Atomax (Atomax) - malangizo ogwiritsira ntchito

Mayina apadziko lonse lapansi - atomax

Kupanga ndi mawonekedwe a kumasulidwa

Mapiritsi okhala ndi mafilimu pafupifupi yoyera, yozungulira, ya biconvex, yokhala ndi notch mbali imodzi, kukwiya pang'ono kumaloledwa. Piritsi limodzi lili ndi atorvastatin (munthawi ya calcium ya calcium ya atorvastatin) 10 mg.

Othandizira: calcium carbonate - 6 mg, lactose - 52,5 mg, chimanga - 25,66 mg, croscarmellose sodium - 5.21 mg, povidone (K-30) - 3.5 mg, magnesium stearate - 2 mg, anhydrous colloidal silicon dioxide - 1.5 mg, crospovidone - 4 mg

Ma Shell: primellose 15 CPS - 2.05 mg, talc oyeretsedwa - 0,22 mg, titanium dioxide - 0,36 mg, triacetin - 0,16 mg.

Ma PC 10 - matuza (3) - mapaketi a makatoni.
Ma PC 10 - matuza (4) - mapaketi a makatoni.
Ma PC 10 - matuza (5) - mapaketi a makatoni.

Mapiritsi okhala ndi mafilimu pafupifupi yoyera, yozungulira, ya biconvex, yokhala ndi notch mbali imodzi, kukwiya pang'ono kumaloledwa. 1 piritsi ili ndi atorvastatin (munthawi ya atorvastatin calcium calcium) 20 mg.

Othandizira: calcium carbonate - 10 mg, lactose - 78.34 mg, chimanga wowuma - 40 mg, croscarmellose sodium - 10,47 mg, povidone (K-30) - 5 mg, magnesium stearate - 4 mg, anhydrous colloidal silicon dioxide - 3 mg, crospovidone - 7 mg

Ma Shell: primellose 15 CPS - 3.3 mg, talc oyeretsedwa - 0,36 mg, titanium dioxide - 0,58 mg, triacetin - 0,26 mg.

Ma PC 10 - matuza (3) - mapaketi a makatoni.
Ma PC 10 - matuza (4) - mapaketi a makatoni.
Ma PC 10 - matuza (5) - mapaketi a makatoni.

Zachipatala ndi gulu la mankhwala

Gulu la Pharmacotherapeutic

Wothandizira kutsitsa lipid ndi HMG-CoA reductase inhibitor.

Pharmacological zochita za Atomax

Hypolipidemic wothandizila kuchokera pagulu la statins. Kusankha mpikisano wosankha wa HMG-CoA reductase, enzyme yomwe imatembenuza 3-hydroxy-3-methylglutaryl coenzyme A mpaka mevalonic acid, wolamula wa sterols, kuphatikiza cholesterol. TG ndi cholesterol m'chiwindi chimaphatikizidwa mu VLDL, kulowa plasma ndipo amatengedwa kupita kuzinthu zowonjezera.

LDL imapangidwa kuchokera ku VLDL panthawi yolumikizirana ndi LDL receptors. Amachepetsa kuchuluka kwa cholesterol ndi lipoproteins mu plasma chifukwa cha kuletsa kwa HMG-CoA reductase, kapangidwe ka cholesterol m'chiwindi komanso kuchuluka kwa "chiwindi" LDL receptors pamaselo a cell, zomwe zimatsogolera pakuwonjezeka komanso kukopa kwa LDL.

Imachepetsa kupangika kwa LDL, imayambitsa kuwonjezereka komanso kulimbikira mu ntchito ya ma LDL receptors. Amachepetsa ndende ya LDL odwala omwe ali ndi homozygous Famer hypercholesterolemia, omwe nthawi zambiri samayankha pochiza ndi lipid-kuchepetsa mankhwala.

Amachepetsa kuchuluka kwa cholesterol yathunthu ndi 30-46%, LDL - mwa 41-61%, apolipoprotein B - ndi 34-50% ndi TG - mwa 14-33%, amachititsa kuchuluka kwa HDL cholesterol ndi apolipoprotein A. Mlingo-modalira umachepetsa kuchuluka kwa LDL mu odwala homozygous cholowa hypercholesterolemia kugonjetsedwa ndi mankhwala ena hypolipidemic mankhwala.

Momwe zimachepetsera chiopsezo chokhala ndi zovuta za ischemic (kuphatikizapo kukula kwa kufa kuchokera ku infarction ya myocardial) ndi 16%, chiwopsezo chogonekedwanso kuchipatala cha angina pectoris, chotsatira ndi zizindikiro za myocardial ischemia, ndi 26%. Zilibe zotsatira za carcinogenic ndi mutagenic. The achire zotsatira zimatheka patatha masabata awiri chiyambireni kuyambika kwa mankhwalawa, chimafika pakatha masabata 4 ndipo chimatha nthawi yonse ya chithandizo.

Pharmacokinetics

Mafuta ndi okwera. Nthawi yoti mufikire C_max - Maola 1-2, C_max The yogwira pophika magazi mu akazi ndi 20% apamwamba, AUC kutsika ndi 10%, Cmax mwa odwala chidakwa cirrhosis ndi 16 zina, AUC ndi 11 kukwera kuposa masiku. Kudya pang'ono kumachepetsa kuthamanga ndi kutalika kwa mankhwalawa (mwa 25% ndi 9%, motsatana), koma kuchepa kwa cholesterol ya LDL ndikofanana ndi kugwiritsidwa ntchito kwa atorvastatin popanda chakudya.

Kuchulukitsidwa kwa atorvastatin pamene ntchito madzulo kumatsika kuposa m'mawa (pafupifupi 30%). Ubale wapakati pakati pa kuchuluka kwa mayamwidwe ndi mlingo wa mankhwalawo unawululidwa. Bioavailability - 14%, zokhudza bioavailability wa zoletsa ntchito motsutsana HMG-CoA reductase - 30%.

Low systemic bioavailability imachitika chifukwa cha kagayidwe kachakudya ka mucous membrane wa m'mimba thirakiti (GIT) komanso munthawi ya "gawo loyambirira" kudzera m'chiwindi. Vd wamba ndi 381 L, kulumikizana ndi mapuloteni a plasma ndi oposa 98%. Amapangidwa makamaka mu chiwindi mothandizidwa ndi isoenzymes CYP3A4, CYP3A5 ndi CYP3A7 ndikupanga mankhwala opatsirana a chemacologic metabolites (ortho ndi para-hydroxylated, zinthu za beta oxidation).

In vitro, ortho- ndi para-hydroxylated metabolites imalepheretsa kusintha kwa GMK-CoA, kufananizidwa ndi atorvastatin. Mphamvu yoletsa kukonzekera kwa mankhwalawa motsutsana ndi HMG-CoA reductase pafupifupi 70% yotsimikizika ndi ntchito yozungulira metabolites ndipo imapitilira pafupifupi maola 20-30 chifukwa cha kupezeka kwawo. T_1/2 - Maola 14. Amapukusidwa ndi bile pambuyo pa hepatic ndi / kapena extrahepatic metabolism (siyikupezeka kutchulidwa kwatsopano). Osakwana 2% ya mlingo wa pakamwa amadziwika mu mkodzo.

Sichotsetsedwedwa pa hemodialysis chifukwa chomangirira mapuloteni a plasma.

Ndi kulephera kwa chiwindi kwa odwala omwe ali ndi zidakwa za cirrhosis (Child-Pyug B), Cmax ndi AUC zimachulukirachulukira (nthawi 16 ndi 11, motero).

C_max ndipo AUC ya mankhwalawa mu okalamba (azaka 65 zakubadwa) ali 40 ndi 30%, motero, apamwamba kuposa omwe ali ndi odwala achikulire a zaka zazing'ono (alibe mtengo wa chipatala). Cmax mwa akazi ndiwokwera 20%, ndipo AUC ndi yotsika 10% kuposa abambo (alibe mtengo).

Kulephera kwamkati sikukhudza plasma ndende ya mankhwalawa.

- kuphatikiza ndi zakudya zochizira odwala omwe ali ndi seramu TG yapamwamba (mtundu IV malinga ndi Fredrickson) ndi odwala dysbetalipoproteinemia (mtundu wa III malinga ndi Fredrickson), yemwe mankhwalawa samadya mokwanira.

- kuphatikiza ndi zakudya kuti muchepetse kuchuluka kwa cholesterol yokwanira, LDL-C, apolipoprotein B ndi TG ndikuwonjezera HDL-C odwala omwe ali ndi hypercholesterolemia, heterozygous achibale komanso osagwirizana ndi hyperlipidemia (mitundu IIa ndi IIb IIb ),

- Kuchepetsa milingo ya cholesterol yathunthu ndi LDL-C odwala omwe ali ndi homozygous Famer hypercholesterolemia, pamene mankhwala othandizira pakudya ndi njira zina zosagwiritsa ntchito mankhwalawa sizigwira ntchito mokwanira.

Mlingo

Atomax asanaikidwe, wodwalayo ayenera kulimbikitsa zakudya zochepetsa lipid, zomwe ayenera kupitiriza kuziona nthawi yonse ya chithandizo.

Mlingo woyambirira ndi pafupifupi 10 mg 1 nthawi / tsiku. Mlingo umasiyana 10 mpaka 80 mg 1 nthawi / tsiku. Mankhwala amatha kumwa nthawi iliyonse masana ndi chakudya kapena osasamala nthawi yakudya. Mlingo umasankhidwa poganizira magawo angapo a LDL-C, cholinga cha mankhwala ndi zotsatira zake. Kumayambiriro kwa mankhwalawa komanso / kapena pakuwonjezeka kwa mlingo wa Atomax, ndikofunikira kuyang'anira kuchuluka kwa plasma lipid masabata onse a 2-4 ndikusintha mlingo moyenerera.

At chachikulu hypercholesterolemia ndi hyperlipidemia yosakanikirana Nthawi zambiri, poika Atomax mu 10 mg 1 nthawi / tsiku ndikwanira. A achire kwambiri zimachitika pambuyo 2 milungu, monga lamulo, ndipo pazipita achire zotsatira nthawi zambiri amawona pambuyo 4 milungu. Ndi chithandizo cha nthawi yayitali, izi zimapitirira.

Kugwiritsa ntchito mankhwalawa odwala aimpso kulephera ndi matenda a impso sizikhudza kuchuluka kwa atorvastatin m'magazi am'magazi kapena kuchepa kwa zomwe LDL-C ikugwiritsidwa ntchito, chifukwa chake, kusintha kwa mlingo sikofunikira.

Mukamagwiritsa ntchito mankhwalawa odwala okalamba panalibe kusiyana pakukhwimitsa chitetezo, kuchita bwino, kapena kukwaniritsa zolinga zamankhwala ochepetsa lipid poyerekeza ndi anthu wamba.

Zotsatira zoyipa Atomax

Kuchokera pamalingaliro: amblyopia, kulira m'makutu, kuuma kwa conjunctiva, kusokonezeka kwa malo okhala, kutulutsa magazi, kusamva, kuchuluka kwa kupanikizika, parosmia, kupotoza kwa kukoma, kutayika kwa zomverera.

Kuchokera kumbali ya chapakati mantha dongosolo ndi zotumphukira mantha dongosolo: mutu, chizungulire, asthenic syndrome, kusowa tulo, kugona tulo, amnesia, paresthesias, zotumphukira zamitsempha, kutengeka mtima, kutopa, kunenepa, kupsinjika, Hypesthesia.

Kuchokera m'mimba: nseru, kutentha kwa mtima, kudzimbidwa kapena kutsegula m'mimba, kusokonezeka kwa m'mimba, kupweteka kwam'mimba, kupweteka kwa m'mimba, kudya, kukamwa, kugona, dysphagia, kusanza, stomatitis, esophagitis, glossitis, gastroenteritis, hepatitis, hepatic colic, cheilitis kapamba, cholestatic jaundice, kuchuluka kwa chiwindi michere (AST, ALT), magazi amitsempha, melena, magazi m`kamwa, tenesmus.

Kuchokera ku minculoskeletal system: nyamakazi, miyendo kukokana, bursitis, myositis, myopathy, arthralgia, myalgia, rhabdomyolysis, mgwirizano wolowa, kupweteka kumbuyo, kuwonjezeka kwa serum CPK.

Kuchokera pakapumidwe: bronchitis, rhinitis, dyspnea, mphumu, ndi mphuno.

Kuchokera kwamikodzo: matenda a urogenital, edema ya zotumphukira, dysuria (kuphatikizapo polakiuria, nocturia, kwamikodzo mosapitirira kapena kwamikodzo posungika, kukodza koyenera), nephritis, cystitis, hematuria, urolithiasis, albinuria.

Kuchokera pakubala: kutulutsa magazi mu maliseche, kutaya magazi muchiberekero, kuchepa kwa magazi, kuchepa kwa magazi, kuchepa kwa magazi, kusabala, kusokonezeka kwam'mimba, gynecomastia.

Dermatological zimachitika: alopecia, thukuta, chikanga, seborrhea, ecchymosis.

Kuchokera pamtima: kupweteka pachifuwa, palpitations, vasodilation, orthostatic hypotension, phlebitis, arrhythmia.

Kuchokera ku hemopoietic system: anemia, lymphadenopathy, thrombocytopenia.

Kuchokera kumbali ya kagayidwe: hyperglycemia, hypoglycemia, kulemera, kuchulukitsa kwa maphunziro a gout, malungo.

Zotsatira zoyipa: pruritus, zotupa pakhungu, dermatitis yolumikizana, kawirikawiri urticaria, angioedema, nkhope edema, photosensitivity, anaphylaxis, erythema multiforme exudative (kuphatikizapo Stevens-Johnson syndrome), poyizoni wa epidermal necrolysis (matenda a Lyell).

Contraindication Atomax

- zaka mpaka 18 (kuchita bwino ndi chitetezo sizinakhazikitsidwe),

- Matenda a chiwindi kapena kuwonjezeka kwa zochitika za seramu transaminases (zochulukirapo katatu poyerekeza ndi VGN) zosachokera,

- Hypersensitivity ku zigawo za mankhwala.

Ndi kusamala ogwiritsidwa ntchito pakumwa zoledzeretsa, wokhala ndi mbiri yodwala matenda a chiwindi, kusowa kwamphamvu kwa electrolyte, endocrine ndi matenda a metabolic, matenda oopsa, matenda oopsa (sepsis), khunyu yosalamulirika, opaleshoni yayikulu, kuvulala, matenda am'mitsempha.

Mimba komanso kuyamwa

Atomax imakhudzana ndi pakati komanso kuyamwa.

Sizikudziwika ngati atorvastatin amachotsedwa mkaka wa m'mawere. Popeza kuthekera kwa zovuta mu makanda, ngati kuli kotheka, kugwiritsa ntchito mankhwalawa panthawi yoyamwa kuyenera kuganizira kuthetsa kuyamwitsa.

Akazi azaka zaubala Pa mankhwala ayenera kugwiritsa ntchito njira zokwanira za kulera. Atorvastatin itha kutumizidwa kwa azimayi azaka zakubadwa pokhapokha ngati mwayi wokhala wochotsa umakhala wotsika kwambiri, ndipo wodwalayo akudziwitsidwa za chiopsezo chamankhwala omwe mwana angafunse.

Gwiritsani ntchito ntchito yolakwika ya chiwindi

Imakhudzidwa chifukwa cha matenda a chiwindi omwe amagwira kapena kuwonjezeka kwa zochitika za seramu transaminases (zochulukirapo katatu poyerekeza ndi VGN) zosachokera. Ntchito mosamala pakumwa zakumwa zoledzeretsa, zomwe zili ndi mbiri ya matenda a chiwindi.

Gwiritsani ntchito ntchito yolakwika yaimpso

Matenda a impso sasokoneza kukhudzana kwa atorvastatin mu madzi a m'magazi kapena zimapangitsa kagayidwe ka lipid. Pankhaniyi, kusintha kwa odwala omwe ali ndi vuto laimpso sikofunikira. Ngakhale maphunziro a odwala omwe ali ndi matenda a impso sanachitike, hemodialysis ndiyokayikitsa kwambiri kutulutsa chilolezo cha atorvastatin, popeza imagwirizana kwambiri ndi mapuloteni a plasma.

Kugwiritsa ntchito mankhwala kwa ana

Zovomerezeka: zaka mpaka zaka 18 (kuchita bwino ndi chitetezo sizinakhazikitsidwe).

Gwiritsani ntchito odwala okalamba

Mukamagwiritsa ntchito mankhwalawa odwala okalamba panalibe kusiyana pakukhwimitsa chitetezo, kuchita bwino, kapena kukwaniritsa zolinga zamankhwala ochepetsa lipid poyerekeza ndi anthu wamba.

Malangizo apadera olembetsa

Asanayambe mankhwala a Atomax, wodwalayo ayenera kuthandizidwa kudziwa zakudya zoyenera zomwe azitsatira panthawi yonse ya chithandizo.

Kugwiritsa ntchito ma HMG-CoA reductase inhibitors kuti muchepetse lipids zamagazi kungapangitse kusintha kwa magawo amomwe amomwe amachititsa ntchito ya chiwindi.

Kuchita kwa chiwindi kuyenera kuyang'aniridwa musanayambe chithandizo, masabata 6 ndi 12 pambuyo poyambira kukhazikitsidwa kwa Atomax komanso pambuyo poti mlingo uliwonse ukuwonjezeka, komanso, nthawi ndi nthawi, mwachitsanzo, miyezi isanu ndi umodzi iliyonse. Kuwonjezeka kwa ntchito ya hepatic michere mu seramu yamagazi imatha kuwonedwa pa mankhwala ndi Atomax. Odwala omwe akuwonjezera ntchito ya transaminase ayenera kuyang'aniridwa mpaka kuchuluka kwa ma enzyme kubwerera ku zabwinobwino. Zikachitika kuti ALT kapena AST mfundo zikuposa katatu kuchulukirapo kuposa VGN, tikulimbikitsidwa kuti muchepetse mlingo wa Atomax kapena musiyeni chithandizo.

Atomax iyenera kugwiritsidwa ntchito mosamala odwala omwe amamwa mowa kwambiri komanso / kapena ali ndi matenda a chiwindi, odwala matenda a chiwindi kapena kuwonjezereka kwa transaminase zochitika zosadziwika ndizotsutsana ndi mankhwalawa.

Chithandizo cha atorvastatin chingayambitse myopathy. Kuzindikira kwa myopathy (kupweteka kwa minofu ndi kufooka kophatikiza ndi kuwonjezeka kwa zochitika za CPK nthawi zopitilira 10 poyerekeza ndi VGN) kuyenera kukumbukiridwa mwa odwala omwe ali ndi myalgia, kufooka kwa minofu kapena kufooka komanso / kapena kuwonjezeka kwa zochitika za CPK. Odwala ayenera kuchenjezedwa kuti ayenera kudziwitsa dokotala nthawi yomweyo za kuwoneka kosapweteka kapena kufooka m'misempha, ngati atsagana ndi malaise kapena malungo. Therapy ya Atomax iyenera kusiyidwa ngati pakuwoneka kuwonjezeka kwazomwe zikuchitika mu ntchito za CPK kapena ngati pali myopathy yotsimikizika. Chiwopsezo cha myopathy pochiza mankhwalawa amakalasi ena amakalasi amodzi munthawi yomweyo kugwiritsa ntchito cyclosporine, fibrate, erythromycin, niacin kapena azole antifungal agents. Ambiri mwa mankhwalawa amalepheretsa CYP3A4 -edi-metabolism metabolism ndi / kapena kayendedwe ka mankhwala. Atorvastatin ndi biotransformed mothandizidwa ndi CYP3A4.Pofotokoza atorvastatin osakanikirana ndi ma fupa, erythromycin, immunosuppressive mankhwala, azole antifungal mankhwala kapena niacin mu hypolipidemic Mlingo, phindu lomwe likuyembekezeka komanso chiopsezo chamankhwala ziyenera kuyesedwa mosamala ndipo odwala ayenera kuwunikidwa pafupipafupi kuti adziwe kupweteka kwa minofu kapena kufooka, makamaka m'miyezi yoyambirira yamankhwala komanso nthawi kuchuluka Mlingo wa mankhwala. Muzochitika zotere, kutsimikiza kwa ntchito za KFK kungalimbikitsidwe, ngakhale kuti chiwongolero chotere sichimalepheretsa kukula kwa myopathy.

Pogwiritsa ntchito atorvastatin, komanso mankhwala ena a mkalasiyi, milandu ya rhabdomyolysis yolephera kupweteka chifukwa cha myoglobinuria imafotokozedwa. Therapy ya Atomax iyenera kusiyidwa kwakanthawi kapena kulekeka kwathunthu ngati pali zizindikiro za myopathy zotheka kapena choopsa chothandizira kukulitsa kulephera kwa impso chifukwa cha rhabdomyolysis (mwachitsanzo, matenda opweteka kwambiri, kusokonekera kwa mitsempha, opaleshoni yayikulu, kuvulala kwambiri, kupweteka kwakukulu, endocrine ndi electrolyte kusokonekera komanso kukomoka kosalamulirika).

Musanayambe mankhwala a Atomax, ndikofunikira kuyesa kuthana ndi hypercholesterolemia mwa kudya mokwanira, kuwonjezera zolimbitsa thupi, kuchepa thupi kwa odwala omwe ali ndi kunenepa kwambiri komanso kuthandizira zina.

Odwala akuyenera kuchenjezedwa kuti ayenera kupita kwa dokotala ngati vuto lopanda kufooka kapena kufooka kwa minofu kumachitika, makamaka ngati akuphatikizidwa ndi malaise kapena malungo.

Kukopa pa kuyendetsa magalimoto ndi kayendedwe kazinthu

Zotsatira zoyipa za Atomax pakutha kuyendetsa magalimoto ndi magwiridwe antchito sizinanenedwe.

Bongo

Chithandizo: palibe mankhwalawa enieni, mawonekedwe a chithandizo amachitika. Hemodialysis siyothandiza.

Kuchita ndi Mankhwala Ena

Chiwopsezo cha myopathy munthawi ya mankhwala ndi mankhwala ena a mkalasiyi chimawonjezeka ndikugwiritsa ntchito munthawi yomweyo cyclosporine, fibrate, erythromycin, antifungal othandizira okhudzana ndi azoles, ndi niacin.

Ndi kuyambitsa munthawi yomweyo kwa atorvastatin ndi kuyimitsidwa komwe kuli ndi magnesium ndi aluminium hydroxides, kuchuluka kwa atorvastatin mu plasma kunatsika pafupifupi 35%, komabe, kuchepa kwa mulingo wa LDL-C sikunasinthe.

Ndi munthawi yomweyo kugwiritsa ntchito atorvastatin sikukhudza ma pharmacokinetics a antipyrine, chifukwa chake, kuyanjana ndi mankhwala ena omwe amapangidwa ndi cytochrome isoenzymes yomwe siikuyembekezeka.

Ndi munthawi yomweyo kugwiritsa ntchito colestipol, plasma woipa wa atorvastatin utachepa pafupifupi 25%. Komabe, lipid-kutsitsa mphamvu ya kuphatikiza kwa atorvastatin ndi colestipol imaposa ya aliyense mankhwala payekhapayekha.

Mobwerezabwereza makonzedwe a digoxin ndi atorvastatin pa 10 mg, kuchuluka kwa ndende ya digoxin m'madzi a m'magazi sikunasinthe. Komabe, pamene digoxin imagwiritsidwa ntchito limodzi ndi atorvastatin pa mlingo wa 80 mg / tsiku, kuchuluka kwa digoxin kumawonjezeka pafupifupi 20%. Odwala omwe amalandira digoxin osakanikirana ndi atorvastatin amayenera kuonedwa.

Ndi munthawi yomweyo kugwiritsa ntchito atorvastatin ndi erythromycin (500 mg 4 nthawi / tsiku) kapena clarithromycin (500 mg 2 nthawi / tsiku), yomwe imalepheretsa CYP3A4, kuwonjezeka kwa plasma mozama kwa atorvastatin.

Ndi munthawi yomweyo kugwiritsa ntchito atorvastatin (10 mg 1 nthawi / tsiku) ndi azithromycin (500 mg 1 nthawi / tsiku), kuchuluka kwa atorvastatin m'madzi a m'magazi sikunasinthe.

Atorvastatin analibe gawo lalikulu pakukhudzidwa kwa terfenadine mu plasma yamagazi, yomwe imapangidwa makamaka ndi CYP3A4; motere, ndizokayikitsa kuti atorvastatin amatha kukhudza kwambiri magawo a pharmacokinetic a magawo ena a CYP3A4.

Pogwiritsa ntchito munthawi yomweyo atorvastatin komanso kulera kwapakamwa komwe kumakhala ndi norethindrone ndi ethinyl estradiol, kuwonjezeka kwakukulu mu AUC ya norethindrone ndi ethinyl estradiol kumawonedwa ndi pafupifupi 30% ndi 20%, motero. Izi zimayenera kuganiziridwa posankha njira yakulera yapakati ya mkazi yemwe amalandila atorvastatin.

Palibe kuyipa kwakanthawi kovomerezeka kwa atorvastatin ndi estrogens komwe kumawonedwa.

Mukamaphunzira kuyanjana kwa atorvastatin ndi warfarin ndi cimetidine, palibe kuyanjana kwakukulu kwachipatala komwe kunapezeka.

Ndi munthawi yomweyo kugwiritsa ntchito atorvastatin pa mlingo wa 80 mg ndi amlodipine pa 10 mg, ma pharmacokinetics a atorvastatin m'chigawo chofanana sanasinthe.

Kugwiritsa ntchito kwa atorvastatin ndi ma proteinase inhibitors odziwika ngati CYP3A4 inhibitors limodzi ndi kuwonjezeka kwa plasma mozama kwa atorvastatin.

Palibe zovuta zovuta zamatenda za atorvastatin ndi antihypertgency zomwe zikuwoneka.

Kusagwirizana kwa mankhwala sikudziwika.

Mankhwala Okhala Pamalo a Pharmacy

Mankhwala ndi mankhwala.

Migwirizano ndi magwiritsidwe akusungidwa

Mndandanda B. Mankhwalawa amayenera kusungidwa kuti asawonekere ana, m'malo owuma, amdima pamtunda wosaposa 25 ° C Moyo wa alumali ndi zaka 2.

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Zizindikiro zogwiritsidwa ntchito

Mankhwala Atomax imagwiritsidwa ntchito limodzi ndi zakudya kuti muchepetse kuchuluka kwa cholesterol yokwanira, LDL-C, apolipoprotein B ndi TG ndikuwonjezera HDL-C odwala omwe ali ndi hypercholesterolemia, heterozygous achibale komanso osagwirizana ndi hyperlipidemia (mitundu IIa ndi IIb II ,, limodzi ndi zakudya zochizira odwala omwe ali ndi misinkhu yambiri ya seramu TG (mtundu IV malinga ndi Fredrickson) ndi odwala omwe ali ndi dysbetalipoproteinemia (mtundu wa III malinga ndi Fredrickson), yemwe chithandizo cha zakudya sichimapereka chokwanira, kuchepetsa Nia okwana mafuta ndi LDL-C odwala ndi homozygous banja hypercholesterolemia, pamene zakudya mankhwala ndi zina mankhwala si pharmacological sachita ogwira.

Njira yogwiritsira ntchito

Asanaikidwe Atomax wodwalayo ayenera kuvomereza kuti azidya zakudya zochepetsa lipid, zomwe ayenera kupitiriza kuzitsatira panthawi yonse ya chithandizo.
Mlingo woyambirira ndi pafupifupi 10 mg 1 nthawi / tsiku. Mlingo umasiyana 10 mpaka 80 mg 1 nthawi / tsiku. Mankhwala amatha kumwa nthawi iliyonse masana ndi chakudya kapena osasamala nthawi yakudya. Mlingo umasankhidwa poganizira magawo angapo a LDL-C, cholinga cha mankhwala ndi zotsatira zake. Kumayambiriro kwa mankhwalawa komanso / kapena pakuwonjezeka kwa mlingo wa Atomax, ndikofunikira kuyang'anira kuchuluka kwa plasma lipid masabata onse a 2-4 ndikusintha mlingo moyenerera.
Mu chachikulu hypercholesterolemia ndi hyperlipidemia wosakanikirana, nthawi zambiri, kuikidwa kwa Atomax mu 10 mg 1 nthawi / tsiku ndikokwanira. A achire kwambiri zimachitika pambuyo 2 milungu, monga lamulo, ndipo pazipita achire zotsatira nthawi zambiri amawona pambuyo 4 milungu. Ndi chithandizo cha nthawi yayitali, izi zimapitirira.
Kugwiritsa ntchito kwa odwala omwe ali ndi vuto la impso ndi matenda a impso sikukhudza kuchuluka kwa atorvastatin m'magazi am'magazi kapena kuchepa kwa zomwe zili mu LDL-C pakugwiritsa ntchito, chifukwa chake, kusintha kwa mankhwalawa sikofunikira.
Mukamagwiritsa ntchito mankhwalawa odwala okalamba, panalibe kusiyana pakukhwimitsa chitetezo, kugwira ntchito kapena kukwaniritsa zolinga za lipid-kuchepetsa mankhwala poyerekeza ndi anthu ambiri.

Momwe mungatenge Atomax ndi cholesterol?

Mankhwalawa ali ngati mapiritsi. Mmbali zawo ndizowoneka bwino, pamwamba pake kali. Kumbali imodzi pali ngozi. Ali ndi chipolopolo chosungunuka, amadziwika ndi mtundu woyera. Mapiritsiwo ali ndi matuza, omwe amasindikizidwa mu bokosi lamkati lamkati.

chogwira ntchito (chigawo chachikulu), chomwe ndi atorvastatin,
wowuma chimanga
calcium carbonate
lactose
povidone
sodium croscarmellose,
silicon
anhydrous colloidal dioxide,
crospovidone.

Kodi chigamba cha mapiritsi chimapangidwa ndi chiyani? Kuchokera pa triacetin, talc yoyeretsedwa, primmeloza, titanium dioxide.

Momwe mungamwe Atomax, malangizo ogwiritsira ntchito omwe ali m'mapaketi, aliyense ayenera kudziwa. Ichi ndi mankhwala ochepetsa lipid, zomwe zimapangitsa kuti muchepetse cholesterol, yomwe imakhudza thupi la munthu. Zili m'gulu la ma statins. Komanso, mankhwalawa ndi mpikisano wosankha wa HMG-CoA reductase. Amapangidwanso kuti agwire ntchito ina: kutsitsa ma lipoproteins a plasma. Atomax imakhala ndi phindu pa otsika kachulukidwe lipoprotein padziko maselo a chiwindi.

Zotsatira zamankhwala, kuwonjezeka kodziwika kwa zochitika za LDL receptors kumawonedwa. Ndikofunikira kudziwa kuti kuchepetsedwa kwa chiwopsezo chokhala ndikuchepetsa zovuta za ischemia.

Mankhwalawa alibe mphamvu iliyonse yokhudza thupi.

Kodi kudikira zotsatira? Kuti muwone zosintha zabwino, muyenera kumwa mapiritsi osachepera milungu iwiri. Mankhwalawa ayenera kugwiritsidwa ntchito mwezi umodzi kuyambira chiyambi cha mankhwala. Maphunzirowa atatha, zotsatira zake ziziwoneka kwa nthawi yayitali.

Zizindikiro zogwiritsidwa ntchito. Atomax ndi zotchulidwa monga:

Cholesterol yayikulu.
Kuchulukitsa kwa LDL-C.
Kuwonjezeka kwa thyroglobulin ndi apolipropylene B.
Ngati mulingo wa seramu TG ukuwonjezeka.
Mu nkhani pamene dysbetalipoproteinemia amakula.

Atomax siyothandiza ngati wodwala satsata zakudya zapadera zomwe adokotala amuuzidwa. Mankhwalawa ndi othandizira ndipo amagwira ntchito molumikizana ndi zakudya zapadera.

Momwe mungatenge ndikuti Mlingo wa mankhwalawa? Asanayambe maphunziro, wodwalayo asinthane ndi zakudya zapadera za lipid. Madokotala amalimbikitsa Mlingo aliyense payekha kwa wodwala aliyense. Mankhwalawa amatha kumwa onse asanadye, pambuyo, komanso asanadye nthawi iliyonse masana. Kugwiritsa ntchito bwino kwa mankhwalawa sikuchepa.

Kodi Atomax amagwirizana bwanji ndi mankhwala ena? Zomwe mankhwalawa akagwiritsidwa ntchito limodzi ndi erythromycin kapena antifungal agents, zotsatira zoyipa za mawonekedwe a myopia zimatha kuchitika. Atomax sayenera kugwiritsidwa ntchito molumikizana ndi kuyimitsidwa komwe kumakhala ndi hydroxide mu aluminium, apo ayi, kuyika kwa atorvastatin m'magazi kumachepa komanso mphamvu yothandizira, motero.

Terfenadine angagwiritsidwe ntchito, chifukwa mankhwalawa omwe amafunsidwa masiku ano sasintha zomwe anali nazo kale. Itha kugwiritsidwa ntchito ndi estrogens - palibe choopsa chomwe chidzachitike.

Sichikutsutsana ndi Warfarin ndi Cimetidine.

Osagwiritsa ntchito ndi proteinase inhibitors, popeza kuphatikiza uku kumawonjezera kuchuluka kwa ntchito ya Atomax. Ndikofunikira kupatula zoletsa, kapena kuchepetsa mlingo. Izi zikuyenera kuchitika moyang'aniridwa ndi madokotala.

Contraindication

Contraindication kugwiritsa ntchito mankhwalawa Atomax ndi: matenda a chiwindi omwe akugwira kapena kuwonjezeka kwa zochitika za seramu transaminases (zochulukirapo katatu poyerekeza ndi VGN) zosachokera pachiwopsezo, kutenga pakati, kuyamwa, zaka zapakati pa zaka 18 (kuchita bwino ndi chitetezo sizinakhazikitsidwe), hypersensitivity ku zigawo za mankhwala.
Gwiritsani ntchito mosamala pakumwa zakumwa zoledzeretsa, zomwe zili ndi mbiri ya matenda amchiwindi, kusowa bwino kwa electrolyte, endocrine ndi matenda a metabolic, matenda oopsa, matenda oopsa a pachimake (sepsis), khunyu yosalamulirika, opaleshoni yayikulu, kuvulala, ndi matenda ammimba.

Mimba

Atomax contraindicated ntchito pa mimba ndi mkaka wa m`mawere (yoyamwitsa).
Sizikudziwika ngati atorvastatin amachotsedwa mkaka wa m'mawere. Popeza kuthekera kwa zovuta mu makanda, ngati kuli kotheka, kugwiritsa ntchito mankhwalawa panthawi yoyamwa kuyenera kuganizira kuthetsa kuyamwitsa.
Amayi a msinkhu wobereka ayenera kugwiritsa ntchito njira zokwanira zolerera panthawi ya chithandizo. Atorvastatin itha kutumizidwa kwa azimayi azaka zakubadwa pokhapokha ngati mwayi wokhala wochotsa umakhala wotsika kwambiri, ndipo wodwalayo akudziwitsidwa za chiopsezo chamankhwala omwe mwana angafunse.

Kuchita ndi mankhwala ena

Komabe, lipid-kutsitsa mphamvu ya kuphatikiza kwa atorvastatin ndi colestipol imaposa ya aliyense mankhwala payekhapayekha.
Mobwerezabwereza makonzedwe a digoxin ndi atorvastatin pa 10 mg, kuchuluka kwa ndende ya digoxin m'madzi a m'magazi sikunasinthe. Komabe, pamene digoxin imagwiritsidwa ntchito limodzi ndi atorvastatin pa mlingo wa 80 mg / tsiku, kuchuluka kwa digoxin kumawonjezeka pafupifupi 20%. Odwala omwe amalandira digoxin osakanikirana ndi atorvastatin amayenera kuonedwa.
Ndi munthawi yomweyo kugwiritsa ntchito atorvastatin ndi erythromycin (500 mg 4 nthawi / tsiku) kapena clarithromycin (500 mg 2 nthawi / tsiku), yomwe imalepheretsa CYP3A4, kuwonjezeka kwa plasma mozama kwa atorvastatin.
Ndi munthawi yomweyo kugwiritsa ntchito atorvastatin (10 mg 1 nthawi / tsiku) ndi azithromycin (500 mg 1 nthawi / tsiku), kuchuluka kwa atorvastatin m'madzi a m'magazi sikunasinthe.
Atorvastatin analibe gawo lalikulu pakukhudzidwa kwa terfenadine mu plasma yamagazi, yomwe imapangidwa makamaka ndi CYP3A4; motere, ndizokayikitsa kuti atorvastatin amatha kukhudza kwambiri magawo a pharmacokinetic a magawo ena a CYP3A4.
Pogwiritsa ntchito munthawi yomweyo atorvastatin komanso kulera kwapakamwa komwe kumakhala ndi norethindrone ndi ethinyl estradiol, kuwonjezeka kwakukulu mu AUC ya norethindrone ndi ethinyl estradiol kumawonedwa ndi pafupifupi 30% ndi 20%, motero. Izi zimayenera kuganiziridwa posankha njira yakulera yapakati ya mkazi yemwe amalandila atorvastatin.
Palibe kuyipa kwakanthawi kovomerezeka kwa atorvastatin ndi estrogens komwe kumawonedwa.
Mukamaphunzira kuyanjana kwa atorvastatin ndi warfarin ndi cimetidine, palibe kuyanjana kwakukulu kwachipatala komwe kunapezeka.
Ndi munthawi yomweyo kugwiritsa ntchito atorvastatin pa mlingo wa 80 mg ndi amlodipine pa 10 mg, ma pharmacokinetics a atorvastatin m'chigawo chofanana sanasinthe.
Kugwiritsa ntchito kwa atorvastatin ndi ma proteinase inhibitors odziwika ngati CYP3A4 inhibitors limodzi ndi kuwonjezeka kwa plasma mozama kwa atorvastatin.
Palibe zovuta zovuta zamatenda za atorvastatin ndi antihypertgency zomwe zikuwoneka.

Kutulutsa mawonekedwe ndi kapangidwe kake

Atomax ndi mankhwala omwe cholinga chake kupondereza HMG-CoA reductase, kuchititsa kuchepa kwa kapangidwe ka cholesterol m'maselo a chiwindi. Mosiyana ndi maumboni a m'badwo woyamba, Atomax ndi mankhwala opangira zinthu.

Pamsika wa pharmacological, munthu atha kupeza mankhwala opangidwa ndi kampani ya India HeteroDrags Limited ndi mbewu zapakhomo za OJSC NIZHFARM, LLC Skopinsky Pharmaceutical Plant.

Atomax imapezeka mu mawonekedwe a mapiritsi oyera omwe ozungulira mawonekedwe ake ndi mbali zotsikira. Kuchokera kumwamba amakutidwa ndi nembanemba wa filimu.Phukusi limodzi lili ndi miyala 30.

Piritsi imaphatikizapo 10 kapena 20 mg ya yogwira - atorvastatin calcium calcium.

Kuphatikiza pa gawo lalikulu, piritsi lililonse ndi chigamba chake chimakhala ndi kuchuluka kwake:

sodium croscarmellose,
oyeretsa talcum ufa
lactose mfulu
magnesium wakuba,
wowuma chimanga
calcium carbonate
povidone
silicon dioksidi madzi achilengedwe
crospovidone
triacetin

Kuphatikiza apo, kuchuluka kwa titanium dioxide kumaphatikizidwa pokonzekera.

Limagwirira zake kanthu yogwira ntchito

Monga tanenera kale, zotsatira za kuchepa kwa lipid-atoma ya Atomax zimatheka chifukwa choletsa kuchepa kwa HMG-CoA. Cholinga chachikulu cha enzyme iyi ndikusintha methylglutaryl coenzyme A kukhala mevalonic acid, womwe ndi patsogolo pa cholesterol.

Atorvastatin imagwira maselo a chiwindi, kutsitsa kuchuluka kwa LDL ndi cholesterol kupanga. Amagwiritsidwa ntchito moyenera ndi odwala omwe ali ndi homozygous hypercholesterolemia, omwe sangathe kuthandizidwa ndimankhwala ena omwe amachepetsa cholesterol. Mphamvu yakuchepa kwa cholesterol ndende mwachindunji zimatengera mlingo wa chinthu chachikulu.

Atomax simalimbikitsidwa kuti imwedwa pakudya, monga kudya kumachepetsa kuchuluka kwa mayamwidwe. Chosakaniza chophatikizacho chimayamwa bwino m'mimba. Zambiri mwa atorvastatin zimawonedwa patatha maola 2 mutatha kugwiritsa ntchito.

Mothandizidwa ndi michere yapadera CY ndi CYP3A4, kagayidwe kamapezeka m'chiwindi, zomwe zimapangitsa kuti parahydroxylated metabolites ipangidwe. Kenako metabolites amachotsedwa m'thupi limodzi ndi bile.

Zizindikiro ndi contraindication ntchito mankhwala

Atomax imagwiritsidwa ntchito kutsitsa cholesterol. Dotolo amakupatsani mankhwala osakanikirana ndi zakudya zopezeka ndi matenda enaake monga matenda oyamba, achibale komanso achibale osagwirizana ndi a hypercholesterolemia.

Kugwiritsa ntchito mapiritsi kumathandizanso pakuwonjezera kuchuluka kwa seramu ya thyroglobulin (TG), pamene chithandizo chamankhwala sichimabweretsa zotsatira zomwe mukufuna.

Atorvastatin bwino amachepetsa cholesterol mwa odwala homozygous achiberekera hypercholesterolemia, pamene sanali mankhwala pharmacological ndi zakudya sakhazikitsa metabolid kagayidwe.

Atomax ndi yoletsedwa m'magulu ena a odwala. Malangizo omwe ali ndi mndandanda wa contraindication ogwiritsira ntchito mankhwalawa:

Ana ndi achinyamata ochepera zaka 18.
Nthawi yobereka mwana ndi kuyamwitsa.
Hepatic kukanika kwa komwe sikudziwika.
Hypersensitivity pazinthu zomwe zimapangidwa.

Mankhwala amathandizidwa mosamala ngati ochepa hypotension, kusagwirizana kwa ma elekitirodiya, vuto la endocrine, chiwindi cham'mimba, zakumwa zoledzeretsa komanso khunyu, zomwe sizingatheke.

Malangizo ogwiritsira ntchito mankhwalawa

Chofunikira pakuthandizira kwa Atomax ndiko kusunga zakudya zapadera. Chakudya chopatsa thanzi ndicholinga chofuna kuchepetsa zakudya zomwe zimakhala ndi cholesterol yayikulu. Chifukwa chake, chakudyacho sichimaphatikizapo kumwa kwa viscera (impso, ubongo), mazira a mazira, batala, mafuta a nkhumba, etc.

Mlingo wa atorvastatin umasiyana 10 mpaka 80 mg. Monga lamulo, adotolo amakupatsani mankhwala ochepa a 10 mg patsiku. Pali zinthu zingapo zomwe zimapangitsa kuchuluka kwa mankhwalawa, monga kuchuluka kwa LDL ndi cholesterol yathunthu, zolinga zamankhwala ndikuchita kwake.

Kuchulukitsa kwa mankhwalawa kumatha kuchitika pambuyo pa masiku 14 mpaka 14. Poterepa, kuphatikizira kwa lipids m'madzi amadzi amwazi kumakhala kofunikira.

Pambuyo masiku 14 chithandizo, kuchepa kwa cholesterol kumawonedwa, ndipo patatha masiku 28 pazotheka kwambiri achire. Ndi chithandizo chotenga nthawi yayitali, lipid metabolism imabweleranso.

Kukhazikitsa kwa mankhwalawa kuyenera kusungidwa pamalo otetezedwa kuti asayang'anitsidwe ndi dzuwa mwachindunji ndi ana aang'ono. Mphamvu yotentha yosungirako imasiyanasiyana madigiri 5 mpaka 20 Celsius.

Moyo wa alumali ndi zaka ziwiri, atatha nthawi imeneyi mankhwalawo saloledwa kumwa.

Zovuta Zoopsa komanso Mankhwala Osokoneza bongo

Kudzilamulira nokha kwa mankhwala osokoneza bongo ndi koletsedwa.

Nthawi zina, mankhwala amathandizanso wodwala kusintha.

Musanagwiritse ntchito Atomax, muyenera kufunsa dokotala.

Tsamba lophunzitsira limafotokoza za zotulukapo zoyipa izi:

Kusokonezeka kwa chapakati mantha dongosolo: asthenic syndrome, kugona tulo kapena kugona, kugona tulo, amnesia, chizungulire, kupweteka kwa mutu, kupsinjika, tinnitus, mavuto okhala pogona, paresthesia, zotumphukira neuropathy, kukoma kwa pakamwa.
Zochita zogwirizana ndi ziwalo zam'maganizo: Kukula kwa ugonthi, malo owuma a conjunctiva.
Mavuto a mtima ndi hematopoietic dongosolo: phlebitis, magazi m'thupi, angina pectoris, vasodilation, orthostatic hypotension, thrombocytopenia, kuchuluka kwa mtima, arrhasmia.
Kuwonongeka kwa kwam'mimba kokwanira ndi dongosolo la biliary: kudzimbidwa, kutsegula m'mimba, mseru, kusanza, kupweteka kwam'mimba, chiwindi colic, kuyimitsa, kutentha kwa mtima, kuwonjezeka kwa mpweya, kupweteka kwapakhosi.
Khungu limakhudza khungu: kuyabwa, zotupa, chikanga, kutupa kwa nkhope, mawonekedwe a dzuwa.
Mavuto a minofu ndi mafupa am'mimba: minofu kukokana kwa m'munsi, kupweteka kwa kuphatikizika kwa mafupa ndi msana, myositis, rhabdomyolysis, nyamakazi, kukokomeza kwa gout.
Kuchepetsa kukodza: Kuchepetsa kukodza, cystitis.
Kuzindikira kwa magawo a labotale: hematuria (magazi mkodzo), albuminuria (mapuloteni mu mkodzo).
Zina zomwe zimachitika: hyperthermia, kuchepa kwa chilakolako chogonana, kusokonekera kwa mankhusu, alopecia, thukuta kwambiri, seborrhea, stomatitis, kutaya magazi mkamwa, thumbo, ukazi ndi mphuno.

Kutenga Mlingo waukulu wa atorvastatin kumawonjezera chiopsezo cha kulephera kwa impso, komanso myopathy (neuromuscular matenda) ndi rhabdomyolysis (kwambiri degree of myopathy).

Mpaka pano, palibe mankhwala apadera a mankhwalawa.

Ngati zizindikiro za bongo zimachitika, ziyenera kuchotsedwa. Pankhaniyi, hemodialysis siyothandiza.

Kuchita ndi mankhwala ena

Zomwe zimagwiritsidwa ntchito ndi mankhwala zimatha kudzichitira mosiyanasiyana, chifukwa chomwe achire atomax angalimbikitsidwe kapena kufooka.

Kuthekera kwa kulumikizana pakati pazigawo zosiyanasiyana za mankhwala osiyanasiyana kumafuna kuti wodwalayo adziwitse adokotala za kumwa mankhwala omwe amakhudza ntchito ya Atomax.

Mu malangizo ogwiritsira ntchito mankhwala a hypolipidemic, mumakhala chidziwitso chokwanira pakukhudzana ndi mankhwala ena.

Mankhwala osakanikirana ndi cyclosporine, erythromycin, ma fibrate ndi ma antifungal agents (gulu la azoles) limawonjezera chiopsezo cha neuromuscular pathology - myopathy.
Popanga kafukufuku, kutumiza kwa munthawi yomweyo kwa Antipyrine sikumabweretsa kusintha kwakukulu mu pharmacokinetics. Chifukwa chake, kuphatikiza kwa mitundu iwiri ya mankhwala ndikuloledwa.
Kugwiritsanso ntchito komwe kuyimitsidwa komwe kumakhala ndi magnesium hydroxide kapena aluminium hydroxide kumabweretsa kuchepa kwa zomwe atorvastatin mu plasma.
Kuphatikizidwa kwa Atomax ndi mankhwala oletsa kubereka komwe kumakhala ndi kachilomboka ndi norethindrone kumawonjezera AUC pazinthu izi.
Kugwiritsa ntchito pamodzi nthawi yomweyo colestipol kumachepetsa kuchuluka kwa atorvastatin. Izi zimathandizanso kutsitsa kwa lipid.
Atomax imatha kuwonjezera digoxin m'magazi. Ngati ndi kotheka, chithandizo ndi mankhwalawa chiyenera kuyang'aniridwa ndi achipatala.
Kufanana kwa Azithromycin sikukhudza zomwe zimachitika mu Atomax m'magazi amwazi.
Kugwiritsidwa ntchito kwa erythromycin ndi clarithromycin kumapangitsa kuchuluka kwa atorvastatin m'magazi.
Panthawi yoyeserera pachipatala, panalibe mankhwala omwe adapezeka pakati pa Atomax ndi Cimetidine, Warfarin.
Kuwonjezeka kwa msika wogwira ntchito kumawonedwa ndi kuphatikiza kwa mankhwalawo ndi ma proteinase blockers.
Ngati ndi kotheka, dokotala amakulolani kuphatikiza Atomax ndi mankhwala, omwe akuphatikizapo Amplodipine.
Kafukufuku wokhudzana ndi momwe mankhwalawa amathandizira ndi antihypertensive mankhwala sanachitike.

Ndi kuphatikiza kwa Atomax ndi estrogens, palibe zoyipa zomwe zimawonedwa.

Mtengo, ndemanga ndi fanizo

Pali zambiri zazidziwitso pakugwiritsa ntchito Atomax pa intaneti. Chowonadi ndi chakuti pakali pano, ma IV a statins omwe amagwiritsidwa ntchito pochita zachipatala. Mankhwalawa amakhala ndi mlingo waukulu ndipo samayambitsa mavuto ambiri.

Atomax ndizovuta kugula m'masitolo am'dzikolo chifukwa choti tsopano siigwiritsidwe ntchito. Pafupifupi, mtengo wa phukusi (mapiritsi 30 a 10 mg) umachokera ku 385 mpaka 420 rubles. Ngati ndi kotheka, mankhwalawa atha kuitanidwa pa intaneti pa tsamba lovomerezeka la opanga.

Pali ndemanga zochepa pazomwe zimapangitsa kuti ma lipid azitsitsa pazosankha zawo. Nthawi zambiri, amalankhula za zomwe zimachitika ndikamamwa mankhwala. Komabe, pali malingaliro osiyanasiyana.

Chifukwa cha zovuta zosiyanasiyana komanso zovuta zina, nthawi zina dokotalayo amapereka mankhwala ofanana (mankhwala omwe ali ndi chinthu chomwechi) kapena analogue (yopangidwa ndi zigawo zosiyanasiyana, koma imatulutsa njira yofananira).

Maulumikizano otsatirawa a Atomax atha kugulidwa pamsika wogulitsa mankhwala ku Russia:

Atovastatin (No. 30 pa 10 mg - 125 rubles),
Atorvastatin-Teva (No. 30 kwa 10 mg - 105 ma ruble),
Atoris (No. 30 kwa 10 mg - 330 ma ruble),
Liprimar (No. 10 pa 10 mg - 198 rubles),
Novostat (No. 30 kwa 10 mg - 310 ma ruble),
Tulip (Na. 30 kwa 10 mg - 235 ma ruble),
Torvacard (No. 30 kwa 10 mg - 270 rubles).

Mwa mitundu yofananira ya Atomax, ndikofunikira kusiyanitsa mankhwalawa:

Akorta (No. 30 kwa 10 mg - 510 rubles),
Krestor (No. 7 kwa 10 mg - 670 rubles),
Mertenil (No. 30 kwa 10 mg - 540 rubles),
Rosuvastatin (No. 28 pa 10 mg - 405 rubles),
Simvastatin (No. 30 pa 10 mg - 155 rubles).

Popeza taphunzira mosamala mankhwala a Atomax, malangizo ogwiritsira ntchito, mtengo, analogi ndi lingaliro la ogula, wodwalayo, pamodzi ndi katswiri wopezekapo, atha kuwunika mozama za kufunika kwa kumwa mankhwalawo.

Zambiri zokhudzana ndi ma statins zimaperekedwa kanema munkhaniyi.