudya, motero, chiopsezo chotenga matenda owopsa kwa anthu - matenda ashuga, matenda a m'matumbo, matenda oopsa komanso mtima

Zomwe zimapatsa thanzi ndi kukana insulin

Ngakhale kuchepa thupi pang'ono kumatha kutsika, kotero malangizo ambiri azakudya amayenera kuchepetsa kuwonda, ngati alipo.

1) Ndikofunikira kuyang'anira kuchuluka kwa chakudya chamagulu. Zakudya zamafuta ochepa, zamafuta kwambiri, zomwe nthawi zambiri zimathandizira kupewa kapena kuchiza matenda a mtima, zitha kuyipitsa. M'malo mwake, chisankho chikuyenera kupangidwa m'malo mwake zakudya zomwe zimakhala ndi chakudya chochepa chamafuta, momwe zimangokhala 40-45% yokha ya zakudya zopatsa mphamvu tsiku lililonse. Kuphatikiza apo, sikofunikira kudya zakudya zilizonse, koma mafuta okhala ndi index yotsika ya glycemic (i.e. omwe amawonjezera shuga pang'onopang'ono). Makonda azikonzedwa mokomera zakudya zotsika mu chakudya komanso zomanga kwambiri.

Izi ndi monga:

• Zamasamba: kabichi, kaloti, broccoli, Brussels zikumera, beets, nyemba zobiriwira, sipinachi, mbatata za jekete, chimanga chokoma, tsabola wokoma.
• : mapeyala, maapulo, ma apulo, malalanje, rasipiberi, mabulosi abulu, mapeyala.
• Mkate, mbewu tirigu wa tirigu, tirigu wathunthu ndi mkate wa rye, oatmeal "Hercules", buckwheat.
• Maembe, mtedza, mbewu: soya, mphodza, nyemba, mbewu za fulakesi, nthanga za maungu ndi nthanga za mpendadzuwa, chinangwa.

2) Mukakhala ndi zochulukirapo, muyenera kudya mafuta onenepa (kuchokera pa 30 mpaka 35% ya zopatsa mphamvu patsiku) kuchokera ku mafuta monga maolivi ndi mafuta ophikira, mtedza ndi mapeyala. Ndipo zakudya monga nyama yamafuta, kirimu, batala, margarine, ndi makeke amafunika kukhala ochepa. Zakudya zamafuta ochepa siziyenera kutsatiridwa, koma mafuta amayenera kukhala athanzi ndikuwadyedwa pang'ono.

Zosakhazikika masamba ndi - ofunikira pakukonzekera chakudya

3) Dokotala akulangizani kuti mudye masamba ambiri osakhazikika: kutumikiridwa kasanu kapena kupitilira patsiku. Sankhani zamasamba osiyanasiyana zomwe zimakhala ndi mitundu yosiyanasiyana. Kuphatikiza apo, ma servings a 2 omwe ali ndi index yotsika ya glycemic, monga ma cherries, mphesa, ma apricots ndi maapulo, ayenera kudya tsiku lililonse.

4) Idyani nsomba zambiri! Sankhani nsomba kuchokera kunyanja yozizira yomwe ili ndi mafuta ochulukirapo a omega-3 acid, monga nsomba, nsomba kapena sardines. Ma Omega-3 acids amathandizira kusintha kwa anti-yotupa monga insulin, komanso kukonza mayankho a maselo ku mahomoni.

5) Idyani pafupipafupi komanso pang'ono. Zakudya izi zimathandiza kukhala ndi shuga m'magazi tsiku lonse, komanso kupewa insulin.

Mavitamini ndi michere yazowonjezera cha

1. Coenzyme Q10(CoQ10). Antioxidant wamphamvu, CoQ10 imalimbikitsa thanzi la mtima poletsa oxidation ya cholesterol yoyipa. Mlingo: 90-120 mg patsiku, wosakanikirana ndi zakudya zamafuta.
2. Alpha lipoic acid. Antioxidant iyi imasintha mayankho a cell ku insulin ndipo imathandizanso kukhazikitsa shuga m'magazi. Mlingo: kuchokera 100 mpaka 400 mg patsiku.
3. Magnesium Mitundu yambiri ya insulini ndi shuga m'magazi nthawi zambiri imawonedwa mwa anthu omwe ali ndi ma protein ochepa a plasma. Ma virnesium othandizira awonetsedwa kuti akuwonjezera kukana kwa insulin m'maphunziro a nyama. Mlingo: 100-400 mg patsiku. Tengani Magnesium Citrate kapena Chelate kapena Glycinate Mage. Osatengera magnesium oxide.
4. Chrome. Mcherewu umathandizira kukhazikitsa shuga m'magazi, umatha kukonza ma seramu lipids, komanso umathandizira kuti thupi lizigwiritsa ntchito bwino glucose ndikuwotcha mafuta. Fomu yabwino kwambiri yogwiritsira ntchito ndi GTF Chromium), mlingo: 1000 mcg patsiku.

Insulin Resistance / Malo A Zaumoyo Dr. Andrew Weil

Chimodzi mwazinthu zomwe zimatsogolera pakupanga matenda a shuga, kupatsirana kwa mtima ndi mapangidwe a magazi ndi insulin kukana. Mutha kuzidziwa nokha mothandizidwa ndi kuyezetsa magazi, zomwe muyenera kuchita pafupipafupi, ndipo ngati mukukayikira matenda, muyenera kuyang'aniridwa ndi dokotala pafupipafupi.

Ndemanga

Idiots, ndipo mumatenga udindo kwa "abambo" omwe, osaganizira kwambiri, amathamangira ku malo ogulitsira mankhwala a ins, kenako adzayamba kufa m'matumba kuchokera ku hypo ?? Kapena masamba mutatha kudya kuti mukhale moyo?

Otsutsa, kodi udawerengapo nkhaniyi?
Si mawu onena za insulin yovomerezeka.

Nkhani yonena za insulin.

Ponena za zoopsa, ndikuvomera. Chaka chilichonse pamakhala zolima zomwe zimafa chifukwa cha hypoglycemia kapena kusintha masamba. Zachidziwikire kuti salemba izi m'manyuzipepala ndipo samawonetsa pa TV.

chilichonse chomwe mungasankhe, kumbukirani kuti kusinthaku sikuyenera kukhalabe komweko kwa miyezi. Pezani insulin masana ndipo mutha kupambana popanda kupewa

Kuti muchepetse kuchuluka kwamafuta, simungathe kudya zakudya zamafuta ndi chisonyezo chambiri cha glycemic mutatha kulimbitsa thupi (kugwira ntchito yayitali), pali mndandanda wazinthu zomwe zili patsamba lino. Ndidzangowonjezera kuti ndisanaphunzitsidwe, ngati mukufuna kuti muchotse mafuta, ndibwino kudya chakudya chamasamba, komanso ndiwo zamasamba zomwe sizikhala ndi wowuma (mukamaphunzitsidwa, mumamva ludzu pang'ono komanso kumadzisangalatsa mosangalala).

Oooh! Tithokoze chifukwa cha kuwola komanso chidziwitso! Ndipo ndimangochita zolakwika.

Superpro , zopatsa mphamvu zamagetsi zomwe zimakhala ndi glycemic index yayikulu sizipangika nthawi yomweyo kuchokera pakulimbitsa thupi, koma m'malo mwake zimafunikira ndikufunika
Koma pali zochepa KOMA!
Ndi uti.
Ndilongosola ndi fanizo: kulemera kwanu = 80 makilogalamu, ndiye magalamu 80 amafuta okhala ndi chisonyezo chachikulu cha glycemic ayenera kubzalidwe "(ngati mumalemera 90 makilogalamu, zikutanthauza 90 magalamu) osawopa nokha. Chimenechi ndicho chiyerekezo chomwe chimafotokozera glycogen wathunthu m'thupi. Izi zimakweza msanga shuga, zomwe zimakhudza zinthu zingapo: zitha kuyimitsanso (kusweka) kwa minofu yotsitsa ndikuchepetsa mphamvu yamahomoni owononga (cartisol ndi adrenaline), ndikupangitsa kuti ayambenso kuchira glycogen nthawi yomweyo. Ndipo komabe (zomwe ine ndekha ndinadabwa ndikamawerenga gwero limodzi) zithandizanso kuyaka kwamafuta. Koma chiwerengerochi sichingathe kupitirira. Popeza owonjezera omwe amapanga othamanga "amayatsidwa" kumbali
Ngati mumamwa Aminka nthawi yomweyo kumapeto kwa kulimbitsa thupi, ndiye kuti insulin ikangotulutsidwa nthawi yomweyo mutamwa mankhwalawa (okhala ndi index yayikulu ya glycemic) ayamba kuwanyamula molunjika kumtunda!

Mafuta okhala ndi index yayikulu ya glycemic (mwachangu) amatsutsana tsiku lonse (kupatula - atangophunzitsidwa nthawi yophunzitsira).
Kulankhula mu Chirasha: ngati wadya chakudya chamagulu am'matumbo am'matumbo, ndiye kuti kuchuluka kwa shuga m'magazi kumangophulika, magazi amayamba kunenepa motero, ndizovuta kupompa magazi okhathamira kumtima kwathunthu. Kenako insulini imamasulidwa kuti muchepetse shuga (m'maso) m'magazi. Ngati kudya kwa (chakudya chofulumira) kunali kolondola pambuyo pa kulimbitsa thupi kapena kumapeto kwa kulimbitsa thupi, ndiye kuti mafuta amthupi othamanga amayamba kusinthika kukhala minofu ndi chiwindi glycogen, ndikuwonjezeranso mbali (ngati mudaposa kuchuluka kovomerezeka. Komano pali lingaliro limodzi apa: mudapereka bwanji zabwino zanu kuntchito) ndiko kuti, kuchuluka kwa glycogen komwe adawononga. Muyenera kuti mudakhala ndi maphunziro obwezeretsa kapena obwereketsa m'njira zonse, ndiye kuti ZINSE ZOFUNIKIRA ZIKUKHALA ZOPANDA BWINO!
Ndipo ngati kudya kwa ma carbohydrate okhala ndi chisonyezo chachikulu cha glycemic kunali masana kutacha kulimbitsa thupi, ndiye kuti amapatsidwanso nthawi yomweyo kumbali zanu ndi mwina 100%. Apa ndipomwe ndikofunikira kudya ma carbohydrate okhala ndi GECEMIC INDEX mkati mwa theka loyamba la tsiku (makamaka m'mawa!). Izi zikuthandizani kukweza shuga m'magazi (kubwezeretsedwanso kwa nthawi yayitali) Pang'onopang'ono, zomwe zingathandize thupi kugwiritsa ntchito mphamvuyi kwakanthawi yayitali (poyerekeza ndi chakudya cham'mimba), potero osapatsa thupi lamulo loti muchepetse shuga ndi magazi kulisunga m'mbali.

PS: zomwe zaperekedwa ndizabwino kwambiri ndipo ZOFUNA! Zowonadi, izi zikuthandizani MU NTHAWI YA "kusinthana ndi switch" kuti muthe kukonzanso kapena kukhazikitsa dongosolo lonse lamphamvu ndi mphamvu popanda kumuvulaza ngati mafuta owonjezera mapaundi.
Zonse zimatengera zolinga zanu, phunzirani kusintha kusinthaku kutengera malingana!