Plevilox mankhwala: malangizo ntchito

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Zotsatira za pharmacological

Wothandizira antimicrobial kuchokera pagulu la fluoroquinolones, amachita bactericidal. Imagwira pakulimbana ndi tizilombo tating'onoting'ono tambiri ta gramu-gramu komanso gram-negative, anaerobic, acid osagwira komanso mabacteria atypical: Mycoplasma spp., Chlamydia spp., Legionella spp. Kugwiritsa ntchito polimbana ndi mabakiteriya okhala ndi beta-lactams ndi macrolides. Imagwira pakulimbana ndi tizilombo tosiyanasiyana tambiri tating'onoting'ono: gram-positive - Staphylococcus aureus (kuphatikiza zingwe zomwe sizimvera mwachangu methicillin), Streptococcus pneumoniae (kuphatikiza tizilombo ta penicillin ndi macrolides), Streptococcus pyogene (gulu A), gram-negative - kuphatikizapo hememilus ndi mitundu yopanda-beta-lactamase yopangira), Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis (kuphatikiza mitundu yopanda-beta komanso ya beta-lactamase yopanga), Escherichia coli, Enterobacter cloacae, atypical Chlamydia pneumonia. Malinga ndi kafukufuku wa in vitro, ngakhale tizilombo tating'onoting'ono taikidwa pansipa timazindikira moxifloxacin, komabe, chitetezo chake komanso magwiridwe ake othandizira matenda sizinakhazikitsidwe. zamoyo galamu HIV: Streptococcus milleri, Streptococcus mitior, Streptococcus agalactiae, Streptococcus dysgalactiae, Staphylococcus cohnii, Staphylococcus epidermidis (kuphatikizapo tizilombo ta, methicillin tcheru), Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus saprophyticus, Staphylococcus simulans, Corynebacterium diphtheriae. Zamoyo zopanda gramu: Bordetella pertussis, Klebsiella oxytoca, Enterobacter aerogene, Enterobacter agglomerans, Enterobacter Intermedius, Enterobacter sakazaki, Proteus mirabilis, Proteus vulgaris, Morganella morganii, Providencia rettgeri, Providencia stuartii. Anaerobic tizilombo: Bacteroides distasonis, Bacteroides eggerthii, Bacteroides fragilis, Bacteroides ovatus, Bacteroides thetaiotaornicron, Bacteroides uniformis, Fusobacterium spp, Porphyromonas spp, Porphyromonas anaerobius, Porphyromonas asaccharolyticus, Porphyromonas Magnus, Prevotella spp, Propionibacterium spp, Clostridium perfringens, Clostridium .... ramosum. Tizilombo tating'onoting'ono: Legionella pneumophila, Caxiella burnettii.

Ma blocks topoisomerases II ndi IV, ma enzymes omwe amawongolera zinthu zapamwamba za DNA, ndipo amathandizira kubwereza, kukonza, ndikulemba kwa DNA. Mphamvu ya moxifloxacin zimatengera kukhazikika kwake m'magazi ndi zimakhala. Zozungulira zochepa za bactericidal pafupifupi sizimasiyana ndi zochepa zoletsa.

Kukana njira zopangira, kupangira penicillin, cephalosporins, aminoglycosides, macrolides ndi tetracyclines, sizimakhudzana ndi antibacterial zochita za moxifloxacin. Palibe kukana pakati pa moxifloxacin ndi mankhwalawa. Njira yolimbirana yolimbana ndi plasmid -edi yolankhulirana siinawonedwe. Zowonjezera zonse zakusagwirizana ndizochepa. Kafukufuku wa in vitro awonetsa kuti kukana kwa moxifloxacin kumakula pang'onopang'ono chifukwa cha kusinthana kotsatizana. Kudziwitsidwa pafupipafupi kwa tizilombo tosiyanasiyana tokhala ndi moxifloxacin mozama mozama, zolembera za BMD zimangokulira pang'ono. Kutsutsa kwamtanda kumawonedwa pakati pa mankhwala ochokera ku gulu la fluoroquinolone. Komabe, tizilombo tating'onoting'ono ta gramu-ana ndi anaerobic omwe amalimbana ndi fluoroquinolones ena amamvera moxifloxacin.

Pharmacokinetics

Pambuyo pakukonzekera pakamwa, moxifloxacin imagwira mwachangu komanso pafupifupi kwathunthu. Pambuyo pa limodzi mlingo wa moxifloxacin pa mlingo wa 400 mg C max m'mwazi zimatheka mkati mwa maola 0.5-4 ndipo ndi 3.1 mg / L.

Pambuyo pa kulowetsedwa kamodzi pa mlingo wa 400 mg wa 1 h, C max imafika kumapeto kwa kulowetsedwa ndipo ndi 4.1 mg / l, yomwe ikufanana ndi kuwonjezeka kwa pafupifupi 26% poyerekeza ndi mtengo wa chizindikirocho mukamamwa. Ndi ma infusions angapo a IV pamiyeso ya 400 mg kwa 1 ora, C max imasiyanasiyana pamakina kuyambira 4.1 mg / l mpaka 5.9 mg / l. Avereji ya C ss ya 4.4 mg / L imafika kumapeto kwa kulowetsedwa.

Mtheradi bioavailability pafupifupi 91%.

Pharmacokinetics ya moxifloxacin atamwa limodzi mu 50 mg mpaka 1200 mg, komanso mlingo wa 600 mg / tsiku kwa masiku 10, ndi liniya.

Dera lolingana limafikiridwa pakatha masiku atatu.

Kumangiriza kumapuloteni amwazi (makamaka albin) pafupifupi 45%.

Moxifloxacin imagawiridwa mwachangu mu ziwalo ndi minofu. V d ndi pafupifupi 2 l / kg.

Kuzungulira kwa moxifloxacin, ochulukirapo kwa omwe amapezeka m'madzi a m'magazi, kumapangidwa minofu ya m'mapapo (kuphatikizapo alveolar macrophages), mucous membrane wa bronchi, mu sinuses, mu minofu yofewa, khungu ndi subcutaneous zida, maziko a kutupa. Mu madzi akumwa ndi malovu, mankhwalawa amatsimikiza mawonekedwe omasuka, osakhala ndi mapuloteni, pamsika wambiri kuposa plasma. Kuphatikiza apo, kuchuluka kwazomwe zimagwira ntchito zimatsimikizika mu ziwalo zam'mimba komanso zotumphukira zamkati, komanso mu ziwalo za akazi.

Biotransformed kuti yogwira sodium mankhwala ndi glucuronides. Moxifloxacin saumbidwa ndi microsomal chiwindi michere ya cytochrome P450 system.

Pambuyo popyola gawo lachiwiri la biotransfform, moxifloxacin imachotsedwa m'thupi ndi impso komanso matumbo, osasinthika komanso mawonekedwe osakanikirana a sulfo mankhwala ndi glucuronides.

Amayikamo mkodzo, komanso ndowe, zonse zosasinthika komanso ma metabolites osagwira. Ndi gawo limodzi la 400 mg, pafupifupi 19% imachotsedwa mu mkodzo, pafupifupi 25% yokhala ndi ndowe. T 1/2 ndi pafupifupi maola 12. Nthawi zonse chilolezo chomaliza pambuyo pa chithandizo cha 400 mg chimachokera 179 ml / mphindi mpaka 246 ml / min.

Zizindikiro zogwiritsidwa ntchito

Matenda a kumtunda komanso kwam'munsi kupuma kwamatumbo: matenda opweteka kwambiri, kupweteka kwa chibayo, chibayo, matenda a pakhungu komanso minofu yofewa, kuphatikizira matenda amkatikati mwa m'mimba, kuphatikiza matenda oyambitsidwa ndi tizilombo tating'onoting'ono, matenda opepuka a ziwalo za m'chiuno.

Momwe mungagwiritsire ntchito: Mlingo ndi njira ya chithandizo

Mkati kapena mawonekedwe a kulowetsedwa kwa mtsempha (pang'onopang'ono, kupitilira mphindi 60) - 400 mg 1 nthawi patsiku. Piritsi limamezedwa lonse, osafuna kutafuna, osasamala chakudyacho. Njira ya mankhwala kukokomeza matenda osakhazikika - masiku 5, chibayo - masiku 10, sinusitis pachimake, matenda a pakhungu ndi zimakhala zofowoka - masiku 7, ndi zovuta zamkati matenda am'mimba - mkati mwa masiku 5-14 (iv ndi kusamutsira pakumwa pakamwa) , zovuta zotupa zotupa za m'chiuno - masiku 14.

Sikoyenera kusintha mankhwalawa kwa odwala okalamba omwe ali ndi hepatic (gulu A, B pa Child-Pugh wadogo) ndi / kapena aimpso (kuphatikiza ndi CC zosakwana 30 ml / min / 1.73 sq.m).

Zotsatira zoyipa

Nthawi zambiri - 1-10%, kawirikawiri - 0,1-1%, osowa kwambiri - 0.01-0.1%.

Kuchokera mmimba: kawirikawiri - kupweteka kwam'mimba, kukomoka (kuphatikizapo kusweka, mseru, kusanza, kudzimbidwa, kuchuluka) kwa "chiwindi" transaminases, osowa - mucous nembanemba wamkamwa, pacidiasis pamlomo wamkamwa, anorexia, stomatitis, glossitis, kuchuluka kwa gamma-glutamintransferase, osowa kwambiri - gastritis, kusinthika kwa lilime, dysphagia, jaundice wosakhalitsa.

Kuchokera kumbali yamanjenje: kawirikawiri - chizungulire, kupweteka mutu, kawirikawiri - asthenia, kusowa tulo, kugona, mantha, nkhawa, kunjenjemera, maresthesia, kawirikawiri kwambiri - kuyerekezera zinthu zina, kuyerekezera mtima, kuchuluka kwa minofu, kukhudzika kwamiseche, kusokonekera, minnesia, aphasia, kuvutikira kwakamtima, kusokonezeka kwa tulo, kusokonezeka kwa mawu, kusokonezeka kwa chidwi, Hypesthesia, kukhumudwa, kusokonezeka, kukhumudwa.

Mbali ya ziwalo zam'maganizo: Nthawi zambiri - kusintha kwa kakomedwe, kawirikawiri - kuwonongeka kowonekera, amblyopia, kuchepa kwa chidwi chomva, parosmia.

Kuchokera ku CCC: kawirikawiri - tachycardia, kuthamanga kwa magazi, palpitations, kupweteka pachifuwa, kutalika kwa nthawi ya Q-T, kosowa kwambiri - kunachepetsa kuthamanga kwa magazi, vasodilation,

Kuchokera pakapumidwe:: kawirikawiri - kufupika, kawirikawiri - mphumu la bronchial.

Kuchokera ku minculoskeletal system: kawirikawiri - arthralgia, myalgia, osowa kwambiri - kupweteka kumbuyo, kupweteka kwa mwendo, nyamakazi, tendopathy.

Kuchokera ku genitourinary system: kawirikawiri - vagidi candidiasis, vaginitis, kawirikawiri - ululu wam'mimba, kutupa kwa nkhope, zotumphukira edema, kuwonongeka kwaimpso.

Thupi lawo siligwirizana: kawirikawiri - zidzolo, kuyabwa, kawirikawiri - urticaria, anaphylactic mantha.

Zomwe zimachitika mdelalo: nthawi zambiri - edema, kutupa, kupweteka pamalo jakisoni, kawirikawiri - phlebitis.

Zowonetsa zasayansi: kawirikawiri - leukopenia, kuchuluka kwa prothrombin, eosinophilia, thrombocytosis, kuchuluka kwa zochitika za amylase, kawirikawiri kwambiri - kuchepa kwa nthawi ya thromboplastin, kuchepa kwa prothrombin nthawi, thrombocytopenia, kuchepa magazi, hyperglycemia, hyperlipidemia, hyperlipidemia, hyperlipidemia, hyperlipidemia. Kulumikizana ndi kayendetsedwe ka mankhwala sikunasonyezedwe: kuwonjezeka kapena kuchepa kwa hematocrit, leukocytosis, erythrocytosis kapena erythropenia, kuchepa kwa kuchuluka kwa shuga, Hb, urea, kuchuluka kwa ntchito za alkaline phosphatase.

Zina: kawirikawiri - candidiasis, kusapeza bwino, thukuta.

Malangizo apadera

Mankhwalawa ndi fluoroquinolones, kutupa ndi kupindika kwa tendon kumatha kukula, makamaka kwa odwala okalamba komanso odwala omwe akulandira nthawi yomweyo corticosteroids. Pazizindikiro zoyambirira za kupweteka kapena kutupa kwa matendawa, odwala ayenera kusiya kulandira chithandizo ndikukulitsa dzanja.

Pali kulumikizana mwachindunji pakati pa kuwonjezeka kwa kuchuluka kwa moxifloxacin ndi kuwonjezeka kwa gawo la Q-T (chiopsezo chotukula kwamitsempha yam'mimba, kuphatikizapo torsades de pointes). Zotsatira zake, mlingo woyenera (400 mg) sayenera kupitilira ndipo kulowetsedwa kuyenera kufulumira (osachepera mphindi 60).

Pankhani ya kutsegula m'mimba kwambiri pamankhwala, mankhwalawa ayenera kusiyidwa.

Kuchita

Maantacid, mineral, multivitamini amalepheretsa mayamwidwe (chifukwa cha mapangidwe a chelate owundana ndi ma polyvalent cations) ndikuchepetsa kuchuluka kwa moxifloxacin mu plasma (munthawi yomweyo makonzedwe amatha kuchitika pakadutsa maola 4 isanachitike kapena 2 mawola atamwa moxifloxacin.

Kugwiritsa ntchito mosemphana ndi ma quinolones ena kumawonjezera chiopsezo chowonjezera nthawi ya Q-T.

Pang'onopang'ono zimakhudza magawo a pharmacokinetic a digoxin.

GCS imakulitsa chiopsezo cha tendovaginitis kapena kupindika kwa tendon.

Njira yothetsera imayenderana ndi njira zotsatirazi zamafuta: 0.9% ndi 1 molar NaCl yankho, madzi a jakisoni, yankho la dextrose (5, 10 ndi 40%), 20% xylitol yankho, yankho la Ringer, Ringer-lactate, 10% Aminofusin yankho, yankho Yonosteril.

Zosagwirizana ndi 10 ndi 20% NaCl njira, 4.2 ndi 8.4% Na bicarbonate yankho.

Kutulutsa mawonekedwe ndi kapangidwe kake

Kutulutsidwa kwa mankhwalawa ndi mapiritsi okhala ndi filimu. Piritsi lililonse lili ndi 436.4 mg ya moxifloxacin hydrochloride, yomwe imafanana ndi 400 mg ya moxifloxacin. Zinthu zazing'ono:

• Utoto wofiira wa oxide,
• hydroxypropyl methylcellulose,
• magnesium wakuba,
• MCC
• sodium croscarmellose,
• lactose monohydrate.

Mankhwalawa amayikidwa m'matumba a 5, 7 kapena 10 ma PC. kapena m'mabotolo a polymer a 100, 500 kapena 1000 ma PC. (ku mabungwe azachipatala). Bokosilo limatha kukhala ndi matuza 1, 2 kapena botolo imodzi ya polymer.

Mankhwala

Mankhwalawa ndi mankhwala a fluoroquinolone ndipo ali ndi vuto la bacteria.

Ma grorgan-aerobic tizilombo tosiyanasiyana amakhala ndi chidwi chosiyanasiyana ndi zomwe mankhwalawa amapanga.

Chigawo chake chogwira ntchito chimakhudzanso kuphatikizika kwa DNA ya tizilombo tating'onoting'ono, motero timathandizira kuti afe mwachangu. Ma gror-positive aerobes amazindikira izi: Staphylococcus aureus, Streptococcus dysgalactiae, Streptococcus mitis, Staphylococcus saprophyticus, Streptococcus agalactiae, Staphylococcus hominis, Haemophilias parainfluenzae, Enterobacter ccelae.

Ma grram-negative aerobic tizilombo tomwe timakhala ndi magawo osiyanasiyana a chidwi cha zomwe mankhwalawa ali: Porphyromonas asaccharolyticus, Bacteroides ovatus, Porphyromonas asaccharolyticus, Prevotella spp. Mycoplasma pneumonia, Coxiella bumettii.

Kuzindikira kwapakati pa antibayotiki ndi awa: Stenotrophomonas maltophilia, Burkholdera cepacia, Pseudomonas aeruginosa.

Mlandu wotsutsa mtanda wa mankhwala ena kuchokera ku gulu la fluoroquinolones adalembedwa.

Contraindication

Malangizowa amaletsa kupaka mankhwala ngati:

• matenda ashuga
• khunyu
• kutsegula m'mimba kwambiri
• osakwana zaka 18
• hypokalemia yosalamulirika,
• nyere
• mimba

Chenjezo bactericidal wothandizila ayenera kumwedwa ndi hepatic pathologies, hypokalemia, zopweteka, nthawi yayitali QT, pseudomembranous colitis, kuphatikiza corticosteroids. Kuphatikiza apo, mankhwalawa ayenera kuikidwa mosamala kwa odwala omwe akudwala hemodialysis.

Bongo

Wodwala amatha kukhudzidwa, kunjenjemera, kutsegula m'mimba, kusanza, ndi kugona pamene akugwiritsa ntchito mankhwala osokoneza bongo ambiri.

Chithandizocho chimaphatikizapo kuyeretsa kwamatumbo komanso kugwiritsa ntchito mankhwala ochepetsa.

Njira zina ndizodziwikiratu ndipo ziyenera kuchitika moyang'aniridwa ndi chizindikiro cha ECG. Katemera wa chinthucho kulibe.

Kuyanjana kwa mankhwala osokoneza bongo

Akaphatikizidwa ndi mankhwalawa, mchere, maantacididi, ma multivitamini amathandizira kuyamwa kwake ndikuchepetsa plasma.

Kugwiritsa ntchito maantibayotiki limodzi ndi mitundu ina ya quinolones kumabweretsa mawonekedwe awowonetsa.

Ranitidine amachepetsa kuyamwa kwa moxifloxacin.

Mtengo mumafakisi

Mtengo wa antibayotiki umayamba kuchokera ku ma ruble 620. ndi mapiritsi 5 a paketi.

Ngati pali contraindication kwa mankhwalawo kapena kusapezeka kwake mu mankhwala panthawi yogula, mutha kuyambitsa chidwi ndi chimodzi mwazomwezi:

• Maxiflox
• Alvelon-MF,
• Achimoax
• Avelox,
• Moksimak,
• Megaflox,
• Moxigram
• Vigamox
• Moxiflo
• Moxystar
• Moxispenser
• Moxifloxacin Canon,
• Moxifloxacin hydrochloride,
• Moxifloxacin-Optic,
• Moxifloxacin-Alvogen,
• Moxifur
• Simoflox,
• Ultramox
• Moflaxia,
• Heinemox.

Boris Belyaev (urologist), mzinda wa Balakovo

Wachinayi m'badwo wa mankhwala fluoroquinolone. Zotsatira zake zili pafupifupi 100% zodziwikiratu. Zotsatira zoyipa ndizochepa kwambiri. Ndikupereka mankhwala osokoneza mankhwalawa.

Tatyana Sidorova, wazaka 38, mzinda wa Dzerzhinsk

Mothandizidwa ndi antibacterial mankhwalawa, ndidachiritsidwa mycoplasmosis. Mlingo wovomerezeka - 1 nthawi patsiku, palibenso njira zina zobwererera matendawa kapena chizindikiro chilichonse. Izi zimatheka m'masiku 8-9 atamwa mankhwalawo.

Kristina Verina, wazaka 25, mzinda wa Zelenogorsk

Kuchipatalako, adandipeza ndi mtundu wa chibayo, pambuyo pake adandiika kuchipatala masiku 10. Ngati adagulitsidwa ku chithandizo chamankhwala kunja, mankhwalawa adapangidwa limodzi ndi doxycycline. Sindinawone zotsatira zoyipa zomwe zikuwonetsedwa mu malangizowo, panalibe zodandaulitsa panthawi yonse yomwe mumamwa mankhwalawo. Tsopano ndachira komanso kumva bwino.

Vera Ignatyeva, wazaka 34, mzinda wa Kalach-on-Don

Nditakumana ndi cystitis, ndidayamba kugwiritsa ntchito Aquamox, koma ndidakumana nazo. Adotolo adalowa m'malo mwake ndi plevilox. Thupi langa modekha linamwa mankhwalawa. Matendawa adathetsedwa mu 1.5 milungu yokhazikika yoyendetsedwa ndi mankhwalawa mu Mlingo wosonyezedwa.

Mimba komanso kuyamwa

Chitetezo cha moxifloxacin pa nthawi yapakati sichinakhazikitsidwe.

Zowonongeka zomwe zimasinthidwa zafotokozedwanso kwa ana omwe amathandizidwa ndi mankhwala ena a quinolone, koma zotulukapo zofananira zomwe zimachitika pakakhala mwana wosabadwayo sizinanenedwe. Kafukufuku wazinyama amawonetsa kawopsedwe ochulukitsa.

Kugwiritsa ntchito moxifloxacin pa nthawi ya pakati kumatsutsana.

Monga mankhwala ena a quinolone, moxifloxacin imawononga kwambiri kukulira ndi kufalikira kwa minofu yolumikizira mafupa othandizira mu nyama zosakhwima.

Pafupipafupi moxifloxacin amamuchotsa mkaka wa m'mawere. Zomwe zimagwiritsidwa ntchito moxifloxacin mwa azimayi panthawi yanthawi yoyipa ndi kudya sizipezeka.

Kugwiritsa ntchito moxifloxacin mwa amayi oyamwitsa kumatsutsana.

Deta Yotetezera

Pophunzira kulekerera agalu, kunalibe zizindikilo zokhudzana ndi kulekerera moxifloxacin kudzera m'mitsempha. Pambuyo pamakonzedwe a intraarterial, kusintha kwa kutupa komwe kunkachitika pokhudzana ndi minofu yofewa ya periarterial, zomwe zikuwonetsa kuti ma intraarterial makonzedwe a moxifloxacin ayenera kupewedwa.

Mlingo ndi makonzedwe

Akuluakulu

Mlingo wa Plevilox 400 mg (piritsi 1) kamodzi pa maola 24 aliwonse. Kutalika kwa mankhwalawa kumatengera mtundu wa matenda, monga momwe tafotokozera 1.

Gometi 1: Mlingo ndi nthawi yayitali ya mankhwala odwala akulu

Mlingo uliwonse maola 24

Kutalika b (masiku)

Pachimake bakiteriya sinusitis

Bakiteriya achulukitsa a bronchitis

Matenda osakhazikika a pakhungu ndi kapangidwe kake

Matenda ovuta a pakhungu ndi kapangidwe kake

Matenda Ovuta a Intraabdominal

Choyambitsa ndi tizilombo toyambitsa matenda pamwambapa (onani gawo "Zizindikiro Zogwiritsira Ntchito").

6 Mathandizidwe othandizirana (kudzera m'mitsempha kenako pakamwa) atha kuthandizidwa ndi adokotala.

Kuwongolera kwa msana kumasonyezedwa ngati njira yolamulirayo ndiyabwino kwambiri kwa wodwala (mwachitsanzo, wodwalayo sangatenge fomu ya pakamwa). Mukasintha kuchokera kukapakati kwamkati kupita pakamwa, makonzedwe a mankhwala safunikira. Odwala omwe mankhwalawa amayamba ndi mtsempha wa magazi wa moxifloxacin amatha kuthandizidwa ndi mapiritsi molingana ndi mawonekedwe azachipatala pakuwona kwa dokotala.

Chiwerengero Chapadera

Okalamba ndi odwala omwe ali ndi thupi lochepa, kusintha kwa mankhwala sikofunikira.

Moxifloxacin amaphatikizidwa kwa ana ndi achinyamata (

Zolemba zogwiritsira ntchito

Zoopsa zobereka

Mukamaphunzira za moxifloxacin pa ntchito yobereka makoswe, akalulu ndi nyani, zimatsimikiziridwa kuti moxifloxacin amawoloka placenta. Kafukufuku wama makoswe (mukamagwiritsa ntchito moxifloxacin pakamwa komanso m'mitsempha) ndi anyani (mukamagwiritsa ntchito moxifloxacin mkati) sanawululire za mphamvu ya teratogenic ya moxifloxacin komanso momwe zimakhudzira chonde. Pogwiritsa ntchito moxifloxacin mozama mkati mwa kalulu 20 mg / kg, kuwonongeka kwa mafupa kunawonedwa. Izi ndizofanana poyerekeza ndi zotsatira zomwe zadziwika za quinolones pakukula kwa mafupa. Kuwonjezeka kwa matenda olakwika a anyani ndi akalulu kunaululidwa pogwiritsa ntchito moxifloxacin mu mankhwala othandizira. Mu makoswe, panali kuchepa kwa fetal kulemera, kuwonjezeka kwa padera, kuwonjezeka pang'ono kwa nthawi yodzala ndi kuchuluka kwa zochita za ana a amuna ndi akazi onse mukugwiritsa ntchito moxifloxacin, mlingo womwe anali wokwera nthawi makumi asanu ndi limodzi ndi umodzi kuposa womwe unathandizidwa ndi anthu.

Zotsatira pa kuthekera koyendetsa magalimoto ndi zina zomwe zili zoopsamachitidwe

Fluoroquinolones, kuphatikiza moxifloxacin, imatha kubweretsa vuto lotha kuyendetsa magalimoto kapena njira zina zoopsa chifukwa cha zochita zamagetsi apakati.

Njira zopewera kupewa ngozi

Nthawi zina, mankhwalawa akagwiritsidwa ntchito koyamba, Hypersensitivity ndi thupi lawo siligwirizana. Nthawi zambiri, zotsatira za anaphylactic zimatha kupitilira mpaka pakubwezeretsa pangozi ya anaphylactic, ngakhale atangoyamba kugwiritsa ntchito mankhwalawa. Milandu iyi, moxifloxacin iyenera kusiyidwa ndipo njira zoyenera zothandizira zimatengedwa (kuphatikizapo anti-shock).

Milandu ya chiwindi chachikulu cha hepatitis yanenedwapo, zomwe zingayambitse chiwopsezo cha chiwopsezo cha moyo, kuphatikizapo imfa. Ngati zizindikiro za kulephera kwa chiwindi zikuwonekera, odwala ayenera kufunsa dokotala nthawi yomweyo asanapitirize chithandizo.

Ngati pakhungu pakukhudzana ndi / komanso pakhungu pakhungu lanu, muyenera kufunsa dokotala nthawi yomweyo musanapitirize chithandizo. Kugwiritsa ntchito mankhwala a quinolone kumalumikizidwa ndi chiopsezo chogwira gwiridwe. Moxifloxacin iyenera kugwiritsidwa ntchito mosamala kwa odwala omwe ali ndi matenda amkatikati mwa mitsempha komanso mikhalidwe yomwe akukayikira pakukhudzidwa kwapakati pamitsempha yamagetsi, poganiza kuti pakubwera kugunda kotsitsimula, kapena kutsitsa poyambira kuti agwire.

Kugwiritsa ntchito mitundu yotakata ya antibacterial, kuphatikiza moxifloxacin, kumalumikizidwa ndi chiopsezo chotenga pseudomembranous colitis yokhudzana ndi kumwa maantibayotiki. Kuzindikiritsa izi kuyenera kukumbukiridwa mwa odwala omwe amatenga matenda otsekula m'mimba panthawi ya mankhwala a moxifloxacin. Pankhaniyi, chithandizo choyenera chikuyenera kuperekedwa nthawi yomweyo. Odwala omwe ali ndi matenda otsegula m'mimba amatsutsana ndi mankhwala omwe amaletsa matumbo kuyenda.

Moxifloxacin ayenera kugwiritsidwa ntchito mosamala odwala omwe ali ndi Gravis myasthenia gravis, chifukwa mankhwalawa amatha kupititsa patsogolo zizindikiro za matendawa. Pa mankhwala a fluoroquinolones, kuphatikizapo moxifloxacin, makamaka odwala okalamba omwe amalandila glucocorticosteroids, tendonitis ndi kupasuka kwa tendon angayambike. Pazizindikiro zoyambirira za kupweteka kapena kutupa pamalo ovulala, mankhwalawa amayenera kuyimitsidwa ndikugwedezedwa.

Kwa odwala omwe ali ndi zovuta zotupa za ziwalo zamkati (mwachitsanzo, zimagwirizanitsidwa ndi tubo-ovarian kapena pelvic abscesses) omwe amathandizidwa ndi chithandizo chamkati, kugwiritsa ntchito moxifloxacin mu mapiritsi a 400 mg sikulimbikitsidwa.

Pogwiritsa ntchito quinolones, mawonekedwe a photosensitivity amadziwika. Komabe, pa preclinical, maphunziro azachipatala, komanso kugwiritsa ntchito moxifloxacin pochita, palibe zotsatira zamtundu wa photosensitivity zomwe zimawonedwa. Komabe, odwala omwe amalandila moxifloxacin ayenera kupewa kuwala kwa dzuwa mwachindunji ndi ma radiation a ultraviolet.

Kutalikirana kwakanthawiQTckomanso zovuta zokhudzana ndi matenda

Zinapezeka kuti moxifloxacin amachulukitsa nthawi ya QTc pama electrocardiograms a odwala ena. Panthawi yowunikira ma ECG omwe adapezeka ngati gawo la pulogalamu yoyeserera kuchipatala, kutalika kwa gawo la QTc pamene amatenga moxifloxacin anali 6 milliseconds ± 26 milliseconds, omwe ndi 1.4% poyerekeza ndi gawo loyambirira. Chifukwa chakuti kutalika koyambirira kwa gawo la QTc mwa akazi ndikutalika kuposa amuna, azimayi amatha kutengeka ndi zomwe mankhwala omwe amapangitsa QTc kupitilira. Anthu achikulire amathanso kutenga zovuta za mankhwalawa pakanthawi ka QT.

Kuchulukitsa kwa nthawi ya QT kumatha kuwonjezeka ndi kuchuluka kwa mankhwalawa, motero mlingo woyenera sayenera kupitirira. Kutalika kwa nthawi ya QT kumalumikizidwa ndi chiwopsezo chowonjezeka cha chamitsempha yama cell, kuphatikiza polymorphic ventricular tachycardia. Komabe, odwala chibayo palibe kulumikizana pakati pa kuchuluka kwa moxifloxacin m'madzi a m'magazi komanso kutalika kwa nthawi ya QT. Palibe mwa 9,000 odwala omwe amathandizidwa ndi moxifloxacin omwe anali ndi zovuta zamtima komanso kufa chifukwa chokhala ndi kuchuluka kwa QT. Komabe, mwa odwala omwe ali ndi vuto lodziwika kuti ali ndi vuto losagwirizana, kugwiritsa ntchito moxifloxacin kungakulitse chiopsezo cha ventricular arrhythmias.

Pankhaniyi, makonzedwe a moxifloxacin ayenera kupewedwa kwa odwala omwe ali ndi nthawi yayitali ya QT, hypokalemia yopanda tanthauzo, komanso mwa omwe amalandila mankhwala a antiarrhythmic a kalasi ya quinidine, procainamide kapena kalasi III (amiodarone, sotalol), popeza momwe amamugwiritsira ntchito moxifloxacin mwa odwalawa organic. Moxifloxacin ayenera kuikidwa mosamala, popeza zowonjezera za moxifloxacin sizitha kuyikidwa pambali izi:

Odwala amalandila chithandizo chofanana ndi mankhwala omwe amalimbikitsa QT nthawi yayitali (chisapride, erythromycin, antipsychotic mankhwala, tricyclic antidepressants),

Odwala omwe ali ndi vuto lotha kupanga arrhythmias, monga bradycardia yofunika kwambiri, pachimake myocardial ischemia,

odwala odwala matenda amitsempha, popeza kukhalapo kwa nthawi yayitali ya QT mwa iwo sikungathere kunja,

mwa amayi kapena odwala okalamba omwe amatha chidwi kwambiri ndi mankhwala omwe amawonjezera nthawi ya QT,

Ngati zizindikiro za mtima zapamwala zikuchitika pa mankhwala a moxifloxacin, muyenera kusiya kumwa mankhwalawo ndikupanga ECG.

Plevilox mankhwala: malangizo ntchito

Mankhwala othandizira Plevilox amakupatsani mwayi wolimbana ndi matenda ambiri, omwe amathandizira omwe ali ndi tizilombo tating'onoting'ono tomwe timayang'anira ntchito yake. Komabe, mankhwalawa amayenera kuyikidwa ndi katswiri kokha, chifukwa kudzipereka nokha kungayambitse zotsatira zosakonzekera.

Plevilox imakupatsani mwayi wolimbana ndi matenda ambiri, omwe amathandizira omwe ali ndi tizilombo tating'onoting'ono tomwe timayang'ana kuchitapo chake.

14 Analogi

Ngati pali contraindication kwa mankhwalawo kapena kusapezeka kwake mu mankhwala panthawi yogula, mutha kuyambitsa chidwi ndi chimodzi mwazomwezi:

• Maxiflox
• Alvelon-MF,
• Achimoax
• Avelox,
• Moksimak,
• Megaflox,
• Moxigram
• Vigamox
• Moxiflo
• Moxystar
• Moxispenser
• Moxifloxacin Canon,
• Moxifloxacin hydrochloride,
• Moxifloxacin-Optic,
• Moxifloxacin-Alvogen,
• Moxifur
• Simoflox,
• Ultramox
• Moflaxia,
• Heinemox.

Boris Belyaev (urologist), mzinda wa Balakovo

Wachinayi m'badwo wa mankhwala fluoroquinolone. Zotsatira zake zili pafupifupi 100% zodziwikiratu. Zotsatira zoyipa ndizochepa kwambiri. Ndikupereka mankhwala osokoneza mankhwalawa.

Tatyana Sidorova, wazaka 38, mzinda wa Dzerzhinsk

Mothandizidwa ndi antibacterial mankhwalawa, ndidachiritsidwa mycoplasmosis. Mlingo wovomerezeka - 1 nthawi patsiku, palibenso njira zina zobwererera matendawa kapena chizindikiro chilichonse. Izi zimatheka m'masiku 8-9 atamwa mankhwalawo.

Kristina Verina, wazaka 25, mzinda wa Zelenogorsk

Kuchipatalako, adandipeza ndi mtundu wa chibayo, pambuyo pake adandiika kuchipatala masiku 10. Ngati adagulitsidwa ku chithandizo chamankhwala kunja, mankhwalawa adapangidwa limodzi ndi doxycycline. Sindinawone zotsatira zoyipa zomwe zikuwonetsedwa mu malangizowo, panalibe zodandaulitsa panthawi yonse yomwe mumamwa mankhwalawo. Tsopano ndachira komanso kumva bwino.

Vera Ignatyeva, wazaka 34, mzinda wa Kalach-on-Don

Nditakumana ndi cystitis, ndidayamba kugwiritsa ntchito Aquamox, koma ndidakumana nazo. Adotolo adalowa m'malo mwake ndi plevilox. Thupi langa modekha linamwa mankhwalawa. Matendawa adathetsedwa mu 1.5 milungu yokhazikika yoyendetsedwa ndi mankhwalawa mu Mlingo wosonyezedwa.

Angelina Marinina, wazaka 44, mzinda wa Vladimir

Anathandizidwa ndi mapiritsi awa a chibayo. Maantibayotiki othandiza omwe amathandiza mwachangu. Komabe, nditagwiritsa ntchito mankhwalawa, ndinayamba kusangalala. Dotolo adati izi ndizofala. Ndinaphatikizanso kuphatikiza kumwa a Diflucan.

Plevilox kumasulidwa fomu

Mapiritsi 400 okhala ndi mafilimu okhala ndi 400 mg, blister 5 paketi ya makatoni 1,

400 mg mapiritsi okhala ndi mafilimu, matumba 7 a makatoni 1,

Mapiritsi 400 okhala ndi mafilimu okhala ndi 400 mg, chithuza 10 cha makatoni 1,

400 mg mapiritsi okhala ndi mafilimu, matumba 7 a makatoni 2,

400 mg mapiritsi okhala ndi mafilimu, matumba 10 a makatoni 2,

Mapiritsi a 400 mg okhala ndi mafilimu, thumba la polyethylene (sachet) 100 angathe (jar) polymer 1,
Mapiritsi a 400 mg okhala ndi mafilimu, thumba la pulasitiki (sachet) 500 akhoza (jar) polima 1,
Mapiritsi a 400 mg okhala ndi mafilimu, thumba la pulasitiki (sachet) 1000 amatha (jar) polima 1,

Gulu la ATX:

J Ma Antimicrobials ogwiritsa ntchito mwadongosolo

Mankhwala opatsirana a J01 kuti mugwiritse ntchito pafupipafupi

Ma antibacterials a J01M - zotengera za quinolone

Zolemba za Plevilox ya mankhwala omwe adalembedwa patsamba lino la tsamba lathu zitha kugwiritsidwa ntchito tsiku lililonse.

Mankhwala osokoneza bongo

Zizindikiro: mwina kuchepa kwa ntchito, kugona, kusanza, kutsegula m'mimba, kunjenjemera kwa thupi, kukomoka. Chithandizo: chapamimba (mu maora awiri atatha bongo), kuwunikira, kuwonetsa chizindikiro ndi kuwunika kwa ECG. Palibenso mankhwala enaake othandizira. Ndikofunikira kuonetsetsa kuti madzi azilowa mthupi limodzi ndikukhalitsa okwanira.

Malangizo apadera ogwiritsira ntchito mankhwalawa

Pofuna kuchepetsa chiopsezo chotenga kukana kwa moxifloxacin ndi kukhalabe ndi mphamvu ya antibacterial othandizira, moxifloxacin amayenera kugwiritsidwa ntchito pochiza matenda omwe amayamba chifukwa cha zovuta za mankhwalawa. Mankhwalawa, kuwunika kwa ECG ndikofunikira (kutalika kwa nthawi ya QT, ventricular arrhythmias). Kuchulukitsa kwa nthawi ya QT kumatha kuwonjezeka ndi kuchuluka kwa mankhwalawa, motero mlingo woyenera sayenera kupitirira. Kutalika kwa nthawi ya QT kumalumikizidwa ndi chiopsezo chowonjezeka cha regricular arrhythmias, kuphatikizapo flicker-flutter. Pa mankhwala a fluoroquinolones, kuphatikizapo moxifloxacin, makamaka odwala okalamba omwe amalandila glucocorticosteroids, kukulitsa kwa tendonitis ndi kupasuka kwa tendon ndikotheka. Pazizindikiro zoyambirira za kupweteka kapena kutupa pamalo ovulala, mankhwalawa amayenera kuyimitsidwa ndikugwedezedwa. Pankhani ya matenda otsekula m'mimba pakumwa mankhwala a moxifloxacin, mankhwalawa ayenera kusiyidwa ndi kupatsidwa mankhwala oyenera. Nthawi zina, thupi limakhala ndi zotsatira zoyipa kwambiri, kuphatikizapo kuopseza kwa anaphylactic. Milandu iyi, moxifloxacin iyenera kuthetsedwa ndipo zofunikira (kuphatikizapo anti-shock) zotchulidwa ziyenera kulembedwa: glucocorticosteroids, norepinephrine, antihistamines. Moxifloxacin alibe malo okhala ndi zithunzi. Komabe, odwala omwe amalandila moxifloxacin ayenera kupewa kuwala kwa dzuwa mwachindunji ndi ma radiation a ultraviolet. Ngakhale kuti moxifloxacin samakonda kuyambitsa zovuta kuchokera ku mtima wamanjenje, odwala ayenera kudziwa momwe amvera mankhwalawo asanayendetse galimoto / makina osunthira.