Lantus ndi Levemir - omwe insulin ili bwino komanso momwe mungasinthire wina

Mankhwala Lantus ndi Levemir ali ndi katundu wambiri ndipo ndi mtundu wa insal insulin. Zochita zawo zimapitilira kwakanthawi mthupi la munthu, potero ndikulinganiza kutulutsa kosalekeza kwa timadzi ndi kapamba.

Mankhwala amathandizira odwala ndi ana azaka zopitilira 6 omwe akudwala matenda a shuga.

Kulankhula za Ubwino wa mankhwala amodzi kuposa wina ndikovuta. Kuti mudziwe yani mwa iwo omwe ali ndi katundu wogwira ntchito bwino, ndikofunikira kuganizira iliyonse mwatsatanetsatane.

Lantus imakhala ndi insulin glargine, yomwe ndi analogue ya mahomoni amunthu. Imakhala ndi madzi ochepa osaloŵerera m'ndale. Mankhwalawo pawokha ndi jakisoni wa hypoglycemic wa insulin.

Mankhwala Lantus SoloStar

Mililita imodzi ya jakisoni wa Lantus ili ndi 3.6378 mg wa insulin glargine (100 Units) ndi zina zowonjezera. Makatoni amodzi (mamililita atatu) ali ndi mayunitsi 300. insulin glargine ndi zina zowonjezera.

Mlingo ndi makonzedwe

Mankhwalawa amapangidwira ma subcutaneous makonzedwe; njira ina ingayambitse kwambiri hypoglycemia.

Muli ndi insulin yokhala ndi nthawi yayitali. Mankhwalawa amayenera kuperekedwa kamodzi patsiku nthawi yomweyo.

Panthawi yoikidwiratu komanso munthawi yonse ya chithandizo, ndikofunikira kukhalabe ndi moyo womwe adokotala amathandizira ndikupanga jakisoni pa mlingo wofunikira.

Ndikofunikira kukumbukira kuti Lantus amaletsedwa kusakaniza ndi mankhwala ena.

Mlingo, nthawi ya mankhwala ndi nthawi ya makonzedwe amasankhidwa mankhwalawa aliyense wodwala. Ngakhale kuti kugwiritsa ntchito limodzi ndi mankhwala ena osavomerezeka sikulimbikitsidwa, koma kwa odwala omwe ali ndi matenda a shuga a 2, mankhwalawa atha kupatsidwa mankhwala oteteza pakamwa.

Odwala ena amatha kuchepa kwa insulin:

• odwala okalamba. Mgulu ili la anthu, kusokonezeka kwa impso komwe kumachitika nthawi zambiri kumakhala kofala kwambiri, chifukwa komwe kumakhala kutsika kosafunikira kwa mahomoni,
• odwala ndi mkhutu aimpso ntchito,
• Odwala omwe ali ndi vuto la chiwindi. Gululi la anthu likhoza kukhala ndi chosowa chocheperako chifukwa cha kuchepa kwa gluconeogeneis komanso kuchepa kwa insulin metabolism.

Zotsatira zoyipa

Pogwiritsa ntchito mankhwala Lantus, odwala amatha kukumana ndi zovuta zingapo, zazikulu zomwe ndi hypoglycemia.

Komabe, hypoglycemia siiwo wokhayo, mawonetsedwe otsatirawa ndi othekanso:

• kutsika kwamawonedwe owoneka,
• cholhypertrophy,
• dysgeusia,
• lipoatrophy,
• retinopathy
• urticaria
• bronchospasm
• myalgia
• anaphylactic shock,
• kusungidwa sodium mthupi,
• Edincke's edema,
• hyperemia pamalo jakisoni.

Kumbukirani kuti nthawi zambiri hypoglycemia ikawonongeka, kuwonongeka kwa mitsempha kumatha kuchitika. Hypoglycemia yomwe imakhalapo kwa nthawi yayitali sikuti imangopereka zovuta m'matumbo athunthu, komanso imayambitsa chiopsezo ku moyo wa wodwalayo. Ndi mankhwala a insulin, pali mwayi wodziwonetsa wa ma antibodies a insulin.

Contraindication

Pofuna kupewa zoyipa mthupi, pali malamulo angapo oletsa kugwiritsidwa ntchito ndi odwala:

• M'malo mwake mumakhala tsankho kapena magawo ena othandizira omwe ali mu yankho.
• akudwala hypoglycemia,
• ana ochepera zaka zisanu ndi chimodzi
• mankhwalawa si mankhwala zochizira matenda ashuga ketoacidosis.

Mankhwala amagwiritsidwa ntchito mosamala:

• Ndi kuchepa kwa ziwiya zapamadzi,
• ndi kuchepa kwa ziwiya
• ndi kuchuluka retinopathy,
• odwala omwe amakhala ndi hypoglycemia mu mawonekedwe osawonekera kwa wodwala,
• ndi autonomic neuropathy,
• ndimavuto amisala,
• odwala okalamba
• ndi matenda a shuga
• odwala omwe ali pachiwopsezo cha kudwala hypoglycemia,
• odwala omwe ali ndi chidwi chambiri ndi insulin,
• odwala omwe akuchita zolimbitsa thupi,
• mukamamwa zakumwa zoledzeretsa.

Mankhwalawa ndi analogue ya insulin yamunthu, imakhala ndi zotsatira zokhalitsa. Amagwiritsidwa ntchito ngati insulin yodalira shuga.

Zisonyezero zogwiritsira ntchito ndi mlingo

Mlingo Levemir amayikidwa payekhapayekha. Nthawi zambiri amatengedwa kamodzi kapena kawiri patsiku, poganizira zosowa za wodwalayo.

Pankhani yogwiritsa ntchito mankhwalawa kawiri pa tsiku, jakisoni woyamba amayenera kuperekedwa m'mawa, ndipo wotsatira atatha maola 12.

Popewa kukula kwa lipodystrophy, ndikofunikira kuti musinthe pafupipafupi jekeseni mkati mwa anatomical dera. Mankhwalawa amalowetsedwa mwachangu mu ntchafu.

Mosiyana ndi Lantus, Levemir amatha kutumikiridwa kudzera m'mitsempha, koma izi ziyenera kuyang'aniridwa ndi dokotala.

Zotsatira zoyipa

Panthawi ya mankhwala a Levemir, mavuto osiyanasiyana amatha kuonedwa, ndipo ambiri mwa iwo ndi hypoglycemia.

Kuphatikiza pa hypoglycemia, zotere zimatha kuchitika:

• carbohydrate kagayidwe kachakudya: kusathetseka kwa nkhawa, thukuta, kuwonjezeka, kutopa, kufooka, malo osungika, kuchepa kwa chidwi, kugona mosalekeza, hypoglycemia, mseru, kupweteka kwa mutu, kusanza, kusazindikira, kutsekeka kwa khungu, kusinthika kwa ubongo, imfa,
• kuwonongeka kwamawonekedwe,
• kuphwanya malo a jakisoni: hypersensitivity (redness, kuyabwa, kutupa),
• thupi lawo siligwirizana: zotupa pakhungu, urticaria, pruritus, angioedema, kuvuta kupuma, kuchepa kwa magazi, tachycardia,
• zotumphukira neuropathy.

Momwe mungasinthire kuchokera ku Lantus kupita ku Levemir

Onse a Levemir ndi Lantus amafananizira ndi insulin yaumunthu, yomwe imasiyana pang'ono pakati pawo, yomwe imafotokozedwa pang'onopang'ono.

Wodwala akafunsa momwe angasinthire kuchoka ku Lantus kupita ku Levemir, ndiye kuti ndikulimbikitsidwa kuchita izi moyang'aniridwa ndi dokotala ndikuganizira momwe moyo wa wodwalayo ulili, kuchuluka kapena kuchita zolimbitsa thupi moyenera.

Matenda a shuga ndi njira ya moyo. Matenda aliwonse sangathe. Odwala ali ndi moyo wopitilira ...

Mankhwalawa onse akuimira m'badwo watsopano wa insulin. Onsewa amaperekedwa kwa odwala omwe ali ndi matenda a shuga amtundu woyamba 1, kamodzi pa maola 12-24 kuti akhalebe ndi shuga.

Mankhwalawa amagwiritsidwa ntchito pokhapokha, njira zina zimatha kubweretsa kukomoka kwa glycemic coma.

Pa mankhwalawa, Lantus amaperekedwa mosamala pakanthawi kochepa, amawerengera, popeza mankhwalawa amakhala ndi mphamvu yayitali. Ndi zoletsedwa kusakaniza Lantus ndi mitundu ina ya insulin kapena mankhwala. Therapy iyenera kuchitika molingana ndi malingaliro a madokotala komanso moyang'aniridwa ndi dokotala.

Mawonekedwe

Glargin - insulini, yomwe ndi gawo la Lantus, ndimatsanzira mahomoni aumunthu ndipo amasungunuka pamalo osalolera kwa nthawi yayitali.

Kusagwirizana ndi mankhwala ena sikungaganiziridwe popereka mankhwala kwa odwala omwe ali ndi matenda a shuga 2. Poterepa, ndizotheka kuphatikiza ndimankhwala ena amkamwa.

Milandu yotsika ya insulin yofunika

Kuzindikira kwa shuga - ingomwani tsiku lililonse.

• Matenda aimpso. Nthawi zambiri omwe amapezeka mwa odwala okalamba ndipo ndi chifukwa chakuchepa kwa insulin.
• Odwala omwe ali ndi matenda a chiwindi. Mu gululi la odwala, pali kuchepa kwa gluconeogeneis ndi metabolism ofooka, chifukwa chomwe kufunika kwa mahomoni kumachepa.

Malangizo ogwiritsira ntchito

Mankhwalawa amaperekedwa pang'onopang'ono kwa odwala okulirapo kuposa zaka zisanu ndi chimodzi. Mlingo umodzi umaperekedwa kamodzi pamimba, m'chiuno kapena m'mapewa. Ndikulimbikitsidwa kuti musinthe gawo la ntchito ndikulongosola kulikonse. Mothandizidwa ndi intravenous a mankhwalawo ndi oletsedwa, chifukwa pali chiopsezo chokhala ndi vuto la hypoglycemia.

Mukamasintha kuchokera ku mankhwala ena omwe mumagwiritsa ntchito mankhwala ena othandizira odwala, kusintha kwa chithandizo chofanana, komanso Mlingo wa basal insulin, ndikotheka.

Pofuna kupewa kupezeka kwa hypoglycemia, mlingo umachepetsedwa ndi 30% m'mwezi woyamba wa chithandizo. Munthawi imeneyi, tikulimbikitsidwa kuti muwonjezere mlingo wa insulin yochepa pokhapokha zinthu zikhazikika.

Ndi zoletsedwa kusakaniza kapena kuthira Lantus ndi mankhwala ena. Izi zikuwoneka ngati kusinthika kwa nthawi ya zochita za glargine ndi mapangidwe a zochitika zokhazokha. Nthawi yoyamba yatsopano ya mankhwalawa, ndikofunikira kuwongolera kuchuluka kwa shuga m'magazi.

Lantus ndi Levemir - pali kusiyana kotani?

Lantus ndi Levemir amafanana m'njira zambiri.

Awa ndi mitundu ya insulin ya basal, ndiye kuti, machitidwe awo m'thupi amakhalapo kwa nthawi yayitali, akumawonjezera kutulutsidwa kosalekeza kwa insulin ndi kapamba wama thanzi.

Mankhwala onsewa ndi ma insulin analogi, zomwe zikutanthauza kuti mamolekyu awo a insulin ndi ofanana ndi insulin yaumunthu, kusiyana pang'ono komwe kumachepetsa kuyamwa kwawo.

Lantus - imakhala ndi glargine, mtundu wosinthika wa insulin waumunthu womwe umasungunuka mwapadera. Levemir, m'malo mwa glargine, imakhala ndi detemir, mtundu wina wa insulin yosinthika.

Insulin yaumunthu imakhala ndi maunyolo awiri amino acid (A ndi B), pakati pomwe pali ma cell awiri osagwirizana. Mu glargine, amino acid amachiritsidwanso ndipo ma amino acid ena awiri amawonjezeredwa kumalekezero amto umodzi B. Kusinthaku kumapangitsa kuti glargine isungunuke pa acid acid pH, koma singasungunuke kwambiri pH, yomwe imakonda thupi.

Choyamba, glargine, yomwe ndi gawo la lantus, imapangidwa pogwiritsa ntchito bacteria E. coli. Kenako amayeretsedwa ndikuwonjezeredwa ku yankho lamadzi lomwe lili ndi zinc pang'ono ndi glycerin, hydrochloric acid imawonjezedwanso ku yankho kuti apange pH ya yankho acidic, kotero kuti glargine imasungunuka kwathunthu mumayankho amadzimadzi.

Mankhwalawa atatha kupakidwa minofu yaying'ono, yankho la asidi limasankhidwa kuti likhale pH. Popeza glargine samasungunuka pa pH ya ndale, imakhazikika ndikupanga malo osafunikira mafuta osaneneka.

Kuchokera dziwe kapena malo awa, glargine wokhala ndi mpweya wambiri pang'ono pang'ono umasungunuka, pang'onopang'ono kulowa m'magazi.

Detemir, yomwe ndi gawo la levemir, imapangidwa chifukwa cha ukadaulo wapangiri wa DNA, koma imapangidwa pogwiritsa ntchito yisiti m'malo mwa E. coli.

Levemir ndi yankho lomveka bwino lomwe limaphatikiza kuwonongeka, zinc pang'ono, mannitol, mankhwala ena, ndi hydrochloric acid kapena sodium hydroxide kuti abweretse pH posaloledwa.

Detemir insulin imasiyananso ndi insulin yaumunthu pamapangidwe ake: m'malo mwa amino acid imodzi, yomwe imachotsedwa kumapeto kwa unyolo B, mafuta owonjezera adawonjezeredwa.

Mosiyana ndi glargine, kununkhira sikumapanga chindapusa. M'malo mwake, mphamvu ya kununkhira imapitilira, popeza mawonekedwe ake omwe amasinthidwa amasungidwa kumalo osungirako zinthu zina (pamalo opangira jakisoni), kotero amachedwa.

Pambuyo poti ma molekyulu a detemir atasiyanitsidwa wina ndi mnzake, amalowa mosavuta m'magazi, ndipo mafuta owonjezerawo amamangiriza ku albumin (oposa 98% a magazi omwe amapezeka m'magazi a protein amaphatikizika ndi mapuloteni awa). M'madera otere, insulini imalephera kugwira ntchito.

Popeza detemir imasunthidwa pang'onopang'ono kuchokera ku molekyulu ya albin, imapezeka m'thupi kwa nthawi yayitali.

Ubwino wa lantus pamwamba pa levemirendipo mosinthanitsa ndizotsutsana. Mu maphunziro ena, levemir adawonetsa kuchepa kwa shuga kosasintha komanso kosakhazikika poyerekeza ndi insulin NPH ndi lantus.

Poyerekeza levemir ndi lantus, ndikugwiritsa ntchito mankhwalawa limodzi ndi insulin yofulumira pakati pa odwala omwe ali ndi matenda amtundu wa 1, levemir adawonetsa chiopsezo chochepa cha hypoglycemia ndi nocturnal hypoglycemia, koma chiopsezo chokhala ndi hypoglycemia pakati pa mankhwalawa anali onse, kufananizidwa.

Kuwongolera kwa shuga kwamwazi komwe kunaperekedwa ndi mitundu iwiri ya insulin kunalinso chimodzimodzi.

Kutanthauzira kochokera:https://www.diabeteshealth.com/lantus-and-levemir-whats-the-difference/

Kodi pali kusiyana kotani pakati pa insulin lantus ndi levemir?

Lantus imaphatikizapo glargine, mtundu wosinthika wa insulin waumunthu womwe umasungunuka mwapadera. M'malo mwa glargine, Levemir ili ndi chinyengo, mtundu wina wa insulin yosinthidwa.

Insulin yaumunthu imakhala ndi ma amino acid awiri (A ndi B), omwe amalumikizidwa ndi ma cell awiri a disulfide. Monga gawo la glargine, amino acid imodzi idatengedwa, ndipo ma asidi amino ena awiri adawonjezeredwa kumapeto enawo kwa unyolo wa B. Kusintha kumapangitsa kusungunuka kwa glargine mu pH ya acidic, koma kusungunuka pang'ono mu pH yosagwirizana, yomwe imadziwika ndi thupi laumunthu.

Mankhwalawa atatha kupakidwa minofu yaying'ono, acidic solution imakanthidwa ndi thupi kupita pH. Popeza glargine samatha kulowerera pH, imatulutsa, yomwe imapangika malo osafunikira mu mafuta osunthika. Kuchokera dziwe kapena malo awa, glargine wokhala ndi mpweya wambiri pang'ono pang'ono umasungunuka, pang'ono ndi pang'ono kulowa m'magazi.

Tekinoloje ya Recombinant DNA imagwiritsidwanso ntchito popanga chinyengo, chomwe chimagwiritsidwa ntchito ngati gawo la Levemir, koma chimapangidwa pogwiritsa ntchito yisiti bowa, osati mabakiteriya a E coli.

Kupanga kwa Levemir, komwe ndi njira yowonekera, kuwonjezera pa insulin kumaphatikizanso zinc pang'ono, mannitol, mankhwala ena, hydrochloric acid kapena sodium hydroxide, yomwe imagwiritsidwa ntchito pH pH posakhala mbali.

Detemir insulin imasiyananso ndi insulin ya anthu chifukwa chakuti amino acid imodzi imachotsedwa kumapeto kwa unyolo B ndipo mafuta ena adamuwonjezera.

Kuposa 98% ya kunyansidwa m'magazi kumakhala ndi albin. M'madera otere, insulini imalephera kugwira ntchito. Popeza detemir imasungidwa pang'onopang'ono kuchokera ku molekyulu ya albin, imapezeka m'thupi kwakanthawi.

Ku funso loti ndi liti, Lantus kapena Levemir, yankho silikhala lomveka. Levemir nthawi zambiri amalimbikitsidwa kuti azithandizidwa kawiri tsiku lililonse (ngakhale FDA idavomerezedwa kuti iziyang'anira limodzi), ndi Lantus kamodzi patsiku.

Malinga ndi adotolo, Richard Bernstein, ndikuwonetsa Lantus kawiri patsiku, ntchito yake imayenda bwino. Chikhalidwe cha acidic cha Lantus nthawi zina chimatha kuyambitsa kutentha kwa malo a jakisoni.

Mankhwala onse awiriwa amatha kukhala omwe amachititsa kuti anthu azigwirizana.

M'maphunziro ena, Levemir adawonetsa kusakhazikika kwakanthawi komanso kumachepetsa shuga poyerekeza ndi insulin NPH ndi Lantus.

Poyerekeza Levemir ndi Lantus, ndikugwiritsa ntchito mankhwalawa limodzi ndi insulin yothamanga odwala omwe ali ndi matenda amtundu wa 1, Levemir adawonetsa mwayi wochepetsedwa ndi hypoglycemia yausiku, komabe, chiopsezo chokhala ndi hypoglycemia pakati pa mankhwalawa nthawi zambiri chimafanana.Mulingo wa shuga wamagazi, womwe umayendetsedwa ndi ntchito ya mitundu iwiri ya insulin, nawonso unali wofanana.

Tujeo SoloStar yowonjezera Insulin Dose Kuwerengetsa Algorithm - Chitsanzo Chabwino

Choyamba, m'bale wanu ali ndi chipepeso chochepa cha shuga, chifukwa kuyambira 7 mpaka 11 mmol / l - awa ndi mashuga ambiri, omwe amatsogolera ku zovuta za matenda ashuga. Chifukwa chake, kusankha kwa kuchuluka kwa insulin yowonjezera kumafunika. Simunalembe nthawi yanji ya tsiku lomwe ali ndi shuga 5 mmol / l, ndipo akwera mpaka 10-11 mmol / l?

Basal Insulin Tujeo SoloStar (Toujeo)

Insulin yowonjezera Toujeo SoloStar (Toujeo) - gulu latsopano la kampani ya Sanofi, yomwe imatulutsa Lantus. Kutalika kwa kuchitapo kwake ndikutali kuposa kwa Lantus - kumatenga maola 24 (mpaka maola 35) poyerekeza ndi maola 24 a Lantus.

Insulin Tozheo SoloStar likupezeka mu ndende yayikulu kuposa Lantus (mayunitsi 300 / ml motsutsana ndi mayunitsi 100 / ml a Lantus). Koma malangizo ake ogwiritsira ntchito akuti mlingo uyenera kukhala wofanana ndi wa Lantus, umodzi mpaka umodzi. Ndikungokhala kuti kuchuluka kwa ma insulin awa ndi kosiyana, koma makulidwe m'zowunikira amakhalabe chomwecho.

Poyerekeza ndemanga ya odwala matenda ashuga, Tujeo amachita zinthu zosasangalatsa komanso wamphamvu kuposa Lantus, ngati mungayike muyezo womwewo. Chonde dziwani kuti zimatenga masiku 3-5 kuti Tujeo achite zinthu mokwanira (izi zikugwiranso ntchito kwa Lantus - zimatenga nthawi kuti zizolowere insulin yatsopano). Chifukwa chake, kuyeserera, ngati kuli kotheka, muchepetseni.

Ndilinso ndi matenda a shuga 1, ndimagwiritsa ntchito Levemir monga basal insulin. Ndili ndi pafupifupi mlingo womwewo - ndimayika mayunitsi 14 nthawi ya 12 masana ndi maola 15-24 maola 15 magawo.

Algorithm yowerengera kuchuluka kwa insulin Tujeo SoloStar (Levemira, Lantus)

Muyenera kucheza ndi wachibale wanu kuwerengedwa kwa kuchuluka kwa insulin yomwe akufuna. Izi zimachitika motere:

1. Tiyeni tiyambe kuwerengera mlingo wamadzulo. Mbale wanu adye monga mwa nthawi zonse ndipo asadyerenso tsiku lomwelo. Izi ndizofunikira kuchotsa ma surges mu shuga omwe amayamba chifukwa chodya ndi insulin yochepa. Pena kuyambira 18-00 amayamba maola 1.5 aliwonse kuti amweze magazi. Palibenso chifukwa chodyera chakudya chamadzulo. Ngati ndi kotheka, ikani insulini yaying'ono kuti shuga ikhale yabwinobwino.
2. Pofika 22 koloko tengani mankhwala a insulin ambiri. Mukamagwiritsa ntchito Toujeo SoloStar 300, ndimalimbikitsa kuyamba ndi magawo 15. Maola 2 mutatha jakisoni, yambani kumwa miyezo ya shuga ya magazi. Sungani chojambulira - lembani nthawi ya jakisoni ndi zizindikiro za glycemia. Pali chiopsezo cha hypoglycemia, kotero muyenera kusunga china chokoma - tiyi wotentha, msuzi wokoma, ma cubes a shuga, mapiritsi a Dextro4, etc.
3. Peak basal insulini iyenera kubwera pafupifupi cha m'ma a.m., choncho khalani maso. Miyeso ya shuga imatha kupangidwa ola lililonse.
4. Chifukwa chake, mutha kuyang'anira mphamvu yamadzulo (usiku) Mlingo wa insulin yowonjezera. Ngati shuga amachepetsa usiku, ndiye kuti mankhwalawo ayenera kuchepetsedwa ndi 1 unit ndikubweretsanso kafukufuku womwe. Mosiyana, ngati shuga amakwera, ndiye kuti kuchuluka kwa Toujeo SoloStar 300 kuyenera kuwonjezeka pang'ono.
5. Momwemonso, yesani m'mawa mlingo wa basal insulin. Bwino osati pompopompo - yambani ndi kumwa kwa mankhwalawa, kenako musinthe tsiku lililonse.

Mukamawerengera insulin ya basal maola 1-1,5 alionse, kuyeza shuga

Monga zitsanzo zenizeni, ndipereka diary yanga posankha mtundu wa basal insulin Levemir (wogwiritsa ntchito mlingo wam'mawa mwachitsanzo):

Nthawi 7 koloko amayambitsa magulu 14 a Levemir. Sanadye chakudya cham'mawa.

Kuchokera pagome kumatha kuwoneka kuti ndinatenga mlingo woyenera wa insulin yayitali, chifukwa shuga imasungidwa pafupifupi chimodzimodzi. Ngati atayamba kuchuluka kuchokera pa maola pafupifupi 10-12, ndiye kuti ichi chizikhala chizowonjezera. Ndipo mosemphanitsa.

Levemir: malangizo ogwiritsira ntchito. Momwe mungasankhire mlingo. Ndemanga

Insulin Levemir (detemir): phunzirani zonse zomwe mukufuna. Pansipa mupeza malangizo atsatanetsatane ogwiritsira ntchito olembedwa mchilankhulo. Dziwani:

Levemir ndi insulin yowonjezera (basal), yomwe imapangidwa ndi kampani yotchuka komanso yolemekezeka yapadziko lonse Novo Nordisk. Mankhwalawa agwiritsidwa ntchito kuyambira m'ma 2000s. Anakwanitsa kutchuka pakati pa odwala matenda ashuga, ngakhale insulin Lantus ili ndi gawo lalikulu pamsika. Werengani ndemanga zenizeni za odwala omwe ali ndi matenda amtundu wa 2 komanso matenda amitundu iwiri, komanso zomwe ana angagwiritse ntchito.

Komanso phunzirani zamankhwala othandizira omwe amasunga magazi anu kukhala 3.9-5,5 mmol / L khola maola 24 patsiku, monga momwe mungakhalire ndi anthu athanzi. Dongosolo la Dr. Bernstein, amene akhala ndi matenda ashuga kwa zaka zopitilira 70, amalola akuluakulu ndi ana odwala matenda ashuga kudziteteza ku zovuta zowopsa.

Long insulin levemir: Nkhani zatsatanetsatane

Chidwi chachikulu chimaperekedwa polamulira matenda ashuga. Levemir ndi mankhwala osankhidwa kwa amayi apakati omwe ali ndi shuga wambiri. Kafukufuku wovuta watsimikizira chitetezo chake komanso kugwira ntchito bwino kwa amayi oyembekezera, komanso kwa ana kuyambira zaka ziwiri.

Kumbukirani kuti insulin yowonongeka imakhala yowoneka bwino kwambiri. Ubwino wa mankhwalawa sungadziwike ndi maonekedwe ake. Chifukwa chake, sikofunikira kugula Levemir kuchokera m'manja, malinga ndi kulengeza kwapadera. Gulani mumasitolo akuluakulu odziwika omwe antchito ake amadziwa malamulo osungira ndipo si aulesi kwambiri kuti athe kutsatira.

Kodi levemir ndi insulini ya chochita? Kodi ndizitali kapena zazifupi?

Levemir ndi insulin wa nthawi yayitali. Mlingo uliwonse womwe umaperekedwa umachepetsa shuga mkati mwa maola 18-24. Komabe, odwala matenda ashuga omwe amatsata zakudya zama carb ochepa amafunika Mlingo wochepetsetsa, 2-8 nthawi yotsika kuposa omwe amakhala.

Pogwiritsa ntchito mankhwalawa, mphamvu ya mankhwalawa imatha mofulumira, mkati mwa maola 10-16. Mosiyana ndi wastani insulin Protafan, Levemir alibe chiwonetsero chokwanira kuchitapo kanthu.

Samalani ndi mankhwala atsopano a Tresib, omwe amakhala nthawi yayitali, mpaka maola 42, komanso bwino.

Levemir si inshuwaransi yayifupi. Sikoyenera malo omwe muyenera kuthana ndi shuga msanga. Komanso, siyenera kunenedwa musanadye chakudya kuti mugwirizane ndi chakudya chomwe odwala matenda ashuga akukonzekera kudya. Pazifukwa izi, kukonzekera kwakanthawi kapena ultrashort kumagwiritsidwa ntchito. Werengani nkhani yakuti “Mitundu ya Insulin ndi Zotsatira Zawo” mwatsatanetsatane.

Onerani kanema wa Dr. Bernstein. Dziwani chifukwa chake Levemir ali bwino kuposa Lantus. Mvetsetsani kangati patsiku muyenera kulidulira ilo komanso nthawi yanji. Onani kuti mukusunga insulini yanu molondola kuti isawonongeke.

Momwe mungasankhire mlingo?

Mlingo wa Levemir ndi mitundu ina yonse ya insulin uyenera kusankhidwa payekhapayekha. Kwa odwala matenda ashuga akuluakulu, pali malingaliro oyambira kuti ayambe ndi 10 PIECES kapena 0,1-0.2 PIECES / kg.

Komabe, kwa odwala omwe amatsata zakudya zama carb otsika kwambiri, mankhwalawa azikhala okwera kwambiri. Onani shuga wanu wamagazi masiku angapo. Sankhani mulingo woyenera wa insulin pogwiritsa ntchito zomwe mwalandira.

Werengani zambiri mu nkhani "Kuwerengera Mlingo wa insulin yayitali usiku ndi m'mawa."

Kodi mankhwalawa amafunika kuti alowetse ndani mwa mwana wazaka 3?

Zimatengera zakudya zamtundu wanji mwana wodwala matenda ashuga. Ngati adasinthidwa kudya zakudya zama carb ochepa, ndiye kuti Mlingo wochepetsetsa kwambiri, ngati homeopathic, ungafunike.

Mwinanso, muyenera kulowa ku Levemir m'mawa ndi madzulo muzinthu zosaposa 1 unit. Mutha kuyamba ndi mayunitsi 0,25. Kuti mupeze jekeseni yotsika bwino, ndikofunikira kuthira njira yofayira jakisoni.

Werengani zambiri za izo apa.

Pakazizira, poizoni wa chakudya ndi matenda ena opatsirana, Mlingo wa insulin uyenera kuchuluka nthawi 1.5. Chonde dziwani kuti kukonzekera kwa Lantus, Tujeo ndi Tresiba sikungathe kuchepetsedwa.

Chifukwa chake, kwa ana aang'ono a mitundu yayitali ya insulin, ndi Levemir ndi Protafan yekhayo amene atsalira. Phunzirani nkhani ya “Matenda a Ana A shuga.”

Phunzirani momwe mungatalikitsire nthawi yanu ya tchuthi ndikukhazikitsa mtundu wabwino wama shuga.

Mitundu ya insulini: Momwe mungasankhire mankhwala a insulin yayitali usiku ndi m'mawa Muwerengera kuchuluka kwa insulin musanadye chakudya

Momwe mungasinthire Levemir? Kangati patsiku?

Levemir sikokwanira kumangodula kamodzi patsiku. Iyenera kuperekedwa kawiri pa tsiku - m'mawa ndi usiku. Kuphatikiza apo, zochita zamankhwala a madzulo nthawi zambiri sizikhala zokwanira usiku wonse. Chifukwa cha izi, odwala matenda ashuga amatha kukhala ndi zovuta zam'mawa m'mimba yopanda kanthu. Werengani nkhani yoti "Shuga pamimba yopanda kanthu m'mawa: momwe mungabwezeretsere zodabwitsa". Komanso werengani za "insulin management: momwe ndi momwe mungabayitsire".

Kodi mankhwalawa angafanane ndi Protafan?

Levemir ndi wabwino kwambiri kuposa Protafan. Majekeseni a insulin a Protafan satenga nthawi yayitali, makamaka ngati milingo yotsika. Mankhwalawa amakhala ndi puloteni wa nyama, zomwe nthawi zambiri zimayambitsa matupi awo.

Ndikwabwino kukana kugwiritsa ntchito protafan insulin. Ngakhale mankhwalawa akaperekedwa kwaulere, ndipo mitundu ina ya insulin yowonjezera idzayenera kugulidwa ndi ndalama. Pitani ku Levemir, Lantus kapena Tresiba.

Werengani zambiri mu nkhani "Mitundu ya Insulin ndi Zotsatira Zawo".

Levemir Penfill ndi Flekspen: Kusiyana kwake ndi kotani?

Flekspen ndi cholembera chimbale momwe mavekitala a inshuwaransi ya Levemir amaikiramo.

Penfill ndi mankhwala a Levemir omwe amagulitsidwa popanda zolembera kuti mugwiritse ntchito syringes yokhazikika ya insulin. Ma cholembera a Flexspen ali ndi gawo la 1 unit.

Izi zitha kukhala zosokoneza mankhwalawa a shuga kwa ana omwe amafunikira kuchuluka. Zikatero, ndikofunika kupeza ndikugwiritsa ntchito Penfill.

Levemir alibe ma analogu otsika mtengo. Chifukwa mawonekedwe ake amatetezedwa ndi patent yomwe kuvomerezeka kwake sikunathe. Pali mitundu ingapo yofanana ya insulin yayitali kuchokera kwa opanga ena. Awa ndi mankhwala Lantus, Tujeo ndi Tresiba.

Mutha kuphunzira mwatsatanetsatane nkhani iliyonse. Komabe, mankhwalawa onse siotsika mtengo. Insulin-average insulin, monga Protafan, imakhala yotsika mtengo. Komabe, zili ndi zolakwika zazikulu chifukwa chake Dr. Bernstein ndi tsamba la odwala endocrin.

com sikulimbikitsa kugwiritsa ntchito.

Levemir kapena Lantus: ndi insulin iti bwino?

Yankho lachilendo la funsoli laperekedwa munkhaniyi ya insulin Lantus. Ngati Levemir kapena Lantus akukwiyirani, pitilizani kugwiritsa ntchito. Musasinthe mankhwala amitundu ina pokhapokha ngati pakufunika kutero.

Ngati mukukonzekera kuyamba kubayitsa insulin yayitali, ndiye yesetsani Levemir. Insulin yatsopano ya Treshiba ndiyabwino kuposa Levemir ndi Lantus, chifukwa imatenga nthawi yayitali komanso bwino.

Komabe, zimawononga pafupifupi katatu katatu.

Levemir pa mimba

Kafukufuku wamkulu wazachipatala adachitidwa omwe adatsimikizira chitetezo ndi kuyendetsa bwino kwa kayendetsedwe ka Levemir pa nthawi yapakati.

Mitundu yampikisano ya insulin Lantus, Tujeo ndi Tresiba sangadzitame chifukwa cha umboni wabwino wotetezedwa.

Ndikofunika kuti mayi woyembekezera yemwe ali ndi shuga wambiri amvetsetse momwe angawerengere Mlingo woyenera.

Insulin siyowopsa kwa mayi kapena kwa mwana wosabadwayo, malinga ngati mankhwalawo asankhidwa molondola. Matenda a shuga oyembekezera, ngati atasiyidwa, amatha kubweretsa mavuto akulu. Chifukwa chake, lembani molimba mtima Levemir ngati dokotala wakuuzani kuti muchite izi. Yesani kuchita popanda kulandira insulin, kutsatira zakudya zabwino. Werengani nkhani zakuti “Amayi Azipakati” ndi “Gestational Diabetes” kuti mumve zambiri.

Levemir wakhala akugwiritsidwa ntchito kuwongolera matenda a shuga a 2 ndikulemba mtundu 1 kuyambira m'ma 2000s. Ngakhale mankhwalawa ali ndi mafani ocheperako kuposa a Lantus, ndemanga zokwanira zasonkhana pazaka zambiri. Ambiri mwaiwo ndi abwino. Odwala amati insulin imachepetsa shuga m'magazi. Nthawi yomweyo, chiopsezo cha hypoglycemia ndichochepa kwambiri.

Gawo lalikulu la ndemanga zalembedwa ndi azimayi omwe amagwiritsa ntchito Levemir pa nthawi yoyembekezera kuti athe kuthana ndi matenda ashuga. Kwenikweni, odwala awa amakhutira ndi mankhwalawo. Sichosokoneza, jakisoni wobala mwana atatha kuthetsedwa popanda mavuto. Kulondola ndikofunikira kuti musapange cholakwika ndi mlingo, koma ndi kukonzekera kwina kwa insulin ndizofanana.

Malinga ndi odwala, chododometsa chachikulu ndikuti cartridge yoyambira iyenera kugwiritsidwa ntchito mkati mwa masiku 30. Ino ndi nthawi yochepa kwambiri. Nthawi zambiri mumayenera kutaya ndalama zonse zosagwiritsidwa ntchito, ndipo pambuyo pake, ndalama zawalipira. Koma mankhwala onse opikisana ali ndi vuto lomweli. Ndemanga za odwala matenda ashuga zimatsimikizira kuti Levemir ndiwopambana ndi pafupifupi insulin Protafan pazinthu zonse zofunika.

Kusintha kuchokera ku Levemir kupita ku Treshiba: zokumana nazo zathu

Kuyambira pa chiyambi pomwe, ndinapitiriza Treshibou ziyembekezo zapamwamba. Popita nthawi, Levemir adayamba kutikhumudwitsa, ndipo mwachangu kwambiri ndidathamangira kukagula Treshiba. Ndiyenera kunena nthawi yomweyo kuti popanda kuwunikira kosalekeza, sindingakhale pachiwopsezo chokha kusintha insulin yanga.

Kuphatikiza apo, mankhwalawa ndi achilendo ndipo madotolo sanapeze chidziwitso chokwanira pakugwiritsa ntchito, chifukwa chake ndimamva ngati mpainiya weniweni. Ndiyenera kunena nthawi yomweyo kuti chiyambi sichinali cholimbikitsa kwambiri.

Panthawi inayake, ndidakhala ndi nkhawa ndikufika mpaka pomwe ndidayitanira NovoNordisk kuti ndikafunse. Madotolo, omwe ndimakonda kulumikizana nawo, adanditsatira modekha mayeso ndi njira zolakwika mpaka pamapeto pake ndizotheka kuwunika mozama.

Ndipo tsopano, zitatha miyezi itatu yogwiritsa ntchito Tciousba Ndinaganiza kugawana zomwe takumana nazo ndi malingaliro ena.

Kupita ku Treshiba: koyamba?

Mlingo woyambira ndi funso lalikulu. Monga lamulo, Tresiba ndiyotchuka chifukwa cha mphamvu zake zapamwamba, chifukwa chake, Mlingo wake, poyerekeza ndi insulin zina zam'mbuyo, umachepetsedwa kwambiri. Pa upangiri wa dokotala, tinayamba ndi kumwa kuti 30% yochepa kuposa kuchuluka kwa tsiku lililonse Levemira.

Panthawiyo, levemire yonse inali pafupifupi magawo 8-9. Jakisoni woyamba tinapanga mayunitsi 6. Ndipo usiku woyamba iwo adakhudzidwa ndi izi: dongosolo la shuga usiku limafanana ndi mzere pansi pathanthwe pang'ono.

M'mawa ndimayenera kumwa madzi a mwana, koma chithunzi chosalala chotere chidandigometsa. Ku Levemir, mulingo uliwonse, shuga usiku amayenda ndi ife momwe amakondera: amatha kuwuka kupita ku 15 kenako amabwerera kwazonse. Mwachidule, panali njira zambiri, koma sizinachitike popanda kusiyana.

Ndinalimbikitsidwa kwambiri. Koma kenako zonse sizinakhale zophweka monga momwe zimawonekera poyamba.

Kuyambira tsiku lotsatira, tinayamba kuchepetsa mwadongosolo mlingo, koma sitinathe kuwunika mwachangu zotsatira zake. Chowonadi ndi chakuti khadi yayikulu ya lipenga ya Treshiba, nthawi yake yopambana, pamagawo oyamba sakukondera.

Ndiye kuti mumapereka jakisoni, masana mumayesa kuchuluka kwa shuga, tsiku lotsatira muyenera kusankha zosintha pa mlingo, koma simudzakhoza kuyambira tsiku loyambika.

Chowonadi ndi chakuti mchira wa Treshiba kuyambira tsiku lapitalo umakupatsani insulin yokwanira kwa maola osachepera 10, kuchokera pamenepo, sizowopsa kuti mupeze kuchuluka kwa mlingo wochepetsera. Sabata yoyamba tidangochita kuti tidachepetsa mulingo ndikuthirira mwana ndi madzi. Koma sanataye mtima.

Zinatitenga pafupi milungu iwiri kapena itatu kukhazikitsa mlingo woyenera. Pankhaniyi, tiyenera kukumbukira kuti mutha kusangalala mokwanira ndi "kubedwa mfuti" ku Treshiba patadutsa masiku 3-4 atakhala kuti akhazikika.

Ndiye kuti, mpaka mlingo woyenera utasankhidwa, kukhazikika kungangolokedwa. Koma mutapanga "insulin depot" yomweyo, mutha kumasuka.

Zotsatira zake, mlingo wathu wogwira wa Treshiba unadzakhala theka la pafupifupi tsiku lililonse la Levemir.

Kuteteza nthawi

Ntchito ina yomwe muyenera kudzithetsa ndikusankha ngati kuli koyenera kuyesa Treshib: m'mawa kapena madzulo. Madokotala mwachikhalidwe amalimbikitsa kuyambira ndi jakisoni wamadzulo. Pali malongosoledwe angapo a njira imeneyi. Choyamba, amakhulupirira kuti insulini yakumbuyo iyenera kuwunika moyenera usiku, yopanda kususuka ndi insulin ya chakudya.

Inde, usiku ndi malo oyeserera oyeserera a insulin, mwachidziwikire, atha kuyang'aniridwa nthawi zonse. Popanda izi, sindikadaganiza zoyeserera zotere, chifukwa panali zochitika zina pomwe usiku umodzi ndimapatsa mwana wanga kangapo madzi.

Kachiwiri, zitha kuganiziridwa kuti ndizotetezeka: usiku, insulini idzayamba kuchitika bwino kuti ikwaniritse inu chakudya cham'mawa. Motsogozedwa ndi mfundozi, tidayamba kumayankhula Treshiba asanagone. Koma njirayi inali yovuta kwambiri. Usiku, shuga nthawi zambiri ankakonda kuphuka kapena amangofunafuna poyera, ndipo masana sanali okwanira.

Pomaliza kuyesa kwathu, tinali okonzeka kuvomereza kugonjetsedwa kwathunthu ndi nyimbo zam'mbuyo, ndiko kuti tibwerere ku Levemir yakale yotsimikiziridwa. Koma zonse zidasankhidwa mwamwayi.

Atakambirana ndi adotolo, adaganiza zopereka tsiku kuti Treshiba "atheretu", kenako m'mawa ndi mphamvu prick Levemir. Ndipo chozizwitsa chidachitika.

Usiku womwe, womwe umakhala mchira wa Treshiba kuyambira tsiku latha, unali wovuta kwambiri m'mbiri yathu yaposachedwa. Chithunzi chomwe chinali polojekiti inali mzere umodzi wowongoka - nthawi zambiri popanda kukaikira. M'mawa tinayenera kusankha: kumenya Levemir kapena kupatsa Treshiba mwayi wachiwiri.

Tinasankha lachiwiri ndipo silinataye. Kuyambira tsikulo tinayamba kuyambitsa Treshiba m'mawa tisanadye chakudya cham'mawa, ndipo mtundu woterewu unakhala wabwino kwa ife.

Zotsatira za Treshiba (miyezi 3)

1) Chimasunga maziko kwambiri ndipo chimakhala chamtsogolo. Mosiyana ndi Levemir, munthu sayenera kulosera pamene insulin ya basal inayamba kugwira ntchito, ikafika pachimake, komanso ngati idapuma pantchito. Palibe mawanga oyera. Mbiri yolimba yomwe yaseweredwa nthawi yayitali. Ku Levemir, tinali ndi mavuto usana ndi usiku.

Kuyambira zikande (zopanda chakudya kapena mchiuno) shuga amangokwera pamwamba. Zinali zokhumudwitsa kwambiri. Treshiba adathetsa funso lapa nthawi yamasana. Palibe zodandaula. Koma usiku kwa ife akadali mayeso: mwina kukwera kwa shuga, kapena kutuwa. Nthawi zina, timatha kugona tulo. Koma pazonse, zinthu ku Tresib zakhala bwino kwambiri.

2) Inemwini, ndikuyambitsa konse, ndimakonda chowombera cham'mbuyo kwambiri kamodzi patsiku. Kodi ndikupitilizabe kuwunikira momwe zinthu zikuyendera.

Ndipo m'mbuyomu, nthawi iliyonse ndimayenera kudziwa zomwe zikuyenda ndi kuti, kenako ndikusankha kuti ndiziwonjezera pati m'mawa ndi madzulo. Wina, m'malo mwake, amakonda kusinthasintha kwa magawo awiri omwe Levemir amapereka.

Koma sitinapeze zophweka ku kusinthaku ndipo sitinawonjezere kumveka. Ngakhale, zowona, sizinali zophweka panthawi yosankha mlingo, chifukwa Tresiba adachotsedwa nthawi yayitali.

3) Tresiba imakwaniritsa muyezo Novopen amagwira ndizowonjezera za 0,5. Izi ndizofunikira kwambiri, chifukwa kwa ana zimawonekera kwambiri.

Kwa Lantus, kulibe zolembera zoyambirira zomwe zili ndi theka, koma njira yamisiri, amisiri ambiri amaisokosera ngati zolembera zakunja.

Pankhaniyi, monga momwe ndikudziwira, izi zimachitika ndikutayika kwa insulin (muyenera kupopera ziwerengero zingapo).

1) Kuphatikizika kwakukulu kwa Treshiba ndi mbali yotsatsira. Malo okhala ndi insulin, zokutira zapamwamba zimagwira ntchito kwa inu komanso motsutsana ndi inu. Ngati china chake chasokonekera ndi jakisoni, palibe choti chichitike, mudzatupa mpaka masiku awiri.

Ngakhale ndi kuchepetsedwa kwa mlingo, kufunika kwake sikungachitike mwachangu chifukwa cha machitidwe a michira ya Treshibachimakwirira tsiku lotsatira. Chifukwa chake, ndikafuna kuchepetsa mankhwalawa tsiku lotsatira, ndimachepetsa mwachangu magawo 1-1,5, nditapatsidwa kuti mchira kuyambira tsiku lathalo udzaphimba zosowa.

Koma awa ndi mabodza anga enieni omwe sagwirizana ndi mankhwala ovomerezeka. Chifukwa chake, monga akunenera, musayese kubwereza nokha - ndibwino kuti mutembenukire kwa akatswiri.

2) Mtengo chimalepheretsa chachikulu. Komabe, iyi ndi nkhani ya nthawi, popeza Treshibu adalembedwa kale mndandanda wamankhwala osangalatsa a shuga ndipo adzapatsidwa malinga ndi maphikidwe aulere. Mwachitsanzo, ife tidalonjezedwa naye Chaka Chatsopano.

Mwambiri, ndinganene kuti ndife okhutira ndi Tresiba. Ngakhale kwa ife kuyesaku ndi malo opitilira njira yopita pampu. Takhala tikuchita bwino ndi insulin, koma tili ndi maziko okhazikika, mavuto adayamba kumapeto kwa tchuthi.

Nthawi inayake patsiku tinali tisanadziwe shuga. Tidafunafuna zifukwa zonse ndi chidwi chonse komanso kufunsa kwa dotolo. Zotsatira zake, poyamba adadzudzula anthu onse oyipa a Levemir.

Ku Tresib, kusinthaku kunali kokulirapo, koma vuto la kudzipatula kwa shuga m'mawa sizinatheretu.

Chifukwa chake, pakati pa mawonekedwe osinthika a nthawi yayitali kapena yolemera (Levemir ndi Tresiba), ndimasankha makina owoneka mwapadera, momwe mutha kukhazikitsa kamvekedwe kosiyanasiyana ka nthawi iliyonse, ndikusinthanso munthawi yeniyeni.

Kodi kuchita insulin nthawi yayitali ndi chiyani?

Insulin ya munthu ndi mahomoni opangidwa ndi kapamba. Zofanizira zake ndizopanga ma insulini zatsopano, zomwe zimagwiritsidwa ntchito mwachangu ku insulin. Kodi ma insulini omwe akhala akuchita kwa nthawi yayitali ndi ati? Mankhwala osakanikirana amadziwitsidwa ndi nthawi yochita mthupi, makamaka pali:

• mwachangu
• zazifupi
• zochita zapakati
• kuchitapo kanthu kwa nthawi yayitali.

Amalembedwanso ndi:

• pazabwino kwambiri
• kusamalira
• njira yolowa mthupi.

Kutenga nthawi yayitali insulin ndi mitundu yawo

Chithandizo chamtunduwu chimasiyanitsa mitundu iwiri ya insulin yomwe imatenga nthawi yayitali:

Zinthu zonsezi ndi madzi osungunuka, oyambira, zolembedwa zakumbuyo zachilengedwe. Amapangidwa pogwiritsa ntchito ukadaulo wachilengedwe, samakhala ndi zochitika zambiri motero, ndipo ngati kuli koyenera, nthawi zambiri amatha kuphatikizidwa ndi ma insulin othamanga komanso osakhalitsa.

Amachepetsa shuga m'magazi akamagwira mwachangu komanso mwachangu akasiya kugwira ntchito. Amayamba kupereka mphamvu yawo patatha maola pafupifupi 4 pambuyo pa kukhazikitsa, kufikira zofunika kwambiri m'magazi pambuyo pa maola 8 mpaka 12 ndikuwonetsa kugwira ntchito kwa maola 20-36.

Zochita zawo zikufanana ndi ntchito yachilengedwe yopangidwa ndi kapamba, yomwe imathandizira kuwongolera kuchuluka kwa glucose pakati pa chakudya. Kumasulidwa-kumasulidwa ma insulins amagwira ntchito kumbuyo.

Jakisoni wambiri wa insulin sakhala pachakudya chomwe chimapangitsa kuti mahomoni azikhala ndi magazi nthawi zonse.

Asanadye chakudya chamaguluga, wodwala matenda ashuga amafunika jakisoni wina wosakhalitsa. Insulin yotalika nthawi zambiri imaperekedwa m'mawa kuyambira maola 7 mpaka 8 komanso usiku kuyambira maola 22 mpaka 23.

Malangizo a mankhwalawa nthawi zambiri amasungidwa kwakanthawi kochepa mpaka magazi atachotsedwa.

Long insulin Glargin, mawonekedwe apamwamba

Dzina lachipatala la hormone yophatikiza ndi Glargin ndi Lantus. Mankhwala obayira jakisoni ndi mtundu wa anthropogenic wa mahomoni omwe amapangidwa m'thupi la munthu. Itha kugwiritsidwa ntchito pochiza matenda amtundu wa 2 komanso matenda amtundu wa 2, imatha kubayidwa katatu patsiku ndipo sangathe kuchepetsedwa ndi mahomoni ena kapena mankhwala omwe ali mu syringe yomweyo.

Kunja, ndi njira yopanda utoto wa mahomoni ophatikizira jakisoni. Ndi analogue yobwerezanso insulin yamunthu yokhala ndi nthawi yayitali kwa maola 24. Mankhwalawa amapezeka ndi ukadaulo wama DNA womwe umapangidwanso, komwe ma laboratori osagwiritsa ntchito mankhwala a Escherichia coli K12 amachita ngati chinthu chochokera.

Mwamwambo, mankhwala Glargin ndi osiyana ndi insulin yaumunthu, popeza imakhala ndi Insulin Glargin, itasungunuka ndi madzi osalala. Mililita iliyonse ya Lantus kapena Insulin Glargine imaphatikizapo mayunitsi 100 (3.6378 mg) yopanga Insulin Glargine yokhala ndi pH ya 4.

Kodi glulin yotalika ya insulin imagwira ntchito bwanji?

Pamene ilowa m'thupi kudzera mu minofu ya adipose ya subcutaneous adipose, imasinthika ndipo imapanga microprecipitate, kuchokera komwe Insulin Glargin imapangidwa. Izi zimakupatsani mwayi:

• sinthani mphamvu ya shuga m'magazi am'magazi,
• amalimbikitsa kukoka kwa shuga ndi ziwalo ndi zotumphukira,
• ziletsa kupanga shuga m'magazi a chiwindi,
• pondani lipolysis mu adipocytes ndi proteinolysis,
• phatikizani kaphatikizidwe kazakudya zama protein.

Mankhwala Detemir, mfundo zofunika

Mankhwala okhala ndi dzina la Detemir amatchedwa Levemir, amatchedwanso Levemir Penfill ndi Levemir FlexPen. Monga mankhwala am'mbuyomu, Detemir ndi wa ma insulin omwe amagwira ntchito kwa nthawi yayitali ndipo amatha kutchedwa kopi yakumbuyo ya mahomoni amunthu.

Pambuyo poyambitsa matenda ashuga m'thupi, mahomoni amakhudzana ndi ma membrane ena a kunja kwa cytoplasmic membrane amaselo ndikupanga insulin-receptor chinthu chomwe chimayambitsa zochitika mkati mwake, kuphatikizapo kaphatikizidwe kazinthu zambiri zama enzymes, monga hexokinase, glycogen synthetase ndi pyruvate kinase. Kuyankha kwa pharmacodynamic kwa thupi pakudziwitsa yankho la timadzi timeneti kumatengera mlingo womwe watengedwa.

Pochiritsira, Detemir ya mahomoni nthawi zambiri imayendetsedwa ndi jakisoni mu ntchafu kapena mbali yakumaso. Mankhwalawa amatha kugwiritsidwa ntchito nthawi 1-2 patsiku. Kwa odwala omwe ali ndi zaka zapamwamba komanso zam'mbuyo, odwala matenda ashuga omwe ali ndi matenda a chiwindi ndi impso, ndikofunikira kuyang'anira kuchuluka kwa shuga wamagazi ndikusintha mlingo wa mankhwalawa.

Levemir ndi wamfupi kuposa Lantus, chifukwa chake amamugwirira ntchito kawiri patsiku.

Kusamala Mukamagwiritsa Ntchito Insulin Yaitali

Musanayambe kugwiritsa ntchito mahomoni aliwonse, muyenera kudziwitsa dokotala wanu za kupezeka kwa izi kapena mankhwala ena, komanso kupereka dokotala mbiri yachipatala, makamaka ngati wodwala ali ndi matenda a impso kapena chiwindi.

Jakisoni wa insulin angayambitse hypoglycemia - shuga wotsika wamagazi, yemwe amakhala ndi chizungulire, kuzizira, kusawona bwino, kufooka, mutu, komanso kukomoka.

Zina mwazotsatira zoyipa za jakisoni ndi kupweteka, kuwonda ndi kutupa pakhungu m'thupi la mankhwala, lipodystrophy, limodzi ndi kuchuluka kwa thupi, kutupa manja ndi miyendo. Nthawi zina, mankhwalawa amatha kuyambitsa kumangidwa kwa mtima, makamaka ngati wodwala watenga thiazolidinedione.

Zoyenera kusankha - Lantus kapena Levemir?

Ndizofunikira chifukwa zimawonetsa mtundu wokhazikika pazimatata, wopanda mapichesi ndi mahipisi (dongosolo la insulin lomwe limakhalapo kwa nthawi yayitali limawoneka ngati parabola wam'kati ndipo limatsata kuyang'ana kwathanzi lathanzi lachiberekero zachilengedwe).

Lantus ndi Detemir amadziwonetsa ngati amtundu wokhazikika komanso wolosera kwambiri za mankhwalawa. Amachita chimodzimodzi mwa odwala osiyana zaka kapena amuna ndi akazi.

Tsopano, odwala matenda ashuga sayenera kusakaniza mitundu yosiyanasiyana ya mankhwala kuti apange jakisoni wa insulin yowonjezera, ngakhale kale ndi mtundu wapakatikati wa Protafan idawonedwa ngati njira yovuta komanso yopatula nthawi.

Pa bokosi la Lantus zikuwonetsedwa - mankhwalawa ayenera kugwiritsidwa ntchito pakatha milungu 4 kapena masiku 30 bokosi litatsegulidwa kapena kusweka.

Levemir, ngakhale ili ndi malo osungirako ozizira kwambiri, ikhoza kusungidwa nthawi yayitali 1.5.

Ngati wodwala amatsatira zakudya zamafuta ochepa komanso mtundu wachiwiri wa shuga, ndiye kuti angathe kumangokhala pamankhwala ochepa a insulin. Chifukwa chake, Levemir ndi yoyenera kugwiritsa ntchito.

Zowona zochokera kuchipatala zimati: Lantus imawonjezera chiopsezo cha khansa. Mwinanso chifukwa chomwe amanenera ndi chakuti Lantus ali pachibwenzi kwambiri ndi kukula kwa mahomoni a maselo a khansa.

Zambiri pokhudzidwa ndi Lantus ku khansa sizikutsimikiziridwa mwatsatanetsatane, koma kuyesa ndi ziwerengero zapeza zotsutsana.

Levemir imawononga ndalama zochepa ndipo pochita sizolakwika kuposa Detemir. Choyipa chachikulu cha Detemir ndikuti sichingasakanizidwe ndi zothetsera zilizonse, ndipo Levemir atha, ngakhale osagwirizana.

Nthawi zambiri, odwala komanso omwe amatsatira endocrinologists amakhulupirira kuti ngati mulingo wambiri wa insulin umayendetsedwa, ndiye kuti ndibwino kugwiritsa ntchito jakisoni imodzi ya Lantus. Levemir pankhaniyi azigwiritsidwa ntchito kawiri patsiku, chifukwa chake, pakufunika kwakukulu kwa mankhwalawa, Lantus imapindulitsa kwambiri.

Kugwiritsa ntchito mankhwala a insulin operekedwa ndi amayi apakati

Njira ndi kutha kwa kutenga pakati pa kugwiritsa ntchito ma insulin kwa nthawi yayitali sikusiyana ndi pakati mwa amayi omwe amapatsidwa mitundu ina ya mankhwalawa.

Komabe, ziyenera kukumbukiridwa kuti kufunikira kwa mahomoni mu trimester yoyamba (m'miyezi itatu yoyambirira ya kubereka) kumatha kuchepa pang'ono, ndipo mu 2nd ndi 3 trimesters - kuchuluka.

Pambuyo pobadwa kwa mwana, kufunikira kwa insulin yokhala ndi nthawi yayitali, monga mankhwala enanso ofanana, kumatsika kwambiri, komwe kumakhala ndi chiopsezo chotenga hypoglycemia. Izi ndizofunikira kukumbukira pakusintha kwa insulin yayitali, makamaka kwa odwala omwe amalephera impso, matenda ashuga, nephropathy, komanso hepatic pathologies.

Wochedwa insulin

Cholinga cha insulin yochita ntchito yayitali ndicho kukhala woyambira kapena insulansi yoyambirira, imayendetsedwa kamodzi kapena kawiri pa tsiku. Kukhazikika kwa zochita zawo kumachitika pambuyo pa maola atatu mpaka anayi, kusintha kwakukulu kumadziwika pambuyo pa maola 810.

Kuwonetsedwa kumatenga maola 14-16 pamtengo wotsika (mayunitsi 8-10), ndi mlingo waukulu (20 magawo kapena kupitilira) maola 24.

Ngati ma insulin omwe amagwira ntchito kwa nthawi yayitali amalembedwa muyezo wopitilira 0.6 ma kilogalamu imodzi ya kulemera kwa thupi tsiku lililonse, amagawidwa majekiti 2 3, omwe amaperekedwa m'malo osiyanasiyana a thupi.

Zida zomwe zimagwiritsidwa ntchito nthawi yayitali anthu atakhala ndi insulin: Ultlente, Ultratard FM, Humulin U, Insumanbazal GT.

Posachedwa, kufananizira kwa mankhwala omwe akhala akuchita kwa nthawi yayitali Detemir ndi Glargine amayamba kuzolowera. Poyerekeza ndi ma insulin omwe amakhala osagwira ntchito kwa nthawi yayitali, mankhwalawa amadziwika ndi zochita za pakhungu zomwe zimakhala kwa maola 24 ndipo sizikhala ndi zotsatira zapamwamba (zapamwamba).

Amachepetsa kwambiri glucose ndipo samayambitsa hypoglycemia yausiku. Kutalika kwakukulu kwa ntchito ya glargine ndi chinyengo chifukwa cha kuchepa kwapadera pamalo a jekeseni wawo wofikirira kumtunda, phewa, kapena m'mimba. Malo a insulin amayenera kusinthidwa ndi jakisoni aliyense.

Mankhwalawa, omwe amaperekedwa kamodzi patsiku, monga glargine, kapena mpaka kawiri patsiku, monga detemir, amatha kwambiri kuthandizira insulin.

Tsopano glargine yatchuka kale, yopangidwa pansi pa dzina lamalonda Lantus (magawo zana a insulin glargine). Lantus amapangidwa mu mbale 10 ml, syringe pens ndi 3 ml cartridgeges.

Zotsatira za mankhwalawa zimayamba ola limodzi pambuyo pa kutha kwa kayendedwe ka subcutaneous, nthawi yayitali pafupifupi maola 24, maola 29.

Kutentha kwa zotsatira za insulin iyi pa glycemia panthawi yonse yochita zinthu kumatha kusiyanasiyana, onse odwala ndi munthu m'modzi.

Odwala omwe ali ndi matenda a shuga 1 amadziwika kuti Lantus ndiye insulin yayikulu. Odwala omwe ali ndi matenda a shuga a mtundu wachiwiri amatha kupereka mankhwalawa monga njira yokhayo yothandizira, komanso kuphatikiza ndi mankhwala ena omwe amapangitsa kuti shuga azikhala wamphamvu.

Mukamasintha kwa insulin yayitali kapena yapakatikati kupita ku Lantus, nthawi zambiri, ndikofunikira kusintha Mlingo wa tsiku ndi tsiku wa insulin yayikulu kapena kusintha njira yothandizira antidiabetic ya mulingo komanso kuchuluka kwa mapiritsi a insulin kapena kuchuluka kwa mapiritsi ochepetsa shuga.

Kusunthira jekeseni imodzi ya Lantus yatsiku ndi jekeseni awiri a Isofan insulin amafunikira kuchepetsedwa kwa mlingo wa basal insulin m'milungu yoyamba yamankhwala kuti achepetse vuto la nocturnal hypoglycemia. Nthawi yonseyi, kuti muchepetse mulingo wa Lantus, kulipira kuchuluka kwa milingo yaying'ono ya insulin.

Insulin yayitali panthawi yoyembekezera

Njira ya kubereka komanso yobereka pakugwiritsidwa ntchito ndi Lantus ilibe kusiyana kulikonse kwa odwala pakati omwe ali ndi matenda ashuga, omwe amalandiranso kukonzekera kwina kwa insulin.

Inde, ziyenera kukumbukiridwa kuti zofunikira za insulin panthawi yayitali kwambiri (miyezi itatu yoyambirira) zimatha kuchepa kwambiri, kenako zimachulukana pang'onopang'ono. Mwana akangobadwa, kufunika kwa Lantus kumacheperachepera, monga momwe zimakhalira ndi ma insulin ena, limodzi ndi izi, chiopsezo cha hypoglycemia chikuwonjezeka.

Kufunika kwa insulin, kuphatikiza Lantus, kuwonjezera, kumatha kuchepa kwa odwala omwe ali ndi matenda ashuga nephropathy, aimpso komanso kulephera kwambiri kwa chiwindi.

Mankhwala olimbikitsidwa

Kunenepa - Kupanga modabwitsa kwa antioxidant komwe kumapereka moyo watsopano mu metabolic syndrome komanso matenda ashuga. Kuchita bwino ndi chitetezo cha mankhwalawa zimatsimikiziridwa. Mankhwala akulimbikitsidwa kuti agwiritsidwe ntchito ndi Russian Diabetes Association. Tanthauzirani zina

Bongo

Pakadali pano, mlingo wa insulini sunadziwike, womwe ungayambitse mankhwala osokoneza bongo ambiri. Komabe, hypoglycemia imatha kukula pang'onopang'ono. Izi zimachitika ngati ndalama zambiri zakwaniritsidwa.

Kuti achire mu mtundu wina wa hypoglycemia, wodwalayo ayenera kumwa shuga, shuga kapena chakudya chamagulu mkati.