Glemaz: katundu wa mankhwala, mlingo, malangizo

Glemaz ndi mankhwala omwe ali m'gulu la mankhwala omwe amapezeka ndi sulfonylureas a m'badwo wachitatu.

Chidachi chimagwiritsidwa ntchito kuwongolera kuchuluka kwa shuga m'magazi pamaso pa wodwala yemwe ali ndi insulin-yodziyimira payokha ya shuga.

Glemaz amapangidwa ndi makampani opanga mankhwala mwanjira ya mapiritsi. Mapiritsi a Glemaz ali ndi mawonekedwe amizeremizere, mapangidwe atatu amawayika pansi.

Chofunikira chachikulu cha mankhwalawa ndi glimepiride. Kuphatikiza pazomwe zimagwira, mawonekedwe a mankhwalawa amaphatikizanso zinthu zina zomwe zimagwira ntchito yothandiza.

Zinthu zoterezi zomwe zidapangidwa ndi Glemaz ndi:

sodium croscarmellose,
cellulose
magnesium wakuba,
Chitin chikasu,
Utoto wonyezimira bwino,
MCC.

Piritsi limodzi lili ndi 4 mg yogwira ntchito.

Mankhwalawa amagwiritsidwa ntchito popanga onse a monotherapy komanso monga gawo limodzi la zovuta pochiza matenda a matenda a shuga 2.

Pharmacodynamics wa mankhwala Glemaz

Glimepiride, yomwe ndi gawo la miyala, imathandizira kubisalira komanso kuchotsedwa kwa insulin m'maselo a beta a minyewa ya m'mimba. Ndi chifukwa chake kuti pancreatic mphamvu ya yogwira ntchito imawonetsedwa.

Kuphatikiza apo, mankhwalawa amathandizira kusintha kwamtundu wa zotumphukira zotengera insulin - minofu ndi mafuta pazotsatira za insulin ya mahomoni pa iwo. Momwe mankhwala amapangira maselo a zotumphukira zomwe zimadalira insulin, mphamvu ya extrapancreatic ya mankhwala a Glymaz imawonetsedwa.

Malangizo a insulin secretion ndi sulfonylurea zotumphukira amakwaniritsidwa mwa kutseka njira zotengera potaziyamu za ATP mu cell membrane ya cell pancreatic beta. Kutsekera kwa njira kumatsogolera kukuwonongeka kwa maselo ndipo, chifukwa chake, kutsegulidwa kwa njira za calcium.

Kuwonjezeka kwa kuchuluka kwa calcium mkati mwa maselo kumabweretsa kutulutsidwa kwa insulin. Kutulutsidwa kwa insulin tikakumana ndi maselo a beta a zigawo za mankhwala Glymaz kumapangitsa kuti insulini isamasulidwe mosavuta, zomwe zimachepetsa kupezeka kwa hypoglycemia m'thupi la wodwala wokhala ndi matenda a shuga a 2.

The yogwira thunthu ali ndi linalake ndipo tikulephera mayendedwe a potaziyamu zimagwira mu nembanemba a mtima.

Glimepiride imawonjezera ntchito ya glycosylphosphatidylinositol yeniyeni phospholipase C. Glimepiride imathandizira kuletsa mapangidwe a shuga m'maselo a chiwindi. Njirayi imagwiridwa ndikuwonjezera kuchuluka kwa ndende ya fructose 1,6-bisphosphate. Pulogalamuyi imalepheretsa gluconeogeneis.