Mildronate: malangizo ogwiritsira ntchito

Makapisozi olimba a gelatin olimba, oyera, okhala ndi purosesa yoyera ya hygroscopic yokhala ndi fungo labwino, zotumphukira, katoni

Yogwira ntchito:

Meldonium dihydrate, 250 mg kapena 500 mg

Othandizira:

Calcium wowonda, colloidal silicon dioxide, wowuma wa mbatata,

Kuphatikizika kwa kapisozi ya gelatin: titanium dioxide, gelatin

Mankhwala

Yogwira pophika mankhwala, meldonium dihydrate, imasintha kagayidwe kazinthu ndikuthandizira mphamvu zama minofu. Kukhala ma analogue opanga a gamma-butyrobetaine, omwe ali gawo limodzi lililonse m'thupi la munthu, amathandizira minofu ndi chitetezo chamthupi, amathandizira magwiridwe antchito, amachepetsa zizindikiro za kupsinjika kwa thupi ndi malingaliro, komanso amakhala ndi mtima.

Mwa kuletsa gamma-butyrobetaine hydroxy kinase, chinthu ichi chimalepheretsa kuchulukana kwa acyl coenzyme A ndi acyl carnitine zotumphukira (mitundu yokhazikitsidwa yamafuta acid) m'magawo, zimachepetsa kaphatikizidwe ka carnitine, imachepetsa kayendedwe ka ma carnitine amthawi yayitali kudzera m'makoma a cell, kubwezeretsa mphamvu pakati pathupi, kubwezeretsanso mphamvu, kutulutsa mphamvu moyenera, kutulutsa mphamvu Kuyendetsa kwa ATF (kapena kuletsa kuphwanya kwake). Chifukwa cha kuchepetsedwa kwa carnitine, kupanga kwa gamma-butyrobetaine, komwe kuli ndi katundu wa vasodilating (vasodilating), kumalimbikitsidwa.

Meldonium dihydrate, yodziwika ndi zotsatira za mtima, imachepetsa njira zomwe zimachitika mu myocardium, imachepetsa pafupipafupi kuukira kwa angina, imawonjezera kukana kwa thupi ndi zochitika zolimbitsa thupi.

Mu pachimake komanso matenda a ischemic matenda amitsempha yamagazi, mankhwalawa amathandizira kukonza magazi mu ischemic.

Imakhala ndi njira yothandizirana mu mtima komanso ya dystrophic pathologies a fundus, amachotsa zovuta zamagulu a ANS odwala omwe ali ndi kusiyanasiyana kwa odwala omwe ali ndi vuto loledzera, ndipo amalepheretsa magwiridwe antchito amkati mwa dongosolo lamanjenje.

Pharmacokinetics

Pambuyo pakukonzekera pakamwa, gawo lomwe limagwiritsidwa ntchito ndi mankhwalawa limatengedwa mwachangu kuchokera kumimba, ndikufika pazambiri za plasma pambuyo pa maola 1-2. The bioavailability wa Mildronate ndi 78%.

Meldonium dihydrate imapukusidwa makamaka mu chiwindi, ndikupanga ma metabolites awiri omwe amatsitsidwa mkodzo. Hafu ya moyo wa mankhwala ndi maola 3-6 (kutengera mlingo wa mankhwalawo).

Zizindikiro zogwiritsidwa ntchito

Mavuto athupi komanso amisala (kuphatikiza osewera),
Kuchepetsa ntchito
Zovuta zapakati komanso zovuta za kufalitsa kwa ubongo (cerebrovascular insufficiency, stroke),
Chithandizo chokwanira cha matenda amtima (cornearyial infarction, angina pectoris),
Dyshormonal cardiomyopathy,
Kulephera kwamtima kosalekeza
Kuledzera kwanthawi zonse.

Contraindication

Hypersensitivity (kusalolera) mwa zigawo za mankhwala,
Mimba komanso kuyamwa
Zofika zaka 18 (chifukwa chosowa deta),
Kuchulukitsa kwachulukidwe,
Kubwera kwa maluwa otulutsa zilonda zamkati,
Intracranial zotupa.

Mlingo ndi makonzedwe

Chifukwa cha kuthekera kwa Mildronate kukhala ndi gawo losangalatsa, ndikulimbikitsidwa kuti mudzatengemo m'mawa, mpaka maola 17 (mutagwiritsidwa ntchito kangapo patsiku).

Mu matenda a mtima (myocardial infarction, angina pectoris), komanso matenda osakhazikika mtima, mankhwalawa amalimbikitsidwa kuti agwiritsidwe ntchito ngati gawo limodzi la mankhwala osokoneza bongo 1-2 pa tsiku kwa masabata a 4-6. Mlingo watsiku ndi tsiku ndi 0,5-1 g.

Kwa odwala omwe ali ndi vuto laormormonitis, Mildronate amatchulidwa ngati mankhwala osokoneza bongo kwa masiku 12, 500 mg patsiku.

Pankhani ya matenda a sitiroko ndi kuchepa kwa magazi m'thupi, mankhwalawa amagwiritsidwa ntchito ngati gawo limodzi la mankhwala osokoneza bongo a 0.5-1 g katatu patsiku kwa masabata a 4-6.

Pochiza matenda osokoneza bongo okhathamira, Mildronate amatengedwa katatu pachaka (malinga ndi malingaliro azachipatala) monga gawo la zovuta mankhwala, 0,5 mg kwa masabata 4-6.

Ndi kupsinjika kwakuthupi ndi kwamalingaliro komanso kuchepa kwa ntchito yogwiritsira ntchito mankhwalawa, amatengedwa 2 pa tsiku 500 mg kwa masiku 10-14. Ngati ndi kotheka, mankhwalawa amabwerezedwa pambuyo pa masabata awiri ndi atatu.

Ochita masewera asanakaphunzitsidwe amalimbikitsidwa kutenga Mildronate 2 kawiri pa tsiku, 0,5-1 g asanaphunzitsidwe kwa masiku 14 mpaka 21 pakukonzekera ndi masiku 10 mpaka 14 pa mpikisano.

Odwala omwe ali ndi vuto lauchidakwa, ndi zizindikiro zochoka, mankhwalawa amadziwitsidwa pakamwa ngati mbali yovuta ya mankhwala, 0,5 ga 4 pa tsiku kwa masiku 7-10.

Kuyanjana kwa mankhwala

Mildronate imawonjezera mphamvu ya zamankhwala zam'magazi a mtima, mankhwala a antihypertensive, ndi ma coronary dilators.

Mankhwalawa angagwiritsidwe ntchito limodzi ndi mitundu yayitali ya nitrate, mankhwala othamanga, othandizira, anticoagulants, okodzetsa, bronchodilators ndi antianginal.

Mukatenga Mildronate osakanikirana ndi nitroglycerin ndi antihypertensive othandizira (omwe amangokhala mafupa a nifedipine ndi alpha-blockers), kukulitsa kwa ochepa hypotension ndi tachycardia ndikotheka.

Zotsatira zoyipa

Nthawi zina, kuwonetsedwa kwa thupi lawo siligwirizana (hyperemia, kuyabwa khungu, zidzolo, urticaria, angioedema),
Dyspepsia
Kuchepetsa kapena kuchuluka kwa kuthamanga kwa magazi,
Tachycardia
Kusokonekera,
Zofooka zambiri (kawirikawiri)
Eosinophilia (osowa kwambiri).

Malangizo apadera

Pa nthawi yobereka komanso nthawi yoyamwitsa, chifukwa cha kusowa kwa zomwe zimachitika pa mwana wosabadwa komanso thanzi la mwana, Mildronate sanalembedwe.

Odwala omwe ali ndi matenda a impso ndi hepatic ayenera kusamala makamaka akamamwa mankhwalawa kwa nthawi yayitali.

Zambiri pazokhudza makapisozi a Mildronate pakutha kuyendetsa magalimoto kapena kugwira ntchito yofunika chidwi ndi kuthamanga kwa malingaliro a psychomotor sizinazindikiridwe.

Mayina, mafomu omasulira, kapangidwe kake ndi Mlingo wa Mildronate

Pakadali pano, Mildronate akupezeka mitundu itatu:
1. Makapisozi oyikiritsa pakamwa
2. Manyuchi pakamwa
3. Njira yothetsera jakisoni (intramuscular, intravenous and parabulbar).

Kupezeka kwa mitundu itatu yonse ya Mlingo wa Mildronate kumaphatikizanso zinthu zomwezi - meldonium. Izi zimagwira wofatsa kapena trimethylhydrazinium propionate dihydrate. M'mayendedwe ena ogwiritsira ntchito mankhwala, dzina la yogwira mankhwala (INN) ndi meldonium, mwa ena limapepuka, ndipo mwa ena trimethylhydrazinium propionate dihydrate. Komabe, munthawi zonse tikulankhula za mankhwala omwewo, omwe amadziwika ndi mayina osiyanasiyana.

Makapu apamwamba a Mildronate amakhala ndi gelatin, titanium dioxide, silicon dioxide, calcium yofunda komanso wowuma wa mbatata ngati ma excipients. Njira yothetsera jakisoni ilibe zinthu zina zothandiza, chifukwa imangokhala ndi meldonium ndi madzi oyeretsedwa. Mildronate Syrup ili ndi zotsatirazi:

Methyl parahydroxybenzoate,
Propyl parahydroxybenzoate,
Propylene glycol,
Sorbitol
Glycerin
Citric Acid Monohydrate
Cherry Essence
Dye Allura Red (E129),
Dye Brilliant Black BN (E151),
Madzi oyeretsedwa.

Makapisozi amapezeka mu mitundu iwiri - 250 mg ndi 500 mg ya meldonium. Madziwo ali ndi 250 mg ya meldonium mu 5 ml, ndiye kuti ali ndi kuchuluka kwa 50 mg / ml. Njira yothetsera jakisoni ili ndi 100 mg ya meldonium mu 1 ml (100 mg / ml).

Makapu apamwamba a Mildronate nthawi zambiri amatchedwa mapiritsi. Komabe, popeza mankhwalawo alibe mawonekedwe amtundu wotere, mawu akuti "mapiritsi" amatanthauza mtundu wa Mildronate woperekera pakamwa, ndipo awa ndi makapisozi. Chifukwa chake, pankhaniyi, mapiritsi = mapiritsi. Mayina amafupikidwe nthawi zambiri amawonetsera kuchuluka kwa makapisozi, monga Mildronate 250 ndi Mildronate 500komwe chithunzi chikufanana ndi mlingo wa yogwira ntchito. Kupanga yankho la jakisoni m'moyo watsiku ndi tsiku, nthawi zambiri amagwiritsa ntchito mitundu yaying'ono, monga Mildronate jakisoni ndi Mildronate Ampoules.

Achire zotsatira za Mildronate

Mildronate imasintha kagayidwe ndipo imapereka mphamvu ya minofu, ndipo chifukwa cha izi imakhala ndi zotsatirazi zochizira:

Cardioprotective kwenikweni Kutetezedwa kwa maselo a mtima ku zisonkhezero zoipa ndikusintha mayendedwe awo
Antianginal zochita - Kuchepetsa kwa okosijeni wama cell a myocardial (chifukwa cha izi, ngakhale mpweya wocheperako womwe umaperekedwa munthawi ya ischemic ndikwanira kwa maselo am'mnyewa wamtima, omwe amachepetsa kupweteka kwambiri, amachepetsa pafupipafupi maukira a angina ndikuwonjezera kulolerana kwa kupsinjika kwakuthupi ndi kwamalingaliro),
Antihypoxic zotsatira - Kuchepetsa mavuto obwera chifukwa cha kuchepa kwa mpweya,
Angioprotective zotsatira - Kuteteza ndi kuonetsetsa kukhulupirika kwa malinga a mitsempha yamagazi,
Tonic zotsatira.

Kuphatikiza apo, Mildronate amachepetsa mitsempha ya magazi ndikuwongolera chitetezo cha cellular, zomwe zimapangitsa kuti thupi likane kukana ndi matenda oyambitsidwa ndi ma virus.

Mu minofu ya mtima, ubongo, ndi retina, Mildronate amagawa magazi ndikuwongolera magazi ochulukirapo kumadera omwe ali ndi vuto la oxygen, ndiko kuti, amagwira ntchito mikhalidwe ya ischemia. Chifukwa chake, kupezeka kwamwazi koyenera kumatheka, momwe ziwalo zonse kapena chiwalo, kuphatikiza omwe akudwala ischemia, amalandira mpweya wokwanira ndi michere.

Ndi katundu wowonjezereka, Mildronate imapereka malire pakati pa zosowa za okosijeni zama cell ndi kutulutsa kwake kwenikweni ndi magazi, ndiye kuti, zimapanga magwiridwe antchito omwe mpweya nthawi zonse umakhala wokwanira. Kuphatikiza apo, Mildronate imathandizira kuchotsedwa kwa zinthu zopangidwa ndi poizoni mu maselo ndikuziteteza kuti zisawonongeke.

Mukamagwiritsa ntchito Mildronate patatha maola ochepa pambuyo povunduka ndi mtima, mankhwalawa amachepetsa mapangidwe a minofu ya necrosis ndipo amapangitsa kuti nthawi yobwezeretsa ikhale yochepa kwambiri. Mu matenda a mtima ndi kulephera kwa mtima, Mildronate amathandizira mphamvu yam'magazi, amathandizira kulimbitsa thupi komanso amachepetsa pafupipafupi matenda a angina.

M'mavuto apakati komanso osagwirizana ndi kufalitsidwa kwamatumbo, Mildronate amasintha magazi kupita pamalowo, omwe adapezeka kuti ndi ischemic, ndiye kuti, akumva njala. Izi zimatheka chifukwa chakugawidwanso kwa kayendedwe ka magazi mokomera gawo lina laubongo lomwe likusowa kuperewera kwa oxygen.

Ndi kusiya kwa mowa komanso odwala omwe ali ndi chidakwa, Mildronate amachotsa zovuta zamagulu amanjenje (amathandizanso kunjenjemera, kuchepetsa kukumbukira, chidwi, kuthamanga kwa zimachitika, etc.).

Potengera momwe mankhwalawo amagwiritsidwira ntchito, thupi la munthu wathanzi limatha kupirira zinthu zambiri komanso m'nthawi yochepa kubwezeretsa mphamvu zake. Kuphatikiza apo, Mildronate mwa anthu athanzi amawonjezera magwiridwe antchito ndipo amachepetsa zizindikiro za kupsinjika kwa malingaliro ndi thupi.

Mapiritsi a Mildronate (Mildronate 250, Mildronate 500) ndi madzi

Mapiritsi ndi madzi ayenera kumwedwa pakamwa, musanadye kapena theka la ola mutatha kudya. Popeza mankhwalawa angayambitse kusokonezeka kwa psychomotor, mapiritsi ndi madzi ayenera kumwedwa. Ngati mukufunikira kutenga Mildronate katatu patsiku, ndiye kuti muyenera kugawa zikondwererozo kuti zotsalazo zizigwera pa 5 p.m. Kutenga mankhwalawa pambuyo pa 17.00 sikulimbikitsidwa, chifukwa zimakhala zovuta kwambiri kuti munthu agone chifukwa cha kukhumudwa kwa psychomotor. Ngati munthu agona mochedwa kuposa 24,00 usiku, ndiye kuti mutha kuchedwetsa mlingo womaliza wa Mildronate nthawi ina, koma mwanjira yoti mutatha kugwiritsa ntchito piritsi lomaliza kapena mlingo wa madzi, osachepera maola 4-5 asanagone.

Mapiritsi amayenera kutsukidwa ndi madzi ndi kumeza yonse, osasweka, osaluma kapena kufinya mwanjira ina iliyonse. Musanagwiritse ntchito iliyonse, madziwo amayenera kugwedezeka mwamphamvu kangapo kenako ndikutsegula kapu yamabotolo ndikuyezera kuchuluka kwake. Kuti mumathira manyowa oyenera, mutha kugwiritsa ntchito supuni yoyesera yomwe imapezeka mu phukusi kapena syringe yokhazikika ndi magawano popanda singano. Mlingo wofunikira umathiridwa mu supuni ndikuledzera. Mu syringe, muyenera kujambula kuchuluka kwa manyowa kenako kuthira mumtsuko winawake, mwachitsanzo, galasi, ndi zina zambiri. Sipuni ndi supuni yoyezera ziyenera kutsukidwa ndi madzi oyera mukatha kugwiritsa ntchito.

Ngati pazifukwa zina ndizosatheka kugwiritsa ntchito syringe kapena supuni yoyesera mwapadera, mutha kuyeza kuchuluka kwa madzi malinga ndi zigawo zotsatirazi:

Supuni imakhala ndi 5 ml amadzimadzi,
Supuni yotsekemera ili ndi 10 ml ya madzi,
Supuni muli 15 ml zamadzimadzi.

Ndiye kuti, mutha kungotenga supuni yomwe imakhala ndi manyowa oyenera ndikuthira mwa iwo.

Mlingo wapakati wamapiritsi ndi manyuroni a Mildronate ndi ofanana, ndipo 250 mg 2-4 kawiri patsiku. Komabe, kuchuluka kwa chithandizo, kuchuluka kwa kayendetsedwe ka nthawi komanso nthawi yayitali ya chithandizo kumatengera mtundu wa matenda kapena vuto lomwe Mildronate amagwiritsidwa ntchito. Komanso, magawo onsewa ndi ofanana kwa makapisozi ndi manyowa. Kusankhidwa kwa fomu ya mankhwalawa - mapiritsi kapena manyumwa, amachitidwa pawokha kutengera mawonekedwe a thupi la munthu ndi zomwe akufuna. Mwachitsanzo, ngati nkovuta kwa munthu kumeza makapisozi, ndiye kuti kuli bwino kutenga Mildronate mu mawonekedwe a madzi, ndi zina.

Ganizirani momwe zimafunikira kutenga madzi ndi mapiritsi a matenda osiyanasiyana.

Ndi khola angina pectoris Mildronate akulimbikitsidwa kumwa 250 mg (piritsi limodzi kapena 5 ml ya madzi) katatu pa tsiku kwa masiku atatu mpaka anayi. Kenako mankhwalawa amatengedwa pa mlingo womwewo (250 mg katatu patsiku), koma osati tsiku lililonse, koma 2 kawiri pa sabata, ndiye kuti, masiku onse atatu. Mwanjira iyi (amatenga kawiri pa sabata), Mildronate akulimbikitsidwa kuti aledzeretse kwa miyezi 1 - 1.5. Kupititsa patsogolo zotsatira ndikukwaniritsa kusintha kwachipatala kotchuka kwambiri, Mildronate akulimbikitsidwa kuti aphatikizidwe ndi nitrate omwe amakhala ndi nthawi yayitali, monga Deponite, Cardicet, Mono Mack, etc.

Ndi osakhazikika angina ndi chatsopano myocardial infaration patsiku loyamba, Mildronate amathandizidwa ndi 500 mg000 mg, kenako amamuthira mankhwala mkati momwe amapangira mapiritsi kapena madzi. M'masiku oyambira atatu mpaka anayi, muyenera kumwa mankhwala a 250 mg (piritsi 1 kapena 5 ml ya madzi) kawiri pa tsiku. Kenako amasintha kumwa Mildronate 250 mg katatu patsiku masiku atatu alionse, ndiye kuti, kawiri pa sabata. Chifukwa chake, mankhwalawa amatengedwa kwa milungu 4 mpaka 6.

Mu pachimake koronare wamagazi kulephera kumapeto infarction nthawi Ndikulimbikitsidwa kumwa Mildronate 250 mg 2 kawiri pa tsiku kwa masabata atatu mpaka 6. Munthawi imeneyi, Mildronate samangokhala mankhwala othandizira omwe amangoyenera kugwiritsidwa ntchito ngati gawo la zovuta mankhwala. Simungasinthe Mildronate ndi mankhwala ena.Komanso, ngati pazifukwa zilizonse ndizosatheka kutenga Mildronate, ndiye kuti ndizotheka kuchita popanda izi.

Ndikumva kupweteka mumtima motsutsana ndi maziko a dishormonal myocardial dystrophy Mildronate iyenera kumwedwa pa 250 mg (piritsi 1 kapena 5 ml ya madzi) kawiri pa tsiku kwa masiku 12.

Mu ngozi pachimake cerebrovascular M'masiku 10 oyamba, Mildronate amathandizira kudzera m'mitsempha, kenako amamuthamangitsa kuti atenge mankhwalawo mkati momwe amapangira mapiritsi kapena madzi. Mildronate iyenera kumwa pakamwa pa 500 mg (mapiritsi 2 kapena 10 ml ya madzi) kamodzi patsiku kwa milungu 4 mpaka 6.

Panthawi ya ngozi cerebrovascular Mildronate imatha kumwa pakamwa pa 250 mg (piritsi limodzi kapena 5 ml ya madzi) katatu pa tsiku kwa masabata a 4-6. Maphunziro oterewa amachitika mobwerezabwereza katatu pachaka.

Pa matenda aliwonse omwe ali pamwambapa omwe amapezeka m'magazi kupita ku ubongo ndi matenda amtima, mutha kumwa Mildronate kawiri pa tsiku kapena kumwa kumwa wonse tsiku lililonse m'mawa. Mwachitsanzo, ngati zikuwonetsedwa kuti muyenera kumwa 250 mg katatu pa tsiku, ndiye kuti mutha kumwa mlingo wonse wam'mawa nthawi imodzi - 750 mg ya Mildronate.

Ndi mphumu ya bronchial ndi bronchitis Mildronate tikulimbikitsidwa kuti atengedwe ngati gawo la zovuta mankhwala pa 250 mg (piritsi 1 kapena 5 ml ya madzi) kamodzi patsiku kwa masabata atatu. Kuphatikiza pa Mildronate, munthu ayenera kugwiritsa ntchito bronchodilators (mwachitsanzo, Ventolin, Berotek, ndi zina) komanso mankhwala othandizira kutupa (mwachitsanzo, Intal, Flixotide, Pulmicort, ndi ena otero).

Mu uchidakwa wambiri Mildronate tikulimbikitsidwa kuti kumwedwa pakamwa 500 mg (piritsi 1 kapena 10 ml ya madzi) kanayi pa tsiku kwa masiku 7 mpaka 10. Maphunziro oterewa amatha kubwerezedwa nthawi ndi nthawi, kusungitsa nthawi yayitali pakati pawo kwa miyezi iwiri kapena iwiri.

Pazovuta zapamwamba kapena zaluntha kapena kuchira mwachangu pambuyo pa ntchito, kuphatikizapo othamanga, tikulimbikitsidwa kumwa Mildronate 250 mg (piritsi 1 kapena 5 ml ya madzi) kanayi pa tsiku kwa masiku 10 mpaka 14. Maphunziro ofanana amtunduwu amatha kubwerezedwa masabata onse awiri kapena atatu.

Asanaphunzitsidwe kwakutali, komanso mpikisano, othamanga akulimbikitsidwa kuti atenge Mildronate 500-1000 mg (mapiritsi a 2-4 kapena 10-20 ml ya madzi) 2 pa tsiku theka la ola musanaphunzire. Maphunzirowa ayenera kugwiritsidwa ntchito kwa milungu iwiri kapena itatu munthawi yophunzitsira komanso masiku 10 mpaka 14 panthawi ya mpikisano.

Ndi neurocirculatory dystonia ndi myocardial dystrophy mwa achinyamata azaka 12 mpaka 16 Ndikulimbikitsidwa kugwiritsa ntchito madzi a Mildronate mu Mlingo umodzi, wowerengeredwa pamtundu wa 12,5 - 25 mg pa kilogalamu imodzi ya thupi patsiku, koma osapitirira 1000 mg. Mlingo wowerengeka tsiku lililonse umagawika m'magawo awiri ofanana ndipo amatengedwa kawiri pa tsiku. Mwachitsanzo, wachinyamata amakhala ndi thupi lolemera 50 kg. Chifukwa chake, Mlingo wa Mildronate wa tsiku ndi tsiku ndi 12,5 * 50 = 625 mg ndi 25 * 50 = 1250 mg, i.e. 625 - 1250 mg. Komabe, popeza mlingo woyenera wovomerezeka sioposa 1000 mg, kwenikweni mulingo wa tsiku ndi tsiku wa Mildronate wachinyamata wolemera makilogalamu 50 adzakhala 625 - 1000 mg. Gawani kuchuluka kwa mankhwalawa tsiku lililonse ndi 2 ndipo pezani: 625/2 = 312.5 mg ndi 1000 / = 500 mg. Ndiye kuti, wachinyamata wolemera makilogalamu 50 ayenera kupatsidwa 312.5 - 500 mg wa Mildronate manyowa 2 pa tsiku.

Popeza talandira kuchuluka kwa mankhwalawa mu mg, iyenera kusinthidwa kukhala ml kuti mudziwe kuchuluka kwa manyowa oti muyeza kwa wachinyamata nthawi imodzi. Izi zikuchitika pogwiritsa ntchito gawo:
250 mg mu 5 ml (uku ndi kuzunzidwa komwe wopanga),
312,5 mg mu X ml
X = 312.5 * 5/250 = 6.25 ml.

Ndiko kuti, 312.5 - 500 mg ikufanana ndi 6.25 - 10 ml ya madzi. Izi zikutanthauza kuti wachinyamata wolemera makilogalamu 50 ayenera kumwa 6.25 - 10 ml ya madzi 2 kawiri pa tsiku.

Pogwiritsa ntchito kuchuluka kwake, mutha kuwerengera kuchuluka kwa milliliters a madzi, omwe ali ndi kuchuluka kwazinthu zilizonse zogwira ntchito. Kuti muchite izi, m'chiwonetsero chake ndizosavuta kusintha kuchuluka kwa mg m'malo mwa 312.5 mg.

Njira yogwiritsira ntchito Mildronate mu achinyamata ndi milungu iwiri kapena itatu.

Ndi asthenic syndrome Mildronate tikulimbikitsidwa kuti kumwedwa pakamwa mu mawonekedwe a 250 mg (5 ml) 4 pa tsiku kwa masiku 10 mpaka 14. Ngati ndi kotheka, maphunzirowa atha kubwerezedwa pambuyo pa masabata awiri kapena atatu.

Zotsatira za pharmacological

Meldonium Ndi mankhwala opangidwa omwe ali ndi vuto lofanananso ndi γ-butyrobetaine (GBB, chinthu chomwe chimayambira pa oxytrimethylaminobutyric acid - chinthu chachilengedwe chofanana ndi vitamini, Mavitamini B).

Malinga ndi Wikipedia, meldonium yodziwika ndi kuthekera kosintha kagayidwe ndi mphamvu yama cell ndipo amagwiritsidwa ntchito ngati:

mochulukitsa,
antihypoxic,
angioprotective,
antianginalamatanthauza.

Njira yamachitidwe Meldonia Amazindikira osiyanasiyana ake pharmacotherapeutic katundu. Kuvomerezeka kwa mankhwalawa kumathandizira kuonjezera mphamvu, kumachepetsa kuwonongeka kwa malingaliro, malingaliro ndi kulimbitsa thupi, kumayambitsa minofu ndi chitetezo chamanyazi.

Odwala kulephera kwa mtima, imawonjezera mphamvu ya contractions minofu yamtimaamachepetsa pafupipafupi kugunda kwa mtima (kuukira angina pectoris), komanso zimakulitsa kulolerana kwa thupi kuchitanso zolimbitsa thupi.

Pankhani yavulala kwambiri myocardium ntchito Meldonia Imachepetsa kupangika kwa magawo a necrotic, imachepetsa kutalika kwa nthawi yokonzanso, imachepetsa kufalikira kwa magazi poyang'ana kuwonongeka kwa ischemic ndikugawa magazi mokomera dera la ischemic.

Ponyamula katundu wolemera meldonium Zimathandizira kubwezeretsa bwino pakati pa kayendedwe ka okosijeni kupita ku maselo ndi kufunika kwa maselo mmenemu, kumalepheretsa kuchuluka kwa zinthu za cell metabolism ndi zinthu za poizoni m'maselo, kuteteza maselo ndi ma cell ma cell kuwonongeka, kumathandizira thupi kubwezera mwachangu mphamvu zake zomwe zimasunga komanso zimasunga metabolism yayikulu kwambiri.

Kumasulira CNS, meldoniumbwino amachotsa ntchito kuwonongeka somatic and autonomic (odziyimira) zigawo zamanjenje zamanjenje, kuphatikizapo kuphwanya komwe kumatsatana achire syndrome Odwala omwe ali ndi vuto lauchidakwa.

Kuphatikiza apo, chinthucho chimakhala ndi phindu pamkhalidwewo. dystrophically zisinthidwe zotengera zam'mimbazomwe zimakuthandizani kuti mugwiritse ntchito mankhwalawa fundus mtima ndi dystrophic pathologies.

Kugwiritsa ntchito kwa Mildronate pamasewera

Mildronate ndi chida chomwe chimadziwika ndi kuthekera kokulitsa kulekerera kosiyanasiyana kwa kupsinjika kwakuthupi (zonse mwamphamvu komanso mosasunthika) komanso ntchito zaluntha, osati kokha pakuvulala kwa ischemic, komanso mwa anthu athanzi.

Mankhwalawa ndiwothandiza kwambiri kwa othamanga chifukwa cha zomwe amatha kupanga kuti azikhala ndi thanzi labwino. minofu yamtima ndi minofu ina ya thupi ndikuchepetsa kutopa, pomwe munthawi yomweyo kumakulitsa kuyenera kwa maphunziro a masewera.

Mosiyana ndi zomwe ambiri amakhulupirira, Mildronate sagwiritsidwa ntchito ngati chida chothandizira minofu. Ntchito yake pamasewera ndi zomanga thupi ndizosiyana: Mildronate kwa othamanga amawonetsedwa ngati prophylactic yomwe imalepheretsa kugwira ntchito kwambiri (kuphatikiza minofu yamtima) Kupitilira muyeso.

Kuphatikiza apo, pakuthandizira kuchotsa mwachangu zinthu zowonongeka kuchokera ku maselo ndikuthandizira kubwezeretsa mphamvu zama cell, Mildronate imayenda bwino kagayidwe pa ma cellular ndikuthamangitsanso kuchira kwa minofu ya osewera pambuyo pakuchita masewera olimbitsa thupi. Kuphatikiza apo, zomalizazi zimakhudza zonse katundu ndi katundu wazonyamula pama liwiro komanso / kapena kupirira kwa thupi.

Amakhulupirira kuti kugwiritsa ntchito Mildronate pamasewera kumatha kuputa mafuta chiwindi hepatosis. Komabe, zilibe maziko.

Mildronate amaletsa mafuta acids kuti asalowe mu cell ndipo motero amalepheretsa kuchuluka kwa mafuta kulowa chiwindi. Kuphatikiza apo, kuwotcha shuga kwambiri, thupi limagwiritsa ntchito kuchuluka kwa zinthu zopanda pake, zomwe ndi mafuta okha, mamolekyulu onse amapangidwa adenosine triphosphate (Ndiye kuti, kupanga mphamvu).

Meldonius sanali m'gulu loyendetsa zigawenga mpaka Januware 1, 2016, zomwe zidaloleza kuti azigwiritsidwa ntchito movomerezeka mwamasewera onse.

Komabe, ataletsa kugwiritsa ntchito ndalama World Anti-Doping Agency (Wada) kumayambiriro kwa chaka cha 2016, osewera ambiri, makamaka ochokera ku Russia ndi mayiko a CIS wakale, adapezeka kuti ali ndi mlandu wogwiritsa ntchito mankhwalawa. Mildronate adakhalanso mutu wankhonya waukulu pomwe Maria Sharapova adazindikira kugwiritsa ntchito dope ili pa Marichi 7, 2016.

Mildronate: mikangano

Zotsatira zosagwirizana ndi Mildronate (wamitundu yonse yotulutsira mankhwala):

kukulitsa chidwi chamunthu payekha Meldonia kapena chilichonse chothandiza cha mankhwalawo.
intracranial matenda oopsa, kuphatikiza chifukwa cha zotupa za intracranial komanso kufooka kwa venous.

Zotsatira zoyipa

Zotsatira zoyipa chifukwa chogwiritsa ntchito Mildronate zimachitika nthawi zambiri. Monga lamulo, amafotokozedwa ngati:

thupi lawo siligwirizana (redness, totupa, kuyabwa ndi kutupa),
Zizindikiro zam'masokuwonetsedwa pang'onopang'ono, kusanza, kusanza, kutentha kwam'mimba, kumva kukhuta m'mimba ngakhale mutakhala chakudya chochepa,
tachycardia,
kuchuluka kukondwerera
kuchepa kwa magwiridwe kuthamanga kwa magazi.

Malangizo ogwiritsira ntchito Mildronate

Nthawi zambiri mumatha kupeza mayankho a mafunso akuti "Kodi ndizotheka kupaka jakisoni wa Mildronate m'matumbo?" Kapena "Kodi nkotheka kupaka jakisoni intramuscularly?".

Malangizo ogwiritsira ntchito kuchipatala akuwonetsa kuti mankhwalawa opakidwa jakisoni amapangira makonzedwe amkati, ndipo makapisozi ndi mapiritsi amapangidwira kukonzekera pakamwa (pa os).

Mlingo wa pakamwa pakamwa uyenera kutengedwa wonse, osafuna kutafuna, kuphwanya, kapena kutaya zomwe zili m'mapilogalamu.

IV mildronate imayendetsedwa mu mawonekedwe omalizidwa. Mildronate iyenera kuperekedwa mosagwirizana ndi mankhwala ena, kuchepetsedwa ndi madzi amchere a sodium chloride sikufunika (komabe, nthawi zina amaloledwa).

Akalowetsedwa mu minofu, yankho la jakisoni limakwiyitsa ndipo limatha kupweteka m'malo mwake thupi lawo siligwirizana mderalo. Pachifukwa ichi, Mankhwala a Mildronate nthawi zambiri amalowetsedwa m'mitsempha.

Mildronate jakisoni: malangizo ogwiritsira ntchito, zomwe zimaperekedwa komanso momwe mungamwere jakisoni

Zisonyezo zakugwiritsa ntchito jakisoni wa Mildronate: wosakhazikika (wopita patsogolo) angina pectoris, myocardial infaration, fundus mtima pathologies ndi kuzungulira kwa ubongo.

Odwala ndi coronary syndrome mankhwalawa amapaka jekeseni mu mtsempha wa jekeseni wa 500-1000 mg kamodzi patsiku. Pambuyo pa izi, chithandizo chimapitilizidwa, kumwa mapiritsi kapena mapiritsi.

Odwala ndi fundus mtima pathologies mankhwalawa amathandizidwa ndi retrobulbarly (kwa eyebine) kapena subconjunctivally (pansi pa chigolopolo chakunja kwa 0.5 ml kwa masiku 10).

Odwala ndi kuzungulira kwa ubongo mu gawo la pachimake, yankho limalowetsedwa mu mtsempha kamodzi patsiku pa mlingo wa 500 mg. Kutalika kwa njira ya achire ndi masiku 10. Mankhwala ena amaperekedwa pogwiritsa ntchito mitundu ya pakamwa.

Odwala ndi kuzungulira kwa ubongo mu mawonekedwe osakhazikika, makonzedwe a Mildronate amasonyezedwa kamodzi katatu patsiku mlingo wofanana ndi 500 mg (kwathunthu - musanadye nkhomaliro). Kutalika kwa njira yochizira kuyambira pa milungu iwiri mpaka itatu.

Mapiritsi a Mildronate: malangizo ogwiritsira ntchito

Odwala ndi matenda a mtima dongosolo Mapiritsi a Mildronate ndi makapisozi amasonyezedwa limodzi ndi mankhwala. Mankhwala amatengedwa pa 500-1000 mg patsiku. Mlingo wonse ungatengere limodzi nthawi yomweyo ndikugawikana.

Monga lamulo, njira yochizira imatenga milungu 4 mpaka 6.

At makkalinochifukwa cha adormoni myocardiopathyMildronate amatengedwa kamodzi patsiku, piritsi limodzi la 500 mg kapena mapiritsi awiri a 250 mg.

Odwala ndi kuzungulira kwa ubongo Pambuyo kuthetsa zovuta pachimake, kugwiritsa ntchito mankhwala muyezo wofanana ndi 500-1000 mg patsiku kukuwonetsedwa. Tengani nthawi imodzi kapena muigawe iwiri.

Odwala ndi zovuta zamagazi aakulu mawonekedwe, tikulimbikitsidwa kumwa 500 mg wa Mildronate patsiku.

Kutalika kwa chithandizo kumasiyana 4 mpaka 6 milungu. Mwa lingaliro la adokotala, wodwalayo amatha kutumikiridwa maphunzirowa mobwerezabwereza (kawiri kapena katatu pachaka).

Kwa odwala omwe ali ndi zotumphukira za pathological, mankhwalawa amayenera kumwa 500 mg kawiri pa tsiku. Mlingo wolimbikitsidwa wa kuchuluka kwa nzeru ndi thupi pa thupi (kuphatikiza osewera) ndi 1000 mg, womwe uyenera kugawidwa pawiri.

Kutalika kwa chithandizo kuchokera masiku 10 mpaka 14. Ngati ndi kotheka, bwerezani maphunzirowa, mutakhazikika kwa milungu iwiri kapena itatu.

Munthawi yophunzirira, othamanga a Mildronate akulimbikitsidwa kuti azimwa kawiri patsiku muyezo wofanana ndi 500-1000 mg. Kutalika kwa njira yochiritsira pakukonzekera nthawi zambiri kumakhala kwa milungu iwiri mpaka itatu, munthawi ya mpikisano nthawi yake imasiyana masiku 10 mpaka 14.

Atkusiya mowa kwa odwala omwe ali ndi vuto lauchidakwa, Mildronate amayenera kumwedwa kanayi patsiku pa 500 mg. Kutalika kwa maphunzirowa ndi kuyambira masiku 7 mpaka 10.

Mulingo wovomerezeka tsiku lililonse umadziwika kuti ndi 2000 mg.

Kuchita

Mildronate ikhoza kuphatikizidwa ndiantianginal, antiarrhythmic, anticoagulant, antiaggregant ndi okodzetsamankhwala mtima glycosides, bronchodilators ndi mankhwala ena.

Mildronate amatha kuyambitsa zochitika Nitroglycerin, β-adrenergic blockers, nifedepine ndi mankhwala ena omwe ali nawo coronarolytic kanthu, antihypertensive mankhwala, komanso ndalama zomwe zochita zawo zimayang'aniridwa zotumphukira vasodilation.

Chifukwa cha kuthekera kotukuka kwapakati tachycardia ndi magwiridwe antchito kuthamanga kwa magazigwiritsani ntchito ndalama zomwe zili pamwambazi limodzi ndi Mildronate ziyenera kugwiritsidwa ntchito mosamala.

Analogs of Mildronate

Analogs of Mildronate: Vazopro, Maluwa, Metamax, Methonate, Trizipine, Mildrakor, Mildrocard, Cardionate, Melfort, Idrinol, Riboxyl, Meldonium.

Mtengo wa analogues wa mankhwalawa umayamba kuchokera ku ma ruble a ku Russia okwanira 170.

Riboxin kapena Mildronate - ndibwino?

Riboxin Ndiwachilengedwe, kuphatikiza ziwalo za munthu.

Kukhala wotsogolera adenosine triphosphateImalimbikitsa mphamvu zamagetsi minofu yamtimakusintha kufalitsidwa, amachepetsa kuopsa kwa zotsatirapo zake intraoperative ischemic matenda aimpsoimalimbikitsa kupanga ma nucleotide ndi ntchito ya munthu payekha michere kuzungulira michere.

Chidacho chimakhudza njira za metabolic mkati minofu yamtima, zimawonjezera nyonga yamadongosolo ake ndipo zimamutsitsimutsa kupumuliratu diastole, yomwe imabweretsa kuwonjezeka kwa zizindikiro za CRI (kuchuluka kwa magazi a sitiroko).

Mildronate ali ndi vuto lofananalo, koma satenga nawo gawo pazinthu zina. Pankhaniyi, mankhwalawa amawongolera zochitika ndipo enzyme biosynthesisnawo mphamvu yopanga mphamvu, ndipo potero amateteza kagayidwe.

Mapeto ake ndi: Mildronate ndi mankhwala omwe zochita zake zimakonza njira za metabolic, Riboxin Zimatenganso mbali pazinthu zamitundu mitundu ndipo ndi njira yogwiritsira ntchito kagayidwe kazinthu.

Kuti mupeze zomwe zikuyembekezeredwa ndi pulogalamuyi Riboxin iyenera kuperekedwa muzinthu zofanana ndi zakumwa m'thupi. Ndipo popeza riboxin imagwiritsidwa ntchito ndi thupi pazochita zosiyanasiyana, imafunikira yambiri.

Mildronate, m'malo mwake, sichimadyedwa pakumachitika kwa metabolic, mphamvu yake imapitilira kwakanthawi, ndipo thupi lake limafuna zochepa kuposa Riboxin.

Chifukwa chake, kugwiritsa ntchito Mildronate kumathandizira kugwiritsa ntchito thupi Riboxin. Chifukwa chake, kugwiritsa ntchito mankhwalawa kuphatikiza kumathandizanso wina ndi mnzake.

Cardionate kapena Mildronate - ndibwino chiyani?

Cardionate ndipo Mildronate ndi mankhwala ofanana. Maziko ake ndi chinthu chimodzi chomwe chimagwira, motero onse omwe ali ndi kachitidwe kofananira.

Kusiyanitsa kokhako ndikuti, mosiyana ndi Mildronate Cardionate kupezeka kokha mwa mawonekedwe a 250 mg makapisozi ndi 500 mg / 5 ml jakisoni yankho.

Kuyenderana ndi mowa

Mankhwala othandizira a Mildronate amachotsedwa m'thupi pakatha maola 12, chifukwa chake, atatha nthawi imeneyi, chiopsezo cholumikizana ndi mankhwala ndi chinthu china chogwira ntchito ndizotsika kwambiri kapena kulibe.

Mwambiri, kumwa mowa munthawi ya mankhwala ndi Mildronate sikuletsedwa, komabe, ngati mankhwalawa amagwiritsidwa ntchito pochiza matenda amtima kapena ngozi yamitsempha, wodwalayo akulangizidwabe kuti aleke kumwa mowa.

Izi ndichifukwa choti mutamwa mankhwalawo limodzi ndi mowa, mutha kuwononga zotsatira zabwino zomwe zakwaniritsidwa pochiza matendawa.

Kumwa Mildronate ndi mowa kumatha kuyambitsa mkwiyo:

tachycardia,
kutchulidwa thupi lawo siligwirizana,
kusinthasintha kwa magazi,
Zizindikiro zam'maso.

Kusagwirizana bwino kwa Mildronate ndi mowa kumachitika chifukwa cha chiwopsezo chowonjezereka cha zovuta zosiyanasiyana komanso kuthekera kobwereranso kwa matendawa. Pachifukwa ichi, mowa sayenera kuperekedwa kwa nthawi yonse ya mankhwalawa.

Kugwiritsa ntchito kwa Mildronate pa mimba ndi mkaka wa m`mawere

Chitetezo pakugwiritsa ntchito Mildronate pochizira amayi apakati sichinatsimikizidwe. Kupatula mwayi wazovuta zake pakukula kwa mwana wosabadwayo, mankhwalaosati zotchulidwa pa mimba.

Sanakhazikike ngati meldonium kuyima kunja mkaka wa mayi woyamwitsa. Chifukwa chake, ngati mayi akuwonetsedwa chithandizo ndi Mildronate, munthawi yonse ya chithandizo chomwe akufuna siyani kuyamwitsa.

Ndemanga Zapamwamba

Ndemanga za Mildronate pamaforamu kwakukulu zabwino. Njira yapadera yothandizira mankhwalawa imalola kuti igwiritsidwe ntchito kwambiri kuthetsa mavuto ndi mtima, komanso chida chothandiza kuti anthu azikhala athanzi omwe amapanikizika pafupipafupi mwakuthupi komanso mwanzeru.

Ndipo odwala a m'madipatimenti a mtima, onse madokotala komanso othamanga amadziwa kuti Mildronate amakhumudwitsa ena. Poyerekeza ndi momwe ntchitoyo imagwirira ntchito, kukumbukira kumakhala kosinthika kwambiri, njira zamaganizidwe zimathandizira, kusuntha kwa kayendedwe, kupirira komanso kukana kwa thupi pazinthu zotsutsana kumawonjezereka.

Makasitomala amawunikira tsimikizani kuchuluka kwa kafukufuku wambiri, zomwe zidawonetsa kuti kugwiritsa ntchito Mildronate m'mabotolo ndi mawonekedwe a yankho la jakisoni amalola ochulukirapo nthawi zisanu ndi zinayi kuti achepetse kubwereza myocardial infaration.

Ndemanga za wodwala za Mildronate zimatilola kuona kuti mankhwalawa ndi othandizika kwa anthu omwe zochita zawo zimagwirizanitsidwa ndi kupsinjika kwa thupi, komanso nthawi yobwezeretsa pambuyo pakumwa kwa nthawi yayitali, ndikumva kuwawa ndi kuwawa mumtima. VSD ndi ma pathologies ena mtima.

Kuyerekezera kwapakati pa chida ichi 4,8-5 pa mfundo 5.

Komabe, ndemanga zolakwika zokhudza Mildronate nthawi zina zimakumana. Ndikofunika kukumbukira kuti, monga mankhwala ena aliwonse, Mildronate amapereka zotsatira zabwino pokhapokha ngati mlingo wake ndi chithandizo chofanana chikusankhidwa molondola (ngati kuli koyenera).

Mtengo wa mankhwalawo mumsika wa Ukraine

Mtengo wapakati wa mapiritsi a Mildronate 250 mg ndi 214.1 UAH. Mtengo wa 5 ml Mildronate ampoules ndi 383.95 UAH. 500 mg makapisozi mtengo 323-325 UAH pa paketi iliyonse. Mildronate Gx amagulitsa pafupifupi 233-240 UAH.

Kuphatikizanso apo, jakisoni, mapiritsi ndi makapisozi Mildronate m'mafakitala a Kharkov kapena Odessa ndi otsika mtengo kuposa momwe amapangira mankhwala azigawo ambiri.

Kupanga ndi mawonekedwe a kumasulidwa

Makapisozi a gelatin olimba, kukula No. 1, oyera, makapisozi - oyera makristalo oyera okhala ndi fungo lokomoka, la hygroscopic.

chogwira ntchito ndi meldonium phosphate (500 mg / 1 piritsi),
zina zowonjezera - E421, wowuma wa mbatata, povidone, silicon dioxide, cellcrystalline cellulose, magnesium stearate.

Gulu la Clinical ndi pharmacological: mankhwala omwe amakongoletsa kagayidwe kazinthu zamagetsi.

Kodi chimathandiza Mildronate ndi chiyani?

Mildronate amagwiritsidwa ntchito ngati gawo la zovuta mankhwala:

kulephera kwa mtima
IHD (myocardial infarction, angina pectoris),
adalandir
ngozi zoopsa komanso zopweteka kwambiri za m'matumbo,
komanso zizindikiro za kusiya kwa odwala omwe ali ndi chidakwa.

Kuchepetsa magwiridwe
nthawi yogwira ntchito kuti muchepetse nthawi yokonzanso,
kupsinjika kwakuthupi
hemophthalmus,
chapakati pa retin vein thrombosis,
retinal hemorrhages osiyanasiyana etiologies, matenda oopsa komanso matenda ashuga retinopathy (kwa parabulbar makonzedwe),
aakulu bronchitis ndi mphumu bronchial (monga immunomodulator).

Mildronate jakisoni - malangizo ntchito

Mildronate solution imatha kuperekedwa kudzera m'mitsempha, intramuscularly kapena parabulbarno. Jekeseni wamkati amatanthauza kuti yankho limalowetsedwa mwachindunji m'mitsempha, ndiye kuti, imalowa m'magazi. Kubaya kwa mnofu kumatanthawuza kuti njira yothetsera vutoli imalowetsedwa mu minyewa ya minofu, kuchokera komwe imayamba pang'onopang'ono ndipo imayamba kulowa pang'onopang'ono. Jekeseni wa parabulbar amatanthauza kuti yankho lake limalowetsedwa m'manja mwa maso. Momwemo, jakisoni wamkati ndi intramuscular amagwiritsidwa ntchito pochiza matenda amtundu, ndi parabulbar - pokhapokha pochiza matenda a maso.

Mildronate jekeseni yankho limapezeka mu umodzi wokha wa 100 ml / ml ndipo umapangidwira ma intravenous, intramuscular or parabulbar management. Ndiye kuti, yankho lomweli limagwiritsidwa ntchito pa mtundu uliwonse wa jekeseni.

Ampoules okhala ndi yankho ayenera kutsegulidwa nthawi yomweyo jakisoni. Osasungiratu yankho poyera kapena mufiriji. Ngati vutoli ndi yankho litatsegulidwa pasadakhale ndikuyimirira kwa mphindi zoposa 20, ndiye kuti mankhwalawa sayenera kugwiritsidwa ntchito, ayenera kutayidwa ndikutsegulidwa kwatsopano.

Musanatsegule zochulukirapo, onani mosamala njira yothetsera mitambo, ma flakes ndi zina. Ngati alipo, ndiye kuti silingagwiritsidwe ntchito. Ngati jakisoni, njira yokhayo yoyenera ndi yomveka bwino yomwe ingagwiritsidwe ntchito.

Zingwe ziyenera kuchitika m'mawa, popeza Mildronate amakhala ndi zosangalatsa. Ngati pakufunika kupanga ma jakisoni angapo patsiku, ndiye kuti omaliza amapangidwa osachepera maola 4 - 5 asanagone.

Jakisoni wa mu mnofu amatha kuchitika pawokha kunyumba, ndipo jakisoni wamkati ndi parabulbar kokha kuchipatala kapena kuchipatala. Jakisoni wovomerezeka kunyumba ukhoza kuchitidwa ndi namwino wodziwa ntchito yake.

Mlingo ndi malamulo oyendetsera Mildronate kudzera m'mitsempha ndi m'mitsempha

Mlingo, kuchuluka kwa jakisoni komanso kutalika kwa yankho la intravenous ndi intramuscular management ya Mildronate ndi chimodzimodzi. Kusankha kwa jakisoni - kudzera m'mitsempha kapena mu mnofu, kumatsimikiziridwa makamaka ndi kuchuluka kofunikira kopezera matenda.

Chifukwa chake, ngati mukufuna kuti mankhwalawo achitepo kanthu msanga ndipo vutoli limachitika kwakanthawi kochepa, ndiye kuti yankho limaperekedwa kudzera m'mitsempha. Izi nthawi zambiri zimakhala zofunikira pachimake. Ngati kuli kofunikira kuonetsetsa kuti mankhwalawa atenga nthawi yayitali osakwiya msanga, zotsatira zake zimaperekedwa kudzera mwa intramuscularly. Izi nthawi zambiri zimakhala zovomerezeka pochiza matenda osakhazikika. Chifukwa chake, titha kufotokozera mwachidule kuti jakisoni wamkati amagwiritsidwa ntchito pazovuta, ndipo jakisoni wa intramuscular amagwiritsidwa ntchito pochiza matenda osachiritsika. Jakisoni wa parabulbar amagwiritsidwa ntchito pokhapokha ngati matenda a maso.

Mlingo wokhazikika wa mayankho amkati mwa jakisoni wamkati ndi mu mnofu ndi 500 mg patsiku (5 ml ya yankho), komanso parabulbar - 50 mg patsiku (0.5 ml). Komabe, mankhwalawa amatha kusiyanasiyana kutengera momwe munthu alili ndi mtundu wa matenda omwe mankhwalawo amagwiritsidwa ntchito. Ganizirani mulingo, pafupipafupi komanso kutalika kwa jakisoni wa intravenous ndi intramuscular wa Mildronate mu matenda osiyanasiyana.

Ndi osakhazikika angina pectoris kapena myocardial infarction Mildronate iyenera kutumikiridwa kudzera mu 500-1000 mg (5-10 ml ya yankho) patsiku. Mlingo uwu ukhoza kuthandizidwa panthawi imodzi kapena kugawidwa pawiri. Ndiye kuti, ngati munthu salekerera jakisoni bwino, ndiye kuti kuli bwino kulowa muyezo wa tsiku ndi tsiku wa 500-1000 mg imodzi. Ngati munthu nthawi zambiri amalekerera jakisoni wamkati, ndibwino kugawa muyeso wa tsiku ndi tsiku mu magawo awiri ndikuyika jakisoni wa 250-500 mg kawiri pa tsiku.

Zingwe ndizofunikira tsiku limodzi lokha, mutatha kusamutsa munthu kuti alandire Mildronate mwanjira ya mapiritsi kapena madzi. Komabe, ngati pazifukwa zina munthu sangathe kumwa mapiritsi kapena madzi, kapena kutha kwake kukhala kotsika chifukwa cha matenda am'mimba, ndiye kuti njira ina yoperekera chithandizo imapitilirabe ndi jakisoni wamkati. Pankhaniyi, mkati mwa masabata a 4-6, 500-1000 mg tsiku lililonse masiku atatu aliwonse omwe amayendetsedwa kale. Mlingo wa tsiku ndi tsiku umathanso kulowetsedwa panthawi kapena kugawidwa pawiri.

Kulephera kwa mtima kosatha Mildronate imayendetsedwa pamitsempha 500-1000 mg (5-10 ml ya yankho) kamodzi patsiku kapena intramuscularly pa 500 mg (5 ml ya solution) 2 kawiri pa tsiku kwa masiku 10-14. Akamaliza maphunzirowo a jakisoni wamkati kapena m'mitsempha, amasintha kutenga Mildronate ngati mapiritsi kapena manyumwa kwa milungu itatu kapena inayi.

Mu nthawi ya pachimake ya ngozi ya ubongo Mildronate amathandizidwa ndi 500 mg (5 ml) kamodzi patsiku kwa masiku 10. Zitatha izi, munthuyo amamugwiritsa ntchito mankhwalawo monga mapiritsi kapena madzi, kapena jakisoni wamitsempha. Jakisoni wamkati amatulutsa 500 mg (5 ml of solution) kamodzi patsiku kwa masabata awiri mpaka atatu.

Panthawi ya ngozi cerebrovascular Mutha kutenga Mildronate mu mawonekedwe a piritsi kapena jekeseni wamitsempha. Zikatero, kusankha njira yogwiritsira ntchito mankhwalawa (kumwa mapiritsi kapena jakisoni wamkati) kumatsimikiziridwa ndi zomwe munthu amakonda, komanso cholinga chake komanso momwe thupi limayamwa akamamwa mankhwala. Mwachitsanzo, ngati munthu sangameze mapilitsi, kapena samamwa kwambiri chifukwa cha matenda am'mimba, ndiye kuti ayenera kukonda jakisoni wamkati. Ngati palibe zoletsa kumwa mapiritsi, ndibwino kuti musankhe mankhwalawa pogwiritsa ntchito mankhwalawa.

Chifukwa chake, ngati patachitika ngozi yayikulu yotsika, ndikofunikira kuperekera 500 mg (5 ml yankho) ya Mildronate intramuscularly kamodzi patsiku kwa masabata awiri mpaka atatu. Njira ya mankhwalawa imatha kubwerezedwa katatu mpaka katatu pachaka.

Ndikumva kupweteka mumtima motsutsana ndi maziko a dishormonal myocardial dystrophy Mildronate imayendetsedwa pamitsempha 500-1000 mg (5-10 ml ya yankho) kamodzi patsiku, kapena intramuscularly pa 500 mg (5 ml ya solution) 2 kawiri pa tsiku kwa masiku 10-14. Ngati ululu utatha msanga utamaliza maphunziro a Mildronate jakisoni, mankhwalawa adapangidwira mapiritsi masiku ena 12.

Pankhani yakuchuluka kwamaganizidwe ndi thupi kapena kufulumizitsa kukonzanso pambuyo pakuchita opaleshoni Mildronate imatha kutumikiridwa kudzera m'mitsempha, intramuscularly kapena kumwa mapiritsi. Kusankhidwa kwa kayendetsedwe ka kayendetsedwe kake kumadalira pa zomwe zimachitika mu matenda amisempha. Mitsempha kapena intramuscularly, Mildronate amathandizira pa 500 mg (5 ml ya yankho) kawiri pa tsiku kwa masiku 10-14. Ngati ndi kotheka, njira ya mankhwalawa imabwerezedwa pakatha milungu iwiri kapena itatu.

Mu uchidakwa wambiri Mildronate imayendetsedwa ndi mtsempha wa magazi ndi zotupa zamanjenje. Pankhaniyi, 500 mg (5 ml ya yankho) amaperekedwa kawiri pa tsiku kwa masiku 7 mpaka 10.

Ndi matenda a ziwiya za fundus kapena dystrophy ya retina Mildronate imayendetsedwa ndi parabulbarno 500 mg (5 ml of solution) kamodzi patsiku kwa masiku 10. Pamaso pa njira yotupa m'maso, Mildronate imaphatikizidwa ndi intravenous kapena parabulbar ya mahomoni a corticosteroid (Prednisolone, Dexamethasone, Betamethasone, etc.). Ndipo ndi dystrophy ya retina, Mildronate amaphatikizidwa mwachikhalidwe ndi kugwiritsa ntchito mankhwala omwe amasintha microcirculation.

Mimba komanso kuyamwa

Kafukufuku wazinyama samakwanira kuti athe kuwunika momwe meldonium imakhalira ndi pakati, mimbayo / fetal, kubadwa kwa mwana, ndi chitukuko cha pambuyo pake. Chiwopsezo chomwe chilipo kwa anthu sichikudziwika, chifukwa chake sichigwiritsidwa ntchito panthawi yapakati.

Pokhudzana ndi kumeza kwa meldonium mkaka wa amayi mu milandu yomwe mankhwalawa amagwiritsidwa ntchito pakutsatsa, kuyamwitsa kuyenera kuyimitsidwa.

Zotsatira zoyipa

Mankhwala nthawi zambiri amaloledwa. Komabe, mwa odwala omwe ali ndi chidwi, komanso ngati mukuchulukitsa mlingo, zovuta zimatheka.

Zotsatira zoyipa zomwe zalembedwa pansipa zimasankhidwa malinga ndi magulu amachitidwe a gulu, ndipo gulu lotsatirali limagwiritsidwa ntchito posonyeza kuchuluka kwa zomwe zimachitika: nthawi zambiri (> 1/10), nthawi zambiri (> 1/100, 1/1000, 1/10 000,

Bongo

Palibe milandu ya bongo yomwe imanenedwapo. Mankhwalawa ali ndi poizoni wochepa ndipo samayambitsa zovuta zoyipa.

Zizindikiro, ngati kuthamanga kwa magazi, kupweteka mutu, chizungulire, tachycardia, kufooka kwakukulu ndikotheka.

Pankhani ya bongo wambiri, ndikofunikira kuwongolera ntchito ya chiwindi ndi impso. Ndi kuchepa kwakukulu kwa kuthamanga kwa magazi, njira ziyenera kugwiritsidwa ntchito kuwongolera kupanikizika.

Meldonium - analogues

Mildronate analogues ogulitsa mankhwala ogulitsa ali magulu awiri a mankhwala - masinthidwe ndi analogi okha. Ma Synonyms amatanthauza mankhwala okhala, momwemonso Mildronate, meldonium monga chinthu chogwira ntchito. Analogues amatengedwa ngati mankhwala omwe ali ndi zofanana zochizira, koma okhala ndi zinthu zosiyanasiyana zogwira ntchito.

Mankhwala otsatirawa ndi ofanana ndi Mildronate:

Angiocardyl jakisoni
Makapisozi a Vasomag ndi jekeseni
Jakisoni wa Idrinol
Makapisozi a Cardionate ndi jekeseni,
Makapu a Meldonium ndi Injection,
Makapu apakatikati,
Jakisoni wa Mildrakor (ku Ukraine kokha),
Makapisozi a Mildrocard (ku Belarus kokha),
Melfor makapisozi,
Makapisozi a Medatern.

Mankhwala otsatirawa ndi fanizo la Mildronate:

Angiosil Retard Mapiritsi,
Mapiritsi a Antisten ndi a Antisten MV,
Biosynth lyophilisate yankho la jakisoni,
Mapiritsi a Bravadin
Mapiritsi a Valeocor-Q10,
Mapiritsi a Vero-trimetazidine,
Jakisoni wa Histochrome
Mapiritsi a Deprenorm MV,
Mapiritsi a Dibicor,
Jekeseni wa Dinatone,
Mapiritsi a Doppelherz Cardiovital,
Esaphosphine lyophilisate ndi yankho lokonzekera,
Inosie-F ndi jakisoni wa Inosin-Eskom
Mapiritsi a Carditrim
Mapiritsi a Coraxan
Coroner pellets,
Coudevita makapisozi,
Kudesan amagwa
Mapiritsi a Medarum 20 ndi Medarum MV,
Makapu a Mexicoor ndi Jekeseni,
Mapiritsi a Metagard,
Sodium adenosine triphosphate (ATP) jekeseni,
Neoton lyophilisate yothetsera jakisoni,
Makapisozi a Orokamag,
Pedea Injection,
Mapiritsi a Predisin,
Mapiritsi a Preductal and Preductal MV,
Mapiritsi oyambira
Mapiritsi a Ranex
Makapisozi a Riboxin, mapiritsi ndi jakisoni,
Mapiritsi a Rimecor ndi Rimecor MV,
Mapiritsi a Taufon,
Mapiritsi a Triducard,
Makapisozi oyambira,
Mapiritsi a Trimectal MV,
Mapiritsi a trimeth
Mapiritsi ndi makapisozi a Trimetazide,
Mapiritsi a Trimetazidine ndi Trimetazidine MV,
Mapiritsi a Trmitard MV,
Ubinon makapisozi,
Firazir jakisoni
Mapiritsi ndi fosfaden wa Fosfaden,
Mapiritsi a Ethoxidol.

Ndemanga Zapamwamba

Pafupifupi kuwunikira konse kwa Mildronate kuli kwabwino, chifukwa chakugwiritsa ntchito bwino kwa mankhwalawa pokonzanso magwiridwe antchito a mtima. Magulu onse a ndemanga zabwino amatha kugawidwa m'magulu awiri - zokhudzana ndi kugwiritsa ntchito mankhwalawa matenda oyamba komanso kugwiritsa ntchito mankhwalawa pochotsa zovuta kapena kuchuluka.

Chifukwa chake, pa ndemanga zabwino zokhudzana ndi kugwiritsa ntchito mankhwalawa m'matenda oopsa, anthu amawonetsa kuti atenga kapena nthawi ndi nthawi kutenga Mildronate kwa michere-vascular dystonia, matenda oopsa, kulephera kwa mtima kapena angina pectoris. Ndi micros-vascular dystonia, Mildronate kwa miyezi itatu kapena isanu anasinthiratu momwe munthu amene wayiwala matenda ake panthawiyi. Zizindikiro za dystonia zikadzawonekeranso, anthu amamwa njira ya Mildronate ndipo amakhutira ndi zotulukazo.

Ndi matenda oopsa, angina pectoris ndi kulephera kwa mtima, Mildronate amatengedwa ngati gawo la zovuta mankhwala. M'mawunikidwe, anthu omwe amatenga Mildronate chifukwa cha matendawa adazindikira kuti mankhwalawa amathandizira kutopa, amachepetsa kupuma, kumva kutopa, kusataya chiyembekezo komanso kusakhala ndi chidwi, amachepetsa pafupipafupi ziwopsezo za angina, zimawonjezera kupirira kwathunthu kwa thupi komanso kulolerana kupsinjika kwa thupi ndi kwamalingaliro.

Anthu omwe adatenga Mildronate chifukwa cha magwiridwe antchito amitsempha yama mtima (mwachitsanzo, kuthamanga kwa magazi, kupweteka kwa mtima chifukwa cha kupsinjika kapena kupsinjika, kutuluka kwamaso pamaso pa nkhope posunthika kuchoka pampando wina kukaima, zina), zindikirani, kuti mankhwalawa mwachangu komanso kuthetseratu vuto lawo, m'malo mwa kutopa ndi kutopa, kupepuka, mphamvu, mphamvu, kumveka m'mutu ndi kufunitsitsa kukhala ndi moyo.

Ndemanga zambiri zimati Mildronat adathandizira kuthana ndi kupsinjika kwa m'maganizo ndi thupi, kuwonjezera mphamvu ndikuthandizira kuchira pambuyo pa ntchito. Osewera amadziwa kuti mukamagwiritsa ntchito Mildronate kumakhala kosavuta kupuma panthawi yophunzitsira aerobic ndipo kumawonjezera kupirira.

Ndemanga zoyipa za Mildronate sizimadzipatula ndipo zimayenderana ndi zomwe zimapangitsa kuti anthu azilephera kugwiritsa ntchito mankhwalawa, motero amakakamizidwa kusiya kugwiritsa ntchito mankhwalawa.

Makasitomala amawunikira

Ndemanga za akatswiri amtima zokhudzana ndi Mildronate ndizosiyana - onse ali ndi zoipa komanso zabwino. Kuyang'ana kosavomerezeka kwa a mtima kumachitika osati chifukwa cha kuwunika kwawo kwa mankhwalawa chifukwa cha momwe odwala awonera, koma ndi udindo wawo pokhudzana ndi mankhwala omwe ali ndi phindu la zasayansi. Chowonadi ndi chakuti madokotala omwe amalankhula molakwika za Mildronate ndi otsatira mankhwala omwe amachokera ku umboni, chofunikira kwambiri ndicho kufunika kotsimikizira zotsatira za mankhwala aliwonse pogwiritsa ntchito kafukufuku wasayansi. Zotsatira za Mildronate sizitsimikiziridwa ndi kafukufuku wotere, ndipo pazifukwa izi, othandizira omwe amachokera ku mankhwala amawona kuti ndi "chopanda pake" motero, amasiya zowunikira.

Komabe, gulu ili la madotolo limaphonya kuti mankhwala ambiri padziko lapansi alibe zotsimikizika mwasayansi ndipo ngakhale izi zikugwiritsidwa ntchito bwino. Kupatula apo, palibe bungwe lomwe limagwiritsa ntchito ndalama zochulukirapo kuti zitsimikizire momwe mankhwala amathandizira, omwe siwofunikira kwambiri pakuchiza matenda aliwonse, koma ndi gawo limodzi la zovuta kuchizira. Makampani opanga mankhwala kuchokera kumbali ya mankhwala omwe ali ndi umboni amalungamitsa ndikuwonetsa kuyesetsa kwa mankhwalawo okha omwe amapangidwa kuti azichiritsa matenda.

Ndipo palibe amene amaganizira mitundu yayikulu ya othandizira omwe ali ndi Mildronate, kuwonjezera apo, madokotala padziko lonse lapansi amawagwiritsa ntchito popanda umboni, ndipo pamaziko a mfundo yosavuta - kodi wodwalayo amathandizira kapena ayi, kodi mkhalidwe wake umasintha? Ngati mankhwalawo atha kuthandiza, chabwino, mutha kugwiritsa ntchito ndikuwona kuti ndi othandiza kwa anthu ena. Madokotala omwe amayandikira kuikidwa kwa Mildronate kuchokera pano adzakuthandizani - chabwino, koma ngati sichoncho - tidzayang'ana wina mankhwala, monga lamulo, ayankhule bwino za mankhwalawa. Kuyankha bwino kumachitika chifukwa chakuti Mildronate amathandizira odwala ambiri, motero, amagwira anthu ambiri osiyanasiyana.

Mimba komanso kuyamwa

Chitetezo chogwiritsidwa ntchito mwa amayi apakati sichinaphunziridwe, motero, pofuna kupewa zotheka pa mwana wosabadwayo, kugwiritsa ntchito mankhwala kwa amayi apakati kumatsutsana. Kutulutsa mkaka ndi momwe thanzi la mwana wakhanda silinaphunziridwe, chifukwa chake ngati kuli koyenera, kugwiritsa ntchito mankhwalawa kuyenera kusiya kuyamwitsa.

Terms a Tchuthi cha Pharmacy

Mankhwala abwino kwambiri pamavuto amtima ndi maso. Ndimatenga makapisozi a 500 mg kawiri pachaka, Zimathandiza kwambiri. Sichimayambitsa mavuto aliwonse. Ndikulangizani ndi arrhythmia, matenda ashuga. Ndipo ingosamalirani thanzi lanu kufikira mavuto atadza ...

Zaka zitatu zapitazo, kutopa kosalekeza kunawonekera ndikuchepa kwa akatswiri othandizira kupuma omwe adalamulidwa kumwa Mildronate. Maphunzirowa atatha, idayamba bwino, kupuma movutikira, mphamvu zidawonekera. Kwa zaka ziwiri, ndimagula kawiri zigawo za kapu ndi kumwa kuti ndipewe. Ndipo masiku atatu apitawa ndidagula ma Mildronate 500 mg makapisozi a kampani Grindeks m'mawa ndidatenga imodzi ndikupita kuntchito. Koma sanafikire. Poyimilira basi, mwadzidzidzi adayamba kudziwongola ngati nsomba pamtunda ndipo movuta kwambiri adafika mnyumbayo. Adatenga Eufelin Barely achoka piritsi ili. Tsopano sindikudziwa choti ndichite, kapena nkhaniyo ndiyopanga (ndikupanga ku Crimea ndipo tinali ndi othandizira ena tsopano ochokera ku Russia) kapena china.

Ndimamwa modabwitsa kawiri pachaka. Adotolo ananena kangapo kuposa pamenepo. Ndimamukumbukira pamene miyendo yake imaleka kuyenda. Mukubwera, koma si anu. Wochirayo anakaikira kuti mankhwalawa angathandize. Koma kenako adatinso amachotsa poizoni m'magazi, mwina ndichifukwa chake pali kusintha. Koma kwa thupi lonse, Mildronate imabweretsa zabwino. Koma tiyenera kuganizira tsankho lililonse. Mayi anga anapatsidwa jakisoni kuchipatala, kotero chilichonse m'maso mwake chidasanduka chofiira ndikudwala. Adachotsedwa mwachangu. Thanzi kwa inu nonse.

Inde, pali mankhwala omwe amakhudzidwa ndi momwe amagwira ntchito. Mildronate wakhala akuchita maphunziro opitilira chaka chimodzi ndipo ndekha ndikuwona momwe ubongo umayambira kugwira ntchito, kutopa kumachepa.

Dokotala adakhazikitsa modekha madandaulo a kutopa kwambiri, kufooka, kusokonezeka kwa kukumbukira. M'mbuyomu, izi sizinali, koma zaka, mwachiwonekere, katundu ndi wamkulu. Ndamwa maphunzirowa, zotsatira zake zikuwonekeratu, ndikumva bwino.

Mapeto ake sindinazione. zili bwino !!

Ndizo kwa aliyense amene amakhala kuntchito, chida ichi ndichofunika. Ndikudziwa kale tikakhala ndi ** kuntchito ndipo ndipita kukonzekera mofatsa pasadakhale. Ndipo sindine wopusa, ngakhale kumapeto kwa tsiku ndimatha kuyenda, ndipo isanadze.

Mildronate amathandizanso kuti ndizitha kulimbana bwino ndi ntchito pamene kufalikira kumachitika. Ndakhala ndikulitenga kwa chaka chachitatu kumapeto, tili nalo ngati chiyambi cha sukulu, kotero chisangalalo chimayamba, timalima kuyambira m'mawa mpaka usiku. Koma chifukwa cha Mildronate ndili ndi nthawi pachilichonse.

Ndimalandiranso kuti nthawi yotentha ndimavomereza Mildronate kuti athane ndi ntchito. Ndimayesetsa kumamwa pasadakhale kuti ndikonzekere kunena. Ndipo chowonadi chazindikira kuti kuyang'ana kwambiri zinthu zofunika ndikosavuta, ndipo kuyang'anira zonse ndikosavuta kuposa kale.

Chaka chapitacho, kwa nthawi yoyamba, ndinayesera njira iyi kuti ndiwonjezere chidwi changa. Tsopano, nthawi yakubwera, nthawi zonse ndimamwa Mildronate - njira yabwino kwambiri. Sikuti ndizotheka kutsatira zonse kuntchito, koma pofika madzulo pali mphamvu yopita kumakanema, mwachitsanzo.

Mildronate amandithandiza kukonzekera gawoli. Zimachitika pamaso panu chifukwa chomwe mukukhalira, mukupsinjika pafupifupi usiku wonse ndipo mukufunikira kuti mufotokozere zambiri, ndipo ndi mapiritsi awa ndikhululukirani katundu wotere.

Ndikuvomereza akaunti yantchito, makamaka munthawi yankhani, pomwe blockage idakhazikitsidwa. Eya, mutu Mildronat adalangiza kuti amawonjezera luso lake logwira ntchito ndikuteteza mtima ku nkhawa, zomwe ndizofunikanso.

Ndidaganiza zokhetsa Mildronate. Nditatsika, ndidafika kuchipatala ndili ndi ambulansi. Ndili ndi zaka 69 ndipo ndimaona kuti ndi lolembera anthu okalamba.

Zachabechabe zonsezi sizothandiza kwa iye. Sindinamwe mowa chaka chatha. Tsopano ndinayesanso. Pulse amadumphira pamutu. Ndipo chifukwa chiyani ali wabwino kwambiri ngati analogue ndi riboxin yake. Chisudzulo china.

Kodi ndizotheka kuzikonda? Ndidangowonda pang'ono kubereka ndipo ndikufuna kuwonjezera thupi zomwe ndidalangizidwa