Diabeteson mv 30 mg: mtengo ndi malangizo a odwala matenda ashuga

Chimodzi mwazinthu zofunikira kwambiri kuti zithetsere matenda a shuga ndikukhazikika kwamisempha ya shuga. Chifukwa chake, pogula othandizira a hypoglycemic Diabeteson MV 30 mg, malangizo ogwiritsira ntchito ayenera kuphunziridwa mosamala kuti athane ndi matendawa.

Kukhala m'gulu lachigawo lachiwiri la sulfonylurea, mankhwalawa amachepetsa shuga wamagazi ndikuchotsa zisonyezo za matenda osokoneza bongo omwe amadalira insulin.

Ziwerengero zokhumudwitsa zikuwonetsa kuti kuchuluka kwa matendawa kukukulira chaka chilichonse. Pali zinthu zambiri zomwe zimapangitsa izi, koma pakati pawo, majini komanso moyo wongokhala ndiyofunika kuusamalira.

Mankhwala a Diabeteson MV 30 mg samangokulitsa kuchuluka kwa glycemia, komanso amalepheretsa kukula kwamavuto ambiri a shuga, mwachitsanzo, retinopathy, nephropathy, neuropathy ndi ena. Chachikulu ndikudziwa momwe mungamwe mankhwalawo molondola, zomwe tikambirana m'nkhaniyi.

Zambiri zamankhwala

Diabeteson MV 30 ndi mankhwala otsogola otchuka padziko lonse lapansi. Amapangidwa ndi kampani ya ku France yafakitale ya Les Laboratoires Serviceier Іndustrie.

Wothandizidwa ndi hypoglycemic amagwiritsidwa ntchito pazomwe sizidalira insulin, pomwe masewera olimbitsa thupi ndi kudya moyenera sizingathandize kuchepetsa magazi. Kuphatikiza apo, chimodzi mwazomwe zikuwonetsa kugwiritsa ntchito mankhwalawa ndikupewa zovuta monga microvascular (retinopathy ndi / kapena nephropathy) ndi matenda a macrovascular (stroke kapena myocardial infarction).

Chofunikira chachikulu cha mankhwalawa ndi gliclazide - zotumphukira za sulfonylurea. Pambuyo pakukonzekera pakamwa, gawo ili limalowa kwathunthu m'matumbo. Zolemba zake zimawonjezeka pang'onopang'ono, ndipo mulingo wambiri umafika mkati mwa maola 6-12. Ndikofunika kudziwa kuti kudya sikukugwira mankhwalawa.

Mphamvu ya gliclazide imalimbikitsidwa kuti ikulimbikitse kupanga kwa insulin ndi maselo a beta a kapamba. Kuphatikiza apo, thunthu limakhala ndi hemovascular effect, ndiye kuti, limachepetsa mwayi wa thrombosis m'matumba ang'onoang'ono. Gliclazide pafupifupi imapukusidwa kwathunthu m'chiwindi.

Kuchotsa chinthu kumachitika mothandizidwa ndi impso.

Malangizo ogwiritsira ntchito mankhwalawa

Wopangayo amatulutsa mankhwalawo ngati mapiritsi a mitundu yosiyanasiyana (30 ndi 60 mg), kuwonjezera apo, ndi odwala akuluakulu okha omwe amatha kumwa.

Diabeteson MV 30 mg ingagulidwe pa pharmacy kokha ndi mankhwala a dokotala. Chifukwa chake, adotolo amawona kuthekera kwa kugwiritsa ntchito mapiritsi awa, malinga ndi kuchuluka kwa glycemia komanso mkhalidwe wabwinobwino wodwala.

Ndikulimbikitsidwa kumwa mankhwalawa kamodzi patsiku chakudya cham'mawa. Kuti muchite izi, piritsi liyenera kumeza ndi kutsukidwa ndi madzi osafuna kutafuna. Ngati wodwalayo adayiwala kumwa mapiritsi panthawi, kuletsa kuchuluka kwa mankhwalawo kumaletsedwa.

Mlingo woyambirira wa hypoglycemic ndi 30 mg patsiku (piritsi limodzi). Mwanjira yosaiwalika ya shuga, njirayi imatha kupereka chiwongolero chokwanira cha shuga. Kupanda kutero, dokotala amawonjezera kuchuluka kwa mankhwalawa kwa wodwala, koma osapitirira masiku 30 mutamwa koyamba. Wachikulire amaloledwa kudya monga momwe angathere patsiku la Diabeteson MV 30 mpaka 120 mg.

Pali machenjezo ena okhudza kugwiritsa ntchito mankhwalawa kwa anthu opitilira zaka 60, komanso odwala omwe ali ndi vuto la uchidakwa, matenda a impso kapena chiwindi, kuperewera kwa glucose-6-phosphate dehydrogenase, kuchepa kwa pituitary kapena adrenal, mtima pathologies ndi hypothyroidism. Zikatero, katswiri amasankha mosamala mlingo wa mankhwalawo.

Malangizo omwe aphatikizidwa akuti mankhwalawa amayenera kusungidwa pa 30 ° C kuchokera pomwe ana ang'ono. Moyo wa alumali uyenera kuwonetsedwa phukusi.

Pambuyo pa nthawi imeneyi, mankhwala amaletsedwa.

Contraindication ndi zomwe zingavulaze

Diabeteson MV 30 mg ndi wopanga odwala osakwana zaka 18. Kuchepetsa izi kumachitika chifukwa cha kusowa kwa chidziwitso pa chitetezo cha ndalama kwa ana ndi achinyamata.

Palibenso chochitika chogwiritsa ntchito hypoglycemic wothandizila panthawi yoyembekezera komanso mkaka wa m'mawere. Munthawi ya bere, njira yoyenera kwambiri yolamulira glycemia ndi insulin. Pankhani yakonzekera kubereka, muyenera kusiya kugwiritsa ntchito mankhwala ochepetsa shuga ndikusintha jakisoni wa mahomoni.

Kuphatikiza pa zotsutsana pamwambapa, kabuku kamalangizo kokhala ndi mndandanda wa matenda ndi mikhalidwe momwe Diabeteson MV 30 amaletsedwa kugwiritsa ntchito. Izi zikuphatikiza:

shuga wodalira insulin
kugwiritsa ntchito miconazole,
matenda ashuga ketoacidosis,
Hypersensitivity ku zigawo zikuluzikulu kapena zothandiza,
matenda a shuga
hepatic ndi / kapena kulephera kwa aimpso (mu mawonekedwe owopsa).

Chifukwa chogwiritsa ntchito molakwika kapena mankhwala osokoneza bongo, zimachitika zosafunika. Zikachitika, muyenera kusiya kumwa mankhwalawo ndikupempha thandizo kwa dokotala. Mungafunike kusiya kumugwiritsa ntchito ngati madandaulo a wodwalayo akukhudzana ndi:

Ndi kutsika msanga kwamisempha.
Ndi malingaliro osatha aanjala ndikuwonjezera kutopa.
Ndi chisokonezo komanso kukomoka.
Ndi kudzimbidwa, mseru komanso kusanza.
Ndikupweteka mutu komanso chizungulire.
Ndi kufooketsa chidwi cha chidwi.
Ndimapuma mosapumira.
Ndi masomphenya olankhula ndi vuto.
Ndi kukwiya, kusakwiya komanso kukhumudwa.
Ndi ozungulira minofu contraction.
Ndi kuthamanga kwa magazi.
Ndi bradycardia, tachycardia, angina pectoris.
Ndi khungu zimachitika (kuyabwa, zidzolo, erythema, urticaria, Quincke edema).
Ndi zochita zamwano.
Ndikululuka thukuta.

Chizindikiro chachikulu cha mankhwala osokoneza bongo ndi hypoglycemia, yomwe imatha kutha ndi chakudya chokhala ndi zophatikizika mosavuta m'mimba (shuga, chokoleti, zipatso zotsekemera). Wodwala kwambiri, wodwalayo akayamba kugona kapena kugontha, ayenera kuchipatala. Njira imodzi yosinthira shuga m'magazi ndi kugwiritsa ntchito shuga. Ngati ndi kotheka, mankhwala othandizira amachitidwa.

Kuphatikiza ndi njira zina

Pamaso pa matenda ophatikizana, ndikofunikira kuti wodwalayo afotokozere amene amuthandiza. Kusasunga chidziwitso chofunikira ngati ichi kungakhudze mavuto a mankhwala a diabeteson MV 30 pawokha.

Monga mukudziwa, pali mitundu ingapo ya mankhwala omwe amatha kupititsa patsogolo,, kapena, kufooketsa mphamvu ya wothandizira wa hypoglycemic. Zina mwa izo zimatha kubweretsanso mavuto ena.

Mankhwala ndi magawo omwe amawonjezera mwayi wa hypoglycemia:

Miconazole
Phenylbutazone.
Ethanoli
Sulfonamides.
Pizz.
Acarbose.
Ultrashort insulin.
Mankhwala osokoneza bongo oletsa kuponderezana.
Clarithromycin
Metformin.
GPP-1 agonists.
Mao zoletsa.
Dipeptidyl peptidase-4 zoletsa.
Beta blockers.
ACE zoletsa.
Fluconazole
H2-histamine receptor blockers.

Mankhwala ndi zinthu zomwe zimathandizira mwayi wa hyperglycemia:

Danazole
Chlorpromazine
Glucocorticosteroids,
Tetracosactide,
Salbutamol,
Ritodrin
Terbutaline.

Tiyenera kudziwa kuti munthawi yomweyo makonzedwe a sulfonylurea ofanana ndi anticoagulants angalimbikitse zotsatira zam'mbuyo. Chifukwa chake, nthawi zina, ndikofunikira kusintha Mlingo wawo.

Pofuna kupewa zovuta zilizonse, wodwalayo ayenera kupita kwa katswiri yemwe amatha kuyesa momwe mankhwala amagwiritsidwira ntchito.

Zinthu zomwe zimakhudza mphamvu ya mankhwalawa

Osangokhala mankhwala kapena mankhwala osokoneza bongo omwe angakhudze mphamvu ya hypoglycemic wothandizira Diabeteson MV 30. Pali zinthu zina zingapo zomwe zimakhudza thanzi la munthu wodwala matenda ashuga.

Chifukwa choyamba komanso chodziwika bwino chothandizira odwala mosavomerezeka ndi kukana kapena kulephera kwa odwala (makamaka okalamba) kuwongolera thanzi lawo ndikutsatira malingaliro onse a dokotala.

Chachiwiri, chofunikanso kwambiri ndi kudya kosasamala kapena zakudya zopanda zakudya. Komanso, phindu la mankhwalawa limakhudzidwa ndi njala, kusatha kwa kuvomereza komanso kusintha kwa zakudya zomwe zimachitika.

Kuphatikiza apo, pofuna chithandizo chokwanira, wodwalayo ayenera kuwongolera kuchuluka kwa chakudya chamafuta ndi zochita zolimbitsa thupi. Kupatuka kulikonse kumawononga shuga ndi magazi.

Zachidziwikire, matenda opatsirana amakhala ndi gawo lofunikira. Choyamba, awa ndi ma endocrine pathologies omwe amaphatikizidwa ndi chithokomiro cha chithokomiro komanso gustini, komanso kupweteka kwambiri kwa impso ndi hepatic.

Chifukwa chake, pofuna kukwaniritsa kukhazikika kwa glucose ndikuchotsa chizindikiro cha matenda ashuga, wodwalayo ndi katswiri wake wowachiritsira amafunika kuthana kapena kuchepetsa mphamvu ya zinthu zomwe zili pamwambapa.

Mtengo, ndemanga ndi fanizo

Mankhwala a Diabeteson MV 30 mg atha kugulidwa ku pharmacy iliyonse kapena kuyitanidwa pa intaneti pa tsamba lovomerezeka la wogulitsa. Mtengo wa mankhwalawa umatengera kuchuluka kwa mapiritsi omwe ali phukusi. Chifukwa chake, mtengo wa phukusi wokhala ndi mapiritsi 30 a 30 mg aliyense umachokera ku 255 mpaka 288 rubles, ndipo mtengo wa phukusi wokhala ndi mapiritsi 60 a 30 mg aliyense umachokera ku 300 mpaka 340 rubles.

Monga mukuwonera, mankhwalawa amapezeka kwa wodwala aliyense amene ali ndi ndalama, zomwe, ndizowonjezera zazikulu. Pambuyo popenda ndemanga zabwino za odwala matenda ashuga, titha kuzindikira zina za mankhwalawa:

Kugwiritsa ntchito bwino limodzi ndi jakisoni wa insulin.
Chiwopsezo chochepa cha zotsatira zoyipa.
Kukhazikika kwa glycemia.

Komabe, nthawi zina, panali kuchepa kwamphamvu kwa shuga, komwe kunathetsedwa chifukwa chomwa chakudya. Mwambiri, malingaliro a madotolo ndi odwala okhudzana ndi mankhwalawa ndi abwino. Pogwiritsa ntchito mapiritsi moyenera ndikutsatira malingaliro onse omwe dokotala angakupatseni, mutha kukwaniritsa kuchuluka kwa shuga ndikupewa zoyipa. Tiyenera kukumbukira kuti okhawo odwala omwe:

kutsatira zakudya zabwino,
kusewera masewera
samalani pakati pa kupuma ndi ntchito,
lawani shuga
yesetsani kupewa kukhumudwa komanso kukhumudwa.

Ena amagwiritsa ntchito mankhwalawa pomanga thupi kuti achulukitse minofu. Komabe, madokotala amachenjeza kugwiritsa ntchito mankhwalawa pazifukwa zina.

Ndi kukula kwa zovuta kapena chifukwa chakuwonekera, dokotala ali ndi vuto pakusankhidwa kwa mankhwala ena omwe angakhale ndi vuto ngati lomweli. Diabeteson MV ili ndi mitundu yambiri. Mwachitsanzo, pakati pa mankhwala omwe ali ndi gliclazide yogwira, zotchuka kwambiri ndi:

Glidiab MV (ma ruble 140),
Glyclazide MV (ma ruble 130),
Diabetalong (ma ruble 105),
Diabefarm MV (ma ruble 125).

Mwa zokonzekera zomwe zimakhala ndi zinthu zina, koma kukhala ndi zotsatira zofanana za hypoglycemic, munthu amatha kusiyanitsa Glemaz, Amaril, Gliclada, Glimepirid, Glyurenorm, Diamerid ndi ena.

Ndizofunikira kudziwa kuti posankha mankhwala, wodwalayo samangoganizira momwe amagwirira ntchito, komanso mtengo wake. Chiwerengero chachikulu cha analogu chimapangitsa kusankha njira yoyenera kwambiri poyerekeza mtengo ndi mtundu.

Diabeteson MV 30 mg - chida chothandiza pa matenda a matenda a shuga a 2. Mukagwiritsidwa ntchito moyenera, mankhwalawa amathandizira kuchepetsa shuga ndikuyiwala za zizindikiro za "matenda okoma" kwa nthawi yayitali. Chachikulu ndichakuti musaiwale zomwe dokotala akuwongolera ndikukhala ndi moyo wathanzi.

Katswiri kuchokera pa kanema munkhaniyi azikamba za mankhwala a Diabeteson.

Fomu ya Mlingo:

Zopangidwa:
Piritsi limodzi lili:
Chithandizo: gliclazide - 30.0 mg.
Othandizira: calcium hydrogen phosphate dihydrate 83.64 mg, hypromellose 100 cP 18.0 mg, hypromellose 4000 cP 16.0 mg, magnesium stearate 0,8 mg, maltodextrin 11.24 mg, anhydrous colloidal silicon dioxide 0,32 mg.

Kufotokozera
Mapiritsi oyera, a biconvex oval omwe adalemba ndi "DIA 30" mbali imodzi ndi logo ya kampani inayo.

Gulu la Pharmacotherapeutic:

ZOCHULUKA ZA PHARMACOLOGICAL
Mankhwala
Glyclazide ndi sulfonylurea yotumphukira, mankhwala a hypoglycemic pamlomo, omwe amasiyana ndi mankhwala omwewo mwa kukhalapo kwa mphete ya N - yokhala ndi heterocyclic yokhala ndi mgwirizano wa endocyclic.
Glyclazide amachepetsa kuchuluka kwa shuga m'magazi, zomwe zimapangitsa kuti insulin ikhale ndi mas cell a Langerhans. Kuwonjezeka kwa ndende ya postprandial insulin ndi C-peptide kumapitirira pambuyo pa zaka 2 za mankhwala.
Kuphatikiza pa momwe zimapangidwira kagayidwe kazakudya, gliclazide imakhala ndi mphamvu ya m'mitsempha.
Zokhudza insulin katulutsidwe
Mtundu wachiwiri wa matenda a shuga, mankhwalawa amabwezeretsa chiyambi champhamvu cha insulin chifukwa cha kuchuluka kwa glucose ndikuwonjezera gawo lachiwiri la insulin secretion. Kuwonjezeka kwakukulu kwa insulin katulutsidwe kumawonedwa poyankha kukondoweza chifukwa cha kudya kapena kutsika kwa shuga.
Kukhudzika kwa mtima
Glyclazide amachepetsa chiopsezo cha mtsempha wamagazi wama mtsempha, komwe kumayambitsa masheya omwe angayambitse kukula kwa zovuta za matenda osokoneza bongo: kuletsa kwapang'onopang'ono kwa kuphatikiza kwa mapulateni ndi kutsekeka komanso kuchepa kwa kuchuluka kwa mapulogalamu am'magazi (beta-thromboglobulin, thromboxane B2), komanso kubwezeretsa minofu ya fibrinolytic. kuchuluka kwa minofu plasminogen activator.
Kuwongolera kwambiri kwa glycemic kutengera kugwiritsa ntchito Diabeteson® MV (HbA1c Njira yakuyendetsa glycemic kwambiri ikuphatikiza kupezeka kwa mankhwala a Diabeteson ® MV ndikuwonjezera mlingo wake motsutsana ndi maziko a (kapena m'malo mwake) mankhwalawa olimbitsa thupi asanawonjezerenso mankhwala ena a hypoglycemic (mwachitsanzo, metformin, alpha-glucosidase inhibitor , zotumphukira za thiazolidinedione kapena insulin. Pakatikati tsiku lililonse, mankhwalawa a diabeteson® MV odwala omwe ali ndi gulu lowongolera anali 103 mg, okwanira tsiku lililonse mlingo anali 120 mg.
Poyerekeza ndi kagwiritsidwe ntchito ka mankhwala a Diabeteson ® MV pagulu lowongolera glycemic (gulu lotsatiridwa nthawi 4.8 zaka, HbA1c level 6.5%) poyerekeza ndi gulu lolamulira wamba (kuchuluka kwa HbA1c level 7.3%), kutsika kwakukulu kwa 10% kukuwonetsedwa chiopsezo cha kuphatikiza pafupipafupi kwa macro- ndi microvascular zovuta
Ubwino unakwaniritsidwa pakuchepetsa kwambiri chiopsezo chaching'ono: zovuta zazikulu za microvascular ndi 14%, kuyambika ndi kupitilira kwa nephropathy ndi 21%, kupezeka kwa microalbuminuria ndi 9%, macroalbuminuria ndi 30% komanso kukula kwa aimpso ndi 11%.
Ubwino wowongolera glycemic kwambiri mukamamwa Diabeton® MV sizinadalire phindu lomwe mumapeza ndi antihypertensive therapy.

Pharmacokinetics
Pambuyo pakukonzekera pakamwa, gliclazide imangodzaza. Kuchulukana kwa gliclazide mu madzi a m'magazi kumawonjezeka pang'onopang'ono, mpaka kukafika kumapiri pambuyo pa maola 6 mpaka 12. Kusintha kwamunthu aliyense ndi kotsika.
Kudya sizikhudzana ndi kuchuluka kwa mankhwalawa. Ubale pakati pa kumwa womwe watengedwa (mpaka 120 mg) ndi dera lomwe lili pansi pa pharmacokinetic pamapindikira Pafupifupi 95% ya mankhwalawa amamangiriza mapuloteni a plasma. Glyclazide imapukusidwa makamaka m'chiwindi ndipo imakhudzidwa makamaka ndi impso: chimbudzi chimachitika mu mawonekedwe a metabolites, osakwana 1% omwe amatsitsidwa ndi impso osasinthika. Palibe metabolites yogwira mu plasma.
Hafu ya moyo wa gliclazide ndi pafupifupi maola 12 mpaka 20. Kuchuluka kwa magawo ndi pafupifupi malita 30.
Okalamba, palibe kusintha kwakukulu pama paracminetic paraceter.
Kumwa mankhwala a diabeteson ® MV muyezo wa 30 mg kamodzi patsiku kumathandizira kuti azisungika gliclazide yogwira plasma kwa maola opitilira 24.

MALO OGWIRITSITSA NTCHITO Ntchito
Type 2 shuga mellitus osakwanira mutha kudya mankhwala, zolimbitsa thupi ndi kuchepa thupi.
Kupewa mavuto obwera chifukwa cha matenda a shuga: kuchepetsa chiopsezo cha maselo am'mimba (nephropathy, retinopathy) ndi zovuta zina (myocardial infarction, stroke) mwa odwala omwe ali ndi matenda a shuga a 2 mellitus kwambiri.

Hypersensitivity to gliclazide, zotumphukira zina za sulfonylurea, sulfonamides kapena zotulutsa zomwe ndi mbali ya mankhwala,
mtundu 1 shuga
matenda ashuga ketoacidosis, matenda a shuga, matenda ashuga,
kwambiri aimpso kapena chiwindi kulephera (mu izi, tikulimbikitsidwa kugwiritsa ntchito insulin)
chithandizo chogwirizana ndi miconazole (onani gawo "Kuyanjana ndi mankhwala ena"),
mimba ndi mkaka wa m`mawere (onani gawo "Nthawi ya pakati ndi nthawi ya mkaka wa m'mawere"),
wazaka 18.

Simalimbikitsidwa kugwiritsidwa ntchito limodzi ndi phenylbutazone ndi danazole (onani gawo "Kuyanjana ndi mankhwala ena").
Ndi chisamaliro:
Okalamba, osakhazikika komanso / kapena osagwiritsa ntchito zakudya, kuchepa kwa glucose-6-phosphate dehydrogenase, matenda owopsa a mtima dongosolo, hypothyroidism, adrenal kapena pituitary insufficiency, aimpso ndi / kapena kulephera kwa chiwindi, chithandizo chotalikilapo ndi glucocorticosteroids (GCS), uchidakwa.

KULAMBIRA KOPANDA CHINENERO
Mimba
Palibe zinachitikira ndi gliclazide pa nthawi yapakati. Zomwe zimagwiritsidwa ntchito pazinthu zina za sulfonylurea panthawi yapakati ndizochepa.
Mu maphunziro a nyama yothandizira, teratogenic zotsatira za gliclazide sizinadziwikebe.
Kuchepetsa chiopsezo cha kubadwa mwatsopano, kuwongolera koyenera (chithandizo choyenera) cha matenda osokoneza bongo ndikofunikira.
Mankhwala a Oral hypoglycemic pa nthawi yoyembekezera sagwiritsidwa ntchito.
Insulin ndi mankhwala osankhidwa ochizira matenda a shuga mwa amayi apakati.
Ndikulimbikitsidwa kuti m'malo mankhwalawa pakhale kumwa kwa mankhwala a hypoglycemic omwe ali ndi vuto la insulin pokhapokha ngati muli ndi pakati, komanso ngati kutenga pakati kumachitika pakumwa mankhwalawo.
Kuyamwitsa
Poganizira kusowa kwa chidziwitso cha kudya kwa gliclazide mkaka wa m'mawere ndi chiopsezo chokhala ndi hypoglycemia mwa mwana woyamwa, kuyamwitsa kumayesedwa panthawi ya mankhwala.

ULEMEKEZO NDI KULAMULIRA
DZIKO LAPANSI NDI GALITSE MOPANDA KUKULA KWA ATSOGOLO.
Mlingo wovomerezeka wa mankhwalawa (mapiritsi a 1-4, 30-120 mg) ayenera kumwedwa pakamwa, 1 nthawi patsiku, makamaka pakudya kwam'mawa.
Ndikulimbikitsidwa kuti piritsi limezedwe lonse popanda kutafuna kapena kuphwanya.
Ngati mwaphonya mtundu umodzi kapena zingapo za mankhwalawo, simungathe kutenga mlingo wambiri muyezo lotsatira, mlingo womwe mwasowa uyenera kumwa tsiku lotsatira.
Monga mankhwala ena onse a hypoglycemic, mlingo wa mankhwalawa uliwonse umayenera kusankhidwa payekha, kutengera kuchuluka kwa shuga ndi glycosylated hemoglobin (HbA1c).
Mlingo woyambira
Mlingo woyambitsidwa woyamba (kuphatikizapo odwala okalamba, ≥ zaka 65) ndi 30 mg patsiku.
Pofuna kuwongolera mokwanira, mankhwalawa amatha kugwiritsidwa ntchito pokonzanso mankhwala. Ndi osakwanira glycemic control, tsiku ndi tsiku mlingo wa mankhwalawa ukhoza kuchuluka mpaka 60, 90 kapena 120 mg.
Kukula kwa mankhwalawa ndikotheka osati kale kuposa mwezi umodzi wotsatira wa mankhwala osokoneza bongo omwe adalandira kale. Chosiyana ndi odwala omwe magazi a glucose awo sanachepe pambuyo pa milungu iwiri. Zikatero, mlingo utha kuwonjezeka patatha masabata awiri chiyambireni kukhazikitsa.
Pazipita tsiku lililonse la mankhwalawa ndi 120 mg.

Kutembenuka kuchokera ku Diabeteson ® 80 mg mapiritsi a odwala a shuga ® 30 mg mapiritsi osinthika
Piritsi limodzi la mankhwala a Diabeteson ® 80 mg lingasinthidwe ndi piritsi 1 ndikumasulidwa Diabeteson ® MV 30 mg. Mukasamutsa odwala kuchokera ku Diabeteson ® 80 mg kupita ku Diabeteson ® MV, kuyang'anira mosamala glycemic ndikulimbikitsidwa.
Kusintha kuchokera ku mankhwala ena a hypoglycemic kupita ku Diabeteson ® 30 mg mapiritsi osinthika
Mankhwala a Diabeteson ® MV mapiritsi okhala ndi mtundu wosinthika wa 30 mg angagwiritsidwe ntchito m'malo mwa mankhwala ena a hypoglycemic pakumwa pakamwa. Mukasamutsa odwala omwe amalandila mankhwala ena a hypoglycemic pakumwa kwa pakamwa kwa Diabeteson ® MV, mlingo wawo ndi theka la moyo uyenera kukumbukiridwa. Monga lamulo, nthawi yosintha siyofunikira.
Mlingo woyambirira uyenera kukhala 30 mg ndipo kenaka umatenthedwa malinga ndi kuchuluka kwa shuga m'magazi.
Diabeteson ® MV ikadzalowedwa ndi zotumphukira za sulfonylurea ndi moyo wautali wa moyo kupewa hypoglycemia yoyambitsidwa ndi kuwonjezereka kwa othandizira awiri a hypoglycemic, mutha kusiya kuwatenga kwa masiku angapo. Mlingo woyambirira wa mankhwalawa Diabeteson ® MV nthawi yomweyo ulinso 30 mg ndipo, ngati pakufunika, utha kuwonjezereka mtsogolo, monga tafotokozera pamwambapa.
Kuphatikizika kwa ntchito ndi mankhwala ena a hypoglycemic
Diabeteson ® MB ikhoza kugwiritsidwa ntchito limodzi ndi Biguanides, alpha-glucosidase inhibitors kapena insulin.
Ndi osakwanira pakuwongolera glycemic, mankhwala owonjezera a insulin ayenera kuyikidwa ndi kuyang'aniridwa mosamala kuchipatala.

Odwala okalamba
Kusintha kwa Mlingo kwa odwala okulirapo zaka 65 sikofunikira.

Odwala omwe ali ndi vuto la impso Zotsatira za kafukufuku wazachipatala zawonetsa kuti kusintha kwa mlingo kwa odwala omwe ali ndi kufatsa pang'ono komanso aimpso sikufunika. Pafupifupi kuyang'anira kuchipatala ndikulimbikitsidwa.
Odwala omwe Ali pachiwopsezo cha Hypoglycemia
Odwala omwe ali pachiwopsezo cha kukhala ndi hypoglycemia (chakudya chokwanira kapena chosakwanira, zovuta za endocrine zowonongeka - kuchepa kwa thupi ndi vuto la adrenal, hypothyroidism, kuthetsedwa kwa glucocorticosteroids (GCS) atagwiritsidwa ntchito kwa nthawi yayitali komanso / kapena makonzedwe akulu. mtima dongosolo - kwambiri mtima matenda, carotid arteriosulinosis, wamba atherosulinosis, tikulimbikitsidwa kugwiritsa ntchito osachepera 30 mg wa prep Ata Diabeton ® MV.

Kupewa matenda ashuga
Kuti mukwaniritse kuyang'anira kwambiri glycemic, mutha kuwonjezera pang'onopang'ono mlingo wa mankhwalawa Diabeteson ® MV mpaka 120 mg / tsiku kuwonjezera pa zakudya ndi masewera olimbitsa thupi kuti mukwaniritse chandamale cha HbA1c. Kumbukirani kuopsa kokhala ndi hypoglycemia. Kuphatikiza apo, mankhwala ena a hypoglycemic, mwachitsanzo, metformin, alpha glucosidase nigibitor, thiazolidinedione derivative kapena insulin, amatha kuwonjezeredwa ku mankhwala.

Ana ndi achinyamata ochepera zaka 18.
Zambiri pakugwiritsa ntchito mankhwalawa kwa ana ndi achinyamata osakwana zaka 18 sizipezeka.

ZOTHANDIZA ZONSE
Poganizira momwe zinachitikira ndi gliclazide ndi zina zochokera ku sulfonylurea, zotsatirazi zoyipa ziyenera kulingaliridwa.
Hypoglycemia
Monga mankhwala ena a gulu la sulfonylurea, Diabeteson ® MV imatha kuyambitsa hypoglycemia chifukwa cha zakudya zosafunikira makamaka makamaka ngati zakudya zikusowa. Zizindikiro zotheka za hypoglycemia: kupweteka mutu, kugona kwambiri, nseru, kusanza, kuchuluka kwa kutopa, kusokonezeka, kugona, kuchepa chidwi, kufulumira, kugwiritsidwa ntchito, kukhumudwa, kusawona bwino komanso kulankhula, kuphwanya, kugwedezeka, kuzindikira. , chizungulire, kufooka, kupsinjika, bradycardia, delirium, kulephera kupuma, kugona, kusowa chikumbumtima ndi chitukuko cha chikomokere, mpaka kumwalira.
Kuchitikanso kwa Andrenergic kungatchulidwenso: thukuta lochulukirapo, khungu “lokaka”, nkhawa, tachycardia, kuthamanga kwa magazi, palpitations, arrhythmia, ndi angina pectoris.
Monga lamulo, Zizindikiro za hypoglycemia zimayimitsidwa pomwa chakudya (shuga).
Kutenga zotsekemera sikugwira ntchito. Poyerekeza ndi zam'mbuyo za zinthu zina zochokera ku sulfonylurea, zotulukanso za hypoglycemia zidadziwika pambuyo pakupuma bwino.
Mu hypoglycemia yayitali kapena yayitali, chithandizo chamankhwala mwadzidzidzi chafotokozedwa, mwina ndi kuchipatala, ngakhale zitakhala kuti pali zotsatira za kumwa chakudya.

Zotsatira zina zoyipa

Kuchokera m'mimba thirakiti: kupweteka kwam'mimba, nseru, kusanza, kutsegula m'mimba, kudzimbidwa. Kumwa mankhwalawa mukamadya kadzutsa kumapewa Zizindikiro kapena kuwachepetsa.

Zotsatira zotsatirazi ndizochepa:

Pa khungu ndi subcutaneous minofu: zotupa, kuyabwa, urticaria, erythema, maculopapullous zidzolo, zidzolo.
Kuchokera kuzinthu zamagazi ndi zam'mimba: zovuta za hematological (anemia, leukopenia, thrombocytopenia, granulocytopenia) ndizosowa. Monga lamulo, zochitika izi zimatha kusintha ngati chithandizo chitha.
Kumbali ya chiwindi ndi ma biliary thirakiti: ntchito yowonjezera ya "chiwindi" michere (aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase), hepatitis (magawo ena akutali). Ngati cholestatic jaundice ichitika, mankhwalawa ayenera kusiyidwa.

Zotsatira zotsatirazi nthawi zambiri zimatha kusintha ngati chithandizo chitha.

Kuchokera kumbali ya gawo la masomphenyawo: kusokonezeka kowoneka kwakanthawi kumatha kuchitika chifukwa cha kusintha kwa kuchuluka kwa shuga m'magazi, makamaka kumayambiriro kwa chithandizo.
Zotsatira zoyipa zomwe zimachokera ku sulfonylurea zotumphukira: mukamamwa mankhwala ena a sulfonylurea, zotsatirazi zoyipa zimadziwika: erythrocytopenia, agranulocytosis, hemolytic anemia, pancytopenia, alculgic vasculitis ndi hyponatremia. Panali kuwonjezeka kwa ntchito ya "chiwindi" michere, chiwindi ntchito (mwachitsanzo, ndikupanga cholestasis ndi jaundice) ndi chiwindi, mawonetseredwe amachepetsa patapita nthawi atasiya kukonzekera kwa sulfonylurea, koma nthawi zina zimapangitsa kuti chiwindi chisawonongeke.

Zotsatira zoyipa zomwe zimadziwika mu mayesero azachipatala
Mu kafukufuku wa ADVANCE, panali kusiyana pang'ono kawirikawiri pazovuta zazikulu zingapo pakati pamagulu awiriwa. Palibe zatsopano zachitetezo zomwe zalandilidwa. Odwala ochepa anali ndi hypoglycemia yayikulu, koma kuchuluka kwa hypoglycemia kunali kotsika. Zotsatira za hypoglycemia pagulu lolamulira la glycemic zinali zochuluka kuposa zomwe zinali pagulu lolamulira. Magawo ambiri a hypoglycemia omwe ali pagulu lolamulira glycemic amawonetsedwa motsutsana ndi maziko a insulin yothandizira.

CHONCHO
Ngati bongo wa sulfonylurea zotumphukira, hypoglycemia angayambe.
Ngati mukumva zizindikiro za hypoglycemia popanda kudziwa kukhudzika kapena mawonekedwe amitsempha, muyenera kuwonjezera kudya zamankhwala ambiri ndi chakudya, muchepetse mlingo wa mankhwalawo komanso / kapena musinthe kadyedwe. Kuyan'ana zamankhwala kwa wodwalayo kuyenera kupitiliza mpaka pakukhulupirira kuti palibe chomwe chingawononge thanzi lake.
Mwina chitukuko cha matenda oopsa a hypoglycemic, limodzi ndi chikomokere, kukomoka kapena matenda ena amanjenje. Ngati zizindikiro zotere zikuwoneka, chithandizo chamankhwala chodzidzimutsa ndi kuchipatala mwachangu ndikofunikira.
Pankhani ya chikumbumtima cha hypoglycemic kapena ngati akukayikira, wodwala amapaka jekeseni wamadzi 50 ml yankho la 20-30% dextrose (glucose). Kenako, 10% dextrose solution imayendetsedwa moyenera kuti ikhalebe magazi osakanikirana pamwamba pa 1 g / L. Kuyang'anira bwino shuga ndikutsata wodwalayo kuyenera kuchitidwa kwa maola osachepera 48.
Pambuyo pa nthawi yino, kutengera mtundu wa wodwalayo, adokotala amafunikira pakuwunika ntchito zina. Kutsegula m'mimba sikugwira ntchito chifukwa cha kutchulidwa kwa gliclazide kwa mapuloteni a plasma.

KUGWIRITSANA NDIPONSO ZITSANZO ZINA
1) Mankhwala osokoneza bongo omwe amachulukitsa chiopsezo cha hypoglycemia:
(kukulitsa mphamvu ya gliclazide)
Kuphatikiza kophatikizidwa
- Miconazole (ndi makonzedwe oyenera komanso mukamagwiritsa ntchito gel osakaniza pakamwa): imakweza mphamvu ya hypoglycemic ya gliclazide (hypoglycemia ikhoza kukhala mpaka kukomoka).
Osavomerezeka kuphatikiza
- Phenylbutazone (kachitidwe ka makonzedwe): kumawonjezera mphamvu ya hypoglycemic ya zotumphukira za sulfonylurea (zimawachotsa kuti asalumikizane ndi mapuloteni a plasma ndipo / kapena kuchedwetsa kutulutsa kwawo mthupi).
Ndikofunika kugwiritsa ntchito mankhwala ena odana ndi kutupa. Ngati phenylbutazone ndiyofunikira, wodwalayo ayenera kuchenjezedwa za kufunika koyang'anira glycemic. Ngati ndi kotheka, mlingo wa mankhwalawa Diabeteson ® MV uyenera kusinthidwa pamene mukumwa phenylbutazone ndi pambuyo pake.
- Ethanol: kumawonjezera hypoglycemia, kuletsa zovuta zochita, kungathandizire kukulitsa kukomoka kwa hypoglycemic. Ndikofunikira kukana kumwa mankhwala, monga ethanol ndi mowa.
Njira zopewera
Gliclazide kuphatikiza ndi mankhwala ena (mwachitsanzo, othandizira ena a hypoglycemic - insulin, alpha glucosidase inhibitor, biguanides, beta-blockers, fluconazole, angiotensin-converting enzyme inhibitors - Captopril, enalapril, H2S-histamine inhibitors, non-histamine inhibitors anti-kutupa mankhwala limodzi ndi kuwonjezeka kwa hypoglycemic zotsatira ndi chiopsezo cha hypoglycemia.
2) Mankhwala omwe amachulukitsa shuga m'magazi:
(kufooketsa mphamvu ya gliclazide)
Osavomerezeka kuphatikiza
- Danazole: ali ndi matenda ashuga. Ngati kugwiritsidwa ntchito kwa mankhwalawa kuli kofunikira, wodwalayo akulimbikitsidwa kuyang'anira glycemic mosamala. Ngati ndi kotheka, molumikizana mankhwala, tikulimbikitsidwa kuti mlingo wa hypoglycemic wothandizila kusankhidwa onse munthawi ya danazol atachoka.
Njira zopewera
- Chlorpromazine (antipsychotic): muyezo waukulu (oposa 100 mg pa tsiku) kumawonjezera kuchuluka kwa shuga m'magazi, kuchepetsa kubisirana kwa insulin.
Kuwongolera mosamala glycemic ndikulimbikitsidwa. Ngati ndi kotheka kumwa mankhwala pamodzi, ndikulimbikitsidwa kuti pakhale mlingo wa antiogychotic wothandizila pambuyo pakuchoka kwa antipsychotic.
- GKS (mwatsatanetsatane komanso kwina ntchito: intraarticular, khungu, rectal management): kuwonjezera kuchuluka kwa shuga wamagazi ndi chitukuko cha ketoacidosis (kuchepa kwa kulekerera kwa chakudya chambiri). Kuwongolera mosamala glycemic ndikulimbikitsidwa, makamaka kumayambiriro kwa chithandizo. Ngati kuli kofunikira kutenga mankhwala limodzi, kusintha kwa mlingo wa hypoglycemic wothandizila kungafunike panthawi yonse yoyang'anira GCS komanso atachokapo.
- Ritodrin, salbutamol, terbutaline (mtsempha wama mtsempha): beta-2 adrenergic agonists amalimbikitsa kuchuluka kwa shuga ndende.
Iyenera kuwunika makamaka pakufunika kodziletsa. Ngati ndi kotheka, tikulimbikitsidwa kusamutsa wodwala kupita ku insulin.
3) Kuphatikiza kuyenera kukumbukiridwa
- Anticoagulants (mwachitsanzo warfarin)
Zomwe zimachokera ku sulfonylureas zimatha kupititsa patsogolo zotsatira za ma anticoagulants pamene atengedwa limodzi. Kusintha kwa mankhwalawa kwa anticoagulant kungafunike.

MALANGIZO OTHANDIZA
Hypoglycemia
Mukamamwa mankhwala a sulfonylurea, kuphatikiza gliclazide, hypoglycemia imayamba, nthawi zina imakhala yovuta kwambiri komanso imatenga nthawi yayitali, imafuna kuchipatala komanso kuyamwa kwa njira ya dextrose masiku angapo (onani gawo "Zotsatira zoyipa").
Mankhwalawa amatha kuperekedwa kwa odwala omwe kudya kwawo nthawi zonse ndikuphatikiza chakudya cham'mawa. Ndikofunika kwambiri kukhala ndi chakudya chokwanira chamagulu ochulukirapo a chakudya ndi chakudya, chifukwa chiopsezo chokhala ndi vuto la hypoglycemia chimakulirakudya chochepa kapena choperewera, komanso chakudya choperewera m'makina.
Hypoglycemia nthawi zambiri imayamba kukhala ndi zakudya zochepa zopatsa mphamvu, pambuyo pochita masewera olimbitsa thupi kwa nthawi yayitali kapena mwamphamvu, kapena mutamwa mankhwalawa angapo nthawi imodzi.
Nthawi zambiri, zizindikiro za hypoglycemia zimatha pambuyo podya chakudya chopatsa thanzi (monga shuga). Tiyenera kukumbukira kuti kutenga zotsekemera sikumathandiza kuthetsa zizindikiro za hypoglycemic. Kugwiritsa ntchito njira zina zochokera mu sulfonylurea kumapereka lingaliro lakuti hypoglycemia imatha kubwereranso ngakhale mutapumula koyenera. Ngati zizindikiro za hypoglycemic zimatchulidwa kapena ndizokhalitsa, ngakhale pakhale kusintha kwakanthawi mutatha kudya chakudya chamafuta ambiri, chithandizo chamankhwala chodzidzimu ndikofunikira, mpaka kuchipatala.
Kuti mupewe kukula kwa hypoglycemia, kusankha mosamala mankhwala ndi mankhwala ena, ndikofunikira kupatsa wodwalayo chidziwitso chonse chamankhwala.
Chiwopsezo chowonjezeka cha hypoglycemia chitha kupezeka pazotsatirazi:

kukana kapena kulephera kwa wodwala (makamaka okalamba) kutsatira zomwe dokotalayo wapereka ndikuwunika momwe alili,
Zakudya zosakwanira komanso zosagwirizana, kulumpha zakudya, kusala komanso kusintha zakudya,
kusagwirizana pakati pa zolimbitsa thupi ndi kuchuluka kwa chakudya chotengedwa,
kulephera kwa aimpso
kulephera kwambiri kwa chiwindi
mankhwala osokoneza bongo a Diabeteson ® MV,
zovuta zina za endocrine: matenda a chithokomiro, kuchepa kwa pituitary ndi adrenal,
kugwiritsa ntchito munthawi yomweyo mankhwala ena (onani gawo "Kuyanjana ndi mankhwala ena"). Mawonetseredwe azachipatala a hypoglycemia amatha kutsekedwa mukatenga beta-blockers, clonidine, reserpine, guanethidine.

Kulephera kwamkati ndi chiwindi
Odwala omwe ali ndi hepatic komanso / kapena aimpso kulephera, pharmacokinetic ndi / kapena pharmacodynamic katundu wa gliclazide angasinthe.
Mkhalidwe wa hypoglycemia womwe umayamba mwa odwala amatha nthawi yayitali, m'malo oterowo, chithandizo chamankhwala chofunikira ndikofunikira.

Zidziwitso Zodwala
Ndikofunikira kudziwitsa wodwalayo, komanso anthu am'banja lake, za chiopsezo chotenga hypoglycemia, zizindikiro zake komanso zikhalidwe zomwe zimapangitsa kuti akule. Wodwala ayenera kudziwitsidwa za zoopsa zomwe zingachitike ndi chithandizo cha chithandizo chomwe akufuna.
Wodwala amafunika kufotokoza bwino kufunika kwa kudya, kufunika kochita masewera olimbitsa thupi nthawi zonse ndikuwunika kuchuluka kwa shuga m'magazi.
Mafuta osakwanira a shuga
Kuwongolera kwa glycemic mwa odwala omwe amalandira chithandizo cha hypoglycemic kungafooketse pazotsatirazi: chithandizo chachikulu cha opaleshoni ndikuvulala, kuwotcha kwakukulu, matenda opatsirana omwe ali ndi febrile syndrome. Ndi mikhalidwe imeneyi, zingakhale zofunikira kusiya mankhwala ndi mankhwala a shuga a Diabeteson ® MV ndikupereka mankhwala a insulin.
Mwa odwala ena, mphamvu ya othandizira pakamwa hypoglycemic, kuphatikizapo gliclazide, amayamba kuchepa pambuyo pakupita nthawi yayitali. Izi zimatha kukhala chifukwa cha kupitilira kwa matendawa komanso kuchepa kwa yankho la mankhwalawa. Izi zimadziwika kuti yachiwiri ya kukana mankhwala, yomwe iyenera kusiyanitsidwa ndi yoyamba, pomwe mankhwalawa samapereka zomwe akuyembekezeredwa kachipatala atangoyamba kumene. Musanazindikire wodwala ndi kukana kwachiwiri kwa mankhwala, ndikofunikira kuyesa kuchuluka kwa kusankha kwa mankhwalawa ndikutsatira wodwala malinga ndi zakudya zomwe wapatsidwa.

Mayeso a labu
Kuti mupeze kuwongolera kwa glycemic, kutsimikiza mtima kosalekeza m'magazi a glucose komanso glycated hemoglobin HbA1c akulimbikitsidwa. Kuphatikiza apo, ndikofunikira kuti nthawi zonse azichita kudziwunika kwa shuga wamagazi.
Zotumphukira za Sulfonylurea zimatha kupangitsa hemolytic kuchepa magazi kwa odwala omwe ali ndi shuga-6-phosphate dehydrogenase. Popeza gliclazide imachokera ku sulfonylurea, chisamaliro chiyenera kuthandizidwa pakaperekedwa kwa odwala omwe ali ndi vuto la shuga-6-phosphate dehydrogenase.
Kuthekera kopereka mankhwala a hypoglycemic a gulu lina kuyenera kuwunikiridwa.

KUPEMBEDZA KWA KUGWIRA NTCHITO YAKUKHALA NDI MOYO NDI KUGWIRITSA NTCHITO KUTI MUKUFUNA KUKHALA NDI MTIMA WOPANDA MALO OGULITSIRA MIYALA NDI ZIWANDA
Odwala ayenera kudziwa zizindikiro za hypoglycemia ndipo ayenera kusamala mukamayendetsa kapena kugwira ntchito yofunika kuthana ndi ziwopsezo zambiri ndimaganizo, makamaka kumayambiriro kwa zamankhwala.

MALO A ISSUE
30 mg mapiritsi otulutsidwa
30 mapiritsi pachimake (PVC / Al), matuza 1 kapena 2 omwe ali ndi malangizo ogwiritsira ntchito kuchipatala pabokosi la makatoni.
Mukamayala (ma CD) ku Russia kampani LLC Serdix: Mapiritsi 30 pachimake (PVC / Al), matuza awiri okhala ndi malangizo ogwiritsira ntchito pabokosi lamatoni.

CHITSANZO CHOKHA
Zosungira zapadera sizofunikira.
Pewani kufikira ana.
Mndandanda B.

MOYO WABWINO
Zaka zitatu Osagwiritsa ntchito tsiku lotha ntchito likusonyezedwa pa phukusi.

VACATION TERMS
Ndi mankhwala.

Satifiketi Yalembetsa yomwe idaperekedwa ndi a Server Laboratories, France

Yopangidwa ndi Serighere Lab Lab, France
"Makampani Othandizira Ntchito":
905, msewu waukulu wa Saran, 45520 Gidey, France
905, njira kuchokera ku Saran, 45520 Gidy, France

Mwa mafunso onse, funsani ofesi ya Representative of JSC "Servicework Laborator".

Zoyimira JSC "Laborator Labour":
115054, Moscow, Paveletskaya pl. d.2, p. 3

Serdix LLC:
142150, Russia, Moscow Region,
Chigawo cha Podolsky, mudzi wa Sof'ino, tsamba 1/1

Satifiketi Yalembetsa yomwe idaperekedwa ndi a Server Laboratories, France
Yopangidwa ndi: Serdix LLC, Russia
Serdix LLC:
142150, Russia, Moscow Region,
Chigawo cha Podolsky, mudzi wa Sof'ino, tsamba 1/1
Mwa mafunso onse, funsani ofesi ya Representative of JSC "Servicework Laborator".

Zoyimira JSC "Laborator Labour":
115054, Moscow, Paveletskaya pl. d.2, p. 3