Momwe mungagwiritsire ntchito mankhwala Ofloxin 200?

Amapezeka mumitundu yosiyanasiyana - yolimba, yamadzi, yofewa. Ili ndi njira zingapo zogwiritsira ntchito. Chomwe chimagwira ntchito zamitundu yonse ndi chaloxacin, quinolone wa m'badwo wachiwiri.

Ofloxin 200 ndi mankhwala ochokera pagulu la fluoroquinolones, wothandizira pakuwonetsa antimicrobial.

Chophimbidwa ndikumakhala ndi magwiritsidwe osiyanasiyana a mfundo yogwira ntchito. Mapiritsi a Ofloxin, kuphatikiza pa mankhwala othandizira ofloxacin (200 ndi 400 mg aliyense), ali ndi zina zowonjezera:

• shuga mkaka
• wowuma chimanga
• talcum ufa
• hypromellose 2910/5.

Mapiritsiwa amakhala ndi zokutira ndipo zimakhala ndi mfundo zingapo zogwira ntchito.

Mapiritsi amasiyana mosiyanasiyana ndi kusindikiza kosonyeza kuchuluka kwa zinthu zazikulu (200 ndi 400 mg iliyonse). Bokosi lililonse lili ndi matuza 1 okhala ndi mapiritsi 10.

Makutu amaso ndi amaso akupezeka. 1 ml yankho lomveka bwino lili ndi:

• 3 mg ofloxacin,
• mchere njira
• benzalkonium chloride,
• hydrogen chloride
• madzi okonzedwa.

Atakulungidwa mu botolo la pulasitiki ndi dontho.

Ofloxin 200 imapezeka mu mawonekedwe a makutu amaso ndi amaso.

Ilibe njira yotulutsidwa.

Njira yothetsera kulowetsedwa kwamtundu wobiriwira wachikasu ndikuyiyika mu mbale 100 ml. Botolo ili ndi 200 mg yofunikira ndi zotuluka:

• mchere njira
• Trilon B
• hydrogen chloride
• madzi okonzedwa.

Makapisozi achikasu a gelatin okhala ndi kapu yofiirira yofiirira:

• ofloxacin - 200 mg,
• hypromellose
• sodium lauryl sulfate,
• shuga mkaka
• calcium phosphate bisubstituted owonjezera madzi,
• talcum ufa.

Makapisozi a gelatin achikasu amakhala ndi matuza 10 zidutswa.

Makapisozi amadzaza matuza a zidutswa 10.

Mankhwala amapezeka wofatsa - mafuta ogwiritsira ntchito mabala (Oflokain) ndi mafuta am'maso atagona thumba la conjugate. Mafuta amaikidwa m'matumba a 15 kapena 30 g. Mu 1 g ya mankhwala ili:

• 1 mg ofloxacin
• 30 mg ya lidocaine wa hydrochloride,
• propylene glycol
• poloxamer
• macrogol 400, 1500, 6000.

Mafuta amaso amapangidwa m'matumba a 3 ndi 5 g, omwe ali ndi:

Mankhwala amapezeka wofatsa - mafuta okuthandizira mabala ndi mafuta am'maso atagona thumba la conjugate.

Ma suppositories anyama akupezeka pansi pa mayina osiyanasiyana.

Zotsatira za pharmacological

Mphamvu ya bactericidal ya Ofloxin 200 imatheka chifukwa cha kuletsa kwa DNA-gyrase - ma enzymes omwe amayambitsa kapangidwe ka DNA m'maselo a bakiteriya ndi kubereka kwawo. Ma enzymewawa amatenga mbali ziwiri mwanjira zofunika kwambiri - kuzungulira ndikuwonetsetsa kuti khola lake likukhazikika. Fluoroquinolone amathandizira kuwonongeka kwa nembanidwe kabakiteriya, motero, chiwopsezo cha mitundu yosagonjetseka ndiyotsika.

Mankhwala omwe amagwiritsidwa ntchito kwambiri polimbana ndi mabakiteriya opanda gramu. Cholinga cha Ofloxin 200 pomwe adadziwonetsera ndi topoisomerase II. Pakati pagulu la fluoroquinolones, mankhwalawa amayimira ntchito yake motsutsana ndi gramu-cocci. Cholinga chake ndi topoisomerase IV.

Mankhwala omwe amagwiritsidwa ntchito kwambiri polimbana ndi bakiteriya wopanda gramu.

Pharmacodynamics ya chinthu imakhazikitsidwa pakuwonongeka kwa kulumikizana pakati pamagetsi a DNA (kukhazikika kwa izo), komwe kumayambitsa kufa kwa khungu la bakiteriya. Kusankha kotero kunapangitsa kutchuka kwa ofloxacin ndi ma fluoroquinolones ena - mabakiteriya ambiri omwe amalimbana ndi mitundu inanso ya maantibayotiki ndi sulfonamides amalola kuwonongeka kwawo.

Mankhwala ali ndi zoperewera zochepa, monga imagwira ntchito pamtundu wa maselo a bakiteriya, popanda kuwononga kapangidwe ka DNA ya munthu. Chifukwa chake, mankhwalawa amagwiritsidwa ntchito muzochita za ana ndi zamankhwala.

Pharmacokinetics

Mankhwalawa amatengedwa mwachangu komanso mwamphamvu m'matumbo, mpaka kufika pozizira m'magazi pambuyo pa maola atatu ndi atatu. Zakudya pang'ono zimalepheretsa kuyamwa, koma sizikhudza kukwana kwake. Mankhwalawa ali ndi imodzi mwazigawo zapamwamba kwambiri za digestibility pakati pa fluoroquinolones - pafupifupi 100%.

Mankhwalawa amatengedwa mwachangu komanso mwamphamvu m'matumbo, mpaka kufika pozizira m'magazi pambuyo pa maola atatu ndi atatu.

Hafu ya moyo wake ndi maola 5-10, kotero mankhwalawa amatha kumwa kamodzi pa tsiku. Kuzungulira kwa zinthu mu minofu ndizofanana kapena kukwera kuposa seramu. Ngati mlingo waukulu wa mankhwalawo waperekedwa, ndiye kuti chinthucho chimadziunjikira:

• Pakati mantha dongosolo
• machubu bronchial
• thumba lamanja
• dongosolo la urogenital
• mkati mwa chitetezo chathupi.

Chifukwa cha izi, mankhwalawa amagwira ntchito mankhwalawa matenda a intracellular. Ofloxacin amapitilira gawo losintha mthupi - 75-90% ya thunthu limachotsedwa mkodzo, komwe ndikofunikira pakukonzekera kwa matenda a impso ndi kwamkodzo thirakiti.

Thupi lomwe limayenda m'madzi am'magazi silikhala ndi mapuloteni ndipo limalowa mu bedi lamitsempha.

Thupi lomwe limayenda m'madzi am'magazi silikhala ndi mapuloteni ndipo limalowa mu bedi lamitsempha. Mankhwalawa ndi osiyana:

• ntchito iliyonse pH
• kusowa kwamphamvu pa pharmacokinetics of methylxanthines,
• kupezeka kwa zotsatira za postantibiotic,
• kuchepa kwapadera kwa dysbiosis,
• mbiri yabwino yachitetezo.

Thupi silikhudzika kwa kukula kwamkati ndi chiberekero cha mwana wosabadwayo.

Zizindikiro zogwiritsidwa ntchito

Chizindikiro cha matenda opatsirana:

• kwamikodzo dongosolo
• Akazi ndi amuna,
• STI
• matumbo
• dongosolo la biliary
• nosocomial ndi postoperative
• mlengalenga
• septicemia ndi bacteremia,
• Pakati mantha dongosolo
• chifuwa chachikulu, khate.

Ofloxin 200 akuwonetsedwa zochizira kwamikodzo matenda.
Ofloxin 200 akuwonetsedwa zochizira matenda am`mapapo matenda.
Ofloxin 200 akuwonetsedwa zochizira matenda abambo.

Mafutawa amagwiritsidwa ntchito pochiritsa matenda a pakhungu, matenda a mano, komanso mankhwalawa.

Contraindication

Malangizo monga contraindication ogwiritsa ntchito Ofloxin 200 akuwonetsa:

• Hypersensitivity
• Mimba ndi kuyamwa
• mankhwala a ana ochepera zaka 18,
• khunyu komanso kukokana
• kukhalapo kwa kuwonongeka kwa tendon chifukwa chogwiritsa ntchito fluoroquinolones,
• cytosolic enzyme akusowa (G6FD).

Ofloxin 200 ndi contraindicated vuto la hypersensitivity.
Ofloxin 200 ndi contraindicated mu mkaka wa m`mawere.
Ofloxin 200 imaphatikizidwa kwa ana osakwana zaka 18.

Ndi chisamaliro

Mosamala:

• matenda amiseche,
• zovuta zamagazi muubongo,
• kuwonongeka kwaimpso,
• zovuta zamagulu chitukuko ndi chikhalidwe cha chapakati mantha dongosolo,
• kugunda kwa mtima kugundana ndi kutalika kwa gawo la QT.

Zophwanya zambiri zidawunikiridwa.

Kuchenjeza mankhwalawa amalembera zovuta zamagazi muubongo.
Mankhwala osamala ndi mankhwala operewera aimpso.
Chenjezo limawonetsedwa pakulephera kwa mtima ndi nthawi yayitali ya QT.

Momwe mungatenge Ofloxin 200

Odwala achikulire amapatsidwa 200-600 mg. Kutalika kwa maphunzirowa ndi masiku 7-10. Mankhwala osokoneza bongo a 400 mg akhoza kumwa kamodzi, makamaka m'mawa kwa theka la ola kapena ola limodzi musanadye, mlingo waukulu umagawidwa pawiri. Ndikulimbikitsidwa kumeza mapiritsi ndi madzi. Mu matenda akulu ndi kunenepa kwambiri, kuchuluka kwa mlingo mpaka 800 mg / tsiku ndikuloledwa.

Ngati matenda otupa a m'munsi kwamikodzo dongosolo (prostatitis, cystitis, urethritis) sakhala ovuta, ndiye kuti ndikokwanira kumwa 200 mg 1 nthawi patsiku kwa masiku 3-5. Zochizira matenda a chinzonono, limodzi la 400 mg limalimbikitsidwa.

Mlingo ndi njira yothandizira odwala omwe ali ndi vuto la impso zimadalira chilolezo cha creatine: