Thioctic acid

Ma antioxidants ndi zinthu zomwe zimaletsa kukhudzana kwa oxidative. Ma radicals aulere omwe amalimbana ndi njira zambiri zopangira matenda m'thupi. Samalola kukula kwa khansa, matenda amtima. Mwa zina zomwe zili ndi izi ndi acidum thiocticum. Malangizo ogwiritsira ntchito thioctic acid (mawuwa amamasuliridwa kuchokera ku Chilatini) akuti ndichimodzi mwazinthu zochepa chabe zomwe zidachitika pompopazi.

Kugwiritsa

Thioctic kapena lipoic acid ndi pabwino wazinthu zomwe m'mbuyomu zimadziwika kuti ndi zinthu ngati vitamini. Koma ataphunzira mwatsatanetsatane, adasankhidwa pakati pama mavitamini omwe amawonetsa mankhwala. M'mabuku azachipatala, dzina la Vitamini N limapezeka.

Monga antioxidant, thioctic acid imamangirira zopitilira muyeso. Mwa momwe thupi limagwirira ntchito, limafanana ndi mavitamini a gulu B. Thupi limawonetsa kutulutsa ndi kutulutsa hepatoprotective.

Izi polysaccharide ndiye njira yayikulu yosungirako chakumapeto ndi chakudya chamagulu. Imasweka mothandizidwa ndi ma enzyme pamene kuchuluka kwa shuga kumachepa, mwachitsanzo, pakuchita masewera olimbitsa thupi. Acid amachepetsa kuchepa kwamavuto omwe amachititsa kuti matenda ashuga akhale oopsa - zosokoneza pakuyenda kwamanjenje, mtima, ndi mitsempha yamagazi.

Pambuyo makonzedwe, thunthu limatengedwa kuchokera m'mimba thirakiti. Kuzindikira kwakukulu kumawonedwa pakapita mphindi 25 mpaka ola limodzi. Mlingo wa bioavailability kuchokera pa 30 mpaka 60%. Lipoic acid amachotseredwa mu mawonekedwe a metabolites kudzera impso.

Motsutsana ndi Cholesterol komanso Kunenepa kwambiri

Lipoic acid amachepetsa kuchuluka kwa cholesterol yoyipa m'magazi, chifukwa zimatenga gawo mu mafuta kagayidwe ndipo zimathandiza nawo. Hypocholesterolemic zotsatira zimawonekera ngati mavitamini okwanira alowa m'thupi. Mankhwalawa amalepheretsanso kudya. Izi zimalepheretsa kunenepa kwambiri ndipo zimakhazikitsa kulemera kwa thupi.

Mankhwalawa mtima

Mwa kukhalabe ndi kuchuluka kwa thioctic acid mthupi, ndizotheka kuchepetsa mwayi wopezeka ndi mtima, kuphatikizapo mikwingwirima ndi mtima. Odwala omwe amadziwika ndi izi, mankhwalawo amachepetsa zotsatira za matendawa ndikuletsa zovuta zowopsa.

Mankhwala amafulumizitsa nthawi yokonzanso, amathandizira kubwezeretsa mozama ntchito za thupi pambuyo pakugwidwa ndi stroko. Nthawi yomweyo, digiri ya paresis (kufooka kwa ziwalo) ndi kusokonekera kwa machitidwe a minyewa yaubongo kumachepa.

Thioctic acid umagwiritsidwa ntchito pa polyneuropathy (matenda ashuga, mowa), poyizoni, makamaka, ali ndi mchere wazitsulo zolemera, utoto wonenepa. Mankhwala amagwira chiwindi matenda:

• hepatitis A virus, hepatitis aakulu,
• kuchepa kwamafuta,
• matenda ammbuyo.

Vitamini N wakhazikitsidwa kwa hyperlipidemia, wopezeka ndi coronary atherosulinosis, onenepa kwambiri.

Contraindication

Thioctic acid sagwiritsidwa ntchito pazinthu zotsatirazi:

• Hypersensitivity ku lipoic acid kapena zosakaniza zina zomwe ndi mbali ya mankhwala, kuyamwa,
• wodwala sanafike zaka 6, ndi mlingo wa 600 mg - 18 zaka.

Mu neuropathy yayikulu yomwe imayambitsidwa ndi matenda a shuga, thioctonic acid imaperekedwa mwa 300-600 mg. Jekeseni imayendetsedwa ndi jakisoni kapena dontho. Maphunzirowa amatenga masabata 2-2. Kenako fomu yapa piritsi imayikidwa.

Mlingowo umatsimikiziridwa ndi dokotala, yemwe amaganizira kuopsa kwa matendawo ndi momwe wodwalayo alili.

Kutalika kochepa kwambiri kwamankhwala ndi milungu 12. Malinga ndi lingaliro la madotolo, maphunzirowa amapitilizidwa mpaka atakwanitsa zomwe amayembekeza.

Zotsatira zoyipa

Ngakhale mndandanda wazovuta zomwe zimadza chifukwa chogwiritsa ntchito mankhwalawa ndifupikitsa, muyenera kudziwa.

Panthawi yamankhwala, zotere zimachitika:

• Pakulowetsedwa - matenda am'mimba, owonetsedwa ndi nseru, kusanza, chimbudzi, komanso kupweteka kwam'mimba,
• Zizindikiro za Hyperreaction - zotupa pa khungu, urticaria, anaphylactic,
• cephalgia
• kutsika kwa ndende yamagazi,
• ndi mathamangitsidwe a makina a makolo - kukakamizidwa kapena kupuma kwamphamvu, kuwonjezereka kwa chidwi, diplopia - kusokonezeka kowoneka komwe masomphenya owoneka kawiri mumaso, kukokana kwa minofu, magazi, ngati mapulateleti, zotuluka zimafikira ku dermis, mucous membranes.

Mawonekedwe akugwiritsidwa ntchito

Chakudya chimapangitsa kuti ikhale yovuta kuyamwa mankhwalawa. Kuthekera kwa kugwiritsa ntchito thioctic acid pa nthawi ya pakati kumadalira kuchuluka kwa mapindu azimayi ndi kuopsa kwa mwana wosabadwa. Mwambiri, zotsatira za mankhwala pa mwana wosabadwayo sizinakhazikitsidwe ndi FDA.

Popereka thioctic acid, adotolo amawongolera machitidwe a magazi, makamaka kwa odwala matenda a shuga. Pa mankhwala, mowa samachotsedwa pakudya.

Sungani mapiritsi pamtunda wa + 25 ° C, kuteteza ku dzuwa ndi chinyezi. Musatulutse mwayi wosagwirizana ndi ana kwa mankhwalawo.

Kuchita ndi mankhwala ena

Thioctic acid imalumikizana ndi mankhwala ena, omwe angakhudze zotsatira za chithandizo. Zinthu zotsatirazi zikuwonetsedwa:

• Mankhwala amalimbikitsa mphamvu ya kuchepetsa magazi m'magazi ndipo momwemonso amakhudza insulin. Izi zimafuna kusankha mosamala mlingo wa mankhwala a hypoglycemic.
• Yankho la thioctic acid amachepetsa mphamvu ya cisplatin, yomwe imagwiritsidwa ntchito pochiza khansa ya khansa.
• Fomu yamadzi ndi yoletsedwa kugwiritsidwa ntchito nthawi imodzi ndi zida za ringer, dextrose, mankhwala omwe amagwirizana ndi disulfide ndi SH-magulu.
• Kulimbitsa mphamvu yotsutsa-yotupa ya glucocorticoids.
• Mowa wa Ethyl umachepetsa mphamvu ya mankhwalawa.

Bongo

Mankhwala osokoneza bongo amapezeka pafupipafupi. Izi ndichifukwa choti asidi owonjezera omwe amachokera ku chakudya amatulutsidwa mwachangu, popanda kukhala ndi nthawi yovulaza thupi. Ngakhale izi, odwala omwe amagwiritsa ntchito mankhwalawa kwa nthawi yayitali, kugwiritsa ntchito milingo yoposa yomwe akuwonetsa, vutoli likuipiraipira. Madandaulo otsatirawa abuka:

• Hyperacidity ya madzi am'mimba,
• kutentha kwa mtima
• kupweteka m'mimba mwa m'mimba
• mutu.

Mtengo wa thioctic acid umatengera wopanga ndi mtundu wa kumasulidwa kwa mankhwalawo. Mitengo yotsatirayi imagwira ntchito:

• njira yothetsera mtsempha wama mtsempha (5 ampoules, 600 mg) - ma ruble 780.,
• gwiritsani ntchito kukonzekera kwa yankho (30 mg, 10 ampoules) - 419 rub.,
• mapiritsi 12 mg, 50 ma PC. - kuchokera pa 31 rub.,
• 25 mg mapiritsi, 50 ma PC. - kuchokera ku ma ruble 53.,
• Mapiritsi a 600 mg, 30 ma PC. - 702 rub.

Pamaukonde a mankhwala, mankhwala omwe ali ndi yogwira kwambiri thioctic acid amaperekedwa pansi pa mayina awa:

• yankho m'malo a Espa-Lipon (Esparma, Germany),
• yankho mu ampoules Berlition 300 (Berlin-Chemie AG / Menarini, Germany),
• mapiritsi okhala ndi filimu, kulowetsedwa kwa Oktolipen (Pharmstandard, Russia),
• Mapiritsi a Tiogamm (Woerwag Pharma, Germany),
• mapiritsi Thioctacid BV (Meda Pharma, Germany),
• Mapiritsi a Tiolipon (Biosynthesis, Russia),
• Makapisozi a Oktolipen (Pharmstandard, Russia),
• mapiritsi, yankho mu Tielept ampoules (Canonpharma, Russia)

Ma analogu okwera mtengo kapena otsika mtengo amasankhidwa ndi adokotala okha.

Ambiri adakumana ndi zovuta za thioctic acid pazokha. Malingaliro a chida ndichosiyana. Ogwiritsa ntchito ena amawona kuti ndiothandiza, ena amati palibe zotsatira.

Thioctic acid imafalitsidwa m'masitolo osakanizidwa ndi mankhwala. Koma saloledwa kugwiritsa ntchito mankhwalawo pawokha, makamaka ana. Ngati zizindikiro zikuwoneka zofanana ndi zomwe mankhwalawo amupangira, funsani dokotala poyamba kuti muwone chomwe chikuyambitsa matendawo. Ndipo atapezeka mozama, katswiriyo amalemba mankhwala a Thioctic acid. Malangizo ogwiritsira ntchito, omwe amaperekedwa pano, amaperekedwa kuti azidziwa bwino mankhwalawa.

Vitamini N imapezekanso muzakudya, momwe zimakhalira zotetezeka. Akatswiri azakudya amalimbikitsa kudya nthochi, nyemba, anyezi, mkaka, zitsamba, mazira. Chiwerengero cha tsiku lililonse cha thioctic acid kwa munthu wamkulu chimachokera ku 25 mpaka 50 mg. Mwa amayi apakati komanso oyembekezera, kufunika kwake kumawonjezeka, ndikufika pa 75 mg.

Ndemanga za madotolo za thioctic acid

Mankhwalawa ndi osangalatsa malinga ndi ake omwe amatchulidwa kuti antioxidant katundu. Ndimagwiritsa ntchito umuna kwa odwala omwe ali ndi vuto logontha la abambo kuti athane ndi oxidative nkhawa, omwe maoror amatenga nawo chidwi kwambiri. Chizindikiro cha matenda a thioctic acid ndi chinthu chimodzi - matenda ashuga polyneuropathy, koma malangizowo akunenanso momveka bwino kuti "ichi sichifukwa chofooketsa kufunika kwa matenda a thioctic acid."

Kugwiritsa ntchito nthawi yayitali, kumatha kusintha zomverera, kutsitsa chidwi, thrombocytopenia ndikotheka.

Kupanga mankhwala a antioxidant ndikofunikira kwachipatala pofuna kuchiza matenda ambiri a urogenital sphere.

Neuroprotector wapadziko lonse wokhala ndi antioxidant katundu, wogwiritsidwa ntchito nthawi zonse ndi odwala omwe ali ndi matenda osokoneza bongo, komanso odwala polyneuropathies, ndiye kuti ali ndi chifukwa.

Mtengo uzikhala wotsika pang'ono.

Pazonse, mankhwala abwino okhala ndi antioxidant katundu. Ndikupangira kugwiritsa ntchito kuchipatala.

Ndimagwiritsa ntchito njira zovuta za odwala omwe ali ndi matenda ashuga phokoso, mawonekedwe a neuro-ischemic. Kugwiritsa ntchito pafupipafupi kumabweretsa zotsatira zabwino.

Odwala ena sakudziwitsidwa za chithandizo chamankhwala awa.

Odwala omwe ali ndi matenda ashuga ayenera kulandira chithandizo chochepa kwambiri ndi mankhwalawa kawiri pachaka.

Kulekerera kwabwino kwambiri ndi zotsatira zake mwachangu mukagwiritsidwa ntchito kudzera m'mitsempha.

Katunduyo ndi wosakhazikika, amawola msanga mothandizidwa ndi kuwala, chifukwa chake pakaperekedwa kudzera m'mitsempha, ndikofunikira kukulunga botolo la yankho mu foil.

Lipoic acid (mankhwala a thiogamma, thioctacid, berlition, octolipene) amagwiritsidwa ntchito popewa kuthana ndi matenda a shuga mellitus, makamaka matenda ashuga polyneuropathy. Ndi ma polyneuropathies ena (mowa, poizoni) amakhalanso ndi zotsatira zabwino.

Ndemanga za Odwala pa Thioctic Acid

Mankhwalawa adandiwuza kuti ndichepetse kulemera kwa thupi, adandiuza kuti ndiwonjezere 300 mg katatu patsiku, kwa miyezi itatu nditagwiritsa ntchito mankhwalawa khungu langa limatha, masiku anga ovuta adayamba kuvuta, tsitsi langa lidasiya kutuluka, koma kulemera kwanga sikunasunthe, ndipo Izi ndi izi ngakhale ndizotsatira CBJU. Kupititsa patsogolo kolonjezedwa kwa kagayidwe kazakudya, sizinachitike. Komanso, mukamagwiritsa ntchito mankhwalawa, mkodzo umakhala ndi fungo linalake, mwina ammonia, kapena sizikudziwika bwino. Mankhwala anakhumudwitsidwa.

Antioxidant wamkulu. Yotsika mtengo komanso yothandiza. Mutha kutenga nthawi yayitali popanda zotsatira zoyipa.

Ndinaikidwa thioctic acid ndipo ndimamwa piritsi 1 limodzi patsiku kwa miyezi iwiri. Ndili ndi mphamvu yotsatila ya mankhwalawa ndipo malingaliro anga okoma adatha.

Thioctic acid kapena dzina lina ndi lipoic acid. Ndidachita maphunziro a 2 a mankhwala ndi mankhwalawa - woyamba maphunziro a miyezi iwiri mchaka, ndiye pambuyo miyezi iwiri kachiwiri maphunziro awiri miyezi. Pambuyo pa maphunziro oyamba, kupirira kwa thupi kumakhala bwino (mwachitsanzo, maphunziro asanachitike, ndikanatha kuchita ma squats 10 osapumira, pambuyo pa maphunziro a 1 kale 20-25). Kulakalaka kunachepa pang'ono ndipo zotsatira zake, kuchepa kwa thupi kuchoka pa 120 mpaka 110 makilogalamu m'miyezi itatu. Nkhopeyo inayamba kupinki, mthunzi wa ashen unatha. Ndinkamwa mapiritsi 2 nthawi 4 patsiku pa ndandanda pafupipafupi (kuyambira 8 koloko maola 4 aliwonse).

Kufotokozera kwapfupi

Thioctic acid ndi kagayidwe kazinthu kamene kamayendetsa kagayidwe kazakudya ndi mafuta. Malangizo ogwiritsira ntchito mankhwalawa amapereka chidziwitso chimodzi - matenda ashuga polyneuropathy. Komabe, ichi sichiri chifukwa chonyozera kufunikira kwa matenda a thioctic acid machitidwe azachipatala. Ma antioxidant am'mbuyomu amatha kukhala ndi mphamvu yomanga zida zotsalira zaulere. Thioctic acid imatenga gawo limodzi pama cell metabolism, imagwira ntchito ya coenzyme mu tinthu timene timatulutsa timadzi tating'onoting'ono tomwe timateteza khungu ku ma free radicals. Thioctic acid imapangitsa zochita za insulini, zomwe zimagwirizanitsidwa ndi kuyambitsa kwa kugwiritsira ntchito shuga.

Matenda oyambitsidwa ndi vuto la endocrine-metabolic akhala ali m'malo aza madokotala kwazaka zopitilira zana. Kumapeto kwa zaka za ma 80 za zana lomaliza, lingaliro la "insulinelane syndrome" linayambitsidwa koyamba mu mankhwala, komwe, kuphatikiza insulin, kulekerera shuga, kuchuluka kwa cholesterol "yoyipa", kutsika kwa cholesterol "yabwino", komanso kunenepa kwambiri ndi matenda oopsa. Matenda a insulin kukana ali ndi dzina lofanana "metabolic syndrome". Mosiyana ndi izi, akatswiri azachipatala adapanga njira zoyambira za kagayidwe kachakudya koyeserera maselo, ntchito yake yofunika yokhudza thupi, yomwe ndi njira yothandizila kwa thupi lonse. Metabolic therapy imakhudzana ndi mankhwala a mahomoni, kukhalabe ndi mtundu wocheperako wa cholera ndi ergocalciferol (mavitamini a gulu D), komanso chithandizo chofunikira ndi mafuta acids, kuphatikizapo alpha lipoic kapena thioctic. Pankhaniyi, ndikulakwa kwambiri kuganizira za antioxidant mankhwala omwe ali ndi thioctic acid pokhapokha pochiza matenda a shuga.

Monga mukuwonera, mankhwalawa ndi gawo lofunikira kwambiri pa metabolic therapy. Poyamba, thioctic acid amatchedwa "Vitamini N", kutanthauza kufunika kwake kwamanjenje. Komabe, momwe amapangidwira, mankhwala awa si mavitamini. Ngati simunayesere kulowa "m'nkhalango" ya biochemical pofotokoza za ma dehydrogenase maofesi ndi kayendedwe ka Krebs, ziyenera kudziwika kuti katundu wa antioxidant wa thioctic acid, komanso kutenga nawo gawo pokonzanso ma antioxidants ena, mwachitsanzo, vitamini E, coenzyme Q10 ndi glutathione. Kuphatikiza apo: thioctic acid ndiwothandiza kwambiri kuposa ma antioxidants onse, ndipo ndizomvetsa chisoni kuti anthu ena sanazindikirepo za kufunika kwake kogwiritsa ntchito mankhwalawa, komanso ndizochepa, monga momwe tatchulira kale, kokha ku matenda am'mimba. Neuropathy ndikusintha kwa minyewa yoipa, komwe kumayambitsa kusokonezeka kwamitsempha, zotumphukira komanso zotupa komanso kuperewera kwa ziwalo zosiyanasiyana. Tizilombo tonse ta mitsempha timakhudzidwa, kuphatikiza ndi ma receptor. Pathogenesis ya neuropathy nthawi zonse imagwirizanitsidwa ndi njira ziwiri: kuphwanya mphamvu kagayidwe kazinthu ndi kupsinjika kwa oxidative. Popeza "tropism" yotsirizira minofu yamanjenje, ntchito ya dokotala sikuti ndikungodziwa bwino za zizindikiro za neuropathy, komanso chithandizo chake chogwira ntchito ndi thioctic acid. Popeza chithandizo (makamaka, ngakhale kupewa) kwa neuropathy ndichothandiza kwambiri ngakhale isanayambike zizindikiro za matendawa, ndikofunikira kuyamba kumwa mankhwala a thioctic posachedwa.

Thioctic acid imapezeka m'mapiritsi. Mlingo umodzi wa mankhwalawa ndi 600 mg. Popeza synergism ya thioctic acid ku insulin, ndi munthawi yomweyo kugwiritsa ntchito mankhwalawa, chiwopsezo cha hypoglycemic cha insulin ndi piritsi hypoglycemic chingadziwike.

Kutulutsa Fomu

Mapiritsi, omwe amaphatikizidwa ndi utoto kuchokera wachikasu kupita ku chikasu chobiriwira, amakhala ozungulira, biconvex, pakuwonekeratu kuti pakati ndipakati wachikasu kapena wachikasu.

Omwe amathandizira: microcrystalline cellulose 165 mg, lactose monohydrate 60 mg, croscarmellose sodium 24 mg, povidone K-25 21 mg, colloidal silicon dioxide 18 mg, magnesium stearate 12 mg.

Zomwe zimapanga utoto wa kanema: hypromellose 5 mg, hyprolose 3.55 mg, macrogol-4000 2.1 mg, titanium dioxide 4,25 mg, quinoline chikasu utoto wa 0 mg.

Ma PC 10 - matumba otumphuka (aluminium / PVC) (1) - mapaketi a makatoni.
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Mukamwa, pakamwa limodzi ndi 600 mg.

Mu / mu (kutsika pang'onopang'ono kapena kukapumira) imayendetsedwa 300-600 mg / tsiku.

Zotsatira zoyipa

Pambuyo iv makonzedwe, diplopia, zopweteka, zotupa zotupa mu mucous nembanemba, khungu kuwonongeka ntchito n`zotheka, ndi mwachangu makonzedwe, kuwonjezeka intracranial anzawo.

Mukaperekera, zizindikiro za dyspeptic ndizotheka (kuphatikiza mseru, kusanza, kutentha kwa mtima).

Mukamwa pakamwa kapena iv, thupi lawo siligwirizana (urticaria, anaphylactic mantha), hypoglycemia.