Oktolipen wa matenda ashuga a 2

Kubereka ndi kuyamwa kutenga Oktolipen sikofunikira.

Malinga ndi malangizowo, Oktolipen pa nthawi yomwe ali ndi pakati amatsutsana chifukwa chosowa chidziwitso chokwanira chachipatala chogwiritsa ntchito thioctic acid panthawiyi.

Munthawi yophunzira zoopsa za ulele, zoopsa zokhudzana ndi kubereka ndi zovuta zomwe zimachitika chifukwa cha mankhwalawa sizinadziwike.

Kuyanjana kwa mankhwala osokoneza bongo

Kuti mankhwalawa akhale opindulitsa, muyenera kuganizira zotsatirazi:

Oktolipen amathandizira zotsatira za othandizira a hypoglycemic and insulin,
tikamwa pamodzi, mankhwalawa amachepetsa mphamvu ya Cisplatin,
Zokonzekera zomwe zimakhala ndi chitsulo, magnesium kapena calcium ziyenera kumwedwa isanachitike kapena itatha Oktolipen ndi malire a maola angapo,
mankhwalawa amalimbikitsa mphamvu za anti-yotupa zama glucocorticosteroids,
mothandizidwa ndi mowa, mphamvu ya Octolipen imatsika.

Pankhaniyi, ndikofunikira kusintha mlingo wa mankhwalawa ndikukhala ndi nthawi yoyikidwa. Ngakhale ndibwino kupewa kuphatikiza mankhwalawa ndi njira zosayenera.

Nthawi zina odwala amakana kumwa mankhwalawa ndipo amapemphedwa kuti asankhe motchipa zotsika mtengo. Nthawi zina, m'malo amafunika chifukwa cha vutoli.

Mankhwala osokoneza bongo amaphatikizapo:

Thiogamma ndi chida chomwe chimathandizira kukhazikika pamachitidwe a metabolic. Dziko lomwe lidachokera mankhwalawa ndi Germany. Amapangidwa monga:

mapiritsi
kulowetsedwa njira (mu dontho),
yang'anani pa kupanga njira yothetsera kulowetsedwa (jakisoni amapangidwa kuchokera ku ampoule).

Mapiritsiwo ali ndi chinthu chachikulu - thioctic acid, mu kulowetsedwa - mchere wa meglumine wa thioctic acid, komanso pakukhazikika kwa infusions - meglumine thioctate. Kuphatikiza apo, mtundu uliwonse wa mankhwalawo umakhala ndi zigawo zosiyanasiyana zothandizira.

Thioctic acid (dzina lachiwiri ndi alpha lipoic) ndi antioxidant wopangidwa mthupi. Imachepetsa shuga m'magazi ndikuwonjezera glycogen m'chiwindi, chomwe, chimapambana insulin.

Kuphatikiza apo, thioctic acid imayang'anira kagayidwe ka lipids, chakudya ndi mafuta m'thupi. Amasintha ntchito ya chiwindi ndi trophic neurons, imathandizanso thupi la poyizoni.

Ambiri, alpha lipoic acid ali ndi zotsatirazi:

hepatoprotective
kutsika kwa lipid,
hypocholesterolemic,
hypoglycemic.

Pochiza matenda a shuga, alpha-lipoic acid amakhala ndi magazi othamanga, amawonjezera kuchuluka kwa glutathione, chifukwa, pali kusintha kwa ntchito ya mitsempha ya mitsempha.

Thioctic acid imagwiritsidwa ntchito kwambiri popanga zodzikongoletsera: imasenda makwinya pankhope, imachepetsa kukhudzika kwa khungu, amachiritsa zipsera, komanso kufunafuna ziphuphu, ndikufinya pores.

Hypoglycemic zotsatira za Oktolipen zimawonjezeka ngati insulin ndi mapiritsi akukonzekera ofanana nawo amatengedwa nthawi yomweyo. Izi zingayambitse kutsika kwa shuga m'magazi mpaka kutsika kwambiri.

Ngati kugwiritsa ntchito mankhwala paliponse ndikofunikira, ndiye kuti kuyenera kutsagana ndi kuyang'anira kuchuluka kwa shuga. Ngati kupatuka kosavomerezeka kwapezeka, mlingo wa insulin kapena mankhwala ena a hypoglycemic amasinthidwa.

Munthawi ya kumwa mankhwalawa, munthu ayenera kupewa zakumwa zoledzeretsa: mankhwalawa act-lipoic acid amachepetsa motsogozedwa ndi ethyl mowa. Pamaso pa Oktollipen, njira zochizira za chisplatin zimachepezedwanso. Thioctic acid sigwirizana ndi zida za ringer ndi dextrose.

M'pofunika kukana kugwiritsa ntchito nthawi yomweyo ya Oktolipen ndi chitsulo ndi kukonzekera kwa magnesium, komanso kugwiritsa ntchito zinthu zamkaka ndi izo. Ngati Oktolipen atengedwa m'mawa, ndiye kuti kukonzekera ndi zinthu zomwe zimakhala ndi calcium, magnesium ndi chitsulo ziyenera kusiidwa madzulo. Mothandizidwa ndi α-lipoic acid, mphamvu yotsutsa-yotupa ya glucocorticosteroids imatheka.

chisplatin - mphamvu yake imachepetsedwa akaphatikizidwa ndi asidi wa thioctic mu njira yothetsera kulowetsedwa,
m`kamwa hypoglycemic wothandizila, insulin - mphamvu ya mankhwalawa imatheka.
glucocorticosteroids - mphamvu yawo yotsutsa-yotupa imawonjezeka,
Mowa ndi metabolites - achire ntchito za thioctic acid wofooka,
kukonzekera kashiamu, magnesium ndi chitsulo - ndimayendedwe apakamwa pakamwa, ndizotheka kupanga zovuta ndi zitsulo (yopuma pakati pamiyeso ya othandizira awa ndipo Oktolipen ayenera kukhala osachepera maola 2).

Njira yothetsera kulowetsedwa kwa intravenous siyigwirizana ndi mayankho a levulose, glucose, yankho la Ringer, lomwe limakhala ndi mankhwala (kuphatikiza mayankho awo) omwe amakhala ndi magulu a disuffide ndi SH.

Pamene thioctic acid ikalumikizana ndi mamolekyulu a shuga, mankhwala osungunuka ovuta amapangidwa.

Zizindikiro zogwiritsidwa ntchito

Tengani Octolipen molingana ndi malamulo awa:

Kukonzekera kwa piritsi kumagwiritsidwa ntchito pakamwa pokha komanso pamimba yopanda kanthu. Osaperera kapena kutafuna.
Mlingo wodziwika bwino ndi 600 mg, koma ngati ndi kotheka, dokotala amatha kuuchulukitsa.
Kutalika kwa nthawi ya maphunzirowa kumatengera chithunzithunzi ndi zovuta zamankhwala.
Jekeseni uyenera kubayidwa m'mitsempha. Kukonzekera kapangidwe kake, muyenera ma ampoules awiri a mankhwalawa. Amadzipereka mu njira ya sodium chloride.
Mlingo wanthawi zonse mukamagwiritsa ntchito mawonekedwe amadzimadzi ndi 300-600 mg. Kutalika kwazinthuzi kumakhala kosiyana.
Nthawi zambiri, poyambira chithandizo, yankho limagwiritsidwa ntchito (masabata 2-4), kenako wodwalayo amasamutsidwa kupita ku Oktolipen pamapiritsi.

Kusankhidwa kwa milingo kumachitika payekhapayekha. Izi zimakhudzidwa ndi zinthu zambiri, ndipo akatswiri okhawo omwe amawaganizira.

Musanagwiritse ntchito mankhwalawa, muyenera kudziwa zomwe amagwiritsa ntchito. Zowonetsa kugwiritsa ntchito mankhwala a Tiogamm ndi:

Matenda a diabetes a neuropathy ndikuphwanya dongosolo lamanjenje polimbana ndi kuthana ndi mitsempha yamagazi yaying'ono mwa odwala omwe ali ndi matenda a shuga.
Polyneuropathy ndi zotupa zingapo zotsekera mitsempha.
Matenda a chiwindi - hepatitis, cirrhosis, kuchepa kwamafuta.
Kuwonongeka kwa mitsempha mathero chifukwa chomwa mowa kwambiri.
Kuzindikira kwa thupi (bowa, mchere wa zitsulo zolemera, etc.).

Kugwiritsa ntchito mankhwalawa kumatengera mtundu wake wamasulidwa. Mwachitsanzo, mapiritsi (600 mg) amatengedwa pakamwa, popanda kutafuna ndi kumwa ndi madzi, kamodzi patsiku. Njira ya mankhwalawa imatha kuyambira pa 1 mpaka miyezi iwiri, malingana ndi kuopsa kwa matendawa. Kubwereza mankhwalawa kumalimbikitsidwa katatu pachaka.

Kukhazikitsa kwa mankhwala a Thiogamm Turbo kumachitika mwaubwino ndi kulowetsedwa kwa kulowerera. Mbale yomwe ili ndi 600 mg ya yankho, mlingo wa tsiku ndi tsiku ndi 1 ampoule. Mankhwalawa amaperekedwa pang'onopang'ono mokwanira, pafupifupi mphindi 30, kupewa zoyipa zomwe zimakhudzana ndi kulowetsedwa mwachangu kwa yankho. Njira yochizira imatenga milungu iwiri mpaka inayi.

Kuyika kwambiri kwa kulowetsedwa kumakonzedwa motere: 1 ampoule (600 mg) ya kukonzekera kwa Tiogamma imasakanizidwa ndi 50-250 mg ya sodium chloride solution (0.9%). Kenako, osakaniza wokonzeka m'botoloyo amaphimbidwa ndi vuto lotetezera. Kenako, yankho limaperekedwa nthawi yomweyo kudzera m'mitsempha (pafupifupi mphindi 30). Nthawi yayikulu yosungirako yankho lokonzekera ndi maola 6.

Mankhwalawa amayenera kusungidwa m'malo amdima osapezeka kwa ana pamtunda wochepera 25C. Alumali moyo wa mankhwalawa ndi zaka 5.

Mlingo umaperekedwa. Dokotala wokhayo amene angakupatseni chithandizo ndi mankhwalawa, apangire njira yochizira matendawa ndikuwerengera kuchuluka kwa momwe wodwalayo alili.

Pamaso pa matenda angapo omwe amayambitsidwa ndi kuwonongeka kwa minyewa ya minyewa komanso vuto la metabolic, akatswiri amalimbikitsa kutenga Oktolipen. Zisonyezero zogwiritsira ntchito lipoic acid amalola kugwiritsa ntchito mankhwalawa mankhwalawa:

polyneuropathy, matenda ashuga kapena mowa,
insulin kukana mu mtundu 1 ndi mtundu 2 shuga
zamafuta microsis,
aakulu a chiwindi
atherosulinosis
kapamba
cholecystitis.

Thioctic acid, yomwe ndi gawo lalikulu la mankhwalawo, imakhala ndi insulin ngati ikupangitsa kuti shuga izitha mofulumira. Kuyamwa kwake mwachangu, komanso kutseguka kwa mafuta kagayidwe, kumathandizira kuchepetsa thupi, kotero amatha kugwiritsidwa ntchito pakuchepetsa thupi.

Zisonyezero zakugwiritsa ntchito kwa Oktolipen amalimbikitsa kukhala ndi matenda ashuga, chifukwa zimathandizira zochita zake zomwe zimapangitsa insulin yake

Kugwiritsa ntchito antioxidant kumeneku sikuloledwa kwa amayi apakati komanso oyembekezera, komanso ana osaposa zaka 16. Kuletsa kugwiritsa ntchito mankhwalawa kunakhazikitsidwa chifukwa zotsatira zake sizimamveka bwino. Mosamala, muyenera kumwa mankhwalawo madalaivala, chifukwa choopsa cha hypoglycemia.

Fotokozerani mankhwalawa kuchokera m'miyezi umodzi mpaka itatu. Kutalika kwa chithandizo ndi mlingo zimadalira kuopsa kwa matendawa, ndipo amatsimikizika payekhapayekha kwa wodwala aliyense. Kusinthana kwa kulowetsedwa ndi mitundu yamapiritsi kumawonjezera mphamvu ya chithandizo. Oktolipen amapezeka m'mitundu ingapo:

mapiritsi ndi mapiritsi
anaikira yankho mu ampoules.

Mu gawo loyambirira la matenda komanso kuchepa thupi, kudya tsiku lililonse kwa mankhwala a ligic ndikofunikira. Mapiritsi ndi makapisozi amaledzera kamodzi kokha patsiku, mpaka masana. Nthawi yopitilira kumwa mankhwalawa ndi chakudya cham'mawa iyenera kukhala mphindi 25-30. Mlingo wapamwamba wa tsiku lililonse womwe umaloledwa kuthandizira kapena prophylaxis sizidutsa 600 mg.

Drip makonzedwe a Okolipen tikulimbikitsidwa kwa odwala kwambiri polyneuropathy. Amatinso gawo la zovuta mankhwala, poizoni, kuchulukitsa kwa chiwindi matenda ndi m'mimba thirakiti. Njira yothetsera kulowetsedwa imakonzedwa musanayambe makonzedwe, chifukwa mankhwalawa amakhala osokoneza bongo ndipo amachotsa katundu wake pambuyo pakuphatikizana kwa nthawi yayitali.

Njira ya 0.9% sodium chloride imagwiritsidwa ntchito kuchepetsa kukhathamiritsa. Sizoletsedwa kuziphiritsa mu njira ya shuga, chifukwa mukakhudzana nayo, chithandizo chamankhwala chimatha. Njira yotsirizidwa imaperekedwa kudzera mu mtsempha wa magazi, kukhuthala, nthawi 1 m'mawa, njira ya mankhwalawa imakhala mpaka mwezi umodzi. Pa jakisoni imodzi, kuchuluka kwa saline ndi 250 ml, ndikuwonjezeranso ma ampoules awiri a concentrate.

Kwa iwo omwe adalembedwa Octolipen mapiritsi 600 kapena mapiritsi, malangizo omwe angagwiritsidwe ntchito amaphatikizapo kumwa tsiku lililonse m'mimba yopanda theka la ola limodzi asanadye. Kugwiritsa ntchito nthawi yomweyo kumachepetsa mphamvu ya mankhwalawa. Kutafuna ndi kutaya mapiritsi ndi makapisozi sikokwanira.

Mlingo woyenera ndi 1 tabu. (600 mg) nthawi 1 / tsiku.

Khansa ya mankhwala n`zotheka: m`kamwa makonzedwe a mankhwala akuyamba pambuyo 2-4-milungu maphunziro a makolo makutu a thioctic acid. Njira yayikulu yotsatirira mapiritsi ndi miyezi itatu. Nthawi zina, chithandizo chamankhwala cha Oktolipen chikusonyeza kugwiritsa ntchito nthawi yayitali. Nthawi yovomerezeka imatsimikiziridwa ndi dokotala wopita.

matenda ashuga polyneuropathy,
zakumwa zoledzeretsa za polyneuropathy.

Makapisozi, mapiritsi

Makapisozi ndi mapiritsi a Okolipen amatengedwa pakamwa, pamimba yopanda kanthu, theka la ola musanadye kadzutsa, osatafuna komanso osaphula, ndi madzi okwanira.

Mankhwala tikulimbikitsidwa kuti kumwedwa kamodzi patsiku mlingo wa 600 mg (2 makapisozi / piritsi 1). Nthawi zina, kuikidwa kwa chithandizo chamankhwala nkotheka. Pakati pa milungu itatu kapena itatu ya maphunzirowa, asidi wa thioctic amathandizidwa ndi iv-infusions wa mankhwala osokoneza bongo, kenako mapiritsi amatengedwa muyezo.

Kutalika kwa mankhwala kumatsimikiziridwa ndi adokotala. Mapiritsi a Octolipen 600 mg samalimbikitsidwa kwa miyezi yopitilira 3, koma ngati ndi kotheka, monga momwe adanenera dokotala, kugwiritsa ntchito mankhwalawa kumatha kukhala kwakutali.

Malangizo ogwiritsira ntchito Oktolipen

Kukonzekera kulowetsedwa, muyenera kuchepetsa 1 kapena 2 ampoules mu 50-250 ml ya 0,9% sodium chloride solution. Njira yothetsera vutoli imayendetsedwa ndi dontho, kudzera m'mitsempha. Amagwiritsidwa ntchito kamodzi patsiku kwa 300-600 mg kwa masabata a 2-4. Chotsatira, muyenera kusinthira pakamwa pamlomo.

Chogulitsachi chimakhala ndi photosensitivity, zomwe zikutanthauza kuti ma ampoules ayenera kuchotsedwa nthawi yomweyo asanagwiritse ntchito.

Ndikwabwino kuteteza chidebe ndi yankho kuchokera pakuwala nthawi ya kulowetsedwa, mwachitsanzo, kugwiritsa ntchito zojambulazo kapena matumba oteteza. Njira yokhazikitsidwa imasungidwa m'malo amdima ndipo imagwiritsidwa ntchito maola 6 mutakonzekera.

Ngati dotolo adapereka chithandizo cha mankhwala ndi Octolipen, ndikofunikira kulingalira mfundo izi:

mankhwala a lipoic acid angafunike kusintha kwa mapiritsi a mankhwala ena ndi zakudya,
Ngati mankhwalawa akuphatikizidwa ndi kupewa komanso kuchiza matenda ashuga, ndikofunikira kuwunika kuchuluka kwa shuga m'magazi pogwiritsa ntchito glucometer, ndikusintha muyezo wa othandizira a hypoglycemic,
The yogwira pophika mankhwala ali chimodzimodzi pochita ndi mavitamini B, koma si vitamini wowonjezera. Kugwiritsa ntchito mankhwala osakambirana ndi dokotala kumatha kukulitsa mavuto azaumoyo.

Zotsatira za pharmacological

Lipoic acid amapangidwa mkati mwa thupi panthawi yopanga okosijeni a keto acid. Kutha kwake kuthetsa mayankho a metabolic ku insulin kwatsimikiziridwa. Lipoic acid amakhudza mwachindunji chiwindi, chofunikira kwa matenda a shuga a 2.

Mankhwalawa amagwiritsidwa ntchito nthawi zambiri mu kunenepa kwambiri ngati mukupezeka matenda a matenda a shuga a 2 kapena popanda matenda otere.

Lipoic acid amakhudza bwino magwero osungiramo mafuta amthupi. Mothandizidwa ndi asidi awa, malo osungirako mafuta amawonongeka ndipo mphamvu zambiri zimamasulidwa. Kuti muchepetse kunenepa, ndikofunikanso kuwonjezera zochitika zolimbitsa thupi ndikutsatira zakudya zamafuta.

Lipoic acid amatenga chakudya chamafuta, koma amawasamutsa kuti asamangogwiritsa minofu, koma minofu ya minofu, komwe amamugwiritsa ntchito kapena kugwira ntchito ngati minofu. Chifukwa chake, mankhwalawa amagwiritsidwa ntchito kuchepetsa thupi pokhapokha pazakudya ndi masewera.

Kafukufuku wambiri akuwonetsa kuti thioctic acid ilibe mwachindunji anabolic.

Oktolipen bwino amachepetsa kuchuluka kwa lactic acid mu minofu minofu yomwe imapangika pakulimbitsa thupi. Munthu amapeza mwayi wopirira kupsinjika kwachangu komanso kwanthawi yayitali, komwe kumakhudza thanzi la munthu komanso mawonekedwe ake.

Lipoic acid imachulukitsa kukoka kwa glucose ndimaselo a minofu. Chifukwa chake, ngakhale kuphunzitsidwa pang'ono kumapangitsa kuti zinthu ziziwoneka bwino pakumwa tiyi. Tiyenera kudziwa kuti mukamachita masewera olimbitsa thupi, kagayidwe kamaselo m'maselo kamakulitsa kwambiri, ndipo zochuluka zaulere zimatuluka, zomwe sizingasinthidwe ndi lipoic acid.

Contraindication ndi zisonyezo

Oktolipen adalembedwa kwa anthu omwe ali ndi polyneuropathy yokhazikika ya matenda ashuga komanso zidakwa.

Amasonyezedwanso cirrhosis ndi neuralgia, kuledzera ndi mchere wazitsulo zolemera. Anthu omwe ali ndi chidwi chachikulu ayenera kumwa mankhwalawa mosamala.

Mukamagwiritsa ntchito mankhwalawa, zotsatirazi zimakhala zotsatirazi:

kutentha kwa mtima, nseru, kusanza,
kupezeka kwa thupi lawo siligwirizana,
hypoglycemia.

Zizindikiro za bongo ndi:

Ngati mukumwa mankhwala a thioctic acid okwanira 10 mpaka 40 g, mapiritsi oposa khumi a 600 mg, kapena muyezo wa 50 mg wa kilogalamu imodzi ya kulemera kwa ana, ndiye kuti:

Psychotor
kukomoka kwakukulu,
kusokonezeka kwakukulu kwa acid-base balance ndi lactic acidosis,
hypoglycemia (mpaka mapangidwe chikomokere),
pachimake chigoba minofu necrosis,
hemolysis
DIC syndrome
mafupa kuponderezana
kulephera kwa ziwalo zingapo.

Ngati limodzi la mankhwalawo likugwiritsidwa ntchito ndipo mankhwala osokoneza bongo amachitika, kuchipatala mwachangu ndikugwiritsa ntchito njira zozikidwa potsatira mfundo zazikuluzikulu zokhudzana ndi poyizoni mwangozi ndikofunikira. Mutha:

kusanza
natsuka m'mimba
samalani makala.

Chithandizo cha kukomoka kwakukulu, lactic acidosis ndi zotsatira zina zowopsa ziyenera kuchitidwa molingana ndi malamulo a chisamaliro chokwanira komanso kukhala chisonyezo. Sizimabweretsa zotsatira:

hemoperfusion,
hemodialysis
njira zosefera pamene thioctic acid wachotsedwa.

Mtengo ndi fanizo

Mtengo wa Oktolipen sukwera kwambiri. Makapisozi okhala ndi 300 mg ya chinthu chachikuluchi amawononga ma ruble 310.

Mapiritsi a Octolipen 600 mg adzagula pafupifupi ma ruble 640. M'mafakitala, mutha kupezanso alpha lipoic acid yomwe. Zimawononga zochepa - ma ruble 80 okha. Mtengo wa Tiolept ndi ma ruble pafupifupi 600, Tiogamm amawononga ma ruble 200, Espa-lipon - pafupifupi rubles 800.

Njira sizimasiyana pogwira ntchito ndipo zimasinthidwa wina ndi mzake:

Tiolepta
Malipidwe,
Lipothioxone
Alpha lipoic acid,
Tiogamma
Thioctacid
Lipamide
Neuro lipone
Espa lipon
Thiolipone.

Chodziwika kwambiri, tsopano ndi mankhwala a Neyrolipon, ndi njira ina yabwino kwa Oktolipen.

Thioctic acid ilipo mu yankho la Thioctacid, ndipo thioctate trometamol imagwiritsidwa ntchito piritsi lamapiritsi.

Thioctacid ndi metabolic mankhwala omwe amathandiza kuchepetsa mawonetseredwe a matenda ashuga komanso mowa.

antioxidant
achina,
hepatoprotective kwenikweni.

Thioctacid amateteza kagayidwe kachakudya mu thupi, kofunikira mtundu wa 2 matenda ashuga.

Pali mitundu ya mitundu:

Gawo lalikulu la mankhwalawa ndi antioididant amkati. Kupezeka kwa chinthu m'thupi kumapereka:

kuchotsa shuga,
masanjidwe a trophic neurons,
kuteteza maselo ku zochita za poizoni,
kuchepetsedwa chiwonetsero cha matenda.

Antioxidant iyi nthawi zambiri imakhalapo mthupi moyenera, ndipo imathandizira kayendedwe kabwino.

Mankhwala omwe ali mgulu la mankhwala a Thioctacid amachedwa mwachangu komanso mokwanira, ndipo amapukusidwa pang'ono ndi thupi pafupifupi theka la ola. Koma kugwiritsa ntchito mankhwalawa ndi chakudya kumakhudza kuyamwa kwa chinthu chachikulu. Bioavailability ndi 20%.

Kwenikweni, metabolism imakwaniritsidwa ndi oxidation ndi conjugation. Kuchotsa zochuluka za mankhwalawa kumachitika ndi impso. Thioctacid nthawi zambiri amalembera odwala matenda ashuga.

Mankhwala oterewa amathandizidwanso kwa matenda a chiwindi. Mwachitsanzo, mankhwala amathandizidwa ndi:

matenda amatsenga
aakulu a chiwindi
kuchepa kwamafuta,
fibrosis.

Thioctacid imapangitsa kuti ichotse mawonekedwe owopsa omwe amasanduka zitsulo.

Mtengo wa mankhwalawa mu ma ampoules ndi ma ruble 1,500, mapiritsi amatengera 1,700 mpaka 3,200 rubles.

Dziwani zomwe zili bwino: Thioctacid kapena Oktolipen, dokotala wopezekapo angakuthandizeni. Ubwino wa lipoic acid kwa anthu odwala matenda ashuga adzajambulidwa mu kanema munkhaniyi.

Kupanga ndi mawonekedwe a kumasulidwa

Octolipene mu ampoules ndi makonzedwe okonzedwera omwe amakonzekera kukonzekera kwa njira ya mtsempha wama mtsempha. Maonekedwe a zomwe zimatsalira ndikuwonekeratu kuti ndi madzi oyera achikasu.

Mililita imodzi ya mankhwalawa imakhala ndi asidi wokhudzana ndi alpha-lipoic acid okwanira 30 mg, 1 ampoule yomwe ili ndi 300 mg yogwira ntchito.

Zigawo zothandiza: ethylene diamine, disodium edetate, madzi osungunuka.

Kutulutsa mawonekedwe: ma ampoules kuchokera kugalasi lakuda, voliyumu - mamililita 10. Kulongedza - mapaketi okhala ndi makatoni, mumkati umodzi wa ma ampoules asanu.

Komanso, mankhwalawa amaperekedwa m'mitundu inanso - mapiritsi a Oktolipen 300 ndi mapiritsi a Oktolipen 600.

Pharmacokinetics

Mothandizidwa ndi intravenous pakukhazikitsa yankho, ndende yayitali ndi 25-38 μg / ml, AUC ili pafupifupi 5 μg h / ml. V_d - pafupifupi 450 ml / kg.

The yogwira thunthu - thioctic acid limagwera metabolites mu chiwindi kudzera mbali unyolo wa oxidation ndi conjugation. Alpha lipoic acid ndi ma metabolites ake amuchotseredwa ndi impso mu buku 80-90%. Hafu ya moyo ndi mphindi 20-50. Chilolezo chonse cha plasma ndi mamililita 10-15 pamphindi.

Octolipen amalembedwa motere:

matenda ashuga polyneuropathy,
zakumwa zoledzeretsa.

Zotsatira zoyipa

Kugwiritsa ntchito mankhwala kungayambitse mavuto:

thupi lawo siligwirizana - urticaria ndi khungu khothi, mwatsatanetsatane thupi lawo siligwirizana kukula kwa anaphylactic,
mbali ya kagayidwe - kukula kwa zizindikiro za hypoglycemia, zomwe zimalumikizidwa ndi kuyamwa kwa shuga,
mbali yayikulu yamanjenje - kupweteka ndi diplopia (zimachitika kawirikawiri ndi njira yovutikira),
kwa magazi coagulation dongosolo - kuzindikira hemorrhages mucous nembanemba ndi khungu, thrombocytopathy, hemorrhagic zotupa, komanso thrombophlebitis,
ena - kuchuluka kwazovuta zamkati, kuwoneka ngati kumva kuwawa m'mutu, kuvuta kupuma, zizindikiro zofananira ndizotheka ndi kuyambitsidwa mwachangu kwa kulowetsedwa kwapakati.

Zotsatira zoyipa sizimadzokha.

Malangizo apadera

Odwala omwe ali ndi matenda a shuga, kuyang'anira magazi pafupipafupi ndikofunikira, makamaka kumayambiriro kwa chithandizo. Nthawi zina, kuchepetsa mankhwala a hypoglycemic wothandizira amafunikira.

Pa mankhwala, m`pofunika kukana kumwa zakumwa zoledzeretsa, chifukwa Mowa zimachepetsa achire mphamvu ya thioctic acid.

Mankhwala Okhala Pamalo a Pharmacy

Mankhwala ndi mankhwala.

Mtengo wa mankhwala a Okolipen mu ampoules amasiyana ndi ma ruble 400 mpaka 470, mtengo wake umatengera pharmacy yomwe mungagule mankhwalawo, komanso dera.

Mndandanda wa mankhwala Okolipen:

Berlition 600,
Mbale 300,
Espa lipon
Neuroleipone.

Pansipa mutha kusiya ndemanga yanu zamankhwala Oktolipen.

Zolemba zina zofananira:

Oktolipen wa matenda ashuga: malangizo ndi ndemanga: 3 ndemanga

Ndakhala ndikutenga Oktolipen m'mapiritsi kwa zaka zingapo m'maphunziro, ndipo ndikutenga njira yotsatsira kawiri pachaka, matenda ashuga polyneuropathy adalembedwa atapezeka ndi matenda. Mankhwalawa amandithandiza, ndikusangalala ndi zomwe zimachitika. Tsopano ndichita njira yotsatira ya otsalira, mwa njira, Oktolipen wachita thupi langa ndipo mwanjira iyi - kulemera kochuluka kwatsika, chilakolako cha thupi sichili bwino.

Oktolipen adandiwuza pambuyo poti matenda ashuga apereka chitukuko cha matenda ashuga a polyneuropathy. Pambuyo poyambitsa yankho lamkati, ndimakhala bwino, woganiza bwino, wolimba mphamvu. Ndimamva kuti kagayidweko kakukwera, pomwe kuchepa thupi kwambiri. Ndimamwa ndimankhwala a hypoglycemic, koma adotolo adasankha mankhwalawa molondola, chifukwa chake sindimakumana ndi zovuta zina.

Zotsatira zakugwiritsa ntchito mankhwalawa zimadziwika pokhapokha masabata awiri, zinthu zinasintha pang'ono, koma palibe chomwe chidasintha. Mwina mankhwala enaake sagwirizana nane, ndimayang'ana mankhwala ena omwe ali ndi vuto lofananalo.

Kutulutsa mawonekedwe ndi kapangidwe kake

makapisozi: kukula No. 0, opaque, zolimba za gelatin, chikasu, zomwe zili m'mabotolowa ndi wotumbulika wachikasu kapena wachikasu wokhala ndi zotupa zoyera (ma PC 10. m'matumba a chithuza, m'matumba atatu 3 kapena 6),
mapiritsi okhala ndi filimu: biconvex, wotumbulika chikasu kapena chikasu, chowumbirira, mbali imodzi ili pachiwopsezo, pa kink - kuchokera kutalika kwachikasu mpaka chikasu (ma PC 10. M'matumba, pamakatoni 3, 6 kapena 10 ma CD)
gwiritsani ntchito yankho la kulowetsedwa: madzi owoneka bwino obiriwira (10 ml mu chikwanira chagalasi yakuda, ma ampoules 5 mu chithuza chamtundu, pakatundu konyamula 1 kapena 2).

Kupanga 1 kapisozi Okolipen:

yogwira mankhwala: thioctic (α-lipoic) asidi - 300 mg,
zina zowonjezera: pregelatinized starch, magnesium stearate, calcium hydrogen phosphate (calcium phosphate disubstituted), aerosil (colloidal silicon dioxide),
chipolopolo cha kapisozi: utoto wa dzuwa chikasu (E110), quinoline chikasu (E104), gelatin yachipatala, titanium dioxide (E171).

Chipangidwe chimodzi cha piritsi 1 yokutidwa ndi filimu, Okolipen:

yogwira mankhwala: thioctic (α-lipoic) asidi - 600 mg,
zina zowonjezera: hyprolose (hydroxypropyl cellulose), hypertose yotsika-m'malo otsika (otsika-hydroxypropyl cellulose), magnesium stearate, colloidal silicon dioxide, croscarmellose (croscarmellose sodium),
zokutira zamafilimu: Opadry chikasu (OPADRY 03F220017 Yellow) macrogol 6000 (polyethylene glycol 6000), hypromellose (hydroxypropyl methylcellulose), talc, titanium dioxide, dye oxide chikasu (E172), aluminium varnish yozizira pa quinoline chikasu (E104).

1 ml ya Octolipen:

yogwira mankhwala: thioctic (α-lipoic) asidi - 30 mg,
zina zowonjezera: disodium edetate (disodium mchere wa ethylenediaminetetraacetic acid), ethylenediamine, madzi a jekeseni.

Mankhwala

Thioctic acid (α-lipoic acid) imapangidwa m'thupi mkati mwa acid oxidative decarboxylation ya α-keto acid ndipo ndimagulu a antioxidants amkati. Imakhala ndi zomangira zama radicals aulere, zimathandizira kubwezeretsanso kuchuluka kwa glutathione ndikuwonjezera ntchito ya superoxide dismutase, bwino trophic neurons ndi axonal conductor. Pokhala coenzyme ya mitochondrial multenzyme complexes, thunthu limatenga gawo la oxidative decarboxylation ya pyruvic acid ndi asidi α-keto.

Chifukwa cha kukopa kwa mankhwalawa, pali kuchuluka kwa glycogen m'chiwindi komanso kuchepa kwa glucose m'magazi, komanso kuthana ndi insulin. Makhalidwe a biochemical thioctic acid ali ofanana ndi mavitamini a gulu B.

Thupi limasinthasintha lipid ndi carbohydrate metabolism, imayendetsa mafuta a cholesterol, ndikuwonetsa lipotropic, imasintha ntchito ya chiwindi, imawonetsa kusintha kwa kuledzera, kuphatikizapo poyizoni ndimchere wamchere.

Tsatirani njira yothetsera kulowetsedwa

Kuti mupeze yankho la kulowetsedwa, ndikulimbikitsidwa kuti muthane kwambiri ndi 300-600 mg (1-2 ampoules) kuti muthandizidwe mu 50-250 ml ya isotonic sodium chloride solution (0.9%). Yankho lokonzekera liyenera kuperekedwa kamodzi kamodzi patsiku pa mlingo wa 300-600 mg kwa masabata 2-4. Pambuyo pake, amasintha pakamwa.

Popeza Oktolipen amakhudzidwa ndi kuwala, ma ampoules omwe amakhala ndi chidwi amafunika kuchotsedwa pamalowo pokhapokha asanagwiritse ntchito. Panthawi ya kulowetsedwa, ndikofunikanso kuteteza vial ndi yankho lokonzekera kuchokera ku kuwala pogwiritsa ntchito zitsulo za aluminium kapena matumba osayatsa. Njira yotsirizidwa iyenera kusungidwa pamalo otetezedwa ku kuwala, osaposa maola 6 kuchokera tsiku lokonzekera.

Bongo

Zizindikiro za mankhwala osokoneza bongo a thioctic acid akhoza kukhala mavuto otsatirawa: kusanza, nseru, mutu, mavuto akulu mukamagwiritsa ntchito mapiritsi a 6 g (10) mwa akulu ndi oposa 0,05 g / kg yolemetsa mwa ana - kukomoka mwamphamvu, chikumbumtima chamaso, psychomotor kusokonekera, hypoglycemia (mpaka chikomokere), kusokonezeka kwakukulu kwa asidi-maziko ndi lactic acidosis, hemolysis, pachimake mafupa a minofu necrosis, kutsutsana kwa ntchito m'mafupa, kufalitsa intravascular coagulation syndrome (DIC), polyorgan Single kulephera.

Ngati pali kukayikira kwa mankhwala osokoneza bongo a Okolipen, kuthandizira kuchipatala mwadzidzidzi ndi njira zofunikira zomwe zimalimbikitsidwa poyizoni mwangozi zimafunikira, kuphatikizapo kusanza, kupweteka kwam'mimba, kutenga makala oyambitsa, komanso chithandizo chamankhwala. Njira zosefera ndi kukakamizidwa kuthetsa kwa thioctic acid, hemoperfusion ndi hemodialysis sizothandiza. Mankhwala enieniwo sakudziwika.

Mimba komanso kuyamwa

Malinga ndi malangizowo, Oktolipen pa nthawi yomwe ali ndi pakati amatsutsana chifukwa chosowa chidziwitso chokwanira chachipatala chogwiritsa ntchito thioctic acid panthawiyi.

Munthawi yophunzira zoopsa za ulele, zoopsa zokhudzana ndi kubereka ndi zovuta zomwe zimachitika chifukwa cha mankhwalawa sizinadziwike.

Pa yoyamwitsa, mankhwala ndi mankhwala amakwiriridwa, chifukwa palibe deta pakulowerera mkaka wa m'mawere.

Ndemanga za Oktolipen

Ndemanga za Oktolipen ndizabwino. Odwala amati zabwino chifukwa chogwiritsa ntchito mankhwalawa mankhwalawa radiculopathy, matenda ashuga polyneuropathy, komanso hepatoprotector. Malinga ndi ndemanga, mankhwalawa amathandizira kuchepetsa shuga la magazi ndi kunenepa kwambiri. Pali malipoti ambiri omwe odwala amawonetsa kuti zochita za Octolipen sizothandiza kwenikweni poyerekeza ndi momwe anasonyezera Berlition, ndipo mtengo wake umakhala wotsika kwambiri.

Zoyipa za mankhwalawa (makamaka mawonekedwe a mapiritsi) zimaphatikizanso kukulira kwa zoyipa, makamaka zochokera m'mimba.

Mtengo wa Oktolipen m'masitolo ogulitsa mankhwala

Mtengo wa Oktolipen zimatengera mtundu wa mankhwalawa amasulidwe ndipo akhoza kukhala:

Makapisozi a Octolipen 300 mg (ma PC 30 pa paketi iliyonse) - ma ruble a 320-350,
mapiritsi okhala ndi filimu, Oktolipen 600 mg (ma 30 ma PC. pakiti) - ma ruble 650-710,
gwiritsani ntchito kukonzekera kwa kulowetsedwa kwa Oktolipen 30 mg / ml (10 ampoules ya 10 ml) - 400-430 rubles.

Oktolipen: mitengo pamafakitale apakompyuta

Okolipen 300 mg kapisozi 30 ma PC.

OCTOLIPEN 30mg / ml 10ml 10 ma PC. kulowetsedwa njira yang'anani

OCTOLIPEN 300mg 30 ma PC. makapisozi

Oktolipen 30 mg / ml mozama njira yothetsera kulowetsedwa 10 ml 10 ma PC.

Oktolipen 300 mg 30 zisoti

Oktolipen konc.d / inf. 30mg / ml 10ml n10

Oktolipen conco ya inf 30 mg / ml 10 ml 10 amp

Okolipen 600 mg wophatikizira mapiritsi a 30 mg ma PC.

OCTOLIPEN 600mg 30 ma PC. mapiritsi okhala ndi filimu

Oktolipen Tab. p.p.o. 600mg n30

Oktolipen 600 mg 30 mapiritsi

Oktolipen tbl p / pl / o 600mg No. 30

Maphunziro: Yoyamba University State Medical University yotchedwa I.M. Sechenov, wapadera "General Medicine".

Zambiri zokhudzana ndi mankhwalawa ndizofanana, zimaperekedwa pazidziwitso ndipo sizilowa m'malo mwa malangizo ovomerezeka. Kudzipatsa nokha mankhwala kuopsa!

Asayansi ochokera ku Oxford University adachita kafukufuku wambiri, pomwe adazindikira kuti zamasamba zimatha kuvulaza ubongo wamunthu, chifukwa zimapangitsa kuchepa kwa kuchuluka kwake. Chifukwa chake, asayansi amalimbikitsa kuti asachotsere konse nsomba ndi nyama muzakudya zawo.

Mu 5% ya odwala, antidepressant clomipramine amayambitsa kuphipha.

Magawo anayi a chokoleti chakuda ali ndi zopatsa mphamvu pafupifupi mazana awiri. Chifukwa chake ngati simukufuna kukhala bwino, ndibwino kuti musadye zopitilira awiri patsiku.

Pochezera pafupipafupi pakama pofufuta, mwayi wokhala ndi khansa yapakhungu umachuluka ndi 60%.

Malinga ndi kafukufuku, azimayi omwe amamwa magalasi angapo a mowa kapena vinyo pamlungu amakhala pachiwopsezo chotenga khansa ya m'mawere.

Anthu omwe amakonda kudya chakudya cham'mawa nthawi zambiri amakhala onenepa kwambiri.

Matenda osowa kwambiri ndi matenda a Kuru. Oimira okha a fuko la Fore ku New Guinea amadwala naye. Wodwala amafa chifukwa cha kuseka. Amakhulupirira kuti chomwe chimayambitsa matendawa ndicho kudya ubongo wa munthu.

Mankhwala akutsokomola "Terpincode" ndi amodzi mwa atsogoleri ogulitsa, ayi chifukwa cha mankhwala ake.

Ngakhale mtima wa munthu sugunda, amatha kukhalabe ndi moyo nthawi yayitali, monga asodzi aku Norweji a Jan Revsdal. “Galimoto” yake inaimilira kwa maola 4 asodzi atasowa ndikugona mu chisanu.

Amayi ambiri amatha kusangalala mwakuganizira za thupi lawo lokongola pakalilore kuposa kugonana. Chifukwa chake, akazi, yesetsani kuyanjana.

Mabakiteriya mamiliyoni ambiri amabadwa, amoyo ndi kufa m'matumbo athu. Amatha kuwoneka pa kukula kwakukulu, koma ngati atakhala palimodzi, akhoza kukhala mu kapu ya khofi yokhazikika.

Pali ma syndromes osangalatsa kwambiri azachipatala, monga kuphatikiza zinthu. M'mimba mwa wodwala m'modzi wodwala mania uyu, zinthu 2500 zakunja zidapezeka.

Mimba ya munthu imagwira ntchito yabwino ndi zinthu zakunja komanso popanda chithandizo chamankhwala. Madzi am'mimba amadziwika kuti amasungunula ngakhale ndalama.

Mankhwala ambiri poyamba anali ogulitsidwa ngati mankhwala osokoneza bongo. Mwachitsanzo, a heroin adagulitsidwa ngati mankhwala a chifuwa. Ndipo cocaine adalimbikitsidwa ndi madokotala ngati opaleshoni komanso ngati njira yowonjezerera kupirira.

Chiwindi chanu chikasiya kugwira ntchito, imfa imatha pakatha tsiku limodzi.

Polyoxidonium imakhudza mankhwala a immunomodulatory. Imagwira ntchito molumikizana ndi chitetezo chamthupi, potero zimathandizira kukulitsa kukhazikika kwa.