Kugwiritsa ntchito glyformin mu shuga

Matenda a shuga ndi matenda ofala a endocrine system omwe amakhala ndi matenda osachiritsika. Matendawa amadziwika ndi kuwonjezeka kwa kuchuluka kwa shuga m'magazi chifukwa chosowa insulini (pancreatic hormone). Wodwala amakhala ndi vuto la metabolic, limakhudza mitsempha ya magazi, mitsempha ndi ziwalo zina zofunika. Kuti muwonetsetse chikhululukiro kwanthawi yayitali, muyenera kumwa mankhwala kwa moyo wanu wonse.

Gliformin ndi othandizira a hypoglycemic omwe amaimira biguanides ndipo amagwiritsidwa ntchito pochiza matenda ashuga. Nthawi zambiri imagwiritsidwa ntchito pa matenda a shuga a 2, pomwe minyewa yamtundu wa insulin imachepa. Kenako timadzi timadzi tambiri timene timakhala mthupi ndipo kuledzera kumaonekera. Popewa izi, tengani Glyformin wa matenda ashuga. Mankhwalawa amachepetsa shuga, amawonjezera chidwi cha insulin ndikuwongolera kunenepa kwambiri.

The zikuchokera ndi zomwe mankhwala

Mankhwala amapitilira kugwiritsidwa ntchito ngati mapiritsi amkamwa, omwe amasiyana mu gawo la gawo la yogwira (250, 500, 1000 mg).

Zomwe zimaphatikizidwa ndi mankhwala othandizira odwala matenda ashuga:

• metformin
• wowuma chimanga
• kufinya silika,
• povidone K-90,
• glycerol
• crospovidone
• octadecanoic acid
• hydroxymethylpropyl cellulose-2910,
• polyethylene glycol 6000,
• talcum ufa.

M'mawonekedwe, awa ndi magome oyera okhala ndi chikasu kapena chofiirira cha mawonekedwe owonongera.

Metformin (chinthu chachikulu) imagwira ntchito pokhapokha ngati thupi lipanga insulini kapena mahomoni adalowetsedwa. Ngati mankhwalawo kulibe m'thupi, ndiye kuti metformin siziwonetsa kuchizira.

Pambuyo pakulowetsa, chiwindi chimapanga glucose wocheperako, chifukwa chake, mulingo wake umachepa. Wodwala akayamba kunenepa kwambiri, ndiye kuti amayamba kuchepa komanso thanzi lake limayamba kuyenda bwino.

Metformin imakhala ndi anorexigenic, ndiye kuti, imachepetsa chilimbikitso. Zotsatira zake zimawonekera pambuyo pobayira chigawo chimodzi cha mucosa pamimba. Zotsatira zake, kulakalaka kumachepa ndipo kuchepa kwa shuga kumachepa.

Mankhwala amateteza kulumpha mu glycemia (shuga wamagazi) atatha kudya. Izi zimachitika chifukwa chakuti mayamwidwe am'madzi amachepetsa. Chifukwa cha kudya pafupipafupi, matumbo a m'mimba amagwiritsa ntchito shuga kuchokera mthupi mwachangu.

Chifukwa chake, mphamvu ya antihyperglycemic ya Gliformin imawonetsedwa. Ndiye kuti, mankhwalawa amalepheretsa kuchuluka kwa ndende yamagazi.

Monga tafotokozera mu malangizo, wothandizira wa hypoglycemic amawonetsa fibrinolytic. Izi zikutanthauza kuti mothandizidwa ndi zigawozi, ziwalo zamagazi zimasungunuka komanso kuphatikizika kwa mapulateleti kumapetsedwa.

Mulingo woyenera kwambiri wowonjezera umaonekera patatha maola awiri mutamwa mapiritsi. Otsalira a mankhwalawa amamuchotsa mkodzo.

Mankhwala ndi mankhwala otsatirawa:

• Matenda a shuga omwe amadalira insulin (mtundu 2), makamaka kwa odwala onenepa kwambiri, ngati kudya komanso kuchita masewera olimbitsa thupi sizothandiza.
• Mtundu wachiwiri wa shuga wokhawokha kapena monga gawo la chithandizo chokwanira.
• Odwala a zaka zopitilira 10 (payokha kapena osakanikirana ndi insulin).

Mankhwalawa amagwiritsidwa ntchito pazifukwa zachipatala.

Ntchito ndi mlingo

Mu shuga mellitus, mankhwalawa amathandizidwa pakumwa, pakudya kapena pambuyo pake, piritsi limamezedwa ndikusambitsidwa ndi madzi osefedwa.

Mankhwalawa amagwiritsidwa ntchito pochiza nokha kapena ndi mankhwala ena a hypoglycemic. Mlingo woyambira umachokera ku 500 mpaka 850 mg kawiri kapena katatu maola 24. Pa mankhwala, shuga wamagazi amayenera kuwerengedwa pafupipafupi ndipo mlingo umasinthidwa potengera zotsatira zake. Ndikofunikira kuwonjezera pang'onopang'ono mlingo wa mankhwalawo kuti thupi lizitha kulolera motere.

Kuti mukhale ndi achire, imwani mankhwalawa kuyambira 1500 mpaka 2000 mg tsiku lililonse. Pofuna kupewa zinthu zoipa, mlingo wa tsiku ndi tsiku umagawidwa pawiri kapena katatu. Mlingo wapamwamba ndi 3,000 mg katatu.

Ngati wodwalayo adagwiritsanso ntchito mankhwala ena a hypoglycemic, ndiye kuti muyenera kusiya kumwa ndikangomaliza kutenga Glformin pa mlingo womwe tafotokozawu.

Mlingo wa tsiku ndi tsiku wa odwala kuyambira zaka 10 ndikuchokera 500 mpaka 850 mg kamodzi. Pambuyo masiku 10, mlingo umasintha pambuyo poyesa kuchuluka kwa shuga. Mlingo wapamwamba wa mankhwalawa ndi 2000 mg kawiri kapena katatu.

Kwa odwala okalamba, mlingo umatsimikiziridwa payekhapayekha. Izi ndichifukwa choti mwina angathe kuchepa kwa impso.

Lingaliro la kutalika kwa mankhwala limatsimikiziridwa ndi dokotala aliyense payekhapayekha.

Contraindators ndi malire

Monga malangizo ukunenera, mankhwalawa amatsutsana mu milandu yotsatirayi:

• Kusagwirizana ndi metformin kapena chinthu china.
• Ketoacidosis (kusowa kwenikweni kwa insulin), hypoglycemic coma.
• Matenda aimpso.
• Kuthetsa madzi m'thupi, matenda opatsirana, mantha komanso zina zomwe zimayambitsa matenda a impso.
• Matenda omwe amachititsa kuti pakhale mpweya wofa ndi mpweya wa minofu (yogwira mtima kulephera ndi koopsa kapena koopsa, kupweteka kwa minofu yamtima, ndi zina zambiri).
• Kuvuta kovuta kapena zoopsa momwe insulin chithandizo imayikidwa.
• Matenda a chiwindi.
• Kuledzera kosatha.
• Mimba
• Lactacidemia (lactic acid chikomokere).
• Masiku awiri asanafike kapena mkati mwa maola 48 mutatha kugwiritsa ntchito wailesi ya radioisotope kapena wa radiology pogwiritsa ntchito mankhwala osokoneza bongo a iodini.
• Zakudya zamafuta ochepera (mpaka 1000 kcal mu maola 24).
• Odwala mpaka zaka 10.

Moyang'aniridwa ndi dokotala, odwala omwe ali ndi zaka 60, komanso anthu omwe amagwira ntchito zolimbitsa thupi kawirikawiri, amagwiritsa ntchito mankhwalawa. Kuletsa kumeneku kumagwiranso ntchito kwa akazi anyama.

Nthawi zambiri mankhwalawa nthawi zambiri amaloledwa ndi odwala, koma nthawi zina lactacidemia imadziwonetsa, ndiye muyenera kusiya kumwa mapiritsi. Pogwiritsa ntchito nthawi yayitali, mayamwidwe a zancobalamin amachepetsa (B₁₂).

Odwala ena amadandaula ndi mseru, kusanza, kukokana m'matumbo, kuchepa kwa chakudya, kutsegula m'mimba, kutulutsa magazi, ndi kukoma kwazitsulo mkamwa. Zizindikiro zimatha kuchitika m'masiku oyamba a chithandizo, pambuyo pake zimadzimiririka zokha.

Nthawi zina, khungu limasanduka lofiira, totupa, kuyabwa, malungo am'mimba amapezeka. Nthawi zina chiwindi chimasokoneza, hepatitis imadziwonekera yokha, koma mankhwala atatha, zinthu izi zimazimiririka.

Pa chithandizo ndi Glformin, muyenera kuwunika nthawi zonse momwe impso ndi chiwindi zimayendera. Ngati wodwala amatenga mankhwala ndi zotumphukira za sulfanyl carbamide, insulin, salicylates, zimawonjezera mphamvu ya hypoglycemic. Pachifukwa ichi, ndikofunikira kuthana ndi glucose ndende kuti muteteze hypoglycemia munthawi.

Kutsitsa kwa shuga kumawonetsedwa ndi makulidwe ovuta a Glformin ndi mankhwala otsatirawa:

• Glucocorticoids,
• Kulera kwamlomo
• Glucagon
• Adrenaline
• Mankhwala a chithokomiro a chithokomiro,
• Zodzikongoletsera
• Mankhwala, zotumphukira za phenothiazine.

Glformin ikaphatikizidwa ndi mowa, mwayi wowonjezera kuchuluka kwa lactic acid ukuwonjezeka.

Mankhwalawa sanaperekedwe kwa odwala okalamba, komanso odwala omwe akuchita ntchito yayikulu. Izi ndichifukwa chakuti mwayi wa acidosis (kuchuluka kwa acidity ya thupi) umakulanso.

Mankhwala othandizira odwala matenda ashuga angathe kumwa mankhwala asanachitike. Komabe, ngati wodwalayo atenga mankhwala ena ochepetsa shuga, ndiye kuti pamakhala chiopsezo chochepetsera minofu ndi ntchito zamaganizidwe.

Mankhwala osokoneza bongo

Ngati wodwala ali ndi contraindication, ndiye kuti Glformin ikhoza kulowa m'malo mwa mankhwalawa:

Awa ndi maonekedwe a Glformin ofotokoza mtundu wa Glformin wokhala ndi mfundo yofananira. Mankhwala amasiyana mosiyanasiyana, muyezo komanso mtengo. Kusankha pakusankha mankhwala kumachitika ndi adokotala.

Malingaliro odwala

Odwala ambiri omwe amamwa mankhwalawo monga adauya adokotala amakhutira ndi njira yake yothandizira. Koma ena a iwo amadziwa kuti mankhwalawa amayambitsa mavuto.

Elena:
“Kwa nthawi yayitali ndinapezeka kuti ndili ndi matenda ashuga. Ndasankhidwa kale mankhwala ambiri omwe kuchita kwawo sikunandisangalatse. Gliformin posachedwapa adalembedwa ndi endocrinologist. Mapiritsi awa amangondipulumutsa! Ndakhala ndikumwa iwo pafupipafupi kwa miyezi itatu, thanzi langa lakhala bwino. Malinga ndi dotoloyo, kuwerengetsa magazi kuyambiranso kukhala kwabwinobwino, ndipo pambuyo pake tichita mankhwalawa. ”

Alina:
“Mankhwalawa amandithandiza kuchepetsa thupi. M'mbuyomu, sindingathe kukwaniritsa zofanana ndi mankhwala okwera mtengo, kudya komanso kuchita masewera olimbitsa thupi. Pambuyo pa maphunziro achiwiri, kulemera kunatsika kwambiri. Tsopano ndimamwa mapiritsi kachitatu, monga chotulukapo chake, kuchuluka kwa glucose m'mwazi kwachepa, kupuma movutikira kwatha, kuseka thukuta kwambiri, ndipo thanzi lathunthu lakhala likuyenda bwino. Chifukwa chake ndimalimbikitsa matendawa kwa aliyense amene dotolo awalembera. ”

Irina:
“Posachedwa, malingaliro anga okhudza Gliferomin asintha kwambiri. Izi zinachitika nditamwa mankhwalawa chifukwa cha mseru, kusanza, kukokana m'matumbo ndi m'mimba. Panali chofooka champhamvu, kugona. Izi zitatha, ndidapita kwa dotolo yemwe adandilangiza za mankhwala ofanana ndi Combogliz Prolong. Tsopano ndikumva bwino. Ndipo za Gliformin ndinganene kuti sizoyenera aliyense. ”

Kutengera ndi zomwe tafotokozazi, Gliformin ndi mankhwala othandiza omwe amalimbikitsa chidwi cha minyewa kupita ku insulin, amathandizira kuchepetsa thupi komanso amathandizira magwiridwe antchito a kapamba. Pofuna kupewa zoyipa, mankhwalawa amangogwiritsidwa ntchito pazamankhwala. Wodwala ayenera kutsatira mlingo ndi pafupipafupi wa mankhwalawa.

Zambiri

Gliformin ndi othandizira a hypoglycemic omwe cholinga chake chinali kugwiritsidwa ntchito mkati. Chalangizidwa kwa odwala matenda ashuga. Ndi piritsi yoyera kapena yoyera.

Chidachi chimapezeka ku Russia. Dzina lake lachi Latin ndi GLIFORMIN.

Mankhwalawa amagulitsidwa pokhapokha ngati akupereka mankhwala, chifukwa sioyenera kwa odwala matenda ashuga onse - nthawi zina, kugwiritsa ntchito mankhwalawa kumatha kukhala koopsa. Chifukwa chake, nkosavomerezeka kuyambitsa chithandizo chokha ndi chithandizo chake.

Chofunikira chachikulu mu Glformin ndi Metformin. Ndi gawo limodzi la mankhwalawa monga hydrochloride.

Kuphatikiza apo, mankhwalawa ali ndi zigawo zothandiza:

• povidone
• polyethylene glycol,
• sorbitol
• stearic acid
• calcium phosphate dihydrate.

Glyformin imapangidwa m'mapiritsi okhala ndi zinthu zosiyanasiyana zomwe zimagwira. Pali mapiritsi okhala ndi muyeso wa 500 mg, 800 mg ndi 1000 mg (Glformin Prolong). Nthawi zambiri, mankhwalawa amapakidwa m'maselo a contour, omwe ali ndi magawo 10 a mankhwalawa. Phukusili lili ndi maselo 6. Palinso kutulutsidwa m'mabotolo a polypropylene, pomwe mapiritsi 60 a mankhwalawa amayikidwa.

Pharmacology ndi pharmacokinetics

Mankhwala ndi a gulu la Biguanides. Zochita za metformin ndikupewa gluconeogeneis. Amathandiziranso mafutawa ndipo amalimbikitsa kupangidwa kwa mafuta kwamafuta acid.

Ndi kugwiritsidwa ntchito kwake, zolandirira zotumphukira zimakhudzidwa kwambiri ndi insulin, ndipo maselo amthupi amapanga glucose mwachangu, omwe amachepetsa kuchuluka kwake.

Mothandizidwa ndi Metformin, zomwe zili mu insulin sizisintha. Pali zosintha mu pharmacodynamics yamahomoni awa. Gawo logwira ntchito la Glyformin limalimbikitsa kupanga glycogen. Mukamamwa mankhwalawa, matumbo a m'mimba amayamba kuchepa.

Kuyamwa kwa zigawo zogwira ntchito kumachitika kuchokera m'mimba. Zimatenga pafupifupi maola 2,5 kuti mufikire kuchuluka kwa Metformin.

Izi pafupifupi sizimalumikizana ndi mapuloteni a plasma. Kudzikundikira kwake kumachitika mu impso ndi chiwindi, komanso mu tiziwalo timene timayambira. Ma metabolabolites mutatenga Glformin sakhazikitsidwa.

Excretion ya metformin imaperekedwa ndi impso. Kwa theka-moyo, zimatenga pafupifupi maola 4.5. Ngati zili impso mu impso, kukondoweza kumatha kuchitika.

Zizindikiro ndi contraindication

Kugwiritsa ntchito Gliformin popanda kufunika komanso kuwerengera malangizo kungakhale koopsa thanzi komanso ngakhale moyo. Chifukwa chake, odwala sayenera kuigwiritsa ntchito popanda kusankha dokotala.

Ndikofunikira kuganizira zomwe zikuwonetsa ndi contraindication - pokhapokha chithandizo chidzabweretsa zotsatira zoyenera.

Gawani chida ichi motsatira:

• lembani matenda ashuga 2 mellitus (posapezeka zotsatira za mankhwalawa pakudya ndi pakumwa mankhwala ena),
• lembani matenda a shuga 1 mellitus (limodzi ndi mankhwala a insulin),

Mankhwalawa amatha kugwiritsidwa ntchito ndi achikulire ndi ana kuyambira zaka 10. A osiyana makonzedwe a mankhwala ndi ntchito monga mbali yophatikiza mankhwala amachitidwa.

Asanapereke mankhwala, dokotala amayenera kuphunzira anamnesis, chifukwa matenda ena ndi chifukwa chokana chithandizo ndi mankhwalawa.

Izi zikuphatikiza:

• ketoacidosis
• matenda opatsirana
• wodwala matenda ashuga
• zinthu pafupi ndi chikomokere
• kuvulala kwambiri kwa chiwindi,
• matenda ovuta a impso
• kulephera kwa mtima
• kulephera kupuma
• vuto la mtima
• uchidakwa kapena chakumwa choledzeretsa,
• othandizira opaleshoni ndikuvulala kwambiri,
• kudziwa magawo a mankhwala,
• mimba ndi mkaka wa m`mawere

Munthawi zonsezi, tikulimbikitsidwa kusankha mankhwala ena omwe ali ndi vuto lofananalo, koma osayambitsa zoopsa.

Malangizo ogwiritsira ntchito

Mlingo uyenera kusankhidwa ndi dokotala, poganizira zomwe wodwalayo ali nazo. Nthawi zambiri, kumayambiriro kwa mankhwalawa, kugwiritsa ntchito 0.5-1 g patsiku kumalimbikitsidwa.

Pakupita pafupifupi milungu iwiri, mulingo ungathe kuchuluka. Kuchuluka kwa zinthu zogwira ntchito sikuyenera kupitirira 3 g.

Ndi mankhwala othandizira, tikulimbikitsidwa kumwa mankhwalawa 1.5-2 g. Izi zikuyenera kugawidwa m'njira zingapo.

Okalamba, makamaka omwe kuchuluka kwa zochita zolimbitsa thupi kwambiri, sayenera kumwa mankhwala opitilira 1 g patsiku.

Ndondomeko yotenga Glyformin imatengera zisonyezo zambiri, chifukwa chake dokotala amayenera kuwunika kusintha kwa shuga. Ngati ndi kotheka, sinthani mlingo kuti mupeze zotsatira zabwino. Ndi kusintha kwa moyo wa wodwalayo, mlingo wake uyenera kuunikidwanso.

Kumwa mapiritsiwa amayenera kukhala nthawi ya chakudya kapena itatha. Sikoyenera kuwaphwanya kapena kuwataya - amameza athunthu, atsukidwa ndi madzi.

Kutalika kwa maphunzirowa kungakhale kosiyana. Pokhapokha ngati pali zovuta komanso mphamvu zambiri, mankhwalawa amatha kumwa kwa nthawi yayitali. Ngati zizindikiro zoyipa zikapezeka, ndibwino kugwiritsa ntchito zina m'malo mwake kuti zisawononge mkhalidwe wa wodwalayo.

Malangizo apadera

Pali magulu ena a odwala omwe ayenera kusamala popereka mankhwala.

Izi zikuphatikiza:

1. Amayi oyembekezera. Mankhwala owopsa a Metformin ndi owopsa bwanji kwa mayi ndi mwana wosabadwa sakudziwika, chifukwa palibe kafukufuku omwe adachitika m'derali. Koma chinthu ichi chimatha kulowa mu placenta. Chifukwa chake, kugwiritsidwa ntchito kwa Glformin panthawi ya gestation kumaloledwa pokhapokha ngati pali milandu yayikulu.
2. Amayi oyamwitsa. Zomwe zimagwiritsidwa ntchito ndi mankhwalawa zimatha kulowa mkaka. Ngakhale kuti kunalibe zotsatirapo chifukwa cha izi mu makanda, ndikosayenera kugwiritsa ntchito mankhwalawa ndi mkaka wa m`mawere.
3. Ana. Kwa iwo, Glyformin si mankhwala oletsedwa, koma kungoyambira zaka 10. Kuphatikiza apo, ndikofunikira kuwerengetsa mosamala mlingo.
4. Anthu okalamba. Ndi wodwala wopitilira zaka 60, mankhwalawa ndi osayenera, chifukwa pamakhala chiwopsezo cha zovuta.

Ndikofunikira kulabadira izi kuti zisawononge wodwala.

Kumutenga Gliformin kumafuna kutsatira njira zina zopewera matenda ndi zovuta za wodwala:

1. Simungagwiritse ntchito mankhwalawa ngati wodwala ali ndi vuto lalikulu pachiwindi.
2. Ndi kulephera kwa aimpso komanso mavuto ena omwe ali nawo, mankhwalawo amayenera kutayidwa.
3. Ngati opaleshoni yakonzekera, ndikosayenera kumwa mapiritsi awa musanadutse komanso mkati mwa masiku awiri otsatira.
4. Kuchulukitsa kwa matenda osachiritsika a chiyambi chopatsirana kapena kukulitsa kachilomboka ndikulinso chifukwa cholekerera.
5. Ndikofunikira kuyang'anitsitsa thanzi la odwala omwe akuchita masewera olimbitsa thupi panthawi yanthawi yamankhwala.
6. Mukamagwiritsa ntchito mapiritsiwa, ndikofunikira kuti musiye kumwa mowa.

Izi zidzachepetsa chiopsezo cha zovuta.

Glformin yokhudza matenda ashuga: mtengo, ndemanga ndi fanizo

Mankhwala "Gliformin" ali m'gulu la Biguanides. Awa ndi mankhwala a hypoglycemic omwe amachepetsa kuyamwa kwa glucose ndipo nthawi yomweyo amawonjezera chidwi cha minyewa ina kupita ku insulin. Kuchokera pazomwe zili m'nkhaniyi mupezapo zomwe Glyformin amalamula kuti apatsidwe shuga, mtengo wa mankhwalawa ndi kuwunika kwa odwala enieni.

Mankhwala amapitilira kugwiritsidwa ntchito ngati mapiritsi, omwe akhoza kukhala amitundu iwiri:

• Mapiritsi oyera a cylindrical okhala ndi chamfer yoyera (0.5 g yogwira ntchito). Zidutswa 10 zimayikidwa m'matumba am'manja.
• Mapiritsi mu kanema wa kirimu wa kirimu (0,85 kapena 1 g yogwira ntchito). Zidutswa 60 zimayikidwa mu zitini za polypropylene.

Zomwe zimagwiritsidwa ntchito ndi metformin hydrochloride.

Glyformin ya matenda ashuga iyenera kumwedwa kokha pakamwa. Kapangidwe ka mankhwala pamakina a ziwalo zamkati sikumveka bwino.

Zilowa mthupi, chinthu chogwira ntchito chimakhala ndi zotsatirazi:

• Kuponderezedwa kwa mapangidwe a mamolekyulu a shuga m'magazi.
• Kukhazikitsa kwa kuwonongedwa kwa chakudya chamoto.
• Kuchepetsa kuchuluka kwa shuga m'matumbo.

Kugwiritsa ntchito mankhwalawa "Glyformin" odwala matenda ashuga komanso kunenepa kwambiri kumakhudza kuchepa kwa chidwi cha thupi komanso kunenepa kwambiri. Malangizowo akuwonetsa kuti mankhwalawa amalimbikitsa kusinthasintha pang'onopang'ono kwa kuwundana kwa magazi ndikuletsa kupendekera.

Metformin hydrochloride imalowa mwachangu ndi maselo am'mimba. Pazitali zantchito yogwira ntchito imakhazikika pambuyo pa maola awiri kuchokera panthawiyi. Yake bioavailability pafupifupi 50-60%. Mankhwalawa samakumana ndi mapuloteni a plasma, pang'onopang'ono amadziunjikira machitidwe a ziwalo zamkati. Kuchokera mthupi, thupilo limachotsedwako pafupifupi osasinthika.

Mapiritsi ogwiritsira ntchito amalimbikitsa kutenga odwala omwe ali ndi ma pathologies otsatirawa:

• Matenda a shuga a Type II, pamene mankhwala othandizira pakudya ndi sulfonylurea akukonzekera satha.
• Mtundu woyamba wa matenda a shuga a mellitus (kuwonjezera pa mankhwala a insulin).

Mankhwalawa, kuyang'anira impso ndikofunikira, kamodzi miyezi isanu ndi umodzi ndikulimbikitsidwa kuti muwone lactate m'magazi a magazi.

Kodi ndi mtundu wanji womwe Glformin amalembera shuga? Malinga ndi malangizo, mapiritsiwo amayenera kumwedwa nthawi / mukatha kudya, pomwe amawatsuka ndi madzi. Mlingo ndi nthawi yayitali ya maphunzirowo ndi omwe adalembedwa ndi adokotala, poganizira kuchuluka kwa shuga m'magazi.

Pa gawo loyambirira la mankhwalawa (masiku 15 oyambirira), mankhwalawa salinso 1 g patsiku. Kenako imakulitsidwa pang'onopang'ono. Mankhwala okonza nthawi zambiri samapitilira 2 g patsiku. Imagawanidwanso m'magulu angapo.

Kwa odwala okalamba, tsiku lililonse mankhwala osaposa 1 g.

Dokotala atapereka "Gliformin" yokhudza matenda ashuga, kuwunika kwa odwala enieni kumatha kuwunika momwe mankhwalawo amathandizira. Monga mankhwala ena, amathanso kuyambitsa zovuta zingapo:

• Dongosolo la endocrine: hypoglycemia.
• Momwe magazi amayendera: magazi m'thupi.
• Thupi lawo siligwirizana: totupa, urticaria.
• Metabolism: hypovitaminosis.
• Matumbo am'mimba: kusowa kwa chakudya, nseru, kulawa kwazitsulo mkamwa, kusanza, kutsekula m'mimba.

Ngati zotheka zimachitika, ndikofunikira kumwa mapiritsi kwakanthawi ndikupita kwa dokotala.

Malangizo a mankhwalawa akunena kuti kayendetsedwe kabwino sikulimbikitsidwa pazinthu izi:

• wodwala matenda ashuga
• ketoacidosis
• pulmonary / mtima kulephera,
• matenda a chiwindi osachiritsika
• myocardial infaration
• Hypersensitivity pamagawo a mankhwala,
• mimba ndi mkaka wa m`mawere.

Mosamala kwambiri, muyenera kugwiritsa ntchito "Glyformin" kuchokera ku shuga mellitus mu pathologies a matenda opatsirana, musanagwire ntchito yayikulu.

Malinga ndi malangizo, kugwiritsa ntchito nthawi imodzi ndi insulin, mankhwala osapweteka a antiidal, sulfonylureas, beta-blockers, kuchuluka kwa Glyformin sikuwonetsedwa.

Kuchita kwake kumatha kuchepa motsutsana ndi maziko a chithandizo chowonjezera ndi glucocorticosteroids, kulera kwapakamwa, mahomoni a chithokomiro, zotumphukira za nicotinic acid.

Mankhwalawa amayenera kusungidwa kutentha mpaka madigiri 25 pamalo otetezedwa kwa ana. Moyo wa alumali ndi zaka zitatu, ndipo mapiritsi azovala za filimu - zaka ziwiri.

Kodi ndalama zikufanana ndi chiyani? Mu matenda ashuga, mtengo wa mankhwala umagwira gawo lofunikira kwa odwala ambiri. Mankhwala omwe afotokozedwa m'nkhaniyi ndi otsika mtengo. Poika mapiritsi m'mapulogalamu amaola ayenera kulipira ndalama zopitilira 300 ma ruble. Mapiritsi okhala ndi chamfer olekanitsidwa (0,5 g yogwira ntchito) ndiotsika mtengo - pafupifupi ma ruble 150.

Mankhwala "Glyformin" akagulidwa, gwiritsani ntchito, malangizo, onani - ichi ndi chinthu choyamba chomwe odwala amalabadira. Chifukwa chazinthu zingapo zotsutsana, mankhwala sakhala oyenera ambiri. Mutha kusankha mankhwalawa ofanana ndi mankhwalawa atatha kufunsa dokotala.

Pakati pazofanizira zomwe zimagwirizana kwambiri ndi Gliformin malinga ndi zomwe zili pazomwe zimagwira, zotsatirazi ndizosiyanitsidwa: Diaberite, Metformin, Glukoran.

Odwala ambiri omwe amadziwika kuti amamwa mankhwalawa amauza munthu wina kuti ali ndi bongo wambiri. Nthawi zambiri, zimachitika chifukwa chogwiritsa ntchito mankhwalawa mosayenera. Mankhwala osokoneza bongo amatha kuyambitsa kupezeka kwa lactic acidosis. Zizindikiro zake zazikulu ndi: kupweteka kwa minofu, kusanza ndi mseru, kusokonezeka kwa chikumbumtima. Ngati wodwalayo ali ndi zizindikilo zotere, ndikulimbikitsidwa kusiya kumwa mankhwalawa ndikupempha thandizo kwa dokotala.

Kumbali ya akatswiri, ndemanga zambiri zimakhala zabwino. Ichi ndichifukwa chake Glyformin nthawi zambiri amalembera odwala matenda ashuga. Mtengo wa mankhwalawa ndi wotsika, ukhoza kugulidwa pa mankhwala aliwonse. Mukamatsatira malangizo mosamala, mwayi wokhala ndi zotsatirapo zake ndizochepa. Madokotala amachenjeza kuti munthawi yonse ya chithandizo ndikofunikira kuyesedwa kwa serum creatinine katatu pachaka. Pa mankhwala, mowa ndi mankhwala okhala ndi Mowa zimayenera kutayidwa.

Matenda a shuga ndi matenda ofala, omwe masiku ano akupezekanso kwambiri kwa achinyamata. Chithandizo chake, madokotala amatipatsa mankhwala osiyanasiyana. "Glyformin" amatanthauzanso iwo. Awa ndi mankhwala a hypoglycemic omwe amachititsa kuti khungu lizilimbitsa thupi. Ngati mukumvera malingana ndi malangizo komanso monga momwe dokotala wakupangirirani, payenera kukhala mavuto ena. M'pofunikanso kuganizira za zotsutsana za mankhwalawa.

Momwe mapiritsi a Glyformin amagwirira ntchito

Mu zaka zochepa, dziko lapansi lidzakondwerera zaka zana za metformin. Posachedwa, chidwi cha zinthu izi chikukula mwachangu. Chaka chilichonse, amawulula zinthu zodabwitsa zambiri.

Kafukufuku awulula zotsatirazi zabwino za mankhwala omwe amapezeka ndi metformin:

1. Kuchepetsa shuga m'magazi mwa kukonza minyewa. Mapiritsi a Gliformin ndi othandiza makamaka kwa odwala onenepa.
2. Kuchepa kwa shuga kwa chiwindi, komwe kumakupatsani mphamvu yolimbitsa glycemia. Pafupifupi, shuga m'mawa amachepetsedwa ndi 25%, zotsatira zabwino zimakhala za anthu odwala matenda ashuga omwe ali ndi matenda apamwamba kwambiri a glycemia.
3. Kuchepetsa kuyamwa kwa glucose kuchokera m'matumbo am'mimba, kuti kukhazikika kwake m'magazi sikufike pamitengo yapamwamba.
4. Kukondoweza kwa mapangidwe a shuga m'malo a glycogen. Chifukwa cha depot ngati odwala matenda ashuga, chiopsezo cha hypoglycemia chimachepa.
5. Kuwongolera kwa lipid mawonekedwe amwazi: kuchepa kwa cholesterol ndi triglycerides.
6. Kupewa matenda a shuga pamitsempha yamagazi.
7. Zothandiza pamanenepa. Pamaso pa insulin kukana, Gliformin itha kugwiritsidwa ntchito bwino pakuchepetsa thupi. Zimatheka chifukwa chochepetsa insulini m'magazi, zomwe zimalepheretsa kuchepa kwamafuta.
8. Glyformin ali ndi anorexigenic. Metformin, polumikizana ndi mucosa wam'mimba, imayambitsa kuchepa kwa chilimbikitso ndi kuchepa kwa kuchuluka kwa chakudya chomwe mumadya. Ndemanga yochepetsa thupi ikuwonetsa kuti Glyformin amathandizira kuti aliyense asamachepetse thupi. Ndi metabolism yokhazikika, mapiritsi awa ndi osathandiza.
9. Imfa pakati pa odwala matenda ashuga omwe amamwa mankhwalawa ndi 36% yotsika kuposa odwala omwe amalandila chithandizo china.

Zomwe zili pamwambapa zamankhwala zatsimikiziridwa kale ndipo zimawonekera mu malangizo ogwiritsira ntchito. Kuphatikiza apo, mphamvu ya antitumor ya Gliformin idapezeka. Ndi matenda a shuga, chiopsezo cha khansa ya m'matumbo, kapamba, bere ndi 20-50% kuposa. Mu gulu la odwala matenda ashuga omwe amathandizidwa ndi metformin, kuchuluka kwa khansa kunali kotsika poyerekeza ndi kwa odwala ena. Palinso umboni kuti mapiritsi a Gliformin amachedwetsa kuyambika kwakusintha kwam'badwo, koma izi sizinatsimikizidwe mwasayansi.

Zisonyezero zakudikirira

Malinga ndi malangizo, Gliformin akhoza kulembedwa:

• lembani matenda ashuga a 2, kuphatikiza odwala azaka 10,
• ndi matenda amtundu 1, ngati pakufunika kuchepetsa insulin,
• odwala metabolic syndrome ndi zovuta zina zomwe zimayambitsa matenda a shuga,
• anthu onenepa ngati atsimikizira insulin kukana.

Malinga ndi malingaliro a mabungwe apadziko lonse a shuga ndi Unduna wa Zaumoyo ku Russia, za matenda amitundu iwiri a shuga, mapiritsi okhala ndi metformin, kuphatikiza Glformin, akuphatikizidwa pamzere woyamba wa chithandizo. Izi zikutanthauza kuti amalembedwa choyambirira, ndikadzazindikira kuti kudya komanso kuchita masewera olimbitsa thupi sikokwanira kulipirira matenda ashuga. Monga gawo la mankhwala ophatikiza, Glformin imathandizira kuthandizira ndikuchotsetsa zovuta zomwe zimachitika chifukwa cha mankhwala ena.

Mlingo ndi mawonekedwe

Gliformin imapezeka m'mitundu iwiri. Mapiritsi a metformin achikhalidwe, 250, 500, 850 kapena 1000 mg. Mtengo wa mapaketi a mapiritsi 60 umachokera ku 130 mpaka 280 rubles. kutengera mlingo.

Fomu yosinthika ndikukonzekera kosinthika kwa Glyformin Prolong. Ili ndi Mlingo wa 750 kapena 1000 mg, wosiyana ndi Gliformin wanthawi zonse piritsi. Amapangidwa mwanjira yoti metformin imasiya pang'onopang'ono komanso moyenera, kotero, kufunikira kwa mankhwala m'magazi kumakhalabe tsiku lonse mutatha kumwa. Kuchulukitsa kwa Glyformin kumachepetsa mavuto komanso kumapangitsa kuti munthu amwe mankhwalawo kamodzi patsiku. Piritsi imatha kuthyoledwa pakati kuti muchepetse mulingo, koma sangaphwanyidwe kukhala ufa, popeza katundu omwe amakhala nthawi yayitali adzatayika.

Malangizowa akutsimikizira kusintha kwa Glformin kupita ku Glformin Pronge kupita kwa odwala matenda ashuga omwe metformin imadzetsa mavuto. Simuyenera kusintha mlingo. Ngati wodwala atenga Glformin pa mlingo waukulu, sangasinthe kwa mankhwala owonjezera.

Zotsatira zoyipa za mankhwalawa

Zotsatira zoyipa zomwe zimapezeka chifukwa cha mankhwalawa zimaphatikizanso kugaya chakudya. Kuphatikiza pa kusanza, mseru, ndi m'mimba, odwala amatha kumva kuwawa kapena zitsulo, kupweteka kwam'mimba pakamwa pawo. Kutsika kwakudyera ndikutheka, komabe, kwa mitundu yambiri ya 2 odwala matenda ashuga sangatchulidwe kuti ndi osafunika. Kumayambiriro kwa kugwiritsa ntchito mankhwalawa, zosasangalatsa zomveka zimawonekera mu 5-20% ya odwala. Kuti muchepetse, mapiritsi a Glformin amaledzera ndi chakudya, kuyambira mlingo wocheperako ndikuwonjezera pang'onopang'ono mpaka wabwino.

Kuphatikizika kwina kwa chithandizo ndi Glformin ndi lactic acidosis. Ichi ndi chikhalidwe chosowa kwambiri, ndipo malangizo ogwiritsira ntchito chiwopsezo akuyerekeza 0.01%. Choyambitsa chake ndi kuthekera kwa metformin kupititsa patsogolo kusweka kwa glucose pansi pamikhalidwe ya anaerobic. Kugwiritsa ntchito kwa Gliformin mu mlingo woyenera kungayambitse kuwonjezeka pang'ono chabe kwa lactic acid. Matenda ophatikizana ndi matenda amatha “kuyambitsa” lactic acidosis: ketoacidosis chifukwa cha matenda a shuga oopsa, chiwindi, matenda a impso, minofu hypoxia, kuledzera.

Mavuto abwinobwino chifukwa chogwiritsidwa ntchito kwa nthawi yayitali mankhwalawa ndi kuchepa kwa mavitamini B12 ndi B9. Nthawi zambiri, pamakhala zovuta zina zomwe zimabwera ndi Glformin - urticaria ndi kuyabwa.

Doctor of Medical Science, Mutu wa Institute of Diabetesology - Tatyana Yakovleva

Ndakhala ndikuphunzira matenda a shuga kwa zaka zambiri. Zimakhala zowopsa anthu ambiri akamwalira, ndipo makamaka amakhala olumala chifukwa cha matenda ashuga.

Ndithamangira kunena mbiri yabwino - Endocrinological Research Center ya Russian Academy of Medical Sayansi yakwanitsa kupanga mankhwala omwe amachiritsa odwala matenda ashuga mellitus. Pakadali pano, kugwiritsa ntchito bwino kwa mankhwalawa kuyandikira 98%.

Nkhani ina yabwino: Unduna wa Zaumoyo wateteza kukhazikitsidwa kwa pulogalamu yapadera yomwe imalipira mtengo wa mankhwalawo. Ku Russia, odwala matenda ashuga mpaka Meyi 18 (kuphatikiza) nditha kuipeza - Kwa ma ruble 147 okha!

Analogs ndi choloweza

Ma Analogs a Glformin wamba

Glyformin Kupitiliza kufanana

Malinga ndi odwala matenda ashuga, mankhwala odziwika bwino a metformin ndi French Glucophage ndi Germany Siofor. Ndi omwe omwe endocrinologists amayesa kupereka. Zomwe ndizofala kwambiri ndi Russian metformin. Mtengo wa mapiritsi am'nyumba ndi wotsika kuposa omwe amachokera kunja, kotero nthawi zambiri iwo amagulidwa ndi zigawo kuti agawidwe kwa odwala matenda ashuga.

Glformin kapena Metformin - zomwe zili bwino

Adaphunzira kupanga Metformin ngakhale ku India ndi China, osatchula Russia ndi zofuna zake zapamwamba za mankhwala. Opanga manyumba ambiri amapanga mitundu yayitali yamakono. Kapangidwe kabwino kamapiritsi komwe kamangolembedwa ku Glucofage Long. Komabe, ndemanga zikunena kuti pochita palibe zosiyana ndi mankhwala ena ochulukirapo, kuphatikiza Glformin.

Mapiritsi okhala ndi metformin yogwira ntchito pansi pa dzina lomweli amapangidwa ndi Rafarma, Vertex, Gideon Richter, Atoll, Medisorb, Canonfarma, Izvarino Pharma, Promomed, Biosynthesis ndi ena ambiri. Palibe chilichonse mwa mankhwalawa chomwe chinganenedwe kukhala choyipa kwambiri kapena chabwino. Onsewa ali ndi mawonekedwe ofanana ndipo adakwanitsa kuperekera kuwongolera kwapamwamba.

Zotsatira zoyipa ndi bongo

Kugwiritsa ntchito kwa Gliformin mu shuga kungayambitse mavuto.

Zomwe zikuluzikulu ndi izi:

• kulumikizana
• thupi lawo siligwirizana
• kulawa kwazitsulo mkamwa
• mavuto m'mimba.

Ngati simutsatira malangizowo, bongo amatha kuchitika. Zotsatira zake zowopsa ndi lactic acidosis, chifukwa chomwe wodwalayo angafe.

Kukula kwake kumawonetsedwa ndi zizindikiro monga:

• kufooka
• kutentha pang'ono
• chizungulire
• kupsinjika
• kupumira msanga
• chikumbumtima.

Izi zikachitika, muyenera kufunsa dokotala. Ngati ndi chizindikiro cha lactic acidosis, Glformin iyenera kusiyidwa.

Kuyanjana Ndi Mankhwala Ndi Analogi

Ngati mugwiritsa ntchito mankhwalawa limodzi ndi mankhwala ena, mawonekedwe a machitidwe ake akhoza kusintha.

Gliformin amayamba kugwira ntchito molimbika ngati agwiritsidwa ntchito limodzi:

• insulin
• mankhwala osapweteka a antiidal
• beta-blockers,
• Mao ndi ACE zoletsa, etc.

Kuchepa mphamvu kwake kumawonedwa mukamagwiritsa ntchito glucocorticosteroids, mankhwala a mahomoni, njira zakulera pakumwa pamlomo, ndi zina.

Ndiosafunika kutenga Gliformin ndi cimetidine, chifukwa izi zimapangitsa kuti lactic acidosis ipangidwe.

M'malo mwa mankhwalawa, mutha kugwiritsa ntchito zida monga:

1. Glucophage. Gawo lake logwira ntchito limaphatikizidwanso metformin.
2. Metformin. Chithandizo ichi chikufanana kwambiri ndi Glformin, koma chiri ndi mtengo wotsika.
3. Forethine. Ndi imodzi mwanjira zotsika mtengo kwambiri.

Sikoyenera kuti musankhe mankhwalawa kuti mubweze Glformin nokha - izi zimafuna kusamala. Ndikwabwino kukaonana ndi katswiri.

Maganizo a odwala

Kuchokera pa ndemanga za odwala omwe akutenga Glformin, titha kunena kuti mankhwalawa amachepetsa shuga m'magazi a shuga, koma adanenapo za zotsatira zoyipa, zomwe zimapangitsa kuti zikhale zopanda nzeru kumwa popanda chifukwa (kuchepa thupi).

Dokotalayo adandipeza posachedwa ndimatenda a shuga ndipo adalimbikitsa a Glyformin. Ndimamwa katatu patsiku piritsi. Kukhala bwino kwapita patsogolo pang'ono, shuga abwerera mwakale, ngakhalenso kuchepetsa thupi.

Ndakhala ndi matenda a shuga kwa zaka 8, choncho ndidayesera mankhwala ambiri. Ndimagwiritsa ntchito Gliformin kwa miyezi iwiri, ndikumva bwino. Poyamba, panali kusowa kudya ndi mseru, koma patatha milungu ingapo thupi lidazolowera ndipo zidapita. Koma mankhwalawa sanathandize mchimwene wanga - ndinayenera kukana, chifukwa ali ndi kapamba.

Ndilibe matenda ashuga, ndinayesa Glformin kuti ndichepe. Zotsatira zake zinandidabwitsa. Kulemera, kumene, kunachepa, koma mavuto ake adazunzidwa. Kukana kugwiritsa ntchito.

Ndemanga kanema wa Metmorfin wogwira ntchito kuchokera kwa Dr. Malysheva:

M'mafakitala am'magawo osiyanasiyana, pakhoza kukhala kusiyana kwa mtengo wa mankhwalawa. Palinso kusiyana kwa mtengo kwa Gliformin wokhala ndi zinthu zosiyanasiyana zogwira ntchito. Pafupipafupi, mitengo imakhala motere: mapiritsi a 500 mg - ma ruble 115, 850 mg - 210 rubles, 1000 mg - 485 rubles.