Mapiritsi a Gliformin: Zizindikiro za ntchito, mavuto ndi mawonekedwe a mankhwalawa

Wothandizirana ndi hypoglycemic wothandizila kuchokera pagulu la Biguanide.
Kukonzekera: GLYFORMIN ®
The yogwira mankhwala: metformin
ATX Encoding: A10BA02
KFG: Oral hypoglycemic mankhwala
Nambala yolembetsa: P No. 003192/01
Tsiku lolembetsa: 04/21/04
Mwini reg. ID.: Zomera zamankhwala ndi mankhwala AKRIKHIN OJSC

Kutulutsa mawonekedwe ndi kapangidwe kake

Mtundu wa Gliformin ndi mapiritsi.

Yogwira ntchito ya mankhwala ndi metformin hydrochloride. Kuphatikizika kwake piritsi limodzi kungakhale 500 mg, 850 mg kapena 1 gramu.

Zothandiza pa mapiritsi a 500 mg ndi calcium phosphate dihydrate, sorbitol, povidone (polyvinylpyrrolidone), stearic acid kapena calcium stearate, macrogol (polyethylene glycol). Zidutswa 60 zimagulitsidwa. m'makatoni (6 matumba okhala ndi mapiritsi 10 lililonse).

Zowonjezera za Glyformin 850 mg ndi mapiritsi 1 a gramu ndi wowuma wa mbatata, stearic acid, povidone (polyvinylpyrrolidone). Pa Mlingo uwu, mapiritsi 60 amagulitsidwa. mu zitini za polypropylene.

Mankhwala

Metformin ndi mankhwala amkamwa a hypoglycemic omwe ali m'gulu la Biguanides. Amachepetsa mawonetseredwe a hyperglycemic, ndipo chiopsezo cha hypoglycemia chimachepetsedwa. Mosiyana ndi mankhwala a sulfonylurea, mankhwalawa samalimbikitsa kupanga insulin ndipo samadziwika ndi zotsatira za hypoglycemic akagwiritsidwa ntchito mwa odzipereka athanzi.

Metformin imawonjezera chidwi cha zotumphukira zolandilira ku insulin ndikuthandizira kugwiritsidwa ntchito kwa glucose m'maselo, komanso imalepheretsa gluconeogeneis mu chiwindi ndikulepheretsa mayamwidwe a chakudya m'matumbo. Metformin imayambitsa kupanga kwa glycogen pochita glycogen synthase ndikuwonjezera kuthekera kwamtundu uliwonse wamtundu wama glucose otulutsa.

Glyformin amakhudzanso kagayidwe ka lipid, kuchepetsa kuchuluka kwa triglycerides, otsika osalimba a lipoprotein ndi cholesterol yonse. Poyerekeza ndi momwe mankhwalawo amathandizira ndi metformin, kulemera kwa thupi la wodwalayo mwina sikungasinthe kapena kumachepetsedwa pang'ono.

Pharmacokinetics

Pambuyo pakukonzekera pakamwa, metformin imatengedwa kuchokera m'matumbo am'mimba kwathunthu. Mtheradi wake wa bioavailability umafika 50-60%. Kuchuluka kwazinthu zambiri m'madzi a m'magazi zimafika pafupifupi maola 2,5 pambuyo pa kukhazikitsa ndipo ndi 15 μmol, kapena 2 μg / ml. Mukamamwa metformin ndi chakudya, mayamwidwe ake amachepetsa ndikuchepetsa. Imafalitsidwa mwachangu m'thupi lonse, osagwirizanitsa ndi mapuloteni a plasma.

Metformin imapangidwa pang'ono ndipo imatulutsidwa mkodzo. Chilolezo chake mwa odzipereka athanzi ndi 400 ml / min (omwe ali okwanira 4 kuposa creatinine chilolezo), chomwe chimatsimikizira kukhalapo kwa katulutsidwe kabati yamatumbo. Hafu ya moyo ndi pafupifupi maola 6.5. Ndi kulephera kwa aimpso, zimachulukana, zomwe zimayambitsa chiopsezo cha kukopeka kwa mankhwalawa.

Zizindikiro zogwiritsidwa ntchito

Gliformin ndi mankhwala mankhwala a:

• mtundu II matenda a shuga, pamene mankhwala osagwira ntchito sulfonylureas ndizakudya mankhwala,
• lembani matenda ashuga kuwonjezera pa insulin mankhwala.

Contraindication

Sitikulimbikitsidwa kumwa mankhwalawa ndi:

• wodwala matenda ashuga komanso zabwino
• ketoacidosis,
• matenda opatsirana
• zotupa za chiwindi ndi impso,
• mtima kulephera kapena mtima kulephera,
• pachimake myocardial infaration,
• mkaka wa m'mimba, pakati.

Malangizo ogwiritsira ntchito Glformin (Njira ndi Mlingo)

Monga momwe malangizo a Glformin amagwiritsidwira ntchito, mapiritsi amatengedwa pakamwa. Pankhaniyi, masiku atatu oyamba, odwala amapatsidwa 500 mg mpaka 3 pa tsiku limodzi, nthawi yomweyo kapena akudya. Kenako mlingo umakulitsidwa pang'onopang'ono mpaka 1 g. Nthawi zambiri, mankhwalawa amakonzedwa tsiku lililonse ndi 0,1,2.2 g.

Bongo

Mu nkhani ya bongo zingachitike lactic acidosiszakupha. Cholinga chake chachikulu ndikukula. metformin chifukwa cha kuwonongeka kwaimpso. Kalelo kumayambiriro: kusanza, kusanza, kutsekula m'mimba, kufooka wamba, kutsika kwa kutentha, kupweteka kwam'mimba ndi minofu, kuchepa kwa mavuto, bradyarrhythmia. Kenako kupuma mofulumirachizungulirekusazindikira bwino komanso kukula chikomokere.

Zizindikiro zikaoneka lactic acidosis muyenera kusiya kumwa Gliformin. Kupitanso patsogolo kumachitika kuchipatala, motero wodwala amafunikira kuchipatala, kukhazikitsa ndende ya lactate, kutsimikizira matendawa. Njira zoyenera hemodialysiskuthandiza kuchotsa m'thupi mkaka ndi metformin. Mankhwala owonjezerapo amathandizanso.

Fomu lamasamba a Glyformin, ma CD ndi mankhwala.

Mapiritsi ndi oyera kapena pafupifupi oyera, osalala, okhala ndi bevel ndi notch.

1 tabu
metformin (mu mawonekedwe a hydrochloride)
250 mg
-«-
500 mg

Omwe amathandizira: sorbitol, calcium phosphate dihydrate, polyvinylpyrrolidone (povidone), polyethylene glycol (macrogol), calcium stearate kapena stearic acid.

Ma PC 10 - matumba otumphukira (3) - mapaketi a makatoni.
Ma PC 10 - matumba a matuza (6) - mapaketi a makatoni.
Ma PC 10 - matumba otumphuka (10) - mapaketi a makatoni.
Ma PC 60. - zitini zagalasi lakuda (1) - mapaketi a makatoni.
Ma PC 100 - zitini zagalasi lakuda (1) - mapaketi a makatoni.

Kufotokozera kwa ZOTHANDIZA ZABWINO.
Zonse zomwe zaperekedwa zimangoperekedwa kuti mudziwe bwino za mankhwalawo, muyenera kufunsa dokotala zokhudzana ndikugwiritsa ntchito.

Pharmacological zochita za glyformin

Oral hypoglycemic wothandizila kuchokera pagulu la Biguanides (dimethylbiguanide). Kupanga kwa zochita za metformin kumalumikizidwa ndi kuthekera kwake kuponderezera gluconeogeneis, komanso mapangidwe a mafuta achilengedwe omasuka ndi kukhatikiza kwa mafutawa. Metformin siyimakhudzanso kuchuluka kwa insulin m'magazi, koma imasintha ma pharmacodynamics pochepetsa kuchuluka kwa insulini kuti imasulidwe ndikuwonjezera kuchuluka kwa insulin kuti proinsulin. Cholumikizira chofunikira pakupanga metformin ndicho kukoka kwa glucose komwe kumachitika ndi minofu ya minofu.

Metformin imathandizira kufalikira kwa magazi m'chiwindi ndikuthandizira kusintha kwa glucose kukhala glycogen. Amachepetsa msana wa triglycerides, LDL, VLDL. Metformin imakweza michere yamagazi ya fibrinolytic mwa kuponderezana ndi minyewa yokhala ngati minofu ya plasminogen activator inhibitor.

Mlingo ndi njira ya mankhwala.

Kwa odwala osalandira insulin, masiku atatu - 500 mg katatu kapena tsiku kapena 1 g 2 nthawi / tsiku nthawi yakudya kapena itatha. Kuyambira tsiku la 4 mpaka tsiku la 14 - 1 g katatu kapena tsiku. Pambuyo pa tsiku la 15, mlingo umasinthidwa poganizira kuchuluka kwa shuga m'magazi ndi mkodzo. Mlingo wokonza ndi 100-200 mg / tsiku.

Ndi munthawi yomweyo kugwiritsa ntchito insulin pa mlingo wochepera 40 mayunitsi / tsiku, muyezo wa metformin ndi womwewo, pamene mlingo wa insulin ungachepetse pang'onopang'ono (mwa magawo 4-8 / tsiku tsiku lililonse). Ngati wodwala amalandira zoposa 40 magawo / tsiku, ndiye kuti kugwiritsa ntchito metformin ndi kuchepa kwa insulin kumafunikira chisamaliro chachikulu ndikuchitika kuchipatala.

Zotsatira zoyipa za glyformin:

Kuchokera pamimba yogaya: ndikotheka (nthawi zambiri kumayambiriro kwa chithandizo) mseru, kusanza, kutsekula m'mimba.

Kuchokera ku endocrine system: hypoglycemia (makamaka ikagwiritsidwa ntchito mosakwanira).

Kuchokera kumbali ya kagayidwe: nthawi zina - lactic acidosis (pamafunika kutha kwa chithandizo).

Kuchokera pa hemopoietic dongosolo: nthawi zina - megaloblastic anemia.

Zotsatira zamankhwala:

Aphwanya kwambiri chiwindi ndi impso, mtima ndi kupuma kulephera, pachimake gawo la myocardial infarction, uchidakwa, matenda ashuga, ketoacidosis, lactic acidosis (kuphatikizapo mbiri), matenda ashuga apakati, pakati, kuyamwa, kuchepa kwa thupi.

KULAMBIRA NDI KUDZIPEREKA
Contraindified mu mimba ndi mkaka wa m`mawere.

Malangizo apadera ogwiritsira ntchito glyformin.

Sikulimbikitsidwa kumatenda owopsa, kuchulukitsa kwamatenda opatsirana komanso otupa, kuvulala, matenda opweteka kwambiri, komanso chiopsezo chofuna kuperewera madzi m'thupi.

Osagwiritsa ntchito musanachite opareshoni komanso patatha masiku awiri atachitidwa opereshoni.

Sikulimbikitsidwa kugwiritsa ntchito metformin mwa odwala omwe ali ndi zaka zopitilira 60 ndi omwe akugwira ntchito zolimbitsa thupi, zomwe zimakhudzana ndi chiopsezo chowonjezeka cha lactic acidosis.

Panthawi ya chithandizo, ndikofunikira kuwunika ntchito yaimpso, kutsimikiza kwa lactate zomwe zili mu plasma kuyenera kuchitidwa osachepera 2 pachaka, komanso mawonekedwe a myalgia.

Metformin itha kugwiritsidwa ntchito limodzi ndi sulfonylureas. Potere, makamaka kuyang'anira kuchuluka kwa shuga m'magazi ndikofunikira.

Kugwiritsira ntchito metformin monga gawo la mankhwala osakanikirana ndi insulin tikulimbikitsidwa kuchipatala.

Kugwirizana kwa Gliformin ndi mankhwala ena.

Pogwiritsa ntchito munthawi yomweyo ndimomwe zimachokera ku sulfonylurea, acarbose, insulin, salicylates, ma inhibitors a MAO, oxytetracycline, zoletsa ACE, ndi clofibrate, cyclophosphamide, hypoglycemic zotsatira za metformin zimatha kupititsidwa patsogolo.

Pogwiritsa ntchito munthawi yomweyo ndi GCS, njira yolerera ya mahomoni pakumwa, adrenaline, glucagon, mahomoni a chithokomiro, zotumphukira zochokera kwa thiazide, diuretics, zotumphukira za nicotinic acid, kuchepa kwa mphamvu ya hypoglycemic ya metformin ndikotheka.

Kugwiritsa ntchito cimetidine mozungulira kungakulitse chiopsezo cha lactic acidosis.

Malangizo ogwiritsira ntchito Glformin: njira ndi mlingo

Mapiritsi a Glyformin amatengedwa pakamwa pakudya kapena akangomaliza, osatafuna, ndi madzi ambiri.

Dokotalayo amapereka mankhwala ndi nthawi ya makonzedwe payekhapayekha, poganizira kuchuluka kwa shuga m'magazi.

Kumayambiriro kwa mankhwalawa, masiku oyambira 10-15, mlingo umatha kukhala 0,5 mpaka 1 g kamodzi patsiku, ndiye, kutengera kuchuluka kwa shuga m'magazi, utha kuwonjezeka pang'onopang'ono. Mlingo wokonza, monga lamulo, ndi 1.5-2 g patsiku, wogawika mu waukulu Mlingo wa 2-3.

Mlingo wambiri watsiku ndi tsiku wa Glformin ndi 3 g.

Kwa odwala okalamba, muyeso wovomerezeka wa mankhwalawa ndi 1 g patsiku.

Pankhani ya kusokonezeka kwakukulu kwa metabolic, mlingo umalimbikitsidwa kuti uchepe, chifukwa chiopsezo cha lactic acidosis chikuwonjezeka.

Zotsatira zoyipa

• Kuchokera endocrine dongosolo: vuto la bongo - hypoglycemia,
• Kuchokera mmimba: kuperewera kwa chakudya, kupweteka kwam'mimba, kusanza, kutsekemera kwazitsulo mkamwa, kutsekula m'mimba, kusanza, kusilira (zizindikirazi ndi njira zoyambira kuchitira chithandizo, kenako mkhalidwe umasintha).
• Kuchokera ku hemopoietic dongosolo: nthawi zina - megaloblastic anemia,
• Kuchokera kumbali ya kagayidwe: ndi chithandizo chokhalitsa - hypovitaminosis B₁₂, nthawi zina, lactic acidosis,
• Thupi lawo siligwirizana: zotupa pakhungu.

Ngati zotsatira zoyipa zimachitika, ndikofunikira kusiya Glyformin kwakanthawi ndikuyang'ana kwa dokotala.

Malangizo apadera

Kuchiza kuyenera kutsagana ndi kuwunika pafupipafupi kuchuluka kwa shuga m'magazi.

Munthawi yamankhwala, maphunziro akuyenera kuchitika miyezi isanu ndi umodzi iliyonse kuti adziwe kuchuluka kwa lactate ndi creatinine m'madzi a m'magazi. Ntchito ya impso imayang'aniridwa mosamala makamaka kwa okalamba. Glyformin sayenera kulembedwa kwa amuna omwe ali ndi mtundu wa creatinine wapamwamba 135 μmol / L, kwa akazi - 110 μmol / L.

Zotsatira zoyipa za m'mimba zitha kuchepetsedwa pogwiritsa ntchito antacid kapena antispasmodics.

Pa mankhwala ayenera kupewa mowa ndi mankhwala okhala Mowa.

Ndi monotherapy, Glformin sikukhudza kuyendetsa magalimoto ndi kugwira ntchito ndi makina.

Pomwe mukutenga Glformin ndi othandizira ena a hypoglycemic, kuphatikizapo insulin, sulfonylureas, ndikofunikira kusamala poyendetsa magalimoto ndikuchita zinthu zoopsa zomwe zimafuna kuthamanga kwa ma psychomotor komanso kuwonetsa chidwi.

Mimba komanso kuyamwa

Kugwiritsa ntchito metformin pa nthawi ya pakati komanso yoyamwitsa kumatsutsana.

Mukakonzekera kukhala ndi pakati, komanso ngati chachitika ndi chithandizo cha Glformin, mankhwalawa amathetsedwa ndipo mankhwala a insulin ndi omwe amapatsidwa.

Sizinakhazikitsidwe ndendende ngati metformin imadutsa mkaka wa m'mawere, kotero Glyformin sayenera kutumikiridwa panthawi yovomerezeka. Ngati kudya kwake ndikofunikira, kuyamwitsa kuyenera kusiyidwa.

Kuyanjana kwa mankhwala osokoneza bongo

Ndikotheka kuwonjezera zomwe Glyformin amagwiritsa ntchito munthawi yomweyo ndi insulin, beta-blockers, sulfonylureas, non-steroidal anti-yotupa, acarbose, monoamine oxidase inhibitors, angiotensin kutembenuza ma enzyme, oxytetracycline, cyclophosphamide, ndi ena.

Mphamvu ya Gliformin itha kuchepetsedwa ikagwiritsidwa ntchito ndi glucagon, glucocorticosteroids, njira zakulera pakamwa, mahomoni a chithokomiro, epinephrine, sympathomimetics, "loop" ndi thiazide diuretics, zotumphukira za nicotinic acid ndi phenothiazine.

Kugwiritsa ntchito pamodzi kwa mankhwala okhala ndi ethanol kumatha kuyambitsa lactic acidosis.

Kuwonongeka kwa Glyformin kumachepetsedwa ndikaphatikizidwa ndi cimetidine, mwayi wopanga lactic acidosis ukuwonjezeka.

Ndi munthawi yomweyo makonzedwe anticoagulants, coumarin zotumphukira, zotsatira zawo amachepetsa.

Mafanizo a Gliformin ndi awa: Glucofage, Glucofage Long, Glukoran, Gliguanid, Dformin, Diaberit, Diabetesosan, Diabexil, Diguanil, Metformin, Melbin, Mellitin, Metiguanid, Modulan, Formmetin.

Ndemanga za Gliformin

Malinga ndi ndemanga ya Gliformin, imagwira ntchito limodzi pokhudzana ndi matenda a shuga komanso matenda osiyanasiyana a metabolic. Komanso, nthawi zambiri amagwiritsidwa ntchito ndi odwala omwe akufuna kuchepetsa thupi, ndipo anthu ena omwe amawagwiritsa ntchito pazifukwa izi amati anatha kuchepetsa thupi komanso kusintha matenthedwe a mahomoni. Komabe, akatswiri ambiri amachenjeza motsutsana ndi kugwiritsa ntchito Glformin kuti muchepetse thupi, ngati palibe umboni wowonetsa izi.

Odwala ena amatchula zotsatirapo zoyipa za mankhwalawa, kuphatikiza mutu, kufooka, matenda osokoneza bongo. Popeza amatha kupereka zotsatira zabwino komanso zoipa mthupi, tikulimbikitsidwa kuti tichite chithandizo chamankhwala mosamalidwa ndi dokotala.

Mtengo wa Gliformin m'masitolo ogulitsa mankhwala

Mtengo woyenerera wa mapiritsi a Glformin 0,5 g m'matangadza a pharmacy ndi ma ruble 86-130 (phukusi lili ndi mapiritsi 60). Mutha kugula mapiritsi mu filimu yamafuta ndi mulingo wa 0,85 ga pafupifupi 191-217 ma ruble, ndi mulingo wa 1 g wa ma ruble 242-329 (phukusi lililonse lili ndi mapiritsi 60).

Gliformin: mitengo pamafakitale opezeka pa intaneti

GLYGHIN 500mg 60 ma PC. mapiritsi okhala ndi filimu

Gliformin 0,85 g mapiritsi okhala ndi mafilimu 60 ma PC.

Maphunziro: Rostov State Medical University, apadera "General Medicine".

Zambiri zokhudzana ndi mankhwalawa ndizofanana, zimaperekedwa pazidziwitso ndipo sizilowa m'malo mwa malangizo ovomerezeka. Kudzipatsa nokha mankhwala kuopsa!

Malinga ndi kafukufuku, azimayi omwe amamwa magalasi angapo a mowa kapena vinyo pamlungu amakhala pachiwopsezo chotenga khansa ya m'mawere.

Malinga ndi asayansi ambiri, mavitamini zovuta ndizothandiza kwa anthu.

Poyesera kuti wodwalayo atuluke, madokotala nthawi zambiri amapita kutali kwambiri. Ndiye, mwachitsanzo, Charles Jensen wina mzaka kuyambira 1954 mpaka 1994. adapulumuka ntchito zopitilira 900 neoplasm.

Pa moyo, munthu wamba amapanga miyala yocheperako yoposa awiri.

Magawo anayi a chokoleti chakuda ali ndi zopatsa mphamvu pafupifupi mazana awiri. Chifukwa chake ngati simukufuna kukhala bwino, ndibwino kuti musadye zopitilira awiri patsiku.

Malinga ndi ziwerengero, Lolemba, chiopsezo cha kuvulala kwammbuyo chimawonjezeka ndi 25%, ndipo chiopsezo chogundidwa ndi mtima - ndi 33%. Samalani.

Kuphatikiza pa anthu, cholengedwa chimodzi chokha padziko lapansi - agalu, omwe ali ndi vuto la prostatitis. Awa ndi abwenzi athu okhulupilika kwambiri.

Mabakiteriya mamiliyoni ambiri amabadwa, amoyo ndi kufa m'matumbo athu. Amatha kuwoneka pa kukula kwakukulu, koma ngati atakhala palimodzi, akhoza kukhala mu kapu ya khofi yokhazikika.

Asayansi aku America adayesera mbewa ndipo adati madzi amadzi amalepheretsa kukula kwa atherosulinosis yamitsempha yamagazi. Gulu limodzi la mbewa limamwa madzi am'madzi, ndipo lachiwiri ndi madzi a mavwende. Zotsatira zake, zombo za gulu lachiwiri zinali zopanda ma cholesterol.

Okonda akapsopsona, aliyense wa iwo amataya 6.4 kcal pamphindi, koma nthawi yomweyo amasinthana mitundu pafupifupi 300 ya mabakiteriya osiyanasiyana.

Anthu omwe amakonda kudya chakudya cham'mawa nthawi zambiri amakhala onenepa kwambiri.

Mwazi wa munthu "umayenda" m'matumbo omwe akukakamizidwa kwambiri, ndipo ngati umphumphu wake waphwanyidwa, amatha kuwombera mpaka 10 metres.

Nthawi yayitali yotsala ndiyotsika ndi yoyipa.

Ku UK, kuli lamulo malinga ndi momwe dokotala wothandizira amatha kukanachita opaleshoni ngati atasuta kapena wonenepa kwambiri. Munthu ayenera kusiya zizolowezi zoipa, kenako, mwina, sangafunikire opareshoni.

Kulemera kwaubongo wamunthu kuli pafupifupi 2% ya kulemera konse kwathupi, koma kumadya pafupifupi 20% ya mpweya womwe umalowa m'magazi. Izi zimapangitsa kuti ubongo wamunthu ukhale wovuta kwambiri kuwonongeka chifukwa cha kusowa kwa mpweya.

Mafuta a nsomba akhala akudziwika kwazaka zambiri, ndipo munthawi imeneyi zatsimikiziridwa kuti zimathandizira kupewetsa kutupa, kuchepetsa ululu wolumikizana, kukonza sos.

Mlingo ndi kayendetsedwe ka Glformin

Monga lamulo, adotolo amakhazikitsa mlingo wa Glyformin payekhapayekha, potengera kuchuluka kwa shuga m'magazi.

Kuchiza nthawi zambiri kumayamba ndi kugwiritsa ntchito 0.5-1 g patsiku. Kutengera mlingo wa glycemia, mlingo umayamba kuchuluka pambuyo masiku 10-15.

Mankhwala omwe amakonzedwa tsiku lililonse ndi mapiritsi awiri a Glformin 1000, omwe amalimbikitsidwa kuti agawidwe ma Mlingo angapo, omwe amachepetsa kuopsa kwa mavuto omwe amabwera ndi kudzimbidwa.

Mlingo wovomerezeka watsiku ndi tsiku ndi mapiritsi atatu a Glformin 1000, komabe, tikulimbikitsidwa kuti anthu achikulire asamapitirire 1 ga mankhwalawa.

Ndi mankhwala osokoneza bongo a Glformin, lactic acidosis imatha kukhala ndi zotsatira zakupha, zizindikiro zoyambirira zomwe zimakhala nseru, kuchepa thupi, kuchepa kwam'mimba, kusanza, kusanza, kupweteka kwam'mimba ndi minyewa, bradyarrhythmia, kuchepa magazi, chizungulire, kusazindikira bwino, kupuma komanso kukula kwa chikomokere. .

Migwirizano ndi magwiritsidwe akusungidwa

Glformin ndi wa mankhwalawa angapo a mankhwala osokoneza bongo a hypoglycemic (mndandanda B) wokhala ndi alumali wolimbikitsidwa omwe amakhala pansi kosungirako (kutentha mpaka 25 ° C):

• Ndili ndi 250 mg ndi 500 mg yogwira ntchito - zaka zitatu,
• Ndi zili ndi 850 mg ndi 1000 mg yogwira ntchito - 2 years.

Malangizo ogwiritsira ntchito mapiritsi

Zisonyezero zogwiritsira ntchito mankhwalawa ndi mtundu wachiwiri wa matenda osokoneza bongo a shuga, pamene kudya mosamalitsa ndi mankhwala a gulu la sulfonylurea alibe phindu. Glyformin imalembedwanso mtundu wa shuga 1 ngati adjunct wa jakisoni wa insulin.

Panthawi yamankhwala, kugwira ntchito kwa impso kuyenera kuyang'aniridwa, pafupifupi miyezi isanu ndi umodzi ndikulimbikitsidwa kuti mupange kusanthula kuti muwone mkaka wa m'magazi.

Mapiritsi amatha kuledzera pakudya kapena mutatha kudya, mlingo woyenera uyenera kutumikiridwa ndi dokotala, poganizira zotsatira za kuyesedwa kwa magazi:

• kumayambiriro kwa mankhwala, mankhwalawa si oposa gramu imodzi patsiku,
• pambuyo masiku 15, kuchuluka kwa ndalama kumachulukitsidwa.

Mulingo woyenera wokonza sayenera kupitilira magalamu awiri patsiku, uyenera kugawidwa moyenera pazigawo zingapo. Anthu odwala matenda ashuga okalamba tsiku lililonse amalimbikitsidwa kuti amwe mankhwala ambiri a gramu imodzi.

Ngati dokotala amupatsa mankhwala a Glformin a matenda ashuga, wodwalayo ayenera kudziwa kuti mapiritsi amatha kuyambitsa zovuta zina mthupi. Kumbali ya endocrine dongosolo, hypoglycemia imayamba, mbali ya magazi, magazi amadzimadzi amatha, pamtundu wa kuperewera kwa metabolism kumachitika. Thupi nthawi zina limagwiritsa ntchito mankhwala osokoneza bongo:

Kuchokera ku ziwalo zam'mimba zam'mimba kumakhala kuphwanya kudya, kutsegula m'mimba, kusanza, kukoma kwazitsulo mkamwa.

Ngati pakachitika zovuta zina, akuwonetsa kukana chithandizo ndi Gliformin, kukaonana ndi dokotala.

Mankhwala Glyformin (malangizo ake amapezeka momasuka pa intaneti) angagwiritsidwe ntchito moyenera kulephera kwa impso, koma pokhapokha pakuwoneka kuti pakuwonjezereka kwa lactic acidosis. Pankhaniyi, ntchito ya impso imayang'aniridwa nthawi zonse (kamodzi pa miyezi 3-6), pomwe mawonekedwe a creatinine amatsika mpaka kufika pa 45 ml / min, chithandizo chimayimitsidwa nthawi yomweyo.

Ngati ntchito ya impso yafupika mwa odwala matenda ashuga apamwamba, mulingo wa metformin uyenera kusintha.

Contraindication, kuyanjana kwa mankhwala

Gliformin sayenera kutumikiridwa chifukwa cha ketoacidosis, matenda osatha a chiwindi, chikomokere, mtima, kuperewera kwa m'mapapo, panthawi yapakati, yoyamwitsa, myocardial infarction, kumva kwambiri magawo a mankhwalawa.

Tengani mosamalitsa mankhwala othandizira matenda a etiology, musanachite opareshoni yayikulu.

Mphamvu ya mankhwala ingathe kuchepa limodzi ndi chithandizo:

• glucocorticosteroid mankhwala
• mahomoni a chithokomiro
• okodzetsa
• nicotinic acid
• mukamamwa mankhwala oletsa kubereka.

Ngati metformin imagwiritsidwa ntchito limodzi ndi insulin, zotumphukira za sulfonylurea, mankhwala osapweteka a antiidal, komanso beta-blockers, pali mwayi wowonjezeranso zotsatira zake.

Kutalika kwa Glformin

Nthawi zina, wodwala wodwala matenda a shuga amawonetsedwa kwa nthawi yayitali - Glformin. Amatengedwa pakamwa ndi madzi okwanira. Chidachi chitha kuthandizira paokha kapena kukhala gawo la mankhwala ophatikiza.

Ngati munthu wodwala matenda ashuga sanalandire metformin, amalimbikitsidwa pa 750 mg kamodzi patsiku. Pambuyo pa masabata awiri, dokotala amasintha mlingo (imwani mapiritsi 2 a 750 mg), kutengera zotsatira za kuyesedwa kwa shuga. Ndi kuchuluka pang'onopang'ono mu kuchuluka kwa mankhwalawa, kumachepa zovuta zomwe zimapangitsa kuchokera kugaya chakudya, makamaka, matenda osokoneza bongo amatha.

Ngati mlingo woyenera saloledwa kukwaniritsa kuchuluka kwa chiwopsezo cha glycemia, ndikofunikira kutenga mlingo waukulu wa mankhwalawa - mapiritsi atatu a 750 mg Prolong kamodzi patsiku.

Anthu omwe amadwala matenda ashuga omwe amatenga metformin ngati mankhwala amamasulidwa nthawi zonse:

1. kumwa Zakudya zofanana
2. ngati atha kupitirira 2000 mg, kusintha kwa mankhwalawa sikumasankhidwa.

Kuti tikwaniritse kuyang'anira kwambiri glycemic, metformin ndi insulin ya mahomoni imagwiritsidwa ntchito ngati mankhwala osakaniza. Choyamba, imwani mankhwalawa muyezo wa mankhwalawa (piritsi limodzi 750 mg) pakudya, ndipo kuchuluka kwa insulin kuyenera kusankhidwa payekha, kutengera shuga la magazi.

Kuchuluka kwa tsiku, ndizovomerezeka kumwa osaposa 2250 mg ya mankhwala, kuwunika kwa madokotala kumawonetsa kuti, ngati mkhalidwe wa thupi umayendetsedwa moyenera, ndikotheka kusintha kwa kumwa mankhwalawa ndikutulutsidwa kwa metformin muyezo wa 3000 mg.

Zimachitika kuti wodwalayo adaphonya kumwa mankhwalawo, pomwe amamuwonetsa kumwa piritsi lotsatira nthawi yokhazikika. Simungatenge mlingo wawiri wa metformin, izi zimapangitsa kukula kwa zosasangalatsa zammbali, kukulitsa zizindikiro za matenda ashuga, zomwe siziyenera kuloledwa.

Kukula kwa Glyformin kuyenera kutengedwa tsiku lililonse, kupewa yopuma.

Wodwalayo ayenera kudziwitsa adokotala za kutha kwa chithandizo, kudziwa malingaliro ake.

Analogs, ndemanga za madokotala

Chifukwa cha kupezeka kwa ma contraindication, mankhwalawa sioyenera odwala ambiri, panthawiyi ndikofunikira kusankha ma analogues a mankhwalawa, amakhalanso ndi zinthu zingapo zogwira ntchito (250, 500, 850, 1000). Glformin akhoza kukhala pamtundu wina ndi mankhwala:

Anthu odwala matenda ashuga omwe amamwa kale mankhwala a Glformin akuwonetsa kuti ali ndi vuto lochulukirapo. Nthawi zambiri, izi zimachitika chifukwa chogwiritsa ntchito molakwika mankhwalawa.

Mankhwala osokoneza bongo amatha kuyambitsa matenda a lactic acidosis. Mawonetsedwe ake akuluakulu: kupweteka kwa minofu, kusanza, nseru, kusokonezeka kwa chikumbumtima. Zizindikiro zotere zikawoneka, ndikofunikira kuti musamwe mankhwalawo.

Madotolo akuti mankhwala a Glformin amatha kuthana ndi matenda a shuga moyenera, malinga ngati mankhwalawo amawonetsedwa mosamalitsa. Kuphatikizanso kwina kwa mankhwalawo ndi mtengo wovomerezeka komanso kupezeka kwa mafakisi.

Endocrinologists amachenjeza kuti munthawi yonse ya mankhwala, mayeso mwadongosolo a serum creatinine amafunikira. Glyformin wa mankhwala osokoneza bongo sayenera kumwedwa:

1. ndi zakumwa zoledzeretsa,
2. mankhwala omwe amakhala ndi ethanol.

Tsoka ilo, matenda ashuga asanduka matenda wamba, komanso pakati pa achinyamata. Mankhwala, ndikofunikira kupereka mankhwala omwe amathandizira kuchepetsa matenda a glycemia, umodzi mwa mankhwalawa anali Glformin. Ngati malangizo ogwiritsira ntchito akatsatidwa ndendende, momwe mankhwalawo amathandizira pakapita kanthawi kochepa.

Zambiri zokhudzana ndi kuchepetsa shuga zimaperekedwa mu kanema munkhaniyi.

Migwirizano ndi magwiritsidwe akusungidwa

Gliformin ndi mankhwala omwe amalembedwa.

Iyenera kusungidwa pamalo owuma, osagwiritsidwa ntchito ndi kulowa kwa dzuwa, pamtunda wa 25 ºС. Ndi kusungidwa koyenera, moyo wa alumali wa mapiritsi a 500 mg ndi zaka 3, mapiritsi a 850 mg ndi 1 gramu - zaka 2.

Kodi mwapeza cholakwika m'mawuwo? Sankhani ndikusindikiza Ctrl + Lowani.