Metformin-Teva analogues
Tsambali limapereka mndandanda wazofanana zonse za Metformin-Teva mu kapangidwe kake ndikuwonetsa kuti mugwiritse ntchito. Mndandanda wama analogi otsika mtengo, mutha kuyerekezeranso mitengo muma pharmacies.
- Analogue yotsika mtengo kwambiri ya Metformin-Teva:Glucophage
- Analogue yotchuka kwambiri ya Metformin-Teva:Metformin
- Gulu la ATX: Metformin
- Zosakaniza / yogwira: metformin
| # | Mutu | Mtengo ku Russia | Mtengo ku Ukraine |
|---|---|---|---|
| 1 | Glucophage metformin Kuwonetsa mu kapangidwe kake ndi chisonyezo | 12 rub | 15 UAH |
| 2 | Metformin metformin Kuwonetsa mu kapangidwe kake ndi chisonyezo | 13 rub | 12 UAH |
| 3 | Reduxin Met metformin, sibutramine Kuwonetsa mu kapangidwe kake ndi chisonyezo | 20 rub | -- |
| 4 | Metformin Canon metformin, ovidone K 90, wowuma chimanga, crospovidone, magnesium stearate, talc Kuwonetsa mu kapangidwe kake ndi chisonyezo | 26 rub | -- |
| 5 | Fotokozani Analogue pamapangidwe ndi chisonyezo | 37 rub | -- |
Mukamawerengera mtengo wake zotupa zotsika mtengo Metformin-Teva mtengo wocheperako womwe umapezeka mumndandanda wamapulogalamu omwe amaperekedwa ndi ma pharmacies adaganiziridwa
| # | Mutu | Mtengo ku Russia | Mtengo ku Ukraine |
|---|---|---|---|
| 1 | Metformin metformin Kuwonetsa mu kapangidwe kake ndi chisonyezo | 13 rub | 12 UAH |
| 2 | Reduxin Met metformin, sibutramine Kuwonetsa mu kapangidwe kake ndi chisonyezo | 20 rub | -- |
| 3 | Siofor Analogue mu kapangidwe kake ndi chisonyezo | 208 rub | 27 UAH |
| 4 | Glucophage metformin Kuwonetsa mu kapangidwe kake ndi chisonyezo | 12 rub | 15 UAH |
| 5 | Fotokozani Analogue pamapangidwe ndi chisonyezo | 37 rub | -- |
Popeza mndandanda wamankhwala osokoneza bongo kutengera manambala a mankhwala omwe apemphedwa kwambiri
Analogs popanga ndi chisonyezo chogwiritsidwa ntchito
| Mutu | Mtengo ku Russia | Mtengo ku Ukraine |
|---|---|---|
| Bagomet Metformin | -- | 30 UAH |
| Glucofage metformin | 12 rub | 15 UAH |
| Glucophage xr metformin | -- | 50 UAH |
| Reduxin Met Metformin, Sibutramine | 20 rub | -- |
| Dianormet | -- | 19 UAH |
| Diaformin metformin | -- | 5 UAH |
| Metformin metformin | 13 rub | 12 UAH |
| Metformin sandoz metformin | -- | 13 UAH |
| Siofor | 208 rub | 27 UAH |
| Fomu metformin hydrochloride | -- | -- |
| Emnorm EP Metformin | -- | -- |
| Megifort Metformin | -- | 15 UAH |
| Metamine Metformin | -- | 20 UAH |
| Metamine SR Metformin | -- | 20 UAH |
| Metfogamma metformin | 256 rub | 17 UAH |
| Tefor metformin | -- | -- |
| Glycometer | -- | -- |
| Glycomet SR | -- | -- |
| Forethine | 37 rub | -- |
| Metformin Canon metformin, ovidone K 90, wowuma chimanga, crospovidone, magnesium stearate, talc | 26 rub | -- |
| Insuffor metformin hydrochloride | -- | 25 UAH |
| Diaformin SR metformin | -- | 18 UAH |
| Mepharmil Metformin | -- | 13 UAH |
| Metformin Farmland Metformin | -- | -- |
Mndandanda womwe uli pamwambapa wa analogies ya mankhwala, omwe akuwonetsa Olemba a Metformin-Teva, ndizabwino kwambiri chifukwa zimakhala ndi zinthu zomwe zimagwirizana ndipo zimagwirana molingana ndi chisonyezo chogwiritsidwa ntchito
Kuphatikizika kosiyanasiyana, kungagwirizane mukuwonetsa ndikugwiritsa ntchito njira
| Mutu | Mtengo ku Russia | Mtengo ku Ukraine |
|---|---|---|
| Rosiglitazone wothandiza, metformin hydrochloride | -- | -- |
| Glibenclamide Glibenclamide | 30 rub | 7 UAH |
| Maninyl Glibenclamide | 54 rub | 37 UAH |
| Glibenclamide-Health Glibenclamide | -- | 12 UAH |
| Glyurenorm glycidone | 94 rub | 43 UAH |
| Bisogamma Glyclazide | 91 rub | 182 UAH |
| Glidiab Glyclazide | 100 rub | 170 UAH |
| Diabeteson MR | -- | 92 UAH |
| Diagnizide mr Gliclazide | -- | 15 UAH |
| Glidia MV Gliclazide | -- | -- |
| Glykinorm Gliclazide | -- | -- |
| Gliclazide Gliclazide | 231 rub | 57 UAH |
| Glyclazide 30 MV-Indar Glyclazide | -- | -- |
| Glyclazide-Health Gliclazide | -- | 36 UAH |
| Glioral Glyclazide | -- | -- |
| Diagnizide Gliclazide | -- | 14 UAH |
| Diazide MV Gliclazide | -- | 46 UAH |
| Osliklid Gliclazide | -- | 68 UAH |
| Diadeon gliclazide | -- | -- |
| Glyclazide MV Gliclazide | 4 rub | -- |
| Amaril | 27 rub | 4 UAH |
| Glemaz glimepiride | -- | -- |
| Glian glimepiride | -- | 77 UAH |
| Glimepiride Glyride | -- | 149 UAH |
| Glimepiride diapiride | -- | 23 UAH |
| Guwa | -- | 12 UAH |
| Glimax glimepiride | -- | 35 UAH |
| Glimepiride-Lugal glimepiride | -- | 69 UAH |
| Clay glimepiride | -- | 66 UAH |
| Diabrex glimepiride | -- | 142 UAH |
| Meglimide glimepiride | -- | -- |
| Melpamide Glimepiride | -- | 84 UAH |
| Perinel glimepiride | -- | -- |
| Glempid | -- | -- |
| Wokongola | -- | -- |
| Glimepiride glimepiride | 27 rub | 42 UAH |
| Glimepiride-teva glimepiride | -- | 57 UAH |
| Glimepiride Canon glimepiride | 50 rub | -- |
| Glimepiride Pharmstandard glimepiride | -- | -- |
| Dimaril glimepiride | -- | 21 UAH |
| Glamepiride diamerid | 2 rub | -- |
| Amaryl M Limepiride Micronized, Metformin Hydrochloride | 856 rub | 40 UAH |
| Glibomet glibenclamide, metformin | 257 rub | 101 UAH |
| Glucovans glibenclamide, metformin | 34 rub | 8 UAH |
| Dianorm-m Glyclazide, Metformin | -- | 115 UAH |
| Dibizid-m glipizide, metformin | -- | 30 UAH |
| Douglimax glimepiride, metformin | -- | 44 UAH |
| Duotrol glibenclamide, metformin | -- | -- |
| Gluconorm | 45 rub | -- |
| Glibofor metformin hydrochloride, glibenclamide | -- | 16 UAH |
| Avandamet | -- | -- |
| Avandaglim | -- | -- |
| Janumet metformin, sitagliptin | 9 rub | 1 UAH |
| Velmetia metformin, sitagliptin | 6026 rub | -- |
| Galvus Met vildagliptin, metformin | 259 rub | 1195 UAH |
| Tripride glimepiride, metformin, pioglitazone | -- | 83 UAH |
| Comboglize XR metformin, saxagliptin | -- | 424 UAH |
| Comboglyz Prolong metformin, saxagliptin | 130 rub | -- |
| Gentadueto linagliptin, metformin | -- | -- |
| Vipdomet metformin, alogliptin | 55 rub | 1750 UAH |
| Sinjardi empagliflozin, metformin hydrochloride | 240 rub | -- |
| Voglibose Oxide | -- | 21 UAH |
| Glutazone pioglitazone | -- | 66 UAH |
| Dropia Sanovel pioglitazone | -- | -- |
| Januvia sitagliptin | 1369 rub | 277 UAH |
| Galvus vildagliptin | 245 rub | 895 UAH |
| Onglisa saxagliptin | 1472 rub | 48 UAH |
| Nesina alogliptin | -- | -- |
| Vipidia alogliptin | 350 rub | 1250 UAH |
| Trazhenta linagliptin | 89 rub | 1434 UAH |
| Lixumia lixisenatide | -- | 2498 UAH |
| Malo a Guarem Guar | 9950 rub | 24 UAH |
| Insvada repaglinide | -- | -- |
| Novonorm Repaglinide | 30 rub | 90 UAH |
| Repodiab Repaglinide | -- | -- |
| Baeta Exenatide | 150 rub | 4600 UAH |
| Baeta Long Exenatide | 10248 rub | -- |
| Viktoza liraglutide | 8823 rub | 2900 UAH |
| Saxenda liraglutide | 1374 rub | 13773 UAH |
| Forksiga Dapagliflozin | -- | 18 UAH |
| Forsiga Dapagliflozin | 12 rub | 3200 UAH |
| Invocana canagliflozin | 13 rub | 3200 UAH |
| Jardins Empagliflozin | 222 rub | 566 UAH |
| Trulicity Dulaglutide | 115 rub | -- |
Kodi mungapeze bwanji analogue yotsika mtengo ya mankhwala okwera mtengo?
Kuti mupeze chiwonetsero chotsika mtengo cha mankhwala, chofananira kapena chofanana, choyambirira timalimbikitsa kulabadira kapangidwe kake, zomwe ndi zinthu zomwezo zomwe zikugwira komanso zomwe zikugwiritsidwa ntchito. Zomwe zimagwiritsidwanso mosiyanasiyana ndi mankhwalawa zimawonetsa kuti mankhwalawo ndi ofanana ndi mankhwalawo, monga mankhwala ena kapena mitundu ina. Komabe, musaiwale za zovuta zomwe zimagwiritsidwa ntchito ndi mankhwala ofanana, omwe angakhudze chitetezo ndi kugwiranso ntchito. Musaiwale za malangizo a madotolo, kudzipereka nokha kungawononge thanzi lanu, chifukwa chake onani dokotala wanu musanagwiritse ntchito mankhwala.
Malangizo a Metformin-Teva
Zotsatira za pharmacological
Metformin imalepheretsa gluconeogenesis m'chiwindi, amachepetsa kuyamwa kwa m'matumbo, imakulitsa kugwiritsidwa ntchito kwa glucose, komanso kumakulitsa chidwi cha minofu kulowa insulin. Sichikukhudzana ndi kubisika kwa insulin ndi ma cell a beta, sikuti kumayambitsa kutengeka kwa hypoglycemic. Amachepetsa mulingo wa ma triglycerides ndi ma linoprotein otsika m'magazi. Imakhazikika kapena kuchepetsa thupi. Ili ndi fibrinolytic mwina chifukwa chokakamira minofu ya plasminogen activator inhibitor.
Pharmacokinetics
Pambuyo pakukonzekera pakamwa, metformin imatengedwa kuchokera m'mimba. Bioavailability mutatenga muyezo mlingo 50-60%. Cmax mu madzi a m'magazi amafikira maola 2,5 atatha kumwa. Sizikugwirizana ndi mapuloteni a plasma. Amadziunjikira tiziwalo tating'ono, minofu, chiwindi ndi impso. Imayatsidwa osasinthika ndi impso. T1 / 2 ndi maola 9-12. Ndi vuto laimpso, kuwonongeka kwa mankhwalawa ndikotheka.
Zizindikiro
- matenda a shuga a mellitus 2 popanda chizolowezi cha ketoacidosis (makamaka kwa odwala omwe ali ndi kunenepa kwambiri) ndi kulephera kwa chithandizo cha mankhwala,
- kuphatikiza ndi insulin - mtundu wachiwiri wa matenda ashuga, makamaka ndi kunenepa kwambiri, limodzi ndi insulin.
Mlingo
Mlingo wa mankhwalawa umakhazikitsidwa ndi adokotala payekha, kutengera kuchuluka kwa shuga m'magazi.
Mlingo woyambirira ndi 500-1000 mg / tsiku (mapiritsi a 1-2). Pambuyo masiku 10-15, kuwonjezereka kwapang'onopang'ono kwa mlingo kumatheka kutengera mtundu wa shuga.
Mankhwala okonza mankhwalawa nthawi zambiri amakhala 1500-2000 mg / tsiku. (3-4 tabu.) Mulingo woyenera ndi 3000 mg / tsiku (mapiritsi 6).
Odwala okalamba, tsiku lililonse mapiritsi ake osavomerezeka sayenera kupitirira 1 mapiritsi 2.
Mapiritsi a Metformin amayenera kumwa nthawi zonse mukatha kudya ndi madzi pang'ono (kapu yamadzi). Kuti muchepetse mavuto kuchokera m'matumbo am'mimba, mlingo wa tsiku ndi tsiku uyenera kugawidwa mu Mlingo wa 2-3.
Chifukwa chowonjezera chiopsezo cha lactic acidosis, mlingo uyenera kuchepetsedwa ngati mavuto azovuta a metabolic.
Zotsatira zoyipa
Kuchokera pamimba: kukhumudwa, kusanza, kulawa kwazitsulo mkamwa, kusowa chilakolako cha chakudya, kutsegula m'mimba, kuwawa, kupweteka kwam'mimba. Zizindikirozi ndizofala kumayambiriro kwa chithandizo ndipo nthawi zambiri zimakhala zokha. Zizindikiro izi zitha kuchepetsa kuikidwa kwa anthocides, zotumphukira za atropine kapena antispasmodics.
Kuchokera kumbali ya kagayidwe: kawirikawiri - lactic acidosis (imafuna kuleka kwa chithandizo), ndi chithandizo cha nthawi yayitali - hypovitaminosis B12 (malabsorption).
Kuchokera ku ziwalo za hemopoietic: Nthawi zina - megaloblastic anemia.
Kuchokera ku endocrine system: hypoglycemia.
Thupi lawo siligwirizana: zotupa pakhungu.
Contraindication
- matenda ashuga ketoacidosis, matenda a shuga, chikomokere,
- kuwonongeka kwaimpso,
- Matenda owopsa omwe amabwera chifukwa cha kuwonongeka kwa impso: kuchepa magazi (ndi m'mimba, kusanza), kutentha thupi, matenda opatsirana, hypoxia (mantha, sepsis, matenda a impso, matenda a bronchopulmonary),
- mawonetseredwe azaumoyo a matenda owopsa komanso osachiritsika omwe angayambitse kukula kwa minofu hypoxia (mtima kapena kupuma, kulephera kwakumaso kwa myocardial),
- opaleshoni yayikulu ndikuvulaza (pamene chithandizo cha insulin chikusonyezedwa),
- chiwindi ntchito,
- uchidakwa wambiri, chakumwa choledzeretsa chachikulu,
- gwiritsani ntchito kwa masiku osachepera a 2 musanadutse masiku awiri mutapanga maphunziro a radioisotope kapena x-ray ndikumayambitsa ayodini wokhala ndi zosiyana pakati,
- lactic acidosis (kuphatikizapo mbiri),
- kutsatira zakudya zochepa zopatsa mphamvu (zosakwana 1000 cal / tsiku),
- mimba
- nthawi yoyambira,
- Hypersensitivity mankhwala.
Sitikulimbikitsidwa kugwiritsa ntchito mankhwalawa mwa anthu opitirira zaka 60 omwe amagwira ntchito zolimbitsa thupi, zomwe zimagwirizanitsidwa ndi chiwopsezo chokhala ndi lactic acidosis mwa iwo.
Mimba komanso kuyamwa
Pokonzekera kutenga pakati, komanso ngati muli ndi pakati mukamamwa Metformin, iyenera kuthetsedwa ndipo mankhwala a insulin ayenera kuyikidwa. Popeza palibe chidziwitso pakulowera mkaka wa m'mawere, mankhwalawa amatsutsana pakuyamwa. Ngati pakufunika kugwiritsa ntchito Metformip panthawi yoyamwitsa, kuyamwitsa kuyenera kuyimitsidwa.
Malangizo apadera
Pa chithandizo, ndikofunikira kuwunika ntchito yaimpso. Osachepera 2 pachaka, komanso maonekedwe a myalgia, zomwe zimakhala mu plasma ziyenera kutsimikiziridwa. Kuphatikiza apo, kamodzi pa miyezi isanu ndi umodzi ndikofunikira kuti muwongolere kuchuluka kwa creatinine mu seramu yamagazi (makamaka mwa odwala okalamba). Metformin sayenera kufotokozedwa ngati mulingo wa creatinine m'magazi ndiwoposa 135 μmol / L mwa amuna ndi 110 μmol / L mwa akazi.
Mwinanso kugwiritsa ntchito mankhwala a Metformin osakanikirana ndi mankhwala a sulfonylurea. Potere, makamaka kuyang'anira kuchuluka kwa shuga m'magazi ndikofunikira.
Maola 48 isanakwane komanso mkati mwa maola 48 mutatha radiopaque (urography, iv angiography), muyenera kusiya kutenga Metformin.
Ngati wodwala ali ndi matenda a bronchopulmonary kapena matenda opatsirana a genitourinary, adokotala ayenera kudziwitsidwa nthawi yomweyo.
Pa chithandizo, muyenera kupewa kumwa mowa ndi mankhwala okhala ndi Mowa. .
Kukopa pa kuyendetsa magalimoto ndi kayendedwe kazinthu
Kugwiritsa ntchito mankhwalawa monotherapy sikukhudza kuyendetsa magalimoto ndikugwira ntchito ndi njira.
Metformin ikaphatikizika ndi ma othandizira ena a hypoglycemic (sulfonylurea, insulin), mikhalidwe ya hypoglycemic imatha kukhala ndi kuthekera kochita kuyendetsa magalimoto ndi kuchita zina zomwe zingakhale zowopsa zomwe zimafunikira chidwi chochulukirapo komanso kusintha kwa ma psychomotor.
Bongo
Ndi bongo wa Metformin, lactic acidosis yokhala ndi zotsatira zakupha ndiyotheka. Zomwe zimayambitsa kukula kwa lactic acidosis amathanso kukhala cumulation wa mankhwalawa chifukwa cha kuwonongeka kwa impso.
Zizindikiro za lactic acidosis: nseru, kusanza, kutsegula m'mimba, kutsitsa kutentha kwa thupi, kupweteka kwam'mimba, kupweteka kwa minofu, mtsogolomo pakhoza kuwonjezeka kupuma, chizungulire, chikumbumtima chodwala komanso kukula kwa chikomokere.
Chithandizo : Zizindikiro za lactic acidosis, chithandizo ndi Metformin ziyenera kuyimitsidwa nthawi yomweyo, wodwalayo ayenera kuchipatala mwachangu ndipo atatsimikiza kuti ali ndi lactate, atsimikizireni matendawa. Njira yothandiza kwambiri yochotsa lactate ndi metformin kuchokera mthupi ndi hemodialysis. Chithandizo cha Zizindikiro zimachitidwanso.
Mankhwala ophatikizidwa ndi Metformin ndi sulfonylureas, hypoglycemia imayamba.
Kuyanjana kwa mankhwala osokoneza bongo
Kugwiritsa ntchito nthawi yomweyo danazol osavomerezeka kuti apewe hyperglycemic zotsatira za chomaliza. Ngati mankhwala a danazol akufunika ndipo atayimitsa koyamba, kusintha kwa ayodini wa metformin kumafunikira kuti azitha kuyendetsa glycemia.
Kuphatikiza komwe kumafunikira chisamaliro chapadera: chlorpromazine - pamene imwedwa mu milingo yayikulu (100 mg / tsiku) kumakulitsa glycemia, kuchepetsa kutulutsa kwa insulin.
Mankhwalawa antipsychotic ndipo atasiya kuyimilira, kusintha kwa metformin kumafunika muulamuliro wa glycemia.
Pogwiritsa ntchito munthawi yomweyo ndimomwe zimachokera ku sulfonylurea, acarbose, insulin, NSAIDs, ma inhibitors a MAO, oxytetracycline, ACE inhibitors, clofibrate zotumphukira, cyclophosphamide, β-blockers, ndizotheka kuwonjezera mphamvu ya hypoglycemic ya metformin.
Pogwiritsa ntchito munthawi yomweyo ndi GCS, kulera pakamwa, epinephrine, sympathomimetics, glucagon, mahomoni a chithokomiro, thiazide ndi loop diuretics, zotumphukira zochokera mu mtima, zotuluka za nicotinic acid, kuchepa kwa mphamvu ya hypoglycemic ya metformin ndikotheka.
Cimetidine amachepetsa kuchotsedwa kwa metformin, yomwe imawonjezera chiopsezo cha lactic acidosis.
Metformin itha kufooketsa mphamvu ya ma anticoagulants (zotumphukira za coumarin).
Kumwa mowa mwauchidakwa kumawonjezera mwayi wokhala ndi lactic acidosis panthawi yoledzera ya pachimake, makamaka ngati akusala kapena kutsatira zakudya zochepa zopatsa mphamvu, komanso ngati chiwindi chikulephera.
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