Amaril, analogi yaku Russia ya mankhwala omwe ali ndi mitengo ndi ndemanga

Phwando glimepiride imakupatsani mwayi wochepetsa kuchuluka kwa shuga m'magazi, polimbikitsa kutulutsa insulin kuchokera ku beta cell kupitakapamba. Izi zimakhudzana ndikusintha mayendedwe a pancreatic beta cell pakukweza kwachilengedwe kwa glucose.

Malamulo apadera insulin zimachitika chifukwa cha kulumikizana ndi njira za ATP zotsekera potaziyamu zomwe zimapezeka pamitsempha ya maselo a beta. Glimepiride mosankha kumangirira kumapuloteni ndikuwongolera zochitika zamayendedwe a potaziyamu a ATP, ndiye kuti, kutseka kwawo kapena kutseguka.

Ngati odwala ali osakwanira kagayidwe kachakudya poyamwa mlingo waukulu glimepiridendiye kuti ndizotheka kuchitira limodzi mankhwala glimepiridendi Metformin. Izi zimabweretsa kusintha kwakukulu pakuwongolera kagayidwe, poyerekeza ndi kugwiritsa ntchito mankhwalawa mosiyana. Munthawi yomweyo chithandizo chololedwa. insulin. Nthawi yomweyo, kuwongolera kwa kagayidwe kachakudya kumadziwika, kofanana ndi kugwiritsa ntchito insulin imodzi yokha, koma pazinthu zotere umagwiritsidwa ntchito mlingo wochepa wa insulin.

Kulandila kangapo glimepiride, mwachitsanzo, 4 mg patsiku, imayambitsa kuchuluka kwa zinthu m'magazi, zomwe zimafika pambuyo maola 2,5

Kumiza kumathandizira kuti kukhale kwathunthu kwa yogwira yogwira ntchitoyo. Kudya zakudya kumatha kusokoneza, kupangitsa liwiro lake pang'ono. Akuwonetsedwa glimepiride kudzera impso ndi matumbo. Popanga mkodzo, mankhwalawa sawonekera osasinthika. Mu thupi, glimepiride imapangidwira m'chiwindi ndi CYP2C9 mu metabolites awiri - mphamvu ya hydroxy ndi zotumphukira za carboxy. Palibe chofunikira chambiri chogwira ntchito mkati mwa thupi.

Contraindication

Pali mndandanda waukulu wotsutsana ndi Amaril:

• mtundu 1 shuga
• kuphwanya kwambiri chiwindi ndi impso,
• matenda ashuga ketoacidosismakomedwe ndi chikomokere
• kuyamwa, kutenga pakati,
• kupezeka kwa matenda obadwa nako monga makolo, galactose tsankho, shuga-galactose malabsorption kapena kuchepa kwa lactase,
• zaka za ana
• kusalolera kapena chidwi ndi mankhwalawo ndi zina zotero.

Chenjezo limafunikira poyambira chithandizo cha odwala, popeza panthawiyi pamakhala chiopsezo cha hypoglycemia. Ngati mwayi wopeza hypoglycemia ulimbikire, ndiye kuti muyenera kusintha kamwedwe kake glimepiride kapena mankhwala othandizira. Kuphatikiza apo, kukhalapo kwa matenda wamba komanso matenda ena, moyo, thanzi ndi zina zambiri kumafunikira chisamaliro chapadera.

Zotsatira zoyipa

Mankhwalawa ndi Amaril, zinthu zambiri zosafunikira zimatha kupezeka, mwanjira ina kapena zina zomwe zimakhudza ntchito ya thupi lonse. Nthawi zambiri, zoyipa zimasonyezedwa ndi hypoglycemia, zomwe zimasonyezedwa: mutunjala nseru, kusanza, kutopa, kugona, kukhumudwa, chisokonezo ndi zizindikiro zina zambiri. Nthawi zina chithunzi choopsa cha hypoglycemia chimafanana ndi stroke. Pambuyo pakutha kwake, zizindikiro zosafunikira zimasonekanso kwathunthu.

Pa gawo loyambirira la chithandizo, mavuto ndi masomphenya, kugaya chakudya, ndi kapangidwe ka magazi zimatha kuchitika. Development ndiyothekanso. thupi lawo siligwirizanazomwe zimatha kulowa m'mavuto. Chifukwa chake, ngati zizindikiro zosafunikira zikuwonekera, muyenera kufunsa dokotala.

Malangizo a Amaryl (Njira ndi Mlingo)

Mapiritsiwo adapangira kuti azigwiritsidwa ntchito mkati, osafuna kutafuna komanso kumwa zakumwa zambiri.

Nthawi zambiri, mlingo umatsimikiziridwa ndi kuchuluka kwa shuga m'magazi. Mankhwala, mankhwala otsika kwambiri ndi omwe amapereka, omwe amathandiza kukwaniritsa kuyenera kwa metabolic

Malangizo ogwiritsira ntchito Amaril amanenanso kuti mankhwalawa amafunikira kutsimikiza kwa shuga m'magazi komanso kuchuluka kwa hemoglobin ya glycosylated.

Kudya kotheka kosayenera kwa mapiritsi, komanso kulumpha mlingo wotsatira, sikulimbikitsidwa kuti mudzazidwenso ndi mlingo wowonjezera. Zinthu zoterezi zimafunika kuvomerezedweratu ndi adokotala.

Kumayambiriro kwa chithandizo, odwala amapatsidwa mlingo wa 1 mg. Ngati ndi kotheka, mlingo umakulitsidwa pang'onopang'ono, ndikuwonetsetsa kuchuluka kwa shuga m'magazi malinga ndi chiwembu: 1 mg - 2 mg - 3 mg - 4 mg - 6 mg - 8 mg. Mlingo wabwinobwino tsiku lililonse mwa odwala omwe ali ndi chiwongolero chabwino matenda ashugandi 1-4 mg yogwira ntchito. Mlingo wa tsiku lililonse wa 6 mg kapena kupitilirapo umabweretsa zotsatira za ochepa ochepa odwala.

Mlingo watsiku ndi tsiku wa mankhwalawa amakhazikitsidwa ndi adokotala, chifukwa ndikofunikira kuganizira zina zosiyanasiyana, mwachitsanzo, nthawi yakudya, kuchuluka kwa zochita zolimbitsa thupi, ndi zina zambiri.

Nthawi zambiri, kudya kamodzi kwa tsiku ndi tsiku kwamankhwala kumayikidwa, musanadye chakudya cham'mawa chokwanira kapena woyamba kudya. Ndikofunika kuti mutatha kumwa mapiritsi musaphonye chakudya.

Amadziwika kuti kukonza kagayidwe kazakudya kamakhudzana ndikukula kwa insulin sensitivity, ndipo panthawi ya chithandizo, kufunika kwa glimepiride ikhoza kukana. Mutha kupewa kukulitsa kwa hypoglycemia mwa kuchepetsa mlingo kapena kusiya kumwa Amaril.

Panthawi ya achire, kusintha kwa mlingo glimepiride chitha kuchitika pamene:

• kuchepetsa thupi
• Khalidwe limasintha
• zikamera za zinthu zina zomwe zimatsogolera ku hypoglycemia kapena hyperglycemia.

Monga lamulo, chithandizo cha Amaril chikuchitika kwa nthawi yayitali.

Bongo

Mu milandu pachimake bongo kapena ntchito kwa nthawi yayitali glimepiride kwambiri hypoglycemia, yomwe ikhoza kuwononga moyo, ingachitike.

Ngati mankhwala osokoneza bongo apezeka, muyenera kufunsa dokotala. Hypoglycemia imatha kuyimitsidwa ndikamamwa chakudya, mwachitsanzo, shuga kapena kachidutswa kakang'ono ka maswiti aliwonse. Mpaka pomwe zizindikiro za hypoglycemia zitathetsedwa kwathunthu, wodwalayo amafunika kuyang'aniridwa mosamala ndi madokotala, chifukwa mawonekedwe osafunikira angayambenso. Mankhwala ena zimatengera zizindikirocho.

Kuchita

Kugwiritsa ntchito kwa glimepiride ndi mankhwala ena kumatha kuyambitsa kukula kwa hypoglycemia, mwachitsanzo, ndiInsulin ndi othandizira ena ACE inhibitors, anabolic steroids ndi maimuna ogonana amuna, chloramphenicol,zotumphukira Coumarin, Cyclophosphamide, Dizopyramide, Fenfluramine, Pheniramidol, Fibrate, Fluoxetine, Guanethidine, Ifosfamide, para-aminosalicylic acid, Phenylbutazone, Sulfenamicin aminitraminamide, Clinamide ndi ena.

Phwando acetazolamide, barbiturates, GKS, diazoxides, okodzetsa, Epinephrine ndi othandizira ena achifundo, Glucagonmankhwala ofewetsa thukuta (ogwiritsa ntchito nthawi yayitali), nicotinic acid (pamiyeso yayitali) estrogen ndi progestogens, phenothiazines, phenytoins, rifampicins,Madzi a chithokomiro amakhala ayodini amachititsa kufooka kwa vuto la hypoglycemic, motero, limawonjezera kuchuluka kwa shuga m'magazi.

H2-histamine receptor blockers amatha kuwonjezera kapena kufooketsa mphamvu ya hypoglycemic ya glimepiride. Clonidine, Reserpine, Coumarin ndi obetcha beta.

Amaryl: analogues, mtengo, mapiritsi, zithunzi za ku Russia, malangizo ogwiritsira ntchito

Amaryl - Mankhwalawa cholinga chake ndicho kuchiritsa matenda ashuga amitundu iwiri. Chofunikira chachikulu cha mankhwalawa ndi glimepiride. Pafupifupi, mlingo wake umachokera ku 1 mpaka 3 mg.

Makina owonetsera Amaril:

1. Imalimbikitsa kutulutsa kwa insulin.
2. Pankhaniyi, mankhwalawa ali ndi zolimbitsa, zomwe zimachepetsa chiopsezo cha hypoglycemia.
3. Kutsitsa tizigawo ta atherogenic m'magazi.
4. Kuchepetsa zovuta za oxidative nkhawa.

Omwe Alipo Amaril Mapulogalamu Okhazikika

Chimodzi mwa zofananira zotsika mtengo kwambiri za Amaril pamapiritsi ndi:

Onani momwe ma fanizo a Amaril amagwira ntchito.

Ili ndi chinthu chofanana ndi Amaryl. Zotsatira zakuchizira zimachitika chifukwa cha kutseguka kwa maselo a pancreatic beta ndi zinthu zopangidwa ndi shuga.

Diameride imatengedwa molingana ndi Mlingo wovomerezeka komanso panthawi yake:

1. Kutalikirana pakati pa phwando sikuyenera kupitilira nthawi yoikika.
2. Zolakwika mukamamwa mankhwalawa sizingalepheretsedwe ndikuzunguliridwa kwakukulu kwa mankhwalawo.
3. Wodwalayo ayenera kudziwitsa dokotala za kugwiritsa ntchito mankhwalawa.
4. Kukula kwa hypoglycemia pambuyo pa kupangika kwa Diamerid mu gawo la 1 mg / tsiku, akuwonetsa kuti zakudya zofunikira ndizofunikira.

Mtengo wa diamerid umachokera ku 206 rubles. pa paketi iliyonse.

Mankhwala ali ndi ake machitidwe:

1. Gawo logwira mu mankhwalawa limayambitsa katulutsidwe ndikuchotsa insulin kuchokera ku kapamba.
2. Kuchulukitsa kupezeka kwa zotumphukira zimakhala ndi zotsatira za insulin.
3. Ali ndi ntchito zina.

Tengani, poyamba kunyamula gawo la mankhwalawo. Nthawi zambiri, amasankhidwa potengera kuwunika kwa shuga m'magazi.

Pali malamulo angapo ogwiritsira ntchito mankhwalawa:

1. Kumayambiriro kwa mankhwala, pafupifupi 1 mg ya glimepiride ndi mankhwala, 1 nthawi patsiku.
2. Zotsatira zamankhwala zikaonekera, gawo ili limagwiritsidwa ntchito ngati othandizira.
3. Ngati palibe kusintha, ndiye kuti mutha kuwonjezera mlingo wake mpaka 4 mg / tsiku.
4. Mlingo wapamwamba kwambiri ndi 8 mg / tsiku.

Pafupifupi, mtengo wa mankhwalawa umachokera ku ruble 740-780 pa paketi iliyonse.

Amasintha kuchuluka kwa shuga wamagazi mwa odwala omwe ali ndi matenda a shuga.

Ili ndi zovuta zingapo:

1. Hypoglycemic.
2. Kutulutsa.
3. Zopinga.
4. Kuteteza ndi kubwezeretsa.
5. Antioxidant.
6. Antibacterial.
7. Cholagogue ndi diuretic zotsatira.

Amatsimikiza ndi dokotala mu mulingo woyenera kukwaniritsa:

1. Mafuta ovomerezeka akumagazi ndi mkodzo.
2. Gwiritsani ntchito zodzitetezera ku matenda amtima.
3. Amasonyezedwa kuti azigwiritsidwa ntchito ndi odwala omwe ali ndi matenda a chiwindi, m'mimba kapena matumbo.

Munthawi ya kumwa mankhwalawa, munthu ayenera kutsatira mosamala Mlingo wosankhidwa ndi moyo wake. Pafupifupi, Vijaysar itha kugulika ma ruble 282.

Amaril yotsitsa shuga: malangizo ogwiritsira ntchito, mtengo, ndemanga ndi analogi

Amaryl ndi mankhwala omwe amathandiza kuchepetsa shuga m'magazi.

Kudya kwake kumayambira pomwe kusowa kwa insulini sikungaperekedwenso chifukwa cha njira zina - zochizira, zakudya, mankhwala wowerengeka, koma palibe chifukwa chokwanira kuperekera insulin.

Kumwa mankhwalawa kumathandiza anthu omwe ali ndi matenda ashuga, omwe atha kusintha kwambiri moyo wawo.

Chifukwa chake, Amaryl, analogues omwe amapangidwa ndi makampani osiyanasiyana azamankhwala, amagwiritsidwa ntchito kwambiri pothandizira pakukonzekera kwa insulin m'thupi.

Zizindikiro ndi ntchito yogwira

Amaryl ndi mawonekedwe ake amasonyezedwa matenda amtundu wa II.Chofunikira chachikulu cha mankhwalawa ndi glimepiride.

Mankhwala a m'badwo wachitatu, omwe adapangidwa pamaziko a sulfanylurea, amayamba kugwira ntchito kapamba, pang'onopang'ono kukweza maselo ake a b, omwe ali ndi udindo wopanga insulin. Mothandizidwa ndi kapamba, kapamba amapanga insulini yambiri, ndipo kuchuluka kwa shuga m'magazi kumatsika.

Mapiritsi a Amaryl 2 mg

Kuphatikiza apo, chinthu chogwiritsa ntchito mankhwalawa chimathandizanso paziphuphu zamthupi, kuchepetsa kukana kwawo kwa insulin. Izi ndichifukwa choti glimepiride, ikalowa mu khungu kudzera mu nembanemba, imatha kuletsa njira za potaziyamu. Zotsatira za izi, makatani a calcium a cell otseguka, calcium imalowa mu cellular cell ndikuthandizira kupanga insulin.

Zotsatira zamachitidwe awiriwa, kuchuluka kwa shuga m'magazi kumakhala pang'ono komanso pang'ono koma kwa nthawi yayitali kumachepetsedwa. Amaril ndi ma analogs amasiyana mibadwo yam'mbuyomu chifukwa cha zoyipa zochepa, zotsutsana ndi zovuta za hypoglycemia chifukwa chakudya.

Makhalidwe a mankhwalawa amakupatsani mitundu yambiri yomwe mankhwalawa amagwiritsidwa ntchito pochizira, zindikirani wodwalayo poyambira komanso kumbuyo kwa Amaril, ndikugawa moyenera mankhwalawa tsiku lililonse la mankhwalawa.

Mlingo wa Mlingo ndi Kusankhidwa Kwa Mlingo

Mankhwalawa, monga mtundu uliwonse wa Amaril, amafunikira kukonza ndikusankha kuyeserera kwa mankhwala omwe amafunikira.

Palibe zikhalidwe pano - wodwala aliyense amawona chimodzimodzi. Chifukwa chake, kusankha kwa mankhwalawa kumapangidwa pokhapokha pang'onopang'ono popanga shuga wamagazi pambuyo pa mtundu wina wa mankhwalawo.

M'masiku oyamba ovomerezeka, wodwalayo amapatsidwa mlingo woyambira, womwe ndi 1 mg wa Amaril patsiku. Ngati ndi kotheka, mlingo umakulitsidwa pang'onopang'ono, kuwunikira kuchuluka kwa shuga. Kuchulukaku kumachitika milligram imodzi pa sabata, nthawi zambiri - m'masabata awiri.

Nthawi zambiri, muyeso waukulu womwe umaperekedwa kwa wodwala ndi magalamu asanu ndi limodzi a mankhwalawo. Pokhapokha povomerezeka ndizovomerezeka kuchuluka kwa tsiku ndi tsiku mpaka 8 mg, koma ndikofunikira kumwa mankhwalawa moyang'aniridwa ndi katswiri.

Amaryl imapezeka mu mapiritsi okhala ndi magawo awiri mpaka asanu ndi limodzi a yogwira ntchito. Mlingo wa mapiritsi akuwonetsedwa pa phukusi. Ndikofunika kumwa mankhwalawa pakamwa, osatafuna, ndimadzi ambiri. Amayeserera kumwa mankhwalawa kamodzi patsiku, koma nthawi zina, piritsi la Amaril likhoza kugawidwa pawiri.

Zotsika mtengo zotsutsa ndi ma fanizo

Mtengo wa mankhwalawa ndiwokwera kwambiri - kuchokera ku 300 mpaka 800 ma ruble. Popeza kuti kayendetsedwe kake kakuchitika, nthawi zambiri kwazaka zambiri, m'malo mwa Amaril ndizofunikira.

Mankhwalawa amachokera pazinthu zomwe zimagwiranso ntchito, koma mwakuwononga dzikolo ndipo kampani yopanga ikhoza kukhala yotsika mtengo kwambiri kuposa yoyambayo. Mankhwala otere amapangidwa m'mafakitale opanga mankhwala ku Poland, Slovenia, India, Hungary, Turkey, Ukraine. Amaril m'malo mwa ma analogues aku Russia amapangidwa kwambiri.

Mapiritsi a Glimepiride - analogue wotsika mtengo kwambiri Amaril

Amasiyana mu dzina, ma CD, Mlingo ndi mtengo wake. Chosakaniza chophatikizira mwa iwo ndi chimodzimodzi. Pankhani imeneyi, pamayankho ake, mafunso otsatirawa salondola: "Kodi Amaryl kapena Glimepiride ndi chiyani?" Kapena "Amaryl ndi Glimepiride - pali kusiyana kotani?"

Chowonadi ndi chakuti awa ndi mayina awiri amalonda a mankhwala ofanana ndendende. Chifukwa chake, sikulakwa kuyankhula za ukulu wina wa mankhwala - zimafanana pakapangidwe komanso momwe thupi limagwirira ntchito. Glimepiride yopanga Russian ndi chiwonetsero chotsika mtengo kwambiri cha mankhwalawo.

Amapangidwa monga mapiritsi, ndi mulingo wa 1, 2, 3 ndi 4 mamililita.

Mtengo wa mankhwalawa ndiwotsika kangapo poyerekeza ndi Amaril yemweyo, ndipo chinthu chomwe chikugwirika ndi chimodzimodzi.

Ngati simungathe kupeza, mutha kugula Diamerid. Mapiritsiwa amasiyana mayina ndi wopanga okha. Analogue iyi ya Amaril imapangidwanso m'mapiritsi kuyambira 1 mpaka 4 mg, koma imasiyana ndi Glimepiride pamtengo wokwera pang'ono.

Opanga ku Ukraine mankhwala amapereka mankhwala Glimax, omwe ali ndi mawonekedwe ofanana. Amasiyana muyezo - piritsi ili ndi mamiligiramu awiri kapena anayi a yogwira, mapiritsi 1 mg sapezekapezeka.

Mapiritsi Diamerid 2 mg

Komanso, mitundu yotsika mtengo ya Amaril imapangidwa ndi makampani opanga mankhwala ku India. Mayina awo amalonda ndi Glimed kapena Glimepiride Aykor. Mapiritsi amodzi kapena anayi a milligram alipo. Muthanso kupezeka pamsika wogulitsa mankhwala aku India Glinova.

Kusiyana kwake kuli pokhapokha ngati kampani yopanga, yomwe ili ku India, ndi kampani yothandizira ya Briteni wopanga mankhwala ku Britain. Palinso mapiritsi a ku Argentina otchedwa Glemaz, koma ndiwokayikitsa kuti atchukanso makamaka m'mafakitare m'dziko lathu.

Mndandanda wa kupanga ku Israel, Jordan ndi EU

Ngati pazifukwa zina ogulira sakhulupirira opanga aku India kapena aku India, mutha kugula mitengo yotsika mtengo ya Amaryl, yomwe mtengo wake umakhala wokwera kuposa wa mankhwala apakhomo, koma wotsika kuposa wa mankhwala oyambirirawo.

Mankhwalawa amapangidwa ndi makampani ku Czech Republic, Hungary, Jordan ndi Israel. Odwala atha kukhala otsimikiza kwathunthu ndi mankhwalawa - njira yoyendetsera zamankhwala m'maiko awa imasiyanitsidwa ndi machitidwe ake okhwima.

Amix, yopangidwa ndi Zentiva, imaperekedwa kuchokera ku Czech Republic. Mlingo wokhazikika umachokera ku 1 mpaka 4 magalamu, kuluka kwapamwamba kwambiri komanso mtengo wokwanira kusiyanitsa mankhwalawa.

Kampani yotchuka yopanga mankhwala ku Hungary ya Egis, yomwe imayang'ana kwambiri pamisika ya CIS, imatulutsanso Amarila yayo. Chida ichi chimatchedwa Glempid, mulingo woyenera komanso mtengo wokwanira.

Hikma, kampani yayikulu kwambiri yamankhwala ku Jordanian, yomwe idakhazikitsidwa mu 1978, imakhazikitsanso mnzake waku Amaril, wotchedwa Glianov. Simuyenera kudandaula za kuchuluka kwa mankhwalawa - Mankhwala aku Jordani amatumizidwa kumayiko ambiri padziko lapansi, kuphatikiza USA, Canada ndi EU, komwe ulamuliro pazomwe zimagwiritsidwa ntchito kunja ndizovuta kwambiri.

Dzinja ladziko lonse Amaryl (generic) ndi Glimepiride.

Opanga ena

Mitundu yamitundu iyi yotchuka yothandizira kuchuluka kwa shuga m'magazi imapangidwa m'maiko ena padziko lapansi.

Zomera zopangira mankhwala ku Germany, Slovenia, Luxembourg, Poland ndi United Kingdom zimatulutsa mankhwala osiyanasiyana omwe amaloŵa m'malo mwa Amaryl. Komabe, mankhwalawa ndi okwera mtengo kwambiri, motero siabwino kwa odwala omwe ali ndi bajeti yochepa.

Mtengo waukulu kwambiri, wokwera pafupifupi 10 mtengo wa anzawo aku Russia kapena India, ndi ndalama zomwe zimaperekedwa ndi makampani opanga mankhwala ku Switzerland. Komabe, kupeza mankhwala okwera mtengo ngati awa sikumveka bwino - sizigwira ntchito bwino, ndipo kuzitenga kumayambitsa zotsatira zoyipa chimodzimodzi ndi zotengera zotsika mtengo.

Makanema okhudzana nawo

Ndikofunikira kudziwa! Mavuto omwe ali ndi shuga m'magazi nthawi yayitali amatha kubweretsa matenda ambiri, monga mavuto amaso, khungu ndi tsitsi, zilonda zam'mimba, zilonda zam'mimba, komanso zotupa za khansa! Anthu amaphunzitsa zomwe zinawawa kuti azisinthasintha misempha yawo ...

Zambiri zothandiza pa Amaril mu kanemayo:

Palinso mankhwala osiyanasiyana ochokera kwa opanga osiyanasiyana ndi magulu osiyanasiyana amitengo omwe amalowa m'malo Amaryl. Dziwani kuti posankha mankhwala, simuyenera kudalira mtengo wake wamtengo wapatali - sizitanthauza kuti nthawi zonse mtundu woyenera, nthawi zambiri mankhwala otsika mtengo sagwira ntchito poyerekeza ndi mnzake wotsika mtengo.

Mapiritsi a Amaryl - malangizo, ndemanga za wolandirayo, mtengo wake

Amaryl ili ndi glimepiride, yomwe ndi ya m'badwo watsopano, wachitatu, wa sulfonylurea derivatives (PSM). Mankhwalawa ndiokwera mtengo kwambiri kuposa glibenclamide (Maninil) ndi glyclazide (Diabeteson), koma kusiyana kwa mtengo kumatsimikiziridwa ndi kukwera kwambiri, kuchitapo kanthu mwachangu, kuthana ndi kufinya, komanso chiopsezo chochepa cha hypoglycemia.

Ndi Amaril, maselo a beta amatsitsidwa pang'onopang'ono kuposa mibadwo yam'mbuyomu ya sulfonylureas, kotero kupititsa patsogolo kwa shuga kumachepetsedwa ndipo chithandizo cha insulin chidzafunika pambuyo pake.

Ndemanga zomwe zimamwa mankhwalawa ndizabwino: Imatsika shuga bwino, ndi yosavuta kugwiritsa ntchito, imwani mapiritsi kamodzi patsiku, mosasamala za mlingo. Kuphatikiza pa glimepiride koyera, kuphatikiza kwake ndi metformin kumapangidwa - Amaril M.

Malangizo achidule

1. Imayendetsa kaphatikizidwe ka insulin, ndikubwezeretsa gawo loyambirira, mwachangu kwambiri lamasamba ake. PSM yotsalayi idalumpha gawo ili ndikugwirira ntchito yachiwiri, kotero shuga imachepetsedwa pang'onopang'ono.
2. Imachepetsa kukana insulini mwachangu kuposa ena a PSM.

Kuphatikiza apo, mankhwalawa amachepetsa chiwopsezo cha thrombosis, kuchepetsa cholesterol, ndikuchepetsa kupsinjika kwa oxidative.ZizindikiroMatenda a shuga okha mitundu iwiri. Njira yofunikira yogwiritsira ntchito maselo a beta osungidwa pang'ono, omwe ali ndi zotsalira za insulin yawo. Ngati kapamba asiya kutulutsa mahomoni, Amaril sanalembedwe. Malinga ndi malangizo, mankhwalawa amatha kumwa ndi metformin ndi insulin.MlingoAmaryl amapangidwa mu mawonekedwe a mapiritsi okhala mpaka 4 mg ya glimepiride. Kuti mugwiritse ntchito mosavuta, Mlingo uliwonse uli ndi mtundu wake. Amawatenga kwa masiku 10, pambuyo pake amayamba kukula pang'onopang'ono mpaka shuga atasintha. Mlingo wololedwa wambiri ndi 6 mg. Ngati sichikuperekera chiphuphu kwa anthu odwala matenda ashuga, mankhwala ochokera m'magulu ena kapena insulin amawonjezeredwa ku regimen yothandizira.BongoKuchulukitsa mlingo wambiri kumabweretsa hypoglycemia wa nthawi yayitali. Pambuyo matenda a shuga, amatha kubwereza masiku ena atatu. Nthawi yonseyi, wodwalayo amayenera kuyang'aniridwa ndi abale, omwe ali ndi mankhwala osokoneza bongo ambiri - kuchipatala.Contraindication

1. Hypersensitivity zimachitika glimepiride ndi zina PSM, othandizira zigawo zikuluzikulu za mankhwalawa.
2. Kuperewera kwa insulini yamkati (mtundu 1 wa matenda ashuga, kapangidwe ka pancreatic).
3. Kulephera kwakukulu kwaimpso. Kuthekera kotenga Amaril ku matenda a impso kumatsimikizika pambuyo pakupenda chiwalo.
4. Glimepiride imapangidwa mu chiwindi, motero, kulephera kwa chiwindi kumaphatikizidwanso m'malangizo monga contraindication.

Amaryl imayimitsidwa kwakanthawi ndikusinthidwa ndi jakisoni wa insulin panthawi yapakati komanso mkaka wa m`mawere, zovuta za matenda ashuga, kuyambira ketoacidosis mpaka kukomoka kwa hyperglycemic. Ndi matenda opatsirana, kuvulala, kuchuluka kwambiri m'maganizo, Amaril sangakhale okwanira kuteteza shuga, chifukwa chake mankhwalawa amathandizidwa ndi insulin, nthawi yayitali. Kuopsa kwa hypoglycemiaMwazi wamagazi umatsika ngati wodwala matenda ashuwalawo adayiwala kudya kapena sanabwezeretse glucose yemwe adagwiritsa ntchito masewera olimbitsa thupi. Kuti matenda achulukane glycemia, muyenera kudya chakudya chambiri, nthawi zambiri chidutswa cha shuga, kapu ya kapu kapena tiyi wotsekemera ndikokwanira. Ngati mlingo wa Amaril wapitilira, hypoglycemia ikhoza kubwereza kangapo panthawi yamankhwala. Pankhaniyi, shuga atayamba kukula, amayesa kuchotsa glimepiride m'mimba: amayamba kusanza, kumwa adsorbents kapena mankhwala otupa. Mankhwala osokoneza bongo oopsa amapha; chithandizo cha hypoglycemia chimaphatikizira glucose yoyenera. Zotsatira zoyipaKuphatikiza pa hypoglycemia, mukamatenga Amaril, mavuto ammimbayo amatha kuyang'aniridwa (osakwana 1% ya odwala), chifuwa, kuyambira kutupira komanso kuyabwa mpaka kugundana kwa anaphylactic (>Ngakhale kuphatikiza chitetezo, mankhwalawa amakhudza mwachindunji kapamba, zomwe zikutanthauza kuti amafupikitsa kapangidwe ka insulin yanu. PSM imayikidwa pokhapokha ngati metformin singathe kulekerera bwino kapena mlingo wake wokwanira suyenerera kwa glycemia wabwinobwino. Monga lamulo, izi mwina zimatha kubwezera kwambiri matenda a shuga, kapena matenda okhalitsa.

Amaril ndi Yanumet

Yanumet, monga Amaryl, imakhudza magulu onse a insulin komanso kukana insulini. Mankhwala osokoneza bongo amasiyana mu kagwiritsidwe kake ndi kapangidwe ka mankhwala, motero amatha kutengedwa limodzi. Yanumet ndi mankhwala atsopano, chifukwa chake amawononga ma ruble 1800. ya paketi yaying'ono kwambiri. Ku Russia, mayendedwe ake adalembetsedwa: Combogliz ndi Velmetia, omwe ndi otsika mtengo kuposa oyambira .. Nthawi zambiri, chiphuphu cha shuga chimatheka chifukwa chophatikizidwa ndi metformin yotsika mtengo, zakudya, maphunziro olimbitsa thupi, nthawi zina odwala amafunikira PSM. Yanumet ndiyofunika kugula pokhapokha ngati mtengo wake ulibe phindu ku bajeti.

Kusagwirizana ndi odwala matenda ashuga ndi mankhwala okhazikika ndiye chifukwa chachikulu chomwe kuwonongera kwa matenda ashuga. Kusintha kwa njira yochizira matenda ena aliwonse kumadwalitsa nthawi zonse zotsatira zake, chifukwa chake, mwa kusankha kwa odwala, mankhwala osakanikirana ndi omwe amakonda. Amaryl M ali ndi kuphatikiza komwe kumagwiritsidwa ntchito kwambiri pamankhwala ochepetsa shuga: metformin ndi PSM. Piritsi lirilonse limakhala ndi 500 mg ya metformin ndi 2 mg ya glimepiride.Zosatheka kulondola ndendende zonse zomwe zimagwira piritsi limodzi la odwala osiyanasiyana. Pakati gawo la shuga, metformin yambiri, glimepiride yocheperako imafunikira. Palibe oposa 1000 mg a metformin omwe amaloledwa pa nthawi, odwala omwe ali ndi vuto lalikulu ayenera kumwa Amaril M katatu patsiku. Kusankha mlingo weniweni, ndikofunikira kuti odwala omwe alangidwa azitenga Amaril padera pakudya cham'mawa komanso Glucofage katatu patsiku.

Adawunikiridwa ndi Maxim, wazaka 56. Amaril adalembedwa kwa amayi anga m'malo mwa Glibenclamide kuti ndichotse pafupipafupi hypoglycemia. Mapiritsiwa amatsitsa shuga osapweteka kuposa pamenepo, modabwitsa zotsatira zoyipa m'mawu, koma kwenikweni sizinapezeke. Tsopano amatenga 3 mg, shuga amagwira pafupifupi 7-8. Tili ndi mantha kuti tichepetse kwambiri, popeza amayi ali ndi zaka 80, ndipo samamvekanso nthawi zonse chizindikiro cha hypoglycemia.Anayang'aniridwa ndi Elena, wazaka 44. Amaril adalembedwa ndi endocrinologist ndipo adandiwuza kuti ndimwe mankhwala aku Germany, osati otchipa. Kuti ndisunge, ndagula phukusi lalikulu, ndiye kuti mtengo wake piritsi limodzi ndi zochepa. Ndili ndimatumba okwanira miyezi itatu. Mapiritsiwo ndi ochepa kwambiri, obiriwira, amtundu wachilendo. Chotupacho chimakonzedwa, motero ndikofunikira kuchigawa m'magawo. Malangizo ogwiritsira ntchito ndi ochepa - masamba 4 m'zilembo zazing'ono. Kuthamanga shuga tsopano ndi 5.7, mlingo wa 2 mg.Awunikiridwa ndi Catherine, wazaka 51. Ndakhala ndikudwala matenda a shuga kwa zaka 15, munthawi imeneyi ndidasintha mitundu yambiri ya mankhwala. Tsopano ndikumangotenga miyala ya Amaryl ndi Kolya insulin Protafan. Metformin idathetsedwa, adanena kuti ndizopanda pake, kuchokera ku insulin yofulumira ndimamva bwino. Shuga, zoona, siabwino, koma pali zovuta zina.Adafotokozedwa ndi Alexander, wazaka 39. Mapiritsi ochepetsera shuga adandisankhira nthawi yayitali komanso yovuta. Metformin sanayende mwanjira iliyonse, sizotheka kuthana ndi mavuto. Zotsatira zake, tinakhazikika ku Amaril ndi Glukobay. Amasunga shuga bwino, hypoglycemia imatheka pokhapokha ngati simukudya panthawi. Chilichonse ndichabwino kwambiri komanso cholosera, palibe mantha kuti mudzuka m'mawa. Kamodzi, m'malo mwa Amaril, adapatsa Russian Glimepiride Canon. Sindinawone kusiyana kulikonse, kupatula kuti phukusi silabwino.Onetsetsani kuti mwaphunzira! Kodi mukuganiza kuti mapiritsi ndi insulin ndi njira yokhayo yoyeserera shuga kuwongolera? Sichowona! Mutha kutsimikizira izi nokha ndikuyamba kugwiritsa ntchito ... werengani zambiri >>

Amaril: malangizo ogwiritsira ntchito, ndemanga za anthu odwala matenda ashuga, mtengo ndi analogues

Amaril amadziwika kuti ndiodziwika bwino pakati pa odwala matenda ashuga. Kulandila kwake kumalola odwala kuwongolera momwe alili, kuchepetsa mwayi wokhala ndi hyperglycemia. Mankhwala okhawo amalembera anthu okhawo omwe ali ndi matenda a shuga a II.

Zomwe zimagwira ku Amaril ndi glimepiride. Zomwe mapiritsiwo amaphatikizidwira ndizothandiza. Mndandanda wawo udzadalira mlingo wa glimepiride. Kuphatikiza kosiyana kwa zinthu zowonjezera pamapiritsi ndi chifukwa cha mtundu wina.

INN (dzina lapadziko lonse): glimepiride (Latin Glimepiride).

Amalil M1, M2 amagulitsanso malo ogulitsa mankhwala. Kuphatikiza pa glimepiride, kapangidwe ka mapiritsiwa kumaphatikiza metformin mu 250 kapena 500 mg, motsatana. Mankhwala osakanikirana awa amatha kupatsidwa ndi endocrinologist wokha.

Zotsatira za pharmacological

Glimepiride imakhala ndi mphamvu pa thupi. Ndi yotengedwa m'badwo wachitatu sulfonylurea.

Amaryl ali ndi mphamvu yayitali. Mapiritsi akagwiritsidwa ntchito, kapamba amayambitsidwa, ndipo ma cell a beta amayambitsa. Zotsatira zake, insulin imayamba kumasulidwa kwa iwo, mahomoni amalowa m'magazi. Izi zimathandizira kuchepetsa kuchuluka kwa shuga mutatha kudya.

Nthawi yomweyo, glimepiride imakhala ndi extrapancreatic. Zimawonjezera kukhudzika kwa minofu, minofu yamafuta ku insulin. Mukamagwiritsa ntchito mankhwala, antioxidant, antiatherogenic, antiplatelet zotsatira zimawonedwa.

Amaril amasiyana ndi ena omwe amapezeka m'magulu ena a sulfonylurea chifukwa chakuti akagwiritsidwa ntchito, zomwe zimapezeka m'matumbo a insulin ndizotsika kuposa mukamagwiritsa ntchito mankhwala ena a hypoglycemic. Chifukwa cha izi, chiopsezo cha hypoglycemia ndichochepa.

Kulimbitsa njira yogwiritsira ntchito glucose mu minofu ndi mafuta minofu kumakhala kotheka chifukwa cha kupezeka kwa mapuloteni apadera a mayendedwe mu ziwalo za cell. Amaryl amalimbikitsa zochitika zawo.

Mankhwalawa sikulepheretsa njira za ATP zotsekera mtima za mtima. Akadali ndi mwayi kuzolowera moyo wa ischemic.

Chithandizo cha Amaryl chimalepheretsa kupanga shuga m'magazi a chiwindi. Kuwonetsa kumeneku kumachitika chifukwa cha kuchuluka kwa fructose-2,6-biophosphate mu hepatocytes. Izi zimayimitsa gluconeogeneis.

Mankhwalawa amathandiza kutsekereza katulutsidwe wa cycloo oxygenase, kuchepetsa kusintha kwa kusintha kwa thromboxane A2 kuchokera ku arachidonic acid. Chifukwa cha izi, kuchuluka kwa kuphatikiza kwa mapulateleti kumachepa. Mothandizidwa ndi Amaril, kuwonongeka kwa ma oxidative reaction, omwe amawonedwa m'matenda osagwirizana ndi insulin, amachepetsa.

Lemberani mankhwala potengera glimepiride kwa odwala omwe ali ndi matenda amtundu II, ngati zolimbitsa thupi, zakudya sizingakuthandizeni kuyendetsa shuga.

Malangizo ogwiritsira ntchito akuwonetsa kuti amaloledwa kuphatikiza Amaril ndi jekeseni wa metformin, insulin.

Dr. Bernstein akuumiriza kuti kusankhidwa kwa ma hypoglycemic othandizira sikuli kolondola, ngakhale pali zambiri zomwe zingagwiritsidwe ntchito. Amatinso kuti mankhwalawa ndi owopsa, amalimbikitsa zovuta za metabolic. Kuthetsa matendawa, simungagwiritse ntchito mankhwala ochokera ku sulfonylurea, koma zakudya zomwe zimaphatikizidwa ndi mtundu wina wa mankhwala.

Malangizo ogwiritsira ntchito

Tengani Amaryl kuvomerezedwa ndi kusankhidwa kwa adokotala. Katswiriyo amasankha mlingo woyamba wa wodwala aliyense payekha.Zimatengera kuchuluka kwa shuga m'magazi, kuchuluka kwa shuga mu mkodzo.

Kumayambiriro kwamankhwala, ndikulimbikitsidwa kumwa mapiritsi okhala ndi 1 mg ya glimepiride. Onjezani mlingo pang'onopang'ono. Mapiritsi a 2 mg amasamutsidwa osati kale kuposa masabata 1-2 atatha chithandizo. Pa magawo oyamba, dokotalayo amawunika momwe wodwalayo alili, kutengera zomwe zimachitika ndi mankhwalawo, amasintha mankhwalawo. Mulingo wovomerezeka tsiku lililonse ndi 6-8 mg ya glimepiride.

Ngati mankhwala othandizira sangatheke ngakhale mutatenga kuchuluka kokwanira kotheka kwa Amaril, ndiye kuti insulin imawonjezedwanso.

Ndikofunikira kumwa mapiritsi musanadye chakudya 1 kamodzi patsiku. Madokotala amalimbikitsa kumwa mankhwalawa musanadye chakudya cham'mawa. Ngati ndi kotheka, amaloledwa kusintha nthawi yolandirira nkhomaliro.

Mapiritsiwo amameza lonse osafuna kutafuna.

Tsiku lotha ntchito

Gwiritsani ntchito mankhwalawa ndikuloledwa kwa miyezi 36 kuyambira tsiku lotulutsidwa.

Woyenerera endocrinologist ayenera kusankha cholowa m'malo cha Amaryl. Amatha kukupatsirani analogi yopangidwa pamaziko a chinthu chomwechi, kapena asankhe mankhwala opangidwa kuchokera ku zinthu zina.

Odwala amatha kupatsidwa mwayi wogwirizira Russian, Diamerid, wotsika mtengo. Mapiritsi 30 a mankhwalawa, opangidwa pamaziko a glimepiride, ndi mlingo wa 1 mg mu mankhwala, odwala amalipira 179 p. Ndi kukakamizidwa kwa ndende yogwira ntchito, mtengo umakwezeka. Kwa diamerid mu gawo la 4 mg, 383 p.

Ngati ndi kotheka, sinthani Amaryl ndi mankhwala a Glimepiride, omwe amapangidwa ndi kampani yaku Russia Vertex. Mapiritsi awa ndiokwera mtengo. Phukusi la ma PC 30. 2 mg iyenera kulipira 191 p.

Mtengo wa Glimepiride Canon, womwe umapangidwa ndi Canonfarm, ndi wotsika kwambiri. Mtengo wa phukusi la mapiritsi 30 a 2 mg amadziwika kuti ndi wotsika mtengo, ndi 154 p.

Ngati glimepiride ndi yolekerera, odwala amapatsidwa ma analogi ena omwe amapangidwa pamaziko a metformin (Avandamet, Glimecomb, Metglib) kapena vildagliptin (Galvus). Amasankhidwa poganizira zomwe zimachitika m'thupi la wodwalayo.

Mowa ndi Amaryl

Sizingatheke kuneneratu pasadakhale momwe zakumwa zakumwa zoledzeretsa zimakhudzira munthu yemwe amamwa mankhwala osokoneza bongo a glimepiride. Mowa umatha kufooketsa kapena kuwonjezera mphamvu ya hypoglycemic ya Amaril. Chifukwa chake, sizingathe kuwonongedwa nthawi yomweyo.

Mankhwala a Hypoglycemic ayenera kumwa kwa nthawi yayitali. Chifukwa cha izi, kuletsa kwakumwa pakumwa zakumwa zoledzeretsa kwa ambiri kumakhala vuto.

Mimba, kuyamwa

Munthawi yamatumbo a mwana, kuyamwitsa wakhanda, zotumphukira za sulfonylurea sizingagwiritsidwe ntchito. M'magazi a mayi woyembekezera, kuchuluka kwa glucose kuyenera kukhala kosadutsa malire. Kupatula apo, hyperglycemia imabweretsa chiwopsezo cha kubadwa mwatsopano, kumawonjezera kufa kwa ana.

Amayi oyembekezera amapititsidwa ku insulin. Ndikotheka kupatula kuthekera kwa poizoni wamavuto osokoneza bongo kwa mwana mu utero ngati mutasiya sulfonylurea pa gawo lokonzekera kutenga pakati.

Pa mkaka wa m`mawere, mankhwala a Amaril amaletsedwa. Zinthu zodutsa zimapita mkaka wa m'mawere, thupi la wakhanda. Mukamayamwitsa, ndikofunikira kuti mayiyu asinthe mankhwala a insulin.

Kwa odwala ambiri, malingaliro a chithandizo cha endocrinologist sikokwanira kuti ayambe kumwa mankhwala atsopano. Madokotala amati mapiritsi amathandizira kapamba kuti apange insulin, pomwe akuwonjezera chidwi cha minofu kwa icho. Izi zimathandizira kuti glucose ayambe kulowa mu thupi.

Koma odwala akufuna kumva lingaliro la mankhwalawo kuchokera kwa odwala matenda ashuga ena. Kufunitsitsa kudziwa kuwunika kwa odwala ena kumachitika chifukwa cha kukwera mtengo kwa mankhwalawa. Kupatula apo, pali mitundu yambiri yamankhwala ogulitsa omwe amapangidwa kuti achepetse shuga, mtengo wake umatsika kwambiri.

Mukamatenga Amaril kwa zaka 1-2, palibe zoyipa zomwe zimawonedwa. Kuchita kumawonetsa kuti ochepa amakumana ndi zovuta akamagwiritsa ntchito mankhwalawa.

Nthawi zambiri, mavuto amayamba Amaril M akagwiritsidwa ntchito ngati mankhwala, omwe kuwonjezera pa glimepiride amaphatikizanso metformin. Odwala amadandaula chifukwa cha kuzizira thupi, kuyabwa pakhungu, kukula kwa matenda oopsa.

Atatha kumwa mapiritsiwa, anthu ena amamva vuto la hypoglycemic likuyandikira, ngakhale mukamayang'ana zimapezeka kuti kuchepa kwa kuchuluka kwa glucose sikofunikira.

M'miyezi yoyambirira yogwiritsa ntchito, glimepiride amakonzekera bwino shuga. Koma madokotala ena amawona kuti mphamvu ya mankhwalawo imayamba kuwonongeka pakapita nthawi.

Wodwalayo amawonjezera kuchuluka kwa mankhwalawa, kenako amaphatikiza mankhwala. Pokhapokha mwa njira imeneyi ndizotheka kukwaniritsa kusintha kwakanthawi kwa boma.

Koma chifukwa chakuchepa kwa mphamvu ya mankhwalawa, wodwalayo amapitilira shuga mthupi. Izi zimabweretsa kuwonongeka kwapang'onopang'ono.

Mothandizidwa ndi Amaril, odwala matenda ashuga atha kusintha pang'ono pang'onopang'ono kufunika koti apange jakisoni wokhazikika wa insulin. Ngakhale kumayambiriro kwa chithandizo, ambiri ali ndi zizindikiro za hypoglycemia. Odwala amadandaula chifukwa cha mseru, manja akunjenjemera, chizungulire, kumangokhala ndi njala. Pang'onopang'ono, vutolo limayenda bwino, mawonekedwe owoneka amachoka.

Mtengo, kuti mugule

Mapiritsi a Amaryl amagulitsidwa pafupifupi mankhwala onse. Mtengo wa phukusi la zidutswa 30 mwachindunji zimatengera mulingo womwe dokotala walimbikitsa.

Mapaketi a mapiritsi 90 akugulitsidwa. Ngati mumagula Amaril phukusi loterolo, mudzapulumutsa pang'ono. Pozaza matenti 90 (2 mg) muyenera kulipira 1728 p.

Glimepiride Canon

Ndi mankhwala a hypoglycemic omwe amamwa pakamwa. Zimakhudza maselo a kapamba ndikutulutsa insulin.

Mankhwalawa ali ndi mitundu ingapo yamvuto:

1. Kutulutsa kwina-pancreatic pa thupi, komwe kumawonjezera kuthekera kwa minofu kukulitsa insulin.
2. Imachepetsa kukonza kwa insulin m'chiwindi.
3. Imalepheretsa kupanga kwa shuga.

Lemberani pakamwa. Mankhwala osakanikirana ndi insulin atha kutumizidwa, chifukwa chosowa mankhwalawa. Komabe, posankha mtundu wa mankhwalawo, muyenera kuwunika mwatsatanetsatane wa zomwe zili m'magazi. Mankhwalawa nthawi zambiri amakhala aatali. Mtengo pafupifupi wa ruble 165.

Kutalika kwa Glformin

Amalemba mtundu wa shuga wachiwiri mwa odwala omwe ali ndi kunenepa kwambiri. Mankhwalawa amagwiritsidwa ntchito onse mu monotherapy komanso kuphatikiza ndi mankhwala ena.

Mutha kumwa mosasamala chakudya. Mlingo ndi pafupipafupi zimatsimikiziridwa kutengera mtundu womwe umagwiritsidwa ntchito. Lemberani mankhwala mpaka katatu / tsiku. Pakadutsa masiku 15 mukuyenera kusintha mlingo.

Zofananira zamankhwala, mtengo

Amaril yatumizanso ku ma analogu, omwe ali ndi mtengo wokwera, koma zowunikira zowonjezereka:

1. Avandaglim. Muli zinthu ziwiri zowonjezera, zomwe ndi rosiglitazone maleate ndi glimepiride. Amasintha kuwongolera kwa glycemic kwa odwala omwe ali ndi matenda a shuga a 2.
2. Avandamet. Mankhwala osakanikirana otengera rosiglitazone maleate ndi metformin hydrochloride. Zimalimbikitsa insulin chiwopsezo.
3. Bagomet Plus. Kuwonetseraku kumadalira kuphatikizika kwokhazikika kwa zinthu ziwiri izi metformin ndi glibenclamide. Oyamba amachepetsa kuchuluka kwa shuga m'magazi, amalepheretsa kuyamwa kwa mafuta amthupi komanso amachepetsa kuchuluka kwa gluconeogenesis. Metformin imakhudza bwino mawonekedwe a lipid m'magazi, amatsitsa cholesterol ndi triglycerides mmenemo. Glibenclamide imachepetsa zomwe zili m'magazi. About mapiritsi otsika mtengo kuti muchepetse cholesterol - mayina, mitengo ndi malingaliro omwe tidalemba apa.
4. Bagomet. Ili ndi zotsatilapo zingapo zabwino:

• amachepetsa mayamwidwe,
• amachepetsa gluconeogenesis,
• kumawonjezera kuphatikizika kwa glucose,
• kumawonjezera kuthekera kwa minofu pazotsatira za insulin.

Mtengo wake umachokera ku ruble 68 mpaka ma ruble 101.

Zisonyezero zogwiritsira ntchito mapiritsi a Amaryl

The yogwira mankhwala malinga ndi malangizo pokonzekera Amaril ndi glimepiride.

Mankhwalawa ali ndi zotsatirapo zabwino:

1. Amathandizira kupanga insulin.
2. Kuchulukitsa chiwopsezo cha zimakhala kuti insulin opangidwa ndi thupi.
3. Amatulutsa insulin.
4. Ali ndi ntchito zina.
5. Kutha kusintha myocardium ku ischemia kumakhalabe.
6. Zochita za antithrombotic.

Mankhwala a matenda a shuga a 2 amagwiritsidwa ntchito. Potere, mankhwalawa angagwiritsidwe ntchito onse mu monotherapy, komanso pamodzi ndi mankhwala ena.

Zotsatira zoyipa Amaryl

Kuchokera pamtima ndi magazi (hematopoiesis, hemostasis):

• kutsitsa magazi
• thrombocytopenia
• Leukopenia
• granulocytopenia,
• agranulocyto,
• erythropenia
• pancytopenia
• hemolytic ndi aplastic anemia.

Kuchokera wamanjenje ndi ziwalo zam'maganizo:

• chizungulire
• mutu
• kuchepa kwakanthawi kowoneka.

Kuchokera m'mimba:

• nseru
• kusanza
• kupweteka m'mimba
• kumva kutopa kwambiri m'chigawo cha epigastric,
• pono
• intrahepatic cholestasis.

Kuchokera kumbali ya kagayidwe:

Zina:

• kuchuluka kwa ma transamine,
• hyponatremia,
• khungu lawo siligwirizana,
• mochedwa
• asthini,
• kupuma movutikira
• hepati
• mziwindi vasculi,
• zithunzi.

Contraindication Amaryl

Hypersensitivity, insulin amadalira matenda a shuga: mtundu wa matenda ashuga ketoacidosis, matenda ashuga komanso chifuwa, kusakwanira kwa chiwindi ndi impso, cachexia, pakati, kuyamwitsa.

Zoletsa kugwiritsa ntchito:

• Zaka za ana (chitetezo ndi kugwiritsa ntchito bwino ntchito kwa ana sizinadziwike).

Mlingo ndi makonzedwe

Mkati, osatafuna, ndimadzi ambiri, musanadye chakudya cham'mawa chambiri.

Mlingo woyambirira (kuphatikiza pamene udachotsedwa pamankhwala ena opatsirana pakamwa) ndi 1 mg kamodzi patsiku, ngati kuli kotheka, mlingo wa tsiku ndi tsiku umakulitsidwa pang'onopang'ono (1 mg sabata iliyonse ya 1-2) mpaka 6 mg.

Mlingo woyambira ndi kukonza umakhazikika paziwunika kawiri magazi ndi mkodzo.

Ndi chindapusa cha shuga mellitus, mphamvu ya insulin imachulukana, yomwe ingafune kusintha kwa mlingo.

Malangizo apadera

Kuchiza kumayamba pokhapokha ngati kudya ndi kuchita masewera olimbitsa thupi sikumapangitsa kuti shuga azikhala ndi magazi.

Kumayambiriro kwa mankhwalawa, posankha mtundu wa mankhwalawa, tikulimbikitsidwa kudziwa kuchuluka kwa glucose othamanga komanso maola anayi aliwonse, mtsogolomo ndikofunikira kuwongolera kuchuluka kwa glucose komanso kuchuluka kwa shuga mumkodzo wa tsiku ndi tsiku, nthawi ndi nthawi (miyezi 3-6 iliyonse) kudziwa glycosylated hemoglobin.

Ngati vutoli silikwanira kapena zotsatira zake zalefuka (kukana kwachiwiri), kuphatikiza ndi insulin ndikulimbikitsidwa.

Poyerekeza ndi maziko a kudya pafupipafupi, hyperglycemia ndiyotheka.

Chiwopsezo chachikulu cha kukhala ndi hypoglycemia chimapezeka mwa odwala ofooka komanso otupa, okhala ndi adrenal, pituitary, kapena chiwindi.

Kuchepa kwa hypoglycemia kumachulukitsidwa ndi mowa, kulumpha chakudya, kusowa kwa zopatsa mphamvu mu chakudya, kuchita masewera olimbitsa thupi mochulukira.

Gwiritsani ntchito mosamala mukamagwira ntchito yoyendetsa magalimoto ndi anthu omwe ntchito yawo imalumikizidwa ndi chidwi chochuluka.

Amaril mankhwala a m'badwo watsopano

Malangizo a Amaril omwe angagwiritsidwe ntchito amapereka chithandizo ngati mankhwala am'badwo watsopano wamankhwala kuthana ndi matenda amtundu wa 2. Chimodzi mwabwino kwambiri lero chinali Glibenclamide-HB-419 kuchokera ku gulu la sulfonylurea. Oposa theka la odwala matenda ashuga omwe ali ndi mtundu wachiwiri adakumana nawo.

Amaril ndi mtundu wosinthika wa Glibenclamide, wopangidwa kuti ukwaniritse zofunikira zatsopano zakuwongolera "matenda okoma."

Pharmacological mawonekedwe a mankhwala

Amaryl ndi mankhwala a hypoglycemic omwe amathandiza kuwongolera dzuwa la plasma. Yogwira pophika mankhwala ndi glimepiride. Monga omwe adatsogolera, Glibenclamide, Amaril ndiwonso wochokera ku gulu la sulfonylurea, lomwe limalimbikitsa kaphatikizidwe ka insulin kuchokera ku maselo a b pancreatic a Langerhans.

Kuti akwaniritse zomwe akufuna, amatseka njira ya potaziyamu ya ATP ndi chidwi chochulukirapo.

Sulfonylurea ikalumikizana ndi ma receptor omwe ali pamalimba a b-cell, zochitika za gawo la K-AT zimasintha.

Kutsekeka kwa njira za calcium ndi kuwonjezeka kwa kuchuluka kwa ATP / ADP mu cytoplasm kumapangitsa kuti membrane awonongeke. Izi zimathandiza kumasula njira za calcium ndikuwonjezera kuchuluka kwa calcium ya cytosolic.

Zotsatira za kukopa kwachidziwikire kwa ma granules achinsinsi, omwe ndi njira yotulutsira maselo a mankhwala ophatikizira mkati mwa sing'anga, amatha kutulutsa insulin m'magazi.

Glimepiride ndi woimira m'badwo wachitatu wa sulfonylureas. Zimapangitsa kuti amasulidwe mahomoni a pancreatic mwachangu, amathandizira chidwi cha insulini cha mapuloteni komanso maselo a lipid.

Tizilomboti timatulutsa michere timagulugasi timagwiritsa ntchito mapuloteni ochokera ku ma cell a cell. Ndi mtundu wodziimira payekha wa shuga, kusintha kwa shuga m'matipi kumachepetsedwa. Glimepiride imalimbikitsa kukwera kwa kuchuluka kwa mapuloteni oyendetsa ndikuwonjezera ntchito yawo. Mphamvu yamphamvu kwambiri ya kapamba imathandizira kuchepetsa kukanira kwa insulin (insensitivity) kwa mahomoni.

Amaryl imalepheretsa kuphatikizika kwa glucogen ndi chiwindi chifukwa cha kuchuluka kwa kuchuluka kwa fructose-2,6-bisphosphate ndi antiaggregant (chopinga cha kupangidwa kwa thrombus), antiatherogenic (kuchepa kwa zizindikiro za cholesterol "choyipa") komanso antioxidant (kusinthika, kuthana ndi kukalamba). Njira za oxidation zimachepetsedwa chifukwa chowonjezeka pazomwe zimakhala za end-native b-tocopherol komanso ntchito ya antioxidant enzymes.

Ngakhale milingo yaying'ono ya Amaril imathandizira kwambiri glucometer.

Pharmacokinetics wa mankhwala

Popanga Amaril, gawo lalikulu lomwe limagwira ndi glimepiride kuchokera ku gulu la sulfonylurea. Povidone, lactose monohydrate, magnesium stearate, microcrystalline cellulose ndi utoto wa E172, E132 amagwiritsidwa ntchito ngati ojambula.

Amaryl imayendetsa michere ya chiwindi 100%, kotero ngakhale kugwiritsidwa ntchito kwa nthawi yayitali kwa mankhwalawa sikuwopseza kudzikundikira kwake pazinthu komanso minyewa. Zotsatira zakonzedwe, zotumphukira ziwiri za glipemiride zimapangidwa: hydroxymetabolite ndi carboxymethabolite. Metabolite yoyamba imapatsidwa mankhwala omwe amapereka chokhazikika cha hypoglycemic.

M'magazi, zomwe zimakhala pazomwe zimagwira ntchito zimawonedwa pakatha maola awiri ndi theka. Kuwona zamtundu wathunthu wa bioavailability, mankhwalawa saletsa odwala matenda ashuga posankha zakudya zomwe "agwiritse" mankhwalawo. Mafuta adzakhala mulimonse 100%.

Likukhalira kuti mankhwala pang'onopang'ono, mlingo wa kumasulidwa kwa zimakhala ndi madzi kuchokera ku mankhwala (chilolezo) ndi 48 ml / min. Kutha kwa theka-moyo kumachokera ku maola 5 mpaka 8.

Kupititsa patsogolo kwakukulu mu glycemic indices kumawonedwa ngakhale ndi zovuta ndi chiwindi, makamaka, mukulira (woposa zaka 65) komanso ndi vuto la chiwindi, kugwiritsidwa ntchito kwa chinthucho ndi kwachibadwa.

Momwe mungagwiritsire ntchito Amaryl

Mankhwala amapangidwa mwanjira ya mapiritsi ozungulira omwe ali ndi mzere wogawa, womwe umakupatsani mwayi wogawa muyezo. Mtundu wa mapiritsiwo umatengera Mlingo: 1 mg glimepiride - chipolopolo, 2 mg - khungu, 3 mg - chikasu.

Kapangidwe kameneka sikanasankhidwe mwamwayi: ngati mapiritsi amatha kusiyanitsidwa ndi mtundu, izi zimachepetsa chiopsezo cha bongo mwangozi, makamaka mwa okalamba.

Mapiritsi amayikidwa m'matumba a 15 ma PC. Bokosi lililonse limatha kukhala ndi mitundu iwiri mpaka itatu.

Njira ya mankhwala ndi mankhwala ndi yayitali, ali ndi malingaliro ambiri. Mwachitsanzo, simungalumphe chakudya chotsatira mukamamwa mankhwalawo.

Zomwe mungagwiritse ntchito pa Amaril:

1. Piritsi (kapena gawo lake) limamezedwa lonse, kutsukidwa ndi madzi osachepera 150 ml. Mukangomwa mankhwala, muyenera kudya.
2. Endocrinologist amasankha dongosolo la mankhwalawa malinga ndi zotsatira za kusanthula kwa zinthu zachilengedwe.
3. Yambani maphunzirowa ndi ma Mlingo wocheperako wa Amaril. Ngati gawo la 1 mg patapita nthawi yochepa silikuwonetsa zotsatira zomwe zakonzedwa, mulingowo umachuluka.
4. Mlingo umasinthidwa pang'onopang'ono, mkati mwa masabata 1-2, kotero kuti thupi likhale ndi nthawi yosinthira kuzatsopano. Tsiku lililonse, mutha kuwonjezera kuchuluka kwa osaposa 1 mg. Mulingo waukulu wa mankhwalawa ndi 6 mg / tsiku. Mulingo wokhazikitsidwa ndi adokotala.
5. Ndikofunikira kukonza zomwe zimachitika ndikusintha kwa kulemera kwa odwala matenda ashuga kapena kuchuluka kwa mitsempha ya minofu, komanso kuwoneka ngati chiwopsezo cha hypoglycemia (ndi njala, kuperewera kwa zakudya m'thupi, kuledzera, mavuto a impso ndi chiwindi.
6. Nthawi yogwiritsira ntchito komanso mlingo wake zimatengera mtundu wamoyo ndi mawonekedwe a kagayidwe. Nthawi zambiri, kamodzi pamakonzedwe a Amaril amakhazikitsidwa patsiku limodzi ndi chakudya. Ngati chakudya cham'mawa chadzaza, mutha kumwa mapiritsi m'mawa, ngati chophiphiritsa - ndibwino kuphatikiza phwando ndi nkhomaliro.
7. Mankhwala osokoneza bongo amawopseza ndi hypoglycemia, pamene glucose m'mimba imatsika mpaka 3.5 mol / L kapena kutsikira. Vutoli limatha kupitilira kwa nthawi yayitali: kuchokera maola 12 mpaka masiku atatu.

Mapiritsi a Amaryl (phukusi la zidutswa 30) amagulitsidwa pamtengo wa:

• 260 rub - 1 mg,
• 500 rub - 2 mg aliyense
• 770 rub. - 3 mg aliyense
• 1020 rub. - 4 mg aliyense.

Mutha kupeza mapiritsi a mapiritsi 60, 90,120.

Mabokosi a Amaril amasungidwa kutentha firiji (mpaka madigiri 30) kwa zosaposa zaka zitatu. Zipangizo zothandizira sayenera kupezeka ndi ana.

Zofananira zina za mankhwala

Anthu odwala matenda ashuga, makamaka "odziwa bwino", monga lamulo, amakhala ndi zovuta zambiri zotsutsana: matenda oopsa, mtima ndi mtima, kusokonezeka kwa metabolic, impso ndi chiwindi. Ndi kitiyi, simuyenera kungomwa mankhwala ochepetsa shuga.

Pofuna kupewa nthenda yamitsempha yamagazi ndi mtima, mankhwala omwe ali ndi aspirin adayikidwa. Amaryl imachotsa phula mapuloteni, koma mulingo wake m'magazi sunasinthe. Zotsatira zonse zovuta za ntchito zovuta zimatha kusintha.

Kupititsa patsogolo ntchito AMARE Kuwonjezera yake insulin, Allopurinu, coumarin ofanana nawo, anabolic mankhwala, guanethidine, chloramphenicol, fluoxetine, fenfluramine, pentoxifylline, Feniramidolu, fibric asidi ofanana nawo, phenylbutazone, miconazole, azapropazone, probenecid, quinolones, oxyphenbutazone, salicylates, tetracycline, sulfinpyrazone, Tritocqualin ndi sulfonamides.

Amaril amachepetsa kuthekera kuwonjezera Epinephrine, glucocorticosteroids Diazoxide, mankhwala othandizira, Glucagon, barbiturates, Acetazolamide, saluretics, thiazide diuretics, nicotinic acid, Phenytoin, Phenothiazine, Rifampicin, Chlorpromazine, ndi progestin.

Amaryl kuphatikiza histamine H2 receptor blockers, reserpine ndi clonidine imapereka zotsatira zosayembekezereka ndi madontho a glucometer mbali iliyonse. Zotsatira zomwezi zimapereka mowa ndi Amaril.

Mankhwalawa sasokoneza ntchito ya ACE inhibitors (Ramipril) ndi anticoagulant agents (Warfarin) mwanjira iliyonse.

Kugwirizana kwa Hypoglycemic

Ngati mankhwala ena aliwonse a hypoglycemic ayenera kulowetsedwa ndi Amaril, muyeso wocheperako (1 mg) umayikidwa, ngakhale pokhapokha wodwala atalandira chithandizo cham'mbuyomu muyezo waukulu. Choyamba, momwe chamoyo cha matenda ashuga chimayang'aniridwa kwa masabata awiri, kenako mlingo umasintha.

Ngati wothandizila odwala matenda ashuga omwe ali ndi theka la moyo adagwiritsidwa ntchito pamaso pa Amaril pofuna kupewa kukula kwa hypoglycemia, payenera kukhala kupuma masiku angapo atachotsedwa.

Ngati wodwalayo adatha kusunga kapamba kuti apange mahomoni ake, ndiye kuti jakisoni wa insulin akhoza 100% kulowa Amaryl. Maphunzirowa amayambanso ndi 1 mg / tsiku.

Ngati njira yachikhalidwe yolipira shuga ya Metformin siyilola kuwongolera kwathunthu matenda a shuga, mungathe kuwonjezera Amaril 1 mg. Ngati zotsatirazo sizikukwaniritsa, pang'onopang'ono zimasinthidwa mpaka 6 mg / tsiku.

Ngati chiwembu cha Amaril + Metformin sichinakwaniritse zoyembekezeredwa, chimasinthidwa ndi Insulin, ndikukhalabe chizolowezi cha Amaril. Jakisoni wa insulin amayambanso ndi mlingo wochepera. Ngati zizindikiro za glucometer sizili zolimbikitsa, onjezani kuchuluka kwa Insulin. Kugwiritsanso ntchito limodzi kwamankhwala kumakhalabe koyenera, chifukwa kumakupatsani mwayi wochepetsa mphamvu ya mahomoni ndi 40% poyerekeza ndi mahomoni oyera.

Kuphatikiza pa Amaril, endocrinologist amakhalanso ndi zosankha: Amaperid, Glemaz, Diapyrid, Diameprid, Glimepiride, Diagliside, Reclid, Amix, Glibamide, Gllepid, Glayri, Panmicron, Glibenclamide, Gligenclad, Glliblik Dimari Glimaril, Glyclazide, Manil, Maninil, Glimed, Glioral, Olior, Glynez, Glirid, Gluktam, Glypomar, Glyurenorm, Diabeteson, Diabresid.

Kwa iwo omwe adapangidwira, ndipo omwe mankhwalawo sanalimbikitsidwe

Mankhwalawa adapangira zochizira matenda a shuga a mtundu wachiwiri. Amagwiritsidwa ntchito limodzi ndi monotherapy komanso mu zovuta kuchipatala motsatana ndi Metformin kapena Insulin.

Gawo logwira ntchito la Amaril limagonjetsa chotchinga cha placenta, ndipo mankhwalawa amapatsanso mkaka wa m'mawere. Pachifukwachi, sioyenera kuti azimayi oyembekezera azikumbukira.

Ngati mkazi akufuna kukhala mayi, ngakhale asanakhale ndi pakati pa mwana, ayenera kusamutsidwira ku insulin popanda Amaril.

Kwa nthawi yakudyetsa, nthawi zoterezi zimasungidwa, ngati pakufunika chithandizo ndi Amaril, kuyamwitsa kuyimitsidwa.

Kugwiritsa ntchito mankhwalawa odwala matenda ashuga komanso vuto lomwe lisanafike pa chikomokere ndilosavomerezeka. M'mavuto akulu a matenda ashuga (monga ketoacidosis), Amaryl sawonjezedwa. Mankhwalawa sioyeneranso kwa odwala matenda ashuga okhala ndi mtundu woyamba wa matenda.

Makhalidwe ambiri, mawonekedwe omasulira ndi kapangidwe kake

Pogulitsa, mankhwalawa amapezeka mu 4 Mlingo, kutengera kuchuluka kwa yogwira:

• mapiritsi a pinki - 1 mg
• kubiriwira - 2 mg
• chikasu chopepuka - 3 mg
• mabulosi - 4 mg

Zomwe zimagwira ndi glimepiride. Kuphatikiza pa mawonekedwe omwe akuwonetsedwa, palinso Amaryl M, yomwe ili ndi metformin.

Amaryl M ikupezeka mu 2 dosages, yoyimiriridwa ndi gawo lotsatira la glimepiride / metformin:

Mosiyana ndi mawonekedwe am'mbuyomu, Amaril M amawonetsedwa oyera ndi mawonekedwe a biconvex.

Kutengera zakudya zoyenera, masewera olimbitsa thupi omwe amathandiza kuti muchepetse kunenepa, chithandizo chamankhwala chotsimikizika chimatsimikiziridwa kwa mtundu wachiwiri wa matenda a shuga ngati:

• lembani matenda osokoneza bongo a shuga omwe samadalira insulini (monga monotherapy kapena mankhwala osakanikirana ndi metformin kapena insulin),
• ngati ndizosatheka kukwaniritsa kuyang'anira kwa glycemic ndi monotherapy yokhala ndi glimepiride kapena metformin,
• Mukamachotsa mankhwala ophatikiza ndi Amaril M.

Amaryl ndi mankhwala ofunikira kwa odwala matenda ashuga a 2 omwe sagwiritse ntchito insulin.

Zotsatira zoyipa ndi bongo

Chimodzi mwazinthu zosayenera kwambiri ndikuchepa kwa shuga m'magazi, zomwe ndi izi:

• kumverera kofooka
• chizungulire
• dzanzi la miyendo
• kuchuluka
• Kumva njala
• tachycardia kapena kugunda mtima kwapang'onopang'ono,
• mavuto ndi ntchito zowoneka.

Tikamalimbana kwambiri ndi hypoglycemia, timatchulidwe timatchulidwe. Nthawi zina Zizindikiro zimafanana ndi kugwidwa, limodzi ndi vuto losazindikira komanso khungu.

Ntchito yayikulu ya gawoli ndikuwonjezera msanga magazi.

Zotsatira zina za Amaril:

1. Machitidwe amanjenje. Wodwalayo amakhala ndi chizungulire, amavutika kugona, kapena kugona kwambiri. Kudzimva kutopa kapena kukwiya mwadzidzidzi ndi nkhawa. Makamaka chidwi chimatayika, zochitika zama psychomotor zimachepetsa. Wodwalayo amadziona ngati wopanda thandizo. Kuda nkhawa, kulephera kudziletsa, kutukwana kwambiri, kukokana, kukhumudwa kungayambitse kupuma.
2. Matumbo. Zotsatira zoyipa za Amaril pamatumbo am'mimba zimawonetsedwa ndi kusanza, kumva kupweteka m'zigawo za epigastric, nseru, kutsegula m'mimba, khungu kusintha kwa chikasu, chiwindi ndi hepatitis.
3. Masomphenya. Zotsatira zoyipa za mapiritsi zimadzipangitsa kumva kumayambiriro kwa chithandizo. Wodwalayo amamva kuchepa kwa masomphenya, omwe amalumikizidwa ndi kusintha kwadzidzidzi m'magazi a magazi.
4. Mtima. Zovuta zamtima zam'kati tachycardia, angina pectoris, bradycardia, ochepa matenda oopsa, kapena kusokonekera kwa mtima.
5. Mwazi. Njira yamagazi ikusintha. Matenda a anemia, leukopenia, thrombocytopenia, erythrocytopenia, granulocytopenia, pancytopenia kapena agranulocytosis.
6. Hypersensitivity a pakhungu. Amawonetsedwa ndi mawonekedwe a urticaria, chotupa cha matupi awo onse. Pankhaniyi, thupi lawo siligwirizana limatha kuyamba kudandaula ndi anaphylactic.

Ngati zizindikiro izi zaledzera kapena zovuta zimachitika, wodwalayo ayenera kuonana ndi dokotala. Thandizo loyamba lodziyimira ndikutenga mwachangu chidutswa cha shuga, maswiti kapena tiyi wokoma.

Kuyanjana Ndi Mankhwala Ndi Analogi

Popereka mankhwala kwa wodwala limodzi ndi mankhwala ena amaryl, kuyanjana kwawo kumawaganiziridwa:

• insulin ndi mapiritsi ena a hypoglycemic kanthu amatsogolera pakuwonjezeka kwa mphamvu ya hypoglycemic ya Amaril,
• adrenaline, sympathomimetics - kuchepa kwa vuto la hypoglycemic,
• reserpine, clonidine, histamine H2-receptor blockers - kuoneka ngati kusakhazikika kwa zotsatira za hypoglycemic,
• Zinthu zokhala ndi ethyl - kutengera kuchuluka kwa ethanol m'magazi, kuwonjezeka kapena kuchepa kwa mphamvu ya hypoglycemic ndikotheka.

Ma analogu omwe akupezeka omwe ali ndi vuto lofananalo, ali ndi gawo lofananalo ndipo amagulitsidwa pamtengo wotsika mtengo:

1. Glimepiride Canon. Analog yotsika mtengo ya Amaril, yomwe imalembedwa chifukwa chosagwira ntchito yothandiza pochita masewera olimbitsa thupi komanso kuchita zolimbitsa thupi.
2. Glimepiride. Mankhwala ofanana ndi Canon omwe ali ndi mankhwala omwewa. Imakhala ndi zotsutsana. Kugwiritsa ntchito nokha koletsedwa. Kupanga kwa Russian Federation.
3. Diamerid. Lembani mapiritsi a shuga a 2. Chimalimbikitsidwa chifukwa chopanda mphamvu kuchokera pakudya ndi masewera olimbitsa thupi. Adaletsa matenda a shuga 1.

Kusankhidwa kwa analogi kuyenera kuperekedwa kwa katswiri. Mankhwala amagwiritsidwa ntchito malinga ndi chiwembu. Kuphwanya kamodzi kokha kungayambitse zotsatira zoyipa za thupi.

Kodi mankhwalawo amagulitsidwa kuti?

Amaryl ndi mankhwala omwe amagulitsidwa pamaneti a mzinda uliwonse. Mtengo wake umachokera ku ma ruble 238. mpaka 2550 rubles, zomwe zimatengera mlingo wa yogwira glimepiride komanso kuchuluka kwa mapiritsi omwe ali phukusi.

Mutha kugula mapiritsi abwino pamtengo wotsika kuposa omwe mumasitolo ogulitsa pa intaneti. Pogula mankhwala, samalani ndi momwe adayambira, popeza pali zambiri zokhudzana ndi zabodza.

Amaril - ndemanga za madokotala, ma analogi, malangizo ogwiritsira ntchito, mtengo wabwino kwambiri pama pharmacies kuti mugule

Amaril ®

Mkati osafuna kutafuna, kutsuka ndi madzi okwanira (pafupifupi makapu 0,5). Ngati ndi kotheka, mapiritsi a Amaril ® amatha kugawidwa limodzi ndi zoopsa m'magawo awiri ofanana.

Monga lamulo, mlingo wa Amaril ® umatsimikiziridwa ndi kutsata kwa shuga m'magazi. Mlingo wotsika kwambiri wokwanira kukwaniritsa zoyenera za metabolic uyenera kugwiritsidwa ntchito.

Pa mankhwala ndi Amaril ®, ndikofunikira kudziwa pafupipafupi kuchuluka kwa shuga m'magazi. Kuphatikiza apo, kuwunika pafupipafupi milingo ya hemoglobin ya glycosylated kumalimbikitsidwa.

Kukhazikika kwa mankhwala osokoneza bongo, mwachitsanzo, kudumpha mlingo wotsatira, sikuyenera kubwezeretsedwanso ndi kudya kwapamwamba.

Zochita za wodwalayo pakafunika zolakwa mukamamwa mankhwalawo (makamaka, polumphira mlingo wotsatira kapena kudumphira chakudya) kapena pamikhalidwe yomwe sizingatheke kumwa mankhwalawa ayenera kukambirana kaye ndi wodwalayo ndi dokotala.

Koyamba mlingo ndi kusankha kwa mankhwala

Mlingo woyambirira ndi 1 mg ya glimepiride 1 nthawi patsiku.

Ngati ndi kotheka, tsiku lililonse mlingo ungakulidwe pang'onopang'ono (pakadutsa masabata 1-2). Ndikulimbikitsidwa kuti kuwonjezeka kwa mlingo kuchitidwa ndikuwonetsetsa kuchuluka kwa shuga m'magazi komanso mogwirizana ndi gawo lotsatira la kuchuluka kwa 1 mg - 2 mg - 3 mg - 4 mg - 6 mg (mg8 mg).

Mlingo umakhala pakati pa odwala omwe ali ndi shuga wambiri

Nthawi zambiri, tsiku lililonse odwala omwe amalamulidwa ndi shuga wambiri amawongolera kuti ndi 4 mg mg glimepiride. Mlingo wa tsiku ndi tsiku wopitilira 6 mg umagwira kwambiri mwa ochepa ochepa odwala.

Nthawi yomwe mumamwa mankhwalawa ndikugawa zamankhwala tsiku lonse limatsimikiziridwa ndi dokotala, kutengera moyo wa wodwalayo panthawi yopatsidwa (nthawi yakudya, kuchuluka kwa zochitika zolimbitsa thupi).

Nthawi zambiri, mlingo umodzi wa mankhwalawa masana ndi wokwanira. Ndikulimbikitsidwa kuti pankhaniyi, mlingo wonse wa mankhwalawo uyenera kumwedwa musanadye chakudya cham'mawa chokwanira, kapena ngati sichinatenge panthawiyo, musanadye chakudya chachikulu choyamba. Ndikofunika kwambiri kuti musadumphe chakudya mutamwa mapiritsi.

Popeza kuyendetsa bwino kagayidwe kachakudya kumalumikizidwa ndi kukhudzika kwa insulin, kufunika kwa glimepiride kumatha kuchepa panthawi ya chithandizo. Pofuna kupewa kukula kwa hypoglycemia, ndikofunikira kuchepetsa mlingo kapena kusiya kumwa Amaril ®.

Momwe mankhwalawa a glimepiride angafunikire:

- Kuchepetsa thupi la wodwala,

- kusintha kwa moyo wa wodwalayo (kusintha kadyedwe, nthawi ya chakudya, kuchuluka kwa zochita zolimbitsa thupi),

- kutuluka kwa zinthu zina zomwe zimatsogolera kukukula kwa hypoglycemia kapena hyperglycemia (onani gawo "Malangizo apadera").

Chithandizo cha glimepiride nthawi zambiri chimachitika kwa nthawi yayitali.

Kusamutsa wodwala kuchokera kwa wothandizira wina wa hypoglycemic wothandizira pakamwa kupita ku Amaryl®

Palibe ubale weniweni pakati pa Mlingo wa Amaril ® ndi ena othandizira a hypoglycemic poperekera pakamwa.

Wothandizanso wina wa hypoglycemic pakakonzedwe kamlomo ndikusinthidwa ndi Amaril ®, ndikofunikira kuti kayendedwe ka kayendetsedwe kake kamafanana ndi koyamba kwa Amaril ®, i.e.

mankhwalawa amayenera kuyamba ndi mlingo wochepa wa 1 mg (ngakhale wodwalayo atamupititsa ku Amaril ® ndi mlingo waukulu wa mankhwala ena a hypoglycemic pakumwa pakamwa). Kuchulukitsa kwa mlingo uliwonse kuyenera kuchitika m'magawo, kukumbukira kuyankha kwa glimepiride molingana ndi malangizo omwe ali pamwambawa.

M'pofunika kuganizira mphamvu ndi kutalika kwa zotsatira za m'mbuyomu hypoglycemic wothandizira pakamwa. Kulowetsa chithandizo kungafunike kuti mupewe zovuta zilizonse zomwe zingapangitse chiopsezo cha hypoglycemia.

Gwiritsani ntchito limodzi ndi metformin

Odwala omwe ali ndi matenda osokoneza bongo omwe amawongolera osakwanira, akalandira mlingo waukulu wa glimepiride kapena metformin, mankhwalawa atha kuphatikizana ndi mankhwalawa.

Pankhaniyi, chithandizo cham'mbuyomu chomwe chili ndi glimepiride kapena metformin chimapitilira mlingo womwewo, ndipo mlingo wowonjezera wa metformin kapena glimepiride umayamba ndi mlingo wochepa, womwe umasinthidwa kutengera mulingo woyenera wa metabolic mpaka muyeso wambiri watsiku ndi tsiku. Kuphatikiza mankhwala kuyenera kuyang'aniridwa ndi achipatala.

Gwiritsani ntchito limodzi ndi insulin

Odwala omwe ali ndi matenda osokoneza bongo omwe amawongolera osakwanira, insulin imatha kuperekedwa nthawi yomweyo mutatenga mlingo waukulu wa tsiku ndi tsiku wa glimepiride.

Pankhaniyi, mlingo womaliza wa glimepiride woperekedwa kwa wodwala amakhalabe wosasinthika. Pankhaniyi, chithandizo cha insulin chimayamba ndi milingo yotsika, yomwe imayamba kuwonjezeka pang'onopang'ono motsogozedwa ndi glucose m'magazi.

Chithandizo chophatikiza chimafunika kuyang'aniridwa mosamala ndi madokotala.

Gwiritsani ntchito odwala omwe ali ndi impso. Pali chidziwitso chochepa pakugwiritsa ntchito mankhwalawa odwala omwe ali ndi vuto la aimpso. Odwala omwe ali ndi vuto la impso amatha kukhudzidwa kwambiri ndi hypoglycemic zotsatira za glimepiride (onani magawo "Pharmacokinetics", "Contraindication").

Gwiritsani ntchito odwala omwe ali ndi vuto la chiwindi. Pali zambiri zochepa pakugwiritsa ntchito mankhwalawa kulephera kwa chiwindi (onani gawo "Contraindication").

Gwiritsani ntchito ana. Zambiri pa kugwiritsa ntchito mankhwalawa kwa ana sikokwanira.

Momwe mungatenge Amaryl: musanadye kapena pambuyo chakudya?

Amaryl amatengedwa chakudya chisanadye, kuti nthawi yakwana iyambike kudya momwe chakudya chadyedwera. Monga lamulo, adokotala amalamula odwala matenda ashuga kuti amwe mankhwalawa musanadye chakudya cham'mawa. Ndipo ngati wodwala nthawi zambiri alibe kadzutsa, imwani piritsi musanadye. Mndandanda womwe uli ndi yogwira glimepiride uyenera kutengedwa chimodzimodzi.

Osayesa kudumpha chakudya mutatha Amaril. Muyenera kudya, apo ayi mankhwalawo amachepetsa shuga m'magazi kwambiri ndipo padzakhala hypoglycemia. Uku ndikovuta kwambiri komwe kumatha kuyambitsa zizindikiro zakusiyanasiyana. Kuchokera ku manjenje ndi palpitations mpaka chikomokere ndi imfa. Kuopsa kwa hypoglycemia ndi chimodzi mwazifukwa zomwe Dr. Bernstein samalimbikitsa kuti atenge glimepiride. Pomwe mungagwiritse ntchito ndi njira yodalirika yoperekera matenda ashuga yachiwiri.

Kodi mankhwalawa amagwirizana ndi mowa?

Malangizo ogwiritsira ntchito mapiritsi a Amaril amafunika anthu odwala matenda ashuga kuti asamamwe mowa panthawi yonse ya mankhwala. Chifukwa kumwa mowa kumawonjezera chiopsezo cha matenda a hypoglycemia ndi chiwindi. Kusagwirizana kwa mankhwala glimepiride ndi mowa ndi vuto lalikulu. Chifukwa ndi mankhwala kwa nthawi yayitali, kudya kwa nthawi yayitali, komanso osati kwa chithandizo chanthawi yochepa.

Nthawi yomweyo, odwala omwe ali ndi matenda a shuga 2 omwe samamwa mapiritsi owopsa ndipo amathandizidwa malinga ndi chiwembuchi saloledwa kumwa mowa momwe angathere. Onani nkhani yakuti “Mowa wa Matenda a shuga” kuti mumve zambiri. Mutha kusunga shuga wabwinobwino ndipo nthawi zina mumalolera kumwa kapu kapena awiri osavulaza thanzi.

Kutenga nthawi yayitali bwanji?

Tsoka ilo, palibe chidziwitso chokwanira chambiri kuti atenga Amaril atayamba kuchitapo kanthu. Shuga wamagazi amatsika kwambiri pambuyo pa maola awiri ndi atatu. Mwambiri, mphamvu ya mankhwalawa imayamba kale kwambiri, pambuyo pa mphindi 30-60. Chifukwa chake musachedwe kudya chakudya kuti hypoglycemia isachitike. Zotsatira zilizonse zotengedwa muyezo wa glimepiride zimatha kuposa tsiku limodzi.

Zomwe zili bwino: Amaryl kapena Diabeteson?

Mankhwalawa onse amaphatikizidwa pamndandanda wazipatala zoyipa za matenda a shuga a 2. Ndi bwino kukana kuzitenga. M'malo mwake, gwiritsani ntchito mankhwala othandizira endocrin-patient.com amalimbikitsa.

Yesetsani kudziwa dokotala yemwe adapereka Amaryl kapena Diabeteson ndi zomwe zili patsamba lino. Mankhwala oyamba, a Diabetes, adachulukitsa kufa kwa odwala omwe adamwa. Chifukwa chake, idachotsedwa mwakachetechete ku malonda. Tsopano mutha kugula kokha mapiritsi a Diabeteson MV. Amachita modekha, komabe ndi zovulaza.

Kodi ndibwino kumwa chiyani: Amaryl kapena Glucophage?

Amaryl ndimankhwala ovulaza. Tsambali endocrin-patient.com ikuyesa kukukakamizani kuti mukane kuzilandira. Glucophage ndi nkhani ina. Awa ndi mankhwala oyambirira a Metformin, gawo lofunikira kwambiri mu njira yothandizira odwala matenda ashuga amtundu wa 2. Metformin si mankhwala owopsa, koma othandiza kwambiri. Kuti mupewe matenda abwino a shuga, muyenera kusintha kaye ngati zakudya zamafuta ochepa. Chakudya chopatsa thanzi chimaphatikizidwa ndi kugwiritsa ntchito mankhwalawa Glucophage, ndipo, ngati ndi kotheka, komanso ndi jakisoni wa insulini yochepa.

Kodi ndingatenge Yanumet ndi Amaril nthawi imodzi?

Amaryl ndi mapiritsi ena okhala ndi glimepiride sayenera kumwedwa pazifukwa zomwe zafotokozedwa pamwambapa. Yanumet ndi mankhwala osakanikirana okhala ndi metformin. Panthawi yolemba, ndimtengo wokwera mtengo kwambiri ndipo mulibe mnzake wotsika mtengo. Mwakutero, mutha kutenga. Koma mutha kuyesa kuchoka pa iyo kukhala metformin yangwiro, yopambana kwambiri ndi mankhwala onse oyambitsidwa ndi Glucofage. Ngati mungathe kuchita izi popanda kuwonjezera vuto la matenda ashuga, mupulumutsa ndalama zambiri mwezi uliwonse.

Amaril analogues

Panthawi yokonzekera nkhaniyo kuchokera ku ma analogu omwe adagulitsidwa, Glimepirid-Teva okha omwe amapangidwa ndi Pliva Hrvatska, Croatia adagulitsa m'masitolo ogulitsa mankhwala. Nthawi yomweyo, Amaril ali ndi malo ambiri achi Russia, omwe ndi otsika mtengo kwambiri kuposa mankhwala oyambirirawo.

Wopanga aliyense amatulutsa mitundu yonse ya mlingo wa glimepiride - 1, 2, 3 ndi 4 mg. Onani kupezeka kwa mankhwala ndi mitengo yamafesi.

Mankhwala oyamba a Amaryl kapena analogues otsika mtengo: zomwe mungasankhe

Werengani apa chifukwa chake Amaryl ndi mawonekedwe ake ndizovulazachifukwa chake muyenera kukana kuzitenga komanso zomwe zili bwino kulowa. Tsambali endocrin-patient.com imaphunzitsira momwe angachepetse shuga m'magazi kuti ikhale yokhazikika popanda kusala, kumwa mankhwala oopsa komanso okwera mtengo, jekeseni waukulu wa insulin.

Amaryl M: mankhwala osakaniza

Amaryl M ndi mankhwala ophatikiza matenda a shuga a 2. Muli zinthu ziwiri zogwira piritsi limodzi - glimepiride ndi metformin. Mukamawerenga pamwambapa, glimepiride ndiyabwino ndipo sibwino kuitenga. Koma metformin siyabwino konse, koma ndiyothandiza kwambiri kwa odwala matenda ashuga. Mankhwalawa amachepetsa shuga m'magazi, amateteza ku zovuta za matenda a shuga, amathandizira kuchepetsa thupi komanso kutalikitsa moyo.

Tsambali endocrin-patient.com imalimbikitsa kuti mutenge metformin yangwiro m'malo mwa Amaril M, mankhwala oyamba kwambiri ndi Glucofage. Alinso ndi anzawo aku Russia, omwe ndi otsika mtengo.

Kodi mapiritsi a Amaryl M ali ndi fanizo lotani?

Amaryl M ndi piritsi lophatikiza lomwe lili ndi zosankha ziwiri: glimepiride ndi metformin. Mankhwala onse, kuphatikizapo glimepiride, ndi oyipa. Amatha kutsitsa shuga m'magazi kwa zaka zingapo, kenako matendawa amasintha kukhala mtundu wovuta kwambiri wa shuga. Mwa odwala matenda ashuga omwe amathandizidwa ndi mapiritsi awa, chiwopsezo cha kufa chifukwa cha kugunda kwa mtima ndi sitiroko sikuchepetsedwa, koma ndikuchulukanso.

M'malo moyang'ana kufanana kwa Amaril M, sinthani kwa metformin yoyera. Zabwino koposa zonse, mankhwala omwe adatumizidwa kunja ndi Glucofage. Zili ndiubwino wabwino, ndipo nthawi yomweyo zimakhala ndi mtengo wotsika mtengo. Komanso gwiritsani ntchito njira yothandizira odwala matenda a shuga a 2. Mudzatha kukhala ndi shuga mokhazikika, monga mwa anthu athanzi, wopanda chakudya "chanjala" komanso kuchita masewera olimbitsa thupi.

Zotsatira za bongo

Kugwiritsa ntchito mankhwalawa kwakanthawi, komanso kumwa mopitirira muyeso, kumayambitsa hypoglycemia, zomwe zimafotokozedwa m'gawo lakale.

Wodwala matenda ashuga ayenera kukhala ndi cholembera chofotokoza bwino za matenda ake ndi china chake kuchokera ku chakudya cham'thupi (maswiti, makeke). Madzi okoma kapena tiyi ndiwofunikanso, pokhapokha popanda zotsekemera zotengera. Woopsa milandu, wodwala ayenera kuchipatala mwachangu kuti akonzenso chapamimba ndi makonzedwe a absorbents (adamulowetsa kaboni, zina ndi zina).

Zotsatira zoyipa

Nthawi zina, kugwiritsa ntchito Amaril kumayendera limodzi ndi zotsatira zoyipa mwanjira ya kutaya kwamaso, mavuto ndi njira yoyendera magazi, matenda a metabolic, matenda am'mimba.

Mwa zina zofala:

1. Glycemic syndrome, yodziwika ndi kusweka, kusokonezeka kwa chidwi, kulephera kuwona, arrhasmia, njala yosalamulirika, thukuta kwambiri.
2. Kusiyana kwazomwe zikuwonetsa shuga, zomwe zimapangitsa kuwonongeka kwa mawonekedwe.
3. Matenda a dyspeptic, kuphwanya mtundu wa defecation, ndikusowa mankhwala akachotsedwa.
4. Thupi lanu losiyanasiyana zovuta (zotupa pakhungu, kuyabwa, ming'oma, matumbo osavomerezeka, anaphylactic kugwedezeka, kuthamanga kwa magazi komanso kufupika kwa mpweya).
   

Kutenga Amaril kumakhudza kuthamanga kwa ma psychomotor reaction - kuyendetsa galimoto, komanso ntchito yofunikira kuti ithe chidwi, makamaka koyambirira kwa chithandizo, sizigwirizana ndi Amaril chithandizo.

Maganizo a madokotala ndi odwala matenda ashuga okhudza Amaril

Ndemanga za a endocrinologists omwe amakumana ndi mawonetseredwe onse amatsenga omwe ali ndi vuto kwambiri, ali ndi mwayi wophunzira momwe odwala amathandizira kuti adziwe momwe amagwirira ntchito.

Malinga ndi madotolo, ndi regimen yoyenera yopanga mankhwala, Amaril amathandizira kupangitsa kuti glycemic indices isafike mokwanira. Anthu odwala matenda ashuga omwe amamwa mankhwalawa amakhala ndi zodandaula za hypoglycemia pamene mulingo wosankhidwa bwino. Ndipo komabe, zamankhwala Amaril, ndemanga za odwala ndi zabwino.

Zakudya zama carb otsika, masewera olimbitsa thupi, kuwongolera kunenepa kwambiri. Wodwala matenda ashuga ayenera kudziwitsa endocrinologist mu nthawi yokhudza mavuto, zizindikiro za hypo- ndi hyperglycemia zomwe zimachitika ndi Amaril.

Chithandizo chimaphatikizanso kudziyang'anira pawokha mayendedwe a shuga ndikuwunika ntchito za chiwindi, mayeso a labotale, makamaka kuyesa kwa hemoglobin ya glycated, yomwe masiku ano imadziwika kuti ndiyo njira yoyesera kwambiri yotsimikizira momwe wodwala alili ndi matenda a shuga. Izi zikuthandizira kuzindikira mulingo wokana Amaril pakukonzanso njira zamankhwala.

Mutha kuphunzira za zina za Amaril kuchokera video.