Humalog - malangizo ogwiritsira ntchito, ma analogi, ndemanga ndi kumasula (syringe cholembera waPPPP yothetsera kapena kuyimitsidwa kwa Mix 25 ndi 50 insulin) ya mankhwala ochizira matenda amtundu wa 1 ndi mtundu wa matenda ashuga achikulire, ana komanso nthawi yapakati

Munkhaniyi, mutha kuwerengera malangizo ogwiritsira ntchito mankhwalawa Chichewa. Amapereka ndemanga kuchokera kwa alendo omwe amabwera patsamba lino - ogula mankhwalawa, komanso malingaliro a akatswiri azachipatala pakugwiritsa ntchito Humalog machitidwe awo. Chopempha chachikulu ndikuti muwonjezere ndemanga zanu za mankhwalawa: mankhwalawo adathandizira kapena sanathandizire kuchotsa matendawa, ndizovuta ziti zomwe zimawoneka ndi zotsatirapo zake, mwina sizinalengezedwe ndi wopanga. Ma Analogs a Humalog pamakhala ma analogues omwe amapezeka. Gwiritsani ntchito pochiza matenda amiseche 1 amtundu wa shuga (wodalira insulin komanso osadalira insulin) mwa akulu, ana, komanso panthawi yoyembekezera komanso mkaka wa m'mawere. The zikuchokera mankhwala.

Chichewa - analogue ya insulin yaumunthu, imasiyana ndi kusintha kwatsatanetsatane wa proline ndi lysine amino acid zotsalira pamalo 28 ndi 29 a insulin B. Poyerekeza ndikukonzekera kwanthaŵi yayitali insulin, lyspro insulin imadziwika ndi kuyambika mwachangu komanso kutha kwake, komwe kumachitika chifukwa chakuchotsa kwina kuchokera kumalo osasunthika chifukwa cha kusungidwa kwa mawonekedwe a monomeric a lyspro insulin mamolekyulu mu yankho. Kukhazikika kwa mphindi 15 pambuyo pa kayendetsedwe ka subcutaneous, mphamvu yayikulu imakhala pakati pa maola 0.5 ndi maola 2,5, kutalika kwa nthawi ndi maola 3-4.

Humalog Mix ndi DNA - maumboni odziwika a insulin yaumunthu ndipo ndi chosakanikirana chopangidwa chopangidwa ndi lyspro insulin solution (analog yothamanga ya insulin yaumunthu) ndi kuyimitsidwa kwa lyspro protamine insulin (anthawi yapakati ya insulin analogue).

Chochita chachikulu cha insulin lyspro ndi malamulo a kagayidwe ka glucose. Kuphatikiza apo, imakhala ndi anabolic komanso anti-catabolic zotsatira zosiyanasiyana zamthupi. Mu minofu ya minofu, pali kuchuluka kwa glycogen, mafuta acid, glycerol, kuchuluka kwa mapuloteni komanso kuwonjezereka kwa kumwa ma amino acid, koma nthawi yomweyo kumachepa mu glycogenolysis, gluconeogeneis, ketogeneis, lipolysis, proteinabolism ndi kutulutsidwa kwa ma amino acid.

Kupanga

Lyspro insulin + akubwera.

Pharmacokinetics

Kukwanira kwathunthu ndi kuyambika kwa mphamvu ya insulin kumadalira malo a jakisoni (m'mimba, ntchafu, matako), mlingo (kuchuluka kwa insulin), komanso kuchuluka kwa insulin pokonzekera. Imagawidwa mosiyanasiyana mu minofu. Simadutsana chotchinga ndi mkaka wa m'mawere. Amawonongedwa ndi insulinase makamaka m'chiwindi ndi impso. Amachotseredwa ndi impso - 30-80%.

Zizindikiro

lembani matenda a shuga 1 mellitus (wodalira insulin), kuphatikiza ndi tsankho kukonzekera kwina kwa insulin, ndi postprandial hyperglycemia yomwe singathe kukonza ma insulin, kukonzekera kwachulukidwe kakang'ono ka insulini (kuthamanga kwa kuchepa kwa insulin),
lembani matenda a shuga 2 oletsa kutsatsa

Kutulutsa Mafomu

Njira yothetsera kulowetsedwa kwamkati mwa 100 IU mu katoni kathengo ka 3 ml wophatikizidwa ndi cholembera cha QuickPen kapena cholembera.

Kuyimitsidwa kwa subcutaneous makonzedwe a 100 IU mu katoni 3 ml wophatikizidwa ndi cholembera cha QuickPen kapena cholembera (Humalog Remix 25 ndi 50).

Mitundu ina ya kumwa, ngati mapiritsi kapena mapiritsi, kulibe.

Malangizo ogwiritsira ntchito ndi njira yogwiritsira ntchito

Mlingo umayikidwa payekha. Lyspro insulin imayang'aniridwa subcutaneous, mu mnofu kapena kudzera m'mitsempha 5-15 asanadye. Mlingo umodzi ndi 40 magawo, owonjezera amangololedwa pokha pokha. Ndi monotherapy, Lyspro insulin imayang'aniridwa katatu pa tsiku, pamodzi ndi kukonzekera kwa insulin yayitali - katatu patsiku.

Mankhwalawa amayenera kuperekedwa mosavuta.

Intravenous makonzedwe a mankhwala Humalog Remix ali contraindicated.

Kutentha kwa mankhwala omwe amaperekedwa kuyenera kukhala kutentha kwambiri.

Subcutaneally ayenera jekeseni phewa, ntchafu, matako kapena m'mimba. Masamba a jakisoni ayenera kusinthidwa kuti malo omwewo asagwiritsidwerenso nthawi 1 pamwezi. Mukamayambitsa mankhwalawa Humalog, chisamaliro chiyenera kutengedwa kuti mupewe magazi. Pambuyo pa jakisoni, tsamba la jakisidwe siliyenera kutenthedwa.

Poika makatoni mu chipangizo cha jakisoni wa insulin ndikulowa ndi singano musanayendetsedwe ka insulin, malangizo a wopanga chipangizo cha insulin amayenera kuwonetsetsa.

Malangizo akukhazikitsa mankhwala Humalog Remix

Kukonzekera mawu oyamba

Musanagwiritse ntchito, cartridge yosakanikirana ya Humalog Mix iyenera kukukhidwira pakati pama manja khumi ndikugwedezeka, kutembenuka ndi 180 ° komanso maulendo khumi kuti ipatsenso insulin mpaka iwoneke ngati madzi osalala kapena mkaka. Gwedezani mwamphamvu, monga izi zimatha kuyambitsa foam, zomwe zingasokoneze mlingo woyenera. Kupangitsa kusakanikirana, katiriji kamakhala ndi mkanda wawung'ono wagalasi. Mankhwala sayenera kugwiritsidwa ntchito ngati ali ndi ziphuphu mutatha kusakaniza.

Momwe mungapangire mankhwalawa

Sambani manja.
Sankhani malo pobayira.
Chitani khungu ndi antiseptic pamalo omwe jakisoni (ndi kudzivulaza, mogwirizana ndi malingaliro a dokotala).
Chotsani kapu yakunja yoteteza ku singano.
Sinthani khungu ndikakukoka kapena kusunga khola lalikulu.
Ikani singano pang'onopang'ono ndikuchita jakisoni mogwirizana ndi malangizo ogwiritsa ntchito cholembera.
Chotsani singano ndikufinya pang'onopang'ono malo a jakisoni kwa masekondi angapo. Osatupa malo a jakisoni.
Pogwiritsa ntchito chopukutira chakunja cha singano, dulani singano ndikuwononga.
Ikani chipewa pa cholembera.

Zotsatira zoyipa

hypoglycemia (hypoglycemia yayikulu imatha kutha kwa chikumbumtima ndipo, mwapadera, mpaka kufa),
redness, kutupa, kapena kuyabwa pamalowo jakisoni (nthawi zambiri zimatha patadutsa masiku angapo kapena masabata, nthawi zina izi zimachitika chifukwa cha zifukwa zosagwirizana ndi insulin, mwachitsanzo, kupweteka pakhungu ndi jakisoni woletsa kapena jekeseni wosayenera),
kuyamwa kofananira
kuvutika kupuma
kupuma movutikira
kutsika kwa magazi,
tachycardia
kutuluka thukuta kwambiri
chitukuko cha lipodystrophy pamalo jakisoni.

Contraindication

achina,
Hypersensitivity pamagawo a mankhwala.

Mimba komanso kuyamwa

Mpaka pano, palibe zotsatira zosasangalatsa za Lyspro insulin pa mimba kapena mkhalidwe wa mwana wosabadwa ndi wakhanda zadziwika.

Cholinga cha mankhwala a insulin panthawi yapakati ndikukhazikika pakukhazikika kwa shuga. Kufunika kwa insulin nthawi zambiri kumachepera mu trimester yoyamba ndikuwonjezeka muyezo wachiwiri ndi wachitatu wama trimesters apakati. Nthawi yobadwa pambuyo pokhapokha ndipo mwayamba kubadwa, zofunika za insulin zimatha kugwa kwambiri.

Amayi amisinkhu yokhala ndi matenda ashuga ayenera kudziwitsa adotolo za kuyambika kapena kukhala ndi pakati.

Odwala omwe ali ndi matenda a shuga mellitus nthawi yoyamwitsa, kusintha kwa insulin ndi / kapena zakudya kungafunike.

Malangizo apadera

Njira yoyendetsera njira yomwe imagwiritsidwa ntchito mulingo wa lyspro insulin uyenera kuyang'aniridwa bwino. Posamutsa odwala kuchokera ku insulin yomwe imakonzekera mwachangu kuchokera ku insulin lispro, kusintha kofunikira kungafunike. Kusamutsidwa kwa odwala omwe amalandira insulin tsiku lililonse mlingo wopitilira 100 PESCES kuchokera ku mtundu umodzi wa insulin kupita ku ina ndikulimbikitsidwa kuti upangidwe mu chipatala.

Kufunika kwa insulin kumatha kuwonjezeka panthawi yomwe matenda opatsirana, ndi nkhawa zam'maganizo, ndi kuchuluka kwa chakudya chamagulu mu chakudya, pazakudya zowonjezera zamankhwala omwe ali ndi vuto la hyperglycemic (mahomoni a chithokomiro, glucocorticoids, kulera kwapakamwa, thiazide diuretics).

Kufunika kwa insulin kumatha kuchepa ndi kuchepa kwaimpso komanso / kapena chiwindi, ndi kuchepa kwa kuchuluka kwa chakudya chamagulu m'zakudya, ndi kuchuluka kwa thupi, pakudya kowonjezereka kwa mankhwala omwe ali ndi hypoglycemic zochita (mao inhibitors, osasankha beta-blockers, sulfonamides).

Malangizo a hypoglycemia mu mawonekedwe owopsa amatha kuchitika ndikugwiritsa ntchito i / m ndi / kapena s / glu wa glucagon kapena iv woyendetsa shuga.

Kuyanjana kwa mankhwala osokoneza bongo

Mphamvu ya hypoglycemic ya Lyspro insulin imakonzedwa ndi Mao inhibitors, osagwiritsa ntchito beta-blockers, sulfonamides, acarbose, ethanol (mowa) ndi mankhwala okhala ndi ethanol.

Mphamvu ya hypoglycemic ya Lyspro insulin imachepetsedwa ndi glucocorticosteroids (GCS), mahomoni a chithokomiro, njira zakulera zamkati, thiazide diuretics, diazoxide, antidepressants a tricyclic.

Beta-blockers, clonidine, reserpine amatha kuphimba mawonetseredwe a zizindikiro za hypoglycemia.

Mndandanda wa mankhwala Humalog

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