Amoxicillin: malangizo ogwiritsira ntchito

Mankhwala apanga mankhwala ambiri omwe amagwiritsidwa ntchito pochiza mabakiteriya. Ndipo imodzi mwamankhwala odziwika bwino kwambiri a antibayotiki ndi amoxicillin. Mankhwalawa amagwiritsidwa ntchito pa matenda osiyanasiyana pakafunika kuthetsa microflora yomwe imayambitsa.

Kufotokozera kwa mankhwalawa

Amoxicillin anapangidwa kumayambiriro kwa zaka za m'ma 70. Awa ndi antibacterial mankhwala ochokera ku kalasi ya penicillin, yokhudzana ndi mankhwala a semisynthetic. Amoxicillin ali pafupi kwambiri ndi ampicillin, koma amasiyana ndi kukhalapo kwa gulu la hydroxyl. Izi zimapangitsa kuti mankhwalawa akhale opezekanso mukamamwa pakamwa (osati kudzera m'mitsempha). Amoxicillin amathanso kugonjetsedwa ndi madzi a m'mimba poyerekeza ndi ampicillin, omwe amachititsa kuti azitha kutuluka bwino m'mimba komanso m'mimba kwambiri.

Pambuyo pa utsogoleri, mtundu uwu wa penicillin umalowa mu minyewa yonse yamadzi ndi zinthu zina zamthupi, zomwe zimatsimikizira kuti ndi achire kwambiri. Palinso ubale wolumikizana pakati pa gawo limodzi ndi kuchuluka kwa thupilo m'thupi, ndiye kuti, kuwirikiza kawiri kumabweretsa kuwonjezeka kwachiwiri kwa chinthu. Pa 50-70%, amoxillin amamuchotsa impso, gawo lochepa chabe la mankhwala lomwe limatulutsidwa m'chiwindi.

Mankhwala ndi a antibacterial bactericidal othandizira. Mfundo ya zochita za amoxicillin imakhazikika paziwopsezo za ma michere ena omwe amapanga makoma a mabakiteriya. Popanda ma enzymes amenewa, makoma a cell amawonongedwa, ndipo mabakiteriya amafa.

Amoxicillin amagwira ntchito motsutsana ndi mitundu ingapo ya tizilombo, tonse tambiri ta gramu komanso gram. Komabe, machitidwe akewo ndiwopezeka paliponse, popeza pali tizilombo tomwe timagwirizana ndi zochita za amoxicillin. Makamaka, awa ndi mabakiteriya omwe amatha kupanga beta-lactamase, yomwe imalepheretsa maantibayotiki. Chifukwa chake, nthawi zambiri amoxicillin amapangidwa limodzi ndi clavulanic acid, yemwe amateteza amoxicillin ku beta-lactamase.

Komabe, amoxicillin wangwiro amagwiritsidwanso ntchito nthawi zambiri, ngakhale ndiwocheperako poyerekeza ndi kuphatikiza amoxicillin ndi beta-lactamase. Izi zikufotokozedwa, limodzi, ndi mtengo wotsika wa mankhwalawa, ndipo, kumbali zochepa, zoyipa zochepa.

Komanso zochizira matenda oyambitsidwa ndi Helicobakter pylori, kuphatikiza kwa amoxicillin ndi metronidazole kumagwiritsidwa ntchito.

Bacteria yemwe wakhudzidwa ndi amoxicillin:

nsomba
khalimotz,
streptococci,
Shigella
gonococci.

Kugwiritsa

Amoxicillin amagwiritsidwa ntchito pochiza matenda a mabakiteriya a ziwalo zotsatirazi:

chapamwamba kupuma thirakiti (pharynx, nasopharynx, mmero, matani),
kupuma kwapadera thirakiti (trachea, bronchi, mapapu),
Matumbo
ziwalo zoberekera
khungu.

Makamaka, adotolo atha kukulemberani mankhwala opatsirana matenda opatsirana a kupuma:

Amoxicillin amachepetsa kuwonetsa kwa matenda opumira kwambiri komanso amachepetsa nthawi yofunikira kuti achire.

Matenda a genitourinary system omwe amoxicillin angafotokozedwe:

cystitis
pyelitis
yade
pyelonephritis,
matenda amitsempha
chinzonono
endometritis.

Matenda am'mimba, momwe amoxicillin amagwiritsidwa ntchito:

cholecystitis
peritonitis
enterocolitis
cholangitis
matenda a typhoid
kamwazi
salmonellosis (kuphatikiza ndionyamula),

Kodi matenda a pakhungu ndi minyewa yofewa yomwe dokotala angalembemo amoxicillin:

leptospirosis,
erysipelas
impetigo
zotupa za bakiteriya.

Amoxicillin amagwiritsidwanso ntchito pochiza matenda otsatirawa:

Akaphatikizidwa ndi metronidazole, mankhwalawa angagwiritsidwe ntchito pochiza matenda am'mimba a zilonda zam'mimbazi. Poterepa, zinthu zonse ziwiri zogwiritsidwa ntchito zimayimitsa kuchepa kwa mabakiteriya omwe amayambitsa matenda awa. Amoxicillin akukhulupirira kuti akuletsa kukula kwa mabakiteriya okanira metronidazole.

Ndemanga za mankhwalawa zabwino. Odwala amadziwa kukwera kwake kwapamwamba, mtengo wololera komanso zotsatira zochepa zoyipa.

Kutulutsa Fomu

Amoxicillin amagulitsidwa kokha ngati mapiritsi kapena mapiritsi. Mitundu ya makina a makolo kulibe, chifukwa mankhwalawa amalowa mthupi kuchokera m'matumbo momwemo monga momwe amathandizira. Mapiritsi ndi makapisozi a mankhwala nthawi zambiri amakhala ndi mlingo wa 250 ndi 500 mg. Magawo okonzekera kuyimitsidwa kwa ana amapezekanso. Pali mitundu yambiri ya amoxicillin pamsika. Izi ndi mankhwala opangidwa ndi onse opanga aku Russia ndi ku Europe. Maunikidwe a kapangidwe kake ayenera kukhala ndi amoxicillin pakapangidwe kake. Komabe, ena mwa mankhwalawa atha kukhala ndi dzina losiyana.

Amoxicillin amasiyanitsidwa ndi mtengo wotsika mtengo. Itha kukhala pafupifupi ma ruble 30 pakompyuta iliyonse ya mapiritsi 10 ndi pafupifupi ma ruble 60 pa paketi 20 ya makapisozi. Ma granules pokonzekera kuyimitsidwa (ma PC 10. Pakiti iliyonse) imalinso ndi ma ruble 60. Alumali moyo wa amoxicillin ndi zaka zitatu. Itha kusungidwa pamalo amdima pa kutentha osaposa +25 ºС.

Contraindication

Amoxicillin ali ndi zotsutsana zochepa. Milandu yayikulu ikuphatikiza:

zaka mpaka zaka zitatu
trimester yoyamba ya mimba
yoyamwitsa
tsankho kwa amoxicillin ndi penicillin ena,
kulephera kwambiri kwaimpso
kugaya chakudya kwambiri,
matenda mononucleosis,
lymphocytic leukemia
Mphumu ya bronchial,
mbiri yokhudzana ndi ma colitis othana ndi antiotic.

Ndi kuphatikiza kwa ntchito amoxicillin ndi clavulanic acid, matenda owopsa a chiwindi amawonjezeredwa ndi zotsutsana izi.

Amoxicillin ndi metronidazole sangathe kugwiritsidwa ntchito limodzi paubwana. Ngakhale zaka zosachepera momwe amoxicillin angagwiritsidwe ntchito, malinga ndi malingaliro omwe wopanga, ali ndi zaka zitatu, komabe, madokotala a ana amagwiritsa ntchito amoxicillin kuchitira ana achichepere.

Kuyimitsidwa kumakhala ndi sucrose, izi ziyenera kulingaliridwa kwa anthu omwe ali ndi matenda ashuga.

Tiyenera kumvetsetsa kuti amoxicillin, ngati mankhwala aliwonse opha majakisoni, cholinga chake ndi kuchiza matenda obwera ndi mabakiteriya, komanso ngati pali kachilombo komwe kamayambitsa matenda - SARS, chimfine, herpes, kugwiritsa ntchito kwake sikungakhale kopanda pake, komanso kungavulaze.

Zotsatira zoyipa

Amoxicillin nthawi zambiri amaloledwa ndi odwala. Komabe, nthawi zina, mavuto osafunikira angachitike. Zotsatira zoyipa kwambiri ndizophatikizirapo:

nseru, dyspepsia,
kutsegula m'mimba
rhinitis
conjunctivitis
malungo
kusintha kwa magazi (eosinophilia, leukopenia, neutropenia), kuchepa magazi,
stomatitis
dysbiosis,
candidiasis
colpitis (mwa akazi),
mutu
thupi lawo siligwirizana (hyperemia, edema, urticaria, dermatitis, anaphylactic mantha),
tachycardia.

Zotsatira zamitsempha zam'mimba ndizothekanso (kusowa tulo, kukwiya, nkhawa, kusokonezeka).

Amoxicillin imatha kutha kuchepa kwa vitamini K. Komanso, kugwiritsa ntchito mankhwalawa nthawi zina kumabweretsa kutsika kwa index ya prothrombin.

Ndi chithandizo cha nthawi yayitali ndi amoxicillin, ndikofunikira kuti nthawi zina muwoneke mawonekedwe a chiwindi, impso ndi hematopoiesis.

Ndi bongo wa amoxicillin, kutsegula m'mimba kwambiri ndikotheka. Zizindikiro mankhwala osokoneza bongo, hemodialysis.

Amoxicillin, malangizo ntchito

Ngati pakufunika kutenga amoxicillin, malangizo ogwiritsira ntchito adzafotokozera zonse zofunikira. Mlingo wofanana wa amoxicillin uyenera kuwonetsedwa ndi adokotala. Pa matenda osiyanasiyana, ma Mlingo ndi mitundu yosiyanasiyana ndi yofunikira chifukwa chake kudzichiritsa kokhako sikuvomerezeka pano. Mulingo wambiri watsiku ndi tsiku wa amoxicillin ndi 6 g.

Malinga ndi malangizo ogwiritsa ntchito, mulingo woyenera wa akulu ndi ana opitilira zaka 10 wokhala ndi kulemera koposa 40 kg ndi 250-500 mg nthawi imodzi. Pazonse, amoxicillin amayenera kumwedwa katatu patsiku, atatha maola 8. Maudindo pakati pa Mlingo amayenera kusungidwa mosamalitsa momwe mungathere, popeza ichi ndi chitsimikizo chogwiritsira ntchito mankhwala othandizira omwe ali mthupi. Pankhani ya matenda oopsa, Mlingo wa amoxicillin ukhoza kuwonjezeka mpaka 1000 mg.

Kodi ana omwe ali ndi zaka zosakwana 10 amalimbikitsidwa? Pazaka izi, kuyimitsidwa kumakonda. Kuphatikiza apo, odwala ang'onoang'ono nthawi zonse amapereka mankhwala ochepera kuposa akuluakulu. Ana a zaka 5 mpaka 10 nthawi zambiri amapatsidwa 250 mg ya amoxicillin katatu patsiku, wazaka 2-5 - 125 mg katatu patsiku. Kwa ana ochepera zaka ziwiri ndi ana akhanda, Mlingo umayikidwa kutengera kulemera kwawo - 20 mg / kg patsiku. Mlingo wa amoxicillin uyenera kugawidwa m'magawo atatu.

Pochita zochizira, amoxicillin amatha kupatsidwa kwa ana, kuyambira milungu 4.

Kukonzekera kuyimitsidwa

Malinga ndi malangizo ogwiritsira ntchito, kukonza kuyimitsidwa kwa amoxicillin, onjezerani madzi ku zoopsa zomwe zili m'botolo, ndikugwedeza. Kuyimitsidwa komwe kumatha kusungidwa mu kutentha kwa firii mpaka milungu iwiri. Musanagwiritse ntchito chilichonse, bokosi liyenera kugwedezeka. Supuni yoyezera yomwe mankhwalawa amaperekedwa imakhala ndi 5 ml. Ngati yakonzedwa bwino, kuyimitsidwa kumayenera kukhala ndi 250 mg ya amoxicillin.

Anthu omwe ali ndi vuto la impso ndi kuchepetsedwa kwa creatinine chilolezo amafunikanso kusintha kwamankhwala pofika pansi. Kutalika kwa mankhwalawa ndi amoxicillin kumatsimikizidwanso ndi dokotala. Nthawi zambiri zimakhala pakati pa masiku 5 mpaka 14. Koma ngakhale wodwalayo akumva kusintha patatha masiku angapo amwa mankhwalawo, ndiye kuti simuyenera kusiya maphunzirowo (ndikofunika kuwonjezeranso masiku ena atatu), chifukwa izi zingayambitse matenda.

Pochiza matenda a chinzonono mwa amuna, muyezo umodzi wa mankhwalawo ndi wokwanira, koma muyezo waukulu wa 3. Mankhwalawa a chinzonono mwa akazi, amoxillin ayenera kumwedwa kawiri pa mlingo wa 3 g.

Mankhwalawa matenda opatsirana, monga typhoid fever, paratyphoid fever, zotupa za mabakiteriya, matenda ena amitsempha, ndikofunikira kumwa mankhwalawa 1.5-2 g katatu patsiku.

Leptospirosis amathandizidwa ndi mapiritsi kapena makapisozi a amoxicillin mu mlingo wa 0,5-0.75 g 4 pa tsiku kwa masiku 6-12.

Kuti muchotse salmonella pakakhala kuti salmonellosis (bacillus carriers), ndikofunikira kumwa mankhwalawa 1.5-2 g katatu patsiku kwa masabata 2-4.

Poletsa endocarditis musanachite opareshoni, akulu amapatsidwa 3-4 g ya amoxicillin kamodzi pa ola limodzi asanachite opareshoni. Mlingo wa ana ayenera kukhala osachepera theka.

Malinga ndi malangizo ogwiritsira ntchito, kudya samakhudzanso digestibility ya mankhwalawa, chifukwa chake amatha kuchitika mosasamala nthawi yakudya.

Njira ya mankhwala ndi amoxicillin akhoza limodzi ndi dysbiosis. Chifukwa chake, mutamaliza maphunzirowa, mwina pangafunike kubwezeretsa microflora yam'mimba mothandizidwa ndi ma proiotic.

Ngati kutsegula m'mimba kumachitika pakumwa mankhwalawo, ndiye kuti muyenera kupewa kumwa mankhwala omwe amachepetsa matumbo.

Kuchita ndi mankhwala ena ndi zinthu zina

Amoxicillin nthawi zambiri amayenda ndi mankhwala ena. Komabe, mankhwala ena amathandizanso kugwira ntchito kwake, moyenera komanso molakwika. Chifukwa chake, mwachitsanzo, monga momwe malangizowa akunenera, maantibayotiki amathandizira mphamvu ya mankhwalawa akamamwa. Koma mankhwala a bacteriostatic (macrolides, tetracyclines, sulfonamides), m'malo mwake, amawalepheretsa kuchita. Ndiye chifukwa chake sikulimbikitsidwa kugwiritsa ntchito amoxicillin molumikizana ndi gulu ili la mankhwalawa.

Zinthu zina (maantacidid, glucosamine, glycosides, laxatives) zimasokoneza mayamwidwe amo amoillillin, koma ascorbic acid, mmalo mwake, imathandizira panjira iyi. Amoxicillin imathandizira mayamwidwe a digoxin.

Mankhwala amachepetsa mphamvu ya njira yolerera yokhala ndi pakamwa ya estrogen, chifukwa chake, amayi omwe amagwiritsa ntchito njira yodzitetemera amayenera kugwiritsa ntchito njira zina za kulera panthawi ya mankhwalawa.

Tiyeneranso kukumbukira kuti simungathe kumwa amoxicillin limodzi ndi mowa, chifukwa izi zimawonjezera chiopsezo cha mavuto, komanso chiwindi ndi vuto la impso. Muyenera kupewa kumwa mowa ngakhale patangopita masiku ochepa chithandizo chatha.

Zisonyezero zogwiritsira ntchito amoxicillin ufa

matenda a chapamwamba kupuma thirakiti ndi ENT - ziwalo (kuphatikizapo pachimake ndi matenda sinusitis, pachimake ndi matenda otitis TV, pharyngeal abscess, tonsillitis, pharyngitis)

matenda a m'munsi kupuma thirakiti (kuphatikizapo pachimake bronchitis ndi bakiteriya wamphamvu, chifuwa, chibayo)

matenda a kwamkodzo thirakiti

matenda azamatenda

khungu ndi zofewa minofu matenda

matenda a mafupa ndi mafupa

matenda am'mimba, kuphatikizapo biliary thirakiti (cholecystitis, cholangitis)

matenda odontogenic

matenda opatsirana mwakugonana (gonorrhea, chancroid)

kupewa matenda pambuyo pa opaleshoni

tynys zholdarynyң zhғғargy bөlіkterіndegі zhne LOR aғzalardрy zhpalarda onyң іshіnde zhedel aғymdy zhine sozylmaly sinusitte, zhedel aғymdy zhne lezmylmala orta

tynys zholdarynyң tөmengі bөlіkterіndegі zhpalarda (onyң іshіnde bakterialyқ asқyn zhpasy bar zhedel aғymdy bronchitte, bronchitis wakwiya, chibayo)

nesep manyaziғaru zholdarynyң zhpalarynda

azachipatala

terіmen zhұmsaқ tіn zhpalarynda

Amuna a Sүekter buyn zhpalarynda

құүрсақ қуысының, оныі ішінде өт жолдарының жұқпаларында (cholecystitis, cholangitis)

odontogendі zhpalarda

zhynystyқ zholmen zhatyn zhpalarda (pangani, chancroid)

opaleshoni aralasymnan keying zhpalardyң aldyn aluғa

Zotsatira zoyipa za amoxicillin ufa

kutha kwa kudya, nseru, kusanza, kutsegula m'mimba, kawirikawiri: kuwonongeka kwa chiwindi, kuwonjezereka kwa ALT ndi AST, munthawi zina - cholestatic jaundice, hepatitis, pseudomembranous colitis.

thupi lawo siligwirizana, kuyabwa, urticaria, erythematous totupa, kawirikawiri: multiforme exudative erythema, angioedema, anaphylactic mantha, nthawi zina - exfoliative dermatitis, Stevens-Johnson syndrome.

kuchuluka kosintha kwa prothrombin nthawi (ikaphatikizidwa ndi anticoagulants), kawirikawiri: candidiasis ndi mitundu ina ya superinitness.

tebet zhogaluy, zhurek ainuy, құsu, ish өtu yқtimal, sirek: bauyr қyzmetіnің bұzyluy, ALT әne AST, belsendilіgіnің ғoғarylauy, jekelegen jadedudylarda, cholestate, cholestate.

allergals қ reactionar, қyshu, hesekzhem, erythematosis ө ө ө е

prothrombin uaқytynң қaitymdy tүrde artuy (anticoagulantarmen bіrіktіrіp қoldanғanda);

Malangizo apadera ogwiritsa ntchito

Pogwiritsa ntchito mankhwalawa, muyenera kuwunika momwe ntchito ya magazi, chiwindi, impso.

Chifukwa chakuti odwala ambiri omwe ali ndi matenda opatsirana a mononucleosis ndi lymphocytic leukemia omwe adalandira ampicillin, mawonekedwe a zotupa za erythematous adawonedwa, kugwiritsidwa ntchito kwa mankhwala ampicillin mwa odwala sikulimbikitsidwa.

Mankhwala ali ndi potaziyamu.

Odwala omwe ali ndi zakudya zopatsa mphamvu za sodium ayenera kudziwa kuti 600 mg vial (500 mg + 100 mg) ali ndi sodium 29.7 mg, lililonse la vial 1.2 g (1000 mg + 200 mg) lili ndi 59.3 mg sodium. Kuchuluka kwa sodium pazokwanira tsiku lililonse kuposa 200 mg.

Pogwiritsa ntchito Amoxicillin sodium ndi potaziyamu clavulanate pamitengo yayitali, zotsatira zoyipa zabodza ndizotheka pozindikira kuchuluka kwa shuga mumkodzo pogwiritsa ntchito yankho la Benedict kapena Felling's solution (enzymatic reaction ndi glucose oxidase).

Makonzedwe oyanjana ndi disulfiram ayenera kupewedwa.

Mimba komanso kuyamwa
Kukhazikitsidwa kwa mankhwalawa panthawi yapakati ndikotheka kokha ndikuwonetsa mwamtheradi. Amoxicillin sodium ndi clavulanic acid ochepa omwe amafukusidwa mkaka wa m'mawere. Pa nthawi ya chithandizo ayenera kusiya kuyamwitsa.

Mankhwalawa ndi kurspen қoldanғan keездеездеқan tүzu aғzalarynң, bauyrdyң, bүyrekterdің қyzmet zhadayyna baқylau jasau. Zhұқpaly mononucleosis ә mkazi wa lymphocytic leukemia bar, ampicillin қabyldaғan emdelushіlerdің kөbіsіnde erythematosis bөrtpenің payda bolғany bajaldy, ampicillin tobyna antioticterin mіndai emdelush Mankhwala ndi potaziyamu kapamwamba.

Sodium Mölsheri Schektelgen zakudya saқtausha edelushіler әrbіr 600 mg (500 mg + 100 mg) әrbіr құtyda 29.7 mg sodium, 1.2 g (1000 mg + 200 mg) әрбір құтыда 59.3 mg wa sodium bar ekendigin eskergen zh. Ezhoүary kүdeldektі dosad sodium mөlcheri 200 mg-nan asad. Sodium amoxicillin amuna potaziyamu clavulanatyn zochotseka zotupa ғoldanғan kedeезде Benedict reagent nemese Kulemba erindіndіsіn ездеoldanғan kede нес nonseptegly glucose

Disulfirammen bіr mezgіlde taғayyndamaғan azimayi.

Mankhwala zhktіlіk kesіnde tek tolyқ kөrsetіlіmder bolғan kездеeғa tanaayndaluy yыtimal. Sodium amoxicillin ә zhne clavulan қyshylı azdagan mөlsherde emшek sүtіmen bіrge bөlіnіp manyaziғady. Emdelu kezinda mpira emіzudі toқtata tұrғan akazi.

Mlingo ndi njira yoyendetsera

Ana a zaka 3 mpaka 12 zaka - pa mlingo wa 25/5 mg / kg thupi (malinga ndi sodium amoxicillin komanso potaziyamu clavulanate) nthawi yayitali maora 8, matenda akayakaya, pakadutsa maola 6

Ana osakwana miyezi 3.: asanakwane komanso munthawi ya perinatal - pamiyeso ya 25/5 mg / kg kulemera kwa thupi (malinga ndi zonse Amoxicillin sodium ndi potaziyamu clavulanate) maola 12 aliwonse, panthawi yobereka - pa mlingo wa 25/5 mg / kg wa thupi (malinga ndi Sodium amoxicillin ndi potaziyamu clavulanate aliyense maola 8

Mlingo wa prophylactic wochizira maopaleshoni ndi 1.2 g popanga mankhwala ochita opaleshoni (wokhala ndi nthawi yopanga opaleshoni yochepera maola 2), ndi maopareshoni a nthawi yayitali - 1.2 g mpaka 4 nthawi / tsiku.

Kwa odwala omwe ali ndi vuto la impso, muyezo komanso / kapena pakati pa Mlingo wa mankhwala uyenera kusinthidwa malinga ndi chilolezo cha creatinine (onani tebulo).

Popeza 85% Amoxicillin sodium ndi potaziyamu clavulanate amachotsedwa ndi hemodialysis, mankhwalawa amatumizidwa kumapeto kwa ndondomeko ya hemodialysis. Ndi peritoneal dialysis, kusintha kwa mankhwalawa sikofunikira.

Njira ya mankhwala ndi masiku 5-14. Kutalika kwa maphunzirowa kumatsimikiziridwa payekhapayekha ndipo sikuyenera kupitirira masiku 14. Ndi kuchepa kwa zizindikiro, kusinthika kwa mitundu yamkamwa ndikulimbikitsidwa kuti mupitilize chithandizo.

Malangizo okonza ndi kutsata njira za jakisoni wa iv
Zomwe zili mu vial ya 600 mg (500 mg + 100 mg) ziyenera kusungunuka mu 10 ml ya madzi a jakisoni kapena 1.2 g (1000 mg + 200 mg) mu 20 ml ya madzi a jakisoni. Mu / kulowa kulowa pang'onopang'ono (mkati mwa mphindi 3-4.)

Malangizo pokonza ndi kutsata njira yothetsera kulowetsedwa kwa mtsempha
Pa kulowetsedwa makonzedwe, kuwonjezeredwa kwina kwa mankhwalawa ndikofunikira: mayankho okonzekera omwe ali ndi 600 mg (500 mg + 100 mg) kapena 1.2 g (1000 mg + 200 mg) ya mankhwalawa amayenera kuchepetsedwa mu 50 ml kapena 100 ml ya kulowetsedwa. Kutalika kwa kulowetsedwa ndi mphindi 30 mpaka 40. Mukamagwiritsa ntchito njira zotsatirazi zamkati muzoyenerera, maantibayotiki ofunikira amasungidwa mwa iwo.

Njira zotsatirazi za kulowetsedwa zingagwiritsidwe ntchito ngati zosungunulira za infusions.

Eresecterge zhene 12 jastan Askan nemese de salmaғ 40 kg-nan astam bolatyn balalarғa kukonzekera 1.2 g (1000 mg + 200 mg) ya mankhwala 8 saғat arylyқpen, zhpa barysy ayyr bolkan jaidaida 6 saғat aralıpen cholembera tayayndaydy.

3 aiylқtan 12 jasқa deyingі balalarғa - әр kg dene salmagyna shaganda 25/5 mg wa mlingo (barly қ sodium amoxicillin men potaziyamu clavulanatyna shaganda) 8 saғat aralıpen, zhpa barysy auyr bolғan jaidaida 6 saғat arylyқpen taayyndaydy.

3 iiққa deiіngі balalarғa: shala tuғan balalarғa ә zhine perinataldy kesңde - әр kg dené salmagyna shaққanda 25/5 mg mg (barleyқ sodium amoxicillin men potaziyamu clavulanatina sha) anda) әrbіr 12 saғat sayin dozenokelina kenyena kaleina 5 - amuna potaziyamu clavulanatyna shaққanda) әrbіr 8 saғat saiyn.

Opaleshoni қ aralasymdarda aldyn alu angapoasy іengіzіletіn narcotic mankhwala 1.2 g құanthas (opaleshoni ұұққғғ 2 2 saғattan kem bғғanda), opaleshoni ұұққғғөөөіііііғғғғ - - 4 4 рет дей рет 1.2 1.2 1.2 1.2 1.2-nan.

85% sodium amoxicillin, potaziyamu clavulanate, hemodialysis, agyly zhoyylatyndytan, kukonzekera kwa hemodialysis, ayқtalғannan keyin enziedі. Peritonealdi dialysis dosalau tәrtіbіn tүzetu emez. Emdela maphunziro 5-14 kүndі құraydy. Emdela kursnyұ ұзқтығы әр Adamғa zhekely anyқtalady zhne 14 knnen aspauғa tiis. Sy Symbomdardsң auyrlyқ dәrezhesі azayғan kezhe emdeudі zhalғastyru үshіn mankhwala ңshіletіn tүrіne kөshu kerek.

Injectтының ішіндегі 600 mg zatta (500 mg + 100 mg) jakisoni ғ arnalғan 10 ml kwa mwezi 1.2 g zatty (1000 mg + 200 mg) jakisoni ғ arnalғan 20 ml suғa eritken zhen. K / i Bayau Engizu Kerek (3-4 min. Nkhondo)

Zochita Zamankhwala

Pogwiritsa ntchito munthawi yomweyo Amoxicillin sodium ndi potaziyamu clavulanate ndi anticoagulants osadziwika, kuwonjezereka kwa nthawi ya prothrombin kumadziwika. Chifukwa chake, kuphatikiza uku kumayikidwa mosamala.

Pogwiritsa ntchito munthawi yomweyo Amoxicillin sodium ndi potaziyamu clavulanate ndi allopurinol, chiopsezo chotenga zotsatira zoyipa monga kuchuluka kwa exanthema kumawonjezereka.

Ndi munthawi yomweyo kugwiritsa ntchito sodium amoxicillin ndi potaziyamu clavulanate, diuretics, allopurinol, phenylbutazone, NSAIDs ndi mankhwala ena omwe amatseka kubisalira kwa tubular kumawonjezera ndende ya amoxicillin (clavulanic acid imachotsedwa makamaka ndi kusefera kwa glomerular).

Maantibayotiki amathandizira kuchepetsa kupatsirana kwa pakamwa.

Kuchita zamankhwala

Amoxicillin sodium ndi potaziyamu clavulanate ndi aminoglycoside maantiana mwakuthupi komanso mwanjira zina sizigwirizana.

Pewani kusakanikirana ndi mankhwalawa ndi mayankho a dextrose (glucose), dextran, bicarbonate (chifukwa mankhwalawo sakhazikika) komanso komanso ndi mayankho okhala ndi magazi, mapuloteni ndi lipids.

Amoxicillin sodium ndi potaziyamu clavulanate siziphatikizidwa mu syringe yomweyo kapena kulowetsedwa vial ndi mankhwala ena.

Sodium amoxicillin amuna potaziyamu clavulanathine әseri tikely emes antagagant mankhwala bir mezgilde taayyndaғ ke prothrombin uazytynyң artңany bilіnedi. Sondyқtan mavu ndiyyntyty taғayyndaғanda saқ bolu krek.

Sodium amoxicillin amuna potaziyamu clavulanatyn allopurinolmen bir mezgilde ғoldanғan kezhe exantheum shiқyta zhaсыymsyz әserlerdің damu қaupі artada.

Sodium amoxicillin amuna potaziyamu clavulanatine diuretictermen, allopurinolmen, phenylbutazonmen, ҚҚSD ә ө zekshelіk secretion bөgateіn basқaday dәrіlіk тарtarmen bіr mezgılžo

Antibiotic ishіletіn kuletsa kulera tіmdіlіgіn tendmendadeted.

Mankhwala қ разара әрекеттесуі

Sodium amoxicillin amuna potaziyamu clavulanates ә aminoglycosidic antioxotic physical қ mankhwala ғ tұrғydan үylespeydi.

Pharmacokinetics

Magawo akuluakulu a pharmacokinetic a amoxicillin ndi clavulanic acid ndi ofanana. Amoxicillin ndi clavulanic acid osakanikirana sakukhudzana.

Kugawa
Pazitali kwambiri pambuyo pobayira wa Amoxicillin sodium ndi potaziyamu clavulanate 1.2 g ndi 105.4 mg / L kwa amoxicillin ndi 28,5 mg / L wa clavulanic acid. Zonsezi zimadziwika ndi kuchuluka kogawika m'madzi amthupi ndi minyewa (mapapu, khutu lapakati, zotuluka ndi zotumphukira za m'mimba, chiberekero, mazira). Amoxicillin imalowanso madzi ophatikizika a chiwindi, chiwindi, matumbo a prostate, minofu ya palatine, minofu ya minyewa, chikhodzodzo, kutsekeka kwa mphuno, malovu, kubisala kwa bronchial.

Amoxicillin ndi clavulanic acid samadutsa chotchinga magazi mu maukonde osavulala.

Kuzindikira kwakukulu kwamadzimadzi amthupi kumawonedwa ola limodzi pambuyo pofika pazambiri za plasma.

Zinthu zodutsa zimadutsa chotchinga ndipo poyang'ana mozama zimafukusidwa mkaka wa m'mawere. Kumangiriza kwa mapuloteni a plasma a amoxicillin ndi 17-20%, a clavulanic acid - 22-30%.

Kupenda
Amoxicillin amaphatikizidwa pang'ono, Clavulanic acid imapangidwa mwachangu m'chiwindi ndipo amachotseredwa ndi kusefera pang'ono, pang'ono pang'ono ngati ma metabolites.

Kuswana
Amoxicillin amachotseredwa makamaka ndi impso ndi tubular secretion ndi glomerular kusefera. Clavulanic acid imapukusidwa ndi kusefera kwa glomerular, mwanjira ina ya metabolites. Zing'onozing'ono zimatha kupukusidwa kudzera m'matumbo ndi m'mapapu. T1 / 2 ya amoxicillin ndi clavulanic acid ndi maola 1-1.5. Zinthu zonsezi zimachotsedwa ndi hemodialysis komanso zazing'ono mwa peritoneal dialysis.

Amoxicillin amuna clavulan қyshylynyң negіzgі pharmacokinetic қ parametlerі ассас. Amoxicillin әne clavulan қyshyly zhyyntyta bir-bіrіne yқpalyn tigizbeydі.

Amoxicillin sodium sodium potaziyamu codiumulanate amuna opweteka jekeseni keyin ezhoғary ndende ya 105.4 mg / l amoxicillin mkazi 28,5 mg / l clavulan қyshylynda 1,2 g rydydy. Gawo la eci ndi loti thupi laanthu olimba sұyyқtyқtarynda (өkpe, ororta құlaқұ, pleurals, ndi peritonealdy sұyyқtyқta, zhatyrda, anabezda) zaқsa taraluymen sipattalady. Amoxicillin Sogndal-AK sinovialdy sұyyқtyққa, bauyrғa, қuyқasty bezіne, taңday Badamsha bezderіne, bұlshyқet tіnderіne, өt қaltasyna, mұrynnyң osalқy қuystarynyң skretterіne, sіlekeyge, bronchus sekretіne өtedі. Amoxicillin amuna clavulan қyshyly қabynbaғan mi қaby қ tarynda hematoencephalalyқ bөget arқyly пtpeydi.

Zamoyo sұyytytytarynda ezhoғary ndende қan plasmazynda ejoғary concentration ғ zhetkennen keyin 1 saғattan soң bajalada. Belsendі zattar placentala bugi argyly өtedі zhne bolar-bolmas ndende unyolo emshek sүtіmen bөlіnіp manyaziғady. Idsan plasmas қuyzdarymen bailanysuy amoxicillinde 17-20%, clavulan қyshylynda 22-30% құ zigawenga.

Kupenda
Amoxicillin ishinara kagayidwe. Clavulan қyshylı bauyrda belsendі tүrde metabolizdenedі zhne noiseқtyқ sүzіlu arқyly, іshіnara metabolite tүrіnde shygarylad.

Shygaryluy
Amoxicillin negіzіnen bүyrekterde өzekshelіk kubisalira әәne noiseқtyқ sүzіlu arқyly shygarylad. Clavulan қyshyly noisyқtyқ sүzіlu arқyly, іshіnara metabolite tүrіnde shyғarylady Azdaғan mөlsherі ішек және өкпелер ақылы шығарылыы мүмкін. Amoxicillinnus clavulan қyshylynyң T1 / 2 1-1.5 saғatta құanthas. Gawo la eci ndi hemodialysis wa agyly jane azdaғan molsherde peritonealdi dialysis agyly joyylad.

Mankhwala

Anti-wodziwika wa antiotic, ili ndi semisynt syntic penicillin amooticillin ndi β-lactamase inhibitor clavulanic acid. Clavulanic acid imapanga khola losakhazikika bwino ndi β-lactamases ndikuwonetsetsa kukana kwa amoxicillin pazotsatira zawo. Clavulanic acid, yofanana ndi mankhwala a β-lactam, ali ndi ntchito yofooka ya antibacterial. Sodium Amoxicillin amasokoneza kapangidwe ka khungu la bakiteriya.

Amoxicillin sodium ndi potaziyamu clavulanate amachita bactericidal pamitundu yambiri yama gram-positive and gram-negative bacteria (kuphatikizapo zovuta zomwe zakhala zikulimbana ndi mankhwala ophera beta-lactam chifukwa chopanga β-lactamases).

Amoxicillin sodium ndi potaziyamu clavulanate amagwira motsutsana

aerobic gram zabwino mabakiteriya: Streptococcus spp. (kuphatikiza Streptococcus pneumoniae, Streptococcus viridans, Streptococcus milleri, Streptococcus pyogene, Streptococcus bovis), Enterococcus spp., Staphylococcus aureus (kupatula mitsempha yoletsa methicillin), Staphylococcus epidermidis. Listeria spp., Nocardia asteroides,

aerobic gram-negative bacteria: Bordetella Pertussis, Brucella spp. , Proteus vulgaris, Providencia spp., Salmonella spp., Shigella spp., Vibrio cholerae, Yersinia enterocolitica, Eikenella corrodens,

mabakiteriya a anaerobic: Actinomyces israelii, Bacteroides spp. (kuphatikiza Bacteroides fragilis), Prevotella melaninogenica, Clostridium spp. (kupatula Clostridium Hardile), Peptostreptococcus spp., Fusobacterium spp., Propionibacterium spp.

Sodium amoxicillin, potaziyamu clavulanates, magalamu, magalamu a bakiteriya, auқymdy өrіsіne (onyңndі β-lactamase інімінің жасалаы Saldarynan beta-lactamides beta-lactamides antiotic steric acid bacteria.

Sodium amoxicillin ә zhne potaziyamu clavulanates myna aerobts gramң bakiteriya ғ belsendі: Streptococcus spp. (onshinde Streptococcus pneumoniae, Streptococcus viridans, Streptococcus milleri, Streptococcus pyogenes, Streptococcus bovis), Enterococcus spp, Staphylococcus aureus (methicillin-bacillus arnidae), , Nocardia asteroides,

aerobts gramteris bakiteriya: Bordetella Pertussis, Brucella spp. , Proteus vulgaris, Providencia spp., Salmonella spp., Shigella spp., Vibrio cholerae, Yersinia enterocolitica, Eikenella corrodens,

mabakiteriya a anaerobes: Actinomyces israelii, Bacteroides spp. (Onyң Ishind Bacteroides fragilis), Prevotella melaninogenica, Clostridium spp. (Clostridium Hardile-den basқa), Peptostreptococcus spp., Fusobacterium spp., Propionibacterium spp.

Kutulutsa Mafomu

Amoxicillin amapezeka m'mitundu iyi:
1. Makapisozi a 250 mg (16 zidutswa pa paketi iliyonse).
2. 500 mg makapisozi (zidutswa 16 pa paketi iliyonse).
3. Ma granules mu botolo (pokonzekera kuyimitsidwa).

Mitundu yonse ya amoxicillin amatengedwa pakamwa, kuyambitsa kwa maantibayotiki ngati jakisoni (jakisoni) sikunaperekedwe.

Chithandizo cha Amoxicillin

Mlingo wa Amoxicillin
Mlingo wamba wa amoxicillin wa akulu ndi ana opitilira zaka 12 (wokhala ndi thupi loposa 40 kg) ndi 500 mg katatu pa tsiku. Koma m'malo onsewo, mlingo umatsimikiziridwa ndi adokotala, ndipo ngati pangafunike (ngati mukudwala kwambiri) mutha kuwonjezeka mpaka 750-1000 mg katatu pa tsiku, komanso zochulukirapo. Mlingo woyenera wovomerezeka tsiku lililonse kwa akulu ndi 6 g.

Kwa matenda ena, muyezo womwe siwomwe muyezo wa amoxicillin umagwiritsidwa ntchito. Mwachitsanzo, mu chinzonono chachikulu, amuna amapatsidwa mankhwala kamodzi ga 3 ga kwa akazi, omwewo ndi omwe amaperekedwa. Ndi typhoid fever, amoxicillin amagwiritsidwa ntchito muyezo waukulu: 1.5-2 g katatu patsiku. Ndi leptospirosis, mlingo waukulu wa mankhwalawa umagwiritsidwanso ntchito: 500-750 mg 4 pa tsiku.

Pambuyo pakutha kwa zizindikiro zakunja kwa matenda aliwonse, chithandizo chokhala ndi amoxicillin chimatha masiku ena atatu, pofuna kupewa kubwereranso kumatenda. Nthawi zambiri njira yochizira imachokera masiku 5 mpaka 12.

Mlingo wa Amoxicillin wa ana

Amoxicillin, monga mankhwala ena aliwonse, ayenera kuperekedwa kwa ana ndi adokotala okha. Amanenanso kuchuluka kwa mankhwalawa, kutengera zaka komanso kulemera kwa mwanayo, komanso kuopsa kwa matendawa.

Mlingo wambiri wa amoxicillin wa ana ndi awa:
1. Ana osakwana zaka 2 - 20 mg / kg thupi / tsiku. Mlingo wa magawo atatu.
2. Ana a zaka 2-5 - 125 mg (i.e. 1/2 scoop ya kuyimitsidwa) katatu patsiku.
3. Ana a zaka 5 mpaka 10 - 250 mg (1 scoop of kuyimitsidwa) katatu patsiku.

Dokotala amamuwonetsa amoxicillin payekhapayekha, mulingo wochepa, komanso nthawi yayitali pakati pa mankhwala a ana akhanda komanso asanabadwe.

Amoxicillin pa mimba

Kwa azimayi omwe ali ndi pakati, amoxicillin amalembedwa pokhapokha ngati phindu la mankhwalawa kwa mayi limaposa mwayi wovulaza mwana wosabadwayo. Ngakhale sipanakhalepo ndi zifukwa zoyipa za amoxicillin pa mimba ndi kubala, palibe maphunziro oyenerera pamutuwu. Chifukwa chake, madotolo samakonda kutenga ngozi.

Ndipo poyamwitsa, amisililin ya mayi imapangidwa: imadutsa mkaka wa m'mawere ndipo imapangitsa khanda kusokonezeka kapena kusokonezeka m'matumbo am'mimba.

Amoxicillin ndi angina

Ndi purulent mitundu ya angina (follicular ndi lacunar), amoxicillin nthawi zambiri amatchulidwa ngati mankhwala othandiza ndi ochepa mavuto. Kugwiritsa ntchito kwa amoxicillin mu angina kumachitika chifukwa chakuti matendawa nthawi zambiri amayamba chifukwa cha staphylococcus, kachilombo kakang'ono kamene kamayang'anira zovuta za antibayotikiyu.

Ngakhale ndi matenda ena, amoxicillin amaperekedwa kwa wodwala mosasamala kanthu za kudya, ndi angina, mankhwalawa amayenera kumwedwa atatha kudya kuti athetse mphamvu yake patoni yovunda.
Zambiri pa zilonda zapakhosi

Amoxicillin + clavulanic acid (Amoxiclav)

Pali mankhwala ngati omwe amoxicillin amaphatikizidwa ndi clavulanic acid. Mankhwala amatchedwa amoxicillin clavulanate , kapena Amoxiclav , kapena Augmentin . Tikukumbukira kuti amoxicillin m'thupi la munthu simalimbana mokwanira chifukwa cha penicillinase enzyme. Clavulanic acid imatha kuletsa enzyme iyi, kuti amoxicillin isagonje ndikuchita mabakiteriya oyipa kwa nthawi yayitali. Amoxiclav amadziwika kuti ndi mankhwala amphamvu kwambiri kuposa amoxicillin.
Zisonyezero zogwiritsira ntchito Amoxiclav:

Bakiteriya matenda am'munsi kupuma thirakiti (chibayo, bronchitis, m'mapapo, zotupa.
Zofooka khutu, mmero ndi mphuno (otitis media, tonsillitis, tonsillitis, sinusitis, kutsogolo sinusitis).
Matenda a kwamikodzo ndi ziwalo zoberekera (pyelonephritis, pyelitis, prostatitis, salpingitis, ovarian abscess, endometritis, postpartum sepsis, septic mimba, gonorrhea, chancre chancre, etc.
Matenda a pakhungu ndi minofu yofewa (abscess, phlegmon, erysipelas, mabala omwe ali ndi kachilombo).
Osteomyelitis
Matenda a postoperative ndi kupewa kwawo.

Mitundu ya kumasulidwa kwa Amoxiclav:
1. Mapiritsi a 375 mg ndi 625 mg (zomwe zili amoxicillin akuwonetsedwa mg).
2. Ufa wa kuyimitsidwa ndi ndende ya 156 mg / 5 ml ndi 312 mg / 5 ml.
3. Ufa wa inhalation 600 mg pakiti iliyonse, ndi 1.2 g pa paketi iliyonse.

Mlingo wa Amoxiclav Amawerengeredwa mogwirizana ndi amoxicillin, chifukwa ndi maantibayotiki omwe ndi mankhwala othandizira.
Zambiri za Amoxiclav

Pafupifupi ndemanga zonse zomwe zimapezeka pa intaneti zokhudzana ndi antioxidicin yoletsa. Odwala amawona kuthamanga kwa mankhwalawa, kugwiritsa ntchito mosavuta (phwando silimadalira nthawi yakudya), kuchira kwathunthu kumatenda omwe ali kumapeto kumapeto kwa chithandizo.

Chiwerengero chochepa cha ndemanga zoyipa zomwe odwala amadandaula kuti mankhwalawa "sanathandizidwe" chifukwa chakuti amoxicillin, ngakhale ndi mankhwala opha tizilombo, alibe mphamvu zonse, ndipo si mabakiteriya onse amene amamvera mayendedwe ake. Chifukwa chake, tikulimbikitsidwa kuyezetsa odwala musanapange mankhwala awa: pezani mankhwala a causative wothandizira ndikuwonetsetsa momwe mankhwalawo akumvera. Koma maphunziro awa amafunikira nthawi yayitali, ndipo nthawi zambiri amachitika mochitika. Mwakuchita izi, adotolo, poyesera kuchepetsa mkhalidwe wa wodwalayo, amapereka mankhwala popanda kumuwunika, mwanjira inayake mwadzidzidzi, ndipo nthawi zina amalakwitsa. Odwala amaganiza kuti kuchepa kwa mankhwalawa kusowa kwa mankhwala - lingaliro ili silolondola.

Antioxotic Amoxicillin

Mankhwala amagwiritsidwa ntchito ngati njira ya antibacterial mankhwala. Amoxicillin ndi wa maanti-virus wodziwika bwino, ndi gawo la gulu la semisynthetic penicillins. Mankhwalawa ndi analogue a ampicillin, koma atamwa pakamwa, amadziwika ndi bioavailability wabwino. Malinga ndi malangizo ogwiritsira ntchito, mankhwalawa ali ndi mphamvu ya antibacterial pokhudzana ndi:

aerobic gram zabwino mabakiteriya - Staphylococcus spp., Streptococcus spp.,
gram alibe–Salmonella spp., Neisseria meningit>

Malinga ndi malangizo, Amoxicillin ali ndi chinthu chachikulu chogwiritsa ntchito - amoxicillin trihydrate, yomwe ili mu mlingo wofanana ndi mawonekedwe a kumasulidwa. Zothandizira zothandizira zimapatsa mapiritsi ena owonjezera, mawonekedwe odziwika, amawonjezera alumali. Zomwe zimapangidwira, kuwonjezera pa mawonekedwe a madzi am'madzi, zimaphatikizapo:

calcium owawa
lactose monohydrate,
magnesium wakuba,
polysorbate,
talcum ufa
wowuma mbatata.

Mlingo ndi makonzedwe

Momwe mungagwiritsire amoxicillin? Malangizowa akutsimikiza kuti mankhwalawa agwiritsidwe ntchito mkati, osambitsidwa ndi madzi, osagwirizana ndi chakudya. Mlingo wa Amoxicillin zimatengera zaka komanso matendawo. Ndikofunikira kuganizira:

Mlingo umodzi wa akulu, ana opitirira zaka 12 - 250, 500 mg,
woopsa matenda - mpaka gramu 1,
pakati Mlingo, imeneyi ndi maola 8,
Njira zamankhwala ndi kuyambira masiku 5 mpaka 14,
Odwala ndi mkhutu aimpso ntchito, imeneyi amakhazikitsa payekhapayekha,
Mlingo ndi nthawi yayitali ya mankhwala ndi dokotala.

Pa mimba ndi mkaka wa m`mawere

Malangizo amaletsa kugwiritsa ntchito amoxicillin mukamayamwitsa. Mankhwala opha tizilombo akangolowa mkaka, amatha kuvulaza mwana. Ngati chithandizo chikufunika, kudyetsa kuyenera kuyimitsidwa. Kugwiritsa ntchito mankhwalawa panthawi yapakati kumakhala ndi mawonekedwe ake. Penicillins amadutsa pamtunda ndipo amadzisonkhanitsa. Kuchuluka kwa amoxicillin mu amniotic madzimadzi kufika 25-30 peresenti ya plasma ya amayi apakati, yomwe imakhala pachiwopsezo cha kukula kwa fetal.

Pali malingaliro angapo ogwiritsira ntchito maantibayotiki pa nthawi yapakati:

gwiritsani ntchito mankhwalawa pokhapokha akuwonetsa
Dokotala amadziwitsa mtundu wake wa mankhwalawo komanso machitidwe ake poganizira momwe mkazi aliri,
mankhwalawa amaloledwa pokhapokha wachiwiri ndi wachitatu, pamene placenta ipangidwe.
kuyang'anira kwa wodwala kumafunikira
ndikofunikira kuganizira zotsutsana zonse kuti mugwiritse ntchito.

Amoxicillin wa ana

Kutentha kwambiri, kufooketsa thupi ndi matenda - chifukwa chopangira mwana mankhwala. Amoxicillin chifukwa cha chimfine amapatsidwa kwa ana mu mawonekedwe a kuyimitsidwa (onani chithunzi pansipa). Mankhwalawa amakonzekera musanagwiritse ntchito. Kuphatikizidwa ndi supuni yoyezera yomwe ili ndi 250 mg yogwira ntchito. Malangizowo amatsimikizira:

onjezerani madzi m'botolo ndi granules,
sansani osakaniza
Ana ochepera zaka ziwiri amapereka 20 mg wa mankhwala pa kilogalamu ya thupi patsiku,
wazaka ziwiri mpaka zisanu - mlingo ndi 125 mg,
kuyambira zaka 5 mpaka 10 - manambala awirikiza,
opitirira khumi - kuyimitsidwa kwa mlingo mpaka 500 mg,
woopsa milandu - mpaka 1 gramu.

Zochita Zamankhwala

Pogwiritsa ntchito antibacterial wothandizila Amoxicillin, muyenera kuganizira mofanananso zamankhwala ena munthawi yomweyo. Malinga ndi malangizo, kuyanjana ndi mankhwala kumatha kupereka zotsatira zosiyanasiyana. Zotsatira:

Amoxicillin imathandizira mayamwidwe a digoxin,
zimawonjezera zotsatira za anticoagulants,
amachepetsa prothrombin index,
amachepetsa mphamvu za njira zakulera za estrogen,
amachulukitsa kuopsa kwa methotrexate,
amachepetsa kapangidwe ka vitamini K.

Iyenera kukumbukiridwa - Amoxicillin ali ndi vuto la bactericidal pakufalitsa tizilombo, chifukwa chake, sayenera kugwiritsidwa ntchito molumikizana ndi mankhwala a bacteriostatic antimicrobial - sulfonamides, tetracyclines. Ndi munthawi yomweyo:

Glucosamine, mankhwala osokoneza bongo, achepetsa kuyamwa kwa Amoxicillin, ndi ascorbic acid ukuwonjezeka,
Rifampicinkuthamangitsa antibacterial katundu,
Mankhwala osapweteka a antiidal angakulitse kuchuluka kwa maantibayotiki.
Allopurinolkumawonjezera chiopsezo cha zotupa pakhungu.

Kuyamwa kwa mowa

Malinga ndi malangizo, mapiritsi a Amoxicillin, makapisozi kapena kuyimitsidwa sikuyenera kugwiritsidwa ntchito ndi mowa. Kugwiritsa ntchito munthawi yomweyo kumayambitsa kusokonezeka - kusagwirizana mwachindunji, komwe ndi kowopsa kwa thupi, kumakulitsa chiopsezo chaimpso ntchito. Mfundo zotsatirazi ziyenera kulingaliridwa:

Mankhwala othandizira m'magazi amatha mpaka sabata,
mowa umachotsedwa m'thupi pakatha masiku awiri,
Sikuti kugwiritsa ntchito nthawi imodzi ndi koopsa,
ndikofunikira kuganizira nthawi yothetsa mabakiteriya ndi mowa.

Amoxicillin - mavuto

Pogwiritsa ntchito pawokha, kuphwanya Mlingo, osadalira nthawi yayitali, mavuto amabwera. Malangizowo akuwonetsa momwe zimachitika kuti thupi lipezeke ndi Amoxicillin. Zotsatira zoyipa zimawonedwa:

kusowa kwa chakudya
kuphwanya matumbo microflora,
chifuwa
kusowa tulo
kuyabwa
chizungulire
urticaria
kupweteka m'mimba
kutsegula m'mimba
nseru
zotupa za erythematous
kusanza
chiwindi ntchito,
nkhawa
kukokana
conjunctivitis
chikumbumtima
kupweteka kwa molumikizana.

Zotsatira zoyipa zimawonedwa ngati pali mankhwala osokoneza bongo. Kupezeka kwa:

anaphylactic shock,
hemolytic anemia,
matumbo a vasculitis,
Hyperemia,
candidiasis
malungo
cholestatic jaundice,
dysbiosis,
rhinitis
stomatitis
kupuma movutikira
tachycardia,
Edincke's edema,
Kukhumudwa
eosinophilia
zotumphukira neuropathies,
chiwindi
kukomoka.

Mankhwala a Amoxicillin ali ndi zotsutsana kuti agwiritse ntchito, adokotala angasankhe mankhwala ena kuti wodwala athane ndi matenda. M'malo amafunikira komanso ngati zotsatira zoyipa zimachitika, mankhwala akasiya, mankhwala atsopano amapatsidwa. Malangizowo amathandizira kuti pali zoyerekeza za Amoxicillin pazogwira ntchito:

Mochulukitsa
Flemoxin Solutab,
Taromentin
Rapiclav
Samalirani
Clamosar
Baktoklav,
Augmentin
Arlet
Amovikomb,
Ranklav,
Panklav,
Lyclav,
Verklav.

Mtengo wa Amoxicillin

Mankhwala othana ndi antibacterial angagulidwe ku pharmacy yapafupi kapena kuyitanidwa kudzera pa malo ogulitsira pa intaneti. Pankhaniyi, mankhwalawa amayenera kutumizidwa ndi dokotala. Kodi amoxicillin ndi zingati? Mtengo wake umatengera mtundu wa kumasulidwa, mlingo, ndalama zoyendera. Mtengo wapakati wa mankhwalawa ndi ma analogu mu ruble ndi:

Zowonetsa kugwiritsa ntchito Amoxicillin

Malinga ndi malangizo, Amoxicillin imathandizira kupewa tizilombo toyambitsa matenda omwe amayambitsa matenda otsatirawa:

Bronchitis, chibayo,
Pharyngitis, sinusitis, pachimake otitis media, tonsillitis,
Cystitis, pyelitis, urethritis, pyelonephritis, endometritis, gonorrhea, cervicitis,
Cholecystitis, cholangitis, peritonitis,
Impetigo, erysipelas, ma dermatoses opatsirana pambuyo pake,
Matenda a Lyme
Listeriosis, leptospirosis,
Salmonellosis
Kamwazi
Meningitis
Sepsis
Endocarditis (kupewa).

Zotsatira zoyipa za Amoxicillin

Pogwiritsa ntchito Amoxicillin, zotsatirazi zotsatirazi ndizotheka:

Kuchokera mmimba thirakiti: nseru ndi kusanza, kusintha kwa kukoma, dysbiosis, stomatitis, glossitis, kutsegula m'mimba, pseudomembranous enterocolitis, chiwindi ntchito.
Kuchokera kumbali yamanjenje: ataxia, kupsinjika, chisokonezo, nkhawa, kukwiya, kusowa tulo, kusintha kwa chizolowezi, chizungulire, kupweteka mutu, zotumphukira neuropathy, kupweteka,
Thupi lawo siligwirizana: erythema, urticaria, kutupa kwa khungu, rhinitis, conjunctivitis, angioedema, kawirikawiri - kupweteka kwapawiri, kutentha thupi, dermatitis, matenda a Stevens-Johnson, kawirikawiri - anaphylactic shock,
Zotsatira zasayansi: anemia, neutropenia, leukopenia, thrombocytopenic purpura,
Zochitika zina zoyipa: tachycardia, kupuma movutikira, vagidi candidiasis, ma nephritis apakati, kupatsirana kwakukulu (makamaka mwa anthu omwe ali ndi kuchepa kapena matenda osakhazikika).

Zizindikiro za mankhwala osokoneza bongo a Amoxicillin ndi mseru, kusanza ndi kutsekula m'mimba, zomwe zimayambitsa kuphwanya kwamkaka wamadzi. Kuchiza kumakhala ndi kutsuka m'mimba, kupereka mankhwala opangira saline komanso kuyambitsa kaboni, ndikuwongolera bwino bwino kwa-electrolyte.

Amoxicillin analogues

The fanizo la mankhwala, kukhala ndi amoxicillin monga ntchito yogwiritsira ntchito, ndi awa:

Amoxillate (Germany),
Amosin (Russia),
Apo-Amoxy (Canada),
Amoksisar (Russia),
Gonoform (Austria),
Bactox (France),
Grunamox (Germany),
Taisil (Bangladesh),
Ospamox (Austria),
Danemox (India),
Hikontsil (Slovenia),
Ecobol (Russia),
Flemoxin Solutab (Netherlands),
E-Mox (Egypt).

Migwirizano ndi magwiritsidwe akusungidwa

Amoxicillin, malinga ndi malangizo, iyenera kusungidwa m'chipinda chofunda pamalo owuma komanso amdima osawonekera kwa ana.

Kuyimitsidwa okonzekeraku kumasungidwa kwa masiku 14 pa kutentha kwa 15-25 ° C.

Alumali moyo wa mankhwalawa ndi zaka 2, pambuyo pake ziyenera kutayidwa.

Kodi mwapeza cholakwika m'mawuwo? Sankhani ndikusindikiza Ctrl + Lowani.

Zotsatira za pharmacological

Amoxicillin ndi mankhwala omwe ali ndi zovuta zingapo. Gulu la Antibiotic - semisynthetic penicillin. Abstract akuwonetsa kuti mankhwalawa ndi analogue ya 4-hydroxyl ampicillin. Amapereka bactericidal zotsatira. Amawonetsa ntchito yolimbana ndi aerobic gram-bacteria wabwino, monga Streptococcus spp., Staphylococcus spp. (kupatula zingwe zomwe zimatulutsa penicillinase). Yogwiranso ntchito motsutsana ndi mabakiteriya osavomerezeka aerobic: Shigella spp., Neisseria gonorrhoeae, Escherichia coli, Nisseria meningitidis, Klebsiella spp., Salmonella spp.

Chowona Zanyama Amoxicillin

Mankhwala azovomerezeka, jakisoni wa 15% amoxicillin amagwiritsidwa ntchito. Kwa nyama, imagwiritsidwa ntchito pochiza matenda obwera chifukwa cha m'mimba, matenda a pakhungu, matenda a kupuma, matenda a genitourinary system, etc. Amagwiritsidwa ntchito ngati agalu, amphaka, ng'ombe. Mankhwalawa amayenera kuperekedwa pakhungu kapena intramuscularly, mulingo wambiri pamenepa ndi 1 ml pa 10 makilogalamu. Ngati ndi kotheka, lembani mankhwalawa pambuyo pa maola 48. Kupsinjika kopepuka kwa malo omwe mankhwalawo adalowetsedwa ndikulimbikitsidwa.

Malangizo a Amoxicillin DS

Muyenera kumwa 500 mg katatu patsiku. Ngati matenda oopsa adziwika, adokotala amatha kuwonjezera mlingo wa 750-1000 mg. Zochitika zamankhwala zimatengera kuzindikira kwa wodwala.

Mlingo wa Amoxicillin wa angina zimatengera kukula kwa njira zomwe zimagwirira ntchito. Monga ulamuliro, ndi angina, mwachizolowezi mlingo wa mankhwala zotchulidwa - 500 mg katatu patsiku. Momwe mungatengere kwa akuluakulu kapena momwe mungatengere ana omwe ali ndi chimfine, muyenera kuonana ndi dokotala.

Mlingo wa sinusitis zimatengera zomwe dokotala wamupatsa. Mlingo wa akuluakulu nthawi zambiri amakhala 500 mg ya mankhwala katatu patsiku, mankhwalawa amakhala pafupifupi sabata limodzi. Komabe, ndendende za kuchuluka kwa mankhwalawa.

Bongo

Monga lamulo, ndi mankhwala osokoneza bongo, palibe chomwe chimatchulidwa poizoni, ngakhale mlingo waukulu wa mankhwalawo utatengedwa. Ngati mlingo waukulu wa Amoxicillin unatengedwa, wodwalayo amawonetsa zizindikiro za kukhumudwa m'mimba, kuphwanya malire a madzi osankhidwa ndi madzi. Mwa anthu omwe ali ndi vuto la impso, mankhwala osokoneza bongo amatha kuonetsa zizindikiro za nephrotoxicity ndi crystalluria.

Chithandizo cha mankhwala chimachitika, chomwe mankhwalawa adagwiritsidwa ntchito ndi adotolo, muyeneranso kumwa kaboni yodziyambitsa. Zitha kugwira ntchito hemodialysis. Palibe mankhwala enieni.

Zomwe zili bwino: Flemoxin Solutab kapena Amoxicillin?

Monga gawo la mankhwala Flemoxin ili ndi chinthu chofananira. Koma Amoxicillin amagwiritsidwa ntchito nthawi zambiri kuchiza odwala akuluakulu. Flemoxin Solutab amakamizidwa msanga m'mimba, amatha kugwiritsidwa ntchito ndi chakudya, amakhala ndi kukoma kosangalatsa. Mapiritsi awa amatha kusungunuka m'madzi ndikukonzekera kuyimitsidwa kapena madzi. Flemoxin Solutab ndi mankhwala okwera mtengo kwambiri.

Amoxicillin wa ana

Kwa ana, mankhwalawa amagwiritsidwa ntchito mosamalitsa malinga ndi dongosolo lomwe dokotala wakhazikitsa. Monga lamulo, ana adayikidwa kuyimitsidwa, gwiritsani ntchito amoxillin ndipo metronidazole osavomerezeka kwa ana ndi achinyamata ochepera zaka 18. Mlingo wa Amoxicillin wa ana zimatengera kulemera kwa mwana, zaka zake, matenda. Amoxicillin kwa makanda amalembedwa payekhapayekha kwa ana akhanda, amapanga makulidwe akuluakulu pakati Mlingo ndi kutsatira mosamalitsa zomwe adokotala adaziwonetsa.

Amoxicillin ndi mowa

Mu malangizo a mankhwalawa palibe chidziwitso choti mankhwalawo amaphatikizidwa ndi mowa. Komabe, madokotala salimbikitsa kuchita izi. Kupatula apo, mowa umachepetsa mphamvu ya mankhwalawa. Potere, zovuta zimatha kuwonjezeka.Zosayembekezereka pamachitidwe amanjenje zitha kudziwika, zovuta za chiwindi zikuchulukirachulukira, chiwopsezo cha mawonekedwe owoneka kwambiri, zovuta zakupuma zikuchulukirachulukira. Tiyenera kudziwa kuti mapiritsiwa ndi mankhwala osokoneza bongo, omwe amayenera kugwiritsidwa ntchito pokhapokha popewa kumwa mowa.

Ndemanga za Amoxicillin

Pa intaneti, ndemanga za Amoxicillin ndizabwino kwambiri. Amazindikira kuti atayamba chithandizo, momwe amadziwonekera mwachangu kwambiri, mankhwalawa ndi oyenera kugwiritsa ntchito kwa onse akulu ndi ana, omwe kuyimitsidwa kwapadera kwa ana. Komanso, monga zabwino, zimatchulidwa kuti mankhwalawa atha kumwa nawo wa mimba.

Mukamakambirana ndi Amoxicillin, ndemanga za madokotala nazonso zabwino. Koma akatswiri nthawi zonse amalemba kuti kudzichiritsa nokha ndi mankhwalawa ndikosavomerezeka.