Liptonorm: mtengo wa mankhwalawo m'masitolo, zikuwonetsa ndi kuwunika

Mankhwala ochepetsetsa a lipid ndi a m'gululi ma statins. Makina ake ochitapo kanthu amatengera zoletsa za 3-hydroxy-3-methylglutarylcoenzyme A kapena HMG-CoA, komanso kuchepetsa. enzymezomwe zimathandizira njira yosinthira zinthu kukhala mevalonic acid. Kusintha kotere kumachitika kumayambiriro kwa kaphatikizidwe. cholesterol. Kugwiritsa ntchito mankhwalawa kumalepheretsa kupanga cholesterol ndipo kumachepetsa kwambiri zomwe zimapangidwa magazi.

Kuwonetsedwa kwa antisulinotic zotsatira za Liptonorm kumalumikizidwa ndi kukhudzidwa kwake pazitseko zamitsempha yamagazi ndi kapangidwe ka magazi. Nthawi yomweyo, kupanga isoprenoids, kukula kwa maselo mkati mwa membrane wamitsempha, kumachepetsa. Mankhwalawa amathandizanso endothelium - kudalira kwamitsempha yamagazi, kutsitsa cholesterol, triglycerides, kutsika kwa lipoproteins ndi apolipoprotein B. Kuwonjezeka kwa cholesterol ya HDL ndi apolipoprotein A kumadziwika.

Mankhwala amadziwika ndi kuyamwa kwambiri. Kuchuluka kwazinthu kumawonekera pambuyo pa maola 1-2 ndipo zimatengera jenda, kukhalapo kwa matenda osachiritsika, kudya, nthawi ya tsiku, ndi zina zambiri.

Liptonorm ili ndi systemic bioavailability yocheperako chifukwa cha pang'onopang'ono kagayidwe zimagwira pakatikati pa m'mimba thirakiti kudzera mu chiwindi. Mu thupi, mankhwalawa amasinthidwa kukhala angapo metabolites, kuchotsedwa kwa komwe ndi gawo la zinthu zosasinthika kumachitika ndi bile ndi mkodzo.

Zisonyezero zakugwiritsa ntchito Liptonorm

Mankhwala ndi mankhwala:

• hypercholesterolemia yoyamba,
• Hyperlipidemia
• wosanga ndi homozygous achibale hypercholesterolemia, monga chowonjezera chakudya.

Contraindication

Kugwiritsa ntchito mankhwala kumayikiridwa:

• kudziwa magawo ake,
• matenda a chiwindi ndi impso,
• kuyamwa, kutenga pakati,
• Odwala ali ochepera zaka 18.

Chenjerani pakufunika matenda osiyanasiyana a chiwindi, kusalinganika kwa electrolyte, kulephera kwina ndi ma metabolic, zakumwa zoledzeretsa, matenda owopsa, kugunda kwa mtima, kugwidwa kosalamulirika, kuvulala kwakukulu ndi ntchito.

Zotsatira zoyipa

Mankhwalawa ndi Liptonorm, zotsatira zoyipa zimatha kugwira zomwe zimayambitsa ntchito yamanjenje, mtima, kupuma, hematopoietic, genitourinary system, ziwalo zam'maganizo, ndi minofu ya mafupa.

Kupatuka kotere kumatha kuwonekera ndi zizindikiro: kusowa tulo, chizungulire, mutu, asthenic syndrome, general malaise, amblyopia, kulira m'makutu, kuuma kwa conjunctiva, zotupa m'maso, ugonthi, glaucomakupweteka pachifuwa bronchitis, rhinitis.

Nthawi zina odwala amakumana ndi zovuta zomwe zimawonekera pakhungu monga: alopecia, xerodermathukuta kwambirichikanga, seborrhea.

Thupi lawo siligwirizana. Khunguzotupa, kulumikizana dermatitis, urticaria ndi kuphwanya kwina.

Pa mayeso a labotale, ndizotheka kudziwa hyperglycemia, hypoglycemia, kuchuluka kwa serum creatine phosphokinase, albinuria.

Zochita zina zosayenera ndizakuti: kulemera, mastodynia, gynecomastia ndi kukula gout.

Liptonorm, malangizo ogwiritsira ntchito (Njira ndi Mlingo)

Asanayambe chithandizo ndi mankhwalawa, wodwalayo ayenera kusamutsidwa chakudya, zomwe zimapereka kuchepa kwa zomwe zili lipids m'magazi. Kutsatira kwambiri zakudya zomwe zakhazikitsidwa zikufunika nthawi yonse ya mankhwala.

Malinga ndi malangizo, mapiritsi a Liptonorm amatengedwa pakamwa, mosasamala kanthu za kudya ndi nthawi ya tsiku, koma paola.

Ndikulimbikitsidwa kuyamba mankhwalawa ndi mlingo wa 10 mg wa kumwa tsiku lililonse. Pakapita kanthawi, kusankha kwa mankhwalawa kumachitika payekhapayekha, poganizira mawonekedwe a thupi la wodwalayo komanso zomwe zili mu cholesterol. Kusintha kwa mankhwalawa sikungatheke kuposa nthawi 1 pamwezi. Mlingo wovomerezeka tsiku lililonse ndi 80 mg.

Bongo

Mu nkhani ya bongo, zizindikiro zokhudzana ndi zovuta zimayamba, koma kwambiri.

Zapadera mankhwala chifukwa mankhwalawa mulibe, motero, mawonekedwe a chithandizo amachitika, njira zimayendetsedwa kuti zithandizire ntchito zofunikira za ziwalo ndikuletsa kuperewera kwa mankhwalawa mwachitsanzo, kupweteka kwam'mimba, kugwiritsa ntchitokaboni yodziyambitsa. Nthawi yomweyo hemodialysis sizikuwonetsa kuchita bwino.

Kuchita

Ngati munthawi yomweyo ndi mankhwala zotchulidwa Cyclosporine, Fibates, Erythromycin, Clarithromycin,NikotinamidePopeza mankhwala a immunosuppressive ndi antifungal ndi azoles, kuwonjezereka kwa kuchuluka kwa zinthu zake zogwira ntchito kungayembekezeredwe - atorvastatinmu kapangidwe magazi a m'magazi.

Kuphatikizidwa kwa atorvastatin ndi ma antacid, proteinase inhibitors, ndiye kuti, zoletsa za cytochrome P450 CYP3A4, zitha kuwonjezera kuchuluka kwa mankhwalawa m'madzi a m'magazi.

Kugwiritsa ntchito mankhwala ndi Digoxin kumawonjezera chidwi chake mthupi, komanso njira zakulera zamkamwa, zomwe zimaphatikizapo norethindronendi ethinyl estradiol.

Colestipol kumawonjezera kutsitsa kwa lipid, ndipo Warfarin itha kuchepetsa prothrombin nthawi koyambirira kwa chithandizo, chomwe chimafuna kuwunikira chizindikiritso ichi.

Kugwiritsa ntchito madzi a mphesa kumatha kukulitsa kuchuluka kwa atorvastatin panthawi ya mankhwala, chifukwa chake muyenera kukana.

Kutulutsa mawonekedwe ndi kapangidwe kake

Fomu ya Mlingo - mapiritsi okhala ndi mbali: ozungulira, ofukula mbali zonse, zoyera, pakhungu - pafupifupi loyera kapena loyera (ma PC 14. Mu chithuza, matuza awiri mu bokosi la makatoni).

Zogwira ntchito: atorvastatin (mwanjira ya mchere wa calcium), zomwe zili mu piritsi limodzi ndi 10 kapena 20 mg.

Zothandiza: pakati pa 80, lactose, hydroxypropyl cellulose, microcrystalline cellulose, croscarmellose, calcium carbonate, magnesium stearate, polyethylene glycol, titanium dioxide, hydroxypropyl methyl cellulose.

Malangizo ogwiritsira ntchito Liptonorm: njira ndi mlingo

Asanapereke mankhwala, wodwalayo amasamutsidwa zakudya zoyenera, zomwe zimatsimikizira kuchepa kwa magazi lipids (iyenera kuchitika nthawi yonse ya chithandizo).

Malinga ndi malangizo, Liptonorm iyenera kumwa pakamwa kamodzi pa tsiku, mosasamala za kudya, koma nthawi yomweyo tsiku lililonse.

Mlingo woyambayo nthawi zambiri umakhala 10 mg. M'tsogolomu, mulingo woyenera kwambiri amasankhidwa payekhapayekha, potengera zomwe zimakhala zochepa za lipoprotein cholesterol, kuopsa kwa matendawa komanso kugwiritsa ntchito bwino mankhwala. Mlingo uyenera kusinthidwa osachepera milungu 4.

Mulingo wovomerezeka tsiku lililonse ndi 80 mg mu 1 mlingo.

Zotsatira zoyipa

Kuchulukana kwa mavuto: kawirikawiri - pazochitika zopitilira 2%, kawirikawiri - mochepera 2% ya milandu.

• Pakati mantha dongosolo: Nthawi zambiri chizungulire ndi kusowa tulo, kusowa tulo, zolakwika, asthenic syndrome, zotupa, kupsyinjika, paresthesia, malaise, kusazindikira, kupweteka mutu, kupsinjika, amnesia, ataxia, hypnothesia, ziwalo zam'maso, zotumphukira neuropathy
• Ziwalo zomvera: kusokonezeka kwa malo okhala, kupotoza kukoma, kuwononga kukoma, parosmia (kutaya kununkhira), tinnitus, ugonthi, amblyopia, conjunctiva, glaucoma, kukha magazi kwa diso.
• Matenda a mtima: pafupipafupi - kupweteka pachifuwa, kawirikawiri - migraine, kuchuluka kwa kuthamanga kwa magazi, vasodilation, arrhythmia, postural hypotension, angina pectoris, palpitations, phlebitis,
• Njira yothandizira kupumira: kawirikawiri - matenda a brinchitis ndi bronchitis, kawirikawiri - dyspnea, nosebleeds, mphumu ya bronchial, chibayo,
• Matumbo: Nthawi zambiri - cheilitis, stomatitis, pakamwa pouma, kutulutsa magazi, zotupa ndi zotupa zamkamwa, kupweteka kwam'mimba, kupweteka kwam'mimba, kupweteka kwapakhosi, kupweteka, mseru, kudzimbidwa kapena kutsegula m'mimba, kudya m'mimba kapena kuchuluka kwa chilala, gastralgia, melena, kusanza, dysphagia, gastroenteritis, esophagitis, tenesmus, kapamba, duodenal zilonda, chiwindi colic, kusokonezeka kwa chiwindi, hepatitis, cholestatic jaundice, magazi a rectal,
• Matenda a minofu ndi mafupa: Nthawi zambiri nyamakazi, kawirikawiri bursitis, kukokana kwa minyewa, myopathy, myositis, arthralgia, torticollis, mgwirizano wophatikizika, tendosynovitis, minofu hypertonicity, myalgia, rhabdomyolysis,
• Hematopoietic dongosolo: lymphadenopathy, anemia, thrombocytopenia,
• Genitourinary system: Nthawi zambiri - zotumphukira edema, matenda a urogenital, kawirikawiri - dysuria (kuphatikizapo kwamikodzo posungira kapena kwamikodzo, nocturia, kufunikira kwamkodzo, polakiuria), nephrourolithiasis, hematuria, nephritis, epididymitis, metrorrhagia umuna, kuchepa kwa libido, kusabala,
• Dermatological zimachitika: Nthawi zambiri - thukuta lakuchulukirachulukira, xeroderma, chikanga, ecchymosis, seborrhea, petechiae, alopecia,
• Thupi lawo siligwirizana: pafupipafupi - kukhudzana ndi dermatitis, zotupa pakhungu, kuyabwa, kawirikawiri - kutupa kwamaso, anaphylaxis, angioedema, urticaria, photosensitivity, Stevens-Johnson syndrome, erythema multiforme, poyizoni epermermal necrolysis,
• Zowonetsa zasayansi: kawirikawiri - albinuria, hypoglycemia, hyperglycemia, kuchuluka kwa alkaline phosphatase, serum creatine phosphokinase, alanine aminotransferase (ALT) ndi aspartate aminotransferase (AST),
• Zina: kawirikawiri - kunenepa kwambiri, kuchulukitsa kwa gout, mastodynia, gynecomastia.

Chifukwa chiyani Liptonorm imayikidwa ngati mitsempha ya varicose?

Anthu nthawi zambiri amakhala ndi vuto la mtima. Kuti awathetse, chithandizo chovuta chimalembedwa, chomwe chimaphatikizapo kumwa mankhwala. Kusunga zotsatira zomwe mumapeza mukamalandira chithandizo ndikugwiritsa ntchito Liptonorm.

Kugwiritsa ntchito Liptonorm kuthandizira zotsatira zomwe zimapezeka pochizira mtima.

Mapulogalamu zochita za Liptonorm

Mankhwalawa amatengedwa kuti achepetse kuchuluka kwa lipoproteins ochepa.

The pazipita kuchuluka kwa mankhwala Liptonorm m'magazi amati 1-2 mawola kumwa mapiritsi.

Chifukwa cha iwo, pali kuphwanya kayendedwe ka magazi ndi kuchepetsedwa kwa lumen ya ziwiya, chifukwa cha kuyika kwamphamvu kwamafuta pakhoma. Mankhwalawa amachepetsa zomwe zili m'mapazi am'magazi, chifukwa chake, zimathandiza kupewa kukula kwa stroko, myocardial infarction ndi zovuta zina.

Kumwa mankhwalawa kumathandizira kupangika kwa magazi ndi kukonza mkhalidwe wamakoma amitsempha yamagazi kuchokera mkati.

Chipangizocho chili ndi antiproliferative ndi antioxidant. Ubwino wake wagona pakukhudza kwake cholesterol mwa odwala omwe ali ndi majini.

Kuyamwa kwa mankhwalawa kumachitika kudzera m'makoma a ziwalo zam'mimba. Pazambiri zomwe zimagwiritsidwa ntchito m'magazi zimawonedwa patatha maola 1-2 mutamwa mapiritsi. Zotsatira zamankhwala zimatha maola 20-30. Zinthu zambiri zimapakidwa mu ndulu, kuchuluka - mkodzo.

Ambiri mwa mankhwalawa amachotsedwa mu ndulu, kuchuluka - mkodzo.

Kugwiritsa

Asanayambe chithandizo, wodwalayo asinthana ndi zakudya, chifukwa momwe mankhwalawa a lipids mu plasma amachepa. Zakudyazo ziyenera kuchitika nthawi yonse yomwe mumamwa mankhwalawa. Wodwala ayenera kugwiritsa ntchito mankhwalawa tsiku lililonse piritsi limodzi nthawi imodzi, mosasamala za kudya. Mlingo woyambayo ndi 10 mg.

Itha kusinthidwa kutengera umunthu wa wodwalayo, kuopsa kwa matenda ake komanso momwe akusinthira mafuta. Mlingo wololedwa kusintha nthawi imodzi mu masabata anayi. Kuchuluka kwa mankhwala patsiku sayenera kupitirira 80 mg.

Asanayambe chithandizo ndi Liptonorm, wodwalayo ayenera kusinthana ndi zakudya zomwe zimathandizira kuchepetsa lipids ya plasma.

Malangizo apadera

Zambiri pazokhudzana ndi mankhwala ochepetsa mphamvu ya lipid sizipezeka. Pa chithandizo, muyenera kuyeserera pafupipafupi ndikuwona momwe ziwalo zonse zimagwirira ntchito.

Mavuto akachitika, chithandizo chakuletsa.

Kugwiritsira ntchito nthawi yomweyo mowa ndi mankhwala osokoneza bongo kungabweretse mavuto.

Kugwiritsira ntchito nthawi yomweyo mowa ndi Liptonorm kumatha kubweretsa zotsatirapo zoyipa.

Kuyanjana kwa mankhwala osokoneza bongo

Kuwonjezeka kwa milingo ya plasma ya atorvastatin kumachitika chifukwa cha munthawi yomweyo makonzedwe a immunosuppressant, cyclosporins, antifungal mankhwala, erythromycin, clarithromycin, ndi proteinase inhibitors.

Kuwonjezeka kwa Liptonorm m'madzi am'magazi kumachitika chifukwa cha kayendetsedwe kake ka nthawi imodzi ndi Erythromycin.

Chithandizo chimakhala chothandiza kwambiri ngati mugwiritsa ntchito mankhwalawa ndi Colestipol limodzi. Zomwe zimagwiritsidwa ntchito zimawonjezera kuchuluka kwa digoxin mukamamwa nthawi yomweyo.

Mankhwala Okhala Pamalo a Pharmacy

Mankhwalawa atha kugulidwa ku pharmac iliyonse ngati pali mankhwala kuchokera kwa katswiri.

Mtengo wa chida ichi umadalira mitengo yamapulogalamu ndi ma 238 rubles.

Ngati ndi kotheka, mankhwalawa amaloŵedwa ndi mankhwala ofananawo:

• Lipoford
• Atomu
• Vazator,
• Thorvakard
• Atorvastatin,
• Anvistatom,
• Atocord.

Dokotala amasankha ndalamazo. Pofuna kuti pasakhale zovuta zaumoyo, sizikulimbikitsidwa kuti musinthe moyenera mankhwalawa.

Mikhail, wazaka 35, Stavropol: “Ndidagwiritsa ntchito Liptonorm pamene mayesowo adawonetsa cholesterol yokwera m'magazi. Panalibe zotsatirapo zoyipa, komanso maubwino azithandizo. Adotolo adatenga analog yomwe idakhala yothandiza kwambiri. Ndawononga ndalama pachabe, sindikukulimbikitsani kuti ndizitenga. ”

A Angelina, azaka 47, ku Moscow: “Ndakhala ndikulimbana ndi mitsempha yayitali kwa nthawi yayitali. Mankhwalawa adalembera zochizira matendawa. Tsiku loyamba linali nseru, koma kenako zonse zinapita. Ndinachotsa zisonyezo zosasangalatsa, komanso kulemera m'miyendo yanga. Mtengo wakevomerezeka kwa ine. Panalibe mavuto. Ndimalimbikitsa aliyense chifukwa chithandizochi ndi chothandiza. ”

Varvara, wazaka 33, Krasnoyarsk: “Kukhala ndi pakati kwayamba chifukwa cha kunenepa kwambiri komanso mitsempha ya varicose. Dotolo adandiuza mankhwalawa, koma izi zisanachitike, kwa mwezi umodzi ndidatsata zakudya zomwe katswiri adatenga. Kutopa, kukhumudwa, ndi kupweteka m'miyendo kunatha patatha masabata awiri atatha kumwa koyamba. Zotsatira zoyipa za thupi sizinawonedwe. Chida chake ndichothandiza, ngakhale kuti zotsatira zake zimafunika kudikirira. "

Stanislav, wazaka 53, Yaroslavl: "" Mavuto a mtima wam'mimba adayambitsa kufunikira kwa chithandizo chovuta. Kutalika kwa mankhwalawa kunali pafupifupi mwezi. Pali zovuta zambiri, koma sindinadziwe. Mankhwalawa ndi okwera mtengo, ndipo amatha kuonekera patatha masiku angapo atavomerezedwa. ”

Liptonorm - mankhwala othandiza kuchepetsa lipid

Liptonorm ndi amodzi mwa mankhwala ochepetsa lipid. Chofunikira chachikulu ndicho gawo la atorvastatin, zomwe zimalepheretsa ntchito ya reductase.

Izi zimadziwika chifukwa cha gawo loyambirira la cholesterol synthesis m'thupi, ndipo Liptonorm imalepheretsa izi, chifukwa chomwe cholesterol m'magazi amatsika.

Zogulitsa

Mukamagwiritsidwa ntchito mkati, kuyamwa kwa Liptonorm kumakhala kwakukulu. Kupambana kwakukulu m'magazi ndi pambuyo pa maola awiri. Kudya pang'ono kumachepetsa nthawi komanso kuthamanga kwa zinthu zazikuluzikulu - atorvastatin (kuchokera 25% mpaka 9%).

Ubwenzi wapakati pa mlingo wa mankhwalawo ndi kuchuluka kwa mayamwidwe walembedwa.

Kupenda

Metabolism imachitika makamaka m'chiwindi ndikugwira nawo mwachangu ma isoenzymes ndikupanga metabolites.

Mphamvu yoletsa kukonzekera ya Liptonorm pafupifupi 65-75% imatsimikiziridwa ndi zochitika za metabolites ndipo imatha kukhala mpaka maola 30.

Hafu ya moyo ndi maola 15. Amachotsekedwa pambuyo pa mapangidwe a hepatic metabolic ndi bile, ndipo ochepera 2% ya mlingo wovomerezeka amatsimikiza mu mkodzo.

Atorvastatin sangathe kufufuzidwa panthawi ya hemodialysis.

5. Njira ya makonzedwe ndi kumwa mankhwala

Asanayambe mankhwala a Liptonorm, wodwalayo amalimbikitsidwa kuti asamutsidwe ku zakudya zapadera, zomwe zimapangitsa kuchepa kwa magazi lipids.

Mankhwalawa amayenera kumwa pakamwa kamodzi patsiku, chofunikira ndikugwiritsa ntchito nthawi yomweyo. Kudya sikukhudza mankhwala.

Mlingo woyenera wothandizidwa ndi 10 mg, mtsogolomu, mankhwalawa amasankhidwa malinga ndi zomwe amapezeka m'magazi a cholesterol aliyense payekhapayekha.

Chifukwa cha kuchotsedwa kwapang'onopang'ono kwa atorvastatin m'thupi, Liptonorm iyenera kugwiritsidwa ntchito mosamala odwala omwe ali ndi vuto la chiwindi.

Malangizo ogwiritsira ntchito Liptonorm, analogi ndi ndemanga

Popewa kuchuluka kwa cholesterol, muyenera kukhala ndi moyo wathanzi. Kwa iwo omwe kupewa sikokwanira, madokotala amapanga mankhwalawa Liptonorm.

Ndi gawo la gulu la ma statins omwe amayambitsa kusintha kwamphamvu mwa kuletsa ntchito ya michere ya chiwindi. Izi zimabweretsa kuchepa kwa intracellular cholesterol concentration and activation of LDL receptors. Zotsatira zake, kuwonongeka kwa cholesterol yoyipa imathandizira, koma osati kuwononga "zabwino".

Mankhwalawa amagulitsidwa ndi mankhwala, mtengo wa Liptonorm umasiyanasiyana m'malo a ma ruble a 180-350. kunyamula.

Liptonorm imagwiritsidwa ntchito pochiza:

1. Hypercholesterolemia yoyamba,
2. Hetero- ndi homozygous cholowa hypercholesterolemia (kuphatikizapo zakudya)
3. Hyperlipidemia wosakanikirana.

Tchati chantchito

Malangizo ogwiritsira ntchito Liptonorm akuwonetsa kuti choyamba muyenera kusinthana ndi zakudya. Cholinga chake ndikuchepetsa mulingo wa lipids m'mwazi mpaka mulingo wina. Zakudyazi ziyenera kusungidwa mpaka kumaliza kwa njira yothandizira achire.

Mankhwalawa amayenera kuledzera kamodzi patsiku panthawi yodziwika, mosasamala chakudya. Mlingo wa zoyambira ndi 10 mg (wotengedwa nthawi imodzi). Ndipo, ngati kuli kotheka, dokotalayo amasintha mlingo wa tsiku ndi tsiku, kuwunika zomwe zili mu LDL m'magazi, koma izi sizingachitike mopitilira nthawi imodzi m'milungu inayi. Mlingo wovomerezeka wambiri patsiku ndi 80 mg.

Malangizo a Liptonorm amasonyezanso kuti ngati chiwindi chayamba kugwira ntchito, kuchuluka kwa mankhwalawa kumachepetsa, motero dokotala amayenera kuyang'anira momwe thupilo limayendera.

Ngati masinthidwe akulu a pathological apezeka, mlingo wake umachepetsedwa kapena chithandizo chake chimayimitsidwa.

Kupanga ndi mawonekedwe a kumasulidwa

Liptonorm ndi piritsi lomwe lili ndi chipolopolo cha 10 ndi 20 mg. Maonekedwe ake ndi oyera, ozungulira komanso opindika kumbali iliyonse.
Zomwe zimagwira ndi atorvastatin. Zothandiza ndi calcium carbonate, Pakati pa 80, hydroxypropyl cellulose, cellulose microcrystals, magnesium stearate, lactose, croscarmellose, titanium dioxide ndi polyethylene glycol.

Zotsatira zoyipa

Wopanga Liptonorm akuchenjeza kuti zotsatira zosayenerera zimatha kukhudza ziwalo zosiyanasiyana.

Zotsatira zoyipa zomwe zimagwirizanitsidwa ndi ziwalo zam'maganizo:

• Kukulira m'makutu
• Kutupa m'maso,
• Zosintha pa kukoma (mpaka pakuwonongeka)
• Glaucoma
• Mutu
• Kusokoneza malo okhala,
• Parosmia,
• Kuuma kwa conjunctiva.

Zotsatira zoyipa zamagetsi zamkati siziperekedwa. Zina mwa izo ndi:

• Kusowa tulo
• Kugona
• Kuchepetsa kukumbukira
• Paresthesia
• Kusakhazikika pamalingaliro ndi kukhumudwa,
• Asthenia
• Peripheral neuropathy,
• Kufa ziwalo
• Hyperkinesis
• Zochita usiku
• Ataxia
• Kukhumudwitsa.

Odwala ena amakumana ndi mavuto a mtima ndi mitsempha yamagazi. Ali ndi zizindikiro monga:

• Ululu kumbuyo kwa sternum
• Kusweka mtima
• Kupsinjika kapena kutsika,
• Vasodilation
• Phlebitis
• Migraines
• Angina pectoris,
• Arrhasmia.

Pali chiopsezo cha magazi osakhazikika, ophatikizika:

Mavuto am'magazi oyipa:

• Kusanza ndi kusanza
• Kudzimbidwa kapena kutsegula m'mimba
• Hepatic colic,
• Kupweteka kwam'mimba komanso kutulutsa
• Chilala
• Glossitis
• Kutsekemera kwa mano
• Gastralgia
• Cholestatic jaundice,
• Stomatitis
• Cheilit,
• Kutentha kwamphesa ndi malamba
• Kuuma, kukokoloka, ndi zilonda zamkamwa,
• Hepatitis
• Gastroenteritis
• Zilonda za Duodenal,
• Pancreatitis
• Dysphagia
• Kutuluka magazi.

Zotsatira zoyipa za gawo la genitourinary nthawi zina zimawonedwa:

• Peripheral edema,
• Yade
• Matenda a urogenital
• Dysuria (kuphatikizapo posungira komanso kukodzetsa kwamikodzo),
• Kutupa kwa magazi
• Kuchepetsa kugonana
• Matenda okoka
• Kulephera.

Zotheka dermatological zimachitika:

• Kusalala ndi dazi,
• Kutukwana
• Eczema
• Xeroderma,
• Acchymoses,
• Petechiae.

Zotsatira zoyipa za dongosolo la musculoskeletal:

• Nyamakazi
• Khalidkalil,
• Myositis
• Zingwe
• Myalgia
• Minofu hypertonicity,
• Myopathy
• Tenosynovitis
• Bursitis
• Kuphatikizana kwapakati.

Pali zodandaula za thupi lawo siligwirizana:

• Khungu loyera
• Zotupa pakhungu
• Lumikizanani ndi dermatitis,
• Kutupa kwa nkhope
• Urticaria
• Edema ya Quincke ndi anaphylactic,
• Zithunzi,
• Lyell ndi Stevens-Johnson Syndromes
• Erythema multiforme.

Zotsatira zoyipa zomwe zimakhudzana ndi kupuma:

• Rhinitis
• Bronchitis
• Mphumu ya bronchial,
• Chibayo
• Zamphuno
• Dyspnoea

Pali mwayi wopanga mastodynia, gynecomastia, kuchuluka kwa gout ndi kunenepa kwambiri.

Osakwana 2% ya odwala, magawo a labotale amasintha ndipo amalembedwa:

• Alkaline phosphatase
• Kuchulukitsa seramu ALT ndi kupanga phosphokinase,
• Hyper- ndi hypoglycemia,
• Albuminuria

Liptonorm: malangizo ogwiritsira ntchito, analogi, kuchenjeza, ndemanga

Liptonorm ndi mankhwala omwe amalembera okhathamira kwambiri wa cholesterol. Kuchulukitsa cholesterol kumabweretsa zotsatirapo zosiyanasiyana zosasangalatsa, chimodzi mwazowopsa zomwe ndi atherosulinosis.

Mankhwalawa ndi a statins, chifukwa chake madokotala amamulembera mosamala kwambiri. Asanatenge Liptonorm, wodwalayo ayenera kuphunzira malangizo ogwiritsira ntchito, mitengo, malingaliro.

(!) Mankhwala siziyenera kusokonezedwa ndi zakudya zowonjezera Liponorm. Mankhwala ndi zowonjezera zowonjezera pazakudya ndi zosiyana ziwiri, osati zogwirizana.

Mawonekedwe ndi kipimo

Chofunikira chachikulu cha Liptonorm ndi calcium ya calcium ya Atorvastatin. Mwa zina zake zothandiza ndi monga:

• calcium carbonate
• Zaka 80,
• MCC
• zakudya zowonjezera E463 ndi E572,
• sodium croscarmellose,
• lactose
• madzi oyeretsedwa.

Liptonorm amapangidwa piritsi. Mapiritsi ophatikizidwa a 10 mg kapena 20 mg amapezeka mu kuchuluka kwa 7, 10, 14, 20, 28 kapena 30 ma PC.

Gwiritsani ntchito pa nthawi yoyembekezera

Zomwe zimagwiritsidwa ntchito ndi mankhwalawa ndizoletsedwa kwa odwala panthawi yoyembekezera komanso nthawi yoyamwitsa (yoyamwitsa) chifukwa cha zotsatira zoyipa za thupi la mwana wakhanda. Ngati wodwala akukonzekera kutenga pakati, ndibwino kumusiya kwa miyezi ingapo. Amayi pa nthawi ya mankhwalawa ndi Liptonorm sayenera kunyalanyaza kulera.

Zovuta zina zimaphatikizapo ubwana ndi unyamata. Zambiri pokhudzana ndi chithandizo cha ana ndi mankhwala mpaka pano sizikupezeka.

Mtengo wa mankhwala

Mtengo wa mankhwala Liptonorm umatsimikiziridwa ndi njira zingapo - kuchuluka kwa matuza mu phukusi, mlingo, ndi zina. Pafupifupi, mapiritsi 10 mg angagulidwe ku mankhwala a 200-250 rubles. Mtengo wa paketi 28 ma PC. 20 mg iliyonse ndi ma ruble 400-500.

Ku Ukraine, mtengo wamankhwala pamtengo wa 20 mg ndi 250-400 UAH.

Analogs Liptonorm

Ngakhale kuti Liptonorm ndi mankhwala othandiza kwambiri, siabwino kwa odwala onse. Hypersensitivity kwa gawo lina la mankhwalawa ndikupangidwadi ndi zifukwa ziwiri zazikulu zosinthira ndi analogue yotsika mtengo.

Mankhwala otsatirawa ndi amodzi mwa fanizo la Liptonorm:

• Atorvastatin
• Atorvastatin-Teva,
• Torvacard
• Liprimar
• Atoris
• Vazator.

Kugwiritsa Ntchito

Ndemanga ya momwe amagwiritsidwira ntchito akuwonetsa kuti madokotala nthawi zambiri amamulembera wodwalayo popanda kuwafotokozera mwatsatanetsatane za mawonekedwe ake ndi njira zake zoyipa.

Tamara, Moscow: "M'masiku oyamba kumwa mapiritsi, ndinayamba kumva kupweteka m'mimba mwanga, ndikung'ung'udza m'mimba mwanga, ndipo masiku angapo pambuyo pake - nseru ndi kusanza. Sindinaphatikizepo mwanjira iliyonse mawonetsedwe awa ndi kutenga Liptonorm.

Popeza ndakhala ndikuvutika ndi matenda am'mimba kuyambira ndili mwana ndikusintha pang'ono pazakudya zanga, nthawi yomweyo ndidatembenukira kwa dokotala wa gastroenterologist. Chifukwa cha adotolo, ndazindikira zomwe zidayambitsa kusokonezeka m'mimba, komabe ndimasamala za funsoli.

Chifukwa chiyani wondyang'anira zakudya samandiwchenjeza za zotsatira zake? "

Ekaterina, Novosibirsk: “Kulemera kwambiri kwandipitilira kuyambira ndili mwana, koma nditakwanitsa zaka 30 ndinasankha kudzisamalira ndikudziwa chomwe chayambitsa vuto langali. Kafukufuku wa Laborator awonetsa kuti choyambitsa ndi cholesterol yayikulu ndipo wondithandizira adandipatsa Liptonorm.

Patsiku loyamba, kuthamanga kwa magazi kwanga kudakwera kufika pa 150. Tsiku lotsatira m'mawa kupanikizika kunali kwachilendo, koma pambuyo pa nkhomaliro adalumphanso mpaka 160. Pambuyo pake ndidaganiza zowerenga malangizowo ndipo pomaliza ndidamvetsetsa zomwe zimachitika. Kuthamanga kwa magazi ndi zotsatira zamankhwala.

Kupanikizika kunasiya masiku 5 atangoyamba kumene chithandizo chamankhwala. ”

Kuwunikira ndemanga zonse pamwambapa pa kugwiritsa ntchito mapiritsi a Liptonorm, akuyenera kudziwa kuti ndikofunikira kukaonana ndi dokotala musanagwiritse ntchito.

Choyamba, zimachitika chifukwa chakuti mankhwalawo ndi a gulu la ma statins omwe angalimbane ndi kuchuluka kwa mafuta m'thupi.

Monga mukudziwira, kuikidwa kapena kuthetsedwa kwa wothandizira aliyense wa mahomoni kumatha kuchitika ndi katswiri.

Kachiwiri, mankhwalawa ali ndi zotsutsana zosiyanasiyana komanso zoyipa kuchokera m'matumbo am'mimba, chapakati chamanjenje, mtima ndi zina zofunika kachitidwe. Katswiriyu akuyenera kupereka mankhwala, afotokozere zomwe zikuchitika, ndikuwuzanso wodwalayo za zovuta zomwe zingachitike.

Liptonorm: mtengo wa mankhwalawo m'masitolo, zikuwonetsa ndi kuwunika

Liptonorm (liptonorm) - mankhwala ochokera ku gulu la ma statins, amagwiritsidwa ntchito kutsitsa cholesterol yamagazi. Zinthu zomwe zimagwiritsidwa ntchito ndi mankhwala zimalepheretsa kupanga isoprenoids, zimathandizira kukulitsa kwamitsempha yamagazi.

Mankhwala otsika triglycerides, otsika kachulukidwe kolesterol, kumawonjezera zomwe zili ndi mafuta osalimba ngati zinthu, polypoprotein A. Nthawi zambiri, wodwala matenda ashuga amadzazindikira mphamvu ya mankhwalawa patatha masiku 14 chiyambireni chithandizo, pakatha masabata anayi ayenera kupitilira kuchuluka kwake.

Mankhwalawa samayikidwa kwambiri hepatic ndi matumbo, ndipo amachotsedwa m'thupi limodzi ndi bile. Hafu ya moyo ndi maola 14. Chifukwa cha kukhalapo kwa metabolites yogwira, mphamvu ya inhibitory imatha maola 20 mpaka 30. Pa hemodialysis, mankhwalawa samachotsedwa, osakwana 2% ya mlingo wovomerezeka amapezeka mu mkodzo.

Zisonyezero zogwiritsidwa ntchito zimaphatikizidwa hyperlipidemia, hypercholesterolemia, heterozygous ndi homozygous achibale hypercholesterolemia.

Mtengo wa mankhwala Liptonorm m'masitolo ndi ma ruble 190, mutha kugula popanda kuuzidwa ndi dokotala.

Malangizo ogwiritsira ntchito mankhwalawa

Musanapereke mankhwala, tikulimbikitsidwa kusinthana ndi chakudya choyenera chomwe chimapereka cholesterol yotsika m'magazi. Zakudya zimamatira nthawi yonse ya chithandizo.

Maupangiri othandizira amalimbikitsa kumwa piritsi limodzi la mankhwalawa patsiku, nthawi yakudya siziwathandiza, koma mankhwalawa amayenera kumwa nthawi yomweyo. Mlingo woyambirira wa munthu wodwala matenda ashuga ndi 10 mg ya chinthucho, mtsogolomo kuchuluka kwa mankhwalawa kumasankhidwa payekha.

Mlingo wa mankhwalawa umatengera kuchuluka kwa cholesterol yotsika, kuopsa kwa njira ya pathological, kugwiritsa ntchito bwino kwa mankhwala ambiri. Kusintha kwa dose kumapangidwa pakatha milungu 4.

Mankhwala okwanira 80 mg amatha kumwa patsiku.

Mitu ya mankhwalawa

Ngati Liptonorm sioyenera pazifukwa zilizonse, dokotala amamufotokozera. Otchuka kwambiri aiwo adakhala: Aterocardium, Lipona, Torvakard, Atorvastatin, Anvistat, Atomaks, Liprimar.

Mtengo wa mankhwalawa umatengera wopanga, chifukwa mapiritsi a Liptonorm mtengo ndiwotsika mtengo.

Zambiri zokhudzana ndi ma statins zimaperekedwa kanema munkhaniyi.

Sonyezani shuga lanu kapena sankhani jenda pamayendedwe Kusaka OsapezekaKusaka Kuyang'ana kosapezeka

Ndemanga za madokotala za liponorm

Mankhwala "Liptonorm" amayimilira pazida zabwino zomwe madokotala a akatswiri amatsenga ndi ma gastroenterologists amapanga.

Mtengo ukhoza kutsika. Mankhwala abwino ayenera kukhala okwera mtengo.

Monga lamulo, amaperekedwa kwa odwala omwe ali ndi cholesterol yayikulu pakuwunika. Kuwunika ndi kupitiliza kuthandizira mankhwalawa. Zimadziwonetsa bwino mu mankhwala othandiza.

Ndi chiwindi ntchito

Mankhwala amatchulidwa mosamala pamaso pa mbiri ya matenda a chiwindi.

Liptonorm imatsutsana pazochitika zotsatirazi:

• gawo la matenda a chiwindi (mwachitsanzo, ndi hepatitis yayitali, matenda oopsa a chiwindi),
• kuchuluka kwa hepatic transaminases (wopitilira malire okwera kwambiri mwa zinthu zosachepera katatu poyerekeza ndi VGN) a etiology osadziwika,
• matenda a chiwindi osiyanasiyana etiologies,
• kulephera kwa chiwindi (Maphunziro a ana-Pugh A ndi B).

Mtengo wa Liptonorm m'masitolo ogulitsa mankhwala

Mtengo wokumanga wa Liptonorm 10 mg wa mapiritsi 28 ndi pafupifupi ma ruble 200, kuyika kwa mapiritsi 28 a Liptonorm 20 mg kuli pafupifupi 390 rubles.

Maphunziro: Yoyamba University State Medical University yotchedwa I.M. Sechenov, wapadera "General Medicine".

Zambiri zokhudzana ndi mankhwalawa ndizofanana, zimaperekedwa pazidziwitso ndipo sizilowa m'malo mwa malangizo aboma. Kudzipatsa nokha mankhwala kuopsa!

Chiwindi chanu chikasiya kugwira ntchito, imfa imatha pakatha tsiku limodzi.

Amayi ambiri amatha kusangalala mwakuganizira za thupi lawo lokongola pakalilore kuposa kugonana. Chifukwa chake, akazi, yesetsani kuyanjana.

Pogwira ntchito, ubongo wathu umagwiritsa ntchito mphamvu zambiri zofanana ndi babu la 10-watt. Chifukwa chake chithunzi cha babu wapamwamba pamutu panu panthawi yomwe chikuwoneka ngati chosangalatsa sichili kutali ndi chowonadi.

Malinga ndi kafukufuku, azimayi omwe amamwa magalasi angapo a mowa kapena vinyo pamlungu amakhala pachiwopsezo chotenga khansa ya m'mawere.

Munthu amene amamwa mankhwala opondeleza nthawi zambiri amakhalanso ndi nkhawa. Ngati munthu athana ndi kukhumudwa paokha, ali ndi mwayi wonse wakuyiwalako zamtunduwu mpaka kalekale.

Kutentha kwambiri kwa thupi kudalembedwa ku Willie Jones (USA), yemwe adamulowetsa kuchipatala ndi kutentha kwa 46,5 ° C.

Ngati mumamwetulira kawiri kokha patsiku, mutha kuchepetsa kuthamanga kwa magazi ndikuchepetsa chiopsezo cha matenda a mtima ndi stroko.

Pochezera pafupipafupi pakama pofufuta, mwayi wokhala ndi khansa yapakhungu umawonjezeka ndi 60%.

Anthu omwe amakonda kudya chakudya cham'mawa nthawi zambiri amakhala onenepa kwambiri.

Mimba ya munthu imagwira ntchito yabwino ndi zinthu zakunja komanso popanda chithandizo chamankhwala. Madzi am'mimba amadziwika kuti amasungunula ngakhale ndalama.

Chiwindi ndi chiwalo cholemera kwambiri m'thupi lathu. Kulemera kwake pafupifupi 1.5 kg.

Kulemera kwaubongo wamunthu kuli pafupifupi 2% ya kulemera konse kwathupi, koma kumadya pafupifupi 20% ya mpweya womwe umalowa m'magazi. Izi zimapangitsa kuti ubongo wamunthu ukhale wovuta kwambiri kuwonongeka chifukwa cha kusowa kwa mpweya.

Vibrator woyamba adapangidwa m'zaka za zana la 19. Adagwira ntchito pa injini yankhonya ndipo adapangira kuti azitsatira khungu la akazi.

Nthawi yayitali yotsala ndiyotsika ndi yoyipa.

Mankhwala ambiri poyamba anali ogulitsidwa ngati mankhwala osokoneza bongo. Mwachitsanzo, a heroin adagulitsidwa ngati mankhwala a chifuwa. Ndipo cocaine adalimbikitsidwa ndi madokotala ngati opaleshoni komanso ngati njira yowonjezerera kupirira.

Aliyense angathe kukumana ndi vuto lomwe limataya dzino. Izi zitha kukhala njira yomwe madokotala a mano amagwiritsa, kapena zotsatira za kuvulala. M'modzi ndi.

Ndemanga za odwala za liponorm

Ndi hyperlipidemia wosakanikirana, adotolo adandipatsa mankhwala "Liptonorm." Anatinso pali ndemanga zabwino pa mankhwala a Liptonorm kuchokera kwa madokotala ndi odwala. Sindikudziwa, ngati zingathandize. Ndimatenga "Liptonorm" malingana ndi malangizo, piritsi limodzi patsiku. Mpaka mlingo utakula, izi ziyenera kukhala zokwanira.

Nthawi zambiri ndinali kuvutika ndi kuthamanga kwa magazi komanso kupweteka mumtima mwanga. Ndinatembenukira kwa wamisala, iye ndi banja lathu, ndipo amayi anga adathandizidwa ndi adotolo. Adotolo adalimbikitsa kupita kukayezetsa ndikudutsa mayeso onse. Zinapezeka kuti m'magazi anga kuchuluka kwa cholesterol kunachuluka ndipo ndikufunika kuti ndichepetse. Inali panthawiyi pomwe dokotala amandiuza kuti ndikhale ndi Liptonorm. Ndinkadya kamodzi patsiku pa 10 mg. Kutenga "Liptonorm" muyenera kutsatira zakudya. Osamadya mafuta komanso okazinga, siyani batala ndi tchizi chamafuta. Pakupita milungu iwiri, cholesterol idayamba kuchepa pang'onopang'ono, ndipo patatha milungu ina itatu idabwinanso. Tsopano ndikumva bwino, koma ndimatsatira kadyedwe kanga.

Abambo anga nthawi ina amapatsidwa liptonorm yolimbana ndi cholesterol yayikulu. Malinga ndi zomwe ndawona, ndikuzindikira kuti katatu patsiku zimutenga, chifukwa chonsecho sakhala kalikonse popanda chakudya chapadera. Ndikwabwino kupatsanso mowawo mkaka pakumwa kumwa kwa liponorm, ndiye kuti, ngakhale patchuthi, musadzilolere kutsitsa mowa (ndikuwonjezera mphamvu, kukana kosatha), apo ayi pamakhala mavuto ndi mtima, impso, kapamba. Pazonse, sindinganene kuti mankhwalawa ndi othandiza kwambiri: aliyense amene ali ndi cholesterol amalowa, ndibwino kuti musamwe mapiritsi, koma jakisoni ndi mphamvu.

Kufotokozera kwapfupi

Liptonorm (chinthu chogwira ntchito ndi atorvastatin) ndi mankhwala ochepetsa mphamvu ya lipid omwe ali m'gulu la HMG-CoA reductase inhibitors (mwanjira ina, kwa ma statins). Kuponderezedwa kwa ntchito ya enzyme yomwe tatchulayi kumabweretsa zotsatira zingapo zotsatizana, zotsatira zake zomwe kuchepa kwa kuchuluka kwa cholesterol mkati mwa maselo ndikuyambitsa ma LDL receptors, zomwe zimayambitsa kuthamangitsidwa kwa kuwonongeka kwa cholesterol "yoyipa" (LDL). Mphamvu ya hypolipidemic ya liptonorm imayamba chifukwa cha kuchepa kwa cholesterol yathunthu, koma makamaka chifukwa cha LDL osati kuwononga cholesterol "yabwino" (HDL). "Kusaloledwa" kwa LDL kumadalira mlingo, ndiye kuti, kumakhala kochuluka, kuchuluka kwa liponorm (mwachilengedwe, mkati mwa achire). Dziwani kuti 70% ya kutsitsa-lipid kumatsitsa kumachitika ndi metabolites yogwira mankhwala. Zotsatira za ma statins pamiyala ya triglyceride sizosankha, chifukwa Mankhwalawa sasintha ntchito ya lipoprotein ndi hepatic lipases, osagwira nawo gawo mwachidziwikire mu lipogenis ndi catabolism yamafuta acids aulere. Komabe, kutsika kwa LDL motsogozedwa ndi mankhwalawo, mwanjira ina kapena ina, kumakhudza triglycerides. Liptonorm ndiwofunika osati chifukwa cha zotsatira zake za hypolipidemic: monga ma statins ena, imakhala ndi phindu pa endothelium, kuletsa kukhazikika kwa vuto la endothelial (kutsogolo kwa atherosclerosis), pazitseko zamitsempha yamagazi, imapangitsa bwino magazi, komanso imakhala ndi antioxidant komanso antiproliferative. Mankhwala amatengedwa mwachangu kuchokera m'mimba. Ili ndi bioavailability wotsika kwambiri, chifukwa cha kagayidwe kachakudya m'chiwindi. Hafu ya moyo wa lilime ndi pafupifupi maola 14. Mankhwala amachotsedwa m'thupi limodzi ndi ndulu. Liptonorm likupezeka piritsi. Pharmacotherapy imachitika motsutsana ndi chikhalidwe cha "antihypercholesterolemic" zakudya zotere. Mlingo umayikidwa aliyense payekhapayekha ndipo zimatengera koyamba mafuta a cholesterol. Mlingo wa "kuyambira" wa mankhwalawa malinga ndi malingaliro ambiri ndi 10 mg 1 nthawi patsiku.

The achire zotsatira kuwonekera sabata lachitatu kuyambira chiyambi cha makonzedwe, ndipo kuchuluka kwa zochita za liptonorm zimawonedwa patatha mwezi umodzi wokhazikika mankhwala "kudya". Ngati vutolo likufuna, mankhwalawa amatha kuwonjezeredwa pang'onopang'ono mpaka tsiku lililonse 80 mg, pomwe gawo pakati yowonjezeka liyenera kukhala osachepera milungu 4. Pamaso pathu ndi nthawi ya chithandizo, ndikofunikira kuwunika zonse zofunikira za chiwindi - zomwe zimatchedwa "Chiyesero cha chiwindi." Kuchulukitsa kwa ma amototransferase sikuti kungosankha koma kungoyang'anira zochitika za ma enzymewo mpaka kubwerera kwathunthu. Ndikusungabe katatu ntchito ya AST kapena ALT, kusintha kwa liponorm kapena kusiya kwathunthu kwa mankhwalawa kumalimbikitsidwa. Maonekedwe a zizindikiro za myopathy nthawi ya mankhwalawa akuwonetsa kufunikira kwake kudziwa ntchito ya creatine phosphokinase. Ngakhale kukhalabe ndi mlingo wokwanira wa enzyme iyi, kuchepa kwa mlingo wa liponorm kapena kutha kwa maphunziro a mankhwalawo kumasonyezedwa. Chiwopsezo cha myopathy pamene mukumwa liptonorm imawonjezeka ndikuphatikiza kwa izi ndi antifungal azoles, niacin, erythromycin, cyclosporine. Kukhalapo kwa mbiri ya wodwalayo kwa uchidakwa kumabweretsa udindo wina kwa adotolo, monga Pankhaniyi, mankhwala a liptonorm ayenera kuchitika mosamala kwambiri.

Pomaliza, chidziwitso chofuna kudziwa chiyenera kuperekedwa chomwe chiyenera kusangalatsa owerenga onse. Asayansi aku Russia adachita kafukufuku wofanizira mphamvu ndi chitetezo cha liptonorm ndi mankhwala oyamba a atorvastatin - lyprimar kuchokera ku kampani yopanga mankhwala Pfizer. Chowonadi ndi chakuti mkangano wamuyaya pakati pa majenito ndi mankhwala oyambira akhala ukuchitika kuyambira nthawi yachikumbutso, zomwe zapangitsa asayansi kuchita zambiri zatsopano m'derali. Pankhaniyi, liptonorm inadziwonetsa kuchokera kumbali yabwino kwambiri, kuwonetsa zochitika za hypocholesterolemic zofanana ndi lypimar ndikungodzipereka pang'onopang'ono pankhani yotetezeka.

Pharmacology

Hypolipidemic wothandizila kuchokera pagulu la statins. Malinga ndi lingaliro la kupikisana kwa mpikisano, molekyulu ya statin imamangiriza gawo ilo la coenzyme A receptor komwe HMG-CoA reductase ikalumikizidwa. Gawo lina la molekyu ya statin imalepheretsa kusintha kwa hydroxymethylglutarate kukhala mevalonate, wapakatikati mwa kapangidwe ka mamolekyulu a cholesterol. Kuletsa kwa ntchito ya HMG-CoA reductase kumabweretsa zotsatizana zotsatizana, zomwe zimapangitsa kutsika kwa zinthu zamafuta a cholesterol komanso kuwonjezereka kwa ntchito ya LDL receptors ndipo, motero, inapititsa katemera wa LDL cholesterol (Xc).

Hypolipidemic zotsatira za ma statins zimalumikizidwa ndi kuchepa kwa cholesterol yathunthu chifukwa cha LDL cholesterol. Kuchepa kwa LDL kumadalira mlingo ndipo sikwachizere, koma kokwanira. Mphamvu yoletsa mphamvu ya atorvastatin motsutsana ndi HMG-CoA reductase pafupifupi 70% yotsimikizika ndi zochitika zama metabolites ake ozungulira.

Ma Statin samakhudza zochitika za lipoprotein ndi hepatic lipases, sizikhudza kwambiri kaphatikizidwe ndi katemera wa mafuta aulere acids, chifukwa chake, zotsatira zawo pamlingo wa TG ndizachiwiri komanso mosazungulira kudzera pazotsatira zawo zazikulu pakuchepetsa LDL-C. Kutsika kwapakati pa TG pamankhwala omwe amapezeka ndi ma statins akuwoneka kuti kumalumikizidwa ndi ma protein a hepatocytes omwe amaphatikizidwa ndi catabolism ya STDs, yomwe ili pafupifupi 30% TG. Poyerekeza ndi ma statin ena (kupatulapo rosuvastatin), atorvastatin imayambitsa kuchepa kwamtundu wa TG.

Kuphatikiza pa kuchepetsa lipid-kuchepetsa, ma statins ali ndi zotsatira zabwino pa endothelial dysfunction (preclinical sign of atherosclerosis oyambirira), pakhoma la mtima, atheroma state, kusintha magazi m'thupi, kukhala ndi antioxidant, antiproliferative katundu.

Atorvastatin amachepetsa cholesterol odwala omwe ali ndi homozygous Famer hypercholesterolemia, omwe nthawi zambiri samayankha pochiza ndi lipid-kuchepetsa mankhwala.

Pharmacokinetics

Atorvastatin amatengedwa mwachangu kuchokera kugaya chakudya. Mtheradi bioavailability wotsika kwambiri - pafupifupi 12%, zomwe zimachitika chifukwa cha kutsekeka kwapang'onopang'ono mu mucosa wam'mimba komanso / kapena chifukwa cha "gawo loyambirira" kudzera pachiwindi, makamaka pamalo ochitapo kanthu.

Atorvastatin imapangidwa ndi gawo la CYP3A4 isoenzyme ndikupanga zinthu zingapo zomwe zoletsa za HMG-CoA reductase.

T_1/2 kuchokera ku plasma kuli pafupifupi maola 14, ngakhale T_1/2 zoletsa za ntchito ya HMG-CoA reductase ndi pafupifupi 20-30 maola, chifukwa cha kutenga nawo mbali kwa metabolites yogwira.

Kuphatikiza kwa mapuloteni a Plasma ndi 98%.

Atorvastatin amapukusidwa mu mawonekedwe a metabolites makamaka ndi bile.

Mimba komanso kuyamwa

Mankhwala contraindicated mu mimba ndi mkaka wa m`mawere (yoyamwitsa).

Kugwiritsa ntchito Liptonorm sikulimbikitsidwa azimayi azaka zaubalaosagwiritsa ntchito njira zodalirika zakulera. Liptonorm iyenera kuletsedwa osachepera mwezi umodzi asanakonzekere kutenga pakati.

Migwirizano ndi machitidwe osungidwa

Liptonorm itha kugwiritsidwa ntchito miyezi 24 kuyambira tsiku lopangidwa, malinga ndi malo osungira. Kuti muchite izi, amayikidwa m'malo osalala, owuma komanso osakhazikika kwa ana kuti aziwayika ndi boma lotentha losaposa 25 ° C.

Mtengo wa chida ichi umadalira mitengo yamapulogalamu ndi ma 238 rubles.

Ngati ndi kotheka, mankhwalawa amaloŵedwa ndi mankhwala ofananawo:

• Lipoford
• Atomu
• Vazator,
• Thorvakard
• Atorvastatin,
• Anvistatom,
• Atocord.

Dokotala amasankha ndalamazo. Pofuna kuti pasakhale zovuta zaumoyo, sizikulimbikitsidwa kuti musinthe moyenera mankhwalawa.

Mikhail, wazaka 35, Stavropol: “Ndidagwiritsa ntchito Liptonorm pamene mayesowo adawonetsa cholesterol yokwera m'magazi. Panalibe zotsatirapo zoyipa, komanso maubwino azithandizo. Adotolo adatenga analog yomwe idakhala yothandiza kwambiri. Ndawononga ndalama pachabe, sindikukulimbikitsani kuti ndizitenga. ”

A Angelina, azaka 47, ku Moscow: “Ndakhala ndikulimbana ndi mitsempha yayitali kwa nthawi yayitali. Mankhwalawa adalembera zochizira matendawa. Tsiku loyamba linali nseru, koma kenako zonse zinapita. Ndinachotsa zisonyezo zosasangalatsa, komanso kulemera m'miyendo yanga. Mtengo wakevomerezeka kwa ine. Panalibe mavuto. Ndimalimbikitsa aliyense chifukwa chithandizochi ndi chothandiza. ”

Varvara, wazaka 33, Krasnoyarsk: “Kukhala ndi pakati kwayamba chifukwa cha kunenepa kwambiri komanso mitsempha ya varicose. Dotolo adandiuza mankhwalawa, koma izi zisanachitike, kwa mwezi umodzi ndidatsata zakudya zomwe katswiri adatenga. Kutopa, kukhumudwa, ndi kupweteka m'miyendo kunatha patatha masabata awiri atatha kumwa koyamba. Zotsatira zoyipa za thupi sizinawonedwe. Chida chake ndichothandiza, ngakhale kuti zotsatira zake zimafunika kudikirira. "

Stanislav, wazaka 53, Yaroslavl: "" Mavuto a mtima wam'mimba adayambitsa kufunikira kwa chithandizo chovuta. Kutalika kwa mankhwalawa kunali pafupifupi mwezi. Pali zovuta zambiri, koma sindinadziwe. Mankhwalawa ndi okwera mtengo, ndipo amatha kuonekera patatha masiku angapo atavomerezedwa. ”

Liptonorm - mankhwala othandiza kuchepetsa lipid

Zhuravlev Nikolay Yuryevich

Liptonorm ndi amodzi mwa mankhwala ochepetsa lipid. Chofunikira chachikulu ndicho gawo la atorvastatin, mphamvu yake yomwe imalepheretsa ntchito ya reductase.

Izi zimadziwika chifukwa cha gawo loyambirira la cholesterol synthesis m'thupi, ndipo Liptonorm imalepheretsa izi, chifukwa chomwe cholesterol m'magazi amatsika.