Glibenclamide mapiritsi analogue
Hypoglycemia (kuphwanya malamulo a dosing ndi kudya kosakwanira), kunenepa kwambiri, kutentha thupi, kutupa kwa khungu, matupi ake oyipa (zotupa pakhungu, kuyabwa), dyspepsia (nseru, kutsegula m'mimba, kumva kwambiri mu epigastrium), matenda amitsempha yama mtima , hemopoiesis (hypoplastic kapena hemolytic anemia, leukopenia, agranulocytosis, pancytopenia, eosinophilia, thrombocytopenia), chiwindi ntchito (cholestasis), mochedwa cutaneous porphyria, kusintha kwa kukoma, polyuria, chithunzi ensibilizatsiya, kupweteka kwa mutu, kutopa, kufooka, chizungulire.
Ntchito ndi mlingo
Mlingo umatengera zaka, kuopsa kwa njira ya matenda ashuga, kuchuluka kwa shuga m'magazi ndi maola awiri mutatha kudya. Wapakati tsiku lililonse mlingo kuyambira 2,5 mpaka 15 mg. Pafupipafupi makonzedwe ake ndi katatu pa tsiku kwa mphindi 20-30 musanadye. Mlingo wa zopitilira 15 mg / tsiku usakulitse zovuta za hypoglycemic. Mlingo woyamba mwa odwala okalamba ndi 1 mg / tsiku.
Posintha mankhwala a hypoglycemic ndi mtundu wofananawo, glibenclamide imayikidwa malinga ndi chiwembu pamwambapa, ndipo mankhwala am'mbuyowo amathetsedwa nthawi yomweyo. Mukamasintha kuchokera ku Biguanides, mlingo woyambirira wa tsiku ndi tsiku ndi 2,5 mg, ngati kuli kotheka, mlingo wa tsiku ndi tsiku umakulitsidwa tsiku lililonse la 5-6 ndi 2,5 mg mpaka kulipiridwa. Popeza kulibe chindapusa mkati mwa masabata a 4-6, ndikofunikira kusankha pazamankhwala omwe amaphatikiza.
Malangizo apadera
Ndikofunikira kuyang'anira kuchuluka kwa shuga m'magazi pamimba yopanda kanthu ndikatha kudya, kupindika kwa tsiku ndi tsiku m'magazi ndi mkodzo.
Pankhani ya chithandizo cha opaleshoni kapena kuwonongeka kwa matenda ashuga, mwayi wogwiritsa ntchito insulin uyenera kuganiziridwanso.
Odwala ayenera kuchenjezedwa za chiwopsezo chowonjezereka cha hypoglycemia pazochitika za ethanol (kuphatikizapo kukula kwa disulfiram-like): kupweteka kwam'mimba, nseru, kusanza, kupweteka mutu, NSAIDs, ndi njala.
Pa chithandizo, sikulimbikitsidwa kuti mukhale padzuwa nthawi yayitali.
Kusintha kwa mlingo ndikofunikira pakulimbitsa thupi ndi malingaliro, kusintha zakudya.
Mawonetseredwe azachipatala a hypoglycemia amatha kutsekedwa mukatenga beta-blockers, clonidine, reserpine, guanethidine.
Munthawi ya chithandizo, chisamaliro chikuyenera kuchitika poyendetsa magalimoto ndi kuchita zina zomwe zingakhale zoopsa zomwe zimafunikira chidwi chochulukirapo komanso kuthamanga kwa zochitika zama psychomotor.
Kuchita
ACE inhibitors (Captopril, enalapril), H2-histamine receptor blockers (cimetidine), mankhwala antifungal (miconazole, fluconazole), NSAIDs (phenylbutazone, azapropazone, oxyphenbutazone), fibrate (clofibrate, anti-agonamous) anti-agonamides mndandanda, anabolic steroids, beta-blockers, mao inhibitors, yaitali akuchita sulfonamides, cyclophosphamides, biguanides, chloramphenicol, fenfluramine, acarbose, fluoxetine, guanethidine, pentoxifylline, tetracycline, theophylline, tubule blockers o katulutsidwe, reserpine, bromocriptine, disopyramide, pyridoxine, insulin, allopurinol patsogolo zotsatira.
Barbiturates, corticosteroids, adrenostimulants (epinephrine, clonidine), antiepileptic mankhwala (phenytoin), BMKK, carbonic anhydrase inhibitors (acetazolamide), thiazide diuretics, chlortalidone, furosemide, triamterene isinazinazinazinazinazinazinazinazin. salbutamol, terbutaline, glucagon, rifampicin, mahomoni a chithokomiro, mchere wa Li +, muyezo waukulu - nicotinic acid, chlorpromazine, njira zakulera za pakamwa komanso estrogens.
Kukulitsa mankhwala a mkodzo (ammonium chloride, CaCl2, ascorbic acid mumadontho akuluakulu) kumathandizira zotsatira zake mwakuchepetsa gawo la kudzipatula ndikuwonjezera kubwezeretsanso kwa glibenclamide.
Mankhwala omwe amalepheretsa mafupa a hematopoiesis kuonjezera chiopsezo cha myelosuppression.
Katswiri wa matenda ashuga: "kukhazikika pamlingo wamagazi."
Mndandanda wa mankhwala Glibenclamide
Analogue ndiokwera mtengo kwambiri kuchokera ku ma ruble 145.
Wopanga: Dzuwa (Russia)
Kutulutsa Mafomu:
- Tab. 2 mg, ma 30 ma PC., Mtengo kuchokera ku ma ruble 191
- Tab. 3 mg, ma PC 30., Mtengo kuchokera 272 ma ruble
Malangizo ogwiritsira ntchito
Glimepiride ndi mankhwala apakhomo pochizira matenda amishuga a 2. Amapezeka mu mawonekedwe a mapiritsi okhala ndi zinthu zomwezi mu gawo la 2 mpaka 4 mg pa piritsi.
Analogue ndiokwera mtengo kwambiri kuchokera ku ma ruble 82.
Wopanga: Ikufotokozedwa
Kutulutsa Mafomu:
- Tab. ndi MV 30 mg, ma PC 30., Mtengo kuchokera ku ma ruble a 128
- Tab. 3 mg, ma PC 30., Mtengo kuchokera 272 ma ruble
Malangizo ogwiritsira ntchito
Diabetesalong ndi piritsi yothandiza mankhwalawa mtundu wa matenda a shuga 2 ochokera ku gliclazide wokwanira 30 mg. Mankhwala ndi mankhwala osakwanira olimbitsa thupi ndi kudya. Pali contraindication ndi mavuto.
Analogue ndiokwera mtengo kwambiri kuchokera ku ma ruble 73.
Wopanga: Akrikhin (Russia)
Kutulutsa Mafomu:
- Mapiritsi 80 mg, 60 ma PC., Mtengo kuchokera ku ma ruble 119
- Tab. 3 mg, ma PC 30., Mtengo kuchokera 272 ma ruble
Malangizo ogwiritsira ntchito
Glidiab ndi amodzi mwamalo opindulitsa kwambiri a gliclazide. Imapezekanso m'mapiritsi, koma mulingo wa DV ndiwambiri apa, womwe uyenera kukumbukiridwa musanayambe chithandizo. Amawonetsera matenda a shuga a 2 omwe samatha kudya komanso kuchita masewera olimbitsa thupi.
Analogue ndiokwera mtengo kwambiri kuchokera ku ma ruble 83.
Wopanga: Farmakor (Russia)
Kutulutsa Mafomu:
- Mapiritsi 30 mg, 60 ma PC., Mtengo kuchokera 129 ma ruble
- Tab. 3 mg, ma PC 30., Mtengo kuchokera 272 ma ruble
Malangizo ogwiritsira ntchito
Akrikhin (Russia) Glidiab ndi amodzi mwamalo opindulitsa kwambiri a gliclazide. Imapezekanso m'mapiritsi, koma mulingo wa DV ndiwambiri apa, womwe uyenera kukumbukiridwa musanayambe chithandizo. Amawonetsera matenda a shuga a 2 omwe samatha kudya komanso kuchita masewera olimbitsa thupi.
Analogue ndiokwera mtengo kwambiri kuchokera ku ma ruble 81.
Wopanga: Ikufotokozedwa
Kutulutsa Mafomu:
- Mapiritsi 30 mg, 60 ma PC., Mtengo kuchokera ku ma ruble 127
- Tab. 3 mg, ma PC 30., Mtengo kuchokera 272 ma ruble
Malangizo ogwiritsira ntchito
Gliclazide MV ndi piritsi lokonzekera mankhwalawa mtundu wa matenda a shuga 2 chifukwa cha zomwe zimagwiritsidwa ntchito mu 30 mg. Amawerengedwa kuti asamadye zakudya zolimbitsa thupi komanso azilimbitsa thupi. Gliclazide MV imapikisidwa kwa odwala omwe ali ndi matenda a shuga 1 (omwe amadalira insulin).
Analogue ndiokwera mtengo kwambiri kuchokera ku ma ruble 263.
Wopanga: Sanofi-Aventis S.p.A. (Italy)
Kutulutsa Mafomu:
- Tab. 1 mg, ma PC 30., Mtengo kuchokera ku 309 rubles
- Tab. 2 mg, ma PC 30., Mtengo kuchokera ku ma ruble 539
Malangizo ogwiritsira ntchito
Amaryl ndimankhwala amtundu wa shuga wachiwiri mwanjira ya mapiritsi ofunikira kugwiritsidwa ntchito kwamkati. Monga yogwira mankhwala, glimepiride imagwiritsidwa ntchito pa 1 mpaka 4 mg. Pali contraindication ndi mavuto.
Analogue ndiokwera mtengo kwambiri kuchokera ku ma ruble 93.
Wopanga: Berlin-Chemie / Menarini Pharma (Germany)
Kutulutsa Mafomu:
- Mapiritsi a 5 mg, ma PC 58., Mtengo kuchokera ku ma ruble 139
- Tab. 2 mg, ma PC 30., Mtengo kuchokera ku ma ruble 539
Malangizo ogwiritsira ntchito
Piritsi yothandizira mankhwalawa matenda a shuga yochokera ku glibenclamide (mu mawonekedwe a micron) mu muyeso wa 1.75 mg. Amawonetsedwa kuti agwiritse ntchito mtundu wa 2 matenda a shuga (ndi kusagwira ntchito mosamalitsa m'thupi).
Analogue ndiokwera mtengo kwambiri kuchokera ku ma ruble 140.
Wopanga: Canonpharma (Russia)
Kutulutsa Mafomu:
- Tab. 2 mg, 30 ma PC., Mtengo kuchokera ku 186 rubles
- Tab. 4 mg, ma 30 ma PC., Mtengo kuchokera ku ma ruble 252
Malangizo ogwiritsira ntchito
Glimepiride Canon ndi imodzi mwamankhwala opindulitsa kwambiri pochiza matenda a shuga 2 omwe amachokera ku glimepiride chimodzimodzi. Amawonetsera kusagwira bwino kwa zakudya komanso zolimbitsa thupi.
Analogue ndiokwera mtengo kwambiri kuchokera ku ma ruble 164.
Wopanga: Akrikhin (Russia)
Kutulutsa Mafomu:
- Tab. 1 mg, ma PC 30., Mtengo kuchokera ku ma ruble 210
- Tab. 2 mg, ma PC 30., Mtengo kuchokera ku 319 rubles
Malangizo ogwiritsira ntchito
Canonpharma (Russia) Glimepiride Canon ndi imodzi mwamankhwala opindulitsa kwambiri pochizira matenda amishuga a 2 omwe amachokera pa glimepiride chimodzimodzi. Amawonetsera kusagwira bwino kwa zakudya komanso zolimbitsa thupi.
Analogue ndiokwera mtengo kwambiri kuchokera ku ma ruble 256.
Wopanga: Krka (Slovenia)
Kutulutsa Mafomu:
- Mapiritsi 60 mg, 30 ma PC., Mtengo kuchokera 302 rubles
- Tab. 2 mg, ma PC 30., Mtengo kuchokera ku 319 rubles
Malangizo ogwiritsira ntchito
Kukonzekera kwa piritsi la ku Slovenia zochizira matenda amitundu iwiri. Monga yogwira mankhwala, gliclazide imagwiritsidwa ntchito mu 30 kapena 60 mg piritsi limodzi. Pali contraindication ndi zotheka zoyipa.
Analogue ndiokwera mtengo kwambiri kuchokera ku ma ruble 350.
Wopanga: Beringer Ingelheim International GmbH (Germany)
Kutulutsa Mafomu:
- Tab. 30 mg, 60 ma PC., Mtengo kuchokera ku 396 rubles
- Tab. 2 mg, ma PC 30., Mtengo kuchokera ku 319 rubles
Malangizo ogwiritsira ntchito
Glurenorm ndi piritsi yokonzekera mankhwalawa a mtundu 2 matenda a shuga ochokera glycidone mu gawo la 30 mg. Contraindicated a mtundu 1 matenda a shuga, mkaka wa m'mawere, pakati, chiwindi ndi impso. Mndandanda wathunthu wa contraindication ukhoza kupezeka mu malangizo.
Kuphatikizika, kunyamula, mawonekedwe omasulira
Kodi mankhwalawa "Glibenclamide" amapangidwa kuti? Bukuli likuti malondawa amapezeka mwanjira ya mapiritsi omwe amaikidwa mu zotengera za pulasitiki (ma contour cell) ndi makatoni a makatoni, motsatana.
Kapangidwe kamankhwala komwe kamafunsidwa kamaphatikizapo 5 mg ya glibenclamide, komanso zothandizira zina monga mbatata wowuma, lactose monohydrate, magnesium stearate, croscarmellose sodium, indigo carmine E 132, colloidal silicon dioxide ndi povidone 25.
Zochita zamankhwala
Kodi mankhwalawa "Glibenclamide" ndi ati? Malangizo ogwiritsira ntchito akuti izi ndi zotsatira za hypoglycemic mwa anthu athanzi komanso odwala omwe ali ndi matenda a shuga a 2.
Kuchita bwino kwa mankhwalawa kumatheka chifukwa chakuchulukitsa kwake kwa insulin chifukwa cha maselo a beta chifukwa cha kukondoweza kwawo. Malinga ndi akatswiri, izi zimapangitsa kuti mankhwalawa akhale ndi shuga.
Kinetic mawonekedwe amkamwa
Ndi mankhwala ati a pharmacokinetic omwe amadziwika ndi mankhwala a Glibenclamide? Malangizo ogwiritsira ntchito akuti pakadutsa pakamwa pakumwa mapiritsi, mphamvu yake yogwira ntchito imathamanga ndipo imatsala pang'onopang'ono kuchokera m'mimba.
Kugwiritsa ntchito nthawi yomweyo kumabweretsa kuchepa kwa kuchuluka kwa glibenclamide m'madzi a m'magazi (poyerekeza ndi kusala kudya). Kulumikizidwa kwa chinthuchi ndi albin ndi zoposa 98%.
Mu chiwindi cha wodwalayo, glibenclamide imasinthidwa kukhala ma metabolites otsatirawa: 3-cis-hydroxy-glibenclamide ndi 4-trans-hydroxy-glibenclamide. Amatulutsidwa chimodzimodzi kudzera mu impso ndi ndowe.
Pafupifupi mankhwala theka moyo ndi 2-3 ndi maola. Mwa anthu omwe ali ndi vuto la chiwindi, chiwonetserochi chimachepetsedwa kwambiri.
Zoletsa kugwiritsa ntchito
Kodi pali zotsutsana ndi Glibenclamide? Malangizo ogwiritsa ntchito akuti chida ichi sichiyenera kuperekedwa kwa odwala omwe ali ndi:
- kuwotcha kwakukulu
- Hypersensitivity yogwira pophika, komanso thiazide diuretics kapena sulfonamides,
- ketoacidosis,
- diabetic comatose komanso mikhalidwe yabwino,
- kukula kwa hypoglycemia,
- kuchitapo kanthu kwa opaleshoni ndi kuvulala kwina,
- paresis yam'mimba komanso m'matumbo,
- mimba
- mtundu 1 shuga
- yoyamwitsa.
Mankhwala "Glibenclamide": malangizo ogwiritsira ntchito
Mankhwala omwe akufunsidwa ayenera kuperekedwa ndi dokotala wodziwa ntchito. Kumwa mankhwalawa nthawi zonse kumayenera kuphatikizidwa ndi chakudya chokhwima. Pokhapokha pamenepa ndi pomwe zingakhale zothandiza. Rimage regimen imatengera zotsatira za kuwunika kwa wodwalayo (shuga wamagazi, zizindikiro zomwe zimapezeka chifukwa cha mayeso a mkodzo, etc.).
Ndiye muyenera kumwa bwanji mankhwala "Glibenclamide"? Chithandizo cha chida ichi chimayamba ndi Mlingo wochepa. Izi ndizowona makamaka kwa anthu omwe ali ndi vuto la hypoglycemia ndi kulemera kwa thupi zosakwana 50 kg.
Nthawi zambiri, mulingo woyamba wa mankhwalawa ndi mapiritsi a 0.5-1 patsiku. Izi zikufanana ndi 2.5-5 mg wa chinthu chomwe chikugwira ntchito. Ndi phindu la mankhwalawa, kuchuluka komwe kukuwonetsedwa kumatha kuwonjezeka pang'onopang'ono mpaka mapiritsi atatu patsiku, omwe amafanana ndi 15 mg ya mankhwala othandizira. Izi zikuyenera kuchitika pakadutsa masiku angapo mpaka sabata imodzi mpaka zotsatira zomwe mukufuna zitheke.
Momwe mungasinthire wodwala kuchokera ku mankhwala ena kupita ku mankhwala a Glibenclamide? Kugwiritsa ntchito mankhwalawa pankhaniyi kuyenera kuchitika mosamala kwambiri. Choyamba, wodwalayo amapatsidwa mapiritsi 0,5 patsiku, kenako mlingo umakulitsidwa pang'ono ndi pang'ono.
Kwa okalamba, komanso odwala ofooka kapena odwala omwe ali ndi vuto losakwanira lokwanira la chiwindi kapena matenda a impso, ndikofunikira kuti achepetse kukonza kapena mlingo woyambirira wa mankhwalawa momwe angathere chifukwa cha chitukuko cha hypoglycemia. Komanso funso lofuna kusintha mlingo wa mankhwalawo liyenera kuyankhidwa pamene thupi la wodwalayo likuchepa kapena moyo wake wachikhalidwe ukasintha.
Njira yotengera mapiritsi a hypoglycemic
Kodi Glibenclamide imagwiritsidwa ntchito bwanji? Malangizo ogwiritsira ntchito (chithunzi cha mankhwalawa chikufotokozedwa m'nkhaniyi) akunena kuti mapiritsi omwe akufunsidwa ayenera kumwedwa kaye asanadye, kutsukidwa ndi kapu ya madzi osasankhidwa osasetedwa.
Ndi mlingo wa mapiritsi a 2 a tsiku lililonse, mankhwalawa amalimbikitsidwa kuti agawidwe mu 2 Mlingo (m'mawa ndi madzulo) muyezo wa 2: 1.
Ndikofunikira kugwiritsa ntchito mankhwalawa nthawi imodzi. Ngati mungadumphe kumwa mankhwalawo, piritsi sikuyenera kutengedwa ndi lotsatira.
Kutalika kwa mankhwala ndi mankhwalawa zimatengera njira yamatendawa. Munthawi yonse ya chithandizo, kuyang'anira wodwala kagayidwe kake kokwanira kumafunikira.
Zotsatira zoyipa
Mankhwala "Glibenclamide", zomwe zimafotokozedwera pansipa, zimatha kuyambitsa zovuta zomwe zimakhudza manjenje, endocrine, zotumphukira ndi zotupa, komanso hematopoietic. Pankhaniyi, wodwalayo amatha kudwala matenda monga mseru, hypoglycemia yosiyanasiyana, kusokonezeka kwa chiwindi, kutsekula m'mimba, kupweteka kwa mutu, cholestasis, kufooka, chizungulire komanso kutopa.
Tiyeneranso kudziwa kuti posachedwa pomwera mankhwalawa, maonekedwe a khungu komanso thupi lawo siligwirizana ndi mawonekedwe a photosensitivity, kuyabwa, zotupa pakhungu ndi zizindikiro zina zosasangalatsa sizimalamulidwa.
Hypoglycemic bongo
Ndi ziti zomwe zimachitika mukamamwa mankhwala waukulu "Glibenclamide"? Malangizowo akuti pogwiritsa ntchito mankhwala osokoneza bongo, wodwalayo amatha kukhala ndi hypoglycemia, mwina ndi kufooka, njala, kupweteka kwa mutu, kuda nkhawa, thukuta kwambiri, chizungulire, kunjenjemera kwa minofu, kupweteka kwa m'mimba, edema ya m'magazi, zovuta zowonera komanso zolankhula.
Chithandizo cha zotere chimaphatikizidwa ndikuyendetsa mwachangu ma glucose okhala ndi zida zopukusa m'mimba. Mwachitsanzo, msuzi wa zipatso, shuga, madzi a chimanga, tiyi wowotcha kapena uchi.
Mochulukirapo, wodwalayo amapaka jekeseni wa 50% shuga, Dextrose, Glucagon kapena Diazoxide. Kuwongolera kwapadera kwa glycemia, creatinine, urea nayitrogeni, ma elekitirodi ndi kutsimikiza kwa pH kumafunikiranso.
Zambiri
Hypoglycemic wothandiziridwa amayenera kugwiritsidwa ntchito mosamala odwala omwe ali ndi vuto laimpso komanso kwa chiwindi, komanso munjira yotupa ya chithokomiro komanso matenda a adrenal, zotupa komanso uchidakwa wambiri.
Kuti mupeze chithandizo chazovomerezeka pamafunika kuwunika pafupipafupi kuchuluka kwa shuga m'magazi a wodwalayo, komanso momwe amadzera.
Wodwala akayamba hypoglycemia pamene akumwa mankhwalawo, ndiye kuti shuga amawerengedwa mkati (ngati munthuyo akudziwa). Pofuna kutaya chikumbumtima, glucose imayendetsedwa kudzera m'mitsempha, ndipo glucagon imayang'aniridwa movomerezeka, kudzera m'mitsempha kapena m'mitsempha. Wodwalayo akayambanso kuzindikira, nthawi yomweyo amamupatsa chakudya chamagulu azakudya kuti asadzayambenso hypoglycemia.
Mtengo ndi ma analogi (ndalama)
Sankhani analogi ya mankhwalawa ayenera kukhala katswiri wodziwa bwino. Madotolo amatanthauza mankhwalawa: "Maninil", "Manin", "Maniglide", "Betanaz" ndi "Antibet".
Tiyeneranso kudziwa kuti m'mafakitala nthawi zambiri amagulitsa ma syonyms a mankhwalawa. Nthawi zambiri amagwiritsidwa ntchito monga: Glidanil, Glibex, Glibamide, Gilemal, Glibomet, Glibenclamide. Mlingo wa ndalamazi amasankhidwa payekha.
Ponena za mtengo wa mankhwalawo "Glibenclamide", umasiyana pakati pa ma ruble 280-360.
Ndemanga za Mankhwala
Tsopano mukudziwa chomwe mankhwalawo "Glibenclamide" ndi. Malangizo ogwiritsira ntchito, ma analogu ndi mawonekedwe omasulira a wothandizirawa akufotokozedwa pamwambapa.
Kodi ogula amati chiyani pamankhwala awa? Monga lamulo, malipoti onse okhudza nkhaniyi amatsikira pokambirana njira zina zochiritsira zomwe zimalimbikitsidwa kwa anthu odwala matenda ashuga.
Ogwiritsa ntchito amati nthawi zambiri amagwiritsa ntchito Glibenclamide ngati monotherapy. Ngakhale pali odwala omwe amadziwika ndi mankhwalawo kuphatikiza ndi mankhwala ena a hypoglycemic.
Malinga ndi madotolo, kuikidwa kwa mankhwalawo kukufunikira munthu aliyense payekha. Poterepa, katswiriyu ayenera kudziwa zonse zotsatira za kusanthula ndi maphunziro ena. Kutenga "Glibenclamide" kwa odwala mwakufuna kwawo kuli kowopsa kwaumoyo ndi moyo.
Pharmacological zochita za glibenclamide
Glibenclamide imakhala ndi hypocholesterolemic komanso hypoglycemic pa thupi la munthu.
Zomwe zimagwira ndi glibenclamide. Zothandiza monga lactose monohydrate, mbatata kapena wowuma chimanga, croscarmellose sodium, povidone 25, magnesium stearate, indigo carmine ndi aerosil.
Malinga ndi malangizo, Glibenclamide imakhala ndi mphamvu yolimbikitsa maselo a beta ya islet apparatus, ndipo imakhudza katemera wa pancreatic wa insulin. Zochita za mankhwala zimawonetsedwa ndikusunga insulin yopanga ntchito ya kapamba. Chidacho chimathandizira kubwezeretsa chidwi cha thupi cha ma beta kuti ziwonongeke glycemic.
Mankhwalawa amatha kutulutsa mphamvu ya insulin komanso amkati pochulukitsa insulin, zimathandizira kusintha kwa insulin-receptor mogwirizana ndi kubwezeretsanso kwa trans-receptor sign transuction.
Kuchuluka kwa plasma mu insulin ndende ndikuchepa kwa glucose sizimachitika mwachangu, koma pang'onopang'ono. Njira zoterezi zimachepetsa kwambiri chiopsezo cha mikhalidwe ya hypoglycemic.
Kugwiritsa ntchito glibenclamide kumakhala ndi zotsatira zabwino pakukulitsa chidwi cha insulin receptors ku insulin mu zotumphukira zimakhala, zomwe zimapangitsa zotsatira zowonjezera-pancreatic. Komanso, chifukwa cha zomwe zimapangidwira pokonzekera, kugwiritsidwa ntchito kwa glucose mu minofu ndi chiwindi kumakulitsidwa, mapangidwe a glycogen amalimbikitsidwa mwa iwo (kutulutsa kwa glucose kuchokera ku chiwindi kumachepetsedwa). Mankhwalawa ali ndi hypolipidemic komanso antidiuretic kwenikweni, amathandiza kuchepetsa mphamvu za magazi m'magazi, amalepheretsa kuchitika kwa arrhythmias.
Mphamvu ya mankhwalawa imawonekera patatha maola awiri mutangoyendetsa, imafika pakatha maola 8, ndipo zotsatira zake zimakhala mpaka maola khumi ndi awiri.
Glibenclamide imatengedwa mwachangu komanso kwathunthu kuchokera kumatumbo. Pambuyo pakulowetsa, imasinthidwa kukhala ma metabolites ofanana ofanana, amodzi amachotseredwa mkodzo, ndipo chachiwiri ndi bile kuchokera m'mimba.
Njira zogwiritsira ntchito Glibenclamide ndi mlingo
Glibenclamide imatengedwa pakumwa pambuyo chakudya kamodzi kapena kawiri pa tsiku. Mlingo wa mankhwalawa amatchulidwa ndi dokotala aliyense payekha, kutengera kuopsa kwa matendawa. Yambani mankhwala ndi 2,5 - 5.0 - 10,0 mg patsiku. Mlingo wa glucose m'magazi utasinthika, mankhwalawa amatha kukhala olingana ndi 5.0 - 7.5 mg patsiku.
Ngati pakadutsa masabata asanu ndi limodzi mlingo wa 20 mg wa mankhwalawa suwapatsa mankhwala, mankhwalawo sagwira ntchito mokwanira kwa wodwala. Poterepa, Glibenclamide ikhoza kuphatikizidwa ndi analogues kapena biguanides. Ngati kuphatikiza uku sikuthandizira, ndikofunikira kupereka mankhwala a insulin.
Ngati kusintha kwapangidwa kuchokera ku mankhwala ena omwe amachepetsa shuga, tsiku lililonse mlingo wa 2.5 mg umayikidwa. Ngati ndi kotheka, imakula masiku onse asanu ndi 2 mg mpaka chiphuphu chikwaniridwe. Mlingo waukulu kwambiri ndi 20 mg.
Kukhazikitsidwa kwa Glibenclamide nthawi imodzi ndi butadione, Mao inhibitors, ndi zotumphukira za coumarin sikulimbikitsidwa. Chenjezo liyenera kuchitika pakukhazikitsa mankhwalawa limodzi ndi anabolics, H3-histamine receptor blockers, ndi chloramphenicol.
Contraindication
Malinga ndi malangizowo, Glibenclamide sayenera kumwedwa chifukwa cha chikomokere komanso kuchepa kwa chikumbumtima, ketoacidosis, matenda aimpso ndi kwa chiwindi, leukopenia, kuwerengera kwam'magazi, komanso kuubwana ndi unyamata.
Kugwiritsa ntchito mankhwalawa azimayi pa nthawi yoyembekezera komanso mkaka wa m'mawere sikulimbikitsidwa.
