Atorvastatin: malangizo ogwiritsira ntchito ndi kuwunika kwa mtima

Sindinawonenso kusintha, koma mutu, chizungulire komanso kugona. Kodi "Botany" wathu azibwera ndi chiyani kuti athandize anthu, osati motsatana))

Anayikidwa kumwa atorvastine ndi cholesterol 6. 5. Ndimamwa 10 mg patsiku - sindikuwona ntchito yapadera, koma pali zovuta zingapo. Ndikuyesa kusinthana ndi chakudya.

Sindinganene kuti mankhwalawa ndi odabwitsa. Adalembera bambo anga pamtengo wa 60 mg / tsiku, chifukwa cholesterol yayikulu ndi chibadwa chathu.

• mwayi wolandila (mosasamala kanthu za chakudya).

• Sindinazindikire kusintha kulikonse kwaumoyo kumapeto kwa maphunziro. Momwe cholesterol imaposa 7 mmol / l, idatsalira.Ndiye miyezi isanu ndi umodzi, cholesterol ya abambo ake adatseka mtsempha wamagazi, womwe unayambitsa necrosis ya chala chachikulucho. Tsopano, pofuna kupewa kudulidwa kawiri pachaka, abambo amapangidwa ndi mankhwala okwera mtengo kwambiri.

Malingaliro anga, atorvastatin ndi mankhwala osagwira ntchito konse, ndipo sindikudziwa zomwe madokotala amatiuza.

Amayi Atorvastatin adawerengedwa pambuyo pa stroko. Izi zisanachitike, amayi anga nthawi zambiri ankamwa mapiritsi a cholesterol okwera, koma onse anali okwera mtengo, opitilira 1000r. Pankhaniyi, mtengo unakondwera. Koma iyi ndiye kuphatikiza kokha kwa amayi.

Pambuyo pa miyezi itatu ya kumwa Atorvastatin, cholesterol sinachepe. Potengera maziko akumwa mapiritsi, mutu ndi mseru ukupitilira. Ndizofunikira kudziwa kuti malangizowa ali ndi zotsatira zoyipa zingapo, kuphatikiza mankhwalawa osavomerezeka kwa okalamba. Ndipo amayi anga ndi okalamba basi. Inde, ndipo cholesterol yayikulu imakhudza gulu la anthu.

Adafunsa adotolo kuti aletse mankhwalawo, sanatilolere, anati ayenera kumwa mankhwalawo nthawi yonse, ndipo sakunena kuti. Chifukwa chake musokoneze naye. Mankhwalawa sakhala omasuka konse, ndipo palibe malingaliro kuti mankhwalawo amabweretsa kuchira.

• mavuto ambiri

Ndikufuna kukambirana za chinthu chimodzi chosasangalatsa, chokumana nacho cha cholesterol changa m'mwazi. Zinachitika kuti cholesterol yanga inali yokwera kuposa yachilendo, ndinali ndisanayesepo, ndipo amangondipeza kuchipatala.

Mwachidule, adotolo adalimbikitsa kuti achepetse, chifukwa mafuta ambiri a cholesterol, amakhala oopsa. Kutsitsa, kudya. Kusanthula kukapita, kunapezeka kuti kotsika kwambiri kuposa momwe kanakhalira. Kuti muwonjezere izi, dokotalayo adandipatsa mankhwala "Aorvastatin". Chabwino, ndikuvomereza, nthawi yamadzulo. Pambuyo pa masiku angapo atandilandira, ndimakhala ngati chinjoka chopumira moto mkati mwanga. Kupweteka kwamtima kosatha, chinthu chosamveka m'mimba.

Pambuyo pa sabata lozunzidwa, ndinali wanzeru kuti nditha kuwerengera ndemanga osati pa Otzovik wathu, nditazindikira kuti izi zikuchitika kwa ine. Inathetsa mwachangu zonse ndipo moyo unayamba kuyenda bwino. Sindinakhalepo ndi mavuto m'mimba, chifukwa chake sindingaganizire momwe mankhwalawa amalembera anthu omwe ali ndi mavuto awa.

Inde, tonse ndife osiyana, "kuti kufa ndi kwabwino kwa Russia-Germany," koma ndikuganiza kuti ngati muyenera kukhazikitsa china chake mthupi mwachilengedwe, chonde, pitilizani kudya, idyani masamba ndi zipatso, sewerani masewera.

Sindilangiza abwenzi, mapiritsi ndi "achabe".

Sindikulangizeni kuti musawagwiritse ntchito

Atorvastatin ndimatenga zaka 1, 5. Cholesterol kwenikweni sikuchepetsedwa. Zinali 4, 6 zinakhala 4, 4. Kodi ndizoyenera kulimbitsa chiwindi chanu ngati mankhwalawo sagwira ntchito. Poyamba ndidatenga 20 mg, kenako adotolo adakulitsa mlingo mpaka 30 mg.

Chiwerengero chachikulu cha zoyipa. Ndinali kugona, kulemera m'mutu mwanga, nditatha sabata kuvomereza, tsoka lidachitika: chizungulire chinakulirakulira mpaka ndinayitanira ambulansi, yomwe ndinali ndisanachitepo. Kunali kusanza, kukhathamira kwa mphamvu (ndipo sindimavutika ndi izi konse), pafupifupi kutaya chikumbumtima. Ananditengera ku 1st Gradskaya, ndikupanga ma Sc scan, mtima, komanso kuyezetsa magazi. Sanapeze cholakwika chilichonse, adazindikira kuti ali ndi matenda am'mimba ndipo anawatumiza kunyumba. Tsopano ndimawerenga malangizowo ndikupeza zizindikilo zanga mu ZIVUTSO ZAKUTI. Kodi ndingalandirebe chiyani?

Werengani buku lonse. Madokotala amachenjeza za zovuta zomwe zingachitike.

Anayesedwa ndipo adawulula cholesterol yokweza - 7, 6. Dokotala adalemba piritsi la atorvastatin 1. Patatha piritsi lachinayi, kupanikizika kunawonjezeka, ngakhale kupanikizika kwanga kumakhala koyenera. Ndidayitanitsa ambulansi. Tsopano ndidaganiza kuti ndisamwe mapiritsi awa. Ndiona ndikupita kwa dokotala kuti ndikaonane.

Mwina akuti mwatsutsa.

Ndimatenga atorvastatin masiku 5. Mutu. Phokoso m'mutu. Panali kukokana mwendo usikuuno. Mankhwala oopsa. koma cholesterol 9, 3. Dotolo adalembera. Zopanda chakudya zonse zopangidwa ndi nyama. Kumanzere nkhuku yophika yokha. Ndiona zotsatira mwezi umodzi.

Ndidakwanitsa kutenga Atorvastatin tsiku limodzi lokha, ndipo ndidakakamizidwa kukana. Mankhwalawa siali a ine, chifukwa ndili ndi matenda am'mimba komanso matenda opunduka a msana. Ndakhala ndikugwiritsa ntchito mankhwala osokoneza bongo kwa nthawi yayitali. Ndili ndi mantha kuti chithandizo ichi sichiyenera kusakanikirana ndi mankhwala anga. Tsiku lotsatira, khutu langa lakumanja linali litatsekedwa, ndinadwala mutu. Zofooka ngati izi zidandigwira mpaka tsiku limodzi ndikubwerera, ndimagona tsiku lonse.

Anandiika 40 mg wa Atorvastatin chifukwa cha ululu wamtima. Ndidapitilira

Anandiika 40 mg wa Atorvastatin chifukwa cha ululu wamtima. Ndakhala pa miyezi 9. Zidachepetsa kwenikweni cholesterol yanga, koma zidakhala ndi zoyipa zambiri zosafunikira! Nthawi yomweyo ndinazindikira kuti ndili ndi vuto lokumbukira, ndinayamba kuyiwala chilichonse, chifunga changa m'mutu mwanga. Ululu wam'mimba nawonso unayamba kuvuta. Ndipo mkazi wanga adayamba kulabadira kuti nkhawa yanga ikusokonekera, ndidakwiya kuchokera kunja, popanda chifukwa.

Ndemanga zopanda ndale

Sindinathandizenso ndipo panali zovuta zina. Sungunulani zakudya zowonjezera: Kukana soseji, mazira, tchizi ndi batala. Komanso kuphika. Pambuyo pa miyezi iwiri sindinachepetse thupi, koma cholesterol idakula bwinobwino

Inali 7.1, atatenga kukhala 7.2

Mankhwalawa ndi abwino, ngakhale m'masabata awiri oyambapo panali mseru pang'ono, kenako adadutsa. Atakhutira ndi mankhwalawo, cholesterol imabwerera mwachangu 10.3-5.1. Posachedwa, mnzake ngozi (atherosulinosis) adati adamulembera rosuvastatin-sz, komanso statin, koma zikuwoneka kuti yatsopano yamakono ili ndi zotsatirapo zochepa. Sindikudziwa ngati pakufunika kusintha mankhwalawa, chifukwa nseru sichidanso nkhawa.

Atorvastatin ndi mankhwala othandiza omwe agwiritsidwa ntchito kwa nthawi yayitali. Chokhacho chomwe chikufotokozedwa tsopano ndi m'badwo watsopano wama statins. Zikuwoneka kuti amakhulupirira kuti zoyipa zoyambira ndizochepa. Atorvastatin amafananizidwa pamtengo ndi rosuvastatin-sz, koma chomaliza ndi chamakono kwambiri.

Moona mtima sindinazindikire kusiyana pakati pa atorvastatin ndi rosuvastatin. Ndidatenga atorvastatin kwa miyezi 4, cholesterol yabwerera mwachizolowezi, pomwepo dotolo adati rosuvastatin-sz - cholesterol imakhalanso, ndimamva bwino. Ndikukhulupirira kuti mankhwala atsopano akadali abwino.

Ndinatenga maphunziro a atorvastatin 2, amatsitsa cholesterol bwino, ndinali wopanda vuto ndi chizungulire, apo ayi zonse zinali zodabwitsa. Kenako, mogwirizana ndi dokotala, anasinthana ndi rosuvastatin-sz, uno ndi m'badwo wotsatira wama statins. Palibe zoyipa, komanso zoyenera.

Ubwino: Mankhwalawa amatha kugwiritsidwa ntchito kwa nthawi yayitali, pamtengo wotsika.

Zoyipa: Mankhwalawa amayenera kugwiritsidwa ntchito ndi analgesic, popeza atatha kutenga mutu umawoneka.

Ndakhala ndikugwiritsa ntchito mankhwalawa kwa nthawi yayitali, mumtengo wotsika, chifukwa zomwe mafuta amafuta a cholesterol amachepetsa pang'onopang'ono. Muyenera kutenga ndi analgesic, chifukwa mutatha kutenga, mutu umatuluka. Dokotala adalamulira kuti amwe mankhwalawo usiku. Chifukwa chake, kupita kukagona, ndimatenga ndi analgesic.

Atorvastatin - mankhwala ochepetsa cholesterol

Chapakatikati, ndikadali tchuthi chodwala ndi matenda opatsirana pachimake, ndidakumana ndi mayeso kuchipatala, chifukwa chake, ngati odwala onse azaka zanga zobadwa, ndimayenera kukayezetsa (FLG, mayeso, ultrasound, mammography, ndi zina). Wochiritsayo adapereka chiyembekezo pazotsatira zonse. Mu mayeso anga a biochemical magazi adawonetsa kuchuluka kwa cholesterol, triglycerides ndi china chake pamenepo. Amayi anga anali ndi myocardial infarction, ndili ndi matenda oopsa, motero adotolo, akuti ndili m'gulu lowopsa lachitukuko cha IHD ndi vuto la mtima, adandiwuza mapiritsi a Atorvastatin 20 mg 1/2 t. kamodzi patsiku. Kuphatikiza apo, adotolo adandiuza mosamala kuti ndizitsatira zakudya. Patatha mwezi kuchokera chiyambi cha chithandizo, ndidapimanso kuyesanso magazi. Dokotala sanakhutire ndi izi ndikuwonjezera pa piritsi limodzi. Anandichitira mwezi wina. Pomaliza, chithandizo chomwe chimapereka zotsatira, cholesterol inachepa kwambiri. Ndikupitilizabe kumwa Atorvastatin mtsogolo.

Ndinawerenga malangizowo - Mulungu wanga, mankhwalawa angathe kukhala ndi mavuto ambiri bwanji! Ndipo adotolo adati ndichitenga pano kwa nthawi yayitali, sindingapewe zotsatirapo zake. Koma pakali pano sindikuwoneka kuti ndikuzindikira chilichonse.

Mankhwala abwino. Koma akatswiri odziwa za mtima akuwalangizidwa kuti azisanthula pamaziko a zopweteka. Zosokoneza chiwindi. Musaiwale kuti ma statins amachotsa cholesterol yoyipa komanso yabwino m'thupi.

Palibe vuto kwa chiwindi. Musanayambe kumwa ma statins (mankhwala omwe amachepetsa cholesterol yamagazi) muyenera kusintha moyo wanu, kusinkhasinkhanso zakudya zanu, ndipo pokhapokha ngati theka la chaka, cholesterol siyibwerera mwakale, ndiye kuti muyambe kumwa Atorvastatin.

Mwamuna wake adalembetsa kale hypercholesterolemia ndi hyperlipidemia poyesa magazi kwa biochemical kwazaka zingapo. Zakudyazo sizipereka phindu lililonse, ngakhale pakusala, tikakana nyama, cholesterol sikucheperachepera. Dokotala adamupatsa mankhwala Atorvastatin 10 mg kamodzi patsiku. Amayamba kudya, patatha milungu iwiri panali kusinthaku, patatha mwezi umodzi cholesterol idalowa malire apamwamba.

Mphamvu yogwiritsira ntchito mankhwalawa ndi yovuta kwambiri, choyamba imasokoneza kaphatikizidwe ka cholesterol, ndipo chachiwiri chimakulitsa mulingo wa zolandilira cell kupita ku cholesterol, zomwe zimapangitsa kuti zigwiritsidwe mwachangu kwambiri mu cell.

Mankhwalawa ndi otsika mtengo kwa maphunziro a pamwezi - pafupifupi ma ruble 350. Mutha kumwa piritsi mosasamala chakudyacho, ndiye chosavuta, popeza mumayiwala kumwa mankhwala ambiri pamimba yopanda kanthu kenako kudikirira theka la tsiku mukatha kumwa. Mankhwala atayamba, mwamunayo adakhala ndi mavuto. Kupanga kwake kwasintha, michere ya hepatic yadumpha pang'ono, ali ndi kufooka, mutu. Pambuyo pake zonse zidapita, ngakhale mafutawo a chiwindi sanachepe mpaka mankhwala atatheratu. Anamwa Atorvastatin kwa miyezi iwiri.

Pazonse, mankhwalawa ndiabwino, samathandiza, ngakhale kuti sangachite popanda mavuto.

Mayankho abwino

Ndikuwerenga ndemanga ndipo ndangosokonezeka, ndimamva kuti ndili ndi nkhawa. Ndamwa mankhwalawa kwa miyezi 1.5 ndipo sindinakhalepo ndimavuto ena aliwonse. Popeza panali kuthamanga kwa magazi komanso kugunda kwa mtima, palibe. Nusea, etc., monga amanenera NO. kuyezetsa magazi kuyenera kutengedwa ndi cholystyrin kuti mudziwe, anali 6.2.. Ndipo kotero palibe mavuto azaumoyo

Mankhwala onse awiri amalimbana ndi ntchitoyo - kutsitsa cholesterol. Ine ndekha ndinatenga atorvastatin-sz, tsopano ndimatenga rosuvastatin-sz. Mwambiri, ndili ndi "chidziwitso" cha 10 pobata ma statins, mu 2009 adayika zovuta za hypercholesterolemia + zotsutsana ndi matenda a shuga. Atorvastatin-sz inatenga zaka 7, kuyambira mwezi wachiwiri wa kutenga 5.8-6.2 mavuto sanawone. Kenako, mu 2016, adandivomera rosuvastatin-sz, mankhwala a statin m'badwo wotsatira. Ndidapitilira, sindimamva kusintha kulikonse, cholesterol yanga idakhala yabwinobwino. Chifukwa chake ndikuganiza - kukoma ndi mtundu .. mwina zamakono kwambiri, mwina njira zina sizimamvetseka.

Ndimalimbikitsa kwambiri mankhwalawa. Abambo anga adatenga zaka 7, amakumbukira za cholesterol kamodzi miyezi isanu ndi umodzi, pomwe amapanga mbiri ya lipid. Tsopano akutenga rosuvastatin-sz, monga mankhwala atsopano, motero ndikusangalala kwambiri ndi izi. Inde, ndikothekera kwambiri kutero chifukwa Piritsi limodzi patsiku

Mankhwala abwino. Iyenso adatenga nthawi yayitali ndipo amuna awo nawonso adakhala bwino. Cholesterol yakhala yachilendo kwa zaka zambiri, ndizachisoni kuti mumangofunika kutenga ma statins moyo wanu wonse. mwezi wapitalo, adotolo adamuwuza kuti mwamuna wake asinthe piote yamakono ya rosuvastatin-sz. Wowoloka, cholesterol idakhala yokhazikika. Tsopano ndikuganiza, nditha kusintha mankhwalawo kapena kukhalabe pa atorvastatin?

Kodi ma statin a m'badwo woyamba komanso wachiwiri amagwiritsidwabe ntchito? Ndidangoona mibadwo itatu mu mankhwala atorvastatin - pomwe ndidamwa, ndi mankhwala abwino. Pachokha pachaka amavomereza bwino rosuvastatin-sz 4 mibadwo. Cholesterol 4.5, panalibe zotsatira zoyipa.

Mankhwala ndiwotsimikizika, adatenga zaka 5. Cholesterol sizinapite kupitilira momwe zinalili. Zaka 2 zapitazo, adasinthanitsa (chilichonse monga momwe adanenera dokotala) ndi rosuvastatin-sz, akuwoneka ngati achatsopano, zotsatira zake ndi zofanana - sindinazindikire kusiyana, koma zikugwira ntchito.

Atorvastatin aledzera ndi abambo anga, adamupatsa ntchito kuti amwe kwa moyo wonse. Cholesterol inachepa bwino, vuto linali ndi triglycerides. Dibicor adalembedwanso, ndipo triglycerides idayambanso kuchepa ndipo chiwindi chimasiya kusewera pranks, dibicor ikuwoneka kuti ikuteteza.

adatenga atorvastatin wa cholesterol yayikulu, idamuthandiza, koma mwatsoka idadwalitsa. Adafunsa adotolo kuti asankhe china, adalangiza kuyesa rosuvastatin-sz - izi zili ngati m'badwo watsopano. Ndimatenga mwezi, zonse zili mu dongosolo.

Ndikumwa atorvastatin-sz mchaka chachiwiri, cholesterol ndiyabwino, ndipo ndikuganiza kuti idandithandizira kutaya makilogalamu ochepa. Adandithandiza kwambiri, pachakudya chimodzi sindimakhala nthawi yayitali.

Atorvastatin ss adandiuza kuti ndichepetse cholesterol. Tili ndi vuto labanja ndipo ndimadziwa za izi. Ndimamwa pafupipafupi m'maphunziro, cholesterol sikumuka, sindinapeze vuto lililonse ku thanzi langa.

Aliyense amalemba kuti zakudya zimathandiza ndi cholesterol, koma sizili choncho - zidatsimikiziridwa kale kuti cholesterol yayikulu imapangidwa m'thupi lokha. Atorvastatin ndi piritsi labwino ndipo amathandizira ndi chithandizo, koma uku ndi m'badwo wam'mbuyomu wama statins, tsopano atsopano ambiri apangidwa. Ndimatenga rosuvastatin-sz - zotsatira zake ndizabwino, koma zotsatira zoyipa ndizochepa.

Sindikudziwa kuti ndinali ndi vuto la cholesterol mpaka, mwangozi, adokotala adazindikira izi. Ndinkamwa maphunziro a Atorvastatin sz ndikutsatira chakudya. Cholesterol yafupika, chifukwa chake, ndikupangira.

Pamene cholesterol yapamwamba idapezeka mu kusanthula, ndidalembedwa Atorvastatin cz. Ndinavutika kwambiri ndikamadya. Koma zidapezeka kuti ndikuchepera. Mankhwala abwino, okondwa nawo.

Atorvastatin sz waledzera ndi amayi anga. Ali ndi mavuto a cholesterol komanso matenda oopsa 2. Cholesterol imabweranso ngati yachilendo, timamwa maphunziro. Pali zotsatira zoyipa zambiri mu malangizowo, koma amayi anga sanaone chilichonse.

• Imathandizira Pansi Cholesterol

Ndinayamba chizungulire, kudumpha kwa magazi kunayamba ndipo kugundika kunali kofooka. ndipo ndinapita kwa adotolo, ndinadutsa mayeso onse, ndinachita ma ultrasound a mitsempha yaubongo ndipo adotolo anandiuza mapiritsi a otorvostatin. Ndinayamba kumwa piritsi limodzi la mamilimita 20 kamodzi patsiku nthawi yomweyo, mkhalidwe wanga unayamba kuyenda bwino, magazi anga ankadumphadumpha, ndi zina zotero. Mwezi uliwonse ndimayesa kuyang'ana mafuta anga a cholesterol ndipo ndikamamwa mapiritsi awa zonse ndizabwino, Posachedwa ndalandila mapiritsiwa kukhala ndi mabizinesi ochulukirapo, koma zidapezeka kuti ndikukulira, ndiye ndidabwerera ku atorvostatin ndipo ndikumva bwino

Mapiritsi abwino kwambiri omwe amachepetsa cholesterol yamagazi

Atorvastatin anathandiza kwambiri, cholesterol kuchokera pa 6, 4 inatsika mpaka 3, 8, ndimamwa koposa chaka, ndikuchepetsa pang'onopang'ono mlingo kuchokera 40 mg mpaka 10. Mwezi uliwonse, ndimapereka magazi kuti akandiyese. Tsopano ndikotheka kumwa mlingo wokonza, osati tsiku ndi tsiku, monga kale, koma mwachitsanzo 2 pa sabata. Momwe ndimamwa ndikadumwa sitiroko ndili ndi mankhwalawa kwa moyo wonse!

Mayi anga amamwa, adachotsedwa moyo. Anali ndi cholesterol 9, ndipo ndizambiri. Nditayamba kugwiritsa ntchito Atorvastatin, ndiye mwezi umodzi pambuyo pake zidapezeka: cholesterol idayamba kukhala yabwinobwino. Koma iye, kamodzi chinthu choterechi, amakhala ataledzera nthawi zonse, chifukwa thupi palokha silimayendetsa mulingo wake chifukwa cha kuperewera kwa metabolic. Palibe mavuto omwe adawonedwa.

Atorvastatin anabwezeretsa cholesterol yanga mwachizolowezi. Ngakhale zidakwezedwa kale komanso zakudya zopanda mchere komanso zopanda mafuta sizinathandize, koma mankhwalawa adathandiza. Ndimatsata minofu, popeza ma statins amatha kuwawononga ndikuyambitsa kufooka. Ndikukulangizani kuti muchite izi kwa onse omwe amamwa mankhwala a gululi.

• Zosagwirizana ndi mankhwala ambiri.

Mankhwalawa adawerengedwa kwa agogo anga, popeza iye, kuwonjezera pa matenda oopsa, ali ndi cholesterol yayikulu. Koma, mwamwayi, mankhwalawa amayenda bwino ndi mankhwala ambiri a antihypertensive.

Pa gawo loyambirira, mankhwalawa amayenera kumwedwa kamodzi patsiku, koma ndikofunikira kwambiri kuwunika kuchuluka kwa cholesterol m'magazi, ndiko kuti, kukayezetsa. Pambuyo poyesedwa kuti athandizidwe kuti mankhwalawo amagwira ntchito popanda kuwonetsa kwa pathological, mlingo ungathe kuchuluka. Ndikofunikira kuyang'anitsitsa mosamala kuti munthawi yamankhwala musagwiritse ntchito mankhwala ena omwe angakulitse chinthu yogwira ntchito m'magazi am'magazi, zomwe zingayambitse zotsatira zosasangalatsa. Mankhwalawa amaphatikizapo maantibayotiki, mankhwala antifungal, nicotinic acid.

Pakutha kwa mwezi woyamba kumwa kolesterol yanga, agogo anga anali atatsika ndipo anali osadalirika.

Tsoka ilo, vuto la cholesterol yayikulu lero limakhudza ambiri. Ngati mudakali aang'ono thupi limatha kuthana ndi cholesterol yowopsa, ndiye kuti patatha zaka 35 ndikofunikira kuyang'anitsitsa thanzi ndi kuchuluka konse kwa magazi. Ndikwabwino kudziwa kolesterol yomweyo osalola kuwonjezeka pamwamba pazovomerezeka. Ngati mutha kuyesa chaka chilichonse, ndipo nthawi zambiri, ndiye kuti mutha kudziwa kayendedwe ka cholesterol m'magazi.

Koma zitachitika kuti cholesterol imapitilira zomwe sizinachitike, ndiye kuti simuyenera kuyika mankhwala mu bokosi lalitali, muyenera kumwa mankhwala oyenera. Atorvastatin ndi mankhwala odziwika bwino ochepetsa cholesterol.

Mankhwalawa ndiokwera mtengo, amagula ma ruble pafupifupi 160-180, amagulitsidwa pa mankhwala aliwonse, mtengo wake umadalira malire amtundu wa mankhwala ena.

Atorvastatin imakhala yothandiza pokhapokha pazakudya zoyenera, zalembedwa m'malangizo, adotolo adabwereza izi atalembera mapiritsi a Atorvastatin.

Ndikofunikira kwambiri kuyesedwa musanayambe chithandizo kuti mutsimikizire kuchuluka kwa cholesterol yomwe yakwera, izi ndizofunikira kuti muwerenge molondola kuchuluka kwa mankhwalawa. M'malo mwanga, anali piritsi limodzi katatu pa tsiku kwa mwezi umodzi. Mlingo umatha kukhala wosiyana, mpaka mapiritsi 8, koma zonsezi zimayikidwa ndikuyang'aniridwa ndi katswiri.

Patatha mwezi umodzi, kuyezetsa magazi adakonzekera kuti adziwe ngati mankhwalawo alimbana kapena ayi. Pambuyo pa nthawi iyi, ndinaperekanso magazi, monga momwe zotsatira zake zinawonekera, zotsatira zake zinali ndipo panali kuchepa kwakukulu kwa cholesterol, koma komabe mulingo wake udali kunja kwa chizolowezi, adasankha kumwa Atorvastatin kwa masabata ena a 2 omwe ali ndi mlingo womwewo ndikumwa nthawi yomweyo mkaka waminyewa ya chiwindi. Zakudya izi zimathandizanso kutsitsa cholesterol.

Pambuyo pa masabata ena awiri, mayesowo adabwezeretsa, ndinapumira modekha, koma ichi sichifukwa kupumula. Inde, mankhwala Atorvastatin adathetsedwa, koma kudya kokha ndikuwunikira nthawi zonse zaumoyo.

Mankhwalawa adandithandizira, ndidabweretsa cholesterol yokhazikika, ndimangofunika kudya zakudya zowonjezera, apo ayi padzakhala zovuta zina: cholesterol - Atorvastatin ndi mosemphanitsa, ndipo pali zovuta ndi chiwindi (kuwerenga zotsatira zoyipa). Mankhwalawa ndiokwera mtengo, zochita zake sizoyipa kuposa zomwe zimatengedwera kunja, koma anyamata, muyenera kuchoka pamapangidwe am'mimba ndikumangirira ndi batala, soseji ndi maswiti ndi zina zosangalatsa. Eya ..

Zakudya zomwe zili ndi cholesterol yambiri ndizofunikira kwambiri. Agogo anga aakazi anali ndi cholesterol yokwanira 10 mmol / L. Dotolo adalangiza kuti azitsatira kadyedwe kena: mafuta ochepa a nyama (ngati nyama, ndiye nkhuku yonenepa kwambiri, nkhuku), masamba ambiri, zipatso (makamaka zipatso zosapezekanso), samalani mankhwalawa akumwa madzi. Atorvastatin adapangidwa kuchokera ku mankhwala. Agogo aakazi ankamwa mankhwalawa kamodzi patsiku. Pambuyo pa miyezi isanu ndi umodzi, zotsatirazi zidakwaniritsidwa: kulemera kunachepetsedwa ndi 14 makilogalamu (zakudya zoyenera zidachita mbali), cholesterol idakhala yabwinobwino. Tsopano chiwopsezo cha atherosulinosis chatha.

Mitengo ya Atorvastatin m'masitolo ogulitsa mankhwala ku Moscow

Madokotala amawunika za atorvastatin

Mankhwala ali kutchulidwa achire zotsatira mankhwalawa hyperlipidemic zinthu limodzi ndi matenda a mtima. Kuphatikiza kwamtengo kwamtengo wapatali ndikuyenda bwino kwa mankhwalawa.

Pali kuthekera kwa mavuto.

Kugwiritsa ntchito kumatheka pokhapokha kukambirana ndi kuvomereza kwa akatswiri.

Mankhwala abwino kwambiri komanso othandizira kukhala ndi zotsika mtengo pochizira matenda oopsa.

Zomwe zachitika kuchipatala kwakanthawi kochepa pogwiritsira ntchito zikuwonetsa kuti mankhwala othandizira sayenera kukhala okwera mtengo nthawi zonse, pali milandu yokana mankhwalawa chifukwa cha mtengo wotsika, munthu amaganiza kuti ndi wotsika mtengo, chifukwa chake sichithandiza.

Mtengo wa mankhwalawa, kupezeka kwake kwa anthu mdziko lathu, ogwira ntchito mothandizidwa ndi zotsatira zake zazikulu zachilengedwe.

Zotsatira zoyipa zambiri za mankhwalawa, zomwe zimapezeka mu mankhwala ambiri kuchokera ku gulu la mankhwala ochepetsa lipid komanso ma statin, kufunika kowongolera mwamphamvu magazi.

Pafupifupi chilichonse chomwe anthu amadziwa chazinthu "atorvastatin" chimatengera mankhwala "Liprimar" woyambirira wa Pfizer. Makampani ambiri opanga mankhwala amapanga awo atorvastatin, koma. Sikuti nthawi zonse zinthu zimamuyendera bwino. Chifukwa chake, ngati simukusangalala ndi zotsatira za kumwa atorvastatin, kusakhutira kumeneku kuyenera kukhala komwe kumadziwika chifukwa cha mankhwalawa, makamaka ngati mtengo wake ndi ma ruble 100-200. Pali ma envelopu a lypimar omwe awonetsa kufanana kwazachipatala - osachepera malingana ndi kuthekera kwawo kutsitsa cholesterol yamagazi. Chitsanzo ndi atoris. Pamtengo wotsika wa generic lypimar, katundu wina wosasangalatsa nthawi zina amapezeka - pafupipafupi zotsatira zoyipa zimakhala zapamwamba kwambiri kuposa zomwe zidagwiritsidwa ntchito ndi mankhwala oyambirirawo. Ndiye kuti, ndalama ndi mtengo wotsika mtengo wa zinthu zomwe zinagulidwa mosadziwa ndipo zakonzedwa ngati miyala ya mtengo wina “atorvastatin” wotsika mtengo. Atorvastatin, limodzi ndi rosuvastatin, ndimapulogalamu awiri othandiza kwambiri omwe alembedwa ku Russia. Zowona, muyenera kumvetsetsa kusiyana pakati pa atorvastatin wapachiyambi - Liprimar, ndi ma generics. Si zinsinsi zonse zaukadaulo zomwe zitha kupangidwanso ndi kampani yopanga mankhwala yomwe sinapangitse mankhwalawa. Chifukwa chake, muyenera kusankha mankhwalawo (kuphatikiza ma statins) omwe ali ndi zotsatira zabwino za maphunziro pazofanana ndi achire. Mwachitsanzo, atoris ndiye generic wophunziridwa kwambiri wa atorvastatin. Ndikwabwino kudalira dokotala pankhaniyi, kumvetsetsa nthawi yomweyo kuti si madokotala onse omwe ali ofanana.

Ma Statin sangakhale otsika mtengo kwambiri, apo ayi ayenera kukhala okonzekera mwina chifukwa cha kusowa kwa zotsatira zake kapena kuwonetsa pafupipafupi zotsatira zoyipa. Pali mitundu yambiri yamagetsi a atorvastatin, koma si onse omwe ali oyenera kudalirika kofanana ndi choyambirira cha mankhwala "Liprimar".

Ndidalemba chizindikiro, chomwe chikuyenera kuperekedwa pano, chokhacho (!) Kwa mankhwala a Liprimar ndi zida zake zapamwamba kwambiri. "Atorvastatins" opanda chiyembekezo a rubles 100-200 sakhala pano.

Ndemanga za odwala a Atorvastatin

Posachedwa, ndidachita opareshoni ya carotid artery (china chake chinali cham'kamwa, chizungulire m'mutu mwanga - atherosulinosis yamatumbo yapezeka). Nthawi zonse muyenera kuthana ndi kuwonjezereka kwa cholesterol yamagazi. Malinga ndikutuluka kwa dotolo, ndimameza Atorvastatin (20 mg.) Tsopano nditatha kumwa, ululu m'matumbo mwanga udawoneka. Sindimamwa izi - palibe chomwe chimandipweteka! Kungakhale kofunikira kusinthira ku mankhwala ena.

Zabwino zonse! Ndipo "Atorvastatin" idandipatsa mavuto, sindimafuna kukhala ndi moyo. Kuyimitsidwa kutenga pamenepo. Ndipo tsopano ndagula "Krestor", mwina ndibwino. Palibe kopita. Ngakhale kuti makilogalamu 10 adatsitsidwa mchaka (ngakhale sizikupweteka kutaya makilogalamu 7-8 musanakhazikike bwinobwino), cholesterol siyidaponya dontho, m'malo mwake idakhala 9, m'malo 8 pachaka chapitacho. Zina zophatikizidwa muzogona zonse kuyambira 30 mpaka 45. Ndipo zolembazo zili mu coronary yamanja ndizoposa 70%. Adasankha opanga stent kuti ayikidwe pamenepo, koma sangathe kuzichita panobe, zitsulo zikungodikirira chilimwe. Pazaka zadzidzidzi zokha pamakhala ma stense ngati magazi atatuluka. Tsopano ndikukhala pa Keg ya ufa. Anthu, pitani ziwiya za ultrasound ndi madotolo osiyanasiyana! Ndazichita kale kuposa kale, koma adokotala omaliza ndi okhawo amene adawona chikwangwani chachikulu ichi! Koma osati m'miyezi isanu (kuyambira nthawi yomaliza ya ultrasound) pomwe idapangidwa, yoposa 70%.

Mankhwala abwinobwino, ndimalekerera kumwa, sindimawona mavuto aliwonse. Cholesterol lowers, vuto lokhalo linali ndi triglycerides atakhazikika pamalo amodzi. Koma ataganiza izi, adalumikiza Dibicor ndi Atorvastatin ndipo ndizo zonse, triglycerides nawonso ali pamwambamwamba monga mwazonse.

Mayi anga adachotsedwa "Atorvastatin sz" miyezi isanu ndi umodzi yapitayo. Amamwa mowerengera, inde, osakhala wopanda chakudya. Tsopano ndi wochepa thupi kwambiri, adaganiza zongotsatira zakudya zina. Nthawi zambiri mumayang'ana cholesterol, yomwe tsopano ndi yachilendo.

Ndakhala ndikutenga atorvastatin kwa zaka 10, nditangogwira mwadzidzidzi ndikum'peza, ndipo posakhalitsa opaleshoni yam'mimba idachitidwa. Ndikuganiza kuti mankhwalawa amandithandiza kwambiri ku cholesterol, ndipo kwa zaka zingapo tsopano, akandiunika, cholesterol ndiyachilendo.

Pamene cholesterol yoposa 9 yapezeka m'mayeso anga a magazi, ndinalingalira kuti mankhwalawo azikhala okwera mtengo komanso ogwira ntchito kwambiri. Koma kuchipatala, atalandira mapiritsi a ma ruble 100, adachita mantha! Koma moona ndinamwa paketi iyi, monga momwe amandipatsa tsiku lililonse kwausiku. Anadutsa reanalysis ndipo palibe zosintha zomwe zidachitika, chifukwa panali cholesterol ya awiri, ndikugwira bwino. Chifukwa chake ndichofunika kumwa mapiritsi ngati amenewo, osakhulupirika. Kupatula apo, uku ndi umagwirira ndipo sizikudziwika zomwe zingachitike ndi thupi pogwiritsa ntchito nthawi yayitali. Ndinakana mapiritsi awa, ndikupempha kuti mupereke mankhwala abwinoko, osati phokoso.

Anayamwa kuti atorvastine ndi cholesterol 6.5. Ndimamwa 10 mg patsiku - sindikuwona njira yapadera, koma pali zovuta zingapo zoyipa. Ndikuyesa kusinthana ndi chakudya.

Ndakhala ndikutenga Atorvastatin kwa zaka ziwiri pamlingo wa 20 mg. Mbiri ya lipid ndiyachilendo, koma china chake chiwindi chidayamba kugwira ntchito.

Sindinganene kuti mankhwalawa ndi odabwitsa. Adalembera bambo anga pamtengo wa 60 mg / tsiku, chifukwa cholesterol yayikulu ndi chibadwa chathu. Ubwino - kugwiritsa ntchito mosavuta (mosasamala kanthu za chakudya). Chuma - Sindinazindikire kusintha kwina kulikonse kwaumoyo kumapeto kwa chithandizo. Cholesterol monga momwe imaposa 7 mmol / l, ndipo idatsalira. Patatha miyezi isanu ndi umodzi, cholesterol ya abambo anga inatseketsa mitsempha ya popliteal, yomwe inakhumudwitsa necrosis ya chala chachikulucho. Tsopano, pofuna kupewa kudulidwa kawiri pachaka, abambo amapangidwa ndi mankhwala okwera mtengo kwambiri. Malingaliro anga, atorvastatin ndi mankhwala osagwira ntchito konse, ndipo sindikudziwa zomwe madokotala amatiuza.

Wothandizira adapereka mankhwalawa kwa mwamuna wake, ngakhale kuti cholesterol yake siinakwezedwa. Koma kupanikizika ndikokwera, choncho, limodzi ndi mankhwala omwe amachepetsa kupanikizika, dokotala adalimbikitsa kumwa atorvastatin 50 mg kamodzi patsiku. Komabe, adalongosola izi poti patatha zaka 40, ma statin amafunsidwa kuti azikhala ndi prophylactic. Mwamuna wake anali wabwinobwino pogwiritsa ntchito atorvastatin ndipo sizinadzetse mavuto. Mtengo uli mkati mwa ma ruble 150.

Atorvastatin (makamaka, monga ma statins ena) amagwiritsidwa ntchito osati kungokhala cholesterol yokwezeka, komanso akulimbikitsidwa kupewa matenda a mtima ndi atherosclerosis, chifukwa ndakhala ndikugula kwa zaka zingapo tsopano. Ndipo posachedwapa, pulofesa (wophunzirira zamankhwala) adatiuza kuti malinga ndi malingaliro atsopano, ma statin akuyenera kutengedwa pambuyo pa zaka 40 mu Mlingo wocheperako komanso mosasamala za cholesterol. Koma muyenera kumwa mosalekeza - pokhapokha ngati pali zomwe zingachitike.

Ndinayamba kumwa Atorvastatin nditatha kuyesera mankhwala onse azikhalidwe kuti ndichepetse cholesterol. Anali ndi chiyembekezo chachikulu chamadyedwe, koma sizinaphule - cholesterol idakhalabe pa 7.5. Mutatha maphunziro a Atorvastatin, chizindikirocho chinakhala 4.5. Ndidakondwera ndikuleka kumwa mankhwalawo. Koma zinali pomwepo! Cholesterol yabwerera m'migawo yake yakale. Adzakhala paubwenzi ndi Atorvastatin kwa nthawi yayitali.

Ndinagula wachibale wanga amene anali ndi matenda ashuga ndipo anali ndi vuto lotenga matenda a mtima. Zakudya zamafuta zotsitsa mafuta m'thupi ndi piritsi limodzi la atorvastatin patsiku. Dokotala wandiuza kuti ndibwere pakatha milungu 4 - kusintha kwa mankhwalawa kungakhale kofunikira. Pakupita mwezi umodzi, cholesterol inali yofanana, kotero iwo sanakulitse mlingo. Mpaka pano, wachibale wakhala akutenga atorvastatin zoposa chaka (+ chakudya ndi masewera) - cholesterol ndiyachilendo.

Mayi anga amamwa, adachotsedwa moyo. Anali ndi cholesterol 9, yomwe ndi yambiri. Nditayamba kugwiritsa ntchito Atorvastatin, ndiye mwezi umodzi pambuyo pake zidapezeka: cholesterol idayamba kukhala yabwinobwino. Koma iye, kamodzi chinthu choterechi, amakhala ataledzera nthawi zonse, chifukwa thupi palokha silimayendetsa mulingo wake chifukwa cholephera metabolic. Palibe mavuto omwe adawonedwa.

Kufotokozera kwapfupi

Atorvastatin ndi mankhwala a hypolipidemic omwe ali m'gulu la ma statins. Matenda a mtima omwe amakhala m'magazi amodzi mwazomwe zimayambitsa matenda a mtima. Muzu wa izi wagona atherosulinosis ya m'mitsempha yamagazi. Chiwopsezo cha zotupa za atherosselotic zamitsempha yamagazi zimawonjezeka kwambiri pamaso pa zinthu zosasinthika (cholowa, champhongo, mtundu, ukalamba) komanso zosinthika (kunenepa kwambiri, kusuta, shuga, dyslipidemia). Kuphwanya kwa metabolism ya carbohydrate, yomwe imagwira ntchito yofunika kwambiri pathogenesis ya atherosulinosis, imawonetsedwa ndikuwonjezereka kwa kuchuluka kwa cholesterol "yoyipa" (otsika kachulukidwe ka lipoproteins kapena LDL) ndi triglycerides yotsika nthawi yomweyo pamlingo wa cholesterol "wabwino" (high density lipoproteins kapena HDL). Mu maphunziro akulu ambiri, zidawonetsedwa bwino kuti cholesterol, LDL ndi HDL zimagwirizana kwambiri ndi kuchuluka kwaimfa kuchokera ku ischemia. Poyerekeza ndi maziko a hypercholesterolemia, chiwopsezo cha zochitika zamtima (kuphatikizapo imfa) zimachulukana kangapo.Nthawi yomweyo, zinatsimikiziridwa mwanjira yoti kuti kuchepa kwakukulu (mpaka 35%) mu ndende ya LDL, chiwopsezo cha kufa chimachepa limodzi. Asayansi atsimikiziranso kuti kutsitsa cholesterol yokwanira ndi 10% kumachepetsa chiopsezo cha kufa kwa matenda a coronary ndi 40%. Zonsezi ndi umboni woonekeratu wofunika kwambiri wa lipid-kuchepetsa mankhwala popewa matenda amtima. Mpaka pano, ma statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) ndiwo mankhwala oyambira pokonza dyslipidemic ndi chithandizo cha atherosulinosis. Amachepetsa mulingo wa LDL ndi atherogenic triglycerides ndikuwonjezera plasma ya HDL. Ma Statin ali ndi umboni wokwanira wozikidwa pazotsatira za mayeso ambiri azachipatala. Mankhwala a gululi amachepetsa chiwopsezo cha matenda atherosselotic ndi zovuta zomwe zimayenderana ndi iwo, zimalepheretsa kuchuluka kwa mapangidwe a atherosulinotic plaque komanso zimakhudza matenda omwe si a mtima.

Atorvastatin pakadali pano ndi imodzi mwazidziwitso zotchuka komanso zophunziridwa kwambiri mu gulu la statin. Ichi ndi mankhwala opangidwa mokwanira omwe alowa mokhazikika muzochita zamankhwala kuyambira kumapeto kwa zaka 90 zapitazi. Kugwiritsa ntchito kwa atorvastatin pakuchotsa kwa zovuta zamtima, zomwe zikuwonetsedwa zingapo zoyeserera zamankhwala, zimatilola kuvomereza kugwiritsidwa ntchito kwake osati kwa odwala omwe ali ndi matenda a mtima, komanso kwa anthu omwe ali pachiwopsezo cha zochitika zamtima motsutsana ndi maziko a dyslipidemia. Kafukufuku wodziwika kwambiri wazokhudza zochita za hypolipidemic wa atorvastatin - CURVES - adachitika mkati mwa zaka zam'ma 1990 ku United States. Phunziroli, pamene atorvastatin imagwiritsidwa ntchito pa 10 mg wa 40 patsiku, kuchepa kwa cholesterol yoyipa "kunachitika ndi 38-51%."

Hypocholesterolemic mphamvu ya mankhwalawa imayamba msanga ndikuwonekera mkati mwa masiku 14 kuyambira chiyambi cha makonzedwe. Ngakhale mlingo woyambirira wa atorvastatin, 10 mg, umatha kupititsa patsogolo kukonzanso kwamatenda a mtima chifukwa chakuchepa kwa LDL ndi 30% kapena kupitirira. Atorvastatin imatha kutengedwa pakadontho kakang'ono kuposa ma statin ena (simvastatin, lovastatin, pravastatin ndi fluvastatin) ndi njira yofananira yothandizirana. Ndi maphunziro a pafupipafupi a mankhwala ambiri odwala omwe ali ndi vuto la mtima munthawi yochepa yotere. (Pafupifupi miyezi itatu), cholinga cha LDL chimakwaniritsidwa. Atorvastatin bwino amachepetsa mulingo wa atherogenic triglycerides poyerekeza ndi mankhwala ena mgululi. Chithandizo cha atorvastatin chikuchitika motsutsana ndi maziko azakudya zapadera, zomwe zimapereka kuchepa kwa mafuta a nyama mthupi ndipo zimapangitsidwa ndi mavitamini ndi mchere. Mlingo umatsimikiziridwa payekhapayekha ndipo zimatengera muyeso woyamba wa cholesterol. Mlingo woyamba wa mankhwalawa ndi 10 mg, pazipita ndi 80 mg.

Pharmacology

Hypolipidemic mankhwala ochokera pagulu la statins. Kusankha mpikisano wosankha wa HMG-CoA reductase, enzyme yomwe imatembenuza 3-hydroxy-3-methylglutarylcoenzyme A ku mevalonic acid, yomwe ndiyo kutsogolo kwa sterols, kuphatikiza cholesterol. Triglycerides ndi cholesterol m'chiwindi chimaphatikizidwa ndi VLDL, imalowa m'magazi am'magazi ndipo imatengedwa kupita ndi zotumphukira. LDL imapangidwa kuchokera ku VLDL panthawi yolumikizirana ndi LDL receptors. Atorvastatin amachepetsa plasma woipa wa cholesterol ndi lipoproteins poletsa HMG-CoA reductase, kapangidwe ka cholesterol m'chiwindi, komanso kuchuluka kwa LDL receptors m'chiwindi pamaselo a cell, zomwe zimapangitsa kukulira komanso kupsya kwa LDL.

Imachepetsa kupangika kwa LDL, imayambitsa kuwonjezereka komanso kulimbikira mu ntchito ya ma LDL receptors. Amachepetsa LDL odwala omwe ali ndi homozygous Famer hypercholesterolemia, omwe nthawi zambiri samayankha pochiza ndi lipid-kuchepetsa mankhwala.

Kuchepetsa kuchuluka kwa cholesterol yokwanira ndi 30-46%, LDL - mwa 41-61%, apolipoprotein B - ndi 34-50% ndi triglycerides - pofika 14-33%, kumapangitsa kuchuluka kwa HDL cholesterol ndi apolipoprotein A. Mlingo modzipereka umachepetsa zinthu za LDL mu odwala homozygous cholowa hypercholesterolemia kugonjetsedwa ndi mankhwala ena hypolipidemic wothandizira.

Pharmacokinetics

Mafuta ndi okwera. Ndi_max mu plasma imafikiridwa pambuyo pa maola 1-2. Zakudya zimachepetsa kuthamanga ndi kutalika kwa mankhwalawa (ndi 25% ndi 9%, motsatana), koma kuchepa kwa cholesterol ya LDL kuli chimodzimodzi ndi kusala kwa atorvastatin. Kuchulukitsidwa kwa atorvastatin pamene ntchito madzulo kumatsika kuposa m'mawa (pafupifupi 30%). Ubale wapakati pakati pa kuchuluka kwa mayamwidwe ndi mlingo wa mankhwalawo unawululidwa.

Bioavailability - 12%, zokhudza bioavailability wa zoletsa ntchito motsutsana HMG-CoA reductase - 30%. Systemic bioavailability yochepa imayamba chifukwa cha kagayidwe kachakudya m'matumbo am'mimba komanso mu "gawo loyamba" kudzera pachiwindi.

Pakati V_d - 381 l. Kumangiriza kwa mapuloteni a plasma - 98%.

Amapangidwa makamaka mu chiwindi mothandizidwa ndi cytochrome CYP3A4, CYP3A5 ndi CYP3A7 popanga ma metabolac yogwira metabolac (ortho- ndi para-hydroxylated, mankhwala a beta-oxidation). In vitro, ortho- ndi para-hydroxylated metabolites imalepheretsa kusintha kwa HMG-CoA, kufananizidwa ndi atorvastatin. Mphamvu yoletsa kukonzekera kwa mankhwala oletsa HMG-CoA reductase ndi pafupifupi 70% yotsimikizika ndi ntchito yozungulira metabolites.

Imafukusidwa mu ndulu pambuyo pakuchepa kwa hepatic ndi / kapena metabolism yowonjezera (sikuti imayambiranso kwambiri). T_1/2 - Maola 14. Ntchito za Inhibitory motsutsana ndi HMG-CoA reductase zimangokhalira pafupifupi 20-30 maola chifukwa cha kukhalapo kwa metabolites yogwira. Osachepera 2% ya mlingo wa pakamwa amadziwika mu mkodzo. Sichotsetsedweratu pa hemodialysis.

Pharmacokinetics pamagulu apadera a odwala

Ndi_max mwa akazi ndiwokwera ndi 20%, AUC - wotsika ndi 10%.

Ndi_max Odwala omwe ali ndi vuto la chidakwa cha chiwindi ndiwokhuta kuposa 16, AUC - 11 kuchulukanso kuposa masiku onse.

Kutulutsa Fomu

Mapiritsiwo anali atakulungidwa ndi filimu yotulutsa yoyera kapena yoyera, yozungulira, ya biconvex, pamtanda - pafupifupi yoyera.

Omwe amathandizira: calcium hydrogen phosphate dihydrate - 27 mg, sodium carboxymethyl - 3 mg, wowuma wa mbatata - 3.5 mg, magnesium stearate - 0,65 mg, cellcrystalline selulosi - 45 mg.

Kuphatikizika kwa zokutira kwa filimuyi: kuyanika ndi 3 mg (osakaniza opadra oyera kapena osakaniza opangidwa ndi vivacoate angagwiritsidwe ntchito), kuphatikiza hypromellose (hydroxypropylmethyl cellulose) - 1.0125 mg, hyprolysis (hydroxypropyl cellulose) - 1.0125 mg, talc - 0.6 mg, titanium dioxide - 0,375 mg.

Ma PC 10 - matumba otumphuka (1) - mapaketi a makatoni.
Ma PC 10 - mapepala otumphukira (2) - mapaketi a makatoni.
Ma PC 10 - matumba otumphukira (3) - mapaketi a makatoni.
15 ma PC. - matumba otumphuka (1) - mapaketi a makatoni.
15 ma PC. - mapepala otumphukira (2) - mapaketi a makatoni.
15 ma PC. - matumba otumphukira (3) - mapaketi a makatoni.
30 ma PC - matumba otumphuka (1) - mapaketi a makatoni.
30 ma PC - mapepala otumphukira (2) - mapaketi a makatoni.
30 ma PC - matumba otumphukira (3) - mapaketi a makatoni.

Asanapange mankhwala Atorvastatin, wodwalayo ayenera kulimbikitsa zakudya zochepetsa lipid, zomwe ayenera kupitiriza kuzitsatira panthawi yonse ya mankhwala.

Mankhwala amatengedwa pakamwa, nthawi iliyonse masana ndi chakudya kapena osasamala nthawi yakudya.

Mlingo umasankhidwa poganizira milingo yoyambirira ya cholesterol / LDL, cholinga cha mankhwala ndi zotsatira zake. Mlingo woyambirira ndi pafupifupi 10 mg 1 nthawi / tsiku. Mlingo umasiyana 10 mpaka 80 mg 1 nthawi / tsiku.

Kumayambiriro kwa mankhwalawa komanso / kapena pakuwonjezeka kwa mlingo wa Atorvastatin, ndikofunikira kuyang'anitsitsa zam'mapapo a plasma masabata onse a 2-4 ndikusintha mlingo moyenerera.

Ndi hypercholesterolemia yoyamba ndi hyperlipidemia yosakanikirana, komanso mtundu wa III ndi IV hyperlipidemia malinga ndi Fredrickson, nthawi zambiri ndizokwanira kupereka mankhwala pa 10 mg 1 nthawi / tsiku. Chithandizo chachikulu chamankhwala chimawonedwa pambuyo pa masabata awiri, mphamvu yayikulu yochizira imawonedwa pambuyo pa masabata anayi. Ndi chithandizo cha nthawi yayitali, izi zimapitirira.

Ndi homozygous achibale hypercholesterolemia, mankhwala mankhwala mankhwala 80 mg (4 mapiritsi a 20 mg) 1 nthawi / tsiku.

Kugwiritsa ntchito kwa odwala omwe ali ndi vuto la impso ndi matenda a impso sikukhudza kuchuluka kwa atorvastatin m'madzi am'magazi kapena kuchepa kwa cholesterol / LDL akagwiritsidwa ntchito, chifukwa chake, kusintha kwa mankhwalawa sikofunikira.

Ndi kulephera kwa chiwindi, mlingo uyenera kuchepetsedwa.

Mukamagwiritsa ntchito mankhwalawa odwala okalamba, panalibe kusiyana pakukhwimitsa chitetezo, kugwira ntchito mwamphamvu, kapena kukwaniritsa zolinga za kuchepetsa lipid poyerekeza ndi anthu ambiri.

Kuchita

Chiwopsezo cha myopathy munthawi ya mankhwala ndi mankhwala ena a mkalasiyi chimawonjezeka ndikugwiritsa ntchito munthawi yomweyo cyclosporine, fibrate, erythromycin, antifungals zokhudzana ndi azoles, ndi nicotinic acid.

Ndi munthawi yomweyo kugwiritsa ntchito mankhwala Atorvastatin ndi kuyimitsidwa komwe kuli ndi magnesium ndi aluminium hydroxide, kuchuluka kwa atorvastatin m'madzi a m'magazi kunatsika pafupifupi 35%, koma kuchepa kwa kuchuluka kwa cholesterol / LDL sikunasinthe.

Kugwiritsa ntchito pamodzi kwa atorvastatin sikukhudza pharmacokinetics ya antipyrine (phenazone), motero, kuyanjana ndi mankhwala ena omwe amapangidwa ndi cytochrome isoenzymes yomweyo sayembekezereka.

Ndi munthawi yomweyo kugwiritsa ntchito colestipol, kuchuluka kwa atorvastatin m'madzi a m'magazi kunachepa pafupifupi 25%. Komabe, lipid-kutsitsa mphamvu ya kuphatikiza kwa atorvastatin ndi colestipol imaposa ya aliyense mankhwala payekhapayekha.

Pogwiritsa ntchito mobwerezabwereza digoxin ndi atorvastatin pa 10 mg C_ss plasma digoxin sanasinthe. Komabe, pamene digoxin imagwiritsidwa ntchito limodzi ndi atorvastatin pa mlingo wa 80 mg / tsiku, kuchuluka kwa digoxin kumawonjezeka pafupifupi 20%. Odwala omwe amalandira digoxin kuphatikizapo mankhwala a Atorvastatin ayenera kuonedwa.

Ndi munthawi yomweyo kugwiritsa ntchito atorvastatin ndi erythromycin (500 mg 4 nthawi / tsiku) kapena clarithromycin (500 mg 2 nthawi / tsiku), zomwe zimalepheretsa cytochrome CYP3A4, kuwonjezeka kwa kuchuluka kwa atorvastatin m'magazi a magazi.

Ndi munthawi yomweyo kugwiritsa ntchito atorvastatin (10 mg 1 nthawi / tsiku) ndi azithromycin (500 mg 1 nthawi / tsiku), kuchuluka kwa atorvastatin m'madzi a m'magazi sikunasinthe.

Atorvastatin inalibe gawo lalikulu pakukhudzidwa kwa terfenadine mu plasma yamagazi, yomwe imapangidwa makamaka ndi cytochrome CYP3A4, pankhaniyi, ndizokayikitsa kuti atorvastatin ingakhudze kwambiri magawo a pharmacokinetic a magawo ena a CYP3A4.

Pogwiritsa ntchito munthawi yomweyo atorvastatin komanso kulera kwa makonzedwe amkamwa okhala ndi norethindrone ndi ethinyl estradiol, kuwonjezeka kwakukulu mu AUC ya norethindrone ndi ethinyl estradiol kumawonedwa ndi pafupifupi 30% ndi 20%, motero. Izi zimayenera kuganiziridwa posankha njira yakulera yapakati ya mkazi yemwe amalandila Atorvastatin.

Kugwiritsa ntchito munthawi yomweyo mankhwala osokoneza bongo omwe amachepetsa kuchuluka kwa mahomoni amkati (kuphatikizapo cimetidine, ketoconazole, spironolactone) kumawonjezera chiopsezo chochepetsera mahomoni amkati a steroid (kusamala kuyenera kuchitidwa).

Mukamaphunzira kuyanjana kwa atorvastatin ndi warfarin ndi cimetidine, palibe kuyanjana kwakukulu kwachipatala komwe kunapezeka.

Ndi munthawi yomweyo kugwiritsa ntchito atorvastatin 80 mg ndi amlodipine 10 mg, pharmacokinetics ya atorvastatin m'chigawo chofanana sichinasinthe.

Palibe zovuta zovuta zamatenda za atorvastatin ndi antihypertgency zomwe zikuwoneka.

Kugwiritsa ntchito kwa atorvastatin ndi ma proteinase inhibitors odziwika ngati CYP3A4 inhibitors limodzi ndi kuwonjezeka kwa plasma mozama kwa atorvastatin.

Kusagwirizana kwa mankhwala sikudziwika.

Zotsatira zoyipa

Kuchokera kwamanjenje: oposa 2% - kusowa tulo, chizungulire, osakwana 2% - mutu, asthenia, malaise, kugona, malodza, paresthesias, zotupa zam'mitsempha, amnesia, kutopa kwa m'maganizo, ataxia, kupweteka kwamitsempha yam'maso, hyperkinesis, migraine Hypesthesia, kulephera kudziwa.

Kuchokera pazinthu zam'maganizo: zosakwana 2% - amblyopia, tinnitus, conjunctiva, malo osokonezeka, zotupa m'mimba ya retina, ugonthi, glaucoma, parosmia, kuchepera kwa kukoma, kupotoza kwa kukoma.

Kuchokera pamtima dongosolo: oposa 2% - kupweteka pachifuwa, zosakwana 2% - palpitations, vasodilation zviratidzo, orthostatic hypotension, kuchuluka kwa magazi, phlebitis, arrhythmia, angina pectoris.

Kuchokera ku hemopoietic dongosolo: zosakwana 2% - kuchepa magazi, lymphadenopathy, thrombocytopenia.

Kuchokera pakapumidwe: Nthawi zambiri 2% - bronchitis, rhinitis, kawirikawiri 2% - chibayo, dyspnea, kuchulukitsa kwa mphumu ya bronchial, nosebleeds.

Kuchokera mmimba: kawirikawiri 2% - nseru, osachepera 2% - kutentha pa chifuwa, kudzimbidwa kapena kutsegula m'mimba, kupweteka kwam'mimba, kupweteka kwam'mimba, kuchepa kapena kuchuluka kwa chilimbikitso, pakamwa pouma, kupindika, dysphagia, kusanza, stomatitis, esophagitis, glossitis, zilonda zam'mimba komanso zilonda zam'mimba zotupa, matenda am'mimba, chiwindi, biliary colic, cheilitis, duodenal ulcer, kapamba, cholestatic jaundice, kusokonezeka kwa chiwindi, kutsekemera magazi, melena, kutulutsa magazi pakhungu, tenesi.

Kuchokera ku minculoskeletal system: oposa 2% - nyamakazi, kawirikawiri 2% - mwendo kukokana, bursitis, tendosynovitis, myositis, myopathy, arthralgia, myalgia, rhabdomyolysis, torticollis, minofu hypertonicity, kuphatikiza kwapakati.

Kuchokera kwamikodzo dongosolo: pafupipafupi 2% - zotumphukira edema, zosakwana 2% - dysuria (kuphatikizapo polakiuria, nocturia, kwamikodzo mosapitirira kapena kwamikodzo kwamkodzo, kukodza kofunikira, nephritis, hematuria, nephrourolithiasis.

Kuchokera kumaliseche ndi ma gland a gland: ma zaidi a 2% - matenda a urogenital, ochepera 2% - kutaya magazi mu ukazi, metrorrhagia, epididymitis, kuchepa kwa libido, kusabala, kusokonezeka kwam'mimba, gynecomastia, mastodynia.

Pa khungu ndi subcutaneous zimakhala: oposa 2% - alopecia, xeroderma, kuchuluka thukuta, eczema, seborrhea, ecchymosis, petechiae.

Thupi lawo siligwirizana: zosakwana 2% - khungu loyenda, zotupa, kulumikizana dermatitis "kawirikawiri - urticaria, angioedema, nkhope edema, photosensitivity, anaphylaxis, erythema multiforme exudative (kuphatikiza Stevens-Johnson syndrome), poyizoni epermermal necrolysis (syndrome Lyella).

Kumbali ya zowonetsa zasayansi: ochepera 2% - hyperglycemia, hypoglycemia, kuchuluka kwa seramu CPK, albuminuria.

Zina: zosakwana 2% - kuchuluka kwa thupi, kuchuluka kwa gout.

• kuphatikiza ndi zakudya kuti muchepetse cholesterol yokwanira, cholesterol / LDL cholesterol, apolipoprotein B ndi triglycerides ndikuwonjezera cholesterol ya HDL kwa odwala omwe ali ndi hypercholesterolemia, heterozygous mabanja ndi osakhala achibale hypercholesterolemia komanso ophatikizika (osakanikirana) mtundu II hyperlipidemia b)
• kuphatikiza ndi zakudya zochizira odwala omwe ali ndi serum triglycerides (Fredrickson mtundu IV) ndi odwala omwe ali ndi dysbetalipoproteinemia (Fredrickson mtundu III), yemwe mankhwalawa amadya.
• Kuchepetsa kuchuluka kwa cholesterol ndi cholesterol / LDL odwala omwe ali ndi homozygous Famer hypercholesterolemia, pamene mankhwala othandizira pakudya ndi zina zomwe sizotsatira zamankhwala samagwira ntchito mokwanira.

Contraindication

• odwala matenda a chiwindi kapena kuwonjezeka kwa ntchito ya michere ya chiwindi yachilendo osadziwika (nthawi zopitilira 3 poyerekeza ndi VGN),
• kulephera kwa chiwindi (kuuma molingana ndi gulu la ana-Pugh A ndi B),
• mimba
• kuyamwa
• zaka mpaka 18 - (kuchita bwino ndi chitetezo sizinakhazikitsidwe),
• Hypersensitivity pamagawo a mankhwala.

Mochenjera, mankhwalawa ayenera kuthandizidwa kumwa mowa, mbiri yodwala matenda a chiwindi, kusakhazikika kwa elekitirodi, endocrine ndi matenda a metabolic, matenda oopsa a pachimake, sepsis yodwala, khunyu losalamulirika, kulowererapo kwakukulu kwamatenda am'mimba.

Mimba komanso kuyamwa

Atorvastatin imaphatikizidwa mu mimba ndi mkaka wa m'mawere (yoyamwitsa).

Sizikudziwika ngati atorvastatin amachotsedwa mkaka wa m'mawere. Popeza kuthekera kwa zovuta mu makanda, ngati kuli kotheka, kugwiritsa ntchito mankhwalawa panthawi yoyamwa kuyenera kuganizira kuthetsa kuyamwitsa.

Amayi a msinkhu wobereka ayenera kugwiritsa ntchito njira zokwanira zolerera panthawi ya chithandizo. Atorvastatin itha kutumizidwa kwa azimayi azaka zakubadwa pokhapokha ngati mwayi wokhala wochotsa umakhala wotsika kwambiri, ndipo wodwalayo amadziwitsidwa za ngozi yomwe ingachitike kwa mwana wosabadwayo panthawi ya chithandizo.

Gwiritsani ntchito ntchito yolakwika ya chiwindi

Chenjezo liyenera kuperekedwa kwa odwala omwe ali ndi mbiri ya matenda a chiwindi.

Kugwiritsira ntchito mankhwalawa kumaphatikizidwa kwa odwala omwe ali ndi matenda a chiwindi kapena kuwonjezeka kwa zochitika za chiwindi michere yachilendo osadziwika (nthawi zopitilira 3 poyerekeza ndi VGN) komanso kulephera kwa chiwindi (kuopsa molingana ndi gulu la ana-Pugh A ndi B).

Malangizo apadera

Asanayambe mankhwala ndi Atorvastatin, wodwalayo ayenera kuthandizidwa kudziwa kuchuluka kwa hypocholesterol, yomwe ayenera kutsatira panthawi yonse ya chithandizo. Kugwiritsa ntchito zoletsa za HMG-CoA reductase kuti muchepetse kuchuluka kwa lipids m'magazi kungayambitse kusintha kwa magawo a biochemical omwe amawonetsa ntchito ya chiwindi. Ntchito ya chiwindi iyenera kuyang'aniridwa isanayambike mankhwala, masabata 6, masabata 12 atayamba kugwiritsa ntchito mankhwalawa Atorvastatin komanso pambuyo poti mlingo uliwonse ukuwonjezeka, komanso, nthawi ndi nthawi, mwachitsanzo, miyezi isanu ndi umodzi iliyonse. Kuwonjezeka kwa ntchito ya hepatic michere mu seramu yamagazi imatha kuwonedwa pa mankhwala ndi Atorvastatin. Odwala omwe ali ndi chiwonjezeko cha ntchito ya enzyme ayenera kuyang'aniridwa mpaka zizindikirozo zibwerere pazabwino. Poona kuti ma ALT kapena MITUNDU yamakhalidwe apamwamba kwambiri kuposa katatu pa VGN, ndikulimbikitsidwa kuti muchepetse mlingo wa Atorvastatin kapena musiyeni chithandizo.

Atorvastatin iyenera kugwiritsidwa ntchito mosamala mu odwala omwe amamwa mowa kwambiri komanso / kapena omwe ali ndi matenda a chiwindi. Odwala chiwindi matenda kapena kuwonjezereka kwa ntchito ya aminotransferases yachidziwitso osadziwika amagwira ntchito monga contraindication poika Atorvastatin.

Chithandizo cha atorvastatin chingayambitse myopathy. Kuzindikira kwa myopathy (kupweteka kwa minofu ndi kufooka kophatikiza ndi kuwonjezeka kwa zochitika za CPK nthawi zopitilira 10 poyerekeza ndi VGN) kuyenera kufotokozedwa mwa odwala omwe ali ndi myalgia, kupweteka kwa minofu kapena kufooka komanso / kapena kuwonjezeka kwodziwika mu zochitika za CPK. Odwala ayenera kuchenjezedwa kuti ayenera kudziwitsa dokotala nthawi yomweyo za kuwoneka kosapweteka kapena kufooka m'misempha ngati akuphatikizidwa ndi malaise kapena malungo. Mankhwala a Atorvastatin ayenera kusiyidwa ngati pali kuwonjezeka kodziwika kwa zochitika za CPK kapena ngati pali myopathy yotsimikizika kapena yomwe ikukayikira. Chiwopsezo cha myopathy pochiza mankhwalawa amakalasi ena a mkalasi imeneyi chinawonjezeka ndi kugwiritsa ntchito nthawi yomweyo cyclosporine, fibrate, erythromycin, nicotinic acid kapena ma antifungal othandizira kuchokera ku gulu la azole. Ambiri mwa mankhwalawa amalepheretsa CYP3A4 -edi-metabolism metabolism ndi / kapena kayendedwe ka mankhwala. Atorvastatin ndi biotransformed mothandizidwa ndi CYP3A4. Popanga atorvastatin osakanikirana ndi ma fupa, erythromycin, immunosuppressive othandizira, azole antifungals, kapena nicotinic acid mu hypolipidemic Mlingo, phindu lomwe likuyembekezeka komanso chiopsezo chamankhwala liyenera kuyesedwa mosamala ndipo odwala ayenera kuyang'aniridwa pafupipafupi kuti adziwe kupweteka kwa minofu kapena kufooka, makamaka m'miyezi yoyambirira mankhwala ndi nthawi kuchuluka Mlingo wa mankhwala. Muzochitika zotere, kutsimikiza kwa ntchito za KFK kungalimbikitsidwe, ngakhale kuti chiwongolero chotere sichimalepheretsa kukula kwa myopathy.

Mukamagwiritsa ntchito mankhwala Atorvastatin, komanso mankhwala ena a mkalasiyi, milandu ya rhabdomyolysis yolephera kupweteka chifukwa cha myoglobinuria imafotokozedwa. Mankhwala a Atorvastatin ayenera kusiyidwa kwakanthawi kapena kulekeka kwathunthu ngati pali zizindikiro za myopathy zotheka kapena ngati pali zovuta zomwe zingachitike chifukwa cha kukanika kwa impso chifukwa cha rhabdomyolysis (mwachitsanzo, matenda opweteka kwambiri, hypotension ya arterial, opaleshoni yayikulu, kuvulala kwakukulu, metabolic, endocrine ndi electrolyte kusokonekera komanso kukomoka kosalamulirika) .

Musanayambe mankhwala ndi Atorvastatin, ndikofunikira kuyesa kuthana ndi hypercholesterolemia mwa kudya mokwanira mankhwala, zolimbitsa thupi, kuchepa thupi kwa odwala omwe ali ndi kunenepa kwambiri komanso kuthandizira zina.

Odwala akuyenera kuchenjezedwa kuti ayenera kupita kwa dokotala ngati vuto lopanda kufooka kapena kufooka kwa minofu kumachitika, makamaka ngati akuphatikizidwa ndi malaise kapena malungo.

Kukopa pa kuyendetsa magalimoto ndi kayendedwe kazinthu

Zotsatira zoyipa za mankhwala a Atorvastatin pa kuyendetsa galimoto ndikugwira ntchito ndi zida sizinanenedwe.

Mawonekedwe ndi kipimo

Atorvastatin (m'Chilatini - Atorvastatin) imapezeka pokha piritsi. Pofuna kupewa zovuta za chilengedwe (chinyezi, kuwala, kutentha) pazinthu zomwe zimagwiritsidwa ntchito ndi mankhwalawo, komanso kuyamwa kwa mankhwalawa m'magawo am'mimba ndi gawo loyambirira la matumbo, amakutidwa ndi membrane wamafilimu. Mtundu wa filimuyo umatengera wopanga. Nthawi zambiri chimakhala choyera, koma nthawi zina chimakhala chikaso, chofiirira kapena chofiirira. Maonekedwe ndi mawonekedwe a mapiritsiwo ndi osiyana: ndiwazungulira kapena wozungulira kapangidwe kake, wokhala ndi mawonekedwe osalala kapena wolemba manambala mbali zosiyanasiyana.

Koma chinthu chachikulu mu mankhwalawa si mawonekedwe, koma ntchito yogwira. Ichi ndi atorvastatin calcium calcium. Koma popeza zomwe atorvastatin imachita imakhala ndi gawo lalikulu pokwaniritsa njira yothandizira achire, mlingo wa mankhwalawo umayang'aniridwa makamaka kwa iwo. Chifukwa chake mu internet network mungapeze Atorvastatin wokhala ndi 10, 20, 30, 40, 60 ndi 80 mg pazomwe zimagwira. Mlingo wake wocheperako (1 kapena 5 mg), ngakhale m'magulu ophatikiza a hypolipidemic, mulibe.

Mu cell imodzi yopanga masamba, mapiritsi 10 kapena 15 amayikidwa. Phale imodzi imatha kukhala mu phukusi, kapena mwinanso - mpaka 10. Mapiritsi ambiri amapezeka mumatumba a polymer. Pali mitundu yina ya mankhwala a gulu ili, yomwe ndi atorvastatin. Koma ali ndi zina, osati zapadziko lonse (INN), koma mayina amalonda (Atoris, Liprimar, Novostat, Tulip, etc.).

Mankhwala oyamba a Atorvastatin opangidwa ku Russia ali m'ndalama zotsatirazi:

• makina a anatomical and achire mankhwala gulu (ATX) ndi C10AA,
• nambala molingana ndi gulu la ku Russia lochita bwino OKPD2-20.10.149,
• malinga ndi kaundula wa mankhwala aku Russia (RLS), mankhwalawo ndi a gulu la mankhwalawa "statins".

Atorvastatin sichinthu chokhacho chomwe amapangira mankhwalawa. Muli zotuluka: calcium carbonate, cellulose, mkaka, wowuma, silicon dioxide, magnesium stearate, polyvinyl mowa, titanium dioxide, polyethylene glycol ndi talc. Odwala matendawa ayenera kudziwa za iwowa, chifukwa momwe mankhwalawa angapangidwire.

Atorvastatin amapezeka pamankhwala omwe adotolo amauza Latin. Ndipo ngakhale azamankhwala osavomerezeka ali okonzeka kugulitsa mankhwalawo, simuyenera kumwa popanda kufunsa dokotala. Inde, musanalandire chithandizo komanso munthawi yake ndikuyenera kuwongolera chiwindi.

Zizindikiro zogwiritsidwa ntchito

Zomwe zimakhazikitsidwa ndi ma statins zimatchedwa dyslipidemia. Omasuliridwa chilankhulo chosavuta, ichi mafuta kagayidwe. Siziwonekera kwa nthawi yayitali kwambiri, ndipo pokhapokha ndi kuyika kwambiri kwa cholesterol "yoyipa" m'mitsempha ya mtima kumayambitsa zizindikiro za atherosulinotic. Pachigawo choyamba, kusakhazikika kwa lipid kumapezeka mu labotale. Kuwunikaku kumatchedwa mbiri ya lipid, imaphatikizapo zofunikira zazikulu za metabolism yamafuta - triglycerides, cholesterol, onse okwanira komanso gawo lama protein-protein, cholesterol transporter protein, komanso coheroffine ya atherogenic.

Popanda kudziwa mbiri ya lipid (dzina lachiwiri la mbiri ya lipid), ndizosatheka kukhazikitsa mtundu ndi mtundu wa statin, womwe udzatengedwe ndi wodwala kwanthawi yayitali (ndipo mwina, moyo wake wonse). Kuphatikiza apo, mbiri ya lipid ndiyofunikira pakuwongolera chithandizo chomwe chayamba kale. Magazi a Venous amaperekedwa kuti awunike pambuyo pokonzekera kosavuta: popanda icho, zotsatira zake zitha kupotozedwa.

Ubwino wa atorvastatin ndiwothandiza pa mankhwalawa amitundu yonse ya hypercholesterolemia (cholowa komanso cholowa). Amachepetsa cholesterol "yoyipa" komanso mapuloteni onyamula omwe angayikidwe mumakoma a mitsempha. Nthawi yomweyo, imakulitsa kuchuluka kwa lipoprotein "zabwino" ndikukulitsa kuchuluka kwa zolandila zomwe zimagwira cholesterol pakugwiritsa ntchito kapena kugwiritsa ntchito. Kuphatikiza apo, atorvastatin imachepetsa triglycerides m'mwazi, koma sizitanthauza kuti imatha kutengedwa kuti muchepetse kunenepa.

Mphamvu ya zochita za yogwira zimatengera kukakamiza kwa puloteni yayikulu yomwe imathandizira mapangidwe a cholesterol ndi maselo a chiwindi. Enzyme imatchedwa hydroxymethylglutaryl coenzyme A reductase, ndipo Atorvastatin, motsatana, ndi choletsa wa HMG CoA reductase. Ndilo mtundu wa mankhwalawa womwe umalola kuti usangoletsa kukula kwa malo omwe alipo kale atherosulinotic, komanso kuteteza mawonekedwe awo mwa anthu omwe ali pachiwopsezo chotenga atherosulinosis. Chifukwa chake, atha kutumizidwa kuti akhale ndi vuto la majini ku hypercholesterolemia adakali aang'ono kapena kwa osuta kwambiri ndi odwala matenda oopsa pambuyo zaka 55.

Statin samachiza mitsempha yamagazi, koma ndi matenda amtima kapena matenda a mtima zimaletsa zovuta monga kugunda kwa mtima kapena sitiroko. Zisonyezero zagwiritsidwa ntchito ndi mitundu yayikulu ya matenda a mtima, pambuyo pawo, ngozi zapamtima. Atorvastatin amadziwikanso mu postoperative nthawi mu mtima sayansi ndi mtima. Ndipo zotsatira zabwino zimapezeka ndikugwiritsa ntchito zovuta kwa mankhwalawa ndi mankhwala ena otsitsa a lipid komanso kuphatikiza njira zina zowongolera mafuta kagayidwe (zakudya, masewera olimbitsa thupi, kusiya zizolowezi zoyipa).

Pa mimba ndi mkaka wa m`mawere

Kufufuza komwe kunachitika motere sikunachitike, ndipo palibe amene amadziwa momwe Atorvastatin amakhudzira mwana wosabadwayo komanso ngati amadutsa mkaka wa m'mawere. Chifukwa chake, samaperekedwa kwa amayi apakati, ndipo ngati kuli kofunikira kutenga mkaka wotsekera, mwanayo amasinthidwa kuti adyetse maupa. Pankhaniyi, amayi omwe ali ndi zaka zobereka, pamene akutenga statin, tikulimbikitsidwa kugwiritsa ntchito njira zoyenera za kulera kuti zithetse mwayi wokhala ndi pakati pa zero.

Atorvastatin amalembera okhawo akuluakulu, ndipo adapangidwira zochizira matenda a lipid metabolism komanso kupewa mtima wamavuto osagwirizana ndi maziko a mtima opangidwa ndi mtima. Zokhudza kuchuluka kwa ana ndi achinyamata sizimamveka bwino, chifukwa chake madokotala sakhala pachiwopsezo chogwiritsa ntchito odwala omwe ali ndi zaka 18.

Zotsatira zoyipa

Kuopsa kwa zovuta kumakhala kotsika: zotsatira zoyipa zimachitika mu 1-3% ya anthu omwe amagwiritsa ntchito nthawi yayitali atorvastatin.

1. Nthawi zambiri, izi ndi zizindikiro zamitsempha m'mimba.
2. Chifukwa chakuti chinthu chogwira ntchito chimakhudza chiwindi, dyspepsia imatha kukhala - kutulutsa, mseru, kutsegula m'mimba kapena kudzimbidwa, kupweteka pamimba.
3. Nthawi zina pamakhala kupweteka kwakanthawi.
4. Malangizowo amatcha ziwengo (kuyambira pakulowerera pakhungu mpaka anaphylaxis), kuchepa kwa potency, kuphwanya mphamvu ya zotumphukira zamitsempha, kukokana, ndi kupweteka kwapawiri ngati zotsatira zoyipa.
5. Ndizachilendo kwambiri kukhala ndi hepatitis ya mankhwala osokoneza bongo kapena kapamba, kusintha kwa magazi kumachitika: kuchepa kwamapulogalamu, kuwonjezeka kwa michere ya chiwindi.
6. Pazokha, rhabdomyolysis inalembedwa - kuwonongeka kwa minofu minofu yomwe idatsekeka pambuyo pake pamatupa a impso chifukwa cha zinthu zawo zowola, zomwe zimapangitsa kuti pakhale kulephera kwamphumo.

Chisamaliro chapadera chikuyenera kuperekedwa kwa odwala matenda ashuga mitundu yonse iwiri. Matenda a shuga ndi chiwonetsero chovomerezeka cha matendawa. Ndipo izi sizanthu koma kupititsa patsogolo kwa zotupa zamatenda am'mimba. Atorvastatin amalembedwa kwa odwala matenda ashuga pamene dyslipidemia yapezeka. Kodi imakweza shuga? Yankho ndi losamveka: chilichonse ndi chokhacho, mankhwalawa sangakhudze kuchuluka kwa shuga, koma angayambitse hypo- kapena hyperglycemia. Kugwiritsa ntchito mankhwala a statin a mtundu 1 ndi matenda amtundu wa 2 kumaphatikizapo kuwunika kawirikawiri shuga.

Mlingo ndi makonzedwe

Mlingo wa mankhwalawa amatchulidwa ndi dokotala, kutengera mtundu ndi dyslipidemia. Amatsimikizanso kuti njira yamankhwala ingakhale masiku angati kapena miyezi ingapo. Mofananamo, mankhwala amodzi kapena angapo omwe amaperekedwa kuti akhale ndi cholesterol yayikulu, komanso zakudya zochepetsetsa za lipid atatha kumwa, atha kutumizidwa. Katswiri wodziwa bwino amakuphunzitsani kumwa madzi oyera ndikuyenera kuchita masewera olimbitsa thupi.

Komabe, wodwalayo ayenera kudziwa nthawi yatsiku lomwe kuli bwino kumwa mankhwalawa (m'mawa kapena madzulo) kuposa kumwa, kumwa mapiritsi musanadye kapena mutatha kudya.

1. Kukula kwake ndi kuchuluka kwa kuchepetsa kwa cholesterol "yoyipa" m'magazi sikudalira chakudya.
2. Mafuta omwe amagwiritsidwa ntchito m'magazi ndi 30% mwapamwamba ndi mapiritsi a m'mawa, poyerekeza ndi madzulo.Koma, mankhwala oledzera usiku amakhala ndi mphamvu yambiri pachiwindi, chomwe chimagwira ntchito kwambiri usiku. Chifukwa chake, palibe kusiyana pa nthawi yomwe piritsi imatengedwa. Chachikulu ndikuti nthawi yomweyo.
3. Kuti mankhwalawa asamamwe mosavuta kudzera m'matumbo, ndi bwino kumamwa ndi madzi oyera. Ndizotheka ndi china chake, koma osati ndi madzi a mphesa, omwe amalimbikitsa kuyamwa kwa statin ndipo potero amawonjezera kuchuluka kwake m'magazi.
4. Mankhwalawa amayamba ndi Mlingo wocheperako (10 mg), ndipo pakatha milungu iwiri, itatu kapena inayi pamasinthidwe mawonekedwe a lipid. Izi ndichifukwa choti mankhwalawa amayamba kuwonekera pakatha milungu iwiri yokha, mpaka kufika kumapeto kwa mwezi. Malinga ndi mbiri ya lipid, adokotala amawongolera momwe angasinthire mlingo.
5. Mlingo wapamwamba wa Atorvastatin umatengera mtundu wa dyslipidemia, manambala ake oyamba, kukhalapo / kusowa kwa matenda a chiwindi, komanso mgwirizano wama mankhwala a magulu ena. Zimatengera nthawi yayitali kuti mutenge.

Zolemba zogwiritsira ntchito

Asanapereke Atorvastatin, madokotala akuyesera kuti akwaniritse kubwezeretsa kwa lipid moyenera ndi zakudya, zolimbitsa thupi, kuchepa thupi. M'malo mwake, malingaliro awa amapitilira nthawi yonse ya chithandizo cha statin. Nthawi yomweyo musanadye yoyamba ya mankhwala ntchito ya chiwindi. Kenako imakhala yokhazikika: masabata 1.5 pambuyo poyambira mankhwalawa, pambuyo pa miyezi itatu, kenako - miyezi isanu ndi umodzi iliyonse komanso pambuyo pa kusintha kulikonse.

Kuphatikiza apo, mankhwalawa amathandizira odwala matenda obwereza amawunikiranso asanayambe chithandizo. Ndi kuthamanga kwa magazi, hypothyroidism, kunenepa kwambiri, matenda amchiwindi, mankhwala omwe amagwirizana amasankhidwa kapena mlingo womwe umagwiritsidwa ntchito, malingana ndi kufotokozera. Komanso, odwala amachenjezedwa za kuthekera kwa myopathy, chifukwa chake ayenera kudziwitsa dokotala za kupweteka kwa minofu iliyonse.

Maphunziro ochepera Chithandizo sichinapangidwe kwa masiku angapo, ndipo chikhala bola ngati katswiri wanena. Nthawi zambiri ochepera amakhala miyezi ingapo. Kupatula apo, kusagwirizana kwa lipid kunayamba zaka zambiri kapena zaka zambiri. Ndipo zimatengera nthawi yayitali kukonza. Chifukwa chake, funso loti mungathe kupumira panokha siliyenera kukhala: mapiritsi ayenera kuledzera nthawi zonse. Popanda yopuma, Atorvastatin imatha kutengedwa zaka zambiri, ndipo zimatenga nthawi yayitali bwanji kuti achite izi - lipid mbiri imati.

Ndi chiwindi ntchito

Atorvastatin amaloledwa pokhapokha ngati pali chiwindi matenda kapena kufooka kwa chiwindi. Komabe, imawunika kufunika kogwiritsa ntchito kwake komanso kuthekera kwina kusintha njira zina zomwe sizikhudza chiwindi. Kuwunikira magwiridwe antchito a hepatocytes ngati vuto la chiwindi ndilofunikira kwambiri. Kusanthula kuyenera kuchitika pa nthawi komanso mukatha kukonzekera.

Mtengo wa mankhwala

Mankhwala a gulu lama pharmacological amapangidwa m'maiko ambiri, ndipo mtengo wa Atorvastatin umatengera wopanga. Komabe, komanso pamtundu wa milligram, komanso kuchuluka kwa mapiritsi a phukusi. Ma analogues pamtengo akukonzekera kupanga kwa Chiyukireniya, Russia, India ndi Chingerezi.

Mtengo wa maphunziro a pamwezi ndi tsiku lililonse 20 mg m'masamba athu amapangira 90 ± 20 UAH. kapena 250 ± 80 ma ruble. Mapiritsi a Israeli ndi okwera mtengo 1.5, owonjezera ku Spain ndi okwera mtengo kawiri, Amereka ndi aku Germany amakhala okwera mtengo katatu.

Analogs ndi cholowa m'malo a Atorvastatin

Mankhwala oyamba si amtundu umodzi. Kutengera zomwe zimagwira, misa imapangidwa zamagetsi ndi zofananira (mwachitsanzo, Atoris, Atokor, Atormak kapena Atorvok), ndipo nthawi zina zimasiyana kotheratu (Torvakard, Tulip, Vazator), mayina amalonda omwe amasiyana pakapangidwe kazinthu zina. Ena mwa iwo ndi otsika mtengo, ndipo ena ndi otsika mtengo kwambiri. Zitha kusintha m'malo mwa wina ndi mnzake, koma pokhapokha ngati mukudziwa dokotala.

Zomwe atorvastatin-based statin ndizabwinoko

Phukusi lachipatala, nthawi zambiri pafupi ndi dzina loyambirira limakhala ndi chidule kapena mawu ena, mwachitsanzo, Atorvastatin SZ kapena Atorvastatin MS. Izi tinthu timene timapanga opanga osiyanasiyana. Izi, tikulankhula za makampani opanga mankhwala ku Russia Severnaya Zvezda ndi Medisorb. Pazosanjikiza zina mutha kuwona mawu owonjezera "Pranapharm", "Ozone", "LEXVM", "Vertex", "Canonfarm", "Akrikhin", "Actavis", "Biocom", "ALSI Pharma".

Mwa zina zomwe mungapeze mu Atorvastatin Alkaloid (Macedonia), Atorvastatin Teva (Israel), Ananta (India), Pfizer (USA), Blufish (Sweden), Ratiopharm (Germany), " Aveksima "(kampani yapadziko lonse lapansi) ... Ndizosatheka kunena motsimikiza kuti ndi mankhwala ati omwe kampani ndiyabwino. M'malo mwake, izi ndizofananira, fanizo mwachindunji. Madera otchedwa Atorvastatin ali ndi zinthu zomwezo. Amasiyana m'magawo othandizira: mapiritsi amatha kuthandizidwa ndikugwiritsira ntchito omwe alibe zotsatira zoyipa mu regimen yothandizira. Komabe, ngati mankhwala atorvastatin okhala ndi mayina ena ogulitsa.

Izi zikuwonetsedwa ndi kuwunika kwa akatswiri ndi odwala: mankhwala olekeredwa bwino kutengera atorvastatin amasankhidwa kuti akhale odwala, ndipo m'malo mwake sizinakhudze zotsatira za mbiri ya lipid. Koma palibe amene wakwanitsa kusinthiratu mankhwala opanga mankhwala ndi wowerengeka.

Kusiyana pakati pa atorvastatin ndi rosuvastatin, simvastatin ndi lovastatin

Mankhwala omwe akukambiranawa amatanthauza ma statin a m'badwo wachitatu. Pansi pake pamlingo komanso wamkulu mu nthawi yolowa mukuchita zochizira, kupanga fluvastatin, simvastatin wopanga ndi pravastatin, ndi lovastatin wachilengedwe. Othandizira amakono ambiri a hypolipidemic akuphatikizira mankhwala opangidwa a Pitavastatin aposachedwa ndi Rosuvastatin. Kodi pali kusiyana kotani pakati pawo?

Lovastatin imapangidwa pamaziko azinthu zofunikira za bombo la aspergillus. Kupanga kwake kumakhala kovutitsa, kumatenga nthawi yambiri ndipo sikumangonena kuti ndalama zomwe zawonongeka. Zipangizo zomwezi zimagwiritsidwa ntchito popanga Simvastatin ndi Fluvastatin. Ma statins awa ndi opanga mankhwala: ma metabolites awo amachita pakubwera kwa lipid, ndipo osati iwo eni. Chifukwa chake, nthawi inayake imayenera kudutsa zomwe mukufuna zisanachitike. Mosiyana ndi izi, Atorvastatin, Pitavastatin kapena Rosuvastatin ali okonzeka kumenya cholesterol “yoyipa” atangolowa magazi.

Zofananazo ndizofanana ndi kuchuluka ndi kuthamanga kwa chikopa pa thupi: mankhwala a 3 ndi 4 mibadwo ndi othandiza kwambiri (Simvastatin - 2 times, Pravastatin ndi Lovastatin - nthawi 4, Fluvastatin - 8 zina). Komabe, madokotala komanso odwala onse ali ndi chidwi chofuna kuti statin ikhale yotetezeka. Ndipo pomwepo zimatengera mtundu wa mankhwala. Mafuta osungunuka a lovastatin, simvastatin, ndi atorvastatin amalowa mosavuta mu maselo aubongo. Ndipo mavuto obwera chifukwa cha mtima wamanjenje amatha kuposanso madzi osungunuka rosuvastatin, fluvastatin ndi pravastatin. Koma otsirizawa amakhala ndi mphamvu pama cell a chiwindi, omwe amatha kuwonetsedwa ndi kuchuluka kwa michere ya chiwindi m'magazi.

Ngati tikufanizira mankhwala am'badwo waposachedwa ndi mzake, chinthu chachikulu chomwe chimasiyanitsa Atorvastatin ndi Rosuvastatin ndi Pitavastatin sichigwira ntchito bwino (nthawi 2) ndipo, mndandanda wocheperako wazotsatira zoyipa. Kuphatikiza apo, kuchuluka kwa mankhwala amakono kwambiri m'magazi sikukhudzidwa ndi chakudya, pomwe zomwe zili ma statin ena zimatengera nthawi yakudya.

Lovastatin, Simvastatin kapena Atorvastatin, Rosuvastatin: ndani mwa iwo anenedwa bwino ndi adotolo. Koma kuchokera pamawonekedwe a mankhwala ofotokozera, kusankha kunagwera pa ma statins omwe amapangidwa ndi atorvastatin kapena rosuvastatin. Omalizawa akuphatikizapo Rosart, Rosucard, Mertenil, Crestor, Suvardio, Cardiolip ndi ena ambiri. Koma ngati odwala akufuna kumwa mankhwala kokha pamankhwala azitsamba, ndiye kuti chiwongola dzanja (Ateroklefit Evalar) chitha kusintha ma synthetics.

Kugwiritsa Ntchito

Anthu ambiri, asanayambe chithandizo, amafuna kudziwa lingaliro loyima pawokha la madokotala (akatswiri azachipatala), komanso kudziwa za ndemanga za odwala omwe adamwa mankhwalawa. Pambuyo pa kafukufuku wa akatswiri ndi odwala, wina atha kuona mfundo zazikuluzikulu motere:

• Atorvastatin ndi mankhwala osankha madokotala ambiri chifukwa chothandiza kwambiri komanso samakumana ndi mavuto ambiri,
• Odwala ambiri omwe amamwa mapiritsi a cholesterol "yoyipa" akuwoneka kuti akukhala bwino, makamaka omwe amayenera kusintha mbadwo watsopano wa statin ndi rosuvastatin ndi atorvastatin chifukwa cha zotsatira zoyipa zina.
• ochepa mwa odwala omwe amamwa mankhwalawa adadandaula za chizungulire, kufooka ndi mutu, koma awa anali anthu achikulire omwe adalandira mankhwala okwanira.